Condition Lookup
Speciality:
Infectious Diseases
Number of Conditions: 417
Diverticulitis
Specialty: Infectious Diseases
Category: Gastrointestinal Tract and Intra-abdominal Infections
Symptoms:
lower left abdominal pain; fever; nausea; constipation or diarrhea; bloating
Root Cause:
Inflammation or infection of diverticula (small pouches in the colon wall) often caused by fecal impaction or micro-perforations.
How it's Diagnosed: videos
CT scan of the abdomen, blood tests (elevated white blood cell count, markers of inflammation like CRP), and, in some cases, colonoscopy (not during acute phase).
Treatment:
Antibiotics for mild to moderate cases, clear liquid diet during acute episodes, and surgery for complications like abscess, perforation, or obstruction.
Medications:
Ciprofloxacin (fluoroquinolone antibiotic) and Metronidazole (nitroimidazole antibiotic) often used together; Amoxicillin-clavulanate as an alternative.
Prevalence:
How common the health condition is within a specific population.
Common, especially in older adults; affects about 35–45% of people over age 60 in Western countries.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Aging, low-fiber diet, obesity, sedentary lifestyle, smoking, and NSAID use.
Prognosis:
The expected outcome or course of the condition over time.
Good with prompt treatment; recurrent episodes may lead to chronic complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Abscess formation, perforation, peritonitis, fistulas, and bowel obstruction.
Lyme Disease
Specialty: Infectious Diseases
Category: Bacterial Infections
Sub-category: Tick-borne Infections
Symptoms:
erythema migrans (bull's-eye rash); fever; chills; fatigue; joint pain; neurological symptoms such as bell's palsy
Root Cause:
Caused by Borrelia burgdorferi, transmitted through the bite of infected Ixodes ticks, leading to systemic infection if untreated.
How it's Diagnosed: videos
Clinical presentation, history of tick exposure, enzyme immunoassay (EIA) or immunoblot (Western blot) testing for antibodies.
Treatment:
Antibiotics for early stages; intravenous antibiotics for severe or late-stage disease.
Medications:
Doxycycline (tetracycline-class antibiotic), amoxicillin (penicillin-class antibiotic), or cefuroxime (cephalosporin-class antibiotic) for early stages. Intravenous ceftriaxone or penicillin G for neurologic or severe cases.
Prevalence:
How common the health condition is within a specific population.
Common in temperate regions, especially the northeastern United States and parts of Europe; incidence varies widely by region.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Outdoor activities in tick-endemic areas, not using protective clothing, and delayed removal of ticks.
Prognosis:
The expected outcome or course of the condition over time.
Good with early diagnosis and treatment; late or untreated cases may lead to chronic symptoms (e.g., Lyme arthritis, neurological issues).
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic joint inflammation, neurological damage, heart rhythm disturbances, post-treatment Lyme disease syndrome (PTLDS).
Scabies
Specialty: Infectious Diseases
Category: Parasitic Skin Infections
Symptoms:
intense itching, especially at night; thin burrow tracks in the skin; rash with small, red bumps
Root Cause:
Infestation by Sarcoptes scabiei mites causing skin irritation.
How it's Diagnosed: videos
Clinical observation of burrows; microscopic examination of skin scrapings for mites or eggs.
Treatment:
Topical scabicides and antihistamines for itching.
Medications:
Permethrin (topical scabicide), ivermectin (oral antiparasitic), antihistamines (e.g., diphenhydramine ) for symptom relief.
Prevalence:
How common the health condition is within a specific population.
Affects over 200 million people worldwide; common in crowded living conditions.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Close contact with infected individuals, crowded environments.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with appropriate treatment; symptoms resolve within weeks.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Secondary bacterial infections (e.g., impetigo), crusted scabies in immunocompromised individuals.
Toxic Epidermal Necrolysis (TEN)
Specialty: Infectious Diseases
Category: Skin and Soft-Tissue Infections
Symptoms:
widespread skin peeling; painful skin lesions; blisters on mucous membranes; fever; skin tenderness; systemic illness symptoms
Root Cause:
Severe immune reaction, often triggered by medications (e.g., antibiotics, anticonvulsants, NSAIDs), leading to widespread epidermal necrosis.
How it's Diagnosed: videos
Clinical observation, skin biopsy showing full-thickness epidermal necrosis.
Treatment:
Discontinuation of the triggering medication, supportive care in an intensive care or burn unit, and possible use of immunosuppressive therapies.
Medications:
IV immunoglobulin (immunomodulator) or cyclosporine (calcineurin inhibitor); corticosteroids are sometimes used, though controversial.
Prevalence:
How common the health condition is within a specific population.
Rare; incidence is 1–2 cases per million annually.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Use of high-risk medications, genetic predispositions (e.g., HLA-B*1502 allele in certain populations).
Prognosis:
The expected outcome or course of the condition over time.
Guarded; mortality rate is approximately 25–50%, depending on severity and comorbidities.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Secondary infections, sepsis, multi-organ failure, scarring, and chronic eye complications.
Cellulitis
Specialty: Infectious Diseases
Category: Skin and Soft-Tissue Infections
Symptoms:
red, swollen, and tender skin; fever; warmth in the affected area; pain and lymphadenopathy
Root Cause:
Bacterial infection of the dermis and subcutaneous tissue, commonly caused by Streptococcus pyogenes or Staphylococcus aureus.
How it's Diagnosed: videos
Clinical evaluation, blood cultures (if systemic symptoms present), and imaging for deeper infections.
Treatment:
Antibiotics, elevation of the affected limb, and wound care.
Medications:
Cephalexin (cephalosporin), clindamycin (lincosamide), or vancomycin (glycopeptide for MRSA).
Prevalence:
How common the health condition is within a specific population.
Common; affects people of all ages, particularly those with compromised immune systems or diabetes.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Breaks in the skin, diabetes, obesity, lymphedema, and poor circulation.
Prognosis:
The expected outcome or course of the condition over time.
Good with early treatment; untreated cellulitis can lead to serious complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Abscess formation, sepsis, necrotizing fasciitis, or chronic swelling.
Erysipelas
Specialty: Infectious Diseases
Category: Skin and Soft-Tissue Infections
Symptoms:
bright red, swollen, warm, and painful skin lesion; fever; chills; swollen lymph nodes; sharp raised edges on the affected area
Root Cause:
Bacterial infection, commonly Group A Streptococcus, affecting the upper dermis and superficial lymphatics.
How it's Diagnosed: videos
Clinical examination; culture of exudate or blood cultures in severe cases; imaging if deeper infection is suspected.
Treatment:
Oral or intravenous antibiotics, supportive measures like elevation and analgesics.
Medications:
Penicillin (beta-lactam antibiotic) is first-line; clindamycin (lincosamide) or erythromycin (macrolide) for penicillin-allergic patients.
Prevalence:
How common the health condition is within a specific population.
Common; particularly among middle-aged and elderly individuals.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Skin injuries, obesity, diabetes, immunosuppression, lymphedema.
Prognosis:
The expected outcome or course of the condition over time.
Generally excellent with appropriate antibiotic therapy.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Recurrence, abscess formation, lymphedema, systemic infection.
Tinea Capitis
Specialty: Infectious Diseases
Category: Skin and Soft-Tissue Infections
Symptoms:
scaly, itchy patches on the scalp; hair breakage leading to bald patches; black dots (broken hairs at scalp level); inflammation or kerion formation
Root Cause:
Fungal infection of the scalp and hair shafts caused by dermatophytes (e.g., Trichophyton and Microsporum species).
How it's Diagnosed: videos
Clinical evaluation, KOH microscopy, fungal culture, or Wood's lamp examination.
Treatment:
Systemic antifungal therapy is essential; topical treatments are supportive.
Medications:
Griseofulvin (fungistatic agent) or terbinafine (allylamine antifungal) are common oral medications.
Prevalence:
How common the health condition is within a specific population.
Common in children; prevalence varies by region.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Overcrowding, poor hygiene, and close contact with infected individuals or animals.
Prognosis:
The expected outcome or course of the condition over time.
Good with treatment; untreated cases may result in permanent hair loss.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Scarring alopecia, secondary bacterial infection, and inflammatory kerion.
Fever of Unknown Origin (FUO)
Specialty: Infectious Diseases
Category: Infectious Diseases
Sub-category: Systemic Conditions
Symptoms:
persistent fever lasting more than three weeks; weakness; night sweats; weight loss; anorexia
Root Cause:
FUO can result from various causes, including infections, malignancies, autoimmune diseases, and other systemic disorders.
How it's Diagnosed: videos
Comprehensive history, physical examination, laboratory tests (CBC, blood cultures, ESR/CRP), imaging (CT, MRI, PET), and biopsy if indicated.
Treatment:
Treatment depends on the identified cause; empirical therapy may be used in select cases while diagnostic efforts are ongoing.
Medications:
Antibiotics (broad-spectrum, such as vancomycin or ceftriaxone ), corticosteroids, or immunosuppressants depending on the cause. These belong to anti-infectives, anti-inflammatory agents, or immunomodulators.
Prevalence:
How common the health condition is within a specific population.
FUO accounts for about 2-3% of hospital admissions in tertiary care settings.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Advanced age, immunosuppression, travel history, or recent surgeries.
Prognosis:
The expected outcome or course of the condition over time.
Prognosis varies widely and depends on the underlying cause. Many cases resolve with appropriate treatment.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Persistent fever can lead to dehydration, organ dysfunction, or worsening of the underlying condition.
Meningitis
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
severe headache; stiff neck; fever; nausea and vomiting; sensitivity to light (photophobia); altered mental status; seizures
Root Cause:
Inflammation of the meninges caused by bacterial, viral, fungal, or parasitic infections.
How it's Diagnosed: videos
Diagnosed through lumbar puncture to analyze CSF, along with blood cultures, and imaging (CT or MRI).
Treatment:
Depends on the cause; bacterial meningitis requires immediate intravenous antibiotics and corticosteroids. Viral meningitis is usually self-limiting and treated supportively.
Medications:
For bacterial meningitis - Third-generation cephalosporins (e.g., ceftriaxone ) and vancomycin ; adjunctive corticosteroids like dexamethasone reduce inflammation. For viral meningitis - Antiviral drugs like acyclovir (for herpes simplex virus) and symptomatic medications.
Prevalence:
How common the health condition is within a specific population.
Annual global incidence varies; bacterial meningitis affects approximately 2.8 per 100,000 annually.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Crowded living conditions, immunosuppression, age extremes (infants and elderly), head trauma, and lack of vaccination.
Prognosis:
The expected outcome or course of the condition over time.
Bacterial meningitis has a high mortality if untreated, but early treatment improves outcomes. Viral meningitis typically has a better prognosis.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Hearing loss, cognitive impairment, seizures, and hydrocephalus.
Pelvic Inflammatory Disease (PID)
Specialty: Infectious Diseases
Category: Genitourinary Tract Infections
Sub-category: Reproductive System Infections
Symptoms:
pelvic pain; abnormal vaginal discharge; pain during intercourse; fever; irregular menstrual bleeding
Root Cause:
Ascending bacterial infection of the upper reproductive tract, often caused by sexually transmitted pathogens such as Neisseria gonorrhoeae or Chlamydia trachomatis.
How it's Diagnosed: videos
Clinical examination, pelvic ultrasound, endometrial biopsy, testing for sexually transmitted infections.
Treatment:
Broad-spectrum antibiotics, removal of IUDs if implicated, hospitalization for severe cases.
Medications:
Ceftriaxone (a cephalosporin) combined with doxycycline (a tetracycline ) and metronidazole (an antiprotozoal agent) for comprehensive coverage.
Prevalence:
How common the health condition is within a specific population.
Affects 4% of women annually in developed countries, with higher rates in sexually active women under 25.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Multiple sexual partners, unprotected intercourse, prior STI, douching.
Prognosis:
The expected outcome or course of the condition over time.
Good with early treatment, but delayed therapy can result in chronic pelvic pain, infertility, or ectopic pregnancy.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Tubo-ovarian abscess, chronic pelvic pain, infertility, peritonitis.
Septic Arthritis
Specialty: Infectious Diseases
Category: Bone and Joint Infections
Symptoms:
sudden onset of joint pain; swelling; redness and warmth over the joint; fever; reduced range of motion
Root Cause:
Infection in the synovial fluid and joint tissue, commonly caused by bacteria (e.g., Staphylococcus aureus or Streptococcus species) or, less frequently, fungi or viruses.
How it's Diagnosed: videos
Synovial fluid aspiration and analysis, blood tests (elevated WBC, ESR, CRP), blood cultures, and imaging (ultrasound or MRI).
Treatment:
Immediate antibiotic therapy and joint drainage via needle aspiration, arthroscopy, or open surgery.
Medications:
Intravenous antibiotics such as ceftriaxone or vancomycin , adjusted based on culture sensitivity results. These antibiotics are bactericidal.
Prevalence:
How common the health condition is within a specific population.
Incidence of 2-10 cases per 100,000 people annually, higher in populations with joint replacements or comorbidities.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Age extremes, pre-existing joint disease, recent joint surgery or trauma, immunosuppression, and intravenous drug use.
Prognosis:
The expected outcome or course of the condition over time.
Favorable with prompt intervention; delayed treatment may result in permanent joint damage.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Joint destruction, osteomyelitis, sepsis, and chronic arthritis.
Fungal Sinusitis
Specialty: Infectious Diseases
Category: Fungal Infections
Symptoms:
nasal congestion; facial pain or pressure; nasal discharge (often thick and discolored); loss of smell; headache; fever (in severe cases)
Root Cause:
Fungal growth in the sinuses due to compromised immune function or environmental exposure.
How it's Diagnosed: videos
Nasal endoscopy, imaging studies (CT or MRI), and fungal culture or biopsy.
Treatment:
Surgical debridement of affected tissue, antifungal medications, and management of underlying conditions.
Medications:
Antifungal medications such as amphotericin B (polyene antifungal) or itraconazole (triazole antifungal).
Prevalence:
How common the health condition is within a specific population.
Rare; higher prevalence in immunocompromised individuals or those with uncontrolled diabetes.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Immunosuppression, diabetes, use of corticosteroids, chronic sinusitis, environmental exposure to fungal spores.
Prognosis:
The expected outcome or course of the condition over time.
Good with early diagnosis and treatment, but delays can lead to severe complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Orbital cellulitis, cavernous sinus thrombosis, intracranial abscess, and systemic fungal spread.
Rhinoscleroma
Specialty: Infectious Diseases
Category: Chronic Granulomatous Infections
Symptoms:
nasal obstruction; purulent nasal discharge; hard nasal masses; facial deformity in advanced stages
Root Cause:
Chronic granulomatous infection caused by Klebsiella rhinoscleromatis.
How it's Diagnosed: videos
Nasal biopsy showing Mikulicz cells; bacterial culture.
Treatment:
Long-term antibiotics, surgery for deformities if needed.
Medications:
Ciprofloxacin or doxycycline (broad-spectrum antibiotics); rifampin in refractory cases.
Prevalence:
How common the health condition is within a specific population.
Endemic in parts of Africa, Central America, and Southeast Asia; rare elsewhere.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Poor socioeconomic conditions, close contact with infected individuals.
Prognosis:
The expected outcome or course of the condition over time.
Good with early treatment; untreated cases may lead to airway obstruction and disfigurement.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Nasal deformity, airway obstruction, and secondary bacterial infections.
Rhinosporidiosis
Specialty: Infectious Diseases
Category: HEENT Infections
Symptoms:
nasal obstruction; chronic nasal discharge; polyp-like growths in the nasal cavity; bleeding from the nose
Root Cause:
Chronic infection caused by Rhinosporidium seeberi, resulting in polypoid growths in the nasal and conjunctival mucosa.
How it's Diagnosed: videos
Histological examination of excised tissue.
Treatment:
Surgical excision of lesions; no effective medical treatment.
Medications:
No specific medications; surgical management is the primary treatment.
Prevalence:
How common the health condition is within a specific population.
Endemic in certain regions of South Asia and Africa.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Exposure to contaminated water or soil.
Prognosis:
The expected outcome or course of the condition over time.
Good with surgical excision; recurrence is possible.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Recurrent lesions, secondary bacterial infections.
Community-Acquired Pneumonia (CAP)
Specialty: Infectious Diseases
Category: Lower Respiratory Tract Infections
Symptoms:
fever; productive cough with purulent sputum; pleuritic chest pain; shortness of breath; fatigue; chills; hypoxia
Root Cause:
Infection of the lung parenchyma caused by bacteria, viruses, or fungi acquired outside of hospital settings.
How it's Diagnosed: videos
Chest X-ray showing infiltrates, clinical symptoms, sputum culture, blood culture, and PCR for pathogens.
Treatment:
Empiric antibiotic therapy, oxygen support, fluids, and antipyretics. Adjust antibiotics based on culture results if needed.
Medications:
Beta-lactams (e.g., amoxicillin-clavulanate), macrolides (e.g., azithromycin ), or fluoroquinolones (e.g., levofloxacin ) depending on severity and patient factors.
Prevalence:
How common the health condition is within a specific population.
Affects about 5–11 cases per 1,000 adults annually; higher in the elderly and those with chronic conditions.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Smoking, chronic obstructive pulmonary disease (COPD), heart disease, diabetes, or recent viral respiratory infection.
Prognosis:
The expected outcome or course of the condition over time.
Good with prompt treatment, though mortality risk increases in older adults or those with comorbidities.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Respiratory failure, sepsis, pleural effusion, empyema, or lung abscess.
Ventilator-Associated Pneumonia (VAP)
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
fever; increased respiratory secretions; difficulty breathing; low oxygen saturation; altered mental status
Root Cause:
Pneumonia caused by bacterial colonization of the airway in mechanically ventilated patients, often involving multidrug-resistant organisms.
How it's Diagnosed: videos
Clinical signs, chest imaging (e.g., infiltrates on chest X-ray), and microbiological analysis of respiratory secretions.
Treatment:
Broad-spectrum antibiotics tailored to identified pathogens, optimization of ventilator settings, and infection control measures.
Medications:
Empiric antibiotics (e.g., piperacillin-tazobactam, vancomycin ); specific antibiotics based on culture results (e.g., meropenem for resistant Gram-negative organisms).
Prevalence:
How common the health condition is within a specific population.
Common in ICUs, affecting 10–20% of mechanically ventilated patients.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Prolonged mechanical ventilation, immunosuppression, prior antibiotic use, and poor oral hygiene.
Prognosis:
The expected outcome or course of the condition over time.
Variable; early treatment improves outcomes, but VAP can lead to prolonged hospitalization or death in severe cases.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Sepsis, acute respiratory distress syndrome (ARDS), multi-organ failure, and prolonged hospital stay.
Histoplasmosis
Specialty: Infectious Diseases
Category: Fungal Infections
Symptoms:
fever; cough; chest pain; fatigue; shortness of breath; night sweats; weight loss
Root Cause:
Infection by the fungus Histoplasma capsulatum, commonly through inhalation of spores from contaminated soil or bird/bat droppings.
How it's Diagnosed: videos
Antigen detection in blood or urine, fungal cultures, histopathology, and imaging studies like chest X-rays or CT scans.
Treatment:
Antifungal medications such as itraconazole (first-line for mild cases) or amphotericin B (for severe cases).
Medications:
Itraconazole (triazole antifungal) and amphotericin B (polyene antifungal) for more severe infections.
Prevalence:
How common the health condition is within a specific population.
Endemic in certain areas like the Ohio and Mississippi River valleys in the United States; affects 500,000 people annually in the U.S.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Living in or traveling to endemic areas, immunosuppression, occupational exposure to bird/bat droppings.
Prognosis:
The expected outcome or course of the condition over time.
Favorable in mild cases; chronic or disseminated histoplasmosis can be life-threatening without treatment.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic pulmonary histoplasmosis, disseminated histoplasmosis, pericarditis, or adrenal insufficiency in severe cases.
Blastomycosis
Specialty: Infectious Diseases
Category: Fungal Infections
Symptoms:
fever; cough; chest pain; fatigue; night sweats; skin lesions; muscle and joint pain
Root Cause:
Infection caused by the Blastomyces fungus, typically found in moist soil and decomposing organic matter; affects the lungs and can disseminate to other body parts.
How it's Diagnosed: videos
Fungal culture, microscopy of sputum or tissue, urine antigen tests, chest X-rays, and biopsy.
Treatment:
Long-term antifungal therapy; severe cases may require intravenous medications.
Medications:
Itraconazole (antifungal triazole) for mild-to-moderate cases; Amphotericin B (antifungal polyene) for severe or disseminated disease.
Prevalence:
How common the health condition is within a specific population.
Most common in areas near the Great Lakes, Mississippi, and Ohio River valleys; primarily affects people exposed to soil and vegetation.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Occupational or recreational exposure to soil and decomposing wood, immunosuppression.
Prognosis:
The expected outcome or course of the condition over time.
Good if treated early; untreated disseminated blastomycosis can be fatal.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic pulmonary disease, dissemination to the skin, bones, and central nervous system.
Aspergillosis
Specialty: Infectious Diseases
Category: Fungal Infections
Symptoms:
fever; cough; shortness of breath; chest pain; fatigue; weight loss; sinus congestion; wheezing
Root Cause:
Infection caused by the Aspergillus fungus, which is found in soil, decaying organic matter, and indoor environments; affects individuals with weakened immune systems or underlying lung conditions.
How it's Diagnosed: videos
Blood tests, imaging studies (CT or X-rays of lungs), sputum cultures, biopsy, galactomannan assay, and PCR for Aspergillus DNA.
Treatment:
Antifungal medications, surgical removal of fungal masses (if necessary), corticosteroids in allergic forms.
Medications:
Voriconazole (antifungal triazole), Amphotericin B (antifungal polyene), Itraconazole (antifungal triazole), and Posaconazole (antifungal triazole).
Prevalence:
How common the health condition is within a specific population.
Rare in the general population; more common in individuals with compromised immune systems or chronic lung diseases.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Immunosuppression, long-term corticosteroid use, chemotherapy, solid organ transplants, hematologic malignancies, and existing lung diseases such as COPD or tuberculosis.
Prognosis:
The expected outcome or course of the condition over time.
Variable; invasive aspergillosis has a high mortality rate without prompt treatment, while allergic forms are manageable with proper therapy.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Respiratory failure, dissemination to other organs, allergic bronchopulmonary aspergillosis (ABPA), chronic pulmonary aspergillosis.
Influenza
Specialty: Infectious Diseases
Category: COVID-19 Reinfections
Symptoms:
fever; chills; headache; muscle aches; fatigue; sore throat; cough; runny nose
Root Cause:
Influenza is a viral infection that primarily affects the respiratory system. The virus causes inflammation of the airways, leading to systemic symptoms.
How it's Diagnosed: videos
Diagnosis is typically clinical, but can be confirmed with rapid antigen tests or PCR.
Treatment:
Antiviral medications such as oseltamivir or zanamivir can reduce symptom duration if taken early. Supportive care includes hydration, rest, and fever management.
Medications:
Oseltamivir (Tamiflu ) and zanamivir (Relenza ) are neuraminidase inhibitors used to treat influenza . These medications shorten the duration of illness if started within 48 hours of symptom onset.
Prevalence:
How common the health condition is within a specific population.
Influenza affects millions worldwide each year, with seasonal outbreaks occurring mostly during fall and winter.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Young children, elderly adults, pregnant women, and individuals with chronic health conditions (e.g., asthma, diabetes) are at higher risk.
Prognosis:
The expected outcome or course of the condition over time.
Most individuals recover within 1-2 weeks, but complications can occur, especially in high-risk populations.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Can lead to pneumonia, bronchitis, sinus infections, and worsening of underlying chronic diseases.
Severe Acute Respiratory Syndrome (SARS)
Specialty: Infectious Diseases
Category: Lower Respiratory Tract Infections
Symptoms:
high fever; dry cough; shortness of breath; muscle pain; headache; chills; diarrhea; fatigue
Root Cause:
Viral infection caused by the SARS-CoV coronavirus, primarily transmitted through respiratory droplets or close contact. Severe cases involve acute respiratory distress syndrome (ARDS).
How it's Diagnosed: videos
Diagnosis involves PCR testing for SARS-CoV, chest imaging showing pneumonia or ARDS, and serologic tests for antibodies.
Treatment:
Supportive care, including oxygen therapy, mechanical ventilation in severe cases, and management of secondary infections. No specific antiviral treatment is universally accepted.
Medications:
Experimental - Ribavirin , corticosteroids, and interferons were used during the 2003 outbreak but with limited efficacy. Supportive medications - Antipyretics for fever, analgesics for pain, and bronchodilators for respiratory relief.
Prevalence:
How common the health condition is within a specific population.
Emerged in 2002–2003 with approximately 8,000 cases globally and a mortality rate of about 9.6%.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Close contact with infected individuals, healthcare workers exposed to infected patients, and travelers to outbreak areas.
Prognosis:
The expected outcome or course of the condition over time.
Early supportive care improves outcomes. Severe cases may lead to high mortality, especially in older adults or those with comorbidities.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
ARDS, septic shock, organ failure, and long-term pulmonary dysfunction in survivors.
Lung Abscess
Specialty: Infectious Diseases
Category: Lower Respiratory Tract Infections
Symptoms:
persistent cough with foul-smelling sputum; fever; chills; night sweats; chest pain; fatigue; weight loss; shortness of breath
Root Cause:
Localized collection of pus in the lung tissue due to necrosis caused by bacterial infection, often following aspiration or obstruction of airways.
How it's Diagnosed: videos
Diagnosis involves imaging studies (chest X-ray, CT scan) to identify cavities with air-fluid levels, sputum culture, bronchoscopy, and blood tests to detect infection markers.
Treatment:
Treatment typically involves prolonged antibiotic therapy, drainage of the abscess if needed, and supportive care such as oxygen therapy.
Medications:
Antibiotics - Beta-lactam antibiotics combined with beta-lactamase inhibitors (e.g., amoxicillin-clavulanate), clindamycin , or carbapenems. These are used for anaerobic and polymicrobial infections. Adjunct medications - Analgesics for pain management and antipyretics for fever.
Prevalence:
How common the health condition is within a specific population.
Relatively rare; accounts for less than 1% of cases of pneumonia in developed countries, more common in individuals with risk factors like aspiration or immunosuppression.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Aspiration due to impaired swallowing or altered consciousness (e.g., alcohol use, anesthesia), poor dental hygiene, chronic lung diseases, or immunosuppression.
Prognosis:
The expected outcome or course of the condition over time.
Most patients recover with appropriate antibiotic therapy; however, untreated cases can lead to severe complications. Mortality is higher in immunocompromised patients.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Empyema, bronchopleural fistula, sepsis, hemorrhage, and chronic lung disease.
Giardiasis
Specialty: Infectious Diseases
Category: Gastrointestinal Tract and Intra-abdominal Infections
Symptoms:
watery diarrhea; greasy, foul-smelling stools; abdominal cramps; bloating; nausea; fatigue; weight loss
Root Cause:
Protozoan parasite Giardia lamblia infects the small intestine, often transmitted via contaminated water, food, or contact with infected individuals.
How it's Diagnosed: videos
Stool tests for Giardia antigens, microscopic examination of stool samples, or molecular tests like PCR.
Treatment:
Antiparasitic medications, hydration, and supportive care.
Medications:
Metronidazole (nitroimidazole antibiotic), Tinidazole (similar to metronidazole , also a nitroimidazole), or Nitazoxanide (antiprotozoal agent).
Prevalence:
How common the health condition is within a specific population.
Common in developing countries; in the U.S., Giardia is a leading cause of waterborne outbreaks of diarrhea.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Consuming contaminated water (e.g., from lakes or streams), poor sanitation, travel to endemic areas, and close contact with infected individuals.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with treatment; without treatment, symptoms can persist or become chronic.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic diarrhea, malabsorption, weight loss, and in severe cases, growth retardation in children.
Alcoholic Hepatitis
Specialty: Infectious Diseases
Category: Gastrointestinal Tract and Intra-abdominal Infections
Symptoms:
jaundice; abdominal pain; nausea; vomiting; fever; weight loss; fatigue; anorexia
Root Cause:
Inflammation and liver cell damage caused by prolonged and excessive alcohol consumption leading to toxic metabolites.
How it's Diagnosed: videos
Clinical history of alcohol use, physical examination, liver function tests (elevated AST, ALT, and bilirubin levels), imaging (ultrasound/CT), and sometimes liver biopsy.
Treatment:
Cessation of alcohol, nutritional support, corticosteroids (for severe cases), and addressing complications like infections or ascites.
Medications:
Medications include corticosteroids (e.g., prednisolone ), which reduce inflammation; pentoxifylline , a phosphodiesterase inhibitor that may prevent complications like hepatorenal syndrome. Vitamin supplementation (e.g., thiamine and folate) is often provided for nutritional deficiencies.
Prevalence:
How common the health condition is within a specific population.
Alcoholic hepatitis is most common in individuals with a history of chronic alcohol use, with a prevalence of approximately 1–2% of heavy drinkers annually.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Chronic heavy alcohol consumption, malnutrition, genetic predisposition, female gender (higher susceptibility), obesity, and prior liver disease.
Prognosis:
The expected outcome or course of the condition over time.
Varies with severity; mild cases may recover with alcohol cessation, while severe cases have a high mortality rate without intervention.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Liver cirrhosis, portal hypertension, ascites, hepatic encephalopathy, and increased risk of infections.
Acute Disseminated Encephalomyelitis (ADEM)
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
fever; headache; nausea; vomiting; confusion; seizures; motor weakness; vision problems; lethargy
Root Cause:
An autoimmune response often triggered by an infection or, less commonly, vaccination, causing inflammation and demyelination in the brain and spinal cord.
How it's Diagnosed: videos
Clinical evaluation, MRI of the brain (showing diffuse demyelination), lumbar puncture (to analyze cerebrospinal fluid), and exclusion of other conditions like multiple sclerosis.
Treatment:
High-dose corticosteroids (e.g., methylprednisolone), plasma exchange (plasmapheresis), intravenous immunoglobulin (IVIG), and supportive care.
Medications:
Corticosteroids (e.g., methylprednisolone for reducing inflammation), IVIG (immunomodulatory therapy), or plasmapheresis (used when steroids are insufficient). Corticosteroids are classified as anti-inflammatory agents.
Prevalence:
How common the health condition is within a specific population.
Rare; estimated annual incidence is 0.4-0.8 per 100,000 people, more common in children than adults.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Recent viral or bacterial infections, recent vaccination, genetic predisposition, or underlying autoimmune disorders.
Prognosis:
The expected outcome or course of the condition over time.
Good in most cases; symptoms often resolve with treatment, although some individuals may experience residual neurological deficits.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Long-term neurological impairment, recurrence (though rare), or progression to conditions like multiple sclerosis in some cases.
Brain Abscess
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
headache; fever; nausea; vomiting; neurological deficits; seizures; altered mental status
Root Cause:
Focal collection of pus in the brain tissue, often caused by bacterial or fungal infections entering through the bloodstream, contiguous spread, or trauma.
How it's Diagnosed: videos
MRI or CT scan with contrast, blood cultures, and biopsy of the abscess for microbiological testing.
Treatment:
Surgical drainage or aspiration, combined with broad-spectrum antibiotics tailored based on culture results.
Medications:
Antibiotics such as ceftriaxone (a cephalosporin) or metronidazole (an anti-anaerobic agent). For fungal infections, amphotericin B or fluconazole may be used.
Prevalence:
How common the health condition is within a specific population.
Rare, with an estimated incidence of 0.3 to 1.3 cases per 100,000 people annually.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Immunocompromised status (HIV, organ transplantation), chronic sinusitis, otitis media, congenital heart defects, head trauma.
Prognosis:
The expected outcome or course of the condition over time.
With prompt treatment, mortality rates are around 10–20%, but neurological deficits may persist.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Increased intracranial pressure, brain herniation, seizures, recurrence of infection, or neurological impairments.
Neurocysticercosis
Specialty: Infectious Diseases
Category: CNS Infections
Sub-category: Parasitic Infections
Symptoms:
seizures; headache; nausea; vomiting; vision problems; hydrocephalus; altered mental status
Root Cause:
Infection of the central nervous system by Taenia solium larvae (pork tapeworm), leading to cyst formation in the brain.
How it's Diagnosed: videos
Neuroimaging (MRI or CT) revealing cysts or calcifications, serologic tests for T. solium antibodies, and CSF analysis.
Treatment:
Antiparasitic therapy with albendazole or praziquantel, corticosteroids to reduce inflammation, anticonvulsants for seizure management, and surgical intervention in severe cases.
Medications:
Albendazole (antiparasitic), praziquantel (antiparasitic), dexamethasone (corticosteroid), and levetiracetam or phenytoin (anticonvulsants).
Prevalence:
How common the health condition is within a specific population.
Leading cause of acquired epilepsy in developing countries; affects millions globally, particularly in regions with poor sanitation.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Consumption of undercooked pork, poor sanitation, close contact with infected individuals, and living in endemic areas.
Prognosis:
The expected outcome or course of the condition over time.
Favorable with treatment in uncomplicated cases; long-term anticonvulsant therapy may be required for seizure control.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic epilepsy, hydrocephalus, intracranial hypertension, and neurological deficits.
HIV-Associated Nephropathy (HIVAN)
Specialty: Infectious Diseases
Category: HIV and Kidney Health
Symptoms:
swelling in legs and feet; frothy urine; reduced urine output; high blood pressure
Root Cause:
Direct infection of renal epithelial cells by HIV, leading to collapsing focal segmental glomerulosclerosis (FSGS).
How it's Diagnosed: videos
Urinalysis, renal function tests, renal biopsy, and imaging studies.
Treatment:
ART, angiotensin-converting enzyme (ACE) inhibitors, and corticosteroids in some cases. Dialysis or kidney transplantation in advanced disease.
Medications:
Antiretrovirals, ACE inhibitors, or angiotensin II receptor blockers (ARBs) for blood pressure and renal protection.
Prevalence:
How common the health condition is within a specific population.
Affects up to 10% of HIV-infected individuals, with a higher prevalence in Black populations.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Black ethnicity, advanced HIV, genetic predisposition (e.g., APOL1 gene variants).
Prognosis:
The expected outcome or course of the condition over time.
Early ART initiation improves outcomes; untreated cases may lead to end-stage renal disease (ESRD).
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic kidney disease, ESRD, and cardiovascular complications.
Acinetobacter
Specialty: Infectious Diseases
Category: Bacterial Infections
Symptoms:
fever; chills; skin infections; difficulty breathing (in pneumonia); pain at the infection site; sepsis in severe cases
Root Cause:
Opportunistic bacterial infection caused by the Acinetobacter genus, typically occurring in immunocompromised individuals or hospitalized patients.
How it's Diagnosed: videos
Blood cultures, wound cultures, respiratory cultures, imaging studies (like X-rays or CT scans for pneumonia), and susceptibility testing for antibiotic resistance.
Treatment:
Primarily with antibiotics tailored to the specific strain’s resistance profile; supportive care may be needed for severe infections.
Medications:
Antibiotics such as carbapenems (e.g., meropenem or imipenem ) are often used, but due to multidrug resistance, alternatives like colistin , polymyxins, or sulbactam may be prescribed. These are classified as antimicrobial agents.
Prevalence:
How common the health condition is within a specific population.
Common in healthcare settings; Acinetobacter baumannii is a significant cause of hospital-acquired infections globally.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Prolonged hospital stays, use of ventilators, invasive procedures, immunosuppression, recent surgery, and prior antibiotic use.
Prognosis:
The expected outcome or course of the condition over time.
Varies; early diagnosis and treatment improve outcomes, but multidrug resistance poses significant challenges. Mortality is higher in critically ill patients.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Sepsis, pneumonia, bloodstream infections, wound infections, and treatment failures due to antimicrobial resistance.
Acrodermatitis Chronica Atrophicans
Specialty: Infectious Diseases
Category: Bacterial Infections
Sub-category: Lyme Disease Manifestation
Symptoms:
bluish-red discoloration of the skin; skin thinning; localized swelling; numbness; muscle weakness
Root Cause:
A late-stage skin manifestation of Lyme disease caused by Borrelia burgdorferi infection.
How it's Diagnosed: videos
Clinical history, physical examination, Lyme disease antibody tests (ELISA and Western blot), and skin biopsy in some cases.
Treatment:
Long-term antibiotic therapy, typically oral doxycycline or intravenous ceftriaxone.
Medications:
Doxycycline (a tetracycline antibiotic) or ceftriaxone (a cephalosporin antibiotic). Both are antimicrobial agents.
Prevalence:
How common the health condition is within a specific population.
Rare; occurs in late stages of untreated or inadequately treated Lyme disease, particularly in Europe.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Previous untreated Lyme disease, living in or visiting tick-endemic areas, delayed diagnosis of early Lyme disease.
Prognosis:
The expected outcome or course of the condition over time.
Good if treated early, but prolonged or irreversible skin changes may occur in advanced cases.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic skin changes, peripheral neuropathy, and persistent Lyme disease symptoms in untreated cases.
Actinomycosis
Specialty: Infectious Diseases
Category: Bacterial Infections
Symptoms:
painful swelling or abscess; draining sinuses; foul-smelling discharge; fever; weight loss
Root Cause:
Chronic bacterial infection caused by Actinomyces species, which are facultatively anaerobic, gram-positive bacteria.
How it's Diagnosed: videos
Clinical examination, imaging studies (CT or MRI), and microbiological culture of pus or tissue samples.
Treatment:
Prolonged antibiotic therapy, often with high-dose penicillin, combined with surgical drainage or debridement if necessary.
Medications:
Penicillin (beta-lactam antibiotic), doxycycline (tetracycline antibiotic), or clindamycin (lincosamide antibiotic) for patients allergic to penicillin.
Prevalence:
How common the health condition is within a specific population.
Rare; typically occurs in individuals with poor oral hygiene or following dental procedures.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Dental infections, trauma, surgery, immunosuppression, and intrauterine device (IUD) use.
Prognosis:
The expected outcome or course of the condition over time.
Good with timely and prolonged treatment; untreated cases can result in severe complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Fistula formation, osteomyelitis, chronic abscess, or systemic spread leading to organ involvement.
Anthrax
Specialty: Infectious Diseases
Category: Bacterial Infections
Sub-category: Zoonotic Disease
Symptoms:
cutaneous ulcers with black eschar; fever; malaise; severe respiratory distress in inhalational anthrax; nausea and vomiting in gastrointestinal anthrax
Root Cause:
Infection caused by Bacillus anthracis, a spore-forming bacterium that produces toxins.
How it's Diagnosed: videos
Clinical history, blood cultures, polymerase chain reaction (PCR) testing, and imaging studies for inhalational anthrax.
Treatment:
Early antibiotic therapy is critical, often combined with antitoxins for severe cases.
Medications:
Ciprofloxacin (a fluoroquinolone antibiotic), doxycycline (a tetracycline antibiotic), and raxibacumab (a monoclonal antibody antitoxin).
Prevalence:
How common the health condition is within a specific population.
Rare in developed countries; outbreaks occur sporadically in agricultural regions with infected livestock.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Exposure to infected animals or animal products, occupational exposure, and bioterrorism.
Prognosis:
The expected outcome or course of the condition over time.
Varies; cutaneous anthrax has a high survival rate with treatment, but inhalational anthrax has a high mortality rate if not treated promptly.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Sepsis, meningitis, respiratory failure, and death in severe cases.
Bacterial Conjunctivitis (Pink Eye)
Specialty: Infectious Diseases
Category: Bacterial Infections
Symptoms:
red or pink discoloration of the eye; thick yellow or green discharge; crusty eyelashes; itchiness or irritation; increased tearing; mild swelling of the eyelids
Root Cause:
Infection of the conjunctiva caused by bacteria such as Staphylococcus aureus, Streptococcus pneumoniae, or Haemophilus influenzae.
How it's Diagnosed: videos
Clinical examination; evaluation of symptoms and patient history; swab and culture of conjunctival discharge for definitive identification.
Treatment:
Topical antibiotics, proper eye hygiene, and avoiding irritants or allergens.
Medications:
Antibiotic eye drops or ointments such as erythromycin (macrolide antibiotic) or fluoroquinolones (e.g., ciprofloxacin or ofloxacin ). These are classified as antibacterial agents.
Prevalence:
How common the health condition is within a specific population.
Common; affects millions annually, particularly children and individuals in close-contact settings.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Poor hygiene, exposure to infected individuals, use of contaminated cosmetics, or contact lenses.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with appropriate treatment; symptoms typically resolve within 7–10 days.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Rare, but can include corneal ulcers or spread of infection if untreated.
Bacterial Endophthalmitis
Specialty: Infectious Diseases
Category: Bacterial Infections
Symptoms:
severe eye pain; loss of vision; redness; swelling; sensitivity to light; discharge from the eye
Root Cause:
Intraocular infection caused by bacteria, often following surgery (e.g., cataract surgery), trauma, or systemic infection. Common pathogens include Staphylococcus epidermidis and Pseudomonas aeruginosa.
How it's Diagnosed: videos
Clinical symptoms, vitreous fluid analysis (culture and Gram stain), and imaging tests like ultrasound.
Treatment:
Intravitreal antibiotic injections, vitrectomy, and sometimes systemic antibiotics.
Medications:
Intravitreal antibiotics such as vancomycin (glycopeptide) for Gram-positive bacteria and ceftazidime (third-generation cephalosporin) for Gram-negative bacteria. Systemic antibiotics may include fluoroquinolones.
Prevalence:
How common the health condition is within a specific population.
Rare; approximately 0.04%–0.1% incidence following eye surgery.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Recent ocular surgery, penetrating eye trauma, or systemic infections.
Prognosis:
The expected outcome or course of the condition over time.
Variable; depends on the severity and timing of treatment. Early intervention often preserves vision.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Permanent vision loss or enucleation (removal of the eye) in severe cases.
Bacterial Keratitis
Specialty: Infectious Diseases
Category: Bacterial Infections
Symptoms:
eye pain; redness; blurred vision; sensitivity to light; discharge; corneal opacity or white spot on the cornea
Root Cause:
Bacterial infection of the cornea caused by pathogens such as Pseudomonas aeruginosa or Staphylococcus aureus.
How it's Diagnosed: videos
Slit-lamp examination, corneal scraping for culture, and sensitivity testing.
Treatment:
Topical antibiotics, removal of infected corneal tissue (debridement), and supportive care.
Medications:
Fortified antibiotics such as tobramycin (aminoglycoside) and cefazolin (cephalosporin) applied as eye drops.
Prevalence:
How common the health condition is within a specific population.
Moderate; more common in individuals using contact lenses or following corneal injury.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Contact lens misuse, trauma to the cornea, and compromised immune defenses.
Prognosis:
The expected outcome or course of the condition over time.
Good if treated early; delayed treatment can lead to scarring or vision loss.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Corneal ulcers, perforation, or permanent vision impairment.
Bacterial Sepsis
Specialty: Infectious Diseases
Category: Bacterial Infections
Symptoms:
fever; chills; rapid heart rate; rapid breathing; low blood pressure; confusion; reduced urine output
Root Cause:
Systemic inflammatory response caused by bacterial infection in the blood, often due to Gram-positive (e.g., Staphylococcus aureus) or Gram-negative (e.g., Escherichia coli) bacteria.
How it's Diagnosed: videos
Blood cultures, imaging studies to locate infection, complete blood count, and markers like procalcitonin or C-reactive protein.
Treatment:
Prompt administration of broad-spectrum antibiotics, source control (e.g., draining abscess), and supportive care in intensive care.
Medications:
Broad-spectrum antibiotics such as piperacillin-tazobactam (penicillin/beta-lactamase inhibitor) or carbapenems. Tailored therapy based on culture results.
Prevalence:
How common the health condition is within a specific population.
Significant; affects millions globally, with high mortality in severe cases.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Immunosuppression, invasive procedures, chronic illnesses (e.g., diabetes), or hospital-acquired infections.
Prognosis:
The expected outcome or course of the condition over time.
Varies; early treatment improves outcomes. Severe cases can lead to multi-organ failure and death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Septic shock, multi-organ dysfunction, and long-term disability.
Bacteroides Infection
Specialty: Infectious Diseases
Category: Bacterial Infections
Symptoms:
abdominal pain; fever; abscess formation; diarrhea; foul-smelling discharge; skin infections
Root Cause:
Infection caused by Bacteroides species, obligate anaerobic bacteria commonly found in the gastrointestinal tract.
How it's Diagnosed: videos
Culture and sensitivity testing of infected tissue or fluids; imaging to detect abscesses.
Treatment:
Drainage of abscesses, surgical debridement, and targeted antibiotic therapy.
Medications:
Metronidazole (nitroimidazole), clindamycin (lincosamide), or beta-lactam/beta-lactamase inhibitors like amoxicillin-clavulanate.
Prevalence:
How common the health condition is within a specific population.
Common in intra-abdominal infections, post-surgical infections, and pelvic inflammatory disease.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Abdominal surgery, trauma, or conditions causing gastrointestinal perforation.
Prognosis:
The expected outcome or course of the condition over time.
Good with prompt treatment; untreated infections can be life-threatening.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Abscess formation, systemic spread (bacteremia), and chronic infections.
Bartonellosis (Bartonella Infection)
Specialty: Infectious Diseases
Category: Bacterial Infections
Symptoms:
fever; malaise; swollen lymph nodes; skin lesions; bone pain; neurological symptoms in severe cases
Root Cause:
Infection by Bartonella species, transmitted by vectors such as fleas or sandflies. Notable forms include cat scratch disease (Bartonella henselae) and Carrion's disease (Bartonella bacilliformis).
How it's Diagnosed: videos
Blood cultures, serological testing, and PCR for Bartonella DNA.
Treatment:
Antibiotic therapy and symptomatic management.
Medications:
Azithromycin (macrolide) for mild cases; doxycycline (tetracycline ) combined with rifampin for severe or systemic infections.
Prevalence:
How common the health condition is within a specific population.
Variable; more common in regions with endemic transmission or vector exposure.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Exposure to infected animals (e.g., cats), vector bites, or immunosuppression.
Prognosis:
The expected outcome or course of the condition over time.
Generally favorable with treatment; severe forms require intensive management.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Endocarditis, neurological dysfunction, or vascular lesions in severe cases.
Botulism
Specialty: Infectious Diseases
Category: Bacterial Infections
Symptoms:
muscle weakness; blurred vision; drooping eyelids; slurred speech; difficulty swallowing; difficulty breathing; paralysis
Root Cause:
Caused by the neurotoxin produced by Clostridium botulinum, which blocks acetylcholine release at neuromuscular junctions, leading to paralysis.
How it's Diagnosed: videos
Based on clinical symptoms, patient history (e.g., ingestion of contaminated food or wound exposure), and confirmed with laboratory tests such as toxin assays or stool cultures.
Treatment:
Administering antitoxins, supportive care (e.g., mechanical ventilation if respiratory muscles are affected), and wound debridement in wound botulism cases.
Medications:
Botulinum antitoxin (neutralizes circulating toxins); antibiotics such as penicillin or metronidazole for wound botulism to address infection (penicillin
Prevalence:
How common the health condition is within a specific population.
Rare; approximately 1,000 cases annually worldwide, including foodborne, wound, and infant botulism.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Ingesting improperly preserved or canned foods, intravenous drug use (wound botulism), and consuming honey in infants under 1 year.
Prognosis:
The expected outcome or course of the condition over time.
With prompt treatment, most patients recover fully, though recovery may take weeks to months; untreated cases can be fatal due to respiratory failure.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Respiratory failure, long-term muscle weakness, and secondary infections due to prolonged hospitalization.
Brucellosis
Specialty: Infectious Diseases
Category: Bacterial Infections
Symptoms:
fever; sweats; fatigue; joint pain; muscle pain; weight loss
Root Cause:
Caused by Brucella species bacteria, transmitted from infected animals or contaminated animal products, leading to systemic infection.
How it's Diagnosed: videos
Blood cultures, serologic tests (e.g., Brucella antibody titers), and molecular methods (PCR).
Treatment:
Prolonged antibiotic therapy to eradicate infection and prevent relapses.
Medications:
Doxycycline (tetracycline antibiotic) and rifampin (rifamycin antibiotic) combination therapy for 6 weeks; in severe cases, streptomycin or gentamicin (aminoglycosides) may be added.
Prevalence:
How common the health condition is within a specific population.
Endemic in regions such as the Mediterranean, the Middle East, South America, and sub-Saharan Africa; approximately 500,000 cases annually worldwide.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Occupational exposure (e.g., veterinarians, farmers), consumption of unpasteurized dairy products, and travel to endemic regions.
Prognosis:
The expected outcome or course of the condition over time.
Good with treatment; untreated cases may lead to chronic brucellosis with relapsing symptoms.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Osteomyelitis, endocarditis, and chronic fatigue syndrome.
Burkholderia Cepacia Infection
Specialty: Infectious Diseases
Category: Bacterial Infections
Symptoms:
fever; cough; shortness of breath; chest pain; fatigue; sepsis in severe cases
Root Cause:
Opportunistic pathogen causing infections in immunocompromised individuals or those with chronic conditions like cystic fibrosis.
How it's Diagnosed: videos
Sputum cultures, blood cultures, and molecular testing (e.g., PCR).
Treatment:
Combination antibiotic therapy tailored to susceptibility testing due to resistance.
Medications:
Ceftazidime (third-generation cephalosporin), meropenem (carbapenem), and sulfamethoxazole-trimethoprim (sulfonamide antibiotic).
Prevalence:
How common the health condition is within a specific population.
Rare but significant in hospital settings and among cystic fibrosis patients.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Cystic fibrosis, chronic lung disease, immunosuppression, and prolonged hospital stays.
Prognosis:
The expected outcome or course of the condition over time.
Variable; can be severe in immunocompromised patients or those with underlying conditions.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Respiratory failure, septicemia, and increased mortality in vulnerable populations.
Campylobacter Infections
Specialty: Infectious Diseases
Category: Bacterial Infections
Symptoms:
diarrhea; abdominal pain; fever; nausea; vomiting
Root Cause:
Caused by Campylobacter jejuni or Campylobacter coli, often through contaminated food or water, leading to gastrointestinal inflammation.
How it's Diagnosed: videos
Stool cultures, molecular assays, and antigen tests.
Treatment:
Supportive care for mild cases; antibiotics for severe cases or immunocompromised patients.
Medications:
Azithromycin (macrolide antibiotic) or ciprofloxacin (fluoroquinolone antibiotic).
Prevalence:
How common the health condition is within a specific population.
One of the most common causes of bacterial diarrhea worldwide, with an estimated 96 million cases annually.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Consumption of undercooked poultry, unpasteurized milk, contaminated water, and international travel.
Prognosis:
The expected outcome or course of the condition over time.
Usually self-limiting within a week; antibiotics hasten recovery in severe cases.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Guillain-Barré syndrome, reactive arthritis, and bloodstream infections.
Cardiobacterium Infection
Specialty: Infectious Diseases
Category: Bacterial Infections
Symptoms:
fever; malaise; fatigue; weight loss; night sweats; heart murmur
Root Cause:
Caused by Cardiobacterium hominis, a member of the HACEK group, leading to endocarditis or bloodstream infections.
How it's Diagnosed: videos
Blood cultures, echocardiography, and molecular testing (e.g., PCR).
Treatment:
Prolonged antibiotic therapy tailored to susceptibility testing.
Medications:
Ceftriaxone (third-generation cephalosporin), ampicillin (beta-lactam antibiotic), or gentamicin (aminoglycoside antibiotic).
Prevalence:
How common the health condition is within a specific population.
Rare; typically occurs in patients with predisposing heart conditions or prosthetic valves.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Pre-existing heart valve disease, dental procedures, or poor dental hygiene.
Prognosis:
The expected outcome or course of the condition over time.
Good with treatment, but complications may arise if untreated.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Valve damage, heart failure, and systemic embolism.
CBRNE-Related Botulism
Specialty: Infectious Diseases
Category: Bacterial Infections
Sub-category: Bioterrorism-related diseases
Symptoms:
acute flaccid paralysis; respiratory failure; blurred vision; difficulty speaking or swallowing
Root Cause:
Exposure to Clostridium botulinum toxin as a result of deliberate contamination or bioterrorism.
How it's Diagnosed: videos
Similar to naturally occurring botulism; laboratory confirmation of toxin in serum or environmental samples.
Treatment:
Prompt administration of botulinum antitoxin and intensive supportive care, including respiratory support.
Medications:
Botulinum antitoxin; antibiotics are generally not recommended unless a secondary wound infection is present.
Prevalence:
How common the health condition is within a specific population.
Extremely rare; associated with intentional acts of bioterrorism.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
High-risk exposure scenarios, such as handling contaminated materials.
Prognosis:
The expected outcome or course of the condition over time.
Good with immediate medical intervention; untreated cases may result in death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Long-term muscle weakness, prolonged hospitalization, and psychological trauma.
CBRNE - Staphylococcal Enterotoxin B
Specialty: Infectious Diseases
Category: Bacterial Infections
Symptoms:
fever; chills; headache; nausea; vomiting; diarrhea; shortness of breath; potential septic shock
Root Cause:
Caused by exposure to Staphylococcus aureus enterotoxins, which act as superantigens triggering an exaggerated immune response.
How it's Diagnosed: videos
Clinical evaluation based on symptoms and potential exposure history. Laboratory confirmation by identifying enterotoxins in biological samples.
Treatment:
Supportive care (fluids, oxygen therapy). Antibiotics if secondary bacterial infection is suspected.
Medications:
Beta-lactam antibiotics such as cefazolin for secondary infections. Antipyretics like acetaminophen to reduce fever.
Prevalence:
How common the health condition is within a specific population.
Rare; typically associated with bioterrorism events or foodborne outbreaks.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Occupational exposure, bioterrorism incidents, consumption of contaminated food.
Prognosis:
The expected outcome or course of the condition over time.
Good with prompt supportive care; severe cases can result in complications or death if untreated.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Dehydration, respiratory failure, toxic shock syndrome.
Chronic Bacterial Prostatitis
Specialty: Infectious Diseases
Category: Bacterial Infections
Symptoms:
pain in the pelvic area; dysuria; frequent urination; painful ejaculation; recurrent urinary tract infections (utis)
Root Cause:
Persistent infection of the prostate gland by bacteria, most commonly Escherichia coli.
How it's Diagnosed: videos
Prostatic fluid culture. Urine tests before and after prostatic massage. Ultrasound or MRI for structural abnormalities.
Treatment:
Prolonged antibiotic therapy. Pain management and supportive care.
Medications:
Fluoroquinolones (e.g., ciprofloxacin or levofloxacin ). Trimethoprim-sulfamethoxazole (antibiotic combination).
Prevalence:
How common the health condition is within a specific population.
Common among men aged 30-50 years.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Previous prostate infections, urinary tract abnormalities, or a history of UTIs.
Prognosis:
The expected outcome or course of the condition over time.
Can be effectively treated with antibiotics, but recurrence is common.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic pain, abscess formation, infertility.
Corynebacterium Infections
Specialty: Infectious Diseases
Category: Bacterial Infections
Symptoms:
localized skin infections; pharyngitis; systemic symptoms in severe cases (e.g., diphtheria
Root Cause:
Infection caused by Corynebacterium species, including Corynebacterium diphtheriae or non-diphtherial strains.
How it's Diagnosed: videos
Throat or wound culture. PCR to detect toxin-producing strains.
Treatment:
Antibiotics and antitoxins for diphtheria. Supportive care in severe cases.
Medications:
Penicillin or erythromycin (macrolide antibiotic). Diphtheria antitoxin for toxin neutralization.
Prevalence:
How common the health condition is within a specific population.
Rare in developed countries due to vaccination; endemic in regions with poor immunization coverage.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Lack of vaccination, immunosuppression, close contact with infected individuals.
Prognosis:
The expected outcome or course of the condition over time.
Good with prompt treatment; untreated diphtheria can lead to death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Myocarditis, neuropathy, airway obstruction, and systemic toxin effects.
Cutibacterium (Propionibacterium) Infections
Specialty: Infectious Diseases
Category: Bacterial Infections
Symptoms:
redness; swelling; pain at infection site; pus formation; fever (in severe cases)
Root Cause:
Overgrowth of Cutibacterium acnes, a commensal bacterium, in a suitable anaerobic environment leading to infection. It often occurs with disrupted skin barriers, prosthetic devices, or surgical implants.
How it's Diagnosed: videos
Clinical examination, wound culture, imaging (if deep infections are suspected), and blood cultures in systemic cases.
Treatment:
Removal of infected implants or foreign material, debridement of infected tissue, and targeted antibiotic therapy.
Medications:
Antibiotics such as clindamycin (lincosamide), doxycycline (tetracycline ), or vancomycin (glycopeptide) are often prescribed. For severe cases, broad-spectrum antibiotics like piperacillin-tazobactam (penicillin-based beta-lactam) may be used.
Prevalence:
How common the health condition is within a specific population.
Rare; typically associated with post-surgical infections, acne, and prosthetic devices.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Surgical implants, compromised immune system, poor hygiene, acne-prone skin, and prior invasive procedures.
Prognosis:
The expected outcome or course of the condition over time.
Generally good with prompt diagnosis and treatment, but persistent or deep infections can require extended care.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Abscess formation, systemic infections, implant rejection, and chronic osteomyelitis.
Diphtheria
Specialty: Infectious Diseases
Category: Bacterial Infections
Sub-category: Respiratory Diseases
Symptoms:
sore throat; low-grade fever; difficulty breathing; thick, gray membrane over throat and tonsils; swollen neck (bull neck)
Root Cause:
Caused by Corynebacterium diphtheriae, which releases a toxin that inhibits protein synthesis in cells.
How it's Diagnosed: videos
Throat swab culture, polymerase chain reaction (PCR) for toxin genes, and clinical presentation.
Treatment:
Administration of diphtheria antitoxin and antibiotics. Isolation of the patient to prevent spread.
Medications:
Antibiotics like penicillin (beta-lactam) or erythromycin (macrolide) are typically prescribed to eradicate the bacteria.
Prevalence:
How common the health condition is within a specific population.
Rare in developed countries due to widespread vaccination, but endemic in certain low-resource settings.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Lack of vaccination, close contact with infected individuals, and living in unsanitary conditions.
Prognosis:
The expected outcome or course of the condition over time.
Good with early treatment; however, severe cases can lead to long-term complications or death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Airway obstruction, myocarditis, nerve damage, and systemic toxin effects.
Ehrlichiosis
Specialty: Infectious Diseases
Category: Bacterial Infections
Sub-category: Tick-Borne Diseases
Symptoms:
fever; headache; malaise; muscle aches; nausea; rash (less common)
Root Cause:
Infection by Ehrlichia species, transmitted by ticks, causing intracellular bacterial infection of white blood cells.
How it's Diagnosed: videos
Blood tests (PCR for Ehrlichia DNA, serology), complete blood count (CBC), and liver function tests.
Treatment:
Early initiation of antibiotic therapy and supportive care.
Medications:
Doxycycline (a tetracycline antibiotic) is the drug of choice.
Prevalence:
How common the health condition is within a specific population.
Found primarily in areas with high tick populations, particularly in the southeastern and south-central United States.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Tick exposure, outdoor activities in endemic areas, and lack of tick precautions.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with prompt treatment; delays can lead to severe or fatal complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Respiratory distress syndrome, organ failure, and secondary infections.
Elizabethkingia Infections
Specialty: Infectious Diseases
Category: Bacterial Infections
Sub-category: Nosocomial Infections
Symptoms:
fever; chills; shortness of breath; sepsis; localized infections such as cellulitis or endocarditis
Root Cause:
Caused by Elizabethkingia anophelis or Elizabethkingia meningoseptica, opportunistic pathogens that thrive in immunocompromised hosts, often transmitted in healthcare settings.
How it's Diagnosed: videos
Blood or tissue cultures, molecular identification techniques like MALDI-TOF MS, and PCR-based testing.
Treatment:
Targeted antibiotic therapy based on susceptibility testing, as the bacteria are often multidrug-resistant.
Medications:
Combination therapy may include vancomycin (glycopeptide), ciprofloxacin (fluoroquinolone), or trimethoprim-sulfamethoxazole (sulfonamide-antibiotic).
Prevalence:
How common the health condition is within a specific population.
Rare but increasingly reported in hospitalized and immunocompromised patients.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Hospitalization, invasive procedures, immunosuppression, and use of medical devices like ventilators or catheters.
Prognosis:
The expected outcome or course of the condition over time.
Variable; better outcomes with early diagnosis and appropriate therapy, though mortality is high in severe cases.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Sepsis, meningitis, endocarditis, and multi-organ failure.
Enterobacter Infections
Specialty: Infectious Diseases
Category: Bacterial Infections
Sub-category: Nosocomial Infections
Symptoms:
fever; chills; cough (if respiratory involvement); urinary symptoms (if uti); sepsis
Root Cause:
Infection caused by Enterobacter species, opportunistic bacteria often resistant to multiple antibiotics, frequently acquired in hospital settings.
How it's Diagnosed: videos
Blood cultures, urine cultures (for UTI), sputum cultures (for pneumonia), and susceptibility testing.
Treatment:
Removal of infected devices and initiation of tailored antibiotic therapy.
Medications:
Carbapenems like meropenem (beta-lactam), or ceftazidime-avibactam (beta-lactamase inhibitor combination) for resistant strains.
Prevalence:
How common the health condition is within a specific population.
Common in healthcare-associated infections, particularly in intensive care units.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Prolonged hospitalization, mechanical ventilation, immunosuppression, and prior antibiotic use.
Prognosis:
The expected outcome or course of the condition over time.
Good with timely and appropriate treatment, though resistant infections pose challenges.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Septic shock, abscess formation, and organ failure.
Enterococcal Infections
Specialty: Infectious Diseases
Category: Bacterial Infections
Sub-category: Nosocomial Infections
Symptoms:
fever; chills; urinary symptoms (if uti); abdominal pain (if intra-abdominal infection); sepsis
Root Cause:
Caused by Enterococcus faecalis or Enterococcus faecium, commensal bacteria that can become pathogenic in compromised hosts, often associated with antibiotic resistance.
How it's Diagnosed: videos
Blood cultures, urine cultures, or cultures from other infected sites, along with susceptibility testing.
Treatment:
Targeted antibiotic therapy often combined for synergy in severe infections.
Medications:
Ampicillin (beta-lactam) or vancomycin (glycopeptide) for susceptible strains; linezolid (oxazolidinone) or daptomycin (lipopeptide) for vancomycin-resistant enterococci (VRE).
Prevalence:
How common the health condition is within a specific population.
Common in hospitalized patients, particularly those with invasive devices or recent antibiotic use.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Prolonged hospitalization, use of indwelling catheters, immunosuppression, and prior antibiotic therapy.
Prognosis:
The expected outcome or course of the condition over time.
Good with effective treatment, but resistant infections require more complex management.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Bacteremia, endocarditis, intra-abdominal abscesses, and persistent infections.
Escherichia coli (E coli) Infections
Specialty: Infectious Diseases
Category: Bacterial Infections
Symptoms:
abdominal cramps; diarrhea (can be watery or bloody); nausea; vomiting; fever; fatigue
Root Cause:
Caused by specific strains of E. coli bacteria that produce toxins, leading to gastrointestinal or systemic infections.
How it's Diagnosed: videos
Stool culture, polymerase chain reaction (PCR) testing, and blood tests in severe cases to detect complications like hemolytic uremic syndrome (HUS).
Treatment:
Supportive care with hydration; antibiotics are used selectively, depending on the strain (e.g., avoid in Shiga toxin-producing E. coli). Severe cases may require hospitalization.
Medications:
Antibiotics such as ciprofloxacin (a fluoroquinolone) or TMP-SMX (a combination of trimethoprim and sulfamethoxazole ) for specific strains. Rehydration therapy with oral or IV solutions is critical.
Prevalence:
How common the health condition is within a specific population.
Common cause of foodborne illness worldwide, affecting millions annually.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Consumption of undercooked meat, unpasteurized milk, contaminated water, or poor hand hygiene.
Prognosis:
The expected outcome or course of the condition over time.
Generally resolves within a week for most cases. Complications like HUS can occur in 5–10% of Shiga toxin-producing E. coli infections, requiring intensive care.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Hemolytic uremic syndrome (HUS), kidney failure, dehydration, and sepsis in severe cases.
Group A Streptococcal (GAS) Infections
Specialty: Infectious Diseases
Category: Bacterial Infections
Symptoms:
sore throat; fever; red rash (scarlet fever); swollen lymph nodes; skin infections; muscle pain
Root Cause:
Caused by Streptococcus pyogenes bacteria, which produce toxins leading to localized or systemic infections.
How it's Diagnosed: videos
Throat culture, rapid antigen detection tests (RADT), and blood tests for severe infections.
Treatment:
Antibiotics are the mainstay, with supportive care for symptoms. Surgical intervention may be required for necrotizing fasciitis.
Medications:
Penicillin or amoxicillin (beta-lactam antibiotics) as first-line treatment. For penicillin-allergic patients, macrolides such as azithromycin or clindamycin can be prescribed.
Prevalence:
How common the health condition is within a specific population.
Widespread globally, affecting millions annually. Common in children and can lead to outbreaks in schools or communities.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Close contact with infected individuals, crowded living conditions, breaks in the skin.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with early treatment. Complications can arise if untreated, such as rheumatic fever or post-streptococcal glomerulonephritis.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Rheumatic fever, post-streptococcal glomerulonephritis, toxic shock syndrome, and necrotizing fasciitis.
Group B Streptococcus (GBS) Infections
Specialty: Infectious Diseases
Category: Bacterial Infections
Symptoms:
fever; difficulty breathing; lethargy; seizures in newborns; urinary tract infection symptoms in adults; joint or bone pain
Root Cause:
Caused by Streptococcus agalactiae bacteria, particularly in neonates during childbirth or in immunocompromised adults.
How it's Diagnosed: videos
Blood culture, cerebrospinal fluid (CSF) analysis, and urine culture. Pregnant women are screened at 35–37 weeks with rectovaginal swabs.
Treatment:
Intravenous antibiotics for active infections; prophylactic antibiotics during labor for colonized pregnant women.
Medications:
Penicillin G or ampicillin (beta-lactam antibiotics) are standard. Clindamycin may be used in penicillin-allergic individuals if susceptibility is confirmed.
Prevalence:
How common the health condition is within a specific population.
Found in 10–30% of pregnant women as vaginal or rectal colonizers. Neonatal GBS infections occur in 0.5–1 cases per 1,000 live births.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Maternal colonization, preterm labor, prolonged rupture of membranes, diabetes, or immunocompromised states.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with early detection and treatment. Mortality rates are higher in neonates and elderly adults with invasive infections.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Neonatal sepsis, pneumonia, meningitis, and long-term neurological sequelae in severe cases.
Group D Streptococcus (GDS) Infections
Specialty: Infectious Diseases
Category: Bacterial Infections
Symptoms:
fever; fatigue; abdominal pain; blood in stool; endocarditis symptoms (e.g., heart murmur); weight loss
Root Cause:
Caused by Streptococcus bovis or Streptococcus gallolyticus bacteria, often linked to colorectal cancer or endocarditis.
How it's Diagnosed: videos
Blood cultures, echocardiography (for endocarditis), and colonoscopy to screen for associated colorectal malignancy.
Treatment:
Prolonged antibiotic therapy; surgical intervention may be required for complications like valve damage.
Medications:
Penicillin G or ceftriaxone (a cephalosporin) for active infections. Vancomycin may be used for beta-lactam allergies.
Prevalence:
How common the health condition is within a specific population.
Rare compared to other streptococcal infections; associated with 15–65% of colorectal cancer cases.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Age over 50, colorectal malignancies, valvular heart disease, or immunocompromised conditions.
Prognosis:
The expected outcome or course of the condition over time.
Good with appropriate antibiotic treatment. However, prognosis may depend on the underlying colorectal malignancy or cardiac condition.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Endocarditis, septicemia, and undiagnosed colorectal cancer.
HACEK Group Infections
Specialty: Infectious Diseases
Category: Bacterial Infections
Symptoms:
fever; fatigue; heart murmurs; shortness of breath; night sweats; weight loss
Root Cause:
Infections caused by a group of fastidious Gram-negative bacteria (Haemophilus, Aggregatibacter, Cardiobacterium, Eikenella, Kingella) commonly associated with infective endocarditis.
How it's Diagnosed: videos
Blood cultures (may require prolonged incubation), echocardiography for suspected endocarditis, polymerase chain reaction (PCR) testing for specific bacterial identification.
Treatment:
Empirical broad-spectrum antibiotics followed by targeted antimicrobial therapy based on blood culture results; surgical intervention for complications such as heart valve damage.
Medications:
Antibiotics such as ceftriaxone (third-generation cephalosporin) or ampicillin (beta-lactam antibiotic) are the main treatments. In cases of penicillin allergy, fluoroquinolones like ciprofloxacin may be used.
Prevalence:
How common the health condition is within a specific population.
Rare, accounting for approximately 1–3% of cases of infective endocarditis.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Pre-existing heart valve disease, prosthetic heart valves, poor dental hygiene, immunocompromised state.
Prognosis:
The expected outcome or course of the condition over time.
Good with prompt treatment, though complications like heart valve damage can occur. Long-term outcomes depend on the presence of comorbidities and complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Heart valve destruction, abscess formation, systemic embolization, and relapse of infection.
Haemophilus Influenzae Infections
Specialty: Infectious Diseases
Category: Bacterial Infections
Symptoms:
fever; cough; shortness of breath; stiff neck; altered mental status; ear pain; sore throat; swelling in the face
Root Cause:
Caused by the bacterium Haemophilus influenzae, which can lead to respiratory infections, meningitis, or sepsis.
How it's Diagnosed: videos
Blood cultures, cerebrospinal fluid analysis (in meningitis cases), sputum cultures, and imaging for complications such as pneumonia.
Treatment:
Antibiotics targeting H. influenzae, supportive care for respiratory distress or meningitis symptoms, and vaccination for prevention.
Medications:
Cefotaxime or ceftriaxone (third-generation cephalosporins), or amoxicillin-clavulanate (beta-lactam/beta-lactamase inhibitor). Rifampin may be used for prophylaxis in close contacts of cases with invasive disease.
Prevalence:
How common the health condition is within a specific population.
Reduced significantly in countries with widespread vaccination, but still prevalent in unvaccinated populations. Non-typeable H. influenzae remains a common cause of respiratory infections.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Lack of vaccination, immunocompromised state, young age (infants), chronic pulmonary conditions.
Prognosis:
The expected outcome or course of the condition over time.
Generally good with prompt treatment, though complications can lead to increased morbidity and mortality.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Meningitis, sepsis, pneumonia, epiglottitis, and hearing loss (from meningitis).
Helicobacter Pylori Infection
Specialty: Infectious Diseases
Category: Gastrointestinal Tract and Intra-abdominal Infections
Symptoms:
abdominal pain; nausea; vomiting; bloating; loss of appetite; unintentional weight loss; dark or tarry stools (indicating bleeding)
Root Cause:
Chronic infection caused by Helicobacter pylori bacteria, leading to inflammation of the stomach lining and increased risk of peptic ulcers and gastric cancer.
How it's Diagnosed: videos
Urea breath test, stool antigen test, blood test for antibodies, endoscopy with biopsy.
Treatment:
Combination of antibiotics to eradicate the bacteria and proton pump inhibitors (PPIs) to reduce stomach acid.
Medications:
Antibiotics (e.g., amoxicillin , clarithromycin , metronidazole ) to kill the bacteria. Proton pump inhibitors (PPIs, e.g., omeprazole , lansoprazole ) to reduce stomach acid and promote healing. Bismuth subsalicylate (part of quadruple therapy) to protect the stomach lining.
Prevalence:
How common the health condition is within a specific population.
Affects approximately 50% of the global population; more common in developing countries due to poor sanitation.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Poor sanitation, contaminated food and water, close contact with an infected individual, family history of H. pylori infection.
Prognosis:
The expected outcome or course of the condition over time.
Eradication is successful in most cases with appropriate therapy; untreated infections can lead to complications like ulcers or gastric cancer.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Peptic ulcers, gastric cancer, chronic gastritis, iron-deficiency anemia.
Klebsiella Infections
Specialty: Infectious Diseases
Category: Bacterial Infections
Symptoms:
fever; cough with thick sputum; shortness of breath; abdominal pain; urinary symptoms; chills; fatigue
Root Cause:
Infections caused by Klebsiella species, primarily Klebsiella pneumoniae, leading to pneumonia, urinary tract infections, sepsis, and liver abscesses.
How it's Diagnosed: videos
Blood cultures, sputum cultures, urine cultures, imaging (chest X-ray, CT scan) for pneumonia or abscesses.
Treatment:
Targeted antibiotic therapy based on susceptibility testing; supportive care for severe infections.
Medications:
Carbapenems (e.g., meropenem or imipenem ) for multidrug-resistant strains; cephalosporins (e.g., ceftriaxone ) or fluoroquinolones (e.g., ciprofloxacin ) for susceptible strains. Colistin or tigecycline for extensively drug-resistant strains.
Prevalence:
How common the health condition is within a specific population.
Increasing incidence due to antibiotic resistance, particularly in healthcare settings.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Hospitalization, use of invasive devices (e.g., catheters), immunosuppression, diabetes, chronic lung disease.
Prognosis:
The expected outcome or course of the condition over time.
Varies; good with early diagnosis and appropriate treatment, but mortality rates are high in severe, resistant infections.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Septic shock, lung abscesses, liver abscesses, and antibiotic resistance.
Leptospirosis
Specialty: Infectious Diseases
Category: Bacterial Infections
Symptoms:
high fever; muscle pain; headache; vomiting; jaundice; red eyes; skin rash; abdominal pain
Root Cause:
Caused by infection with Leptospira species, transmitted through water contaminated by animal urine, often affecting the liver, kidneys, and lungs.
How it's Diagnosed: videos
Serology (e.g., microscopic agglutination test), polymerase chain reaction (PCR), or culture from blood, urine, or cerebrospinal fluid.
Treatment:
Antibiotics to clear the infection, supportive care for organ involvement, and management of complications such as kidney failure.
Medications:
Doxycycline or penicillin (for mild cases); intravenous ceftriaxone or penicillin G for severe cases.
Prevalence:
How common the health condition is within a specific population.
Common in tropical and subtropical regions, particularly after heavy rainfall or flooding.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Exposure to contaminated water, working with animals, poor sanitation, recreational water activities.
Prognosis:
The expected outcome or course of the condition over time.
Good with early treatment; severe cases (Weil's disease) have a higher risk of mortality.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Kidney damage, meningitis, liver failure, respiratory distress, and hemorrhage.
Listeria Monocytogenes Infection (Listeriosis)
Specialty: Infectious Diseases
Category: Bacterial Infections
Symptoms:
fever; muscle aches; nausea; diarrhea; stiff neck; confusion; loss of balance; convulsions
Root Cause:
Caused by the bacterium Listeria monocytogenes, typically through contaminated food. It invades host cells and can spread systemically, particularly affecting immunocompromised individuals.
How it's Diagnosed: videos
Blood cultures, cerebrospinal fluid (CSF) analysis, or stool cultures; polymerase chain reaction (PCR) testing for Listeria DNA.
Treatment:
Antibiotic therapy, supportive care for severe infections, and prevention through proper food handling.
Medications:
Ampicillin (penicillin-class antibiotic) is the first-line treatment; in cases of penicillin allergy, trimethoprim-sulfamethoxazole (sulfonamide-class antibiotic) can be used. For severe cases, combination therapy with gentamicin (aminoglycoside antibiotic) is recommended.
Prevalence:
How common the health condition is within a specific population.
Rare, with approximately 0.1–10 cases per million people annually; more common in pregnant women, neonates, the elderly, and immunocompromised individuals.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Consuming contaminated food (e.g., unpasteurized dairy, processed meats), weakened immune system, pregnancy, newborn status.
Prognosis:
The expected outcome or course of the condition over time.
Good with prompt treatment; however, untreated severe cases can lead to high mortality rates, especially in neonates and immunocompromised patients.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Meningitis, sepsis, miscarriage or stillbirth in pregnant women, encephalitis, and death in severe cases.
Meningococcemia
Specialty: Infectious Diseases
Category: Bacterial Infections
Sub-category: Systemic Infections
Symptoms:
fever; rash; cold extremities; rapid breathing; confusion; nausea; vomiting
Root Cause:
Caused by Neisseria meningitidis entering the bloodstream, leading to widespread vascular inflammation and potential sepsis.
How it's Diagnosed: videos
Blood cultures, CSF cultures, Gram stain, or PCR for Neisseria meningitidis DNA.
Treatment:
Immediate antibiotic therapy and supportive care, including fluid resuscitation and management of shock.
Medications:
Ceftriaxone or cefotaxime (cephalosporin-class antibiotics); penicillin G may also be used. Prophylaxis with rifampin (rifamycin-class antibiotic) or ciprofloxacin (fluoroquinolone-class antibiotic) for close contacts.
Prevalence:
How common the health condition is within a specific population.
Sporadic and epidemic cases worldwide; incidence varies widely depending on region and vaccination rates.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Crowded living conditions, immune deficiencies, close contact with infected individuals.
Prognosis:
The expected outcome or course of the condition over time.
Life-threatening without treatment; mortality can be reduced with prompt therapy, but survivors may face long-term complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Septic shock, disseminated intravascular coagulation (DIC), limb loss due to necrosis, neurological damage.
Moraxella Catarrhalis Infection
Specialty: Infectious Diseases
Category: Bacterial Infections
Sub-category: Respiratory Infections
Symptoms:
ear pain; fever; sinus pressure; cough; shortness of breath; purulent nasal discharge
Root Cause:
Caused by Moraxella catarrhalis, a gram-negative bacterium that primarily affects the respiratory tract.
How it's Diagnosed: videos
Clinical presentation, sputum culture, and polymerase chain reaction (PCR) testing.
Treatment:
Antibiotic therapy for symptomatic cases; supportive care for mild infections.
Medications:
Amoxicillin-clavulanate (penicillin-class antibiotic with beta-lactamase inhibitor), cefuroxime (cephalosporin-class antibiotic), or macrolides like azithromycin .
Prevalence:
How common the health condition is within a specific population.
Common cause of otitis media in children and respiratory tract infections in adults with chronic obstructive pulmonary disease (COPD).
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Age (young children, elderly), underlying respiratory conditions, and weakened immune systems.
Prognosis:
The expected outcome or course of the condition over time.
Generally good with appropriate treatment; mild cases often resolve without complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Middle ear infections, sinus infections, exacerbation of COPD, or pneumonia.
Morganella Infections
Specialty: Infectious Diseases
Category: Bacterial Infections
Sub-category: Opportunistic Infections
Symptoms:
fever; pain or burning during urination; cloudy or foul-smelling urine; wound infections showing redness and pus; sepsis symptoms in severe cases
Root Cause:
Caused by Morganella morganii, a gram-negative bacterium that is part of the normal gut flora but can become pathogenic, particularly in immunocompromised individuals.
How it's Diagnosed: videos
Blood cultures, urine cultures, or wound cultures; antibiotic susceptibility testing to guide treatment.
Treatment:
Antibiotic therapy tailored to susceptibility results; supportive care for systemic infections.
Medications:
Piperacillin-tazobactam (penicillin-class antibiotic with beta-lactamase inhibitor), cefepime (cephalosporin-class antibiotic), or carbapenems (e.g., meropenem ) for multidrug-resistant strains.
Prevalence:
How common the health condition is within a specific population.
Rare as a primary pathogen; more common as a secondary or opportunistic infection in hospital settings.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Hospitalization, catheter use, immunosuppression, diabetes, and recent antibiotic use.
Prognosis:
The expected outcome or course of the condition over time.
Good with appropriate treatment; however, delays in treatment can lead to severe complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Sepsis, multidrug resistance, urinary tract infections, and delayed wound healing.
Multiple Organ Dysfunction Syndrome in Sepsis (MODS)
Specialty: Infectious Diseases
Category: Systemic Syndromes
Sub-category: Critical Illnesses
Symptoms:
fever or hypothermia; rapid heart rate; low blood pressure; altered mental status; respiratory failure; kidney dysfunction; liver dysfunction
Root Cause:
Results from a dysregulated immune response to infection, leading to systemic inflammation, organ ischemia, and failure.
How it's Diagnosed: videos
Clinical criteria, laboratory tests showing organ dysfunction (e.g., elevated creatinine, bilirubin, lactate), and imaging for underlying infection.
Treatment:
Prompt treatment of the underlying infection, organ support (e.g., mechanical ventilation, dialysis), and management of sepsis.
Medications:
Broad-spectrum antibiotics such as piperacillin-tazobactam or meropenem initially; later adjusted based on culture results. Vasopressors like norepinephrine for septic shock.
Prevalence:
How common the health condition is within a specific population.
Common in intensive care units (ICUs) among patients with severe sepsis; mortality rates range from 30% to 50%.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Severe infections, immunosuppression, advanced age, and comorbidities like diabetes or cancer.
Prognosis:
The expected outcome or course of the condition over time.
Poor without aggressive treatment; prognosis depends on the number of organs involved and timeliness of intervention.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Multi-organ failure, prolonged ICU stay, secondary infections, and death.
Mycoplasma Infections (Mycoplasma pneumoniae)
Specialty: Infectious Diseases
Category: Bacterial Infections
Sub-category: Atypical Pneumonia
Symptoms:
persistent dry cough; fever; sore throat; fatigue; headache; mild chest pain
Root Cause:
Caused by Mycoplasma pneumoniae, a bacterium lacking a cell wall, making it resistant to many antibiotics and leading to atypical pneumonia.
How it's Diagnosed: videos
Clinical presentation, chest X-ray, PCR for Mycoplasma DNA, or serologic testing for antibodies.
Treatment:
Antibiotic therapy effective against atypical organisms and symptomatic relief.
Medications:
Azithromycin (macrolide antibiotic), doxycycline (tetracycline-class antibiotic), or levofloxacin (fluoroquinolone antibiotic).
Prevalence:
How common the health condition is within a specific population.
Responsible for 10–30% of community-acquired pneumonia cases; more common in younger populations, such as school-aged children and young adults.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Close contact in crowded settings (e.g., schools, dormitories), weakened immune system.
Prognosis:
The expected outcome or course of the condition over time.
Generally good with treatment; most patients recover within a few weeks.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Severe pneumonia, encephalitis, hemolytic anemia, and skin rashes like Stevens-Johnson syndrome.
Nocardiosis
Specialty: Infectious Diseases
Category: Bacterial Infections
Symptoms:
persistent cough; fever; fatigue; weight loss; skin lesions; difficulty breathing; chest pain
Root Cause:
Infection caused by Nocardia bacteria, often entering the body through inhalation or skin wounds.
How it's Diagnosed: videos
Identified via sputum or tissue culture, biopsy, and imaging studies like chest X-rays or CT scans.
Treatment:
Treatment includes long-term antibiotic therapy, sometimes combined with surgical drainage of abscesses.
Medications:
Trimethoprim-sulfamethoxazole (antibiotic combination used to treat bacterial infections) is the primary medication. Other antibiotics like linezolid or imipenem may be used in severe cases.
Prevalence:
How common the health condition is within a specific population.
Rare; occurs primarily in immunocompromised individuals.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Weakened immune system, organ transplantation, corticosteroid use, HIV/AIDS, or chronic lung diseases.
Prognosis:
The expected outcome or course of the condition over time.
Variable; good with early diagnosis and treatment but poor in disseminated cases or delayed diagnosis.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Dissemination to the brain (brain abscess), lungs, or other organs, leading to potentially life-threatening conditions.
Pasteurella Multocida Infection
Specialty: Infectious Diseases
Category: Bacterial Infections
Symptoms:
redness and swelling at the site of a wound; pain; fever; lymphadenopathy; pus formation; joint stiffness if near a joint
Root Cause:
Caused by Pasteurella multocida, commonly following animal bites or scratches.
How it's Diagnosed: videos
Clinical history of an animal bite, wound culture, and blood tests if systemic infection is suspected.
Treatment:
Antibiotic therapy and wound care; surgical debridement if necessary.
Medications:
Amoxicillin-clavulanate (antibiotic combination for bacterial infections) is first-line therapy; doxycycline or ciprofloxacin can be alternatives.
Prevalence:
How common the health condition is within a specific population.
Common in individuals exposed to animal bites or scratches.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Contact with pets or wild animals, especially cats and dogs.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with prompt treatment; untreated cases can result in severe complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Cellulitis, abscess formation, sepsis, or septic arthritis if untreated.
Peptostreptococcus Infection
Specialty: Infectious Diseases
Category: Bacterial Infections
Symptoms:
pain and swelling at the infection site; fever; abscess formation; foul-smelling drainage; systemic signs of infection
Root Cause:
Caused by Peptostreptococcus species, part of normal flora, but pathogenic in abscesses and infections.
How it's Diagnosed: videos
Identified through anaerobic culture of wound or abscess drainage, and imaging for deep abscesses.
Treatment:
Antibiotic therapy tailored to anaerobic bacteria, often combined with drainage of abscesses.
Medications:
Clindamycin (anaerobic infection treatment), metronidazole (antiprotozoal and anaerobic antibacterial), or carbapenems.
Prevalence:
How common the health condition is within a specific population.
Uncommon as a primary pathogen; often part of polymicrobial infections.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Poor dental hygiene, surgical procedures, trauma, or immunosuppression.
Prognosis:
The expected outcome or course of the condition over time.
Good with timely treatment; untreated infections may spread systemically.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Abscess rupture, osteomyelitis, septicemia, or endocarditis.
Plague
Specialty: Infectious Diseases
Category: Bacterial Infections
Symptoms:
fever; chills; headache; swollen lymph nodes (buboes); cough; shortness of breath; septic shock in severe cases
Root Cause:
Caused by Yersinia pestis, transmitted via flea bites or contact with infected animals.
How it's Diagnosed: videos
Confirmed by blood, sputum, or lymph node aspirate culture; rapid diagnostic tests for Yersinia pestis.
Treatment:
Early antibiotic therapy and supportive care are critical.
Medications:
Streptomycin (aminoglycoside) or gentamicin is the treatment of choice; alternatives include doxycycline or ciprofloxacin .
Prevalence:
How common the health condition is within a specific population.
Rare in modern times but endemic in some regions of Africa, Asia, and the Americas.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Flea exposure, handling infected animals, or residing in endemic regions.
Prognosis:
The expected outcome or course of the condition over time.
Good with prompt antibiotic treatment; high mortality in untreated cases.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Pneumonia, septicemia, and multi-organ failure.
Poststreptococcal Glomerulonephritis
Specialty: Infectious Diseases
Category: Immune-mediated Disorders
Symptoms:
swelling in the face and extremities; dark-colored urine; high blood pressure; fatigue; reduced urine output
Root Cause:
Immune response to Streptococcus infection leading to inflammation of glomeruli in the kidneys.
How it's Diagnosed: videos
Clinical history of recent strep infection, urine analysis (hematuria, proteinuria), and blood tests (low complement levels, elevated ASO titer).
Treatment:
Supportive care; addressing hypertension, fluid balance, and in rare cases, immunosuppressive therapy.
Medications:
Diuretics for fluid overload, antihypertensives (e.g., ACE inhibitors or ARBs) for blood pressure control. No direct antibiotic therapy unless active strep infection persists.
Prevalence:
How common the health condition is within a specific population.
More common in children following strep throat or skin infections.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Recent strep infections, especially in crowded or resource-limited settings.
Prognosis:
The expected outcome or course of the condition over time.
Usually resolves with supportive care; chronic kidney damage is rare.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Acute kidney injury, hypertensive encephalopathy, or nephrotic syndrome in severe cases.
Proteus Infections
Specialty: Infectious Diseases
Category: Bacterial Infections
Symptoms:
urinary tract infections (utis); fever; painful urination; abdominal pain; foul-smelling urine; wound infections; sepsis in severe cases
Root Cause:
Caused by the Proteus species, a genus of Gram-negative bacteria. Commonly associated with UTIs and hospital-acquired infections due to its ability to produce urease and form biofilms.
How it's Diagnosed: videos
Urine culture, blood culture, or wound culture; imaging (e.g., ultrasound or CT for abscesses or stones); antimicrobial susceptibility testing to identify effective antibiotics.
Treatment:
Antibiotic therapy based on culture sensitivity results; supportive care if systemic infection occurs; removal of infected devices or stones if present.
Medications:
Commonly prescribed antibiotics include ceftriaxone (third-generation cephalosporin), piperacillin-tazobactam (beta-lactam/beta-lactamase inhibitor), or ciprofloxacin (fluoroquinolone) for sensitive strains. Aminoglycosides like gentamicin may also be used for severe cases.
Prevalence:
How common the health condition is within a specific population.
Proteus infections are a common cause of hospital-acquired infections and account for 1-2% of community-acquired UTIs.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Indwelling catheters, immunosuppression, prolonged hospitalization, structural abnormalities of the urinary tract, previous antibiotic use.
Prognosis:
The expected outcome or course of the condition over time.
Good with prompt diagnosis and appropriate treatment. However, delays or resistance to treatment can lead to complications such as kidney stones, chronic infections, or sepsis.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Struvite stone formation, recurrent UTIs, abscesses, and sepsis.
Providencia Infections
Specialty: Infectious Diseases
Category: Bacterial Infections
Symptoms:
utis; fever; abdominal pain; burn wound infections; sepsis in immunocompromised patients
Root Cause:
Caused by Providencia species, Gram-negative bacteria with resistance to multiple antibiotics. Common in nosocomial infections and associated with biofilm formation.
How it's Diagnosed: videos
Urine, blood, or wound cultures; antimicrobial sensitivity testing.
Treatment:
Treatment with targeted antibiotics based on susceptibility results; removal of infected devices or management of underlying conditions.
Medications:
Effective antibiotics may include imipenem (carbapenem), amikacin (aminoglycoside), or cefepime (fourth-generation cephalosporin), depending on susceptibility.
Prevalence:
How common the health condition is within a specific population.
Rare but increasingly identified in healthcare-associated infections, especially in patients with urinary catheters.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Immunosuppression, long-term catheter use, extended hospital stays, prior antibiotic use.
Prognosis:
The expected outcome or course of the condition over time.
Can be challenging to treat due to multidrug resistance but favorable outcomes with appropriate antibiotic therapy.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Persistent UTIs, systemic infection, multi-organ failure in severe cases.
Pseudomonas Aeruginosa Infections
Specialty: Infectious Diseases
Category: Bacterial Infections
Symptoms:
skin infections; pneumonia; fever; wound infections; otitis externa (swimmer’s ear); sepsis in severe cases
Root Cause:
Caused by Pseudomonas aeruginosa, a highly adaptable Gram-negative pathogen known for antibiotic resistance and biofilm formation.
How it's Diagnosed: videos
Culture from infected sites (e.g., wound, sputum, urine); antimicrobial sensitivity testing.
Treatment:
Antibiotic therapy guided by susceptibility testing; surgical debridement for infected wounds; supportive care for severe infections.
Medications:
Common treatments include piperacillin-tazobactam, ceftazidime (third-generation cephalosporin), meropenem (carbapenem), or colistin (polymyxin ) for resistant strains.
Prevalence:
How common the health condition is within a specific population.
A leading cause of hospital-acquired infections; commonly affects immunocompromised patients.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Prolonged hospitalization, mechanical ventilation, burns, cystic fibrosis, neutropenia.
Prognosis:
The expected outcome or course of the condition over time.
Variable; depends on infection severity and resistance patterns. Severe infections can be life-threatening.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic infections, septicemia, and high mortality rates in multidrug-resistant cases.
Pseudotuberculosis
Specialty: Infectious Diseases
Category: Bacterial Infections
Symptoms:
fever; abdominal pain; diarrhea; mesenteric lymphadenitis mimicking appendicitis
Root Cause:
Caused by Yersinia pseudotuberculosis, a Gram-negative bacterium that primarily affects the gastrointestinal tract.
How it's Diagnosed: videos
Stool culture, blood culture, or serological testing.
Treatment:
Antibiotics for severe infections; supportive care for mild cases.
Medications:
Doxycycline (tetracycline ) or trimethoprim-sulfamethoxazole (sulfonamide) for systemic cases.
Prevalence:
How common the health condition is within a specific population.
Rare, with sporadic outbreaks often linked to contaminated food or water.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Consumption of contaminated food, exposure to infected animals, underlying immunodeficiency.
Prognosis:
The expected outcome or course of the condition over time.
Excellent for uncomplicated cases with supportive care. Severe cases respond well to antibiotic therapy.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Reactive arthritis, septicemia, and erythema nodosum.
Q Fever
Specialty: Infectious Diseases
Category: Bacterial Infections
Symptoms:
fever; severe headache; myalgia; cough; fatigue; chronic endocarditis in severe cases
Root Cause:
Caused by Coxiella burnetii, an obligate intracellular bacterium, primarily transmitted through aerosols from infected animals.
How it's Diagnosed: videos
Serological tests (e.g., phase I and II antibody titers), PCR for bacterial DNA, or culture in specialized laboratories.
Treatment:
Antibiotic therapy for acute and chronic cases; doxycycline is the mainstay treatment.
Medications:
Doxycycline (tetracycline ) combined with hydroxychloroquine (immunomodulator) for chronic Q fever; acute cases are treated with doxycycline alone.
Prevalence:
How common the health condition is within a specific population.
Rare but seen globally, particularly in individuals working with livestock.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Occupational exposure (e.g., farmers, veterinarians), proximity to livestock, immunosuppression.
Prognosis:
The expected outcome or course of the condition over time.
Acute Q fever typically resolves with treatment; chronic cases require prolonged therapy but may result in endocarditis.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic Q fever, endocarditis, vascular infections, and adverse pregnancy outcomes.
Relapsing Fever
Specialty: Infectious Diseases
Category: Bacterial Infections
Symptoms:
recurring episodes of high fever; chills; headaches; muscle and joint pain; nausea; vomiting; rash
Root Cause:
Caused by infection with Borrelia bacteria transmitted by lice (Louse-Borne Relapsing Fever) or soft-bodied ticks (Tick-Borne Relapsing Fever).
How it's Diagnosed: videos
Blood smear microscopy during febrile episodes, polymerase chain reaction (PCR) testing, or serological tests for Borrelia.
Treatment:
Antibiotics such as doxycycline or erythromycin; supportive care for symptoms like dehydration or electrolyte imbalance.
Medications:
Doxycycline (a tetracycline antibiotic), erythromycin (a macrolide antibiotic), or penicillin G (a beta-lactam antibiotic for severe cases).
Prevalence:
How common the health condition is within a specific population.
Rare in developed countries; more common in resource-limited settings, especially in Africa.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Exposure to tick- or louse-infested areas, living in crowded or unsanitary conditions, and travel to endemic regions.
Prognosis:
The expected outcome or course of the condition over time.
Good with timely treatment; symptoms resolve after antibiotic therapy, though Jarisch-Herxheimer reaction may occur shortly after treatment begins.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Jarisch-Herxheimer reaction, myocarditis, meningitis, multiorgan failure, or death if left untreated.
Rhodococcus Equi Infection
Specialty: Infectious Diseases
Category: Bacterial Infections
Symptoms:
chronic cough; fever; shortness of breath; weight loss; chest pain
Root Cause:
Caused by infection with Rhodococcus equi, a gram-positive bacterium that primarily affects immunocompromised individuals, such as those with HIV/AIDS or on immunosuppressive therapy.
How it's Diagnosed: videos
Blood cultures, sputum cultures, or imaging (chest X-ray or CT scan).
Treatment:
Prolonged antibiotic therapy, typically with a combination of a macrolide (e.g., azithromycin) and rifampin.
Medications:
Azithromycin (macrolide antibiotic), rifampin (rifamycin antibiotic), and sometimes vancomycin (glycopeptide antibiotic) for resistant cases.
Prevalence:
How common the health condition is within a specific population.
Rare; more common in areas with endemic livestock populations.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Immunosuppression, exposure to farm animals, or occupational exposure in agriculture.
Prognosis:
The expected outcome or course of the condition over time.
Variable; good with early diagnosis and treatment but potentially fatal in advanced or untreated cases.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Pulmonary abscesses, disseminated infection, or recurrence.
Rickettsialpox
Specialty: Infectious Diseases
Category: Bacterial Infections
Sub-category: Rickettsial Diseases
Symptoms:
fever; rash; eschar at the bite site; chills; malaise; headache
Root Cause:
Caused by infection with Rickettsia akari, transmitted through bites of infected mites (rodent-associated).
How it's Diagnosed: videos
Clinical presentation, serologic tests, or PCR testing of eschar material.
Treatment:
Doxycycline is the drug of choice.
Medications:
Doxycycline (tetracycline antibiotic); chloramphenicol (alternative in cases of contraindications).
Prevalence:
How common the health condition is within a specific population.
Sporadic outbreaks in urban environments with high rodent populations.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Contact with rodent-infested environments and mite bites.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with treatment; typically self-limiting without severe complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Rare; may include prolonged fever or secondary bacterial infections.
Rocky Mountain Spotted Fever (RMSF)
Specialty: Infectious Diseases
Category: Bacterial Infections
Sub-category: Rickettsial Diseases
Symptoms:
fever; headache; rash (starting on wrists and ankles); muscle aches; nausea; vomiting; confusion
Root Cause:
Caused by infection with Rickettsia rickettsii, transmitted by tick bites.
How it's Diagnosed: videos
Clinical presentation, serological testing, and PCR.
Treatment:
Immediate administration of doxycycline; treatment is started empirically based on suspicion.
Medications:
Doxycycline (tetracycline antibiotic); chloramphenicol (alternative for pregnant women in certain cases).
Prevalence:
How common the health condition is within a specific population.
Endemic in the Americas, particularly in the southeastern United States.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Exposure to tick-infested areas, lack of protective clothing during outdoor activities.
Prognosis:
The expected outcome or course of the condition over time.
Good with early treatment; delayed diagnosis can lead to severe complications or death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Multi-organ failure, disseminated intravascular coagulation (DIC), or long-term neurological deficits.
Serratia
Specialty: Infectious Diseases
Category: Bacterial Infections
Sub-category: Gram-Negative Bacteria
Symptoms:
urinary tract infections; pneumonia; wound infections; sepsis; red pigment in infections (serratia marcescens)
Root Cause:
Caused by Serratia species, opportunistic gram-negative bacteria often associated with healthcare-associated infections.
How it's Diagnosed: videos
Blood cultures, urine cultures, or imaging studies depending on the site of infection.
Treatment:
Broad-spectrum antibiotics based on sensitivity patterns; carbapenems are often effective.
Medications:
Imipenem (carbapenem antibiotic), ceftriaxone (third-generation cephalosporin), gentamicin (aminoglycoside antibiotic).
Prevalence:
How common the health condition is within a specific population.
Common nosocomial pathogen, particularly in immunocompromised patients.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Hospitalization, catheter use, immunosuppression, or prior antibiotic use.
Prognosis:
The expected outcome or course of the condition over time.
Variable; severe infections can have a high mortality rate without prompt treatment.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Sepsis, organ abscesses, or antibiotic resistance.
Spontaneous Bacterial Peritonitis (SBP)
Specialty: Infectious Diseases
Category: Bacterial Infections
Symptoms:
fever; abdominal pain; nausea; vomiting; altered mental status; diarrhea; low blood pressure; tachycardia
Root Cause:
Infection of the peritoneal fluid in patients with cirrhosis and ascites, often due to bacterial translocation from the gut.
How it's Diagnosed: videos
Diagnostic paracentesis showing ascitic fluid with polymorphonuclear leukocytes (PMN) >250 cells/mm³, positive bacterial cultures, and low protein levels in ascitic fluid.
Treatment:
Antibiotics, supportive care, and management of the underlying cirrhosis or liver disease.
Medications:
Empiric therapy typically includes third-generation cephalosporins (e.g., cefotaxime or ceftriaxone ). Fluoroquinolones (e.g., ciprofloxacin ) may be used for prophylaxis in high-risk patients.
Prevalence:
How common the health condition is within a specific population.
Affects 10-30% of patients with cirrhosis and ascites.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Advanced liver cirrhosis, low protein concentration in ascitic fluid, gastrointestinal bleeding, prior episodes of SBP.
Prognosis:
The expected outcome or course of the condition over time.
With prompt treatment, the mortality rate can be reduced, but the recurrence rate is high without prophylaxis.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Sepsis, hepatic encephalopathy, acute kidney injury, death.
Staphylococcal Infections
Specialty: Infectious Diseases
Category: Bacterial Infections
Sub-category: Skin and Soft Tissue Infections
Symptoms:
skin abscesses; boils; cellulitis; fever; chills; shortness of breath in systemic cases; sepsis
Root Cause:
Infections caused by Staphylococcus aureus or other Staphylococcus species, including MRSA (methicillin-resistant strains).
How it's Diagnosed: videos
Culture of blood, wound, or affected tissues; imaging for systemic infections.
Treatment:
Drainage of abscesses, antibiotic therapy tailored to sensitivity testing.
Medications:
Penicillinase-resistant penicillins (e.g., nafcillin ), cephalosporins, or MRSA-active antibiotics (e.g., vancomycin , daptomycin , or linezolid ).
Prevalence:
How common the health condition is within a specific population.
Common globally; community-acquired and hospital-acquired infections are significant health concerns.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Open wounds, surgical procedures, immune suppression, diabetes, hospital stays, and invasive devices like catheters.
Prognosis:
The expected outcome or course of the condition over time.
Generally good with early treatment; however, MRSA strains pose a higher risk of severe complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Sepsis, endocarditis, osteomyelitis, and toxic shock syndrome.
Stenotrophomonas Maltophilia
Specialty: Infectious Diseases
Category: Bacterial Infections
Sub-category: Nosocomial Infections
Symptoms:
fever; cough; shortness of breath; wound infections; urinary tract infections; sepsis in immunocompromised individuals
Root Cause:
Opportunistic infection caused by Stenotrophomonas maltophilia, often associated with hospital environments.
How it's Diagnosed: videos
Blood, sputum, or wound culture and susceptibility testing.
Treatment:
Targeted antibiotic therapy; supportive care.
Medications:
Trimethoprim-sulfamethoxazole (first-line), with alternatives including levofloxacin or minocycline based on resistance patterns.
Prevalence:
How common the health condition is within a specific population.
A rare cause of infection, primarily in hospitalized or immunocompromised patients.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Prolonged hospital stays, mechanical ventilation, central venous catheters, immunosuppressive therapy.
Prognosis:
The expected outcome or course of the condition over time.
Poor in critically ill or immunosuppressed patients; high mortality in systemic infections.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Sepsis, multi-organ failure, prolonged hospitalization.
Toxic Shock Syndrome (TSS)
Specialty: Infectious Diseases
Category: Bacterial Infections
Sub-category: Toxin-Mediated Illnesses
Symptoms:
fever; rash; low blood pressure; desquamation of skin; multisystem organ failure
Root Cause:
Toxins produced by Staphylococcus aureus or Streptococcus pyogenes leading to systemic inflammatory response.
How it's Diagnosed: videos
Clinical evaluation, cultures, and toxin identification.
Treatment:
Antibiotics, supportive care for shock, and surgical debridement if necessary.
Medications:
Clindamycin (inhibits toxin production) combined with vancomycin or penicillin for bacterial eradication. Intravenous immunoglobulin (IVIG) may be considered.
Prevalence:
How common the health condition is within a specific population.
Rare; associated with tampon use, wounds, or post-surgical infections.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Tampon use, wounds, surgical procedures, immune suppression.
Prognosis:
The expected outcome or course of the condition over time.
With early treatment, survival is high; delayed treatment increases mortality risk.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Multisystem organ failure, death.
Trachoma
Specialty: Infectious Diseases
Category: Bacterial Infections
Sub-category: Chronic Infections
Symptoms:
red eyes; discharge; pain; corneal scarring; vision loss in advanced stages
Root Cause:
Chronic infection with Chlamydia trachomatis, leading to conjunctival inflammation and scarring.
How it's Diagnosed: videos
Clinical signs, laboratory tests (nucleic acid amplification tests or cultures).
Treatment:
Antibiotics, improved sanitation, and surgery for advanced cases.
Medications:
Azithromycin (single-dose oral therapy) or tetracycline eye ointment .
Prevalence:
How common the health condition is within a specific population.
Leading cause of infectious blindness globally; endemic in resource-limited settings.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Poor hygiene, lack of access to clean water, crowded living conditions.
Prognosis:
The expected outcome or course of the condition over time.
Preventable with early treatment and improved hygiene; untreated cases can lead to irreversible blindness.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Blindness, corneal ulceration, chronic conjunctivitis.
Trench Fever
Specialty: Infectious Diseases
Category: Bacterial Infections
Symptoms:
recurrent fever; headache; muscle aches; bone pain (particularly in the shins); rash; fatigue
Root Cause:
Caused by Bartonella quintana, transmitted through body lice; bacteria infect endothelial cells and red blood cells.
How it's Diagnosed: videos
Blood tests to detect Bartonella quintana using PCR, serology, or culture; clinical history of exposure to lice.
Treatment:
Antibiotics such as doxycycline or erythromycin; supportive care for symptoms like fever and pain.
Medications:
Doxycycline (tetracycline class, broad-spectrum antibiotic); erythromycin (macrolide class, bacteriostatic antibiotic). Combination with gentamicin is sometimes recommended in severe cases.
Prevalence:
How common the health condition is within a specific population.
Rare in developed nations but persists in settings with poor hygiene; seen among homeless populations and in war-torn areas.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Poor sanitation, exposure to lice, homelessness, military service in unsanitary conditions.
Prognosis:
The expected outcome or course of the condition over time.
Typically good with treatment; symptoms can resolve within weeks, but chronic relapses may occur without appropriate care.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Endocarditis, chronic bacteremia, or recurrent episodes if untreated.
Treponematosis (Endemic Syphilis, Yaws, and Pinta)
Specialty: Infectious Diseases
Category: Bacterial Infections
Sub-category: Treponemal Diseases
Symptoms:
skin ulcers; bone and joint pain; skin discoloration (in pinta); progressive deformities in severe cases
Root Cause:
Caused by Treponema pallidum subspecies; spread through skin contact in non-sexual settings, primarily in tropical regions.
How it's Diagnosed: videos
Serologic tests (e.g., RPR, TPPA), dark-field microscopy of lesions, or PCR.
Treatment:
Penicillin G is the standard treatment; azithromycin or doxycycline may be alternatives.
Medications:
Benzathine penicillin G (beta-lactam antibiotic, long-acting); azithromycin (macrolide antibiotic, bacteriostatic ).
Prevalence:
How common the health condition is within a specific population.
Common in certain tropical regions, particularly among children; yaws affects over 70,000 individuals globally.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Living in tropical climates, lack of access to healthcare, poor hygiene.
Prognosis:
The expected outcome or course of the condition over time.
Excellent if treated early; untreated cases can lead to severe deformities and disability.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Bone and joint deformities, chronic skin ulceration, social stigma.
Typhoid Fever
Specialty: Infectious Diseases
Category: Bacterial Infections
Sub-category: Enteric Infections
Symptoms:
high fever; abdominal pain; diarrhea or constipation; headache; rash (rose spots); fatigue
Root Cause:
Caused by Salmonella enterica serotype Typhi, transmitted via contaminated food or water; bacteria invade intestinal lining and bloodstream.
How it's Diagnosed: videos
Blood, stool, or urine cultures; Widal test; PCR testing.
Treatment:
Antibiotics like ceftriaxone, azithromycin, or ciprofloxacin; hydration therapy.
Medications:
Ceftriaxone (third-generation cephalosporin, bactericidal); azithromycin (macrolide antibiotic); ciprofloxacin (fluoroquinolone class).
Prevalence:
How common the health condition is within a specific population.
Endemic in regions with poor sanitation, especially South Asia, with millions of cases annually.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Ingesting contaminated food or water, poor sanitation, traveling to endemic areas.
Prognosis:
The expected outcome or course of the condition over time.
Good with prompt antibiotic treatment; untreated cases have high mortality rates.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Intestinal perforation, sepsis, or chronic carrier state.
Typhus
Specialty: Infectious Diseases
Category: Bacterial Infections
Sub-category: Rickettsial Diseases
Symptoms:
high fever; severe headache; rash; muscle aches; confusion or delirium in severe cases
Root Cause:
Caused by Rickettsia species (e.g., R. prowazekii); transmitted by lice, fleas, or mites.
How it's Diagnosed: videos
Serologic tests, PCR, or biopsy of rash.
Treatment:
Antibiotics like doxycycline; supportive care for symptoms.
Medications:
Doxycycline (tetracycline class, broad-spectrum antibiotic); chloramphenicol (broad-spectrum antibiotic, alternative for severe cases).
Prevalence:
How common the health condition is within a specific population.
Rare in developed countries; outbreaks occur in areas of war or poor sanitation.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Exposure to lice or fleas, overcrowding, unsanitary conditions.
Prognosis:
The expected outcome or course of the condition over time.
Good with treatment; severe cases may lead to death without antibiotics.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Organ failure, severe dehydration, or neurological issues in untreated cases.
Vibrio Infections
Specialty: Infectious Diseases
Category: Bacterial Infections
Sub-category: Waterborne Diseases
Symptoms:
watery diarrhea; abdominal cramps; vomiting; fever; skin infections (in vibrio vulnificus)
Root Cause:
Caused by Vibrio species (e.g., V. cholerae, V. vulnificus), often linked to contaminated water or seafood.
How it's Diagnosed: videos
Stool culture, PCR, or serology for specific strains.
Treatment:
Antibiotics for severe cases, oral rehydration therapy (ORT) or IV fluids.
Medications:
Doxycycline (tetracycline class); ciprofloxacin (fluoroquinolone class); azithromycin (macrolide antibiotic).
Prevalence:
How common the health condition is within a specific population.
Common in regions with cholera outbreaks; V. vulnificus infections are rare but severe.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Consumption of raw seafood, exposure to contaminated water, weakened immunity.
Prognosis:
The expected outcome or course of the condition over time.
Generally good with prompt treatment; V. vulnificus infections can be fatal in high-risk patients.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Severe dehydration (cholera), septicemia, necrotizing fasciitis (V. vulnificus).
Yersinia Enterocolitica Infection
Specialty: Infectious Diseases
Category: Bacterial Infections
Sub-category: Enteric Infections
Symptoms:
diarrhea (sometimes bloody); abdominal pain mimicking appendicitis; fever; joint pain (reactive arthritis in some cases)
Root Cause:
Caused by Yersinia enterocolitica, often from contaminated pork, water, or dairy products.
How it's Diagnosed: videos
Stool culture, PCR, or serology.
Treatment:
Supportive care; antibiotics like ciprofloxacin or doxycycline for severe cases.
Medications:
Ciprofloxacin (fluoroquinolone class); doxycycline (tetracycline class); TMP-SMX (trimethoprim-sulfamethoxazole, combination antibiotic).
Prevalence:
How common the health condition is within a specific population.
Common in temperate climates, particularly among children; outbreaks are sporadic.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Consuming undercooked pork, contact with infected animals, poor hygiene.
Prognosis:
The expected outcome or course of the condition over time.
Good with treatment; self-limiting in most cases.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Reactive arthritis, erythema nodosum, or septicemia in immunocompromised individuals.
Arthritis as a Manifestation of Systemic Disease
Specialty: Infectious Diseases
Category: Bone and Joint Infections
Symptoms:
joint pain and swelling; stiffness; fever; fatigue; skin rashes (depending on systemic disease); organ-specific symptoms like dry eyes in sjögren’s syndrome or chest pain in lupus
Root Cause:
Arthritis caused by systemic diseases such as rheumatoid arthritis, lupus, Sjögren’s syndrome, or sarcoidosis, leading to immune-mediated inflammation in joints.
How it's Diagnosed: videos
Clinical evaluation, blood tests (e.g., ESR, CRP, rheumatoid factor, ANA), imaging (X-rays, MRI, or ultrasound of affected joints), and joint fluid analysis.
Treatment:
Treating the underlying systemic condition with disease-specific therapies and symptomatic management of arthritis.
Medications:
Medications may include nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids (e.g., prednisone ), disease-modifying antirheumatic drugs (DMARDs, e.g., methotrexate , hydroxychloroquine ), and biologics (e.g., TNF inhibitors like adalimumab or etanercept ).
Prevalence:
How common the health condition is within a specific population.
Varies by systemic condition; for example, rheumatoid arthritis affects about 1% of the population.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Autoimmune disorders, genetic predisposition, infections, and environmental factors such as smoking.
Prognosis:
The expected outcome or course of the condition over time.
Prognosis depends on the underlying condition but may include periods of remission and flares; early treatment improves outcomes.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic pain, joint deformities, disability, systemic organ damage, and increased risk of infections due to immunosuppressive therapy.
Nongonococcal Infectious Arthritis
Specialty: Infectious Diseases
Category: Bone and Joint Infections
Symptoms:
acute joint pain and swelling; fever; restricted joint movement; warmth and redness over the affected joint
Root Cause:
Bacterial infection (commonly Staphylococcus aureus) within a joint, leading to rapid destruction of cartilage and surrounding tissues.
How it's Diagnosed: videos
Joint aspiration and fluid analysis (Gram stain and culture), blood tests (elevated WBC, ESR, CRP), and imaging (X-rays, ultrasound, or MRI).
Treatment:
Prompt antibiotic therapy and drainage of the infected joint via needle aspiration or surgery.
Medications:
Antibiotics such as vancomycin (for MRSA) or ceftriaxone (for Gram-negative bacteria). Antibiotics are classified as bactericidal and targeted to the suspected organism.
Prevalence:
How common the health condition is within a specific population.
Incidence ranges from 2-10 per 100,000 people annually, more common in patients with joint replacements or compromised immunity.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Joint replacement surgery, immunosuppression, diabetes, intravenous drug use, and pre-existing joint disease.
Prognosis:
The expected outcome or course of the condition over time.
Favorable with early intervention; delayed treatment can lead to joint destruction and systemic sepsis.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Joint damage, osteomyelitis, septicemia, and chronic pain or disability.
Pott Disease (Tuberculous [TB] Spondylitis)
Specialty: Infectious Diseases
Category: Bone and Joint Infections
Symptoms:
chronic back pain; fever; weight loss; night sweats; progressive spinal deformity (kyphosis); neurological deficits in severe cases
Root Cause:
Tuberculosis infection of the spine caused by Mycobacterium tuberculosis, leading to destruction of vertebrae and potential spinal instability.
How it's Diagnosed: videos
Imaging (X-rays, MRI, or CT scan), biopsy of spinal tissue, and microbiological testing (acid-fast bacilli staining and culture).
Treatment:
Combination anti-tuberculosis therapy (ATT) for 6-12 months and surgical intervention in cases of neurological compromise or spinal instability.
Medications:
First-line anti-TB drugs including isoniazid , rifampin , pyrazinamide , and ethambutol . These are classified as antimycobacterial agents.
Prevalence:
How common the health condition is within a specific population.
Endemic in regions with high TB prevalence; incidence varies but accounts for about 1-2% of TB cases worldwide.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Immunosuppression (e.g., HIV), malnutrition, crowded living conditions, and poor healthcare access.
Prognosis:
The expected outcome or course of the condition over time.
Good with timely treatment; late diagnosis can lead to irreversible spinal deformities and neurological damage.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Spinal cord compression, paraplegia, kyphosis, chronic pain, and systemic TB spread.
Septic Arthritis of Native Joints Empiric Therapy
Specialty: Infectious Diseases
Category: Bone and Joint Infections
Symptoms:
joint pain and swelling; fever; limited range of motion; warmth over the joint; chills
Root Cause:
Acute infection of a native joint caused by bacterial pathogens, often leading to inflammation and joint destruction if untreated.
How it's Diagnosed: videos
Joint aspiration (synovial fluid analysis for culture, Gram stain, and cell count), blood cultures, imaging (X-ray, MRI, or ultrasound).
Treatment:
Initial empiric therapy with broad-spectrum intravenous antibiotics followed by targeted therapy based on culture results, joint drainage via aspiration or surgery, and supportive care.
Medications:
Empiric antibiotic therapy includes intravenous vancomycin (a glycopeptide antibiotic for Gram-positive coverage) and ceftriaxone (a third-generation cephalosporin for Gram-negative coverage).
Prevalence:
How common the health condition is within a specific population.
Rare but more common in individuals with risk factors such as immunosuppression, intravenous drug use, or joint disease.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Rheumatoid arthritis, joint trauma, recent joint surgery, diabetes, prosthetic joint presence, intravenous drug use, immunosuppression.
Prognosis:
The expected outcome or course of the condition over time.
Good with early diagnosis and treatment; delayed treatment may lead to joint damage or sepsis.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic joint damage, osteomyelitis, sepsis, and systemic spread of infection.
Septic Arthritis of Native Joints Organism-Specific Therapy
Specialty: Infectious Diseases
Category: Bone and Joint Infections
Symptoms:
joint pain and swelling; fever; warmth and redness over the joint; reduced joint mobility
Root Cause:
Bacterial infection of a joint with known pathogen identification requiring specific antimicrobial treatment.
How it's Diagnosed: videos
Synovial fluid analysis and culture for organism identification, blood cultures, imaging studies to assess joint involvement.
Treatment:
Pathogen-specific antibiotic therapy tailored to culture and sensitivity results, combined with joint drainage and supportive care.
Medications:
Antibiotic regimens vary depending on pathogen > Staphylococcus aureus - Nafcillin (beta-lactam antibiotic) or vancomycin for MRSA. Streptococcus species - Penicillin G or ceftriaxone . Gram-negative bacilli - Ceftriaxone or piperacillin-tazobactam (extended-spectrum beta-lactam).
Prevalence:
How common the health condition is within a specific population.
Rare but can occur in patients with predisposing factors like underlying arthritis or joint surgery.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Immunocompromised states, joint trauma, rheumatoid arthritis, prosthetic joints, intravenous drug use.
Prognosis:
The expected outcome or course of the condition over time.
Favorable with appropriate organism-targeted therapy; joint preservation is possible if treated early.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic arthritis, joint instability, systemic infection, or abscess formation.
Septic Arthritis of Prosthetic Joints Empiric Therapy
Specialty: Infectious Diseases
Category: Bone and Joint Infections
Symptoms:
persistent joint pain; swelling; erythema around the prosthetic joint; fever; drainage from the surgical site
Root Cause:
Bacterial infection involving a prosthetic joint, leading to inflammation and potential prosthesis failure.
How it's Diagnosed: videos
Synovial fluid aspiration with analysis, blood cultures, imaging (X-rays, MRI, or CT), and intraoperative cultures if revision surgery is performed.
Treatment:
Empiric antibiotic therapy covering likely pathogens, surgical debridement, prosthesis removal or replacement, and long-term targeted antibiotic therapy.
Medications:
Initial broad-spectrum antibiotics such as vancomycin (glycopeptide for MRSA) combined with ceftriaxone (third-generation cephalosporin for Gram-negative coverage).
Prevalence:
How common the health condition is within a specific population.
Increasing with the rise in joint replacement surgeries; occurs in about 1-2% of primary joint arthroplasties.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Prior joint replacement surgery, infection at other sites, poor surgical technique, immunosuppression.
Prognosis:
The expected outcome or course of the condition over time.
Improved with early intervention; prosthesis salvage is possible in some cases.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Prosthetic failure, chronic infection, systemic sepsis, or need for prosthesis revision.
Septic Arthritis of Prosthetic Joints Organism-Specific Therapy
Specialty: Infectious Diseases
Category: Bone and Joint Infections
Symptoms:
localized joint pain; erythema; swelling; chronic drainage; fever or chills
Root Cause:
Prosthetic joint infection with identified causative organism requiring tailored antimicrobial therapy.
How it's Diagnosed: videos
Culture and sensitivity testing of synovial fluid, blood cultures, imaging studies, and histopathological analysis during surgery.
Treatment:
Organism-specific antibiotics, prosthesis revision or resection, and long-term suppression with oral antibiotics in select cases.
Medications:
Methicillin-sensitive Staphylococcus aureus - Nafcillin or cefazolin . Methicillin-resistant Staphylococcus aureus (MRSA) - Vancomycin or daptomycin (lipopeptide antibiotic). Pseudomonas aeruginosa - Ceftazidime or cefepime (extended-spectrum beta-lactams).
Prevalence:
How common the health condition is within a specific population.
Occurs in about 2-3% of prosthetic joint replacements.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Immunosuppression, prior infection, prolonged surgical procedures, comorbidities like diabetes.
Prognosis:
The expected outcome or course of the condition over time.
Good with appropriate therapy but often requires complex surgical intervention.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Prosthesis failure, osteomyelitis, systemic spread of infection, and prolonged disability.
Viral Arthritis
Specialty: Infectious Diseases
Category: Bone and Joint Infections
Symptoms:
joint pain and stiffness; swelling; rash (in some cases); fever; fatigue
Root Cause:
Joint inflammation caused by viral infections (e.g., Parvovirus B19, hepatitis B, hepatitis C, chikungunya virus).
How it's Diagnosed: videos
Clinical history, serologic testing for viral antibodies, PCR for viral DNA/RNA, exclusion of bacterial causes.
Treatment:
Supportive care, addressing the underlying viral infection, and symptomatic management with NSAIDs.
Medications:
Antiviral therapy for specific viral infections (e.g., lamivudine for hepatitis B). Symptomatic relief with NSAIDs (nonsteroidal anti-inflammatory drugs) such as ibuprofen or naproxen .
Prevalence:
How common the health condition is within a specific population.
Variable depending on the viral etiology and geographic distribution.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Exposure to viruses, immunosuppression, poor hygiene, endemic regions.
Prognosis:
The expected outcome or course of the condition over time.
Self-limiting in most cases, with resolution as the viral infection subsides.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic arthritis, post-viral fatigue, or in rare cases, systemic involvement of the virus.
Bacterial Meningitis (Empiric Therapy)
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
fever; neck stiffness; severe headache; nausea; vomiting; photophobia; altered mental status; seizures
Root Cause:
Acute inflammation of the meninges caused by bacterial infection.
How it's Diagnosed: videos
Clinical examination, lumbar puncture with cerebrospinal fluid (CSF) analysis (showing elevated white cell count, low glucose, and high protein), blood cultures, and imaging (CT or MRI if indicated).
Treatment:
Empiric antibiotic therapy (before the causative organism is identified), adjunctive corticosteroids, and supportive care.
Medications:
Empiric therapy often includes ceftriaxone or cefotaxime (3rd generation cephalosporins, broad-spectrum antibiotics), vancomycin (to cover resistant strains), and ampicillin (to cover Listeria monocytogenes in specific populations). Corticosteroids like dexamethasone are used to reduce inflammation.
Prevalence:
How common the health condition is within a specific population.
Incidence varies by region and age group; approximately 2-5 cases per 100,000 people annually in developed countries.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Immunosuppression, head trauma, invasive procedures, close contact with infected individuals, crowded living conditions, and extremes of age (infants and elderly).
Prognosis:
The expected outcome or course of the condition over time.
With prompt treatment, mortality is 5-30%, but delays in therapy significantly worsen outcomes. Neurological sequelae like hearing loss can occur.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Sepsis, increased intracranial pressure, stroke, seizures, and long-term neurological damage.
Bacterial Meningitis (Organism-Specific Therapy)
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
fever; neck stiffness; severe headache; nausea; vomiting; photophobia; altered mental status; seizures
Root Cause:
Inflammation of the meninges caused by specific bacterial pathogens like Neisseria meningitidis, Streptococcus pneumoniae, or Listeria monocytogenes.
How it's Diagnosed: videos
Identification of causative organism through cerebrospinal fluid (CSF) culture or polymerase chain reaction (PCR), blood cultures, and gram staining.
Treatment:
Targeted antibiotic therapy based on organism and susceptibility, adjunctive corticosteroids in certain cases, and supportive measures.
Medications:
For Neisseria meningitidis - Ceftriaxone or cefotaxime (3rd generation cephalosporins). For Streptococcus pneumoniae - Vancomycin plus ceftriaxone or cefotaxime . For Listeria monocytogenes - Ampicillin or penicillin G, often combined with gentamicin . Corticosteroids (e.g., dexamethasone ) to reduce inflammatory response in specific cases.
Prevalence:
How common the health condition is within a specific population.
Variable depending on region and vaccination coverage; more common in low-resource settings.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Age, immunodeficiency, lack of vaccination, recent head trauma or surgery, and close contact with infected individuals.
Prognosis:
The expected outcome or course of the condition over time.
Depends on early identification and treatment; targeted therapy improves outcomes, but significant mortality and morbidity can occur in severe cases.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Neurological deficits, hearing loss, hydrocephalus, brain abscess, or death.
California Encephalitis
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
fever; headache; nausea; vomiting; seizures; lethargy; meningeal irritation; neurological impairments in severe cases
Root Cause:
Viral infection caused by California serogroup viruses (e.g., La Crosse virus), primarily transmitted through mosquito bites.
How it's Diagnosed: videos
Clinical evaluation, lumbar puncture with cerebrospinal fluid (CSF) analysis, serologic or PCR testing for viral RNA.
Treatment:
Supportive care including antipyretics, anticonvulsants, and management of intracranial pressure.
Medications:
No specific antiviral therapy; symptomatic treatment includes antipyretics like acetaminophen and anticonvulsants like levetiracetam .
Prevalence:
How common the health condition is within a specific population.
Rare; typically affects children and adolescents in endemic regions of the United States.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Exposure to mosquito bites, residence in or travel to endemic areas, outdoor activities during peak mosquito seasons.
Prognosis:
The expected outcome or course of the condition over time.
Most cases resolve with supportive care, but severe cases may lead to neurological sequelae or death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Seizures, cognitive impairment, behavioral changes, or chronic neurological deficits in severe cases.
Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)
Specialty: Infectious Diseases
Category: Neurological Autoimmune Disorders
Sub-category: Demyelinating Neuropathies
Symptoms:
progressive muscle weakness; sensory loss; areflexia; tingling sensations; difficulty walking or using limbs
Root Cause:
Autoimmune-mediated destruction of the myelin sheath surrounding peripheral nerves.
How it's Diagnosed: videos
Nerve conduction studies, electromyography (EMG), lumbar puncture with elevated CSF protein, and nerve biopsy if needed.
Treatment:
Immunomodulatory therapy including corticosteroids, intravenous immunoglobulin (IVIG), or plasmapheresis.
Medications:
Corticosteroids (e.g., prednisone ), IVIG (immune modulator), and immunosuppressants like azathioprine or rituximab in refractory cases.
Prevalence:
How common the health condition is within a specific population.
Affects approximately 1–8 per 100,000 individuals worldwide.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Age (more common in older adults), history of other autoimmune disorders, genetic predisposition.
Prognosis:
The expected outcome or course of the condition over time.
Variable; many respond to treatment but may require long-term therapy to maintain remission. Relapses are common.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Permanent neurological deficits, muscle atrophy, decreased mobility, and infections from long-term immunosuppression.
CNS Whipple Disease
Specialty: Infectious Diseases
Category: CNS Infections
Sub-category: Rare Bacterial Infections
Symptoms:
cognitive dysfunction; ophthalmoplegia; seizures; ataxia; headache; weight loss; joint pain
Root Cause:
Caused by Tropheryma whipplei, a rare bacterial infection leading to systemic and neurological symptoms.
How it's Diagnosed: videos
PCR testing for Tropheryma whipplei in CSF or tissue biopsy, histopathology with PAS-positive macrophages, and endoscopic biopsy of the duodenum.
Treatment:
Long-term antibiotic therapy, typically starting with intravenous ceftriaxone followed by oral trimethoprim-sulfamethoxazole for one year.
Medications:
Ceftriaxone (IV beta-lactam antibiotic) followed by oral trimethoprim-sulfamethoxazole (a sulfonamide antimicrobial combination).
Prevalence:
How common the health condition is within a specific population.
Extremely rare; precise prevalence is unknown but estimated at less than 1 per 1,000,000 people annually.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Middle-aged males, HLA-B27 positivity, and immunosuppression.
Prognosis:
The expected outcome or course of the condition over time.
Early treatment can lead to full recovery, but delayed diagnosis increases the risk of irreversible neurological damage.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Cognitive impairment, seizures, motor dysfunction, and death if untreated.
Cysticercosis (Pork Tapeworm Infection)
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
seizures; headaches; confusion; intracranial hypertension; vision changes; nausea; vomiting
Root Cause:
Infection with Taenia solium larvae, often acquired through ingestion of food or water contaminated with eggs of the pork tapeworm.
How it's Diagnosed: videos
MRI or CT scans to detect cysts in the brain, serologic tests (enzyme-linked immunoelectrotransfer blot), and patient history of exposure.
Treatment:
Combination of antiparasitic therapy, corticosteroids, and symptomatic treatment. Surgery may be required in some cases to remove cysts or relieve pressure.
Medications:
Antiparasitic medications include albendazole or praziquantel (antihelminthic drugs). Corticosteroids such as dexamethasone or prednisone are used to control inflammation. Antiepileptic drugs (e.g., phenytoin , carbamazepine ) are prescribed to manage seizures.
Prevalence:
How common the health condition is within a specific population.
Endemic in developing countries, particularly in areas with poor sanitation and where pigs are raised. Prevalence varies widely but is common in parts of Latin America, Africa, and Asia.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Consumption of undercooked pork, poor sanitation, exposure to feces contaminated with Taenia solium eggs.
Prognosis:
The expected outcome or course of the condition over time.
With prompt diagnosis and treatment, prognosis is generally good, although chronic neurological effects may persist in severe cases.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Hydrocephalus, chronic seizures, encephalitis, and death in severe untreated cases.
Eastern Equine Encephalitis (EEE)
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
high fever; stiff neck; severe headache; vomiting; drowsiness; confusion; seizures; coma
Root Cause:
Infection caused by the Eastern Equine Encephalitis virus (EEEV), transmitted through the bite of an infected mosquito.
How it's Diagnosed: videos
Diagnosis is made through serologic tests (detection of IgM antibodies in cerebrospinal fluid or serum), PCR, or viral isolation from samples.
Treatment:
Supportive care, including respiratory support, anticonvulsants for seizures, and fluids for dehydration. No specific antiviral treatment is available.
Medications:
No direct antiviral medications; symptomatic treatments include anticonvulsants (e.g., levetiracetam or valproic acid) and medications to manage complications such as swelling in the brain (e.g., mannitol or corticosteroids).
Prevalence:
How common the health condition is within a specific population.
Rare but more common in the eastern United States, primarily in areas with wetland habitats. Annual cases are low, typically fewer than 10 per year in the U.S.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Living in or traveling to areas with high mosquito populations, outdoor exposure without protective measures.
Prognosis:
The expected outcome or course of the condition over time.
High mortality rate (approximately 30%); survivors often have long-term neurological sequelae.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Severe neurological damage, paralysis, intellectual disability, and death.
Haemophilus Meningitis
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
fever; stiff neck; headache; nausea; vomiting; sensitivity to light; altered mental status; seizures
Root Cause:
Bacterial infection caused by Haemophilus influenzae type b (Hib), leading to inflammation of the meninges.
How it's Diagnosed: videos
Lumbar puncture for cerebrospinal fluid analysis, Gram staining, and culture; PCR tests for Hib DNA.
Treatment:
Intravenous antibiotics and supportive care.
Medications:
Third-generation cephalosporins like ceftriaxone or cefotaxime are the antibiotics of choice. Adjunctive dexamethasone may be used to reduce inflammation.
Prevalence:
How common the health condition is within a specific population.
Rare in countries with widespread Hib vaccination; still occurs in unvaccinated populations or areas with low vaccine coverage.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Lack of vaccination, young age (children under 5), weakened immune system.
Prognosis:
The expected outcome or course of the condition over time.
With prompt antibiotic treatment, prognosis is good, although complications such as hearing loss may occur.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Hearing loss, intellectual disability, seizures, and death if untreated.
Herpes Simplex Encephalitis
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
fever; headache; altered mental status; seizures; personality changes; weakness; memory disturbances
Root Cause:
Viral infection caused by herpes simplex virus (HSV-1 or HSV-2), leading to inflammation and damage to brain tissue.
How it's Diagnosed: videos
MRI showing temporal lobe abnormalities, CSF analysis with PCR to detect HSV DNA, and EEG.
Treatment:
Antiviral therapy with supportive care.
Medications:
Acyclovir (antiviral medication) is the first-line treatment.
Prevalence:
How common the health condition is within a specific population.
Rare but serious, with an incidence of approximately 2–4 cases per million per year.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Prior HSV infections, immunosuppression, neonates (HSV-2), and older adults.
Prognosis:
The expected outcome or course of the condition over time.
Without treatment, mortality exceeds 70%; with prompt antiviral therapy, mortality is reduced to around 20%, though neurological sequelae are common.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Persistent neurological deficits, cognitive impairments, seizures, and death if untreated.
Infectious Myositis
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
muscle pain; swelling; weakness; fever; redness or warmth over affected muscles
Root Cause:
Infection of skeletal muscle caused by bacteria (e.g., Staphylococcus aureus), viruses (e.g., influenza), parasites (e.g., Trichinella spiralis), or fungi.
How it's Diagnosed: videos
Blood tests (elevated creatine kinase), imaging (MRI, ultrasound), and muscle biopsy.
Treatment:
Antibiotics for bacterial infections, antivirals for viral causes, antiparasitic medications, or antifungal drugs, depending on the underlying organism.
Medications:
Antibiotics such as clindamycin or vancomycin for bacterial infections; antiparasitic drugs like albendazole for parasitic causes; antifungal agents like amphotericin B for fungal infections.
Prevalence:
How common the health condition is within a specific population.
Rare; varies depending on the causative organism and geographic region.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Recent infections, immunosuppression, trauma to muscle, travel to endemic areas (for parasitic causes).
Prognosis:
The expected outcome or course of the condition over time.
Generally good with appropriate treatment; untreated cases can lead to severe complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Abscess formation, sepsis, rhabdomyolysis, and systemic spread of infection.
Intracranial Epidural Abscess
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
severe headache; nausea and vomiting; fever; seizures; neurological deficits; confusion or altered mental status
Root Cause:
A collection of pus between the skull and the dura mater, often caused by bacterial infection from sinusitis, otitis media, or trauma.
How it's Diagnosed: videos
Diagnosed through imaging (MRI or CT scan) and laboratory studies, including blood cultures and cerebrospinal fluid (CSF) analysis (if necessary).
Treatment:
Surgical drainage of the abscess combined with targeted antibiotic therapy.
Medications:
Antibiotics such as vancomycin and ceftriaxone (broad-spectrum) or metronidazole (for anaerobic coverage). These are antimicrobial agents tailored to the suspected causative organisms.
Prevalence:
How common the health condition is within a specific population.
Rare, accounting for less than 1% of all intracranial infections.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Chronic sinusitis, otitis media, head trauma, neurosurgical procedures, and immunosuppression.
Prognosis:
The expected outcome or course of the condition over time.
Generally good with prompt surgical and medical treatment, but delayed intervention can lead to permanent neurological damage or death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Meningitis, brain abscess, venous sinus thrombosis, or neurological deficits.
Japanese Encephalitis
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
fever; headache; nausea and vomiting; seizures; confusion; movement disorders; coma in severe cases
Root Cause:
Viral infection caused by the Japanese encephalitis virus (JEV), transmitted by Culex mosquitoes, leading to inflammation of the brain.
How it's Diagnosed: videos
Diagnosed through serological tests like IgM antibody capture ELISA (MAC-ELISA) in CSF or blood samples, and imaging (MRI).
Treatment:
Supportive care to manage symptoms, such as antipyretics for fever and anticonvulsants for seizures. No specific antiviral treatment.
Medications:
Supportive medications include anticonvulsants (e.g., phenytoin or levetiracetam ) and antipyretics (e.g., acetaminophen ). These are symptom-relieving drugs.
Prevalence:
How common the health condition is within a specific population.
Endemic in parts of Asia and the Western Pacific; affects approximately 50,000–100,000 people annually.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Living in or traveling to endemic areas, exposure to mosquito bites, and lack of vaccination.
Prognosis:
The expected outcome or course of the condition over time.
Mortality rate is 20–30%, and 30–50% of survivors have significant neurological or psychiatric sequelae.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Seizures, permanent neurological disabilities, movement disorders, and behavioral issues.
Meningococcal Meningitis
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
sudden onset of fever; severe headache; stiff neck; nausea and vomiting; photophobia; altered mental status; petechial or purpuric rash
Root Cause:
Bacterial infection caused by Neisseria meningitidis, leading to inflammation of the meninges and potential systemic involvement.
How it's Diagnosed: videos
Confirmed through lumbar puncture (CSF analysis for Gram stain and culture) and blood cultures; PCR testing for rapid identification.
Treatment:
Empiric antibiotic therapy with third-generation cephalosporins (e.g., ceftriaxone) and close-contact prophylaxis with rifampin or ciprofloxacin.
Medications:
Antibiotics - Ceftriaxone or penicillin G (specific antimicrobial therapy). Corticosteroids - Dexamethasone (adjunct to reduce inflammation). Prophylactic - Rifampin , ciprofloxacin , or ceftriaxone for close contacts.
Prevalence:
How common the health condition is within a specific population.
Incidence varies globally; outbreaks are common in the African meningitis belt.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Crowded living conditions, close contact with an infected person, smoking, and complement deficiencies.
Prognosis:
The expected outcome or course of the condition over time.
Mortality rate is 10–15% even with treatment; survivors may have permanent disabilities.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Septicemia, limb gangrene, disseminated intravascular coagulation (DIC), hearing loss, and brain damage.
Naegleria Infection and Primary Amebic Meningoencephalitis (PAM)
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
severe headache; fever; nausea; vomiting; stiff neck; seizures; altered mental status; hallucinations; coma
Root Cause:
Infection caused by the amoeba Naegleria fowleri, which invades the brain through the nasal passages, often following freshwater exposure.
How it's Diagnosed: videos
Analysis of cerebrospinal fluid (CSF) through lumbar puncture, identification of Naegleria in CSF via microscopy, polymerase chain reaction (PCR), or antigen testing; brain imaging (MRI or CT) for inflammation.
Treatment:
Aggressive antimicrobial therapy including amphotericin B (intravenous and intrathecal), supportive care for cerebral edema, and experimental medications like miltefosine.
Medications:
Amphotericin B (antifungal), miltefosine (antiparasitic), rifampin (antibiotic), fluconazole (antifungal), and azithromycin (antibiotic). These medications aim to target the amoeba directly and reduce associated inflammation.
Prevalence:
How common the health condition is within a specific population.
Rare; fewer than 150 cases reported in the United States over several decades. Occurs more frequently in warm climates with freshwater exposure.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Freshwater swimming or diving, particularly in warm lakes or hot springs; use of untreated water for nasal irrigation.
Prognosis:
The expected outcome or course of the condition over time.
Poor, with a mortality rate exceeding 97%; early diagnosis and treatment are critical for the few known survivors.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Rapidly progressing brain inflammation, brain herniation, coma, and death.
Neonatal Meningitis
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
fever; lethargy; poor feeding; irritability; seizures; bulging fontanel; stiff neck; vomiting; difficulty breathing
Root Cause:
Bacterial or viral infection in the meninges of the brain and spinal cord, often caused by pathogens like Group B Streptococcus, E. coli, or Listeria monocytogenes.
How it's Diagnosed: videos
Lumbar puncture for CSF analysis (elevated white cells, protein, decreased glucose), blood cultures, neuroimaging (MRI or CT), and specific PCR tests for pathogens.
Treatment:
Intravenous broad-spectrum antibiotics (e.g., ampicillin and gentamicin) followed by pathogen-specific therapy; antiviral medications for viral causes; supportive care for seizures and hydration.
Medications:
Antibiotics such as ampicillin (penicillin class), gentamicin (aminoglycoside), cefotaxime (cephalosporin), and acyclovir (antiviral for suspected herpes infection).
Prevalence:
How common the health condition is within a specific population.
Occurs in 1-3 cases per 1,000 live births in developed countries, higher prevalence in low-resource settings.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Premature birth, maternal infection, prolonged labor, low birth weight, and exposure to group B strep during delivery.
Prognosis:
The expected outcome or course of the condition over time.
Variable; high risk of mortality (10-15%) and neurodevelopmental sequelae in survivors (e.g., hearing loss, cerebral palsy).
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Sepsis, brain abscesses, hydrocephalus, and developmental delays.
Neurological Sequelae of Infectious Endocarditis
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
stroke-like symptoms; seizures; headache; altered mental status; focal neurological deficits; meningismus
Root Cause:
Embolic events or septic emboli originating from the infected cardiac valves can cause ischemic or hemorrhagic strokes, abscesses, and inflammation in the central nervous system (CNS).
How it's Diagnosed: videos
Clinical history, blood cultures to identify causative organism, imaging studies like MRI or CT to detect CNS involvement, echocardiography (transesophageal preferred) to assess for vegetations on heart valves.
Treatment:
Combination of prolonged intravenous antibiotics tailored to the causative organism, surgical intervention for infected valves if indicated, and supportive care for neurological complications.
Medications:
Antibiotics such as ceftriaxone , vancomycin , or gentamicin , depending on the identified pathogen (beta-lactams, glycopeptides, or aminoglycosides, respectively). Antiepileptics (e.g., levetiracetam ) if seizures occur.
Prevalence:
How common the health condition is within a specific population.
Rare but significant; approximately 20–40% of patients with infectious endocarditis develop neurological complications.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Intravenous drug use, pre-existing heart valve disease, prosthetic heart valves, immunosuppression, poor dental hygiene.
Prognosis:
The expected outcome or course of the condition over time.
Prognosis depends on promptness of treatment and severity of neurological complications; early intervention improves outcomes, but severe neurological deficits may persist.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Ischemic stroke, cerebral abscess, intracranial hemorrhage, meningitis, persistent neurological deficits, and risk of recurrent endocarditis.
Prion-Related Diseases
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
rapidly progressive dementia; ataxia; myoclonus; visual disturbances; behavioral changes; seizures in advanced cases
Root Cause:
Accumulation of abnormal prion proteins (PrP^Sc) in the brain leads to neurodegeneration, forming sponge-like brain tissue changes.
How it's Diagnosed: videos
Clinical history, EEG (showing periodic sharp wave complexes in some cases), MRI brain (characteristic signal changes in basal ganglia and cortex), CSF biomarkers (e.g., 14-3-3 protein), and definitive diagnosis by brain biopsy or post-mortem examination.
Treatment:
No curative treatment; management is supportive, focusing on symptom relief and palliative care.
Medications:
Symptomatic medications such as clonazepam or valproate for myoclonus and antipsychotics for behavioral symptoms. No specific disease-modifying drugs are available .
Prevalence:
How common the health condition is within a specific population.
Extremely rare; sporadic Creutzfeldt-Jakob Disease (sCJD) occurs in approximately 1–2 cases per million people per year.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Family history of prion diseases, exposure to infected tissue (e.g., through surgical instruments or contaminated beef in bovine spongiform encephalopathy).
Prognosis:
The expected outcome or course of the condition over time.
Poor prognosis; typically fatal within months to a year of symptom onset.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Rapid neurodegeneration, complete loss of cognitive and motor functions, and death.
Ramsay Hunt Syndrome
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
painful vesicular rash around the ear; facial paralysis on the affected side; hearing loss; tinnitus; vertigo; loss of taste on the anterior two-thirds of the tongue
Root Cause:
Reactivation of the varicella-zoster virus (VZV) in the geniculate ganglion of the facial nerve.
How it's Diagnosed: videos
Clinical presentation (facial paralysis and vesicular rash), PCR testing of vesicular fluid for VZV, MRI to exclude other causes of facial nerve palsy if needed.
Treatment:
Antiviral therapy (e.g., acyclovir or valacyclovir), corticosteroids (e.g., prednisone) to reduce inflammation, analgesics for pain management.
Medications:
Antivirals (e.g., acyclovir , valacyclovir ), corticosteroids (e.g., prednisone ), and pain management medications (e.g., gabapentin , opioids if severe).
Prevalence:
How common the health condition is within a specific population.
Rare; accounts for 12% of all facial paralysis cases.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Advanced age, immunosuppression, history of varicella infection.
Prognosis:
The expected outcome or course of the condition over time.
Recovery of facial nerve function occurs in 70–90% of cases with early treatment; delayed treatment or severe initial symptoms reduce the likelihood of full recovery.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Permanent facial weakness, hearing loss, post-herpetic neuralgia, and eye damage due to incomplete eyelid closure.
Skull Base, Petrous Apex, Infection
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
persistent headache; cranial nerve palsies (iii, iv, vi); ear pain; otorrhea; facial pain; fever
Root Cause:
Infection involving the petrous apex of the temporal bone, often resulting from chronic otitis media, mastoiditis, or direct extension of skull base infections.
How it's Diagnosed: videos
Imaging with CT or MRI to evaluate the extent of infection, blood cultures to identify causative organisms, and sometimes biopsy of infected tissue.
Treatment:
Prolonged course of intravenous antibiotics tailored to the pathogen, possible surgical drainage or debridement if abscess or extensive bony involvement occurs.
Medications:
Broad-spectrum antibiotics such as ceftriaxone or piperacillin-tazobactam initially, adjusted based on culture results. Antifungal agents (e.g., voriconazole ) if fungal infection is suspected.
Prevalence:
How common the health condition is within a specific population.
Rare due to the availability of antibiotics for otitis media; typically seen in immunocompromised individuals or those with delayed treatment.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Chronic ear infections, skull trauma, immunosuppression, and inadequate treatment of preceding infections.
Prognosis:
The expected outcome or course of the condition over time.
With timely treatment, good prognosis; delayed or untreated cases can lead to serious complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Cranial nerve damage, brain abscess, meningitis, and cavernous sinus thrombosis.
Spinal Epidural Abscess
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
fever; localized back pain; neurological deficits (e.g., weakness, numbness, or paralysis); difficulty walking; bowel or bladder dysfunction
Root Cause:
Accumulation of pus in the epidural space of the spine, typically caused by bacterial infection (commonly Staphylococcus aureus).
How it's Diagnosed: videos
Magnetic Resonance Imaging (MRI) with contrast; blood cultures; complete blood count (CBC); inflammatory markers like C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR).
Treatment:
Prompt surgical drainage and antibiotic therapy.
Medications:
Broad-spectrum antibiotics such as vancomycin (glycopeptide class) combined with ceftriaxone (cephalosporin class) or piperacillin-tazobactam (penicillin/beta-lactamase inhibitor class). Adjusted based on culture and sensitivity results.
Prevalence:
How common the health condition is within a specific population.
Rare; incidence estimated at 2-3 cases per 10,000 hospital admissions annually.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Diabetes, intravenous drug use, spinal trauma or surgery, immunosuppression, bacteremia or sepsis.
Prognosis:
The expected outcome or course of the condition over time.
Good with early diagnosis and treatment; delayed intervention can lead to permanent neurological deficits or death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Paralysis, chronic pain, sepsis, spinal instability, recurrent infections.
Spinal Infections
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
back pain; fever; neurological deficits; localized tenderness; malaise
Root Cause:
Infections of spinal tissues caused by bacteria, fungi, or, rarely, viruses.
How it's Diagnosed: videos
MRI with contrast, blood cultures, biopsy of infected tissue, inflammatory markers (CRP, ESR).
Treatment:
Antibiotics or antifungal agents; sometimes surgical intervention for abscess drainage or decompression.
Medications:
Antibiotics such as vancomycin (glycopeptide) for gram-positive organisms; ceftriaxone (cephalosporin) or piperacillin-tazobactam for gram-negative bacteria. For fungal infections, amphotericin B or fluconazole (antifungal agents).
Prevalence:
How common the health condition is within a specific population.
Rare; incidence depends on the specific condition within spinal infections.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Immunosuppression, diabetes, intravenous drug use, recent surgery, systemic infections.
Prognosis:
The expected outcome or course of the condition over time.
Good with timely treatment; delays can lead to permanent neurological damage.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Neurological deficits, chronic infection, sepsis, spinal deformities.
St. Louis Encephalitis
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
fever; headache; stiff neck; disorientation; tremors; seizures; coma in severe cases
Root Cause:
Viral infection caused by the St. Louis encephalitis virus (SLEV), transmitted by mosquitoes.
How it's Diagnosed: videos
Detection of SLEV-specific IgM antibodies in serum or cerebrospinal fluid (CSF) via ELISA; polymerase chain reaction (PCR).
Treatment:
Supportive care; no specific antiviral treatment.
Medications:
Symptomatic treatments, including antipyretics (e.g., acetaminophen ), anticonvulsants for seizures, and corticosteroids for severe inflammation (if indicated).
Prevalence:
How common the health condition is within a specific population.
Sporadic outbreaks in North America, particularly in the summer and early fall.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Mosquito exposure, older age, immunosuppression, residing in endemic areas.
Prognosis:
The expected outcome or course of the condition over time.
Varies; mild cases recover fully, while severe cases may have residual neurological deficits or mortality.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Persistent neurological issues, cognitive deficits, mortality in severe cases.
Staphylococcal Meningitis
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
fever; severe headache; neck stiffness; nausea; vomiting; altered mental status; seizures
Root Cause:
Infection of the meninges caused by Staphylococcus aureus or other staphylococcal species, often following surgery, trauma, or bacteremia.
How it's Diagnosed: videos
Lumbar puncture with CSF analysis; Gram staining and culture; blood cultures.
Treatment:
Intravenous antibiotics tailored to culture sensitivity.
Medications:
Empiric therapy often includes vancomycin (glycopeptide) combined with ceftriaxone or meropenem (carbapenem). Adjusted based on susceptibility.
Prevalence:
How common the health condition is within a specific population.
Rare; higher in healthcare-associated settings.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Neurosurgery, trauma, immunosuppression, systemic staphylococcal infections.
Prognosis:
The expected outcome or course of the condition over time.
Good with early treatment; poor in untreated or advanced cases.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Brain abscesses, hearing loss, neurological deficits, septic shock.
Subdural Empyema
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
fever; severe headache; nausea; altered mental status; focal neurological deficits; seizures
Root Cause:
Collection of pus between the dura mater and arachnoid membrane, often caused by bacterial infection spreading from sinuses or middle ear.
How it's Diagnosed: videos
MRI with contrast; CT scan; blood cultures.
Treatment:
Surgical drainage combined with antibiotic therapy.
Medications:
Broad-spectrum antibiotics, such as vancomycin (glycopeptide) with ceftriaxone (cephalosporin) or metronidazole (nitroimidazole class) for anaerobic coverage.
Prevalence:
How common the health condition is within a specific population.
Rare; more common in males and children with sinus infections.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Sinusitis, otitis media, skull trauma, neurosurgery.
Prognosis:
The expected outcome or course of the condition over time.
Good with timely intervention; delayed treatment increases risk of mortality and morbidity.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Brain abscess, cerebral venous thrombosis, neurological deficits, sepsis.
Tetanus
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
muscle stiffness; lockjaw (trismus); painful muscle spasms; difficulty swallowing; fever; sweating
Root Cause:
Caused by Clostridium tetani bacteria, which release tetanospasmin, a toxin that interferes with motor neuron signaling, leading to muscle rigidity and spasms.
How it's Diagnosed: videos
Based on clinical symptoms and history of injury; no definitive lab test but may include wound culture for C. tetani.
Treatment:
Wound care, administration of tetanus immunoglobulin (TIG), supportive care (e.g., muscle relaxants, ventilatory support if needed), and antibiotics.
Medications:
Penicillin G or metronidazole (antibiotics to eradicate C. tetani), diazepam or baclofen (muscle relaxants to control spasms).
Prevalence:
How common the health condition is within a specific population.
Rare in developed countries due to vaccination; most cases occur in unvaccinated individuals or in areas with poor healthcare access.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Unvaccinated status, puncture wounds, animal bites, burns, or other injuries contaminated with soil or feces.
Prognosis:
The expected outcome or course of the condition over time.
Can be life-threatening if untreated; with appropriate care, survival is high, but recovery may take weeks to months.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Respiratory failure, fractures from severe spasms, autonomic dysfunction, secondary infections, and death if untreated.
Tropical Myeloneuropathies
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
progressive weakness; spastic paralysis; gait abnormalities; sensory disturbances; urinary incontinence
Root Cause:
Often linked to dietary deficiencies (e.g., vitamin B12) or infections (e.g., HTLV-1 virus), leading to spinal cord or nerve damage.
How it's Diagnosed: videos
Clinical examination, blood tests (e.g., for vitamin deficiencies or HTLV-1 serology), MRI, and nerve conduction studies.
Treatment:
Address underlying causes, nutritional supplementation, antiviral therapy if HTLV-1 related, and physical rehabilitation.
Medications:
Antiretroviral agents for HTLV-1 (e.g., zidovudine ); vitamin B12 or folic acid supplements if deficiency is present.
Prevalence:
How common the health condition is within a specific population.
Rare, primarily found in tropical and subtropical regions.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Malnutrition, exposure to HTLV-1, genetic predisposition, and environmental factors.
Prognosis:
The expected outcome or course of the condition over time.
Variable; can be managed with early intervention but may lead to chronic disability in severe cases.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic disability, loss of mobility, and secondary infections.
Tuberculous Meningitis
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
headache; fever; nausea; vomiting; stiff neck; altered mental status; seizures
Root Cause:
Infection of the meninges by Mycobacterium tuberculosis, leading to inflammation and increased intracranial pressure.
How it's Diagnosed: videos
Lumbar puncture with CSF analysis (increased protein, low glucose, and lymphocytic predominance), imaging (MRI or CT), and microbiological tests for M. tuberculosis.
Treatment:
Long-term combination antitubercular therapy (e.g., isoniazid, rifampin, pyrazinamide, ethambutol), corticosteroids to reduce inflammation, and supportive care.
Medications:
First-line antitubercular drugs (e.g., isoniazid , rifampin ); corticosteroids (e.g., dexamethasone ) to manage inflammation.
Prevalence:
How common the health condition is within a specific population.
More common in areas with high TB burden; rare in developed countries.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
HIV infection, immunosuppression, close contact with TB patients, malnutrition.
Prognosis:
The expected outcome or course of the condition over time.
With early treatment, survival is possible, but delayed therapy can result in high morbidity and mortality.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Hydrocephalus, stroke, cranial nerve palsies, cognitive deficits, and death if untreated.
Venezuelan Equine Encephalitis
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
fever; headache; nausea; vomiting; seizures; confusion; weakness; photophobia
Root Cause:
Caused by the Venezuelan equine encephalitis virus, transmitted by mosquitoes, leading to inflammation of the brain.
How it's Diagnosed: videos
Serologic tests for viral antibodies (e.g., ELISA), PCR for viral RNA, and CSF analysis.
Treatment:
Supportive care (e.g., hydration, antipyretics, and seizure control); no specific antiviral treatment available.
Medications:
Antipyretics (e.g., acetaminophen for fever); anticonvulsants (e.g., phenytoin or valproic acid for seizures).
Prevalence:
How common the health condition is within a specific population.
Sporadic outbreaks in Central and South America; rare in humans, more common in equines.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Living or working in endemic areas, exposure to mosquitoes, and outdoor activities.
Prognosis:
The expected outcome or course of the condition over time.
Most recover fully, but severe cases may lead to neurological deficits or death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Long-term neurological sequelae (e.g., cognitive deficits, epilepsy), and in severe cases, death.
Viral Encephalitis
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
fever; headache; confusion; seizures; nausea; vomiting; altered mental status; photophobia
Root Cause:
Brain inflammation caused by viral infections (e.g., herpes simplex virus, arboviruses), leading to neuronal damage.
How it's Diagnosed: videos
Clinical evaluation, CSF analysis, PCR for viral DNA/RNA, and neuroimaging (e.g., MRI).
Treatment:
Antiviral therapy for specific viruses (e.g., acyclovir for herpes simplex virus); supportive care for other viral causes.
Medications:
Acyclovir (for herpes simplex); antipyretics (e.g., ibuprofen for fever); anticonvulsants (e.g., levetiracetam for seizures).
Prevalence:
How common the health condition is within a specific population.
Varies; common in areas with high mosquito-borne virus activity or sporadic herpes outbreaks.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Immunosuppression, unvaccinated status, and mosquito exposure.
Prognosis:
The expected outcome or course of the condition over time.
Depends on the cause and severity; early treatment improves outcomes, but severe cases may result in lasting deficits.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Long-term neurological damage, seizures, cognitive deficits, and death if untreated.
Viral Meningitis
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
headache; fever; neck stiffness; photophobia; nausea; vomiting
Root Cause:
Inflammation of the meninges caused by viral infections (e.g., enteroviruses, herpesviruses), leading to non-purulent inflammation.
How it's Diagnosed: videos
CSF analysis (increased lymphocytes, normal glucose, elevated protein), PCR for viral pathogens.
Treatment:
Supportive care (hydration, pain relief, antipyretics); antiviral therapy for specific causes (e.g., herpesvirus).
Medications:
Acyclovir (for herpes-related cases); over-the-counter analgesics (e.g., acetaminophen for headache and fever).
Prevalence:
How common the health condition is within a specific population.
Common; most cases are mild and self-limiting.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Exposure to infected individuals, immunosuppression, and travel to endemic regions.
Prognosis:
The expected outcome or course of the condition over time.
Excellent in most cases; severe outcomes are rare.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Rare; may include chronic headaches or recurrent symptoms.
West Nile Virus (WNV) Infection and Encephalitis (WNE)
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
fever; headache; muscle weakness; fatigue; seizures; confusion; stiff neck
Root Cause:
Viral infection transmitted by mosquitoes, leading to inflammation of the brain and nervous system.
How it's Diagnosed: videos
PCR or serology for WNV in blood or CSF; neuroimaging may reveal inflammation.
Treatment:
Supportive care (hydration, pain management, seizure control); no specific antiviral therapy.
Medications:
Analgesics for pain relief (e.g., acetaminophen ); anticonvulsants (e.g., levetiracetam for seizures).
Prevalence:
How common the health condition is within a specific population.
Found in many parts of the world, especially during mosquito season.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Outdoor activities, lack of mosquito control, immunosuppression.
Prognosis:
The expected outcome or course of the condition over time.
Most recover, but severe cases may result in neurological deficits or death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic fatigue, cognitive impairment, and long-term neurological deficits in severe cases.
Western Equine Encephalitis (WEE)
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
fever; headache; nausea; vomiting; seizures; altered mental status; muscle weakness
Root Cause:
Caused by the Western equine encephalitis virus, transmitted by mosquitoes, leading to inflammation of the brain and central nervous system.
How it's Diagnosed: videos
Serologic testing for viral antibodies (e.g., IgM ELISA), PCR for viral RNA, and CSF analysis.
Treatment:
Supportive care (e.g., intravenous fluids, fever control, seizure management); no specific antiviral therapy available.
Medications:
Antipyretics (e.g., ibuprofen for fever and discomfort); anticonvulsants (e.g., diazepam or levetiracetam for seizure control).
Prevalence:
How common the health condition is within a specific population.
Rare; found in North and South America, with sporadic outbreaks in rural areas.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Exposure to mosquitoes in endemic regions, outdoor activities, and lack of mosquito control.
Prognosis:
The expected outcome or course of the condition over time.
Most cases are mild and resolve without long-term effects; severe cases can lead to neurological deficits or death, particularly in children and the elderly.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Long-term neurological deficits (e.g., cognitive impairment, motor dysfunction), seizures, and death in severe cases.
Infective Endocarditis
Specialty: Infectious Diseases
Category: Cardiovascular and Intravascular Infections
Symptoms:
fever; heart murmur; fatigue; anemia; hematuria; petechiae; osler's nodes; janeway lesions; splinter hemorrhages
Root Cause:
Bacterial or fungal infection of the heart valves or endocardium, often due to bacteremia from dental procedures, intravenous drug use, or indwelling devices.
How it's Diagnosed: videos
Diagnosed via blood cultures and echocardiography.
Treatment:
Treated with prolonged intravenous antibiotics and, if needed, surgical valve repair or replacement.
Medications:
Antibiotics like penicillin, ceftriaxone , vancomycin (specific to pathogen sensitivity). Antifungal agents (e.g., amphotericin B) if fungal endocarditis is diagnosed.
Prevalence:
How common the health condition is within a specific population.
Approximately 3-10 cases per 100,000 people annually in developed countries.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Prosthetic heart valves, congenital heart defects, intravenous drug use, indwelling catheters, recent invasive procedures.
Prognosis:
The expected outcome or course of the condition over time.
Early treatment reduces mortality to 15-20%; untreated cases have mortality exceeding 50%.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Heart failure, embolic events, stroke, abscess formation, and persistent infection.
Myocardial Abscess
Specialty: Infectious Diseases
Category: Cardiovascular and Intravascular Infections
Symptoms:
chest pain; fever; heart murmur; dyspnea; tachycardia; systemic signs of sepsis
Root Cause:
Focal collection of pus within myocardial tissue due to bacterial or fungal infection, often secondary to infective endocarditis.
How it's Diagnosed: videos
Diagnosed with imaging (e.g., echocardiography, MRI) and blood cultures.
Treatment:
Treated with intravenous antibiotics and surgical drainage if necessary.
Medications:
Antibiotics such as vancomycin , ceftriaxone , or antifungals (e.g., amphotericin B for fungal infections).
Prevalence:
How common the health condition is within a specific population.
Rare; occurs as a complication of infective endocarditis in 1-2% of cases.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Intravenous drug use, immunocompromised states, prosthetic valves, delayed treatment of infective endocarditis.
Prognosis:
The expected outcome or course of the condition over time.
Poor without surgical intervention; survival improves significantly with timely treatment.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Septicemia, rupture into cardiac chambers, valvular dysfunction, or embolic events.
Rheumatic Fever
Specialty: Infectious Diseases
Category: Cardiovascular and Intravascular Infections
Symptoms:
fever; joint pain and swelling; red or hot joints; heart murmur; skin rash (erythema marginatum); sydenham's chorea; subcutaneous nodules
Root Cause:
Autoimmune reaction to untreated group A Streptococcus infection (e.g., strep throat), leading to systemic inflammation affecting the heart, joints, skin, and nervous system.
How it's Diagnosed: videos
Diagnosed clinically using the Jones criteria.
Treatment:
Treated with penicillin for Group A streptococcus, anti-inflammatory medications (e.g., aspirin), and prophylactic antibiotics to prevent recurrence.
Medications:
Penicillin (antibiotic) for infection. Aspirin or naproxen (NSAIDs) for inflammation. Prednisone (corticosteroid) for severe carditis.
Prevalence:
How common the health condition is within a specific population.
Rare in developed countries due to widespread use of antibiotics; more common in resource-limited settings.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Untreated strep throat, overcrowded living conditions, family history.
Prognosis:
The expected outcome or course of the condition over time.
Good with prompt treatment; untreated cases can lead to chronic rheumatic heart disease.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic valvular heart disease, heart failure, atrial fibrillation, stroke.
Candidiasis
Specialty: Infectious Diseases
Category: Fungal Infections
Symptoms:
white patches in the mouth or throat; vaginal itching; discomfort during urination; skin rashes; fatigue; fever in systemic cases
Root Cause:
Overgrowth of Candida species, most commonly Candida albicans, in various body parts due to disrupted microbiota or weakened immunity.
How it's Diagnosed: videos
Clinical examination, culture of affected site, blood tests for systemic candidiasis, and PCR testing.
Treatment:
Antifungal medications applied topically, orally, or intravenously depending on the site and severity.
Medications:
Fluconazole (antifungal triazole), Clotrimazole (topical antifungal), Amphotericin B (antifungal polyene), and Echinocandins like Caspofungin for invasive infections.
Prevalence:
How common the health condition is within a specific population.
Common in individuals with diabetes, on antibiotics, or immunosuppressed. Vaginal candidiasis affects 70-75% of women at least once in their lifetime.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Immunosuppression, recent antibiotic use, diabetes, prolonged use of corticosteroids, and use of invasive devices like catheters.
Prognosis:
The expected outcome or course of the condition over time.
Excellent for localized infections; systemic candidiasis requires aggressive treatment but can have high mortality rates.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Esophagitis, disseminated candidiasis, endocarditis, or septic shock in severe cases.
Chromoblastomycosis
Specialty: Infectious Diseases
Category: Fungal Infections
Sub-category: Subcutaneous Mycoses
Symptoms:
wart-like lesions; ulcerated plaques; skin nodules; itching; secondary bacterial infections
Root Cause:
Chronic fungal infection caused by melanized fungi (e.g., Fonsecaea or Cladophialophora species) entering through skin trauma.
How it's Diagnosed: videos
Clinical examination, biopsy with histopathology showing muriform cells, fungal cultures, and PCR-based methods.
Treatment:
Long-term antifungal therapy combined with surgical excision or cryotherapy for localized lesions.
Medications:
Itraconazole and terbinafine (antifungal agents inhibiting fungal growth). Amphotericin B may be used in severe cases.
Prevalence:
How common the health condition is within a specific population.
Rare, endemic in tropical and subtropical regions, with higher incidence in rural agricultural workers.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Skin trauma, barefoot walking in endemic areas, and immunosuppression.
Prognosis:
The expected outcome or course of the condition over time.
Good with early treatment, though chronic cases may require prolonged therapy. Without treatment, progression can lead to disfigurement.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic infections, secondary bacterial infections, and squamous cell carcinoma in long-standing lesions.
Coccidioidomycosis and Valley Fever
Specialty: Infectious Diseases
Category: Fungal Infections
Sub-category: Endemic Mycoses
Symptoms:
fever; cough; chest pain; fatigue; headache; rash; joint pain
Root Cause:
Infection caused by Coccidioides species (C. immitis or C. posadasii) through inhalation of fungal spores, leading to localized or disseminated disease.
How it's Diagnosed: videos
Serologic testing (IgM and IgG antibodies), fungal cultures, histopathology, or PCR-based diagnostics.
Treatment:
Mild cases may resolve without treatment; moderate to severe cases require antifungal therapy, such as azoles or amphotericin B.
Medications:
Fluconazole or itraconazole for most cases. Amphotericin B is used for severe or disseminated disease. These drugs are systemic antifungal agents targeting fungal growth or membrane integrity.
Prevalence:
How common the health condition is within a specific population.
Endemic in the southwestern U.S., northern Mexico, and parts of Central and South America; incidence rates vary but are increasing with climate change.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Residing or working in endemic areas, soil disturbance, immunosuppression, and pregnancy (third trimester).
Prognosis:
The expected outcome or course of the condition over time.
Most cases are self-limited; severe or disseminated cases have variable outcomes, with mortality up to 30% in untreated disseminated infections.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Dissemination to skin, bones, or meninges; chronic pulmonary disease; and meningitis.
Cryptococcosis
Specialty: Infectious Diseases
Category: Fungal Infections
Sub-category: Opportunistic Mycoses
Symptoms:
fever; headache; nausea; vomiting; altered mental status; neck stiffness in meningitis; cough; chest pain
Root Cause:
Infection by Cryptococcus neoformans or Cryptococcus gattii, typically through inhalation of spores, often affecting immunocompromised individuals.
How it's Diagnosed: videos
India ink staining, cryptococcal antigen testing, fungal cultures, or molecular diagnostics.
Treatment:
Induction therapy with amphotericin B and flucytosine, followed by maintenance therapy with fluconazole.
Medications:
Amphotericin B (polyenes), flucytosine (antifungal antimetabolite), and fluconazole (azole antifungal). These target fungal membranes or DNA synthesis.
Prevalence:
How common the health condition is within a specific population.
Common opportunistic infection in HIV/AIDS patients, with significant global burden in low-resource settings.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
HIV/AIDS, organ transplantation, corticosteroid use, and other immunosuppressive conditions.
Prognosis:
The expected outcome or course of the condition over time.
Early treatment significantly improves outcomes, though CNS involvement can lead to high mortality (up to 70% in severe untreated cases).
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Cryptococcal meningitis, hydrocephalus, vision loss, and neurological deficits.
Cutaneous Cryptococcus
Specialty: Infectious Diseases
Category: Fungal Infections
Sub-category: Opportunistic Mycoses
Symptoms:
skin lesions ranging from papules to ulcers; nodules; plaques; secondary bacterial infections
Root Cause:
Localized or disseminated infection with Cryptococcus neoformans or Cryptococcus gattii involving the skin, often in immunocompromised patients.
How it's Diagnosed: videos
Skin biopsy, fungal cultures, or antigen testing.
Treatment:
Antifungal therapy (similar to systemic cryptococcosis); surgical excision in some localized cases.
Medications:
Amphotericin B, flucytosine , and fluconazole as per systemic cryptococcosis guidelines.
Prevalence:
How common the health condition is within a specific population.
Less common than systemic cryptococcosis; often associated with disseminated disease in immunosuppressed individuals.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Immunosuppression, HIV/AIDS, and direct fungal exposure in endemic areas.
Prognosis:
The expected outcome or course of the condition over time.
Favorable for isolated cutaneous lesions; prognosis depends on systemic involvement and immune status.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Progression to systemic infection, particularly in untreated or immunocompromised patients.
Fungal Endophthalmitis
Specialty: Infectious Diseases
Category: Fungal Infections
Sub-category: Ocular Mycoses
Symptoms:
eye pain; decreased vision; redness; floaters; photophobia; swelling
Root Cause:
Infection of the intraocular structures by fungi, commonly Candida species or filamentous fungi following surgery, trauma, or systemic dissemination.
How it's Diagnosed: videos
Clinical examination, vitreous or aqueous fluid sampling, fungal cultures, and PCR.
Treatment:
Intravitreal or systemic antifungals, with or without vitrectomy.
Medications:
Amphotericin B (intravitreal ), voriconazole , or fluconazole for systemic infections. These drugs inhibit fungal growth or disrupt fungal membranes.
Prevalence:
How common the health condition is within a specific population.
Rare; often occurs as a complication of intraocular surgery or systemic candidiasis.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Ocular surgery, trauma, IV drug use, and systemic fungal infections.
Prognosis:
The expected outcome or course of the condition over time.
Early treatment can preserve vision, but prognosis is poor for delayed cases.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Vision loss, glaucoma, and retinal detachment.
Fungal Keratitis
Specialty: Infectious Diseases
Category: Fungal Infections
Sub-category: Ocular Mycoses
Symptoms:
eye pain; redness; blurred vision; photophobia; tearing; discharge
Root Cause:
Infection of the cornea by fungi, commonly Fusarium, Aspergillus, or Candida species, often following trauma or use of contact lenses.
How it's Diagnosed: videos
Corneal scraping with microscopy, fungal cultures, and molecular diagnostics.
Treatment:
Topical antifungal therapy; surgical interventions like debridement or keratoplasty in severe cases.
Medications:
Natamycin (topical polyene antifungal), voriconazole (topical or systemic), or amphotericin B in severe cases.
Prevalence:
How common the health condition is within a specific population.
More common in tropical and subtropical regions; associated with agricultural injuries and contact lens use.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Corneal trauma, contact lens wear, steroid use, and tropical climates.
Prognosis:
The expected outcome or course of the condition over time.
Good with early treatment, though advanced cases may result in corneal scarring or vision loss.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Corneal perforation, endophthalmitis, and vision impairment.
Majocchi Granuloma
Specialty: Infectious Diseases
Category: Fungal Infections
Symptoms:
red or scaly patches; swelling or nodules in the skin; itchiness; pain in affected areas
Root Cause:
Fungal infection caused by dermatophytes invading deeper skin layers, often associated with trauma or immunosuppression.
How it's Diagnosed: videos
Clinical examination, fungal culture, skin biopsy, and histopathology.
Treatment:
Systemic antifungal therapy combined with topical treatments.
Medications:
Oral terbinafine (allylamine antifungal) or itraconazole (triazole antifungal). Topical antifungal creams such as clotrimazole (imidazole antifungal) may also be used.
Prevalence:
How common the health condition is within a specific population.
Rare; seen more frequently in immunocompromised individuals or those with repeated skin trauma.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Trauma to the skin, immunosuppression, chronic steroid use.
Prognosis:
The expected outcome or course of the condition over time.
Good with appropriate antifungal therapy, but recurrence is possible if underlying conditions persist.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Persistent infection, scarring, and secondary bacterial infections.
Mucormycosis (Zygomycosis)
Specialty: Infectious Diseases
Category: Fungal Infections
Symptoms:
facial pain or swelling; black or necrotic tissue in nasal passages; fever; headache; vision changes; sinus congestion or discharge
Root Cause:
Aggressive fungal infection caused by Mucorales species, often associated with compromised immune function or poorly controlled diabetes.
How it's Diagnosed: videos
Histopathology, fungal culture, and imaging studies (CT or MRI).
Treatment:
Aggressive surgical debridement and systemic antifungal therapy.
Medications:
Amphotericin B (polyene antifungal) as the first-line treatment, followed by posaconazole or isavuconazole (triazole antifungals) for maintenance therapy.
Prevalence:
How common the health condition is within a specific population.
Rare; more common in immunocompromised individuals or those with uncontrolled diabetes or post-COVID-19 complications.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Diabetes, immunosuppression, organ transplant, iron overload, prolonged corticosteroid use.
Prognosis:
The expected outcome or course of the condition over time.
Poor if not treated early; mortality rates are high due to rapid progression and complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Orbital cellulitis, cavernous sinus thrombosis, intracranial involvement, systemic fungal dissemination.
Paracoccidioidomycosis
Specialty: Infectious Diseases
Category: Fungal Infections
Symptoms:
fever; weight loss; chronic cough; skin lesions; oral ulcers; lymphadenopathy; difficulty breathing
Root Cause:
Caused by inhalation of spores from Paracoccidioides brasiliensis or Paracoccidioides lutzii, leading to systemic fungal infection.
How it's Diagnosed: videos
Microscopic examination of sputum or tissue biopsies, fungal culture, serologic tests (e.g., immunodiffusion), and imaging studies (e.g., chest X-ray or CT).
Treatment:
Long-term antifungal therapy, typically lasting several months.
Medications:
Azole antifungals like itraconazole (first-line treatment) or amphotericin B for severe cases. Itraconazole is a triazole antifungal; amphotericin B is a polyene antifungal.
Prevalence:
How common the health condition is within a specific population.
Endemic to South and Central America, particularly in rural areas; incidence varies but is most common in agricultural workers.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Male gender, rural occupation, environmental exposure to soil, weakened immune system.
Prognosis:
The expected outcome or course of the condition over time.
Good with early diagnosis and treatment, but untreated cases can be fatal.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Pulmonary fibrosis, chronic lung disease, adrenal insufficiency, and systemic dissemination.
Pneumocystis Jiroveci Pneumonia (PJP)
Specialty: Infectious Diseases
Category: Fungal Infections
Symptoms:
fever; dry cough; shortness of breath; fatigue; chest pain; hypoxia
Root Cause:
Opportunistic fungal infection caused by Pneumocystis jiroveci, primarily affecting immunocompromised individuals.
How it's Diagnosed: videos
Microscopic identification of Pneumocystis jiroveci in respiratory samples (e.g., sputum, bronchoalveolar lavage); PCR and beta-D-glucan assays; chest X-rays or CT scans.
Treatment:
Antifungal therapy with adjunctive corticosteroids in severe cases to reduce inflammation.
Medications:
Trimethoprim-sulfamethoxazole (TMP-SMX) is the first-line treatment. Alternatives include pentamidine , atovaquone , or clindamycin with primaquine . TMP-SMX is an antibiotic with antifungal properties; pentamidine is an antiprotozoal and antifungal agent.
Prevalence:
How common the health condition is within a specific population.
Common among HIV/AIDS patients and other immunosuppressed populations; incidence decreases with antiretroviral therapy (ART).
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
HIV/AIDS, organ transplantation, cancer chemotherapy, chronic corticosteroid use.
Prognosis:
The expected outcome or course of the condition over time.
High mortality if untreated but generally good with early treatment.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Respiratory failure, pneumothorax, acute respiratory distress syndrome (ARDS), and systemic infections.
Sporotrichosis
Specialty: Infectious Diseases
Category: Fungal Infections
Symptoms:
painless skin nodules; ulcerative lesions; lymphangitis; swelling at infection site
Root Cause:
Infection with Sporothrix schenckii complex through skin inoculation, leading to cutaneous or lymphocutaneous disease.
How it's Diagnosed: videos
Fungal culture of tissue or pus, histopathology, and PCR testing.
Treatment:
Long-term antifungal therapy, usually several months.
Medications:
Itraconazole is the first-line treatment for most cases. For disseminated or severe infections, amphotericin B may be used. Potassium iodide is an alternative for cutaneous forms. Itraconazole is a triazole antifungal; amphotericin B is a polyene antifungal.
Prevalence:
How common the health condition is within a specific population.
Common in tropical and subtropical regions, particularly in individuals handling soil, plants, or decaying vegetation.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Gardeners, agricultural workers, and those with skin injuries.
Prognosis:
The expected outcome or course of the condition over time.
Excellent for cutaneous forms with treatment; disseminated forms have a poorer prognosis.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Osteoarticular involvement, systemic dissemination, and chronic lesions.
Trichosporon Infections
Specialty: Infectious Diseases
Category: Fungal Infections
Symptoms:
fever; sepsis-like syndrome; skin lesions; organ dysfunction in severe cases
Root Cause:
Opportunistic infection caused by Trichosporon species, often in immunocompromised hosts.
How it's Diagnosed: videos
Blood cultures, fungal cultures from infected tissues, and molecular identification (e.g., PCR).
Treatment:
Antifungal therapy tailored to susceptibility testing.
Medications:
Azoles like voriconazole or fluconazole are preferred. Amphotericin B can be used in resistant cases. Voriconazole is a triazole antifungal; amphotericin B is a polyene antifungal.
Prevalence:
How common the health condition is within a specific population.
Rare but increasing in immunosuppressed populations; nosocomial outbreaks have been reported.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Hematologic malignancies, neutropenia, broad-spectrum antibiotic use, indwelling catheters.
Prognosis:
The expected outcome or course of the condition over time.
Variable; high mortality in disseminated infections despite treatment.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Disseminated infection, septic shock, and organ failure.
Amebic Liver/Hepatic Abscesses
Specialty: Infectious Diseases
Category: Gastrointestinal Tract and Intra-abdominal Infections
Symptoms:
fever; right upper quadrant abdominal pain; hepatomegaly; jaundice; weight loss; night sweats
Root Cause:
Liver abscess formation due to Entamoeba histolytica infection, typically contracted via contaminated food or water.
How it's Diagnosed: videos
Serologic tests for antibodies, imaging (ultrasound or CT showing hypoechoic lesions in the liver), and stool tests for E. histolytica.
Treatment:
Antimicrobial therapy and, in some cases, drainage of abscesses. Avoid invasive procedures unless necessary.
Medications:
Metronidazole or tinidazole (antiprotozoal agents) to treat the infection, followed by luminal agents like paromomycin to eradicate intestinal colonization.
Prevalence:
How common the health condition is within a specific population.
Common in endemic regions like South and Central America, Africa, and Asia, with an estimated global prevalence of up to 50 million cases annually.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Travel to endemic regions, poor sanitation, immunosuppression, and male gender.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with timely treatment; untreated cases can lead to rupture and high mortality.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Rupture into pleural or peritoneal spaces, secondary bacterial infections, and sepsis.
Bacterial Gastroenteritis
Specialty: Infectious Diseases
Category: Gastrointestinal Tract and Intra-abdominal Infections
Symptoms:
diarrhea (often watery or bloody); abdominal cramps; fever; nausea; vomiting; dehydration
Root Cause:
Infection of the gastrointestinal tract caused by pathogenic bacteria like Salmonella, Shigella, Escherichia coli, or Campylobacter.
How it's Diagnosed: videos
Stool cultures, stool antigen tests, and molecular testing (PCR) to identify bacterial pathogens; clinical history of recent travel or food exposure.
Treatment:
Rehydration therapy (oral or intravenous), dietary adjustments, and in severe cases, antibiotics depending on the pathogen.
Medications:
Antibiotics like ciprofloxacin (fluoroquinolone) or azithromycin (macrolide) are used for severe infections. Oral rehydration solutions (ORS) and zinc supplementation help manage dehydration.
Prevalence:
How common the health condition is within a specific population.
A common cause of morbidity worldwide, particularly in low-resource settings; affects millions annually, especially children under five.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Contaminated food or water, poor hygiene, travel to endemic areas, and immunocompromised states.
Prognosis:
The expected outcome or course of the condition over time.
Usually self-limiting; severe cases may lead to complications without prompt treatment.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Severe dehydration, hemolytic uremic syndrome (HUS), and reactive arthritis.
Bacterial Overgrowth Syndrome
Specialty: Infectious Diseases
Category: Gastrointestinal Tract and Intra-abdominal Infections
Symptoms:
abdominal bloating; diarrhea; malabsorption; weight loss; fatigue; nausea
Root Cause:
Excessive growth of bacteria in the small intestine causing nutrient malabsorption and gastrointestinal symptoms.
How it's Diagnosed: videos
Breath tests (hydrogen or methane), small bowel aspirate and culture, and clinical response to treatment.
Treatment:
Addressing underlying causes, dietary modifications, and antibiotics to reduce bacterial load.
Medications:
Rifaximin (broad-spectrum non-absorbable antibiotic), metronidazole (antimicrobial), and probiotics to restore gut flora balance.
Prevalence:
How common the health condition is within a specific population.
Exact prevalence is uncertain; common in conditions causing motility disorders or structural abnormalities of the GI tract.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Chronic gastrointestinal diseases (e.g., irritable bowel syndrome, Crohn’s disease), previous surgeries (e.g., gastric bypass), and use of proton pump inhibitors.
Prognosis:
The expected outcome or course of the condition over time.
Good with appropriate treatment; symptoms often resolve but recurrence is possible.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic malnutrition, vitamin deficiencies (B12, fat-soluble vitamins), and increased intestinal permeability.
Cholangitis
Specialty: Infectious Diseases
Category: Gastrointestinal Tract and Intra-abdominal Infections
Symptoms:
fever; jaundice; right upper quadrant pain; chills; hypotension (in severe cases); mental confusion
Root Cause:
Infection and inflammation of the bile ducts, often caused by obstruction (e.g., gallstones or strictures) leading to bacterial overgrowth.
How it's Diagnosed: videos
Clinical presentation (Charcot’s triad), liver function tests, blood cultures, and imaging (ultrasound, CT, or MRCP) to identify obstruction or infection.
Treatment:
Broad-spectrum antibiotics, biliary drainage (ERCP or percutaneous), and supportive care.
Medications:
Antibiotics like piperacillin-tazobactam (broad-spectrum beta-lactam), meropenem (carbapenem), or ciprofloxacin (fluoroquinolone) combined with metronidazole (anaerobic coverage).
Prevalence:
How common the health condition is within a specific population.
More common in adults with biliary tract disease; prevalence increases with age and risk factors.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Gallstones, bile duct strictures, previous biliary surgeries, ERCP, or malignancies of the biliary system.
Prognosis:
The expected outcome or course of the condition over time.
Good with timely treatment; untreated cases can progress to sepsis and organ failure.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Biliary sepsis, abscess formation, acute pancreatitis, and chronic liver damage.
Clostridioides (Clostridium) Difficile Colitis
Specialty: Infectious Diseases
Category: Gastrointestinal Tract and Intra-abdominal Infections
Symptoms:
watery diarrhea; abdominal pain; fever; nausea; loss of appetite; dehydration; foul-smelling stool
Root Cause:
Infection caused by Clostridioides difficile bacteria, leading to an overgrowth in the colon often triggered by antibiotic use that disrupts normal gut flora.
How it's Diagnosed: videos
Stool tests for C. difficile toxins or genetic material (PCR), colonoscopy to identify pseudomembranous colitis, and imaging (e.g., CT scan) in severe cases.
Treatment:
Discontinuation of the inciting antibiotic, initiation of specific antibiotics to target C. difficile, and, in severe cases, fecal microbiota transplantation (FMT).
Medications:
Vancomycin (oral, first-line treatment for severe cases, classified as glycopeptide antibiotics), Fidaxomicin (narrow-spectrum antibiotic targeting C. difficile), and Metronidazole (alternative treatment for mild to moderate cases, classified as a nitroimidazole antibiotic).
Prevalence:
How common the health condition is within a specific population.
Affects about 500,000 people annually in the U.S.; more common in hospitalized or recently discharged patients.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Recent antibiotic use, advanced age, hospitalization, weakened immune system, gastrointestinal surgery, proton pump inhibitor use.
Prognosis:
The expected outcome or course of the condition over time.
Good with appropriate treatment; however, recurrence occurs in approximately 20–25% of patients.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Severe dehydration, toxic megacolon, bowel perforation, sepsis, and death in extreme cases.
Cyclospora Infection (Cyclosporiasis)
Specialty: Infectious Diseases
Category: Gastrointestinal Tract and Intra-abdominal Infections
Symptoms:
watery diarrhea; loss of appetite; weight loss; cramping; bloating; gas; fatigue; nausea; low-grade fever
Root Cause:
Protozoan parasite Cyclospora cayetanensis infects the small intestine, often transmitted via contaminated food or water.
How it's Diagnosed: videos
Stool examination for Cyclospora oocysts, using microscopy with special stains or molecular techniques like PCR.
Treatment:
Antiparasitic therapy, rehydration, and electrolyte replacement.
Medications:
Trimethoprim-sulfamethoxazole (TMP-SMX, classified as a combination antibiotic) is the primary treatment. No alternative medications are well-established for sulfa-allergic patients.
Prevalence:
How common the health condition is within a specific population.
Sporadic outbreaks in the U.S. often linked to imported fresh produce; endemic in tropical and subtropical regions.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Consumption of contaminated food or water, international travel, and weakened immune systems.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with treatment; without treatment, symptoms may persist for weeks.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Severe dehydration and malabsorption in prolonged or untreated cases.
Hepatitis A
Specialty: Infectious Diseases
Category: Liver Infections
Sub-category: Acute Viral Hepatitis
Symptoms:
fatigue; nausea; vomiting; abdominal pain; jaundice; dark urine; pale stools; fever
Root Cause:
Infection with the Hepatitis A virus (HAV) causing inflammation of the liver; spread primarily through contaminated food and water.
How it's Diagnosed: videos
Blood tests detecting HAV-specific IgM antibodies, liver function tests.
Treatment:
Primarily supportive care (rest, hydration, avoiding alcohol); no specific antiviral therapy.
Medications:
No antiviral medications; symptomatic relief with antipyretics (e.g., acetaminophen for fever) or antiemetics for nausea.
Prevalence:
How common the health condition is within a specific population.
Common in areas with poor sanitation; estimated 1.4 million cases worldwide annually.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Travel to endemic regions, consuming contaminated food or water, close contact with an infected person.
Prognosis:
The expected outcome or course of the condition over time.
Full recovery in most cases within weeks to months; no chronic infection.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Rare, but can include fulminant hepatitis in older adults or those with pre-existing liver conditions.
Hepatitis B
Specialty: Infectious Diseases
Category: Liver Infections
Sub-category: Chronic Viral Hepatitis
Symptoms:
fatigue; loss of appetite; nausea; jaundice; dark urine; joint pain; abdominal pain
Root Cause:
Infection with the Hepatitis B virus (HBV), which can cause both acute and chronic liver inflammation, leading to liver damage.
How it's Diagnosed: videos
Blood tests for HBsAg (surface antigen), anti-HBc antibodies, and HBV DNA; liver function tests.
Treatment:
Treated with antiviral medications such as tenofovir or entecavir to suppress viral replication, alongside interferon therapy in select cases, and supportive care, with monitoring for liver function and complications.
Medications:
Nucleos(t)ide analogs (e.g., entecavir , tenofovir ) to inhibit viral replication. Interferon-alpha injections to boost the immune response.
Prevalence:
How common the health condition is within a specific population.
Affects over 296 million people worldwide; common in Asia and Africa.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Unprotected sex, needle-sharing, perinatal transmission, healthcare worker exposure.
Prognosis:
The expected outcome or course of the condition over time.
Acute cases often resolve; chronic cases may progress to cirrhosis or liver cancer without treatment.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Liver cirrhosis, hepatocellular carcinoma, liver failure.
Hepatitis C
Specialty: Infectious Diseases
Category: Liver Infections
Sub-category: Chronic Viral Hepatitis
Symptoms:
fatigue; nausea; loss of appetite; jaundice; dark urine; joint pain; abdominal pain
Root Cause:
Infection with the Hepatitis C virus (HCV), often leading to chronic liver inflammation and scarring.
How it's Diagnosed: videos
Blood tests for anti-HCV antibodies and HCV RNA, liver function tests.
Treatment:
Direct-acting antivirals (DAAs) to cure the infection.
Medications:
DAAs (e.g., sofosbuvir , ledipasvir , velpatasvir ) targeting viral proteins for replication. Ribavirin (in combination in certain cases).
Prevalence:
How common the health condition is within a specific population.
Affects over 58 million people worldwide; common in intravenous drug users.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Needle-sharing, blood transfusions (before 1992), healthcare exposure, tattoos or piercings with unsterilized equipment.
Prognosis:
The expected outcome or course of the condition over time.
Highly curable with DAAs in 8–12 weeks; untreated, it may progress to cirrhosis or liver cancer.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Liver cirrhosis, hepatocellular carcinoma, portal hypertension.
Hepatitis D
Specialty: Infectious Diseases
Category: Liver Infections
Sub-category: Chronic Viral Hepatitis
Symptoms:
fatigue; nausea; jaundice; dark urine; abdominal pain; joint pain
Root Cause:
Co-infection or superinfection with the Hepatitis D virus (HDV) in individuals already infected with Hepatitis B. HDV requires HBV to replicate.
How it's Diagnosed: videos
Blood tests for anti-HDV antibodies and HDV RNA, liver function tests.
Treatment:
Pegylated interferon-alpha; no specific antiviral therapy.
Medications:
Pegylated interferon-alpha to suppress viral replication; supportive care.
Prevalence:
How common the health condition is within a specific population.
Estimated 5–10% of individuals with HBV are co-infected with HDV.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Same as Hepatitis B, especially intravenous drug use and unprotected sex.
Prognosis:
The expected outcome or course of the condition over time.
Worse than HBV alone; higher risk of progression to cirrhosis and liver cancer.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Liver cirrhosis, hepatocellular carcinoma, liver failure.
Hepatitis E
Specialty: Infectious Diseases
Category: Liver Infections
Sub-category: Acute Viral Hepatitis
Symptoms:
fatigue; nausea; jaundice; dark urine; pale stools; abdominal pain; fever
Root Cause:
Infection with the Hepatitis E virus (HEV), often spread through contaminated water, leading to acute liver inflammation.
How it's Diagnosed: videos
Blood tests for anti-HEV antibodies (IgM), HEV RNA in serum or stool.
Treatment:
Supportive care; ribavirin in severe or chronic cases (e.g., immunocompromised patients).
Medications:
Ribavirin (antiviral, used selectively for chronic cases).
Prevalence:
How common the health condition is within a specific population.
Affects over 20 million people annually, primarily in developing regions.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Contaminated water, poor sanitation, undercooked pork or wild game meat.
Prognosis:
The expected outcome or course of the condition over time.
Full recovery in most cases; higher mortality in pregnant women.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Acute liver failure, particularly in pregnant women or immunocompromised individuals.
Pancreatic Necrosis and Pancreatic Abscess
Specialty: Infectious Diseases
Category: Gastrointestinal Tract and Intra-abdominal Infections
Symptoms:
severe abdominal pain; fever; nausea; vomiting; abdominal tenderness; tachycardia; jaundice in severe cases
Root Cause:
Pancreatic necrosis involves the death of pancreatic tissue due to severe inflammation or infection, often following acute pancreatitis. Pancreatic abscess is a collection of pus resulting from infected necrotic tissue or fluid accumulation.
How it's Diagnosed: videos
Diagnosed through clinical evaluation, imaging studies (CT scan or MRI), and blood tests including elevated white blood cell count, CRP, and amylase/lipase levels. Fine-needle aspiration (FNA) may confirm infection.
Treatment:
Treatment includes supportive care, drainage of abscesses, and, in severe cases, surgical debridement or necrosectomy. Antibiotics are used to manage infections.
Medications:
Antibiotics such as carbapenems (e.g., meropenem ), third-generation cephalosporins (e.g., ceftriaxone ), or fluoroquinolones (e.g., ciprofloxacin ) combined with metronidazole to cover anaerobes. These are classified as broad-spectrum antibiotics. Pain management includes opioids like morphine or hydromorphone .
Prevalence:
How common the health condition is within a specific population.
Rare but occurs in 10-20% of cases of severe acute pancreatitis.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Alcohol abuse, gallstones, hyperlipidemia, pancreatic trauma, and delayed or inadequate treatment of acute pancreatitis.
Prognosis:
The expected outcome or course of the condition over time.
Prognosis depends on early diagnosis and treatment. Mortality rates can reach 30-50% in cases of infected necrosis or untreated abscesses.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Sepsis, multiorgan failure, hemorrhage, diabetes mellitus, and chronic pancreatitis.
Recurrent Pyogenic Cholangitis
Specialty: Infectious Diseases
Category: Gastrointestinal Tract and Intra-abdominal Infections
Symptoms:
jaundice; recurrent abdominal pain; fever with chills; malaise; pruritus
Root Cause:
Chronic bacterial infections and inflammation of the bile ducts, often associated with biliary obstruction, stones, or parasites like liver flukes.
How it's Diagnosed: videos
Ultrasound, CT, or MRI (especially MRCP) to visualize biliary stones or strictures. Laboratory tests show elevated liver enzymes, bilirubin, and white blood cell counts.
Treatment:
Endoscopic or surgical removal of stones, biliary drainage, and treatment of infections with antibiotics. Long-term monitoring for recurrence is necessary.
Medications:
Broad-spectrum antibiotics like piperacillin-tazobactam, fluoroquinolones (e.g., ciprofloxacin ), or cephalosporins (e.g., ceftriaxone ) to treat infections. Ursodeoxycholic acid may help prevent stone formation.
Prevalence:
How common the health condition is within a specific population.
Common in Southeast Asia; less prevalent in Western countries.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
History of biliary tract infection, gallstones, parasitic infections, and bile duct strictures.
Prognosis:
The expected outcome or course of the condition over time.
Good with timely treatment, but recurrence is common. Risk of cholangiocarcinoma in chronic cases.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Sepsis, biliary cirrhosis, liver abscesses, and bile duct cancer.
Salmonella Infection (Salmonellosis)
Specialty: Infectious Diseases
Category: Gastrointestinal Tract and Intra-abdominal Infections
Symptoms:
diarrhea; fever; abdominal cramps; nausea; vomiting; headache
Root Cause:
Infection by Salmonella bacteria, typically via contaminated food, water, or contact with infected animals.
How it's Diagnosed: videos
Stool culture, blood culture in severe cases, and molecular testing (PCR) to identify Salmonella species.
Treatment:
Supportive care with fluids and electrolytes; antibiotics (only for severe cases).
Medications:
Antibiotics like ciprofloxacin , azithromycin , or ceftriaxone for severe or systemic infections. These are classified as fluoroquinolones, macrolides, and third-generation cephalosporins, respectively.
Prevalence:
How common the health condition is within a specific population.
Common worldwide; significant in developing regions due to poor sanitation.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Consumption of contaminated food, immunosuppression, and travel to endemic regions.
Prognosis:
The expected outcome or course of the condition over time.
Self-limited in most cases; good with appropriate treatment for severe cases.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Dehydration, bacteremia, reactive arthritis, and localized infections (e.g., osteomyelitis).
Shigellosis
Specialty: Infectious Diseases
Category: Gastrointestinal Tract and Intra-abdominal Infections
Symptoms:
bloody diarrhea; fever; abdominal cramps; tenesmus; fatigue
Root Cause:
Infection of the intestines by Shigella species, causing inflammation and ulceration of the colonic mucosa.
How it's Diagnosed: videos
Stool culture, PCR, or antigen detection tests to confirm Shigella infection.
Treatment:
Rehydration therapy and antibiotics for severe cases.
Medications:
Antibiotics like ciprofloxacin , azithromycin , or ceftriaxone .
Prevalence:
How common the health condition is within a specific population.
Common worldwide, especially in areas with poor sanitation.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Contaminated food or water, overcrowded living conditions, and young age.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with treatment; self-limiting in mild cases.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Dehydration, hemolytic uremic syndrome (HUS), and reactive arthritis.
Small Intestinal Diverticulosis
Specialty: Infectious Diseases
Category: Gastrointestinal Tract and Intra-abdominal Infections
Symptoms:
abdominal discomfort; bloating; nausea; vomiting; diarrhea or constipation; occult gastrointestinal bleeding in some cases
Root Cause:
Formation of diverticula (small pouches) in the small intestine, often due to increased intraluminal pressure or connective tissue weakness.
How it's Diagnosed: videos
Radiographic imaging (CT scan, small bowel follow-through, or capsule endoscopy) and incidental findings during evaluations for other conditions.
Treatment:
Mostly asymptomatic; dietary modifications and antibiotics for diverticulitis. Surgery in cases of complications like perforation.
Medications:
Antibiotics such as ciprofloxacin and metronidazole for diverticulitis. Prokinetics may be used for motility issues.
Prevalence:
How common the health condition is within a specific population.
Rare; increases with age.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Older age, connective tissue disorders, and motility disorders.
Prognosis:
The expected outcome or course of the condition over time.
Good in asymptomatic cases; complications may worsen outcomes.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Diverticulitis, perforation, fistula, and small bowel obstruction.
Strongyloidiasis
Specialty: Infectious Diseases
Category: Gastrointestinal Tract and Intra-abdominal Infections
Sub-category: Parasitic Infections
Symptoms:
abdominal pain; diarrhea; weight loss; itchy skin rash; cough or wheezing in disseminated cases
Root Cause:
Chronic intestinal infection caused by the parasitic nematode Strongyloides stercoralis, with potential for autoinfection and systemic dissemination.
How it's Diagnosed: videos
Stool examination, serological tests (antibody detection), or PCR. Larvae may also be identified in duodenal aspirates or sputum in disseminated cases.
Treatment:
Anti-parasitic therapy with ivermectin or albendazole.
Medications:
Ivermectin (first-line) or albendazole (alternative). Both are anti-helminthic drugs.
Prevalence:
How common the health condition is within a specific population.
Common in tropical and subtropical regions; less frequent in temperate areas.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Poor sanitation, immunosuppression, corticosteroid use, and travel to endemic regions.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with timely treatment; life-threatening in disseminated strongyloidiasis.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Hyperinfection syndrome, sepsis, and respiratory distress in severe cases.
Viral Gastroenteritis
Specialty: Infectious Diseases
Category: Gastrointestinal Tract and Intra-abdominal Infections
Symptoms:
watery diarrhea; nausea; vomiting; fever; abdominal cramps; dehydration
Root Cause:
Inflammation of the stomach and intestines caused by viral infections (e.g., norovirus, rotavirus, adenovirus).
How it's Diagnosed: videos
Clinical diagnosis based on symptoms; stool PCR or antigen tests in specific cases.
Treatment:
Supportive care, including rehydration and electrolyte replacement. Antiemetics may be used for severe nausea.
Medications:
No specific antiviral treatment; oral rehydration solutions (ORS) and antiemetics like ondansetron may be used.
Prevalence:
How common the health condition is within a specific population.
Very common worldwide, especially in children and in areas with poor sanitation.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Close contact with infected individuals, contaminated food or water, poor hand hygiene.
Prognosis:
The expected outcome or course of the condition over time.
Excellent in most cases with supportive care; severe dehydration can be life-threatening without treatment.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Dehydration, electrolyte imbalances, and in rare cases, kidney injury.
Yellow Fever
Specialty: Infectious Diseases
Category: Gastrointestinal Tract and Intra-abdominal Infections
Symptoms:
fever; headache; muscle pain; nausea; vomiting; jaundice; abdominal pain; bleeding (e.g., from the gums or nose); organ failure in severe cases
Root Cause:
Yellow fever is caused by the yellow fever virus, a flavivirus transmitted by infected mosquitoes (primarily Aedes aegypti). It leads to systemic infection, liver damage, and subsequent jaundice and bleeding tendencies in severe cases.
How it's Diagnosed: videos
Diagnosed through serologic tests or PCR.
Treatment:
Treated supportively, as no specific antiviral therapy exists, with vaccination as a key preventive measure.
Medications:
No antiviral medications are available for yellow fever. Supportive medications include antipyretics like acetaminophen (avoid NSAIDs like ibuprofen or aspirin to reduce bleeding risks) and intravenous fluids for dehydration. Hemostatic agents may be used in cases of severe bleeding.
Prevalence:
How common the health condition is within a specific population.
Yellow fever is endemic in tropical areas of Africa and South America. Annually, it causes an estimated 200,000 cases and 30,000 deaths globally, with most cases unreported.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Traveling to or living in endemic areas, lack of vaccination, and exposure to mosquito bites.
Prognosis:
The expected outcome or course of the condition over time.
In mild cases, recovery occurs within days to weeks without long-term effects. Severe cases with complications like liver failure or bleeding have a mortality rate of 20–50%. Survivors of severe cases typically recover fully but may require prolonged convalescence.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Hepatic failure, renal failure, shock, disseminated intravascular coagulation (DIC), multi-organ failure, and death in severe cases.
Catheter-Related Urinary Tract Infection (UTI)
Specialty: Infectious Diseases
Category: Genitourinary Tract Infections
Symptoms:
fever; chills; cloudy or foul-smelling urine; lower abdominal or back pain; burning sensation during urination (if catheter removed); frequent urination (if catheter removed)
Root Cause:
Bacterial infection caused by microorganisms entering the urinary tract through the catheter, often exacerbated by prolonged catheterization.
How it's Diagnosed: videos
Urinalysis, urine culture to identify causative bacteria, clinical history, and symptoms.
Treatment:
Prompt catheter removal or replacement, antibiotics targeting the identified pathogen, hydration to flush out the urinary tract.
Medications:
Antibiotics such as fluoroquinolones (ciprofloxacin , levofloxacin ), trimethoprim-sulfamethoxazole, or beta-lactams (amoxicillin-clavulanate). These medications are classified as antimicrobials.
Prevalence:
How common the health condition is within a specific population.
Common among hospitalized patients or individuals requiring long-term catheterization, with an estimated prevalence of 5–10% per day of catheter use.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Prolonged catheter use, poor catheter hygiene, older age, immunosuppression, diabetes, female gender.
Prognosis:
The expected outcome or course of the condition over time.
Typically resolves with appropriate treatment, but recurrent infections or severe cases can lead to complications such as sepsis.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Pyelonephritis, sepsis, multi-drug-resistant infections, bladder damage.
Cervicitis
Specialty: Infectious Diseases
Category: Reproductive System Infections
Sub-category: Inflammatory Disorders
Symptoms:
abnormal vaginal discharge; pelvic pain; pain during intercourse; bleeding between periods; burning sensation during urination
Root Cause:
Inflammation of the cervix due to infection (e.g., Chlamydia trachomatis, Neisseria gonorrhoeae) or non-infectious irritants like allergens or chemical irritants.
How it's Diagnosed: videos
Pelvic exam, cervical swab for culture or PCR testing, and exclusion of other reproductive system infections.
Treatment:
Antibiotic therapy for infectious causes, removal of irritants for non-infectious causes.
Medications:
Azithromycin (macrolide antibiotic) or doxycycline (tetracycline antibiotic); sometimes combined with ceftriaxone (beta-lactam antibiotic) for gonococcal infection.
Prevalence:
How common the health condition is within a specific population.
Prevalent among sexually active women; exact prevalence varies depending on risk factors and population.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Multiple sexual partners, unprotected sex, prior history of sexually transmitted infections (STIs).
Prognosis:
The expected outcome or course of the condition over time.
Treatable with appropriate therapy, but untreated infections can lead to complications like pelvic inflammatory disease.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Pelvic inflammatory disease, infertility, chronic pelvic pain, increased risk of ectopic pregnancy.
Chronic Pelvic Pain in Men
Specialty: Infectious Diseases
Category: Chronic Pain Disorders
Sub-category: Urological Pain
Symptoms:
persistent pelvic pain lasting more than six months; pain during urination; difficulty urinating; pain during ejaculation; testicular or perineal discomfort
Root Cause:
Multifactorial, including pelvic floor muscle dysfunction, inflammation, or nerve hypersensitivity; sometimes associated with chronic prostatitis.
How it's Diagnosed: videos
Patient history, physical examination, urinalysis, imaging studies (e.g., ultrasound), and exclusion of other conditions.
Treatment:
Multimodal approach including pain management, physical therapy, psychological support, and sometimes antibiotics or alpha-blockers.
Medications:
Alpha-blockers (tamsulosin ), antibiotics (if infectious component suspected), and pain relievers (NSAIDs); occasionally antidepressants (amitriptyline ) or neuropathic pain medications (gabapentin ).
Prevalence:
How common the health condition is within a specific population.
Affects up to 10% of men; most common in middle-aged adults.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
History of UTIs, sedentary lifestyle, stress, previous pelvic surgery or trauma.
Prognosis:
The expected outcome or course of the condition over time.
Chronic but manageable with appropriate interventions; symptoms often improve with combined treatments.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Sexual dysfunction, urinary retention, reduced quality of life.
Cystitis Empiric Therapy
Specialty: Infectious Diseases
Category: Genitourinary Tract Infections
Sub-category: Acute Cystitis
Symptoms:
frequent and painful urination; urgency to urinate; cloudy or blood-tinged urine; lower abdominal pain or discomfort; mild fever in some cases
Root Cause:
Bacterial infection (commonly Escherichia coli) causing inflammation of the bladder wall.
How it's Diagnosed: videos
Clinical symptoms, urinalysis for leukocytes and nitrites, and urine culture for definitive diagnosis.
Treatment:
Initiation of empirical antibiotics while awaiting culture results, hydration, and symptomatic management.
Medications:
Nitrofurantoin (urinary antiseptic), trimethoprim-sulfamethoxazole (antibiotic combination), or fosfomycin (broad-spectrum antibiotic).
Prevalence:
How common the health condition is within a specific population.
Common, particularly in women; about 50–60% of women experience cystitis at least once in their lifetime.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Female gender, sexual activity, use of spermicides, postmenopausal status, diabetes, and catheter use.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with appropriate treatment; symptoms typically resolve within a few days of starting antibiotics.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Pyelonephritis, recurrent infections, and multi-drug resistance.
Nonbacterial Prostatitis
Specialty: Infectious Diseases
Category: Chronic Pelvic Pain Disorders
Sub-category: Prostatitis Syndromes
Symptoms:
pelvic pain; difficulty urinating; pain during ejaculation; testicular discomfort; frequent urination; low-grade fever (occasionally)
Root Cause:
Inflammation of the prostate without evidence of bacterial infection, possibly due to autoimmune, stress, or muscle spasm factors.
How it's Diagnosed: videos
Exclusion of bacterial infection through urinalysis and culture, prostate fluid examination, and symptom assessment.
Treatment:
Multimodal approach including pain management, pelvic floor therapy, and lifestyle modifications.
Medications:
Alpha-blockers (tamsulosin ), anti-inflammatory medications (ibuprofen ), and occasionally neuropathic pain medications (amitriptyline ) or muscle relaxants (diazepam ).
Prevalence:
How common the health condition is within a specific population.
Accounts for 90–95% of chronic prostatitis cases; common in men aged 30–50 years.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Stress, sedentary lifestyle, previous urological infections, pelvic trauma.
Prognosis:
The expected outcome or course of the condition over time.
Chronic but manageable; symptoms often fluctuate in intensity and respond variably to treatment.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Sexual dysfunction, urinary retention, psychological distress.
Papillary Necrosis
Specialty: Infectious Diseases
Category: Renal Disorders
Sub-category: Ischemic or Toxic Nephropathy
Symptoms:
hematuria (blood in urine); flank pain; fever; proteinuria; reduced urine output; renal colic symptoms
Root Cause:
Necrosis of renal papillae due to ischemia or direct toxicity, often secondary to conditions like diabetes, sickle cell disease, or NSAID overuse.
How it's Diagnosed: videos
Imaging studies such as ultrasound, CT scan, or MRI, urinalysis, and renal function tests.
Treatment:
Addressing the underlying cause, hydration, supportive care, and avoiding nephrotoxic agents.
Medications:
Management includes antibiotics (if infection is present) and analgesics (carefully avoiding nephrotoxic drugs).
Prevalence:
How common the health condition is within a specific population.
Rare; commonly associated with predisposing conditions like diabetes or analgesic abuse.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Diabetes, sickle cell disease, chronic NSAID use, pyelonephritis, dehydration.
Prognosis:
The expected outcome or course of the condition over time.
Variable; mild cases resolve with treatment, but severe cases can lead to chronic kidney disease or renal failure.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Acute kidney injury, recurrent urinary tract infections, chronic kidney disease.
Pathophysiology of Complicated Urinary Tract Infection (UTI)
Specialty: Infectious Diseases
Category: Genitourinary Tract Infections
Symptoms:
frequent urination; painful urination (dysuria); fever; flank pain; hematuria; cloudy or foul-smelling urine; fatigue
Root Cause:
Structural or functional abnormalities of the urinary tract, immune compromise, or bacterial resistance leading to persistent or severe infection.
How it's Diagnosed: videos
Urine culture, urinalysis, imaging studies (CT, ultrasound), blood tests for systemic infection markers.
Treatment:
Tailored antibiotic therapy based on culture results, addressing underlying abnormalities, hydration, and supportive care.
Medications:
Fluoroquinolones (e.g., ciprofloxacin ) or extended-spectrum cephalosporins (e.g., ceftriaxone ) are common; carbapenems (e.g., meropenem ) may be used for multidrug-resistant cases. These are classified as antibiotics.
Prevalence:
How common the health condition is within a specific population.
Complicated UTIs represent approximately 20–30% of urinary tract infections, more common in hospitalized or immunocompromised patients.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Catheter use, kidney stones, diabetes, pregnancy, immune suppression, anatomical abnormalities.
Prognosis:
The expected outcome or course of the condition over time.
Generally good with appropriate treatment, but can lead to recurrent infections or systemic complications if untreated.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Pyelonephritis, sepsis, renal abscess, chronic kidney disease.
Perinephric Abscess
Specialty: Infectious Diseases
Category: Genitourinary Tract Infections
Sub-category: Renal Infections
Symptoms:
flank pain; fever; chills; nausea and vomiting; weight loss
Root Cause:
Collection of pus around the kidney, often due to untreated pyelonephritis or hematogenous bacterial spread.
How it's Diagnosed: videos
Imaging studies (CT scan or ultrasound), blood cultures, urinalysis.
Treatment:
Drainage of the abscess via percutaneous or surgical methods, antibiotic therapy targeting causative organisms.
Medications:
Piperacillin-tazobactam (a beta-lactam antibiotic) or vancomycin combined with ceftriaxone to address resistant bacteria.
Prevalence:
How common the health condition is within a specific population.
Rare, accounting for less than 1% of urinary tract infections, often seen in immunocompromised individuals.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Diabetes, renal calculi, recent urinary tract surgery, immunosuppression.
Prognosis:
The expected outcome or course of the condition over time.
Good with prompt drainage and antibiotic therapy; delayed treatment can lead to severe complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Sepsis, chronic renal impairment, rupture into adjacent structures.
Pyonephrosis
Specialty: Infectious Diseases
Category: Genitourinary Tract Infections
Symptoms:
fever; flank pain; chills; nausea; vomiting; cloudy or foul-smelling urine
Root Cause:
Accumulation of pus in the renal collecting system, often caused by an obstructive uropathy combined with infection.
How it's Diagnosed: videos
Ultrasound or CT imaging to detect hydronephrosis with echogenic debris; urine culture to identify infection; blood tests to check for systemic infection.
Treatment:
Drainage of pus through percutaneous nephrostomy or surgery; broad-spectrum antibiotics followed by culture-guided antibiotics.
Medications:
Broad-spectrum antibiotics such as piperacillin-tazobactam (beta-lactam/beta-lactamase inhibitor), carbapenems (e.g., meropenem ), or fluoroquinolones (e.g., ciprofloxacin ).
Prevalence:
How common the health condition is within a specific population.
Rare; more common in patients with urinary obstruction or immunocompromised states.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Kidney stones, urinary tract obstruction, diabetes, immunosuppression, prior urinary infections.
Prognosis:
The expected outcome or course of the condition over time.
Good with timely drainage and appropriate antibiotics; untreated cases can lead to sepsis and renal failure.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Sepsis, renal abscess, permanent kidney damage, or renal failure.
Renal Corticomedullary Abscess
Specialty: Infectious Diseases
Category: Genitourinary Tract Infections
Symptoms:
flank pain; fever; chills; malaise; dysuria; hematuria
Root Cause:
Localized bacterial infection leading to the formation of pus in the renal cortex or medulla.
How it's Diagnosed: videos
Contrast-enhanced CT scan or ultrasound to identify abscess; blood and urine cultures to identify causative organisms.
Treatment:
Antibiotics targeting common pathogens (e.g., E. coli, Klebsiella) and percutaneous or surgical drainage if abscess size is significant (>5 cm).
Medications:
Antibiotics like ceftriaxone (cephalosporin), aminoglycosides (e.g., gentamicin ), or fluoroquinolones (e.g., levofloxacin ).
Prevalence:
How common the health condition is within a specific population.
Rare; more frequent in diabetic or immunocompromised individuals.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Diabetes, kidney stones, prior pyelonephritis, urinary obstruction, immunosuppression.
Prognosis:
The expected outcome or course of the condition over time.
Good with appropriate treatment; untreated cases risk systemic infection or chronic kidney damage.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic abscess formation, sepsis, renal scarring, or spread of infection to adjacent organs.
Trigonitis
Specialty: Infectious Diseases
Category: Genitourinary Tract Infections
Symptoms:
pelvic pain; frequent urination; burning sensation during urination; urgency; cloudy or bloody urine
Root Cause:
Chronic inflammation of the bladder trigone, often associated with repeated infections or irritation.
How it's Diagnosed: videos
Cystoscopy to visualize inflammation or changes in the bladder trigone area; urinalysis to rule out active infection.
Treatment:
Addressing the underlying cause (e.g., infections or irritants), bladder instillations, and medications for symptom relief.
Medications:
Antibiotics for bacterial infection (e.g., nitrofurantoin ), anticholinergics (e.g., oxybutynin ) for overactive bladder symptoms, or local anesthetics (e.g., lidocaine instillations).
Prevalence:
How common the health condition is within a specific population.
Common in individuals with recurrent urinary infections; more prevalent in women.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Recurrent UTIs, use of indwelling catheters, hormonal changes, bladder irritants (e.g., caffeine, spicy foods).
Prognosis:
The expected outcome or course of the condition over time.
Good with management; chronic symptoms may persist if underlying causes are not addressed.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic pelvic pain, recurrent infections, reduced bladder capacity, or bladder wall thickening.
Urinary Tract Infection (UTI) and Cystitis (Bladder Infection) in Females
Specialty: Infectious Diseases
Category: Genitourinary Tract Infections
Symptoms:
frequent urination; burning sensation during urination; urgency; lower abdominal pain; cloudy or foul-smelling urine
Root Cause:
Bacterial infection, commonly E. coli, ascending from the urethra to the bladder.
How it's Diagnosed: videos
Urinalysis and urine culture to identify pathogens; dipstick test for leukocytes and nitrites.
Treatment:
Short courses of antibiotics; increased fluid intake and symptom management.
Medications:
First-line antibiotics include nitrofurantoin (antibiotic), trimethoprim-sulfamethoxazole (antibiotic combination), or fosfomycin (antibiotic). Symptomatic relief with phenazopyridine (urinary analgesic).
Prevalence:
How common the health condition is within a specific population.
Very common; affects approximately 50-60% of women at least once in their lifetime.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Sexual activity, use of spermicides, prior UTIs, menopause, diabetes, urinary retention.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with treatment; untreated cases may progress to pyelonephritis or sepsis.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Recurrent UTIs, pyelonephritis, kidney damage in severe cases, or urosepsis.
Urinary Tract Infection (UTI) in Males
Specialty: Infectious Diseases
Category: Genitourinary Tract Infections
Symptoms:
frequent urination; burning sensation during urination; cloudy or strong-smelling urine; pelvic pain; fever; chills
Root Cause:
Bacterial infection of the urinary tract, typically caused by Escherichia coli or other gram-negative bacteria.
How it's Diagnosed: videos
Urinalysis, urine culture, and physical examination. Imaging (e.g., ultrasound, CT scan) in recurrent or complicated cases.
Treatment:
Antibiotics specific to the organism causing the infection, increased hydration, and symptom management.
Medications:
Fluoroquinolones (e.g., ciprofloxacin , levofloxacin ) or trimethoprim-sulfamethoxazole; both are antibiotics targeting bacterial infections.
Prevalence:
How common the health condition is within a specific population.
Less common in males compared to females; affects approximately 1-2% of males annually, higher in older men with prostate problems.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Benign prostatic hyperplasia (BPH), kidney stones, catheter use, diabetes, and weakened immune system.
Prognosis:
The expected outcome or course of the condition over time.
Generally good with prompt treatment; may lead to complications if untreated.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Prostatitis, kidney infections (pyelonephritis), or sepsis in severe cases.
Urinary Tract Infection Organism-Specific Therapy
Specialty: Infectious Diseases
Category: Genitourinary Tract Infections
Symptoms:
symptoms depend on specific organism but typically include urinary frequency; dysuria; urgency; fever
Root Cause:
UTIs caused by less common pathogens, including Proteus, Klebsiella, Pseudomonas, or multi-drug-resistant bacteria.
How it's Diagnosed: videos
Urine culture and sensitivity testing to identify the organism and determine antibiotic susceptibility.
Treatment:
Antibiotic therapy tailored to the identified organism.
Medications:
Antibiotics such as cephalosporins, carbapenems (e.g., meropenem ), or aminoglycosides (e.g., gentamicin ) depending on bacterial resistance.
Prevalence:
How common the health condition is within a specific population.
Rare; occurs in patients with prior antibiotic use, hospital-acquired infections, or immunocompromised conditions.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Prolonged catheterization, previous UTIs, antibiotic resistance.
Prognosis:
The expected outcome or course of the condition over time.
Depends on the organism and timeliness of treatment; good with effective therapy.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic infections, abscess formation, or systemic infection (e.g., sepsis).
Urinary Tract Infections (UTI) in Diabetes Mellitus
Specialty: Infectious Diseases
Category: Genitourinary Tract Infections
Symptoms:
frequent urination; painful urination; incomplete bladder emptying; fatigue; fever
Root Cause:
Hyperglycemia leading to immune dysfunction and increased bacterial colonization in the urinary tract.
How it's Diagnosed: videos
Urinalysis, urine culture, blood glucose testing, and assessment for underlying complications.
Treatment:
Antibiotics targeting the causative organism, glycemic control, and preventive measures.
Medications:
Nitrofurantoin , trimethoprim-sulfamethoxazole, or fluoroquinolones, depending on the organism and resistance.
Prevalence:
How common the health condition is within a specific population.
More frequent in diabetic patients, with an estimated 2-3x higher risk than the general population.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Poor glycemic control, recurrent UTIs, neuropathy affecting bladder emptying.
Prognosis:
The expected outcome or course of the condition over time.
Good with early intervention and management of blood sugar levels.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Pyelonephritis, emphysematous cystitis, or urosepsis.
Urinary Tract Infections in Pregnancy
Specialty: Infectious Diseases
Category: Genitourinary Tract Infections
Symptoms:
burning urination; pelvic discomfort; cloudy urine; fever in severe cases
Root Cause:
Hormonal and anatomical changes in pregnancy leading to urinary stasis and increased susceptibility to infections.
How it's Diagnosed: videos
Routine urinalysis and urine culture during prenatal visits.
Treatment:
Safe antibiotics for pregnancy, hydration, and regular follow-up.
Medications:
Amoxicillin , cephalexin , or nitrofurantoin (avoided in the first trimester and near-term).
Prevalence:
How common the health condition is within a specific population.
Common; affects up to 10% of pregnant women.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Hormonal changes, anatomical changes, history of UTIs, diabetes.
Prognosis:
The expected outcome or course of the condition over time.
Favorable with treatment; risk of preterm labor if untreated.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Pyelonephritis, preterm birth, or low birth weight.
Urinary Tract Infections in Spinal Cord Injury
Specialty: Infectious Diseases
Category: Genitourinary Tract Infections
Symptoms:
fever; spasticity; cloudy urine; autonomic dysreflexia
Root Cause:
Neurogenic bladder and impaired voiding increase risk for bacterial growth.
How it's Diagnosed: videos
Urine culture, assessment of bladder management methods (e.g., catheterization).
Treatment:
Antibiotics and optimization of bladder emptying strategies.
Medications:
Fluoroquinolones or aminoglycosides for resistant infections.
Prevalence:
How common the health condition is within a specific population.
Common in spinal cord injury patients; prevalence ranges from 30-60%.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Indwelling catheters, incomplete bladder emptying.
Prognosis:
The expected outcome or course of the condition over time.
Manageable; recurrence is common without preventive measures.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Kidney damage, recurrent infections, autonomic dysreflexia.
Variant Creutzfeldt-Jakob Disease and Bovine Spongiform Encephalopathy
Specialty: Infectious Diseases
Category: Neurodegenerative Disorders
Sub-category: Prion Diseases
Symptoms:
progressive dementia; psychiatric symptoms; muscle stiffness; myoclonus
Root Cause:
Accumulation of abnormal prion proteins in the brain, leading to neurodegeneration.
How it's Diagnosed: videos
Brain MRI, cerebrospinal fluid (CSF) testing for prion markers, and post-mortem examination.
Treatment:
Supportive care only; no curative treatment available.
Medications:
Symptom management with antipsychotics, sedatives, or muscle relaxants.
Prevalence:
How common the health condition is within a specific population.
Extremely rare; associated with exposure to infected cattle products.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Consumption of contaminated beef products or exposure to prions.
Prognosis:
The expected outcome or course of the condition over time.
Fatal; average survival is about 12-14 months post-symptom onset.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Progressive neurological decline, severe disability, and death.
Acute Rhinosinusitis Empiric Therapy
Specialty: Infectious Diseases
Category: HEENT Infections
Symptoms:
nasal congestion; purulent nasal discharge; facial pain/pressure; fever; headache; reduced or lost sense of smell
Root Cause:
Inflammation and infection of the paranasal sinuses, usually caused by viral or bacterial pathogens.
How it's Diagnosed: videos
Clinical history and physical examination; imaging (CT scan of sinuses) in complicated or atypical cases.
Treatment:
Supportive care, empiric antibiotics for suspected bacterial infection, and adjunctive therapies such as nasal saline irrigation and decongestants.
Medications:
First-line empiric antibiotics include amoxicillin-clavulanate (a penicillin-class antibiotic). Alternatives for penicillin-allergic patients may include doxycycline (a tetracycline-class antibiotic) or respiratory fluoroquinolones like levofloxacin or moxifloxacin .
Prevalence:
How common the health condition is within a specific population.
Acute rhinosinusitis is highly common, affecting approximately 1 in 8 adults annually.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Allergies, recent upper respiratory infections, smoking, structural abnormalities (e.g., deviated septum).
Prognosis:
The expected outcome or course of the condition over time.
Viral rhinosinusitis typically resolves in 7-10 days; bacterial cases improve with appropriate antibiotic therapy.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Orbital cellulitis, abscess formation, meningitis, or chronic rhinosinusitis in rare cases.
Acute Rhinosinusitis Organism-Specific Therapy
Specialty: Infectious Diseases
Category: HEENT Infections
Symptoms:
nasal congestion; purulent nasal discharge; facial pain/pressure; fever; headache; postnasal drip
Root Cause:
Infection of the sinuses by specific organisms, such as Streptococcus pneumoniae, Haemophilus influenzae, or Moraxella catarrhalis.
How it's Diagnosed: videos
Clinical signs and symptoms, culture from sinus aspirate (in severe or recurrent cases).
Treatment:
Antibiotics tailored to the identified organism; supportive care as needed.
Medications:
For S. pneumoniae and H. influenzae, amoxicillin-clavulanate is commonly used. Alternatives include cefuroxime (a second-generation cephalosporin) or levofloxacin (a fluoroquinolone). For penicillin-allergic patients, clindamycin combined with a cephalosporin may be used.
Prevalence:
How common the health condition is within a specific population.
Similar to empiric acute rhinosinusitis; bacterial cases occur in approximately 0.5-2% of viral sinusitis episodes.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Immunosuppression, incomplete resolution of prior infections, recurrent upper respiratory infections.
Prognosis:
The expected outcome or course of the condition over time.
Good with appropriate antibiotic therapy; untreated bacterial infections may progress to complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Orbital cellulitis, abscesses, or intracranial infections.
Acute Sinusitis
Specialty: Infectious Diseases
Category: HEENT Infections
Symptoms:
nasal congestion; purulent nasal discharge; facial pressure; headache; tooth pain; postnasal drip
Root Cause:
Inflammation of the sinus lining due to viral, bacterial, or fungal pathogens.
How it's Diagnosed: videos
Based on clinical presentation; imaging studies (CT or MRI) in cases of suspected complications.
Treatment:
Supportive care for viral causes; antibiotics for bacterial cases; antifungals for fungal infections.
Medications:
First-line treatment involves amoxicillin-clavulanate for bacterial sinusitis. Alternatives for allergies or resistance include doxycycline , levofloxacin , or trimethoprim-sulfamethoxazole (a sulfonamide antibiotic).
Prevalence:
How common the health condition is within a specific population.
Affects up to 1 in 7 adults annually in the U.S.; most cases are viral.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Allergic rhinitis, nasal polyps, dental infections, smoking, air pollution.
Prognosis:
The expected outcome or course of the condition over time.
Most cases resolve without complications; bacterial cases respond well to antibiotics.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic sinusitis, orbital or intracranial infections.
Bacterial Pharyngitis
Specialty: Infectious Diseases
Category: HEENT Infections
Symptoms:
sore throat; fever; difficulty swallowing; swollen lymph nodes; red throat with or without exudates
Root Cause:
Inflammation of the pharynx caused by bacterial pathogens, most commonly Group A Streptococcus (GAS).
How it's Diagnosed: videos
Rapid antigen detection test (RADT) for GAS; throat culture as the gold standard.
Treatment:
Antibiotic therapy to eradicate the infection, reduce symptoms, and prevent complications.
Medications:
Penicillin V or amoxicillin is the first-line treatment. For penicillin-allergic patients, alternatives include azithromycin or clindamycin (macrolide and lincosamide antibiotics, respectively).
Prevalence:
How common the health condition is within a specific population.
GAS causes 20-30% of pharyngitis in children and 5-15% in adults.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Close contact with infected individuals, young age, crowded living conditions.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with prompt treatment; untreated infections may lead to complications like rheumatic fever or glomerulonephritis.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Rheumatic fever, post-streptococcal glomerulonephritis, peritonsillar abscess.
Chronic Rhinosinusitis Empiric Therapy
Specialty: Infectious Diseases
Category: HEENT Infections
Symptoms:
nasal congestion; nasal discharge; facial pain or pressure; loss of smell; postnasal drip; headache; fatigue
Root Cause:
Persistent inflammation of the paranasal sinuses lasting longer than 12 weeks, often due to a combination of infection, allergy, and immune dysfunction.
How it's Diagnosed: videos
Based on clinical presentation, physical examination, nasal endoscopy, and imaging studies (CT or MRI).
Treatment:
Initial treatment with empiric broad-spectrum antibiotics, nasal corticosteroids, saline irrigation, and sometimes oral steroids. Surgical intervention (e.g., functional endoscopic sinus surgery) for refractory cases.
Medications:
Empiric antibiotics like amoxicillin-clavulanate or doxycycline for bacterial infection; nasal corticosteroids (e.g., fluticasone or mometasone ); saline nasal irrigation.
Prevalence:
How common the health condition is within a specific population.
Affects approximately 1-2% of the population globally, with higher prevalence in individuals with allergies or asthma.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Allergies, asthma, smoking, environmental pollutants, nasal polyps, immunodeficiency.
Prognosis:
The expected outcome or course of the condition over time.
Often chronic but manageable with medical or surgical interventions; may require ongoing treatment.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Orbital cellulitis, abscess formation, intracranial infections, and osteomyelitis in severe cases.
Chronic Rhinosinusitis Organism-Specific Therapy
Specialty: Infectious Diseases
Category: HEENT Infections
Symptoms:
nasal congestion; purulent nasal discharge; facial pain or swelling; fever; chronic cough
Root Cause:
Chronic infection by specific organisms, such as Staphylococcus aureus, Pseudomonas aeruginosa, or fungal species like Aspergillus.
How it's Diagnosed: videos
Culture and sensitivity testing from nasal or sinus samples, supported by imaging.
Treatment:
Directed antimicrobial therapy based on the identified organism; antifungal therapy for fungal infections.
Medications:
Antibiotics tailored to the organism, such as vancomycin for S. aureus or ciprofloxacin for Pseudomonas. Antifungal agents like voriconazole or amphotericin B for fungal infections.
Prevalence:
How common the health condition is within a specific population.
Less common than non-specific chronic rhinosinusitis; higher in immunocompromised individuals.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Immune suppression, chronic diseases, frequent antibiotic use.
Prognosis:
The expected outcome or course of the condition over time.
Depends on the underlying organism and timely initiation of appropriate therapy; refractory cases may require surgery.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Fungal invasion leading to tissue destruction, systemic infection, and life-threatening complications in severe cases.
Chronic Sinusitis
Specialty: Infectious Diseases
Category: HEENT Infections
Symptoms:
persistent nasal congestion; nasal discharge; facial pain; pressure around the eyes; chronic cough; fatigue
Root Cause:
Chronic inflammation and infection of the sinus linings, often associated with structural abnormalities or immune dysfunction.
How it's Diagnosed: videos
Clinical history, physical exam, nasal endoscopy, and imaging studies.
Treatment:
Combination of antibiotics, nasal corticosteroids, and saline irrigation. Surgery for refractory or complicated cases.
Medications:
Amoxicillin-clavulanate or levofloxacin for bacterial infections; intranasal corticosteroids such as fluticasone or budesonide .
Prevalence:
How common the health condition is within a specific population.
Approximately 12% of adults in the U.S. experience it annually.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Allergies, asthma, smoking, structural abnormalities (e.g., deviated septum), immunodeficiency.
Prognosis:
The expected outcome or course of the condition over time.
Manageable with appropriate therapy; surgery can provide long-term relief for severe cases.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Orbital cellulitis, brain abscess, meningitis, and osteomyelitis.
Herpangina
Specialty: Infectious Diseases
Category: HEENT Infections
Symptoms:
sore throat; fever; painful ulcers in the mouth and throat; difficulty swallowing
Root Cause:
Viral infection, most commonly caused by coxsackievirus A, leading to ulcerative lesions in the posterior oral cavity.
How it's Diagnosed: videos
Clinical examination based on characteristic oral lesions and history of fever.
Treatment:
Supportive care, including hydration, pain relief, and antipyretics.
Medications:
Analgesics like ibuprofen or acetaminophen ; topical anesthetics like viscous lidocaine for oral pain.
Prevalence:
How common the health condition is within a specific population.
Common in children under 10, especially during summer and early fall.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Young age, close contact in daycare or school settings.
Prognosis:
The expected outcome or course of the condition over time.
Excellent; resolves in 7-10 days with supportive care.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Rare but can include dehydration and febrile seizures.
Rhinocerebral Mucormycosis
Specialty: Infectious Diseases
Category: HEENT Infections
Symptoms:
nasal congestion; facial pain; fever; black necrotic tissue in the nasal cavity; vision loss
Root Cause:
Fungal infection caused by Mucorales species, often in immunocompromised individuals or those with diabetes.
How it's Diagnosed: videos
Histopathology and culture of tissue samples, supported by imaging (CT or MRI).
Treatment:
Aggressive surgical debridement and antifungal therapy.
Medications:
Antifungal agents such as amphotericin B and posaconazole .
Prevalence:
How common the health condition is within a specific population.
Rare, but more common in patients with diabetes, transplant recipients, or those receiving immunosuppressive therapy.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Uncontrolled diabetes, immunosuppression, trauma.
Prognosis:
The expected outcome or course of the condition over time.
Poor without prompt treatment; mortality rates exceed 50% in severe cases.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Spread to the brain, blindness, and death.
Viral Pharyngitis
Specialty: Infectious Diseases
Category: HEENT Infections
Symptoms:
sore throat; fever; cough; congestion; hoarseness; fatigue
Root Cause:
Inflammation of the pharynx caused by viral pathogens like rhinovirus, adenovirus, or Epstein-Barr virus.
How it's Diagnosed: videos
Based on clinical symptoms; throat swab to rule out bacterial infections.
Treatment:
Supportive care, including hydration, analgesics, and rest.
Medications:
Analgesics like ibuprofen or acetaminophen ; throat lozenges for symptom relief.
Prevalence:
How common the health condition is within a specific population.
Extremely common, especially during cold and flu seasons.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Close contact, crowded environments, weakened immune system.
Prognosis:
The expected outcome or course of the condition over time.
Excellent; symptoms resolve in 5-7 days with supportive care.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Rare but can include secondary bacterial infections or progression to lower respiratory tract infections.
Acute and Chronic Inflammatory Demyelinating Polyneuropathy in HIV
Specialty: Infectious Diseases
Category: Central Nervous System Complications in HIV
Symptoms:
progressive muscle weakness; loss of reflexes; tingling or numbness in extremities; difficulty walking; fatigue; autonomic dysfunction in severe cases
Root Cause:
Autoimmune-mediated damage to the myelin sheath of peripheral nerves, likely triggered by HIV-related immune dysregulation.
How it's Diagnosed: videos
Clinical examination, nerve conduction studies, cerebrospinal fluid (CSF) analysis (elevated protein levels with normal cell counts), and MRI to rule out other conditions.
Treatment:
Immunomodulatory therapies such as intravenous immunoglobulin (IVIG), plasmapheresis, and corticosteroids; antiretroviral therapy (ART) to control HIV infection.
Medications:
Treatments include corticosteroids (e.g., prednisone ), intravenous immunoglobulin (immunomodulatory agents), and ART (antiretroviral medications such as integrase inhibitors, protease inhibitors, and NNRTIs).
Prevalence:
How common the health condition is within a specific population.
Relatively rare; occurs in a small subset of HIV patients, typically those with advanced immunosuppression.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Advanced HIV infection, lack of adherence to ART, genetic predisposition to autoimmune responses.
Prognosis:
The expected outcome or course of the condition over time.
Variable; early diagnosis and treatment can lead to partial or full recovery, but delayed treatment may result in persistent neurological deficits.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic disability, progression to permanent nerve damage, or secondary infections due to weakened immune system.
Antiretroviral Therapy (ART) in Adolescents and Young Adults With HIV Infection
Specialty: Infectious Diseases
Category: HIV
Symptoms:
fatigue; fever; lymphadenopathy; weight loss; delayed growth or puberty; opportunistic infections
Root Cause:
Immune suppression due to HIV infection leading to vulnerability to infections and delayed development.
How it's Diagnosed: videos
HIV serology (ELISA and Western blot), CD4 count, HIV RNA viral load, and resistance testing.
Treatment:
Combination antiretroviral therapy (cART) tailored to age, weight, and resistance profiles. Regular counseling and adherence support are crucial.
Medications:
Dolutegravir-based regimens (integrase inhibitors), emtricitabine /tenofovir (reverse transcriptase inhibitors), abacavir /lamivudine (nucleoside reverse transcriptase inhibitors).
Prevalence:
How common the health condition is within a specific population.
Increasingly common with 1.8 million adolescents globally living with HIV.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Perinatal HIV transmission, early sexual activity, and poor adherence to ART.
Prognosis:
The expected outcome or course of the condition over time.
Good with early and consistent treatment; delayed treatment can lead to complications and lower life expectancy.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Drug resistance, delayed growth and development, social stigma, and mental health challenges.
Antiretroviral Therapy (ART) in Pregnant People With HIV Infection
Specialty: Infectious Diseases
Category: HIV
Symptoms:
asymptomatic in early stages; fatigue; opportunistic infections; frequent viral or bacterial infections
Root Cause:
Suppressed immune function due to HIV, with additional metabolic and hormonal challenges during pregnancy.
How it's Diagnosed: videos
HIV testing during pregnancy, CD4 count, HIV RNA viral load, and resistance testing.
Treatment:
ART to maintain maternal health and prevent vertical transmission, tailored for pregnancy. Delivery planning (e.g., cesarean section) may be part of care.
Medications:
Preferred regimens include dolutegravir (integrase inhibitors) and tenofovir disoproxil fumarate/emtricitabine or lamivudine (reverse transcriptase inhibitors). Avoid teratogenic drugs like efavirenz in the first trimester.
Prevalence:
How common the health condition is within a specific population.
Approximately 1.3 million women with HIV give birth annually worldwide.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Late diagnosis of HIV, poor adherence to ART, lack of prenatal care.
Prognosis:
The expected outcome or course of the condition over time.
Excellent for mother and child with proper care; without ART, up to 45% vertical transmission risk.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Preterm birth, low birth weight, stillbirth, neonatal HIV infection.
Antiretroviral Therapy (ART) in Treatment-Naive Patients With HIV Infection
Specialty: Infectious Diseases
Category: HIV
Symptoms:
fever; night sweats; weight loss; lymphadenopathy; diarrhea; opportunistic infections
Root Cause:
Progressive immune system destruction due to untreated HIV.
How it's Diagnosed: videos
HIV serology, baseline CD4 count, HIV RNA viral load, and drug resistance testing.
Treatment:
Immediate initiation of a combination ART regimen tailored to resistance profiles and patient tolerance.
Medications:
Bictegravir /tenofovir alafenamide /emtricitabine (integrase inhibitor + NRTIs), darunavir (protease inhibitor) combined with ritonavir or cobicistat .
Prevalence:
How common the health condition is within a specific population.
Globally, around 39 million people live with HIV; ART-naive prevalence varies by region.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Late diagnosis, lack of access to healthcare, and socioeconomic challenges.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with early ART; poor without treatment due to progression to AIDS and opportunistic infections.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Opportunistic infections, multi-organ failure, and death if untreated.
Antiretroviral Therapy for HIV Infection
Specialty: Infectious Diseases
Category: HIV
Symptoms:
asymptomatic in early stages; opportunistic infections in advanced stages; fatigue; lymphadenopathy
Root Cause:
Progressive loss of CD4 T cells due to HIV replication.
How it's Diagnosed: videos
Confirmatory HIV testing (ELISA, Western blot, PCR), CD4 count, viral load, and resistance testing.
Treatment:
Combination ART to suppress viral replication, restore immune function, and improve quality of life. Lifelong adherence is required.
Medications:
Integrase inhibitors (dolutegravir , bictegravir ), nucleoside reverse transcriptase inhibitors (tenofovir alafenamide , emtricitabine ), protease inhibitors (darunavir , atazanavir ).
Prevalence:
How common the health condition is within a specific population.
39 million people worldwide live with HIV; ART coverage is around 75% globally.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Unsafe sexual practices, intravenous drug use, untreated HIV.
Prognosis:
The expected outcome or course of the condition over time.
With consistent ART, life expectancy approaches that of uninfected individuals; without treatment, HIV progresses to AIDS within 8-10 years.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Cardiovascular disease, renal dysfunction, neurocognitive disorders, and drug resistance with poor adherence.
Central Nervous System Lymphoma in HIV
Specialty: Infectious Diseases
Category: Central Nervous System Complications in HIV
Symptoms:
headache; seizures; confusion; focal neurological deficits; behavioral changes; vision problems
Root Cause:
Epstein-Barr Virus (EBV)-associated malignancy that occurs due to severe immunosuppression in HIV patients, leading to unregulated B-cell proliferation.
How it's Diagnosed: videos
MRI or CT scan showing mass lesions, CSF cytology for malignant cells, and EBV DNA detection in CSF. Brain biopsy may be needed for definitive diagnosis.
Treatment:
High-dose methotrexate-based chemotherapy combined with ART; corticosteroids to reduce cerebral edema; radiation therapy in selected cases.
Medications:
High-dose methotrexate (antimetabolite chemotherapy), rituximab (monoclonal antibody), and corticosteroids such as dexamethasone (anti-inflammatory).
Prevalence:
How common the health condition is within a specific population.
Occurs in approximately 3–5% of HIV patients with advanced immunosuppression.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
CD4 count <50 cells/mm³, untreated or poorly controlled HIV, and EBV infection.
Prognosis:
The expected outcome or course of the condition over time.
Poor without treatment; survival improves with ART and aggressive lymphoma treatment but remains limited due to recurrence and systemic complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Intracranial pressure, seizures, cognitive impairment, and recurrence of lymphoma.
CNS Cryptococcosis in HIV
Specialty: Infectious Diseases
Category: Central Nervous System Complications in HIV
Symptoms:
headache; fever; nausea; vomiting; stiff neck; photophobia; altered mental status
Root Cause:
Opportunistic fungal infection caused by Cryptococcus neoformans or Cryptococcus gattii in immunocompromised individuals.
How it's Diagnosed: videos
CSF analysis with India ink staining, cryptococcal antigen test, fungal culture, and MRI/CT imaging for associated findings.
Treatment:
Initial treatment with amphotericin B and flucytosine for induction therapy, followed by fluconazole for consolidation and maintenance therapy; concurrent ART for HIV management.
Medications:
Amphotericin B (antifungal polyene), flucytosine (antifungal antimetabolite), fluconazole (azole antifungal).
Prevalence:
How common the health condition is within a specific population.
Common in HIV patients with CD4 counts <100 cells/mm³, particularly in resource-limited settings.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Advanced HIV, environmental exposure to cryptococcal spores, lack of ART adherence.
Prognosis:
The expected outcome or course of the condition over time.
High mortality if untreated; with prompt therapy, survival rates improve, though neurological sequelae may persist.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Increased intracranial pressure, hydrocephalus, and long-term cognitive deficits.
CNS Toxoplasmosis in HIV
Specialty: Infectious Diseases
Category: Central Nervous System Complications in HIV
Symptoms:
headache; seizures; confusion; fever; focal neurological deficits; lethargy
Root Cause:
Reactivation of latent infection by Toxoplasma gondii due to profound immunosuppression.
How it's Diagnosed: videos
Brain imaging (MRI or CT) showing ring-enhancing lesions, positive Toxoplasma serology (IgG), and CSF PCR for Toxoplasma gondii DNA.
Treatment:
Combination of pyrimethamine, sulfadiazine, and leucovorin; ART to restore immune function.
Medications:
Pyrimethamine (antiparasitic), sulfadiazine (antibiotic), leucovorin (folinic acid to reduce bone marrow toxicity).
Prevalence:
How common the health condition is within a specific population.
Occurs in 10–30% of HIV patients with CD4 counts <100 cells/mm³, especially in those not receiving prophylaxis.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Advanced HIV, exposure to Toxoplasma (e.g., undercooked meat, cat feces), and lack of prophylactic treatment.
Prognosis:
The expected outcome or course of the condition over time.
Good if treated early; untreated cases have high mortality. Residual neurological deficits may occur.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Persistent neurological deficits, seizures, or progression to coma in severe cases.
Common Drug Interactions with Protease Inhibitors
Specialty: Infectious Diseases
Category: Central Nervous System Complications in HIV
Symptoms:
unexpected drug toxicity; reduced efficacy of protease inhibitors; increased or decreased levels of co-administered medications
Root Cause:
Protease inhibitors interact with liver enzymes, particularly CYP450 enzymes, leading to altered drug metabolism.
How it's Diagnosed: videos
Clinical assessment of symptoms, medication review, and laboratory monitoring of drug levels.
Treatment:
Adjusting dosages, substituting conflicting medications, or switching to alternative regimens with fewer interactions.
Medications:
Adjustments may include avoiding medications metabolized by CYP3A4, prescribing ritonavir (used as a boosting agent), or using therapeutic drug monitoring (TDM).
Prevalence:
How common the health condition is within a specific population.
Common in HIV patients on protease inhibitor-based ART regimens; prevalence depends on specific regimens and co-administered drugs.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Polypharmacy, liver dysfunction, or use of over-the-counter drugs and supplements metabolized by the same enzymes.
Prognosis:
The expected outcome or course of the condition over time.
Generally manageable with appropriate monitoring and medication adjustments.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Suboptimal viral suppression, drug toxicity, or organ damage due to interactions.
Cutaneous Manifestations of HIV
Specialty: Infectious Diseases
Category: Dermatologic Complications of HIV
Symptoms:
rash; pruritus; papules; skin infections (e.g., fungal, bacterial); kaposi's sarcoma
Root Cause:
Immune dysfunction and opportunistic infections due to HIV.
How it's Diagnosed: videos
Clinical examination, biopsy of lesions, and testing for opportunistic infections.
Treatment:
Antiretroviral therapy (ART) to improve immune function, topical or systemic treatments for specific skin conditions.
Medications:
Treatments include antifungals (e.g., fluconazole ), antibacterials (e.g., mupirocin for bacterial skin infections), and antiviral agents for conditions like herpes.
Prevalence:
How common the health condition is within a specific population.
Affects approximately 40–80% of HIV patients at some point.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Advanced HIV stage, low CD4 count, poor ART adherence.
Prognosis:
The expected outcome or course of the condition over time.
Improves with effective ART and skin-directed therapies; prognosis depends on immune restoration.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Secondary infections, scarring, and progression of underlying opportunistic infections.
Cytomegalovirus Encephalitis in HIV
Specialty: Infectious Diseases
Category: Central Nervous System Complications in HIV
Symptoms:
headache; fever; cognitive impairment; seizures; vision changes
Root Cause:
Reactivation of latent cytomegalovirus (CMV) in the setting of severe immunosuppression.
How it's Diagnosed: videos
MRI or CT imaging, CSF analysis via lumbar puncture, and CMV PCR testing.
Treatment:
Antiviral therapy with ganciclovir or valganciclovir; immune restoration through ART.
Medications:
Ganciclovir and valganciclovir are antivirals that target CMV DNA polymerase. Foscarnet may be used in resistant cases.
Prevalence:
How common the health condition is within a specific population.
Occurs in 5–10% of untreated HIV/AIDS patients.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
CD4 count less than 50 cells/micro L, untreated HIV, prior CMV infection.
Prognosis:
The expected outcome or course of the condition over time.
Poor if untreated; significant improvement with early diagnosis and therapy.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Permanent cognitive deficits, vision loss, or death.
Drug Interactions with Antiretroviral Therapy (ART)
Specialty: Infectious Diseases
Category: Medication-Related Complications in HIV
Symptoms:
therapeutic failure of art; drug toxicity; unexpected adverse effects
Root Cause:
ART interacts with other medications via cytochrome P450 enzymes, transporters like P-glycoprotein, or through additive toxicities.
How it's Diagnosed: videos
Comprehensive medication review and clinical monitoring of drug efficacy and side effects.
Treatment:
Medication reconciliation, dose adjustments, or switching medications to reduce interactions.
Medications:
Interventions include using alternative ART regimens or prescribing agents to counteract interaction effects (e.g., boosters like cobicistat ).
Prevalence:
How common the health condition is within a specific population.
Common in HIV patients due to the widespread use of polypharmacy.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Polypharmacy, comorbid conditions, and inconsistent follow-up care.
Prognosis:
The expected outcome or course of the condition over time.
Good with proper management; untreated interactions may lead to ART failure or toxicity.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
HIV progression, organ damage, or resistance development.
Early Symptomatic HIV Infection
Specialty: Infectious Diseases
Category: Early HIV Complications
Symptoms:
fever; fatigue; night sweats; weight loss; diarrhea; lymphadenopathy
Root Cause:
Rapid viral replication and immune activation during the initial stages of HIV infection.
How it's Diagnosed: videos
HIV antibody and antigen testing, CD4 count, and viral load.
Treatment:
Initiation of combination ART as soon as possible.
Medications:
ART includes nucleoside reverse transcriptase inhibitors (e.g., tenofovir ), non-nucleoside reverse transcriptase inhibitors (e.g., efavirenz ), and protease inhibitors (e.g., darunavir ).
Prevalence:
How common the health condition is within a specific population.
Affects most individuals newly diagnosed with HIV.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
High viral load, untreated HIV infection, lack of preventative care.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with early ART; without treatment, rapid progression to AIDS is possible.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Persistent immune dysfunction, opportunistic infections, or progression to AIDS.
Hairy Leukoplakia
Specialty: Infectious Diseases
Category: Oral Manifestations of HIV
Symptoms:
white, corrugated patches on the lateral tongue; painless lesions; difficulty swallowing (rare)
Root Cause:
Epstein-Barr virus (EBV) infection in the setting of immunosuppression.
How it's Diagnosed: videos
Clinical examination and biopsy of lesions. EBV DNA testing may confirm diagnosis.
Treatment:
Antiviral therapy is not always necessary; ART is the primary treatment to restore immune function.
Medications:
High-dose acyclovir or valacyclovir (antivirals) may be used for severe or persistent cases.
Prevalence:
How common the health condition is within a specific population.
Occurs in up to 25% of HIV patients with CD4 counts below 200 cells/micro L.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Advanced HIV, immunosuppression, poor oral hygiene.
Prognosis:
The expected outcome or course of the condition over time.
Resolves with effective ART; not usually life-threatening.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Cosmetic concerns and potential secondary infections.
HIV Infection and AIDS
Specialty: Infectious Diseases
Category: HIV and Nutrition
Symptoms:
fever; fatigue; weight loss; recurrent infections; diarrhea; opportunistic infections
Root Cause:
Progressive failure of the immune system caused by the human immunodeficiency virus (HIV), leading to opportunistic infections and AIDS in advanced stages.
How it's Diagnosed: videos
HIV antibody/antigen tests, CD4+ T-cell count, viral load testing, and clinical evaluation.
Treatment:
Antiretroviral therapy (ART) using a combination of drugs, supportive care, and treatment of opportunistic infections.
Medications:
ART includes classes like NRTIs (e.g., tenofovir , lamivudine ), NNRTIs (e.g., efavirenz ), protease inhibitors (e.g., darunavir ), and integrase inhibitors (e.g., dolutegravir ).
Prevalence:
How common the health condition is within a specific population.
Affects approximately 38 million people worldwide as of 2023.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Unprotected sexual activity, intravenous drug use, blood transfusions, and vertical transmission from mother to child.
Prognosis:
The expected outcome or course of the condition over time.
Improved significantly with ART; life expectancy approaches normal with early and consistent treatment.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Opportunistic infections, malignancies, neurocognitive disorders, and chronic conditions like cardiovascular disease.
HIV-Associated Distal Painful Sensorimotor Polyneuropathy
Specialty: Infectious Diseases
Category: HIV and Nutrition
Symptoms:
pain and burning sensations in the feet and hands; numbness; tingling; loss of reflexes; muscle weakness
Root Cause:
Damage to peripheral nerves caused by direct HIV infection, immune-mediated mechanisms, or antiretroviral therapy (e.g., dideoxynucleoside analogs).
How it's Diagnosed: videos
Clinical examination, history of HIV infection, nerve conduction studies, electromyography (EMG), and exclusion of other causes of neuropathy.
Treatment:
Pain management, discontinuation of offending antiretroviral drugs if applicable, physical therapy, and addressing nutritional deficiencies.
Medications:
Medications include anticonvulsants such as gabapentin or pregabalin , antidepressants like amitriptyline or duloxetine , and topical agents like capsaicin cream. Pain relief may also involve opioids in severe cases.
Prevalence:
How common the health condition is within a specific population.
Affects approximately 30%-60% of people living with HIV, particularly in advanced stages of the disease.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Advanced HIV infection, use of neurotoxic antiretroviral drugs, poor nutritional status, diabetes, and alcohol use.
Prognosis:
The expected outcome or course of the condition over time.
Symptoms may persist despite treatment, but early intervention can reduce severity and improve quality of life. Progression depends on HIV management and associated comorbidities.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic pain, decreased mobility, falls, and diminished quality of life.
HIV-Associated Multiple Mononeuropathies
Specialty: Infectious Diseases
Category: HIV and Neurology
Symptoms:
asymmetric weakness; pain; sensory loss in affected nerve distributions
Root Cause:
Multifocal involvement of peripheral nerves due to HIV-induced immune dysfunction or opportunistic infections.
How it's Diagnosed: videos
Neurological examination, nerve conduction studies, EMG, and exclusion of alternative causes like vasculitis or diabetes.
Treatment:
Antiretroviral therapy (ART), management of opportunistic infections, and symptomatic pain control.
Medications:
Immunosuppressants (if immune-mediated), pain medications (gabapentin , amitriptyline ), and ART adjustments.
Prevalence:
How common the health condition is within a specific population.
Less common than distal symmetric neuropathy; primarily observed in advanced HIV stages.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Advanced HIV, coinfections, and untreated immune dysfunction.
Prognosis:
The expected outcome or course of the condition over time.
Recovery depends on early detection and treatment; untreated cases may lead to significant disability.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Permanent nerve damage and functional impairment.
HIV-Associated Neurocognitive Disorder (HAND)
Specialty: Infectious Diseases
Category: HIV and Neurology
Symptoms:
memory impairment; difficulty concentrating; slowed mental processing; behavioral changes; motor dysfunction
Root Cause:
Direct viral effects, chronic immune activation, and inflammation in the central nervous system due to HIV infection.
How it's Diagnosed: videos
Neuropsychological testing, MRI or CT to rule out other causes, and clinical assessment of cognitive and functional impairment.
Treatment:
Effective ART, cognitive rehabilitation, and management of contributing factors like depression and substance use.
Medications:
Antiretrovirals with good CNS penetration (e.g., efavirenz or dolutegravir ) and adjunctive medications for symptomatic management, such as antidepressants or psychostimulants.
Prevalence:
How common the health condition is within a specific population.
Affects approximately 15%-50% of people living with HIV, depending on disease stage and ART status.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Low CD4 count, high viral load, aging, co-infections, and substance abuse.
Prognosis:
The expected outcome or course of the condition over time.
Variable; early ART initiation improves outcomes, but cognitive deficits may persist in some cases.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Progression to dementia, reduced quality of life, and functional dependency.
HIV-Associated Vacuolar Myelopathy
Specialty: Infectious Diseases
Category: HIV and Neurology
Symptoms:
progressive leg weakness; spasticity; numbness or tingling in the lower limbs; difficulty walking; bladder dysfunction
Root Cause:
Spinal cord degeneration caused by chronic HIV infection and inflammation, leading to vacuolar changes in the white matter.
How it's Diagnosed: videos
Clinical examination, spinal MRI, and exclusion of other causes such as vitamin B12 deficiency or syphilis.
Treatment:
ART to control HIV, physical therapy for mobility issues, and symptomatic management of spasticity or bladder dysfunction.
Medications:
Antispasmodics (e.g., baclofen or tizanidine ) for spasticity and antiretrovirals for the underlying condition.
Prevalence:
How common the health condition is within a specific population.
Occurs in up to 10% of untreated individuals with advanced HIV.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Advanced HIV, poor ART adherence, and low CD4 count.
Prognosis:
The expected outcome or course of the condition over time.
Progressive but may stabilize with effective ART; mobility can be significantly impacted.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Paraplegia, incontinence, and reduced quality of life.
Neuromuscular and Myopathic Complications of HIV
Specialty: Infectious Diseases
Category: HIV and Nutrition
Symptoms:
muscle weakness; muscle pain; fatigue; difficulty with coordination; neuropathy such as numbness or tingling in extremities
Root Cause:
Damage to muscles or nerves caused by direct HIV effects, chronic inflammation, opportunistic infections, or side effects of antiretroviral therapy (ART).
How it's Diagnosed: videos
Clinical evaluation, electromyography (EMG), nerve conduction studies, muscle biopsy, and blood tests for creatine kinase levels.
Treatment:
Management of underlying HIV infection with optimized ART, physical therapy, and treatment of specific complications like opportunistic infections or drug-induced myopathy.
Medications:
Medications may include antiretroviral drugs to control HIV (e.g., integrase inhibitors, protease inhibitors), corticosteroids for inflammatory conditions, and neuropathic pain medications such as gabapentin or pregabalin . Muscle relaxants or NSAIDs may be prescribed for pain.
Prevalence:
How common the health condition is within a specific population.
Neuromuscular complications occur in up to 15-25% of HIV patients, depending on disease progression and treatment adherence.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Advanced HIV, poor adherence to ART, opportunistic infections, certain ART regimens (e.g., zidovudine-associated myopathy), nutritional deficiencies.
Prognosis:
The expected outcome or course of the condition over time.
With effective ART, prognosis improves significantly; however, some complications may lead to persistent symptoms or long-term disability if not managed promptly.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic pain, permanent muscle weakness, disability, increased risk of falls or injuries, and diminished quality of life.
Ocular Manifestations of HIV Infection
Specialty: Infectious Diseases
Category: HIV and Vision
Symptoms:
blurred vision; floaters; pain or redness in the eye; vision loss; light sensitivity; double vision
Root Cause:
Direct HIV effects, opportunistic infections (e.g., cytomegalovirus retinitis), or immune recovery uveitis causing inflammation or damage to the eye structures.
How it's Diagnosed: videos
Comprehensive eye examination, including dilated fundoscopic examination, optical coherence tomography (OCT), and imaging studies. Laboratory tests to confirm opportunistic infections.
Treatment:
Treatment depends on the cause, including ART for HIV control, antiviral medications for infections (e.g., ganciclovir for CMV), corticosteroids for inflammation, and laser therapy for retinal detachment.
Medications:
Ganciclovir (antiviral) for CMV retinitis, valganciclovir (oral antiviral), and corticosteroid eye drops for immune-mediated inflammation.
Prevalence:
How common the health condition is within a specific population.
Up to 50% of untreated HIV patients experience ocular complications, though rates are lower with effective ART.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Advanced HIV, low CD4 counts, untreated opportunistic infections, and lack of access to ART.
Prognosis:
The expected outcome or course of the condition over time.
Effective ART reduces incidence; prompt diagnosis and treatment of infections improve outcomes, though some complications may lead to permanent vision loss.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Permanent vision impairment, blindness, retinal detachment, and decreased quality of life.
Pediatric HIV Infection
Specialty: Infectious Diseases
Category: HIV in Pediatrics
Symptoms:
failure to thrive; recurrent infections; developmental delays; chronic diarrhea; lymphadenopathy; fever
Root Cause:
Transmission of HIV from mother to child during pregnancy, delivery, or breastfeeding, leading to immune suppression and vulnerability to infections.
How it's Diagnosed: videos
HIV nucleic acid tests (DNA or RNA) in infants younger than 18 months; HIV antibody testing in older children.
Treatment:
Early initiation of ART, prophylaxis for opportunistic infections, and supportive care including nutritional supplementation.
Medications:
Pediatric formulations of ART drugs such as lamivudine , abacavir , and lopinavir /ritonavir . Prophylactic trimethoprim-sulfamethoxazole for Pneumocystis pneumonia.
Prevalence:
How common the health condition is within a specific population.
Estimated 1.7 million children globally live with HIV; most cases are in sub-Saharan Africa.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Maternal HIV infection, lack of access to perinatal ART, breastfeeding by an untreated HIV-positive mother.
Prognosis:
The expected outcome or course of the condition over time.
With early and effective ART, children can achieve near-normal life expectancy; delayed diagnosis increases morbidity and mortality.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Opportunistic infections, growth failure, neurocognitive impairments, and psychosocial challenges.
Progressive Multifocal Leukoencephalopathy (PML) in HIV
Specialty: Infectious Diseases
Category: Neurological Complications of HIV
Sub-category: Demyelinating Disorders
Symptoms:
progressive weakness; visual disturbances; difficulty speaking; cognitive decline; ataxia; seizures
Root Cause:
Reactivation of JC virus in the central nervous system due to immunosuppression, leading to demyelination of nerve cells.
How it's Diagnosed: videos
MRI brain imaging showing white matter lesions, CSF analysis for JC virus DNA via PCR, and clinical evaluation.
Treatment:
Initiation or optimization of ART to restore immune function, and supportive care to manage neurological symptoms.
Medications:
No direct antiviral treatment for JC virus; management focuses on restoring immune function with ART. Investigational therapies include immune checkpoint inhibitors or antiviral agents like brincidofovir (investigational).
Prevalence:
How common the health condition is within a specific population.
Occurs in 1-5% of HIV-positive individuals, more common in those with advanced immunosuppression (CD4 < 200 cells/mm³).
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Advanced HIV, low CD4 count, prior opportunistic infections, and suboptimal ART adherence.
Prognosis:
The expected outcome or course of the condition over time.
Guarded; survival has improved with ART, but residual neurological deficits are common.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Severe neurological disability, seizures, and increased mortality.
Progressive Polyradiculopathy in HIV
Specialty: Infectious Diseases
Category: Neurological Complications of HIV
Sub-category: Peripheral Neuropathies
Symptoms:
progressive weakness in lower limbs; loss of reflexes; urinary retention; paresthesia; back pain
Root Cause:
Inflammation and damage to nerve roots, often due to cytomegalovirus (CMV) infection in severely immunosuppressed HIV patients.
How it's Diagnosed: videos
MRI or CT myelography of the spinal cord, CSF analysis showing CMV DNA, and electrophysiological studies.
Treatment:
Initiation or optimization of ART and specific antiviral therapy for CMV (e.g., ganciclovir or foscarnet).
Medications:
Ganciclovir (antiviral) or foscarnet (antiviral) for CMV, combined with ART to address HIV.
Prevalence:
How common the health condition is within a specific population.
Rare; occurs in advanced HIV/AIDS with severe immunosuppression.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
CD4 count < 50 cells/mm³, untreated HIV, and co-infections with CMV or other opportunistic pathogens.
Prognosis:
The expected outcome or course of the condition over time.
Depends on timely diagnosis and treatment; significant neurological recovery is possible with early intervention.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic neurological deficits, bladder dysfunction, and reduced mobility.
Aspiration Pneumonitis and Pneumonia
Specialty: Infectious Diseases
Category: Lower Respiratory Tract Infections
Symptoms:
cough; fever; dyspnea (shortness of breath); chest pain; wheezing; fatigue; sputum production
Root Cause:
Inhalation of gastric contents, oral secretions, or foreign materials into the lower respiratory tract, causing inflammation or infection.
How it's Diagnosed: videos
Clinical history of aspiration, imaging (chest X-ray, CT scan showing infiltrates in dependent lung areas), sputum culture, and bronchoscopy if necessary.
Treatment:
Supportive care, antibiotics for infection, oxygen therapy, mechanical ventilation if severe. Prevention through swallowing rehabilitation or feeding tube placement if indicated.
Medications:
Antibiotics such as clindamycin (lincosamide antibiotic), ampicillin-sulbactam (penicillin combination), or metronidazole (nitroimidazole antibiotic) in combination with other agents to cover anaerobic and aerobic bacteria.
Prevalence:
How common the health condition is within a specific population.
More common in hospitalized patients, particularly in those with dysphagia, neurological disorders, or altered mental status.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Advanced age, impaired swallowing, altered consciousness, alcohol abuse, GERD, and prolonged immobility.
Prognosis:
The expected outcome or course of the condition over time.
Varies; aspiration pneumonitis often resolves with supportive care, while pneumonia may lead to complications without appropriate treatment.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Lung abscess, respiratory failure, sepsis, or chronic aspiration leading to pulmonary fibrosis.
Chlamydial Pneumonias
Specialty: Infectious Diseases
Category: Lower Respiratory Tract Infections
Symptoms:
persistent dry cough; low-grade fever; mild fatigue; pharyngitis; wheezing; shortness of breath
Root Cause:
Infection caused by Chlamydia pneumoniae or Chlamydia psittaci, leading to atypical pneumonia.
How it's Diagnosed: videos
Serologic testing, polymerase chain reaction (PCR), and culture of respiratory secretions.
Treatment:
Antibiotics targeting atypical organisms, supportive care, and management of symptoms.
Medications:
Macrolides like azithromycin or clarithromycin , tetracyclines such as doxycycline , or fluoroquinolones like levofloxacin . These antibiotics target the intracellular lifecycle of Chlamydia.
Prevalence:
How common the health condition is within a specific population.
Accounts for about 5–15% of community-acquired pneumonia cases.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Close contact with infected individuals, immunosuppression, smoking, and exposure to birds in the case of C. psittaci.
Prognosis:
The expected outcome or course of the condition over time.
Generally favorable with prompt treatment; severe cases can occur in older or immunocompromised patients.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Respiratory failure, chronic lung disease, or systemic spread in immunocompromised individuals.
Community-Acquired Pneumonia Empiric Therapy
Specialty: Infectious Diseases
Category: Lower Respiratory Tract Infections
Symptoms:
fever; productive or dry cough; shortness of breath; pleuritic chest pain; chills; malaise
Root Cause:
Suspected bacterial or atypical pathogen causing pneumonia before specific pathogen identification is available.
How it's Diagnosed: videos
Empiric therapy is initiated based on clinical presentation, radiographic findings, and severity assessment tools like CURB-65 or PSI scores.
Treatment:
Antibiotics targeting common pathogens (Streptococcus pneumoniae, Haemophilus influenzae, atypical organisms like Mycoplasma pneumoniae). Therapy is tailored to patient risk factors and severity of illness.
Medications:
Outpatient cases
Prevalence:
How common the health condition is within a specific population.
Empiric therapy guidelines apply universally in managing CAP; up to 10% of cases require hospitalization.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Advanced age, chronic diseases, immunosuppression, prior antibiotic use, and recent healthcare exposure.
Prognosis:
The expected outcome or course of the condition over time.
Favorable in most cases; early treatment reduces morbidity and mortality. Severe or misdiagnosed cases may have a higher risk of complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Development of antibiotic resistance, incomplete pathogen coverage leading to clinical deterioration, or adverse drug reactions.
Community-Acquired Pneumonia Organism-Specific Therapy
Specialty: Infectious Diseases
Category: Lower Respiratory Tract Infections
Symptoms:
symptoms vary by pathogen; fever; cough; dyspnea; chest pain; chills
Root Cause:
Tailored treatment based on the identified causative organism of CAP, ensuring pathogen-directed therapy for optimal outcomes.
How it's Diagnosed: videos
Specific pathogen detection via blood culture, sputum culture, PCR, urine antigen tests (e.g., for Legionella or Streptococcus pneumoniae).
Treatment:
Antibiotic regimen refined based on culture and sensitivity results, considering pathogen resistance patterns.
Medications:
Streptococcus pneumoniae - Beta-lactams like amoxicillin or ceftriaxone . Haemophilus influenzae - Amoxicillin-clavulanate or cefuroxime . Mycoplasma pneumoniae or Chlamydia pneumoniae - Macrolides (e.g., azithromycin ) or doxycycline . Legionella pneumophila - Fluoroquinolones (e.g., levofloxacin ) or macrolides. Methicillin-resistant Staphylococcus aureus (MRSA) - Vancomycin or linezolid .
Prevalence:
How common the health condition is within a specific population.
Organism-specific therapy is applied after pathogen identification, which occurs in up to 30–40% of CAP cases.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Pathogen exposure, prior hospitalizations, travel, or animal contact.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with pathogen-directed therapy; delays in pathogen identification may worsen outcomes.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Progression to respiratory failure, sepsis, or organ dysfunction if treatment is delayed or ineffective.
Coronavirus Disease 2019 (COVID-19)
Specialty: Infectious Diseases
Category: Lower Respiratory Tract Infections
Symptoms:
fever; cough; shortness of breath; fatigue; loss of taste or smell; muscle aches; sore throat; headache; congestion or runny nose; nausea or vomiting; diarrhea
Root Cause:
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causing inflammation, immune response dysregulation, and damage to lung and other organ tissues.
How it's Diagnosed: videos
Diagnosis is made through a combination of clinical symptoms, polymerase chain reaction (PCR) testing for SARS-CoV-2 RNA, antigen tests, chest imaging (e.g., chest X-rays or CT scans showing ground-glass opacities), and blood tests indicating inflammation or coagulopathy.
Treatment:
Treatment focuses on managing symptoms, preventing complications, and supporting organ function. Includes antiviral medications, corticosteroids, anticoagulation therapy, and supportive care (e.g., oxygen therapy, mechanical ventilation if needed). Vaccination and post-exposure prophylaxis are also key preventive measures.
Medications:
Antiviral medications - Remdesivir (nucleotide analog), Paxlovid (combination of nirmatrelvir and ritonavir ), and molnupiravir (nucleoside analog). Corticosteroids - Dexamethasone is used to reduce inflammation in severe cases. Anticoagulants - Low-molecular-weight heparin or direct oral anticoagulants (DOACs) to prevent thromboembolism. Immunomodulators - Tocilizumab (IL-6 receptor antagonist) or baricitinib (JAK inhibitor) in severe inflammatory cases.
Prevalence:
How common the health condition is within a specific population.
A global pandemic affecting hundreds of millions of people since its emergence in late 2019. Prevalence varies by region, vaccination rates, and public health measures.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Older age, comorbidities such as hypertension, diabetes, cardiovascular disease, obesity, immunosuppression, and being unvaccinated or undervaccinated.
Prognosis:
The expected outcome or course of the condition over time.
The majority of cases are mild to moderate, with recovery expected in a few weeks. Severe or critical cases can lead to long-term complications or death. Prognosis is improved with early diagnosis, appropriate treatment, and vaccination.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Acute respiratory distress syndrome (ARDS), thromboembolic events (e.g., pulmonary embolism, deep vein thrombosis), myocarditis, long COVID (persistent symptoms lasting weeks to months), kidney injury, neurological complications, and secondary infections.
Fungal Pneumonia
Specialty: Infectious Diseases
Category: Lower Respiratory Tract Infections
Symptoms:
cough (sometimes with blood); fever; chest pain; shortness of breath; fatigue; night sweats
Root Cause:
Infection of the lungs caused by fungal organisms, such as Aspergillus, Histoplasma capsulatum, or Coccidioides. These fungi typically enter through inhalation of spores.
How it's Diagnosed: videos
Clinical evaluation, imaging (chest X-rays or CT scans), fungal cultures, antigen or antibody blood tests, and histopathological examination.
Treatment:
Antifungal medications, supportive care (oxygen therapy if needed), and addressing underlying immunosuppressive conditions.
Medications:
Antifungals such as fluconazole (azole class), amphotericin B (polyene class), or itraconazole (azole class).
Prevalence:
How common the health condition is within a specific population.
Relatively rare, with higher prevalence in immunocompromised individuals or those living in endemic areas.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Immunosuppression (e.g., HIV, chemotherapy), residing in or visiting endemic areas, long-term corticosteroid use, or organ transplantation.
Prognosis:
The expected outcome or course of the condition over time.
Favorable with timely treatment, but delayed or untreated cases may lead to severe complications or death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Respiratory failure, dissemination to other organs, and secondary bacterial infections.
Hantavirus Pulmonary Syndrome
Specialty: Infectious Diseases
Category: Viral Lower Respiratory Tract Infections
Symptoms:
fever; muscle aches; headache; cough; difficulty breathing; rapidly progressive respiratory failure
Root Cause:
Severe viral infection caused by hantavirus, transmitted through inhalation of aerosolized rodent urine, feces, or saliva.
How it's Diagnosed: videos
Serology for hantavirus antibodies, reverse transcription PCR, clinical history of rodent exposure, and imaging studies showing pulmonary edema.
Treatment:
Supportive care, including mechanical ventilation for respiratory distress and fluid management.
Medications:
No specific antiviral medications; ribavirin is being studied for potential use in some cases.
Prevalence:
How common the health condition is within a specific population.
Rare, primarily in rural areas of the Americas with exposure to rodent habitats.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Exposure to rodent droppings, occupational risks (e.g., farming, construction), and camping or hiking in endemic regions.
Prognosis:
The expected outcome or course of the condition over time.
Mortality rate is around 35-50%; early supportive care improves outcomes.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Respiratory failure, hypotensive shock, and multi-organ failure.
Hospital-Acquired Pneumonia (HAP) and Ventilator-Associated Event (VAE) Empiric Therapy
Specialty: Infectious Diseases
Category: Nosocomial Infections
Symptoms:
fever; increased respiratory secretions; new or worsening infiltrates on chest x-rays; cough; shortness of breath; elevated white blood cell count
Root Cause:
Infections caused by multidrug-resistant pathogens such as Pseudomonas aeruginosa, Acinetobacter, or MRSA due to prolonged hospital stay or mechanical ventilation.
How it's Diagnosed: videos
Clinical suspicion, imaging studies, and microbiological culture from respiratory secretions.
Treatment:
Empiric broad-spectrum antibiotics based on local antibiograms, later narrowed by culture results.
Medications:
Piperacillin-tazobactam (beta-lactam), vancomycin (glycopeptide), or meropenem (carbapenem).
Prevalence:
How common the health condition is within a specific population.
Common nosocomial infection, especially in ICU settings; incidence is approximately 5-15% among intubated patients.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Mechanical ventilation, prolonged hospitalization, immunosuppression, prior antibiotic use, and invasive procedures.
Prognosis:
The expected outcome or course of the condition over time.
Varies based on pathogen and promptness of treatment; higher mortality rates in multidrug-resistant infections.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Septic shock, acute respiratory distress syndrome (ARDS), and prolonged hospitalization.
Hospital-Acquired Pneumonia (Nosocomial Pneumonia) and Ventilator-Associated Pneumonia
Specialty: Infectious Diseases
Category: Nosocomial Infections
Symptoms:
fever; increased or purulent respiratory secretions; dyspnea; cough; lung infiltrates on imaging; hypoxemia
Root Cause:
Infections caused by bacterial pathogens, including Klebsiella pneumoniae, Escherichia coli, or Staphylococcus aureus, often due to prolonged intubation or inadequate sterile procedures.
How it's Diagnosed: videos
Clinical presentation, microbiological analysis of respiratory samples, imaging, and clinical scoring systems (e.g., CPIS).
Treatment:
Targeted antibiotic therapy based on culture results and supportive care.
Medications:
Linezolid (oxazolidinone), ceftazidime-avibactam (beta-lactam), or tobramycin (aminoglycoside).
Prevalence:
How common the health condition is within a specific population.
Among the most common hospital-acquired infections; approximately 25% of ICU patients on ventilators are affected.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Prolonged mechanical ventilation, sedation, immobility, poor oral hygiene, and broad-spectrum antibiotic use.
Prognosis:
The expected outcome or course of the condition over time.
Mortality rates vary but can exceed 30% in severe cases; timely and effective treatment improves outcomes.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Sepsis, organ failure, prolonged ICU stay, and resistance to multiple antibiotics.
Hospital-Acquired, Health Care-Associated, and Ventilator-Associated Pneumonia Organism-Specific Therapy
Specialty: Infectious Diseases
Category: Nosocomial Infections
Symptoms:
persistent fever; worsening respiratory function; cough with discolored sputum; pleuritic chest pain; respiratory distress
Root Cause:
Targeted infection management based on specific pathogens, such as MRSA, Pseudomonas aeruginosa, or Acinetobacter baumannii.
How it's Diagnosed: videos
Microbiological identification of causative organism via sputum or bronchoalveolar lavage cultures.
Treatment:
Narrow-spectrum antibiotics based on susceptibility patterns; escalation or de-escalation as needed.
Medications:
Ceftaroline (cephalosporin), colistin (polymyxins), or imipenem-cilastatin (carbapenem).
Prevalence:
How common the health condition is within a specific population.
Variable depending on institutional practices; most prevalent in ICU settings.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Invasive medical devices, immunocompromised state, long hospital stays, and resistance patterns of local flora.
Prognosis:
The expected outcome or course of the condition over time.
Pathogen-specific; multidrug-resistant organisms worsen outcomes.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Respiratory failure, systemic infections, abscess formation, and prolonged need for ventilatory support.
Human Metapneumovirus
Specialty: Infectious Diseases
Category: Viral Lower Respiratory Tract Infections
Symptoms:
cough; runny nose; fever; sore throat; shortness of breath; wheezing
Root Cause:
Viral infection of the respiratory tract caused by human metapneumovirus, particularly affecting children, the elderly, and immunocompromised individuals.
How it's Diagnosed: videos
PCR testing of nasal or throat swabs, viral cultures, or serological testing for specific antibodies.
Treatment:
Supportive care, including hydration, antipyretics, and oxygen therapy for severe cases.
Medications:
No specific antiviral therapy; ribavirin has been studied in severe cases, but its use is not standardized.
Prevalence:
How common the health condition is within a specific population.
Common cause of respiratory infections, particularly in winter and spring; contributes to 5-10% of pediatric hospitalizations for acute respiratory illness.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Age extremes, daycare or school exposure, chronic respiratory or cardiovascular diseases, and immunosuppression.
Prognosis:
The expected outcome or course of the condition over time.
Generally good, with most cases resolving spontaneously; severe outcomes possible in high-risk groups.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Bronchiolitis, pneumonia, acute respiratory distress syndrome, and secondary bacterial infections.
Legionnaires' Disease
Specialty: Infectious Diseases
Category: Lower Respiratory Tract Infections
Symptoms:
high fever; chills; cough (productive or dry); shortness of breath; muscle aches; headache; diarrhea; nausea; confusion or mental changes in severe cases
Root Cause:
Caused by infection with Legionella bacteria, commonly Legionella pneumophila. Infection occurs through inhalation of aerosolized water droplets contaminated with the bacteria.
How it's Diagnosed: videos
Diagnosis involves chest X-rays to detect pneumonia, urine antigen tests for Legionella species, sputum culture, and PCR tests. Blood tests may show abnormalities indicating infection.
Treatment:
Treated primarily with antibiotics that target Legionella, supportive care for symptoms such as oxygen therapy for breathing difficulties, and hydration for fluid balance.
Medications:
Antibiotics - Fluoroquinolones (e.g., levofloxacin , ciprofloxacin ), macrolides (e.g., azithromycin ), or tetracyclines (e.g., doxycycline ) are commonly prescribed. These are bactericidal or bacteriostatic medications effective against Legionella.
Prevalence:
How common the health condition is within a specific population.
Infrequent but can occur sporadically or in outbreaks, especially in settings with poorly maintained water systems. Affects approximately 1-2 cases per 100,000 people annually in the U.S.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Age over 50, smoking, chronic lung disease, weakened immune system, history of recent travel (hotels or cruise ships with poor water system maintenance).
Prognosis:
The expected outcome or course of the condition over time.
Early treatment with antibiotics results in recovery in most cases; however, severe cases, particularly in immunocompromised individuals, may lead to complications and higher mortality rates (10-15%).
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Respiratory failure, septic shock, multi-organ failure, long-term lung scarring, and secondary bacterial infections.
Middle East Respiratory Syndrome (MERS)
Specialty: Infectious Diseases
Category: Lower Respiratory Tract Infections
Symptoms:
fever; cough; shortness of breath; muscle pain; nausea; vomiting; diarrhea; abdominal pain
Root Cause:
Caused by the MERS-CoV coronavirus, transmitted through respiratory droplets or contact with infected individuals or camels. Severe cases involve acute respiratory distress syndrome (ARDS).
How it's Diagnosed: videos
Diagnosis is based on PCR testing for MERS-CoV in respiratory samples, chest imaging to detect pneumonia or ARDS, and serologic tests.
Treatment:
Supportive care, including oxygen therapy, mechanical ventilation in severe cases, and treatment of secondary infections. No specific antiviral therapy is widely accepted.
Medications:
Experimental - Antivirals (e.g., ribavirin ) combined with interferon have been investigated but are not standard treatments. Supportive medications - Antipyretics for fever, and bronchodilators for respiratory relief.
Prevalence:
How common the health condition is within a specific population.
Outbreaks have primarily occurred in the Middle East. Limited cases in other regions due to travel-associated spread. Mortality rates range from 30-40%.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Close contact with camels, healthcare exposure to infected individuals, age over 50, pre-existing chronic diseases (e.g., diabetes, heart disease).
Prognosis:
The expected outcome or course of the condition over time.
Severe cases can progress to multi-organ failure and death, particularly in high-risk groups. Mild cases may resolve with symptomatic management.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
ARDS, septic shock, renal failure, and long-term pulmonary complications in survivors.
Nursing Home Acquired Pneumonia (NHAP)
Specialty: Infectious Diseases
Category: Lower Respiratory Tract Infections
Symptoms:
cough; fever; shortness of breath; chest pain; confusion or altered mental status in elderly patients; fatigue; weakness
Root Cause:
Pneumonia occurring in nursing home residents due to increased exposure to pathogens, aspiration, and weakened immune defenses. Common causative agents include Streptococcus pneumoniae, Klebsiella pneumoniae, and Pseudomonas aeruginosa.
How it's Diagnosed: videos
Clinical examination, chest X-ray showing infiltrates, sputum culture, blood tests indicating infection (elevated white blood cell count, CRP), and pulse oximetry to assess oxygen levels.
Treatment:
Empirical antibiotic therapy tailored to likely pathogens, oxygen supplementation, hydration, and management of comorbidities.
Medications:
Antibiotics - Beta-lactams (e.g., ceftriaxone ), macrolides (e.g., azithromycin ), or fluoroquinolones (e.g., levofloxacin ). These are selected based on the patient’s condition and local antimicrobial resistance patterns. Supportive medications - Antipyretics for fever and bronchodilators for airway relief.
Prevalence:
How common the health condition is within a specific population.
One of the most common infections in nursing home residents, with a significant impact on morbidity and mortality in this population.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Advanced age, immobility, chronic diseases (e.g., diabetes, COPD), malnutrition, aspiration, and use of feeding tubes.
Prognosis:
The expected outcome or course of the condition over time.
Prognosis varies based on promptness of treatment, severity of pneumonia, and the patient’s underlying health. Mortality rates range from 10-30%.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Respiratory failure, sepsis, empyema, and exacerbation of chronic conditions.
Pneumococcal Infections (Streptococcus pneumoniae)
Specialty: Infectious Diseases
Category: Lower Respiratory Tract Infections
Symptoms:
fever; chills; cough (productive or dry); shortness of breath; chest pain; fatigue; headache; confusion in severe cases
Root Cause:
Infections caused by Streptococcus pneumoniae, including pneumonia, bacteremia, and meningitis, often following viral respiratory infections or in individuals with compromised immunity.
How it's Diagnosed: videos
Chest X-ray for pneumonia, blood cultures for bacteremia, lumbar puncture for meningitis, and rapid antigen testing for S. pneumoniae.
Treatment:
Antibiotic therapy based on severity and resistance patterns, supportive care, and vaccination for prevention.
Medications:
Antibiotics - Penicillin, ceftriaxone , or vancomycin for severe cases; macrolides (e.g., azithromycin ) or fluoroquinolones for milder presentations. Vaccination - Pneumococcal conjugate vaccine (PCV13) and pneumococcal polysaccharide vaccine (PPSV23) for prevention.
Prevalence:
How common the health condition is within a specific population.
A leading cause of community-acquired pneumonia worldwide, particularly in children under 5 and adults over 65.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Age extremes, chronic diseases (e.g., diabetes, COPD), smoking, immunosuppression, and absence of vaccination.
Prognosis:
The expected outcome or course of the condition over time.
Good with timely treatment, though severe cases can lead to complications. Mortality is higher in meningitis or bacteremia.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Empyema, sepsis, meningitis, and hearing loss in meningitis survivors.
Psittacosis (Parrot Fever)
Specialty: Infectious Diseases
Category: Lower Respiratory Tract Infections
Symptoms:
fever; chills; headache; dry cough; muscle aches; shortness of breath; nausea; vomiting; fatigue
Root Cause:
Zoonotic infection caused by Chlamydia psittaci, typically transmitted through inhalation of dried droppings, secretions, or dust from infected birds.
How it's Diagnosed: videos
Diagnosis involves serologic testing for C. psittaci antibodies, PCR testing, and chest imaging to confirm pneumonia.
Treatment:
Antibiotic therapy is the primary treatment, often combined with supportive care for symptom relief.
Medications:
Antibiotics - Tetracyclines (e.g., doxycycline ) are the treatment of choice. Macrolides (e.g., azithromycin ) may be used as an alternative.
Prevalence:
How common the health condition is within a specific population.
Rare, primarily affecting individuals in close contact with birds, such as pet owners, veterinarians, and bird handlers.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Exposure to infected birds, handling bird droppings, or working in environments with birds.
Prognosis:
The expected outcome or course of the condition over time.
Good with appropriate treatment; most patients recover fully. Untreated cases can lead to severe complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Endocarditis, myocarditis, respiratory failure, and multi-organ dysfunction in severe cases.
Tularemia
Specialty: Infectious Diseases
Category: Lower Respiratory Tract Infections
Symptoms:
fever; chills; cough; difficulty breathing; chest pain; ulcerated skin lesions; swollen lymph nodes; fatigue
Root Cause:
Caused by Francisella tularensis, a bacterium transmitted through insect bites, contact with infected animals, inhalation, or contaminated water/food.
How it's Diagnosed: videos
Serologic testing for F. tularensis antibodies, PCR, or culture from blood or tissue samples. Chest imaging for pulmonary involvement.
Treatment:
Antibiotic therapy is the cornerstone of treatment, with supportive care for symptoms.
Medications:
Antibiotics - Streptomycin or gentamicin (aminoglycosides) are first-line treatments. Doxycycline or ciprofloxacin may be used as alternatives.
Prevalence:
How common the health condition is within a specific population.
Rare but can occur sporadically, especially in regions with high exposure to ticks or rabbits.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Handling infected animals, tick bites, laboratory exposure, and drinking untreated water.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with timely treatment; untreated cases can have a mortality rate of up to 30%.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Pneumonia, sepsis, chronic fatigue, and long-term organ damage.
Viral Pneumonia
Specialty: Infectious Diseases
Category: Lower Respiratory Tract Infections
Symptoms:
fever; cough; shortness of breath; fatigue; muscle aches; chills; headache
Root Cause:
Lung infection caused by viruses, such as influenza, respiratory syncytial virus (RSV), or coronaviruses, leading to inflammation of lung tissues and impaired oxygen exchange.
How it's Diagnosed: videos
PCR or antigen testing for the causative virus, chest X-ray or CT scan showing diffuse infiltrates, and blood tests for markers of inflammation.
Treatment:
Supportive care, including oxygen therapy, hydration, fever management, and antivirals in some cases.
Medications:
Antivirals - Oseltamivir for influenza , ribavirin for RSV in severe cases. Supportive medications - Antipyretics and bronchodilators for symptom relief.
Prevalence:
How common the health condition is within a specific population.
Common during viral outbreaks, such as seasonal influenza epidemics. RSV is particularly prevalent in young children and older adults.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Young age, advanced age, chronic diseases (e.g., asthma, COPD, heart disease), smoking, and immunosuppression.
Prognosis:
The expected outcome or course of the condition over time.
Most cases are mild and self-limiting. Severe cases, particularly in immunocompromised individuals, can lead to high mortality.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Respiratory failure, bacterial superinfection, ARDS, and chronic respiratory problems.
Leprosy
Specialty: Infectious Diseases
Category: Mycobacterial Infections
Symptoms:
skin lesions that are lighter than the surrounding skin or red in color; numbness or loss of sensation in the affected areas; muscle weakness; nerve damage; thickened or painful nerves; ulcers on the soles of the feet; loss of eyebrows or eyelashes
Root Cause:
Chronic infection caused by Mycobacterium leprae or Mycobacterium lepromatosis, which primarily affects the skin, peripheral nerves, mucosa of the upper respiratory tract, and eyes.
How it's Diagnosed: videos
Clinical evaluation of skin lesions, skin biopsy, slit-skin smears, and polymerase chain reaction (PCR) testing for bacterial DNA.
Treatment:
Multidrug therapy (MDT), which typically includes a combination of antibiotics over 6-12 months or longer. Supportive care for nerve damage and wound management.
Medications:
Antibiotics include dapsone (sulfonamide), rifampin (rifamycin ), and clofazimine (a riminophenazine dye). Prednisone or thalidomide may be prescribed for managing inflammation or leprosy reactions.
Prevalence:
How common the health condition is within a specific population.
Approximately 200,000 new cases annually worldwide, with the highest prevalence in India, Brazil, and Indonesia.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Close and prolonged contact with untreated individuals, genetic predisposition, living in endemic areas, poor sanitation, and weakened immune systems.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with early diagnosis and treatment; permanent nerve damage may occur in delayed or untreated cases.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Nerve damage, deformities, chronic ulcers, loss of limbs, blindness, and secondary infections.
Miliary Tuberculosis
Specialty: Infectious Diseases
Category: Mycobacterial Infections
Symptoms:
fever; night sweats; weight loss; general malaise; cough; difficulty breathing; enlarged liver or spleen; anemia
Root Cause:
Disseminated infection caused by Mycobacterium tuberculosis, leading to small nodular lesions in multiple organs due to hematogenous spread.
How it's Diagnosed: videos
Chest X-ray or CT scan showing millet-seed-like lesions, sputum culture, blood culture, liver biopsy, and tuberculin skin test (TST) or interferon-gamma release assay (IGRA).
Treatment:
Long-term combination therapy with first-line anti-tuberculosis medications, typically for 6-9 months. Supportive care and management of complications.
Medications:
First-line medications include isoniazid , rifampin , pyrazinamide , and ethambutol . Steroids may be added in cases of severe inflammation.
Prevalence:
How common the health condition is within a specific population.
Less common than pulmonary TB; often seen in immunocompromised individuals, particularly in areas with high TB burden.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
HIV infection, immunosuppressive therapy, chronic diseases, malnutrition, and living in or traveling to endemic regions.
Prognosis:
The expected outcome or course of the condition over time.
Variable; early treatment improves outcomes, but untreated cases can be fatal due to organ failure.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Respiratory failure, organ damage (e.g., liver, spleen), septic shock, and meningitis.
Mycobacterium Avium Complex (MAC) Infection
Specialty: Infectious Diseases
Category: Mycobacterial Infections
Symptoms:
chronic cough; weight loss; fatigue; low-grade fever; shortness of breath; night sweats; chest pain
Root Cause:
Caused by non-tuberculous mycobacteria (Mycobacterium avium and Mycobacterium intracellulare), leading to chronic pulmonary infection or disseminated disease, especially in immunocompromised individuals.
How it's Diagnosed: videos
Sputum culture, bronchoscopy, high-resolution CT scan, and histological examination of lung tissue.
Treatment:
Prolonged multidrug antibiotic therapy, often for 12 months or longer after culture conversion.
Medications:
Clarithromycin or azithromycin (macrolides), rifampin (rifamycin ), and ethambutol . Injectable amikacin may be used for severe cases.
Prevalence:
How common the health condition is within a specific population.
Increasing incidence worldwide, particularly in individuals with underlying lung disease or HIV/AIDS.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Chronic lung disease (e.g., COPD, bronchiectasis), immunosuppression, older age, and environmental exposure to contaminated water or soil.
Prognosis:
The expected outcome or course of the condition over time.
Favorable with early diagnosis and adherence to treatment; relapses may occur.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Progressive lung damage, respiratory failure, and systemic dissemination in immunocompromised individuals.
Mycobacterium Chelonae Infection
Specialty: Infectious Diseases
Category: Mycobacterial Infections
Symptoms:
red or tender nodules on the skin; non-healing ulcers; draining abscesses; systemic symptoms such as fever and fatigue (in disseminated cases)
Root Cause:
Infection caused by Mycobacterium chelonae, a rapidly growing non-tuberculous mycobacterium, often associated with skin and soft tissue infections.
How it's Diagnosed: videos
Culture and molecular identification of the organism from tissue, wound, or aspirate samples; histological examination; PCR testing.
Treatment:
Prolonged antibiotic therapy tailored to susceptibility testing, surgical debridement if necessary.
Medications:
Clarithromycin or azithromycin (macrolides), amikacin (aminoglycoside), cefoxitin (beta-lactam), and sometimes tigecycline or linezolid for resistant cases.
Prevalence:
How common the health condition is within a specific population.
Rare; typically associated with surgical procedures, contaminated medical devices, or environmental exposure.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Immunosuppression, recent surgery, trauma, chronic wounds, and exposure to contaminated water or medical equipment.
Prognosis:
The expected outcome or course of the condition over time.
Good with appropriate treatment, though prolonged therapy may be required. Severe or untreated cases can lead to systemic spread.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic non-healing wounds, abscess formation, systemic dissemination in immunocompromised individuals.
Mycobacterium Fortuitum Infection
Specialty: Infectious Diseases
Category: Mycobacterial Infections
Symptoms:
skin abscesses; ulcers; nodules; draining fistulas; systemic symptoms such as fever and malaise (in severe cases)
Root Cause:
Infection caused by Mycobacterium fortuitum, a rapidly growing non-tuberculous mycobacterium, affecting the skin, soft tissues, and occasionally the lungs.
How it's Diagnosed: videos
Culture of the organism from lesions, aspirates, or tissue biopsies; susceptibility testing; and imaging for systemic involvement.
Treatment:
Combination antibiotic therapy based on susceptibility results, with or without surgical debridement.
Medications:
Amikacin (aminoglycoside), clarithromycin or azithromycin (macrolides), ciprofloxacin or levofloxacin (fluoroquinolones), and doxycycline (tetracycline ).
Prevalence:
How common the health condition is within a specific population.
Rare; most cases occur after trauma, surgery, or exposure to contaminated water or medical equipment.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Recent invasive procedures, immunosuppression, and exposure to unsterile environments.
Prognosis:
The expected outcome or course of the condition over time.
Favorable with proper antibiotic treatment and surgical management when needed.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic infections, scarring, and potential systemic spread in immunocompromised individuals.
Mycobacterium Gordonae Infection
Specialty: Infectious Diseases
Category: Mycobacterial Infections
Symptoms:
asymptomatic in most cases; fever; weight loss; pulmonary symptoms (e.g., cough, chest pain); localized lymphadenitis
Root Cause:
Infection caused by Mycobacterium gordonae, a slow-growing non-tuberculous mycobacterium often considered non-pathogenic but capable of causing opportunistic infections in immunocompromised individuals.
How it's Diagnosed: videos
Culture from clinical specimens, molecular methods (e.g., PCR), and exclusion of other pathogens.
Treatment:
Antimicrobial therapy for symptomatic cases, guided by susceptibility testing; typically involves a multidrug regimen.
Medications:
Clarithromycin or azithromycin (macrolides), rifampin (rifamycin ), and ethambutol . Other agents like amikacin or ciprofloxacin may be used in resistant cases.
Prevalence:
How common the health condition is within a specific population.
Rarely pathogenic; commonly found in the environment, especially in water sources.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Immunosuppression, chronic lung disease, and exposure to contaminated water.
Prognosis:
The expected outcome or course of the condition over time.
Generally good with appropriate treatment; mild or asymptomatic cases often do not require intervention.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Invasive infections in severely immunocompromised individuals, including bloodstream infections and organ involvement.
Mycobacterium Haemophilum Infection
Specialty: Infectious Diseases
Category: Mycobacterial Infections
Symptoms:
skin lesions; arthritis; osteomyelitis; fever; swollen lymph nodes
Root Cause:
Caused by Mycobacterium haemophilum, which is an opportunistic pathogen, primarily affecting immunocompromised individuals.
How it's Diagnosed: videos
Culture on iron-enriched media or molecular diagnostic methods such as PCR; biopsy of infected tissue.
Treatment:
Combination antibiotic therapy tailored based on susceptibility testing.
Medications:
Antibiotics such as clarithromycin (macrolide), rifampin (rifamycin ), and ethambutol (antimycobacterial agent) are commonly prescribed.
Prevalence:
How common the health condition is within a specific population.
Rare; most cases occur in immunocompromised patients, particularly those undergoing chemotherapy or organ transplantation.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Immunosuppression, cancer, HIV/AIDS, organ transplantation, or use of immunosuppressive therapy.
Prognosis:
The expected outcome or course of the condition over time.
Variable; good with appropriate treatment but may be severe or fatal in severely immunocompromised individuals.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Disseminated infection, chronic skin or bone involvement, and systemic disease.
Mycobacterium Kansasii Infection
Specialty: Infectious Diseases
Category: Mycobacterial Infections
Symptoms:
chronic cough; fever; weight loss; night sweats; fatigue; lung infiltrates
Root Cause:
Caused by Mycobacterium kansasii, primarily affecting the lungs and mimicking tuberculosis.
How it's Diagnosed: videos
Sputum culture, molecular testing (PCR), and chest imaging (e.g., X-ray or CT scan).
Treatment:
Combination therapy, including multiple antibiotics over 12-18 months.
Medications:
Rifampin (rifamycin ), ethambutol (antimycobacterial agent), and isoniazid (antitubercular agent) are typically prescribed.
Prevalence:
How common the health condition is within a specific population.
Rare; primarily affects individuals with underlying lung diseases or immunocompromised states.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Chronic obstructive pulmonary disease (COPD), HIV/AIDS, prior tuberculosis, and immunosuppressive therapies.
Prognosis:
The expected outcome or course of the condition over time.
Generally good with timely diagnosis and appropriate treatment.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic pulmonary disease, progression to disseminated infection in immunocompromised patients.
Mycobacterium Marinum Infection
Specialty: Infectious Diseases
Category: Mycobacterial Infections
Symptoms:
localized skin nodules; ulcers; swelling near the site of trauma; redness; pain
Root Cause:
Caused by Mycobacterium marinum, often acquired through exposure to contaminated water or aquatic animals.
How it's Diagnosed: videos
Skin biopsy, culture on special media, and PCR for rapid identification.
Treatment:
Prolonged antibiotic therapy, typically lasting several months.
Medications:
Clarithromycin (macrolide), doxycycline (tetracycline ), and rifampin (rifamycin ) are commonly used.
Prevalence:
How common the health condition is within a specific population.
Uncommon; occurs in individuals exposed to contaminated water or fish.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Aquatic hobbies or occupations, trauma to the skin, and immunosuppression.
Prognosis:
The expected outcome or course of the condition over time.
Good with appropriate antibiotic therapy.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Persistent infection, tenosynovitis, or deeper tissue involvement in untreated cases.
Mycobacterium Xenopi Infection
Specialty: Infectious Diseases
Category: Mycobacterial Infections
Symptoms:
chronic cough; fever; night sweats; weight loss; dyspnea
Root Cause:
An opportunistic infection caused by Mycobacterium xenopi, often affecting the lungs.
How it's Diagnosed: videos
Sputum culture, chest imaging, and molecular testing such as PCR.
Treatment:
Long-term antibiotic therapy based on drug susceptibility.
Medications:
Rifampin (rifamycin ), ethambutol (antimycobacterial agent), and clarithromycin (macrolide) are frequently prescribed.
Prevalence:
How common the health condition is within a specific population.
Rare; more common in individuals with structural lung diseases or weakened immune systems.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Chronic lung diseases, HIV/AIDS, and immunosuppressive therapy.
Prognosis:
The expected outcome or course of the condition over time.
Favorable with treatment; may lead to chronic pulmonary disease if untreated.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Cavitary lung disease, chronic infection, and dissemination in immunocompromised patients.
Tuberculosis (TB)
Specialty: Infectious Diseases
Category: Mycobacterial Infections
Symptoms:
persistent cough (lasting > 3 weeks); fever; night sweats; weight loss; hemoptysis; fatigue
Root Cause:
Caused by Mycobacterium tuberculosis, leading to pulmonary or extrapulmonary disease.
How it's Diagnosed: videos
Sputum microscopy and culture, chest X-ray, tuberculin skin test (TST), or interferon-gamma release assay (IGRA).
Treatment:
Standard 6-month course of combination antibiotic therapy.
Medications:
Rifampin (rifamycin ), isoniazid (antitubercular agent), pyrazinamide , and ethambutol (antimycobacterial agent).
Prevalence:
How common the health condition is within a specific population.
Affects millions globally; highest prevalence in low-income countries.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
HIV/AIDS, malnutrition, overcrowding, and weakened immunity.
Prognosis:
The expected outcome or course of the condition over time.
Good with timely diagnosis and adherence to treatment; untreated TB can be fatal.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Drug-resistant TB, miliary TB, and organ damage.
Tuberculosis Organism-Specific Therapy
Specialty: Infectious Diseases
Category: Mycobacterial Infections
Symptoms:
persistent cough; fever; weight loss; night sweats; hemoptysis
Root Cause:
Treatment of TB tailored to specific drug susceptibility profiles of Mycobacterium tuberculosis.
How it's Diagnosed: videos
Drug susceptibility testing, molecular diagnostics (e.g., GeneXpert), and culture.
Treatment:
Customized antibiotic regimens based on drug-resistance patterns.
Medications:
Fluoroquinolones (e.g., levofloxacin ), linezolid (oxazolidinone), and bedaquiline (diarylquinoline) for resistant cases.
Prevalence:
How common the health condition is within a specific population.
Common in drug-resistant TB cases.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Poor adherence to standard TB therapy, prior TB treatment, and immunosuppression.
Prognosis:
The expected outcome or course of the condition over time.
Variable; drug-resistant TB is harder to treat and associated with higher mortality.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Treatment failure, extensive drug resistance, and systemic spread of TB.
Acanthamoeba Infection
Specialty: Infectious Diseases
Category: Parasitic Infections
Symptoms:
red eyes; severe eye pain; blurred vision; sensitivity to light; excessive tearing; corneal ulceration
Root Cause:
Infection caused by the Acanthamoeba protozoan, which invades the cornea, often due to contact lens use, contaminated water exposure, or corneal trauma.
How it's Diagnosed: videos
Clinical evaluation, corneal scraping for microscopic examination, culture for Acanthamoeba, polymerase chain reaction (PCR) testing, and confocal microscopy.
Treatment:
Intensive antimicrobial therapy, primarily with topical agents. Advanced cases may require corneal transplantation.
Medications:
Polyhexamethylene biguanide (PHMB) and chlorhexidine are antiseptics often prescribed for Acanthamoeba keratitis. Propamidine isethionate and neomycin (antibiotics) may be used in combination. Oral antifungal agents such as itraconazole may be used in severe cases.
Prevalence:
How common the health condition is within a specific population.
Rare but increasingly reported, particularly among contact lens users.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Poor contact lens hygiene, exposure to contaminated water (e.g., swimming pools, hot tubs), corneal trauma, and immunosuppression.
Prognosis:
The expected outcome or course of the condition over time.
Good if diagnosed early; delayed treatment can result in severe vision impairment or blindness.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Corneal scarring, secondary bacterial or fungal infections, and blindness.
African Trypanosomiasis (Sleeping Sickness)
Specialty: Infectious Diseases
Category: Parasitic Infections
Symptoms:
fever; headache; joint pain; itching; swelling of lymph nodes; confusion; personality changes; severe sleep disturbances; neurological impairments
Root Cause:
Caused by the protozoan Trypanosoma brucei species transmitted via tsetse fly bites, leading to systemic and central nervous system infection.
How it's Diagnosed: videos
Blood smear microscopy, serological tests, lumbar puncture to detect trypanosomes in cerebrospinal fluid (CSF).
Treatment:
Antiparasitic therapy, depending on the disease stage.
Medications:
Pentamidine (for early-stage T. brucei gambiense), suramin (for early-stage T. brucei rhodesiense), melarsoprol (for late-stage CNS involvement), eflornithine , or fexinidazole (recently approved oral treatment).
Prevalence:
How common the health condition is within a specific population.
Endemic to sub-Saharan Africa, with periodic outbreaks. Cases have decreased due to control programs.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Living in or traveling to endemic areas, exposure to tsetse fly habitats, and lack of protective measures.
Prognosis:
The expected outcome or course of the condition over time.
Early treatment leads to recovery; untreated cases are fatal.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Neurological damage, seizures, coma, and death in advanced stages.
Alveolar Echinococcosis (AE)
Specialty: Infectious Diseases
Category: Parasitic Infections
Symptoms:
abdominal pain; weight loss; jaundice; liver enlargement; nausea; weakness
Root Cause:
Caused by the larval stage of Echinococcus multilocularis, which forms invasive cysts, primarily in the liver.
How it's Diagnosed: videos
Imaging studies (ultrasound, CT, MRI), serological testing for Echinococcus antibodies, and biopsy for definitive diagnosis.
Treatment:
Surgical removal of the lesion when possible, long-term antiparasitic therapy.
Medications:
Albendazole (anthelmintic) is the primary medication; mebendazole is an alternative.
Prevalence:
How common the health condition is within a specific population.
Rare, primarily found in the northern hemisphere, including parts of Europe, Asia, and North America.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Contact with infected animals (e.g., dogs, foxes), consuming contaminated food or water, and living in endemic regions.
Prognosis:
The expected outcome or course of the condition over time.
Good with early detection and treatment; untreated cases have a poor prognosis due to invasive growth.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Liver failure, metastasis to other organs, secondary infections.
Amebiasis
Specialty: Infectious Diseases
Category: Parasitic Infections
Symptoms:
diarrhea; abdominal pain; cramping; bloody stools; fever; weight loss
Root Cause:
Infection with Entamoeba histolytica through ingestion of contaminated food or water, causing intestinal and, in some cases, extraintestinal infections such as liver abscesses.
How it's Diagnosed: videos
Stool examination for trophozoites or cysts, antigen detection tests, serological assays, imaging (ultrasound or CT) for liver abscesses.
Treatment:
Antiparasitic medications, drainage of liver abscesses if necessary.
Medications:
Metronidazole or tinidazole (antiprotozoal drugs) are used for tissue-invasive disease, followed by luminal agents like paromomycin or iodoquinol to eliminate cysts in the intestine.
Prevalence:
How common the health condition is within a specific population.
Common in tropical and subtropical regions, particularly in areas with poor sanitation.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Poor hygiene, contaminated water supply, close contact with infected individuals.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with prompt treatment; severe cases can lead to complications if untreated.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Liver abscesses, perforation of the colon, peritonitis, and dissemination to other organs.
Ascariasis
Specialty: Infectious Diseases
Category: Parasitic Infections
Symptoms:
abdominal pain; nausea; vomiting; malnutrition; intestinal blockage; cough (during larval migration)
Root Cause:
Infection with Ascaris lumbricoides, a roundworm transmitted through ingestion of eggs from contaminated soil or food.
How it's Diagnosed: videos
Stool analysis for eggs, imaging studies for intestinal obstruction, and sometimes ultrasound or CT for heavy infections.
Treatment:
Anthelmintic medications, sometimes surgery for complications.
Medications:
Albendazole or mebendazole are commonly prescribed; pyrantel pamoate is an alternative.
Prevalence:
How common the health condition is within a specific population.
Highly prevalent in tropical and subtropical regions, especially in areas with poor sanitation.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Contaminated soil or water, poor hygiene, and living in endemic areas.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with treatment; severe cases with complications may require additional interventions.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Intestinal obstruction, malnutrition, growth retardation in children, and migration of worms to other organs.
Babesiosis
Specialty: Infectious Diseases
Category: Parasitic Infections
Symptoms:
fever; chills; sweats; fatigue; headache; anemia; dark urine
Root Cause:
Infection with Babesia protozoa transmitted by Ixodes tick bites, leading to red blood cell destruction.
How it's Diagnosed: videos
Blood smear for Babesia parasites, PCR testing, or serological assays.
Treatment:
Combination antimicrobial therapy.
Medications:
Atovaquone (antiprotozoal) combined with azithromycin (antibiotic), or clindamycin with quinine in severe cases.
Prevalence:
How common the health condition is within a specific population.
Found in areas where Ixodes ticks are prevalent, such as the northeastern and upper midwestern United States.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Tick exposure, asplenia, advanced age, and immunosuppression.
Prognosis:
The expected outcome or course of the condition over time.
Good for healthy individuals; severe disease in immunocompromised or splenectomized patients can be fatal without treatment.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Hemolytic anemia, organ failure, and death in severe cases.
Balantidiasis
Specialty: Infectious Diseases
Category: Parasitic Infections
Symptoms:
diarrhea; abdominal pain; nausea; vomiting; fever; weight loss
Root Cause:
Infection with Balantidium coli, a ciliate protozoan, typically acquired from contaminated food or water.
How it's Diagnosed: videos
Stool examination for trophozoites or cysts; rarely, colonoscopy and biopsy.
Treatment:
Antiprotozoal therapy.
Medications:
Tetracycline is the first-line treatment; metronidazole or iodoquinol are alternatives.
Prevalence:
How common the health condition is within a specific population.
Rare, typically found in areas with poor sanitation and exposure to swine.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Close contact with pigs, contaminated water, and poor hygiene.
Prognosis:
The expected outcome or course of the condition over time.
Good with treatment; untreated severe cases may lead to complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Perforation of the colon, peritonitis.
Chagas Disease
Specialty: Infectious Diseases
Category: Parasitic Infections
Symptoms:
fever; swelling at infection site; fatigue; rash; digestive issues; cardiomyopathy
Root Cause:
Caused by Trypanosoma cruzi, transmitted via triatomine bug feces, blood transfusion, or congenitally.
How it's Diagnosed: videos
Blood smear in acute stage, serological tests in chronic stage, and imaging for organ involvement.
Treatment:
Antiparasitic treatment for acute and early chronic phases; supportive care for complications.
Medications:
Benznidazole and nifurtimox are antiparasitic agents for early-stage treatment.
Prevalence:
How common the health condition is within a specific population.
Endemic in Latin America but increasingly reported in non-endemic regions due to migration.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Living in endemic areas, poor housing conditions, and exposure to triatomine bugs.
Prognosis:
The expected outcome or course of the condition over time.
Early treatment improves outcomes; chronic cases may have severe complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Heart failure, arrhythmias, megaesophagus, and megacolon.
Cryptosporidiosis
Specialty: Infectious Diseases
Category: Parasitic Infections
Symptoms:
watery diarrhea; abdominal pain; nausea; vomiting; fever; weight loss; dehydration
Root Cause:
Infection with Cryptosporidium species, primarily transmitted through ingestion of contaminated water or food.
How it's Diagnosed: videos
Stool analysis using acid-fast staining, direct fluorescent antibody tests, or PCR for Cryptosporidium DNA.
Treatment:
Supportive care to prevent dehydration; specific antiparasitic therapy for immunocompromised individuals.
Medications:
Nitazoxanide (antiprotozoal) is the primary treatment. Antidiarrheal agents may be used for symptom control.
Prevalence:
How common the health condition is within a specific population.
Common worldwide, especially in children and immunocompromised individuals in low-resource settings.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Contaminated water sources, poor sanitation, immunosuppression (e.g., HIV/AIDS).
Prognosis:
The expected outcome or course of the condition over time.
Good for immunocompetent individuals; chronic or severe disease in immunosuppressed patients.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Severe dehydration, malnutrition, and chronic diarrhea in immunocompromised individuals.
Cutaneous Larva Migrans (CLM)
Specialty: Infectious Diseases
Category: Parasitic Infections
Symptoms:
itchy, winding rash; localized swelling; redness; burning sensation at the site of larval migration
Root Cause:
Caused by the larvae of hookworms (e.g., Ancylostoma braziliense) penetrating human skin, typically from contact with contaminated soil or sand.
How it's Diagnosed: videos
Clinical diagnosis based on characteristic appearance of the rash and travel or exposure history.
Treatment:
Antiparasitic medications and symptomatic relief for itching.
Medications:
Albendazole or ivermectin (anthelmintics) are the primary treatments. Topical thiabendazole may be used for localized infections.
Prevalence:
How common the health condition is within a specific population.
Found in tropical and subtropical regions, particularly among travelers or residents exposed to contaminated beaches or soil.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Walking barefoot on contaminated soil, contact with infected animals, or exposure in endemic areas.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with treatment; self-limiting in many cases but may last weeks to months without intervention.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Secondary bacterial infections due to scratching and prolonged irritation.
Cystoisosporiasis
Specialty: Infectious Diseases
Category: Parasitic Infections
Symptoms:
watery diarrhea; abdominal pain; cramping; nausea; vomiting; weight loss; fever
Root Cause:
Infection with Cystoisospora belli (formerly known as Isospora belli), a parasitic protozoan that invades the epithelial cells of the small intestine.
How it's Diagnosed: videos
Microscopic examination of stool samples to detect oocysts; acid-fast staining or molecular tests (e.g., PCR) may be used.
Treatment:
Primarily with antiparasitic medication and supportive care (rehydration and nutritional support).
Medications:
Trimethoprim-sulfamethoxazole (antibiotic combination, also known as Bactrim ) is the first-line treatment. For sulfa-allergic patients, pyrimethamine with leucovorin (folic acid) may be used.
Prevalence:
How common the health condition is within a specific population.
Rare in developed countries; more common in tropical and subtropical regions and in immunocompromised individuals (e.g., HIV/AIDS).
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Immunosuppression, travel to or residence in endemic areas, poor sanitation, consumption of contaminated food or water.
Prognosis:
The expected outcome or course of the condition over time.
Good with prompt treatment; chronic or recurrent infections may occur in immunocompromised patients.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic diarrhea, malabsorption, dehydration, and significant weight loss, especially in immunocompromised individuals.
Diphyllobothriasis
Specialty: Infectious Diseases
Category: Parasitic Infections
Symptoms:
abdominal discomfort; nausea; diarrhea or constipation; weakness; weight loss; vitamin b12 deficiency symptoms like anemia or numbness
Root Cause:
Infection with the fish tapeworm (Diphyllobothrium latum), acquired through ingestion of raw or undercooked freshwater fish containing larvae.
How it's Diagnosed: videos
Identification of eggs or segments (proglottids) in stool samples; PCR may be used for species confirmation.
Treatment:
Anthelmintic medications and nutritional supplementation for vitamin B12 deficiency if present.
Medications:
Praziquantel (anthelmintic) is the drug of choice. Niclosamide can also be used as an alternative.
Prevalence:
How common the health condition is within a specific population.
Common in regions where raw or undercooked fish is consumed, such as Scandinavia, Russia, and parts of Japan, Peru, and North America.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Eating raw or undercooked freshwater fish, poor food preparation practices, or living in endemic areas.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with treatment; complications are rare.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Severe vitamin B12 deficiency leading to megaloblastic anemia, neurological symptoms, and intestinal obstruction in rare cases.
Dipylidiasis
Specialty: Infectious Diseases
Category: Parasitic Infections
Symptoms:
mild gastrointestinal discomfort; diarrhea; abdominal pain; anal pruritus; irritability in children
Root Cause:
Infection with Dipylidium caninum, a tapeworm transmitted through ingestion of infected fleas or flea larvae.
How it's Diagnosed: videos
Detection of proglottids in stool or around the perianal area; microscopic identification of egg packets in stool samples.
Treatment:
Anthelmintic medications combined with flea control measures to prevent reinfection.
Medications:
Praziquantel (anthelmintic) is the treatment of choice.
Prevalence:
How common the health condition is within a specific population.
Sporadic cases globally; commonly associated with children and pet owners due to close contact with dogs and cats.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Exposure to infected pets or fleas, lack of flea control, and poor hygiene practices.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with treatment; minimal risk of complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Rare; potential reinfection if flea control is inadequate.
Dirofilariasis
Specialty: Infectious Diseases
Category: Parasitic Infections
Symptoms:
subcutaneous nodules; pain or swelling at the site; pulmonary symptoms like cough, chest pain, or fever in cases of lung involvement
Root Cause:
Infection with Dirofilaria species, primarily Dirofilaria immitis or Dirofilaria repens, transmitted through mosquito bites.
How it's Diagnosed: videos
Histological examination of excised nodules or imaging studies (e.g., chest X-ray or CT scan) for pulmonary involvement.
Treatment:
Surgical removal of nodules or lesions; antiparasitic drugs are not typically needed.
Medications:
No standard drug treatment; management is primarily surgical. Preventive measures include mosquito control.
Prevalence:
How common the health condition is within a specific population.
Found in tropical and temperate regions, particularly in areas with high mosquito populations.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Living in or traveling to endemic areas, exposure to mosquitoes.
Prognosis:
The expected outcome or course of the condition over time.
Good with appropriate management; complications are rare.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Pulmonary involvement can mimic malignancy, leading to invasive diagnostic procedures.
Echinococcosis (Hydatid Cyst)
Specialty: Infectious Diseases
Category: Parasitic Infections
Symptoms:
abdominal pain; nausea; vomiting; cyst-related pressure effects; allergic reactions if the cyst ruptures
Root Cause:
Infection with Echinococcus granulosus or Echinococcus multilocularis, causing cystic or alveolar echinococcosis, respectively.
How it's Diagnosed: videos
Imaging studies (ultrasound, CT, or MRI), serological tests (ELISA, Western blot), and histopathological examination.
Treatment:
Surgical removal of cysts, percutaneous aspiration (PAIR technique), or antiparasitic drug therapy for inoperable cases.
Medications:
Albendazole and mebendazole (anthelmintics) are used to reduce cyst size or as adjuncts to surgery.
Prevalence:
How common the health condition is within a specific population.
Endemic in sheep-raising regions such as the Middle East, Central Asia, South America, and parts of Africa.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Contact with infected dogs, livestock farming, poor hygiene practices.
Prognosis:
The expected outcome or course of the condition over time.
Variable; excellent with early intervention, but alveolar echinococcosis can be life-threatening if untreated.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Cyst rupture leading to anaphylaxis, secondary bacterial infections, or dissemination of the infection.
Filariasis
Specialty: Infectious Diseases
Category: Parasitic Infections
Symptoms:
lymphedema; elephantiasis; hydrocele; fever; lymphangitis
Root Cause:
Infection with filarial nematodes, primarily Wuchereria bancrofti, Brugia malayi, or Brugia timori, transmitted via mosquito bites.
How it's Diagnosed: videos
Blood smear microscopy to detect microfilariae, antigen detection tests, and ultrasound for adult worms.
Treatment:
Antiparasitic drugs, supportive care for lymphedema, and surgical management of hydrocele or elephantiasis.
Medications:
Diethylcarbamazine (DEC), ivermectin , and albendazole are used alone or in combination.
Prevalence:
How common the health condition is within a specific population.
Endemic in tropical and subtropical regions, affecting millions in Africa, Asia, and the Pacific.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Exposure to mosquito bites in endemic areas, poor mosquito control measures.
Prognosis:
The expected outcome or course of the condition over time.
Treatable in early stages; chronic conditions may require long-term management.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Severe lymphedema, secondary bacterial infections, and social stigma due to disfigurement.
Hookworm Disease
Specialty: Infectious Diseases
Category: Parasitic Infections
Symptoms:
iron deficiency anemia; fatigue; abdominal pain; diarrhea; nausea; itching and rash at the site of skin penetration (ground itch)
Root Cause:
Infection with hookworms such as Ancylostoma duodenale or Necator americanus, which attach to the intestinal lining and feed on blood.
How it's Diagnosed: videos
Stool examination for eggs or larvae; molecular methods may confirm the species.
Treatment:
Anthelmintic medications and iron supplementation for anemia.
Medications:
Albendazole or mebendazole (anthelmintics) are the drugs of choice. Pyrantel pamoate can be used as an alternative.
Prevalence:
How common the health condition is within a specific population.
Common in tropical and subtropical regions with poor sanitation.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Walking barefoot on contaminated soil, poor sanitation, and inadequate access to clean water.
Prognosis:
The expected outcome or course of the condition over time.
Good with treatment; untreated infections may lead to severe anemia and developmental delays in children.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic anemia, malnutrition, and growth retardation in children.
Intestinal Flukes
Specialty: Infectious Diseases
Category: Parasitic Infections
Symptoms:
abdominal pain; diarrhea; nausea; malabsorption; weakness
Root Cause:
Infection with trematodes such as Fasciolopsis buski, acquired through ingestion of raw or undercooked aquatic plants contaminated with metacercariae.
How it's Diagnosed: videos
Stool examination for eggs; imaging or serological tests may assist in diagnosis.
Treatment:
Anthelmintic medications and supportive care for symptoms.
Medications:
Praziquantel (anthelmintic) is the treatment of choice. Nitazoxanide may be considered in some cases.
Prevalence:
How common the health condition is within a specific population.
Common in parts of Southeast Asia and India where aquatic plants are consumed.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Consumption of contaminated water plants (e.g., water chestnuts), poor sanitation, and exposure to infected water sources.
Prognosis:
The expected outcome or course of the condition over time.
Good with appropriate treatment; complications are rare.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic malabsorption and malnutrition if untreated.
Leishmaniasis
Specialty: Infectious Diseases
Category: Parasitic Infections
Symptoms:
fever; weight loss; swollen lymph nodes; skin sores; enlarged spleen and liver; anemia; fatigue
Root Cause:
Infection caused by Leishmania parasites transmitted through the bite of infected sandflies.
How it's Diagnosed: videos
Microscopic examination of tissue samples, polymerase chain reaction (PCR), serological tests, or parasite culture.
Treatment:
Antiparasitic medications, supportive care for organ involvement, and wound management for skin lesions.
Medications:
Pentavalent antimonials (e.g., sodium stibogluconate, meglumine antimoniate), liposomal amphotericin B (especially for visceral leishmaniasis), miltefosine (an oral antiprotozoal), paromomycin (an aminoglycoside antibiotic).
Prevalence:
How common the health condition is within a specific population.
Endemic in tropical and subtropical regions, affecting over 12 million people globally, with 1–2 million new cases annually.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Poor housing, malnutrition, deforestation, exposure to sandfly habitats, immunosuppression (e.g., HIV co-infection).
Prognosis:
The expected outcome or course of the condition over time.
Treatable with timely medical intervention; visceral leishmaniasis can be fatal without treatment.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Post-kala-azar dermal leishmaniasis, secondary infections, organ damage, and chronic skin ulcers.
Loiasis (African Eye Worm)
Specialty: Infectious Diseases
Category: Parasitic Infections
Symptoms:
skin swelling (calabar swelling); migrating worms visible under the skin or in the eye; itching; joint pain; fatigue
Root Cause:
Caused by the Loa loa filarial worm transmitted through the bite of infected deerflies.
How it's Diagnosed: videos
Microscopic examination of blood samples (daytime blood smear), polymerase chain reaction (PCR), and visualization of adult worms.
Treatment:
Antiparasitic medications to kill adult and larval worms, along with symptomatic treatment for itching and swelling.
Medications:
Diethylcarbamazine (DEC, an anti-helminthic), ivermectin (for larval microfilariae), albendazole (a broad-spectrum antiparasitic).
Prevalence:
How common the health condition is within a specific population.
Endemic in rainforests of Central and West Africa; estimated 10–20 million people infected.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Living or traveling in endemic regions, exposure to infected deerflies.
Prognosis:
The expected outcome or course of the condition over time.
Treatable with antiparasitics, but severe worm burden can cause complications during treatment.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Kidney damage, heart problems, encephalopathy (rare, associated with high worm loads during treatment).
Malaria
Specialty: Infectious Diseases
Category: Parasitic Infections
Symptoms:
fever; chills; headache; nausea; vomiting; muscle pain; anemia; sweating; enlarged spleen
Root Cause:
Infection by Plasmodium parasites (e.g., P. falciparum, P. vivax) transmitted by infected Anopheles mosquitoes.
How it's Diagnosed: videos
Microscopy (blood smears), rapid diagnostic tests (RDTs), and polymerase chain reaction (PCR).
Treatment:
Antimalarial medications, supportive care for complications (e.g., blood transfusions for severe anemia).
Medications:
Artemisinin-based combination therapies (ACTs, e.g., artemether-lumefantrine), chloroquine (for chloroquine-sensitive strains), primaquine (for liver-stage hypnozoites), atovaquone-proguanil, and quinine .
Prevalence:
How common the health condition is within a specific population.
Affects 240 million people annually, with the highest burden in sub-Saharan Africa.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Living in endemic areas, lack of insecticide-treated bed nets, poverty, and pregnancy.
Prognosis:
The expected outcome or course of the condition over time.
Treatable, but severe malaria can cause death if untreated, especially in children and pregnant women.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Cerebral malaria, severe anemia, organ failure, and hypoglycemia.
Malaria Organism-Specific Therapy
Specialty: Infectious Diseases
Category: Parasitic Infections
Symptoms:
fever; chills; sweating; headache; nausea; vomiting; muscle aches; anemia
Root Cause:
Infection caused by specific Plasmodium species (P. falciparum, P. vivax, P. ovale, P. malariae, or P. knowlesi). Treatment tailored to the infecting species, drug resistance, and location.
How it's Diagnosed: videos
Microscopy, species-specific rapid diagnostic tests (RDTs), and PCR.
Treatment:
Therapy varies by species; includes addressing blood-stage parasites and dormant liver stages (P. vivax and P. ovale).
Medications:
P. falciparum - Artemisinin-based combination therapies (ACTs, e.g., artemether-lumefantrine). P. vivax - Chloroquine or ACTs for blood-stage; primaquine or tafenoquine for liver-stage hypnozoites. P. malariae and P. ovale - Similar to P. vivax protocols. P. knowlesi - Treated with ACTs or chloroquine .
Prevalence:
How common the health condition is within a specific population.
Regional variations; P. falciparum most common in Africa, P. vivax predominant outside sub-Saharan Africa.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Traveling or living in endemic areas, lack of preventive measures (e.g., bed nets, prophylaxis).
Prognosis:
The expected outcome or course of the condition over time.
Effective treatment reduces mortality; early diagnosis critical. Untreated cases can lead to severe complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Severe malaria, organ failure, cerebral malaria, hypoglycemia.
Microsporidiosis
Specialty: Infectious Diseases
Category: Parasitic Infections
Symptoms:
chronic diarrhea; abdominal pain; weight loss; nausea; vomiting; fever; ocular inflammation (in cases of eye involvement)
Root Cause:
Caused by microsporidia, intracellular parasites primarily affecting immunocompromised individuals.
How it's Diagnosed: videos
Microscopy (modified trichrome stain), PCR, and electron microscopy.
Treatment:
Antiparasitic medications, rehydration therapy, and managing underlying immunosuppression.
Medications:
Albendazole (a broad-spectrum antiparasitic) for systemic infections; fumagillin or topical agents for ocular infections.
Prevalence:
How common the health condition is within a specific population.
Found worldwide, particularly in HIV/AIDS patients and organ transplant recipients.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Immunosuppression (e.g., HIV/AIDS, chemotherapy), exposure to contaminated water or food.
Prognosis:
The expected outcome or course of the condition over time.
Treatable, but complications are more severe in immunocompromised individuals.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic malabsorption, systemic spread, and severe organ-specific infections.
Nematode Infections
Specialty: Infectious Diseases
Category: Parasitic Infections
Symptoms:
abdominal pain; diarrhea; malnutrition; anemia; skin rashes; itching; respiratory symptoms in some cases
Root Cause:
Caused by roundworms such as Ascaris lumbricoides, Ancylostoma duodenale (hookworms), and Strongyloides stercoralis.
How it's Diagnosed: videos
Stool examination for eggs or larvae, blood tests for eosinophilia, and PCR for species identification.
Treatment:
Antiparasitic medications and supportive care for malnutrition or anemia.
Medications:
Albendazole or mebendazole (broad-spectrum anti-helminthics), ivermectin (for strongyloidiasis), pyrantel pamoate (for specific nematodes).
Prevalence:
How common the health condition is within a specific population.
Affects over 1.5 billion people worldwide, especially in tropical and subtropical regions.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Poor sanitation, contaminated water, lack of hygiene, barefoot walking in endemic areas.
Prognosis:
The expected outcome or course of the condition over time.
Treatable, but chronic infections can cause growth retardation and severe complications in children.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Intestinal obstruction, nutritional deficiencies, and systemic infection (e.g., disseminated strongyloidiasis).
Onchocerciasis (River Blindness)
Specialty: Infectious Diseases
Category: Parasitic Infections
Symptoms:
itching; skin rashes; nodules under the skin; vision changes; progressive blindness
Root Cause:
Caused by Onchocerca volvulus, a filarial worm transmitted by blackflies.
How it's Diagnosed: videos
Skin snip biopsy, PCR, or detection of nodules and microfilariae.
Treatment:
Antiparasitic medications and community-wide treatment programs.
Medications:
Ivermectin (kills microfilariae), doxycycline (kills Wolbachia bacteria within adult worms).
Prevalence:
How common the health condition is within a specific population.
Over 20 million affected, primarily in sub-Saharan Africa, with smaller foci in Latin America and Yemen.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Living in or near fast-flowing rivers in endemic regions.
Prognosis:
The expected outcome or course of the condition over time.
Treatable with ivermectin; blindness can be prevented with early treatment.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Irreversible blindness, severe itching leading to skin damage, and nodular skin disease.
Pinworm (Enterobiasis)
Specialty: Infectious Diseases
Category: Parasitic Infections
Symptoms:
perianal itching; restlessness; irritability; abdominal pain; loss of appetite
Root Cause:
Caused by Enterobius vermicularis, a small intestinal nematode transmitted through ingestion of eggs.
How it's Diagnosed: videos
Visualization of worms or eggs on the perianal area using the "tape test."
Treatment:
Antiparasitic medications and hygiene measures to prevent reinfection.
Medications:
Mebendazole or albendazole (broad-spectrum anti-helminthics), pyrantel pamoate .
Prevalence:
How common the health condition is within a specific population.
Common worldwide, especially among children in crowded settings.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Poor hygiene, close contact with infected individuals.
Prognosis:
The expected outcome or course of the condition over time.
Easily treatable with medications and proper hygiene.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Rarely, chronic infections can cause appendicitis or other gastrointestinal issues.
Sarcosporidiosis
Specialty: Infectious Diseases
Category: Parasitic Infections
Symptoms:
muscle pain; weakness; fever; diarrhea; nausea; subcutaneous nodules
Root Cause:
Caused by Sarcocystis parasites, typically transmitted through the ingestion of undercooked meat containing parasitic cysts or contaminated water.
How it's Diagnosed: videos
Stool examination for oocysts, muscle biopsy for cyst identification, and serological tests for antibodies.
Treatment:
Management includes supportive care for symptomatic relief and antiparasitic medications for severe cases.
Medications:
Albendazole , an antiparasitic, is often prescribed. Corticosteroids may be used to manage inflammation in severe cases.
Prevalence:
How common the health condition is within a specific population.
Rare in developed countries; prevalence higher in regions with poor sanitation and raw meat consumption.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Consumption of undercooked meat, poor sanitation, exposure to contaminated water.
Prognosis:
The expected outcome or course of the condition over time.
Generally good with treatment, though chronic muscle symptoms may persist in some cases.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic muscle pain, weakness, and rare cases of systemic involvement.
Schistosomiasis (Bilharzia)
Specialty: Infectious Diseases
Category: Parasitic Infections
Symptoms:
rash or itchy skin; fever; chills; cough; abdominal pain; diarrhea; blood in urine or stool; fatigue
Root Cause:
Caused by infection with Schistosoma parasites, transmitted through contact with freshwater containing the larval form of the parasite.
How it's Diagnosed: videos
Stool or urine examination for eggs, serological tests, and imaging for organ involvement.
Treatment:
Antiparasitic medication is the main treatment, along with supportive care for complications.
Medications:
Praziquantel is the drug of choice, classified as an antiparasitic.
Prevalence:
How common the health condition is within a specific population.
Affects over 200 million people worldwide, particularly in sub-Saharan Africa.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Exposure to freshwater in endemic areas, lack of clean water access, poor sanitation.
Prognosis:
The expected outcome or course of the condition over time.
Good with early treatment; chronic cases may lead to long-term organ damage.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Liver fibrosis, bladder cancer, infertility, and increased risk of portal hypertension.
Tapeworm Infestation
Specialty: Infectious Diseases
Category: Parasitic Infections
Symptoms:
abdominal pain; nausea; diarrhea; weight loss; visible segments in stool
Root Cause:
Caused by ingestion of Taenia or other tapeworm species through undercooked meat or contaminated water.
How it's Diagnosed: videos
Stool sample analysis, serological tests for antibodies, and imaging for cysts.
Treatment:
Antiparasitic medication with symptomatic relief for gastrointestinal discomfort.
Medications:
Praziquantel and albendazole , classified as antiparasitics.
Prevalence:
How common the health condition is within a specific population.
Common in regions with poor food safety and hygiene; global cases vary by tapeworm species.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Eating undercooked or raw meat, poor hygiene, and exposure to contaminated water or food.
Prognosis:
The expected outcome or course of the condition over time.
Good with treatment, but untreated cases may lead to severe complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Intestinal blockage, cysticercosis, and neurocysticercosis (when cysts develop in the brain).
Toxocariasis
Specialty: Infectious Diseases
Category: Parasitic Infections
Symptoms:
fever; cough; abdominal pain; wheezing; blurred vision
Root Cause:
Caused by larvae of Toxocara species, transmitted via ingestion of soil contaminated with animal feces.
How it's Diagnosed: videos
Blood tests for antibodies, imaging for organ involvement, and clinical symptoms.
Treatment:
Antiparasitic drugs and corticosteroids for severe inflammation.
Medications:
Albendazole or mebendazole , both classified as antiparasitics.
Prevalence:
How common the health condition is within a specific population.
Found worldwide; higher prevalence in areas with poor sanitation.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Contact with contaminated soil, owning pets not dewormed regularly.
Prognosis:
The expected outcome or course of the condition over time.
Good with treatment; severe cases may result in long-term organ damage.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Ocular toxocariasis leading to vision loss, and visceral involvement causing organ damage.
Toxoplasmosis
Specialty: Infectious Diseases
Category: Parasitic Infections
Symptoms:
mild flu-like symptoms; swollen lymph nodes; muscle aches; fever
Root Cause:
Caused by Toxoplasma gondii, transmitted through undercooked meat, cat feces, or congenital infection.
How it's Diagnosed: videos
Blood tests for antibodies, PCR tests, and imaging for severe cases.
Treatment:
Treatment depends on severity and includes antiparasitic and antibiotic combinations.
Medications:
Pyrimethamine (antimalarial), sulfadiazine (antibiotic), and folinic acid for combination therapy.
Prevalence:
How common the health condition is within a specific population.
Approximately 30% of the global population is exposed; prevalence varies by region.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Contact with cat feces, undercooked meat, and weakened immune system.
Prognosis:
The expected outcome or course of the condition over time.
Good in healthy individuals; severe or congenital cases may lead to long-term complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Encephalitis, vision problems, and severe outcomes in immunocompromised individuals.
Toxoplasmosis (Organism-Specific Therapy)
Specialty: Infectious Diseases
Category: Parasitic Infections
Symptoms:
severe headaches; fever; confusion; seizures; blurry vision
Root Cause:
Severe infection by Toxoplasma gondii, often in immunocompromised patients such as those with HIV/AIDS.
How it's Diagnosed: videos
Blood tests for antibodies, imaging for CNS involvement, and clinical presentation.
Treatment:
High-dose antiparasitic and antibiotic combination tailored to the severity of infection.
Medications:
High-dose pyrimethamine (antimalarial) and sulfadiazine (antibiotic), along with leucovorin to prevent folate deficiency.
Prevalence:
How common the health condition is within a specific population.
Higher incidence in immunocompromised populations; overall prevalence similar to toxoplasmosis.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Weakened immune system, HIV/AIDS, organ transplantation.
Prognosis:
The expected outcome or course of the condition over time.
Guarded in immunocompromised individuals; depends on timely diagnosis and treatment.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Neurological damage, vision loss, and recurrence in untreated cases.
Trematode Infection
Specialty: Infectious Diseases
Category: Parasitic Infections
Symptoms:
fever; abdominal pain; diarrhea; weight loss; jaundice (in liver fluke infections); cough and chest pain (in lung fluke infections)
Root Cause:
Trematode infections are caused by parasitic flatworms (flukes) that invade the gastrointestinal tract, liver, lungs, or blood, depending on the species.
How it's Diagnosed: videos
Stool or urine examination to detect eggs, serologic tests, imaging (e.g., ultrasound, CT, or MRI) for organ involvement, and biopsy in some cases.
Treatment:
Antiparasitic medication, supportive care for symptoms, and in severe cases, surgical intervention for organ damage.
Medications:
Praziquantel , an antiparasitic medication that disrupts the parasite's membrane , is the primary treatment.
Prevalence:
How common the health condition is within a specific population.
Endemic in tropical and subtropical regions; common in areas with poor sanitation and close contact with freshwater sources.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Consumption of raw or undercooked freshwater fish, crabs, or plants; exposure to contaminated water; poor sanitation.
Prognosis:
The expected outcome or course of the condition over time.
Generally good with early diagnosis and treatment, but untreated cases can lead to severe organ damage and complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Liver fibrosis, portal hypertension, cholangiocarcinoma, pulmonary complications, and secondary bacterial infections.
Trichinosis (Trichinellosis)
Specialty: Infectious Diseases
Category: Parasitic Infections
Symptoms:
fever; muscle pain; swelling of the face (particularly around the eyes); gastrointestinal distress (diarrhea, nausea, vomiting); weakness
Root Cause:
Infection by Trichinella nematodes due to consumption of undercooked meat (especially pork or wild game) containing larval cysts.
How it's Diagnosed: videos
Blood tests showing elevated eosinophils, serologic tests, muscle biopsy (to detect larvae), and clinical history.
Treatment:
Antiparasitic medication combined with anti-inflammatory drugs to manage symptoms.
Medications:
Albendazole or mebendazole , both of which inhibit the parasite’s ability to absorb nutrients, along with corticosteroids for severe inflammation.
Prevalence:
How common the health condition is within a specific population.
Rare in developed countries due to improved food safety but more common in regions with traditional or underregulated meat preparation practices.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Eating raw or undercooked meat from pigs, bears, or other wild animals; poor meat inspection practices.
Prognosis:
The expected outcome or course of the condition over time.
Good with prompt treatment; severe cases may cause long-term muscle damage or complications if untreated.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Myocarditis, encephalitis, pneumonia, and chronic muscle pain.
Trichomoniasis
Specialty: Infectious Diseases
Category: Parasitic Infections
Symptoms:
vaginal discharge with an unpleasant odor (in women); itching or irritation of the genitals; painful urination; discomfort during intercourse; asymptomatic in many cases, especially in men
Root Cause:
Infection caused by the protozoan parasite Trichomonas vaginalis, primarily transmitted through sexual contact.
How it's Diagnosed: videos
Microscopic examination of vaginal or urethral secretions, nucleic acid amplification tests (NAATs), or culture tests.
Treatment:
Antiparasitic medication, and simultaneous treatment of sexual partners to prevent reinfection.
Medications:
Metronidazole or tinidazole , both of which are nitroimidazole-class antibiotics that disrupt the parasite’s DNA synthesis.
Prevalence:
How common the health condition is within a specific population.
A common sexually transmitted infection, affecting approximately 3.7 million people in the U.S. annually, with higher rates globally.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Unprotected sex, multiple sexual partners, previous or coexisting STIs, and poor sexual health practices.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with proper treatment, though reinfection is common without partner treatment.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Increased risk of HIV transmission, pregnancy complications (preterm birth, low birth weight), and pelvic inflammatory disease (rarely).
Tungiasis
Specialty: Infectious Diseases
Category: Parasitic Infections
Symptoms:
intense itching; pain at the site of infestation; black dot at the center of a swollen, inflamed lesion; secondary infections in severe cases; walking difficulty if located on feet
Root Cause:
Skin infestation by the sand flea (Tunga penetrans), which burrows into the skin, primarily in the feet, and causes inflammation.
How it's Diagnosed: videos
Clinical examination of characteristic lesions and history of travel or residence in endemic areas.
Treatment:
Removal of the flea under sterile conditions, topical antiseptics, and wound care to prevent secondary infections.
Medications:
Topical or oral antibiotics for secondary bacterial infections; antiparasitic agents (e.g., ivermectin ) are occasionally used in severe infestations.
Prevalence:
How common the health condition is within a specific population.
Common in rural and resource-poor areas of tropical and subtropical regions, especially in sub-Saharan Africa, the Caribbean, and South America.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Walking barefoot, living in areas with sandy soil, and poor sanitation.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with proper flea removal and wound care; untreated cases can lead to severe secondary complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Secondary bacterial infections, cellulitis, tetanus, and chronic ulcers.
Chancroid
Specialty: Infectious Diseases
Category: Sexually Transmitted Diseases
Symptoms:
painful genital ulcers; swollen and tender inguinal lymph nodes; discharge from ulcers; pain during urination
Root Cause:
Caused by Haemophilus ducreyi, a gram-negative bacterium that leads to ulcerative lesions.
How it's Diagnosed: videos
Clinical evaluation, culture or PCR of ulcer exudate, and exclusion of other ulcerative conditions like syphilis or herpes.
Treatment:
Antibiotic therapy, wound care, and drainage of abscessed lymph nodes if necessary.
Medications:
Azithromycin (macrolide antibiotic), Ceftriaxone (third-generation cephalosporin), Ciprofloxacin (fluoroquinolone), or Erythromycin (macrolide antibiotic).
Prevalence:
How common the health condition is within a specific population.
Rare in developed countries; endemic in parts of Africa, Asia, and the Caribbean.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Unprotected sexual contact, multiple sexual partners, and coexisting STDs.
Prognosis:
The expected outcome or course of the condition over time.
Effective treatment leads to resolution; delayed treatment may result in complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Phimosis, fistula formation, and superinfection; increased risk of HIV transmission.
Chlamydia (Chlamydial Genitourinary Infections)
Specialty: Infectious Diseases
Category: Sexually Transmitted Diseases
Symptoms:
asymptomatic in many cases; burning during urination; abnormal vaginal or penile discharge; lower abdominal pain; pain during intercourse; rectal pain or bleeding
Root Cause:
Infection with Chlamydia trachomatis, an obligate intracellular bacterium.
How it's Diagnosed: videos
NAAT (nucleic acid amplification test) of urine or swab specimens.
Treatment:
Antibiotic therapy and partner notification/treatment to prevent reinfection.
Medications:
Azithromycin (macrolide antibiotic) or Doxycycline (tetracycline antibiotic); alternatives include Erythromycin or Levofloxacin .
Prevalence:
How common the health condition is within a specific population.
Among the most common STDs globally, with millions of cases reported annually.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Unprotected sex, multiple sexual partners, young age, and previous STDs.
Prognosis:
The expected outcome or course of the condition over time.
Full recovery with treatment; untreated cases may lead to complications like pelvic inflammatory disease (PID).
Complications:
Additional problems or conditions that may arise as a result of the original condition.
PID, infertility, ectopic pregnancy, chronic pelvic pain, and neonatal infections in pregnant individuals.
Emergent Management of Gonorrhea
Specialty: Infectious Diseases
Category: Sexually Transmitted Diseases
Symptoms:
urethral discharge; painful urination; vaginal discharge; rectal pain; sore throat; pelvic or abdominal pain
Root Cause:
Infection with Neisseria gonorrhoeae, a gram-negative diplococcus.
How it's Diagnosed: videos
NAAT of urine, endocervical, or urethral swabs; culture for antibiotic susceptibility.
Treatment:
Immediate antibiotic therapy tailored to resistant strains.
Medications:
Ceftriaxone (third-generation cephalosporin) combined with Azithromycin or Doxycycline to cover potential coinfections.
Prevalence:
How common the health condition is within a specific population.
Common globally; increased antibiotic resistance is a growing concern.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Unprotected sex, multiple partners, MSM (men who have sex with men) population.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with prompt treatment; resistant strains may require alternative regimens.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Pelvic inflammatory disease, infertility, epididymitis, disseminated gonococcal infection (DGI).
Gonococcal Arthritis
Specialty: Infectious Diseases
Category: Sexually Transmitted Diseases
Symptoms:
joint pain; swelling in one or more joints; fever; skin lesions; painful or restricted joint movement
Root Cause:
Dissemination of Neisseria gonorrhoeae into the bloodstream, leading to septic arthritis.
How it's Diagnosed: videos
Synovial fluid analysis and culture, blood cultures, and NAAT for gonorrhea.
Treatment:
Antibiotics and joint drainage in severe cases.
Medications:
Ceftriaxone (third-generation cephalosporin) followed by oral therapy with Azithromycin or Doxycycline ; NSAIDs may be used for symptom relief.
Prevalence:
How common the health condition is within a specific population.
Rare but more common in sexually active young adults.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Untreated gonorrhea, multiple sexual partners, immunosuppression.
Prognosis:
The expected outcome or course of the condition over time.
Generally good with prompt treatment; delayed treatment may result in joint damage.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic arthritis, joint destruction, and systemic infection.
Gonorrhea
Specialty: Infectious Diseases
Category: Sexually Transmitted Diseases
Symptoms:
painful urination; abnormal discharge from the penis or vagina; rectal pain; sore throat; pelvic pain
Root Cause:
Caused by Neisseria gonorrhoeae, which infects mucous membranes.
How it's Diagnosed: videos
NAAT of urine, endocervical, or urethral swabs; culture for resistant strains.
Treatment:
Dual antibiotic therapy to address resistance.
Medications:
Ceftriaxone (third-generation cephalosporin) and Azithromycin (macrolide antibiotic); alternatives include Doxycycline .
Prevalence:
How common the health condition is within a specific population.
Very common, with millions of cases worldwide annually.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Unprotected sexual contact, multiple partners, previous STDs.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with treatment; untreated infections may cause severe complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
PID, infertility, epididymitis, DGI, neonatal conjunctivitis.
Herpetic Whitlow
Specialty: Infectious Diseases
Category: Viral Infections
Symptoms:
painful vesicles on fingers or hands; swelling; redness; fever; lymphadenopathy
Root Cause:
Infection with herpes simplex virus (HSV-1 or HSV-2) through direct contact with infected lesions.
How it's Diagnosed: videos
Clinical evaluation, Tzanck smear, or PCR testing.
Treatment:
Antiviral medications and supportive care.
Medications:
Acyclovir , Valacyclovir , or Famciclovir (antiviral agents).
Prevalence:
How common the health condition is within a specific population.
Common among healthcare workers and those exposed to oral or genital herpes.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Direct contact with HSV lesions, immunosuppression.
Prognosis:
The expected outcome or course of the condition over time.
Resolves with treatment; recurrence is possible.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Secondary bacterial infection, recurrence, pain, and difficulty in hand use.
Lymphogranuloma Venereum (LGV)
Specialty: Infectious Diseases
Category: Sexually Transmitted Diseases
Symptoms:
painless genital ulcer; swollen and painful lymph nodes; rectal pain or bleeding; fever; discharge
Root Cause:
Caused by invasive strains of Chlamydia trachomatis (L1, L2, L3 serovars).
How it's Diagnosed: videos
NAAT of lesion or rectal swabs, serologic tests.
Treatment:
Prolonged antibiotic therapy.
Medications:
Doxycycline (tetracycline antibiotic) for 21 days; Azithromycin as an alternative.
Prevalence:
How common the health condition is within a specific population.
Rare in developed countries; outbreaks in MSM populations in some areas.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Unprotected anal or genital contact, multiple partners.
Prognosis:
The expected outcome or course of the condition over time.
Good with treatment; untreated cases may lead to chronic complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic proctitis, strictures, elephantiasis of genitalia.
Syphilis
Specialty: Infectious Diseases
Category: Sexually Transmitted Diseases
Symptoms:
painless chancre (primary stage); rash on palms and soles (secondary stage); neurological symptoms (tertiary stage); fever; lymphadenopathy
Root Cause:
Caused by Treponema pallidum, a spirochete bacterium.
How it's Diagnosed: videos
Serologic tests (RPR, VDRL, FTA-ABS), darkfield microscopy.
Treatment:
Antibiotic therapy tailored to stage.
Medications:
Penicillin G (beta-lactam antibiotic), Doxycycline for penicillin-allergic individuals.
Prevalence:
How common the health condition is within a specific population.
Sporadic outbreaks globally; higher rates in MSM and coexisting HIV infections.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Unprotected sex, multiple partners, HIV coinfection.
Prognosis:
The expected outcome or course of the condition over time.
Good with early treatment; advanced stages can cause irreversible damage.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Cardiovascular and neurological damage, congenital syphilis.
Syphilis Organism-Specific Therapy
Specialty: Infectious Diseases
Category: Sexually Transmitted Diseases
Symptoms:
symptoms vary by stage
Root Cause:
Infection with Treponema pallidum causing systemic effects and requiring specific treatment tailored to the organism.
How it's Diagnosed: videos
Serologic tests (RPR, VDRL, FTA-ABS), darkfield microscopy for direct observation of spirochetes.
Treatment:
Penicillin-based therapy; specific duration and dosage depend on the disease stage.
Medications:
Benzathine Penicillin G (beta-lactam antibiotic); alternatives include Doxycycline (tetracycline antibiotic) for penicillin-allergic individuals.
Prevalence:
How common the health condition is within a specific population.
Common worldwide; disproportionately affects specific high-risk populations.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
High-risk sexual behavior, lack of screening, HIV co-infection.
Prognosis:
The expected outcome or course of the condition over time.
Curable with antibiotics; early treatment prevents complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Neurological sequelae, cardiovascular disease, congenital syphilis in newborns.
Ureaplasma Infection
Specialty: Infectious Diseases
Category: Genitourinary Infections
Symptoms:
asymptomatic in many cases; burning sensation during urination; pelvic or lower abdominal pain; abnormal discharge
Root Cause:
Infection caused by Ureaplasma urealyticum or Ureaplasma parvum, bacteria that lack a cell wall.
How it's Diagnosed: videos
PCR testing or culture of urine, vaginal, or urethral specimens.
Treatment:
Antibiotic therapy targeting atypical bacteria.
Medications:
Doxycycline (tetracycline antibiotic) or Azithromycin (macrolide antibiotic); alternatives include Fluoroquinolones like Levofloxacin .
Prevalence:
How common the health condition is within a specific population.
Common as part of normal genital flora but can cause symptomatic infections in certain cases.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Unprotected sex, multiple sexual partners, weakened immune system.
Prognosis:
The expected outcome or course of the condition over time.
Good with appropriate treatment; chronic or recurrent infections may occur.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Infertility, pelvic inflammatory disease (PID), preterm labor in pregnant individuals.
Anetoderma
Specialty: Infectious Diseases
Category: Skin and Soft-Tissue Infections
Symptoms:
localized areas of flaccid skin; soft patches or plaques with reduced elasticity; lesions that may appear wrinkled or saggy; absence of pain or itching
Root Cause:
Destruction or loss of elastic fibers in the dermis, often due to an immune or inflammatory process.
How it's Diagnosed: videos
Clinical examination, skin biopsy to confirm loss of elastic tissue, and possibly imaging for underlying systemic conditions.
Treatment:
Treatment focuses on addressing any underlying causes (e.g., infections, autoimmune conditions) and improving the appearance of lesions with procedures like laser therapy or topical treatments.
Medications:
No specific medications to reverse anetoderma, but antibiotics or anti-inflammatory drugs may be prescribed if an underlying cause such as infection or autoimmune disorder is identified.
Prevalence:
How common the health condition is within a specific population.
Rare; exact prevalence is unknown but is considered more frequent in individuals with autoimmune or systemic conditions.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
History of inflammatory or infectious skin diseases, autoimmune disorders, genetic predisposition.
Prognosis:
The expected outcome or course of the condition over time.
Typically benign and not life-threatening but can cause cosmetic concerns; prognosis depends on the management of underlying conditions.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Cosmetic disfigurement, psychological distress, and potential association with systemic conditions like lupus or syphilis.
Arcanobacterium Haemolyticum
Specialty: Infectious Diseases
Category: Skin and Soft-Tissue Infections
Symptoms:
pharyngitis with rash; sore throat; fever; skin lesions resembling scarlet fever; lymphadenopathy
Root Cause:
Bacterial infection caused by Arcanobacterium haemolyticum, often affecting the upper respiratory tract or skin.
How it's Diagnosed: videos
Throat swabs or skin lesion cultures; confirmed by microbiological identification of A. haemolyticum.
Treatment:
Antibiotics targeting A. haemolyticum, such as macrolides or penicillin derivatives.
Medications:
Erythromycin or clindamycin (macrolide class); penicillin (beta-lactam antibiotics) if the organism is susceptible.
Prevalence:
How common the health condition is within a specific population.
Uncommon; estimated to account for 0.5–2.5% of bacterial pharyngitis cases, especially in adolescents and young adults.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Adolescence, compromised immune system, close contact with infected individuals.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with appropriate antibiotic treatment; symptoms usually resolve without complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Rare but may include post-infectious skin eruptions, abscess formation, or septicemia.
Asymmetric Periflexural Exanthem of Childhood (APEC)
Specialty: Infectious Diseases
Category: Pediatric Exanthems
Symptoms:
unilateral rash in skin folds or flexural areas; erythematous or papular lesions; mild itching or discomfort; no systemic symptoms like fever
Root Cause:
Likely caused by a viral infection, although the exact pathogen is unknown. Immune response to an antigen may play a role.
How it's Diagnosed: videos
Clinical observation of the characteristic rash; no specific laboratory tests are needed.
Treatment:
Supportive care with topical emollients or antihistamines for itching; resolves spontaneously in 4–6 weeks.
Medications:
Antihistamines (e.g., cetirizine , loratadine for itching) and topical emollients (e.g., petroleum jelly, glycerin-based creams).
Prevalence:
How common the health condition is within a specific population.
Rare; affects children aged 1–5 years, with isolated case reports in the medical literature.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Viral infections, childhood age, exposure to viral antigens.
Prognosis:
The expected outcome or course of the condition over time.
Excellent; rash resolves without scarring or recurrence.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
No significant complications; mild itching may cause temporary discomfort.
Atypical Mycobacterial Diseases
Specialty: Infectious Diseases
Category: Mycobacterial Infections
Symptoms:
localized or systemic infection depending on the species; chronic skin ulcers; lymphadenitis; pulmonary symptoms in immunocompromised individuals
Root Cause:
Infection caused by non-tuberculous mycobacteria (NTM), such as Mycobacterium avium or Mycobacterium marinum. Often opportunistic infections.
How it's Diagnosed: videos
Culture and sensitivity testing of affected tissue, molecular methods like PCR, and imaging for systemic involvement.
Treatment:
Prolonged antibiotic regimens tailored to the specific mycobacterial species; surgical debridement in some cases.
Medications:
Clarithromycin (macrolide), rifampin (rifamycin class), ethambutol (antimycobacterial); combinations often used to prevent resistance.
Prevalence:
How common the health condition is within a specific population.
Rare but increasing in frequency due to immunosuppressed populations. Most common in individuals with underlying chronic lung diseases.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Immunosuppression (e.g., HIV/AIDS, chemotherapy), chronic lung conditions, exposure to contaminated water or soil.
Prognosis:
The expected outcome or course of the condition over time.
Variable; depends on the species and patient immune status. Often requires long-term treatment.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic infection, resistance to treatment, organ damage, dissemination in immunocompromised patients.
Bacillary Angiomatosis
Specialty: Infectious Diseases
Category: Infectious Vascular Lesions
Symptoms:
red, raised vascular skin lesions; fever; malaise; enlarged lymph nodes; systemic symptoms in severe cases
Root Cause:
Infection caused by Bartonella henselae or Bartonella quintana, often occurring in immunocompromised patients.
How it's Diagnosed: videos
Biopsy of lesions with histopathological examination and PCR to detect Bartonella species.
Treatment:
Prolonged antibiotic therapy with oral erythromycin or doxycycline; alternative therapies for resistant cases.
Medications:
Erythromycin (macrolide antibiotic) or doxycycline (tetracycline antibiotic); rifampin may be added for severe cases.
Prevalence:
How common the health condition is within a specific population.
Rare; primarily affects immunocompromised individuals such as those with HIV/AIDS.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Immunosuppression, exposure to cats (reservoir for Bartonella henselae), homelessness (linked to Bartonella quintana).
Prognosis:
The expected outcome or course of the condition over time.
Good with treatment; lesions resolve, and systemic symptoms improve, but untreated cases can lead to severe complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Dissemination to internal organs, bone infections, endocarditis, and death in untreated or severe cases.
Burn Wound Infections
Specialty: Infectious Diseases
Category: Skin and Soft-Tissue Infections
Symptoms:
redness and swelling around the burn site; increased pain; foul-smelling discharge; fever; delayed healing; formation of black or brown eschar
Root Cause:
Burn wounds compromise the skin barrier, allowing bacteria such as Pseudomonas aeruginosa, Staphylococcus aureus, or fungi to infect the tissue.
How it's Diagnosed: videos
Clinical examination of the wound, wound cultures, blood cultures (if systemic infection is suspected), imaging (to detect deeper infections).
Treatment:
Wound cleaning and debridement, antibiotics (based on culture results), supportive care such as fluid resuscitation, and sometimes surgical intervention.
Medications:
Antibiotics such as piperacillin-tazobactam (broad-spectrum penicillin), vancomycin (glycopeptide antibiotic for MRSA), or fluconazole (antifungal for fungal infections). Anti-inflammatory agents may also be used in severe cases.
Prevalence:
How common the health condition is within a specific population.
Common in patients with severe burns; infection rates are higher in hospitalized burn units.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Large burn area, deep burns, delay in wound care, poor hygiene, and comorbidities like diabetes or immunosuppression.
Prognosis:
The expected outcome or course of the condition over time.
Good with prompt treatment, though severe infections can lead to sepsis and mortality.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Sepsis, multi-organ failure, scar formation, and chronic wound infections.
Buruli Ulcer
Specialty: Infectious Diseases
Category: Skin and Soft-Tissue Infections
Symptoms:
painless nodule or swelling; progressive skin ulceration; necrosis of tissue; fever (in rare cases)
Root Cause:
Caused by Mycobacterium ulcerans, which produces mycolactone toxin leading to tissue destruction.
How it's Diagnosed: videos
Clinical examination, PCR to detect M. ulcerans, microscopy, or histopathology of biopsy specimens.
Treatment:
Combination antibiotic therapy (e.g., rifampin and clarithromycin), surgical debridement, and wound care.
Medications:
Rifampin (antimycobacterial) and clarithromycin (macrolide antibiotic); in severe cases, streptomycin (aminoglycoside).
Prevalence:
How common the health condition is within a specific population.
Endemic in tropical and subtropical regions, particularly in Africa.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Living in endemic areas, exposure to contaminated water sources, and poor wound care.
Prognosis:
The expected outcome or course of the condition over time.
Good if treated early; delays can result in severe deformities or disability.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic wounds, secondary infections, scarring, and functional impairment.
Cat Scratch Disease (Cat Scratch Fever)
Specialty: Infectious Diseases
Category: Skin and Soft-Tissue Infections
Symptoms:
swollen lymph nodes; fever; fatigue; headaches; blister or papule at the site of the scratch or bite
Root Cause:
Infection by Bartonella henselae, transmitted through cat scratches, bites, or flea contact.
How it's Diagnosed: videos
Serological tests, PCR, and clinical evaluation of symptoms.
Treatment:
Supportive care for mild cases; antibiotics for severe or systemic disease.
Medications:
Azithromycin (macrolide antibiotic) is the first-line treatment; doxycycline or rifampin may be used for severe cases.
Prevalence:
How common the health condition is within a specific population.
Relatively rare, most common in children and young adults.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Cat ownership, exposure to kittens or flea-infested cats.
Prognosis:
The expected outcome or course of the condition over time.
Excellent in most cases; symptoms typically resolve with or without treatment.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Rarely, encephalitis, endocarditis, or Parinaud's oculoglandular syndrome.
Cellulitis Empiric Therapy
Specialty: Infectious Diseases
Category: Skin and Soft-Tissue Infections
Symptoms:
red, swollen, tender skin; warmth in the affected area; fever; pain
Root Cause:
Empiric therapy targets likely bacterial pathogens such as Streptococcus pyogenes or Staphylococcus aureus before specific cultures are available.
How it's Diagnosed: videos
Clinical symptoms and risk factor evaluation; cultures may guide therapy later.
Treatment:
Antibiotics covering typical pathogens, adjusted based on clinical response.
Medications:
Cefazolin (beta-lactam antibiotic), clindamycin (lincosamide), or trimethoprim-sulfamethoxazole (sulfonamide) for MRSA coverage.
Prevalence:
How common the health condition is within a specific population.
Common in emergency and outpatient settings for initial cellulitis management.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Breaks in the skin, prior cellulitis, diabetes, and immunosuppression.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with appropriate empiric therapy; delays in treatment may lead to complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Abscess, sepsis, and necrotizing infections if initial therapy is ineffective.
Cellulitis Organism-Specific Therapy
Specialty: Infectious Diseases
Category: Skin and Soft-Tissue Infections
Symptoms:
localized redness and swelling; warmth; tenderness; fever
Root Cause:
Infection by specific pathogens identified through cultures, such as Group A Streptococcus or MRSA.
How it's Diagnosed: videos
Blood and wound cultures, guided by clinical findings.
Treatment:
Tailored antibiotic therapy based on culture results and antibiotic sensitivity.
Medications:
Penicillin for Group A Streptococcus; vancomycin or linezolid (oxazolidinone) for MRSA.
Prevalence:
How common the health condition is within a specific population.
Common when culture results confirm specific pathogens in cellulitis.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Wounds, immune compromise, and colonization by resistant bacteria.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with targeted therapy, reducing risk of resistance.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Inadequate coverage may lead to systemic spread, abscess formation, or chronic infection.
Clostridial Gas Gangrene
Specialty: Infectious Diseases
Category: Skin and Soft-Tissue Infections
Symptoms:
severe pain at infection site; swelling; blisters with clear or bloody fluid; crepitus; fever; tachycardia; shock in severe cases
Root Cause:
Toxins produced by Clostridium perfringens or related species destroy muscle tissue and produce gas.
How it's Diagnosed: videos
Clinical examination, imaging (X-ray/CT showing gas in tissues), Gram stain, and cultures.
Treatment:
Surgical debridement, antibiotics, and hyperbaric oxygen therapy.
Medications:
Penicillin (beta-lactam antibiotic) combined with clindamycin (to inhibit toxin production).
Prevalence:
How common the health condition is within a specific population.
Rare; typically associated with traumatic injuries, surgical wounds, or immunocompromised states.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Trauma, surgical wounds, diabetes, malignancy, and peripheral vascular disease.
Prognosis:
The expected outcome or course of the condition over time.
Poor if untreated; high mortality rate without aggressive management.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Sepsis, multi-organ failure, amputations, and death.
Cutaneous Protothecosis
Specialty: Infectious Diseases
Category: Skin and Soft-Tissue Infections
Symptoms:
painless nodules or plaques; ulcerations; chronic non-healing wounds
Root Cause:
Rare infection by Prototheca species (algae-like organisms) in immunocompromised individuals or following trauma.
How it's Diagnosed: videos
Microscopy, histopathology, and cultures of biopsy specimens.
Treatment:
Surgical excision and antifungal medications.
Medications:
Amphotericin B (polyene antifungal), itraconazole (azole antifungal).
Prevalence:
How common the health condition is within a specific population.
Rare, primarily in tropical climates and in patients with compromised immunity.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Immunosuppression, trauma, and exposure to contaminated water or soil.
Prognosis:
The expected outcome or course of the condition over time.
Good with timely treatment; chronic infection can occur if untreated.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Disseminated infection, particularly in immunosuppressed individuals.
Dermatitis Herpetiformis
Specialty: Infectious Diseases
Category: Skin and Soft-Tissue Infections
Symptoms:
intensely itchy blisters; burning sensation; symmetrical rash on elbows, knees, back, and scalp
Root Cause:
Autoimmune response to gluten in genetically predisposed individuals, associated with celiac disease.
How it's Diagnosed: videos
Skin biopsy with direct immunofluorescence, serological tests for anti-tissue transglutaminase antibodies.
Treatment:
Gluten-free diet and medications to control symptoms.
Medications:
Dapsone (anti-inflammatory and antimicrobial sulfone), gluten-free dietary adherence to prevent recurrence.
Prevalence:
How common the health condition is within a specific population.
Rare; more common in people of European descent and those with celiac disease.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Genetic predisposition (HLA-DQ2/DQ8), gluten consumption.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with strict gluten-free diet and dapsone treatment.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Increased risk of intestinal lymphoma if untreated or poorly managed.
Dermatologic Manifestations of Necrotizing Fasciitis
Specialty: Infectious Diseases
Category: Skin and Soft-Tissue Infections
Symptoms:
severe pain at the site of infection; rapidly spreading erythema; skin discoloration (red, purple, or black); blisters or bullae; fever; chills; fatigue; shock (in severe cases)
Root Cause:
Rapidly progressing infection of the fascia and subcutaneous tissues, often caused by bacteria like Streptococcus pyogenes or mixed organisms, resulting in extensive tissue necrosis.
How it's Diagnosed: videos
Based on clinical examination, imaging (MRI or CT to evaluate soft-tissue involvement), and surgical exploration; confirmed by microbiological culture and histopathology.
Treatment:
Immediate surgical debridement, broad-spectrum intravenous antibiotics, supportive care in an ICU setting, and in some cases, hyperbaric oxygen therapy.
Medications:
Treatment typically includes antibiotics such as broad-spectrum penicillins (e.g., piperacillin-tazobactam), carbapenems (e.g., meropenem ), and protein synthesis inhibitors (e.g., clindamycin , to reduce toxin production). Immunoglobulin therapy may be used in toxin-mediated cases.
Prevalence:
How common the health condition is within a specific population.
Rare but life-threatening; affects approximately 0.4 cases per 100,000 people annually.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Diabetes, peripheral vascular disease, recent surgery or trauma, immunosuppression, chronic illnesses, and intravenous drug use.
Prognosis:
The expected outcome or course of the condition over time.
Highly variable depending on the promptness of treatment; mortality rates range from 20–40% even with aggressive treatment.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Septic shock, multi-organ failure, amputations, extensive scarring, and disfigurement.
Dermatologic Manifestations of Staphylococcal Scalded Skin Syndrome
Specialty: Infectious Diseases
Category: Skin and Soft-Tissue Infections
Symptoms:
widespread skin redness; fragile blisters; peeling skin resembling burns; fever; irritability; painful skin
Root Cause:
Caused by exfoliative toxins from Staphylococcus aureus, leading to epidermal separation at the granular layer of the skin.
How it's Diagnosed: videos
Clinical presentation, biopsy of blister edge (showing intraepidermal cleavage), and microbiological testing of blood or other sources for Staphylococcus aureus.
Treatment:
Hospitalization with intravenous antibiotics, supportive care including fluid management, and wound care.
Medications:
Antibiotics such as nafcillin , oxacillin , or vancomycin (for MRSA coverage); clindamycin may also be used to inhibit toxin production.
Prevalence:
How common the health condition is within a specific population.
Rare; most common in neonates and young children.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Age (neonates and children), immunosuppression, renal failure, and colonization with toxin-producing S. aureus.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with prompt treatment; most children recover fully within 10 days.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Secondary bacterial infections, dehydration, and electrolyte imbalances.
Dermatologic Use of Botulinum Toxin
Specialty: Infectious Diseases
Category: Dermatologic Treatments
Sub-category: Cosmetic and Therapeutic Dermatology
Symptoms:
dynamic wrinkles (forehead lines, crow's feet); hyperhidrosis (excessive sweating); spasticity-related conditions; facial asymmetry due to muscle overactivity
Root Cause:
Overactivity of specific muscles or overactive sweat glands, addressed by the paralytic effects of botulinum toxin on neuromuscular junctions.
How it's Diagnosed: videos
Clinical evaluation of the condition requiring treatment (e.g., visible wrinkles or excessive sweating tests like starch-iodine for hyperhidrosis).
Treatment:
Intramuscular or intradermal injections of botulinum toxin; treatments need to be repeated every 3–6 months for sustained effects.
Medications:
Botulinum toxin type A (e.g., Botox, Dysport , Xeomin) or botulinum toxin type B (Myobloc ), classified as neurotoxins.
Prevalence:
How common the health condition is within a specific population.
Widely used in cosmetic dermatology; precise usage rates vary by region and indication.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
None specific for treatment, but patients with neuromuscular conditions (e.g., myasthenia gravis) may be at higher risk for side effects.
Prognosis:
The expected outcome or course of the condition over time.
Excellent for most cosmetic and therapeutic indications when administered by trained professionals.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Bruising, asymmetry, localized muscle weakness, or unintended spread of toxin causing temporary side effects.
Ecthyma
Specialty: Infectious Diseases
Category: Skin and Soft-Tissue Infections
Symptoms:
painful, crusted sores; ulcerations with purulent discharge; surrounding redness and inflammation
Root Cause:
A deeper infection of the skin caused by bacterial pathogens like Streptococcus pyogenes or Staphylococcus aureus.
How it's Diagnosed: videos
Clinical examination, and culture of wound exudate to identify causative bacteria.
Treatment:
Cleaning of lesions, topical and systemic antibiotics, and proper wound care.
Medications:
Oral antibiotics such as cephalexin or dicloxacillin (for MSSA coverage), and clindamycin or trimethoprim-sulfamethoxazole for suspected MRSA.
Prevalence:
How common the health condition is within a specific population.
More common in tropical or developing regions and among children.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Poor hygiene, minor skin trauma, immunosuppression, and warm, humid climates.
Prognosis:
The expected outcome or course of the condition over time.
Generally excellent with proper treatment, although scarring may occur in severe cases.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Cellulitis, deeper soft tissue infections, and post-infectious complications like glomerulonephritis (rare).
Ecthyma Gangrenosum
Specialty: Infectious Diseases
Category: Skin and Soft-Tissue Infections
Symptoms:
necrotic ulcers with a central black eschar; surrounding erythema; fever; sepsis in severe cases
Root Cause:
Caused by Pseudomonas aeruginosa or other gram-negative bacteria; often linked to bloodstream infections in immunocompromised patients.
How it's Diagnosed: videos
Clinical features, blood cultures, wound cultures, and imaging for extent of tissue involvement.
Treatment:
Aggressive systemic antibiotics and debridement if necessary.
Medications:
Antipseudomonal agents like piperacillin-tazobactam, ceftazidime , or carbapenems; combination therapy may be needed for severe cases.
Prevalence:
How common the health condition is within a specific population.
Rare; typically occurs in immunocompromised or critically ill patients.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Immunosuppression, neutropenia, hematologic malignancies, or prolonged hospitalization.
Prognosis:
The expected outcome or course of the condition over time.
Variable; high mortality rate in untreated cases or those with underlying sepsis.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Disseminated infection, sepsis, and organ failure.
Eosinophilic Folliculitis
Specialty: Infectious Diseases
Category: Inflammatory Skin Disorders
Symptoms:
itchy, red or pustular lesions around hair follicles; clusters of lesions on face, upper chest, back, and arms
Root Cause:
Inflammatory reaction around hair follicles, often associated with an increased eosinophilic response, common in HIV patients or those with immune dysregulation.
How it's Diagnosed: videos
Clinical features, biopsy showing eosinophilic infiltration, and ruling out other follicular infections.
Treatment:
Topical corticosteroids, oral antihistamines, or systemic immunosuppressive therapy in severe cases.
Medications:
Topical steroids (e.g., hydrocortisone or betamethasone ), oral antihistamines (e.g., loratadine ), and sometimes oral isotretinoin or itraconazole .
Prevalence:
How common the health condition is within a specific population.
Common in HIV-positive individuals; rare in the general population.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
HIV/AIDS, immunosuppression, or certain allergic predispositions.
Prognosis:
The expected outcome or course of the condition over time.
Good with treatment; lesions may recur if underlying immune condition persists.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Secondary bacterial infection and significant itching impacting quality of life.
Epidural Abscess
Specialty: Infectious Diseases
Category: Neurological and Infectious Diseases
Symptoms:
severe back pain; fever; neurological deficits (weakness, paralysis); bladder or bowel dysfunction
Root Cause:
Pus accumulation between the dura mater and the skull or spinal column, often caused by bacterial infections (Staphylococcus aureus is common).
How it's Diagnosed: videos
MRI with contrast, blood cultures, and sometimes biopsy of the abscess.
Treatment:
Immediate antibiotics and surgical drainage.
Medications:
Empirical antibiotics include vancomycin (for MRSA) plus ceftriaxone or cefepime (for gram-negative coverage).
Prevalence:
How common the health condition is within a specific population.
Rare; approximately 2–3 cases per 10,000 hospital admissions.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Recent spinal procedures, trauma, diabetes, IV drug use, and immunosuppression.
Prognosis:
The expected outcome or course of the condition over time.
Good with prompt treatment, though delayed diagnosis can lead to permanent neurological damage.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Paralysis, chronic pain, or death in severe cases.
Epidural Infections (Spinal Epidural Abscess) and Subdural Infections (Subdural Empyema)
Specialty: Infectious Diseases
Category: Skin and Soft-Tissue Infections
Symptoms:
fever; back pain; neurological deficits; headache; altered mental status; seizures; weakness or numbness
Root Cause:
Bacterial or fungal infection causing pus accumulation in the epidural or subdural space, often stemming from hematogenous spread, direct trauma, or nearby infections.
How it's Diagnosed: videos
MRI with gadolinium contrast, CT scan, blood cultures, lumbar puncture (caution due to potential complications).
Treatment:
Surgical drainage or decompression, intravenous antibiotics or antifungals, supportive care for any neurological impairments.
Medications:
Empirical antibiotic therapy typically includes vancomycin (a glycopeptide) combined with ceftriaxone (a third-generation cephalosporin). Antifungal agents like amphotericin B or fluconazole may be used for fungal infections.
Prevalence:
How common the health condition is within a specific population.
Rare; exact incidence is unclear but occurs more commonly in immunocompromised individuals or those with recent spinal procedures.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Diabetes, intravenous drug use, recent spinal surgery or trauma, immunosuppression, localized infections (e.g., abscess or osteomyelitis).
Prognosis:
The expected outcome or course of the condition over time.
Favorable with early detection and intervention; delayed treatment can result in permanent neurological deficits or death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Paralysis, septicemia, chronic pain, recurrent infections, and death if untreated.
Erysipeloid
Specialty: Infectious Diseases
Category: Skin and Soft-Tissue Infections
Symptoms:
painful, red, violaceous lesions on the hands or fingers; mild fever; joint pain
Root Cause:
Bacterial infection caused by Erysipelothrix rhusiopathiae, often from handling raw meat or fish.
How it's Diagnosed: videos
Clinical history, lesion swab or biopsy for culture, blood cultures in systemic cases.
Treatment:
Antibiotic therapy and protective measures to prevent recurrence.
Medications:
Penicillin (beta-lactam antibiotic); alternatives include doxycycline (tetracycline ) or ciprofloxacin (fluoroquinolone).
Prevalence:
How common the health condition is within a specific population.
Rare; occupational hazard for butchers, fish handlers, and veterinarians.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Occupational exposure to raw meat, fish, or animal products.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with treatment; self-limiting in mild cases.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Systemic infection, endocarditis.
Erythrasma
Specialty: Infectious Diseases
Category: Skin and Soft-Tissue Infections
Symptoms:
brownish-red, scaly patches; itching or mild irritation; common in skin folds like armpits, groin, or between toes
Root Cause:
Superficial skin infection caused by Corynebacterium minutissimum.
How it's Diagnosed: videos
Clinical examination with Wood's lamp (coral-red fluorescence), culture, or Gram staining.
Treatment:
Topical or oral antibiotics, good hygiene practices.
Medications:
Topical clindamycin (lincosamide) or erythromycin (macrolide); oral erythromycin or clarithromycin for extensive cases.
Prevalence:
How common the health condition is within a specific population.
Common, especially in warm, humid climates.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Diabetes, obesity, excessive sweating, poor hygiene.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with proper treatment.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Secondary bacterial infections.
Eumycetoma (Fungal Mycetoma)
Specialty: Infectious Diseases
Category: Skin and Soft-Tissue Infections
Symptoms:
painless swelling; nodules that may drain pus or grains; progressive destruction of soft tissue, bone, and skin
Root Cause:
Chronic fungal infection caused by various fungi (Madurella, Exophiala) entering through minor trauma.
How it's Diagnosed: videos
Histopathology, fungal culture, imaging (MRI or CT).
Treatment:
Antifungal therapy and surgical debridement or amputation in severe cases.
Medications:
Itraconazole (azole antifungal) or terbinafine (allylamine antifungal).
Prevalence:
How common the health condition is within a specific population.
Endemic in tropical and subtropical regions; common in agricultural workers.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Barefoot walking, farming, poor hygiene.
Prognosis:
The expected outcome or course of the condition over time.
Guarded; early treatment improves outcomes.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Severe deformity, disability, secondary bacterial infections.
Felon
Specialty: Infectious Diseases
Category: Skin and Soft-Tissue Infections
Symptoms:
severe pain in the fingertip; redness; swelling; pus accumulation; limited finger movement
Root Cause:
Bacterial infection of the fingertip pulp, commonly caused by Staphylococcus aureus.
How it's Diagnosed: videos
Clinical examination; ultrasound or MRI to confirm abscess formation.
Treatment:
Incision and drainage, antibiotics, pain management.
Medications:
Cephalexin (cephalosporin) or clindamycin (lincosamide); MRSA coverage with trimethoprim-sulfamethoxazole or doxycycline if indicated.
Prevalence:
How common the health condition is within a specific population.
Common, especially following minor finger injuries.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Nail biting, splinters, puncture wounds, diabetes.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with prompt treatment.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Osteomyelitis, tendon sheath infection, permanent deformity.
Gas Gangrene (Clostridial Myonecrosis)
Specialty: Infectious Diseases
Category: Skin and Soft-Tissue Infections
Symptoms:
severe pain at the site of infection; swelling; skin discoloration (purple or black); foul-smelling discharge; crepitus (crackling sound under the skin); fever; tachycardia; hypotension
Root Cause:
Caused by the rapid multiplication of Clostridium bacteria in oxygen-deprived tissues, leading to toxin production and tissue necrosis.
How it's Diagnosed: videos
Clinical examination, imaging (X-ray, CT, or MRI for gas in tissues), tissue culture, Gram stain, and blood tests (to assess infection severity).
Treatment:
Immediate surgical debridement, high-dose intravenous antibiotics, and hyperbaric oxygen therapy.
Medications:
Intravenous penicillin G (antibiotic) combined with clindamycin (protein synthesis inhibitor to reduce toxin production). Metronidazole can be used for patients allergic to penicillin.
Prevalence:
How common the health condition is within a specific population.
Rare; occurs mostly in traumatic injuries, surgical wounds, or underlying diseases like diabetes.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Traumatic injuries, surgical wounds, diabetes, peripheral vascular disease, immune suppression, intravenous drug use.
Prognosis:
The expected outcome or course of the condition over time.
Prompt treatment improves survival, but mortality remains high (up to 25-50%). Untreated cases are almost universally fatal.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Septic shock, organ failure, amputation, and death.
Gram-Negative Folliculitis
Specialty: Infectious Diseases
Category: Skin and Soft-Tissue Infections
Symptoms:
pustules around hair follicles; pain or tenderness; itching; redness; scarring in chronic cases
Root Cause:
Infection of hair follicles caused by Gram-negative bacteria (e.g., Klebsiella, Pseudomonas, or Proteus) often occurring after prolonged antibiotic treatment for acne.
How it's Diagnosed: videos
Clinical examination, bacterial culture from pustules, and Gram stain to identify the causative organism.
Treatment:
Discontinuation of broad-spectrum antibiotics, topical antiseptics, oral isotretinoin for severe cases, or specific antibiotics based on bacterial sensitivity.
Medications:
Oral ciprofloxacin (fluoroquinolone antibiotic), or trimethoprim-sulfamethoxazole (combination antibiotic).
Prevalence:
How common the health condition is within a specific population.
Rare, typically seen in individuals receiving prolonged antibiotic therapy for acne.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Prolonged antibiotic use, oily skin, immunosuppression, poor hygiene.
Prognosis:
The expected outcome or course of the condition over time.
Good with appropriate treatment; chronic cases may require isotretinoin for resolution.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic scarring, recurrence, or secondary infections.
Gram-Negative Toe Web Infection
Specialty: Infectious Diseases
Category: Skin and Soft-Tissue Infections
Symptoms:
macerated skin between toes; foul odor; redness; itching; pain; oozing lesions
Root Cause:
Caused by Gram-negative bacteria (Pseudomonas species or others) in moist and macerated environments, often secondary to fungal infections.
How it's Diagnosed: videos
Clinical presentation, skin culture, and Gram stain to identify the organism.
Treatment:
Topical antiseptics, systemic antibiotics for severe cases, and antifungal therapy if a fungal component is present.
Medications:
Topical silver sulfadiazine (antimicrobial), oral ciprofloxacin (fluoroquinolone), or gentamicin cream (aminoglycoside antibiotic).
Prevalence:
How common the health condition is within a specific population.
Common in individuals with athlete's foot or excessive foot moisture.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Diabetes, excessive sweating, tight footwear, poor foot hygiene, and fungal infections.
Prognosis:
The expected outcome or course of the condition over time.
Good with appropriate hygiene and treatment; recurrence possible without preventive measures.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Secondary bacterial infections, cellulitis, or chronic toe web infections.
Granuloma Inguinale (Donovanosis)
Specialty: Infectious Diseases
Category: Skin and Soft-Tissue Infections
Symptoms:
painless genital ulcers; beefy-red lesions; bleeding on contact; destructive ulceration in untreated cases
Root Cause:
Caused by Klebsiella granulomatis, a Gram-negative bacterium, leading to chronic granulomatous genital lesions.
How it's Diagnosed: videos
Identification of Donovan bodies in tissue smears or biopsies; PCR for confirmation.
Treatment:
Prolonged antibiotic therapy until the lesions completely heal.
Medications:
Oral doxycycline (tetracycline antibiotic) for 3 weeks or azithromycin (macrolide antibiotic) as an alternative.
Prevalence:
How common the health condition is within a specific population.
Rare, endemic in certain tropical and subtropical regions (e.g., India, South Africa, and Papua New Guinea).
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Unprotected sexual activity, living in endemic areas, and poor access to healthcare.
Prognosis:
The expected outcome or course of the condition over time.
Good with treatment, but recurrence can occur if treatment is incomplete.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Genital scarring, strictures, secondary infections, or spread to other body areas.
Hand Infections
Specialty: Infectious Diseases
Category: Skin and Soft-Tissue Infections
Symptoms:
swelling; pain; redness; limited range of motion; pus or discharge; fever in severe cases
Root Cause:
Can result from trauma, puncture wounds, animal bites, or underlying conditions, leading to bacterial colonization and abscess formation.
How it's Diagnosed: videos
Clinical examination, imaging for deep infections, and bacterial cultures from the infected site.
Treatment:
Incision and drainage of abscesses, antibiotics, and immobilization if needed.
Medications:
Oral amoxicillin-clavulanate (penicillin-class antibiotic with beta-lactamase inhibitor), or clindamycin for penicillin-allergic patients.
Prevalence:
How common the health condition is within a specific population.
Common; varies based on occupation and exposure to injury or pathogens.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Trauma, immune suppression, poor hygiene, and specific exposures (e.g., animal bites).
Prognosis:
The expected outcome or course of the condition over time.
Excellent with timely intervention; delayed treatment can lead to severe complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Tendon sheath infections, osteomyelitis, septic arthritis, or systemic sepsis.
Hand-Foot-and-Mouth Disease (HFMD)
Specialty: Infectious Diseases
Category: Skin and Soft-Tissue Infections
Symptoms:
fever; painful mouth sores; rash with blisters on hands, feet, and sometimes buttocks; irritability in infants and toddlers; loss of appetite
Root Cause:
Viral infection caused by Coxsackievirus or Enterovirus. It spreads through respiratory droplets, saliva, or contact with infected surfaces.
How it's Diagnosed: videos
Clinical examination of characteristic symptoms; rarely requires laboratory confirmation.
Treatment:
Supportive care, including hydration, pain relief, and fever management.
Medications:
No specific antiviral treatment; over-the-counter pain relievers (e.g., acetaminophen or ibuprofen ) are used for symptom relief.
Prevalence:
How common the health condition is within a specific population.
Common in children under five years; outbreaks in daycare centers and schools.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Close contact with infected individuals, poor hygiene, and crowded environments.
Prognosis:
The expected outcome or course of the condition over time.
Excellent; symptoms resolve within 7–10 days.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Rare but include viral meningitis, encephalitis, or dehydration due to difficulty swallowing.
Human Bites
Specialty: Infectious Diseases
Category: Skin and Soft-Tissue Infections
Symptoms:
redness; swelling; pain; fever; pus or discharge from the wound; localized warmth; difficulty moving affected area
Root Cause:
Human bites often introduce bacteria into the wound, including common pathogens like Streptococcus, Staphylococcus aureus, and anaerobic bacteria.
How it's Diagnosed: videos
Diagnosis is clinical, based on wound appearance and patient history. Imaging may be used to assess for deeper infections, and wound cultures help identify causative organisms.
Treatment:
Wound cleaning and debridement, empiric antibiotic therapy, and tetanus prophylaxis if indicated. Severe cases may require hospitalization and surgical intervention.
Medications:
Empiric antibiotics such as amoxicillin-clavulanate (a beta-lactam/beta-lactamase inhibitor), clindamycin (a lincosamide), or metronidazole (a nitroimidazole). Antibiotics should target common skin and oral flora.
Prevalence:
How common the health condition is within a specific population.
Human bites account for approximately 10–20% of all bite wounds treated in emergency settings.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Alcohol use, interpersonal violence, occupation (e.g., healthcare workers), delayed wound care, poor immune function.
Prognosis:
The expected outcome or course of the condition over time.
With prompt treatment, the prognosis is good. Delays can lead to complications such as cellulitis, abscess formation, or septicemia.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Cellulitis, abscess formation, osteomyelitis, septic arthritis, and sepsis.
Impetigo (Empiric Therapy)
Specialty: Infectious Diseases
Category: Skin and Soft-Tissue Infections
Symptoms:
honey-colored crusted lesions; red sores; itching; fluid-filled blisters that rupture easily
Root Cause:
Caused by Staphylococcus aureus or Streptococcus pyogenes, with superficial infection of the epidermis.
How it's Diagnosed: videos
Clinically diagnosed based on appearance. Bacterial cultures are rarely needed unless there is treatment failure.
Treatment:
Topical antibiotics for limited lesions and oral antibiotics for extensive disease or multiple patients in close contact.
Medications:
Mupirocin (topical antibiotic), retapamulin (topical antibiotic), cephalexin (oral beta-lactam), dicloxacillin (oral beta-lactam), clindamycin (oral lincosamide).
Prevalence:
How common the health condition is within a specific population.
Common in children, especially in warm, humid climates. Prevalence peaks in preschool and elementary-aged children.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Close contact in schools or sports, poor hygiene, pre-existing skin conditions (e.g., eczema).
Prognosis:
The expected outcome or course of the condition over time.
Excellent with treatment; lesions typically resolve in 1–2 weeks. Untreated cases may lead to post-streptococcal glomerulonephritis.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Post-streptococcal glomerulonephritis, cellulitis, and systemic infection in rare cases.
Impetigo (Organism-Specific Therapy)
Specialty: Infectious Diseases
Category: Skin and Soft-Tissue Infections
Symptoms:
honey-colored crusted lesions; red sores; itching; fluid-filled blisters that rupture easily
Root Cause:
Direct infection by S. aureus or S. pyogenes. Bacteria release toxins causing epidermal disruption.
How it's Diagnosed: videos
Bacterial cultures confirm the causative organism when empiric treatment fails or for outbreak control.
Treatment:
Narrow-spectrum antibiotics based on susceptibility testing.
Medications:
For S. pyogenes
Prevalence:
How common the health condition is within a specific population.
Same as empiric therapy.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Same as empiric therapy.
Prognosis:
The expected outcome or course of the condition over time.
Excellent if organism-specific therapy is matched.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Same as empiric therapy.
Lobomycosis
Specialty: Infectious Diseases
Category: Skin and Soft-Tissue Infections
Sub-category: Fungal Infections
Symptoms:
painless nodules or plaques; warty lesions; hypopigmented or atrophic scars; ulceration in advanced cases
Root Cause:
Chronic subcutaneous infection caused by Lacazia loboi, a slow-growing fungal pathogen.
How it's Diagnosed: videos
Clinical examination, histopathology with fungal staining, and microscopic visualization of yeast cells.
Treatment:
Wide surgical excision is often necessary. Antifungal treatments like itraconazole or amphotericin B may help prevent recurrence but are not consistently effective.
Medications:
Antifungal agents like itraconazole (triazole antifungal) or amphotericin B (polyene antifungal).
Prevalence:
How common the health condition is within a specific population.
Rare; reported primarily in tropical regions of South America.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Trauma in freshwater environments, poor immune function.
Prognosis:
The expected outcome or course of the condition over time.
Variable; recurrence is common, and untreated cases may progress slowly over years.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Disfigurement, secondary bacterial infections, and difficulty eradicating the infection completely.
Malakoplakia
Specialty: Infectious Diseases
Category: Skin and Soft-Tissue Infections
Symptoms:
soft plaques or nodules; lesions in skin or mucosa; fever; pain in affected areas
Root Cause:
Defective phagocytosis by macrophages leading to accumulation of bacteria and Michaelis-Gutmann bodies. Often associated with chronic bacterial infections (E. coli or Proteus mirabilis).
How it's Diagnosed: videos
Histological examination showing characteristic Michaelis-Gutmann bodies and tissue cultures.
Treatment:
Prolonged antibiotics tailored to bacterial cultures, surgical debridement, and addressing immunosuppression.
Medications:
Ciprofloxacin (fluoroquinolone), trimethoprim-sulfamethoxazole (folate synthesis inhibitor).
Prevalence:
How common the health condition is within a specific population.
Rare; reported more often in immunocompromised patients.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Immunosuppression, chronic infections, diabetes, and malignancy.
Prognosis:
The expected outcome or course of the condition over time.
Fair; recurrences are common without prolonged treatment.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic infection, disfigurement, and secondary complications due to bacterial persistence.
Malassezia (Pityrosporum) Folliculitis
Specialty: Infectious Diseases
Category: Skin and Soft-Tissue Infections
Sub-category: Fungal Infections
Symptoms:
itchy pustules on the chest, back, or face; redness around hair follicles; small bumps that resemble acne
Root Cause:
Overgrowth of Malassezia yeast, which thrives in oily skin or humid conditions, leading to follicular inflammation.
How it's Diagnosed: videos
Clinical diagnosis, KOH preparation, or fungal culture from affected skin.
Treatment:
Topical antifungal treatments or systemic antifungal medications for severe cases.
Medications:
Ketoconazole (topical or oral azole antifungal), fluconazole (oral azole antifungal), or selenium sulfide (topical).
Prevalence:
How common the health condition is within a specific population.
Common in adolescents and young adults, particularly in tropical climates.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Oily skin, hot and humid climates, use of oily products, immunosuppression.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with appropriate treatment; recurrences may occur without maintenance therapy.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Secondary bacterial infection or scarring if untreated.
Mediterranean Spotted Fever (Boutonneuse Fever)
Specialty: Infectious Diseases
Category: Skin and Soft-Tissue Infections
Symptoms:
fever; rash resembling red spots; eschar at the site of tick bite; headache; muscle pain; nausea
Root Cause:
Caused by Rickettsia conorii, transmitted through the bite of an infected tick.
How it's Diagnosed: videos
Clinical presentation, history of tick exposure, and confirmed through serological testing (indirect immunofluorescence or PCR).
Treatment:
Antibiotic therapy, primarily doxycycline.
Medications:
Doxycycline (a tetracycline antibiotic) is the primary treatment. Chloramphenicol can be used as an alternative in some cases.
Prevalence:
How common the health condition is within a specific population.
Occurs mainly in the Mediterranean region, Africa, and parts of Asia; seasonal prevalence tied to tick activity.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Exposure to tick-infested areas, outdoor activities, lack of tick prevention measures.
Prognosis:
The expected outcome or course of the condition over time.
Good with prompt treatment; untreated cases may result in severe complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Severe multi-organ failure, septic shock, myocarditis, and neurological symptoms in untreated cases.
Mycetoma
Specialty: Infectious Diseases
Category: Skin and Soft-Tissue Infections
Sub-category: Fungal Infections
Symptoms:
painless swelling of the affected area; multiple sinus tracts; drainage of pus or grains; deformity; restricted mobility in severe cases
Root Cause:
Chronic granulomatous infection caused by fungi (eumycetoma) or bacteria (actinomycetoma), often introduced through trauma.
How it's Diagnosed: videos
Clinical evaluation, microscopy of grains, culture, and imaging studies (X-ray, MRI).
Treatment:
Antifungal medications for eumycetoma (e.g., itraconazole) or antibiotics for actinomycetoma; advanced cases may require surgical debridement or amputation.
Medications:
Itraconazole (antifungal for eumycetoma), trimethoprim-sulfamethoxazole (antibiotic for actinomycetoma).
Prevalence:
How common the health condition is within a specific population.
Common in tropical and subtropical regions, particularly in rural agricultural workers.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Trauma to the skin, especially in endemic areas, lack of protective footwear.
Prognosis:
The expected outcome or course of the condition over time.
Variable; better outcomes with early treatment, but deformities and disability can occur in advanced cases.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic disability, severe deformity, secondary bacterial infections, amputation in severe cases.
Noncandidal Fungal Infections of the Mouth
Specialty: Infectious Diseases
Category: Fungal Infections
Sub-category: Oral Conditions
Symptoms:
painful oral lesions; difficulty swallowing; red or white patches; ulcers that don't heal
Root Cause:
Caused by fungi such as Aspergillus, Histoplasma, or Cryptococcus; often in immunocompromised individuals.
How it's Diagnosed: videos
Clinical examination, fungal culture, biopsy, and imaging.
Treatment:
Antifungal therapy tailored to the causative organism.
Medications:
Amphotericin B (polyenes), fluconazole or itraconazole (triazoles) depending on the fungus involved.
Prevalence:
How common the health condition is within a specific population.
Rare but occurs globally, especially in people with weakened immune systems.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Immunosuppression (e.g., HIV/AIDS, chemotherapy), prolonged corticosteroid use, organ transplantation.
Prognosis:
The expected outcome or course of the condition over time.
Good with early treatment, but severe cases may lead to systemic dissemination.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Disseminated fungal infection, airway obstruction, secondary bacterial infections.
Orf
Specialty: Infectious Diseases
Category: Skin and Soft-Tissue Infections
Sub-category: Viral Infections
Symptoms:
painful pustules or nodules on the hands or face; mild fever; swelling of nearby lymph nodes
Root Cause:
Zoonotic infection caused by Orf virus, transmitted from infected sheep or goats.
How it's Diagnosed: videos
Clinical appearance and history of animal exposure; PCR or electron microscopy for confirmation.
Treatment:
Supportive care; antiviral medications like cidofovir in severe cases.
Medications:
No specific antiviral; cidofovir may be used off-label in severe infections.
Prevalence:
How common the health condition is within a specific population.
Common among livestock handlers; endemic in regions with sheep and goat farming.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Direct contact with infected animals, lack of protective gloves.
Prognosis:
The expected outcome or course of the condition over time.
Self-limiting in most cases, resolving in 4–6 weeks.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Rare secondary bacterial infections or widespread lesions in immunocompromised patients.
Pediculosis and Pthiriasis (Lice Infestation)
Specialty: Infectious Diseases
Category: Parasitic Infections
Symptoms:
itching; visible lice or eggs (nits) on hair or skin; red bite marks; secondary bacterial infections from scratching
Root Cause:
Infestation by lice (Pediculus humanus capitis, Pediculus humanus corporis, or Pthirus pubis), which feed on human blood.
How it's Diagnosed: videos
Visual identification of lice or eggs with a magnifying glass or comb.
Treatment:
Topical insecticides, manual removal, and environmental decontamination.
Medications:
Permethrin (topical insecticide), ivermectin (oral or topical antiparasitic), malathion lotion.
Prevalence:
How common the health condition is within a specific population.
Common globally, especially in crowded or unsanitary living conditions; head lice are prevalent in school-aged children.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Close contact with infested individuals, sharing personal items, overcrowded living conditions.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with appropriate treatment and environmental control.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Secondary bacterial infections (e.g., impetigo), chronic scratching leading to dermatitis.
Piedra
Specialty: Infectious Diseases
Category: Fungal Infections
Sub-category: Hair Conditions
Symptoms:
hard nodules on hair shafts; hair brittleness; hair breakage
Root Cause:
Infection of the hair shaft by fungi; Trichosporon causes white piedra, and Piedraia hortae causes black piedra.
How it's Diagnosed: videos
Microscopic examination of hair shafts, fungal culture.
Treatment:
Hair shaving, antifungal shampoos, and oral antifungal medications in persistent cases.
Medications:
Ketoconazole shampoo (topical antifungal), itraconazole or terbinafine (oral antifungals in severe cases).
Prevalence:
How common the health condition is within a specific population.
Rare; more common in tropical and subtropical regions.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Poor hygiene, warm and humid climates, sharing hair care tools.
Prognosis:
The expected outcome or course of the condition over time.
Good with appropriate treatment, but recurrence is possible if predisposing factors persist.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Cosmetic concerns and hair damage.
Pinta
Specialty: Infectious Diseases
Category: Bacterial Infections
Sub-category: Treponematoses
Symptoms:
skin lesions that progress from red to blue, then to depigmented patches; itching; cosmetic skin changes
Root Cause:
Chronic skin infection caused by Treponema carateum.
How it's Diagnosed: videos
Clinical examination, serological tests (e.g., VDRL, RPR), and dark-field microscopy.
Treatment:
Antibiotic therapy with penicillin.
Medications:
Benzathine penicillin G (antibiotic), doxycycline as an alternative for penicillin-allergic patients.
Prevalence:
How common the health condition is within a specific population.
Endemic in rural areas of Central and South America.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Close contact with infected individuals, poor hygiene, living in endemic regions.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with treatment; cosmetic changes may persist if depigmentation is extensive.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic skin discoloration and social stigma in untreated cases.
Pitted Keratolysis
Specialty: Infectious Diseases
Category: Skin and Soft-Tissue Infections
Symptoms:
foul odor from the feet; small crater-like pits on the soles; white, macerated skin; mild itching or burning
Root Cause:
Bacterial infection caused by Kytococcus sedentarius, Dermatophilus congolensis, or other corynebacteria due to excessive moisture and sweat retention in footwear.
How it's Diagnosed: videos
Clinical examination based on characteristic pits and odor; occasionally, bacterial culture or Wood's lamp examination may be used.
Treatment:
Keeping feet dry, antibacterial creams or solutions, and proper hygiene practices.
Medications:
Topical antibiotics such as clindamycin (lincosamide class), erythromycin (macrolide class), or mupirocin (antibacterial). Occasionally benzoyl peroxide (antibacterial and keratolytic agent) is used.
Prevalence:
How common the health condition is within a specific population.
Common among individuals in hot, humid climates and those wearing occlusive footwear for prolonged periods.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Excessive sweating (hyperhidrosis), poor foot hygiene, prolonged use of occlusive footwear.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with appropriate treatment; resolves within weeks to months if hygiene and dryness are maintained.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Rare but may include secondary bacterial infections or recurrent episodes if predisposing factors persist.
Pseudomonas Folliculitis
Specialty: Infectious Diseases
Category: Skin and Soft-Tissue Infections
Symptoms:
red, itchy, or tender pustules; rash primarily on water-exposed areas; low-grade fever (rare); burning sensation
Root Cause:
Infection of hair follicles caused by Pseudomonas aeruginosa, often from contaminated water in hot tubs, pools, or spas.
How it's Diagnosed: videos
Clinical examination; confirmed by bacterial culture of the lesions if necessary.
Treatment:
Resolves spontaneously in mild cases; topical or systemic antibiotics in severe or persistent cases.
Medications:
Ciprofloxacin (fluoroquinolone class) for systemic infection; acetic acid or polymyxin B (antibacterial solutions) for topical treatment.
Prevalence:
How common the health condition is within a specific population.
Common among individuals frequently using improperly maintained hot tubs or pools.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Exposure to contaminated water, compromised skin barrier, shaving or waxing.
Prognosis:
The expected outcome or course of the condition over time.
Excellent; most cases resolve without complications in 7–14 days.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Rarely, abscess formation or systemic infection in immunocompromised individuals.
Pustular Psoriasis
Specialty: Infectious Diseases
Category: Immune-Mediated Skin Disorders
Sub-category: Psoriasis Subtypes
Symptoms:
red, inflamed skin with white pustules; fever or chills; fatigue; itching or burning
Root Cause:
Dysregulated immune response causing epidermal hyperproliferation and inflammation.
How it's Diagnosed: videos
Clinical evaluation; confirmed by skin biopsy showing neutrophilic infiltration.
Treatment:
Immunosuppressants, topical corticosteroids, and systemic biologics.
Medications:
Methotrexate (antimetabolite), cyclosporine (calcineurin inhibitor), biologics like adalimumab or infliximab (TNF-alpha inhibitors). Topical treatments include clobetasol (steroid).
Prevalence:
How common the health condition is within a specific population.
Rare; less than 1% of psoriasis cases.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Family history, infections, stress, abrupt discontinuation of systemic steroids.
Prognosis:
The expected outcome or course of the condition over time.
Variable; may lead to remission with treatment, but frequent relapses occur.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Severe forms may cause erythroderma, secondary infections, or systemic inflammation.
Scarlet Fever
Specialty: Infectious Diseases
Category: Bacterial Infections
Symptoms:
fever; red, sandpaper-like rash; sore throat; strawberry tongue; swollen lymph nodes
Root Cause:
Infection with Streptococcus pyogenes producing erythrogenic toxin.
How it's Diagnosed: videos
Clinical features; throat culture or rapid strep test to confirm streptococcal infection.
Treatment:
Antibiotics to eradicate the bacteria and prevent complications.
Medications:
Penicillin or amoxicillin (beta-lactam antibiotics); azithromycin (macrolide) for penicillin-allergic individuals.
Prevalence:
How common the health condition is within a specific population.
Less common in developed countries due to antibiotic use; outbreaks still occur.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Recent strep throat infection, close contact with infected individuals.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with antibiotic treatment; resolves within 1–2 weeks.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Rheumatic fever, post-streptococcal glomerulonephritis, or abscess formation.
Tinea Barbae
Specialty: Infectious Diseases
Category: Skin and Soft-Tissue Infections
Symptoms:
red, scaly, or inflamed patches on the beard or facial area; hair loss in the affected area; pustules or abscess formation; itching or burning sensation
Root Cause:
Fungal infection caused by dermatophytes (Trichophyton or Microsporum species) affecting the hair follicles in the beard area.
How it's Diagnosed: videos
Clinical examination, fungal culture, or microscopy with potassium hydroxide (KOH) preparation.
Treatment:
Systemic antifungal medications are the main treatment, often combined with topical antifungal agents.
Medications:
Oral antifungals like terbinafine (allylamine class) or itraconazole (triazole antifungal class) are prescribed. Topical antifungals (e.g., clotrimazole , miconazole ) may be adjunctive.
Prevalence:
How common the health condition is within a specific population.
Relatively uncommon; more prevalent in rural areas with exposure to infected animals.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Close contact with infected animals, poor hygiene, and warm, humid environments.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with appropriate treatment; resolves without scarring in most cases.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Secondary bacterial infections, scarring, or chronic inflammation if untreated.
Tinea Corporis
Specialty: Infectious Diseases
Category: Skin and Soft-Tissue Infections
Symptoms:
ring-shaped, red, scaly patches on the skin; itching; central clearing with an active, raised border
Root Cause:
Superficial fungal infection of the skin caused by dermatophytes (Trichophyton or Microsporum species).
How it's Diagnosed: videos
Clinical examination, KOH microscopy, or fungal culture.
Treatment:
Topical or systemic antifungal therapy.
Medications:
Topical antifungals like clotrimazole (imidazole class) or terbinafine (allylamine class); oral antifungals such as fluconazole (triazole antifungal) may be used for extensive cases.
Prevalence:
How common the health condition is within a specific population.
Common worldwide; more prevalent in warm, humid climates.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Warm climates, close contact with infected individuals, poor hygiene.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with treatment; resolves within weeks.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic infection, secondary bacterial infections.
Tinea Cruris
Specialty: Infectious Diseases
Category: Skin and Soft-Tissue Infections
Symptoms:
itchy, red, scaly patches in the groin area; raised edges with central clearing; skin irritation and burning sensation
Root Cause:
Fungal infection of the groin area caused by dermatophytes (commonly Trichophyton rubrum).
How it's Diagnosed: videos
Clinical evaluation, KOH microscopy, or fungal culture.
Treatment:
Topical antifungal medications; oral antifungals for severe or recurrent cases.
Medications:
Topical clotrimazole (imidazole) or terbinafine (allylamine); oral fluconazole or itraconazole for severe infections.
Prevalence:
How common the health condition is within a specific population.
Common among adults; higher prevalence in athletes and individuals in humid environments.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Excessive sweating, obesity, tight clothing, warm climates.
Prognosis:
The expected outcome or course of the condition over time.
Very good with treatment; recurrence is possible without preventive measures.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Spread to adjacent areas, secondary bacterial infections.
Tinea in Emergency Medicine
Specialty: Infectious Diseases
Category: Skin and Soft-Tissue Infections
Symptoms:
localized skin scaling; itching; erythematous or hyperpigmented patches
Root Cause:
Acute or chronic fungal infection of the skin caused by dermatophytes.
How it's Diagnosed: videos
Clinical assessment, microscopy (KOH prep), and culture.
Treatment:
Depends on the type and severity; topical or systemic antifungal therapy.
Medications:
Terbinafine or clotrimazole for topical use; oral itraconazole or griseofulvin for systemic treatment.
Prevalence:
How common the health condition is within a specific population.
Widespread across different age groups; incidence depends on region and hygiene standards.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Poor hygiene, warm environments, immunosuppression.
Prognosis:
The expected outcome or course of the condition over time.
Good with treatment; chronicity is possible without adherence.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Disseminated infection in immunocompromised individuals.
Tinea Nigra
Specialty: Infectious Diseases
Category: Skin and Soft-Tissue Infections
Symptoms:
dark brown to black macules on palms or soles; non-scaly lesions; asymptomatic
Root Cause:
Superficial fungal infection caused by Hortaea werneckii.
How it's Diagnosed: videos
Clinical evaluation, KOH microscopy, and fungal culture.
Treatment:
Topical antifungal agents.
Medications:
Topical miconazole (imidazole class) or terbinafine (allylamine class).
Prevalence:
How common the health condition is within a specific population.
Rare; more common in tropical and subtropical regions.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Warm, humid environments; exposure to contaminated soil or vegetation.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with treatment; responds well to topical therapy.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
None reported with proper treatment.
Tinea Pedis
Specialty: Infectious Diseases
Category: Skin and Soft-Tissue Infections
Symptoms:
itchy, scaly skin between toes; redness; fissures or peeling; blisters on the feet
Root Cause:
Fungal infection of the feet caused by dermatophytes, commonly Trichophyton rubrum.
How it's Diagnosed: videos
Clinical observation, KOH microscopy, or culture.
Treatment:
Topical antifungal agents for mild cases; oral therapy for severe infections.
Medications:
Topical terbinafine or clotrimazole ; oral itraconazole or fluconazole for extensive infections.
Prevalence:
How common the health condition is within a specific population.
Common worldwide; affects up to 10% of the population.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Use of occlusive footwear, sweating, communal showers or pools.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with treatment; recurrence is possible.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Secondary bacterial infections, chronicity.
Tinea Versicolor
Specialty: Infectious Diseases
Category: Skin and Soft-Tissue Infections
Symptoms:
hypopigmented or hyperpigmented patches on the trunk and arms; mild scaling; itching
Root Cause:
Superficial fungal infection caused by Malassezia species.
How it's Diagnosed: videos
Clinical examination, KOH microscopy, or Wood's lamp test.
Treatment:
Topical or systemic antifungal therapy.
Medications:
Topical ketoconazole (imidazole) or selenium sulfide lotion; oral itraconazole for extensive cases.
Prevalence:
How common the health condition is within a specific population.
Common in tropical regions; affects all age groups.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Oily skin, humid climates, immunosuppression.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with treatment; pigmentation changes may persist temporarily.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Recurrence is common.
Transient Neonatal Pustular Melanosis
Specialty: Infectious Diseases
Category: Skin and Soft-Tissue Infections
Symptoms:
pustules on the skin; hyperpigmented macules after pustules rupture; typically non-itchy and non-tender
Root Cause:
Benign neonatal skin condition of unknown etiology, often seen in full-term infants.
How it's Diagnosed: videos
Clinical examination, cytology of pustular fluid showing neutrophils without bacteria.
Treatment:
No treatment required; self-resolving condition.
Medications:
None needed.
Prevalence:
How common the health condition is within a specific population.
Relatively common; varies by ethnic group (higher prevalence in Black neonates).
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
None specific; normal physiological condition.
Prognosis:
The expected outcome or course of the condition over time.
Excellent; resolves without intervention.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
None.
Trichomycosis Axillaris
Specialty: Infectious Diseases
Category: Skin and Soft-Tissue Infections
Symptoms:
yellow, black, or red nodules on hair shafts in the axilla; foul odor; excessive sweating
Root Cause:
Bacterial infection of the hair shaft caused by Corynebacterium species.
How it's Diagnosed: videos
Clinical appearance, microscopic examination of hair shafts.
Treatment:
Good hygiene, shaving the affected area, and topical antibacterial agents.
Medications:
Topical clindamycin (lincosamide antibiotic) or benzoyl peroxide.
Prevalence:
How common the health condition is within a specific population.
Common in warm, humid climates.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Poor hygiene, hyperhidrosis, warm climates.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with treatment and hygiene measures.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Persistent odor or recurrence if untreated.
Trichomycosis Pubis
Specialty: Infectious Diseases
Category: Skin and Soft-Tissue Infections
Symptoms:
colored concretions (yellow, black, or red) on pubic hair; foul odor; sweat-stained areas
Root Cause:
Bacterial infection of pubic hair by Corynebacterium species.
How it's Diagnosed: videos
Visual inspection and microscopic examination.
Treatment:
Shaving the affected area and using topical antibacterial agents.
Medications:
Topical clindamycin or benzoyl peroxide (antibacterial agents).
Prevalence:
How common the health condition is within a specific population.
Less common than axillary form; associated with warm climates and hygiene practices.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Poor hygiene, hyperhidrosis, tight clothing.
Prognosis:
The expected outcome or course of the condition over time.
Very good with treatment; recurrence possible without proper hygiene.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Persistent discomfort or odor.
Wound Infection
Specialty: Infectious Diseases
Category: Skin and Soft-Tissue Infections
Symptoms:
redness, swelling, and warmth around the wound; pain; purulent discharge; fever or systemic symptoms in severe cases
Root Cause:
Bacterial contamination of a wound leading to inflammation and potential tissue damage; common pathogens include Staphylococcus aureus and Streptococcus species.
How it's Diagnosed: videos
Clinical evaluation, wound culture, blood tests in severe cases.
Treatment:
Cleaning and debridement of the wound, antimicrobial therapy as needed.
Medications:
Antibiotics like amoxicillin-clavulanate (beta-lactam class) or clindamycin (lincosamide class). Severe infections may require vancomycin or piperacillin-tazobactam.
Prevalence:
How common the health condition is within a specific population.
Common; varies with wound type and hygiene.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Poor wound care, immunosuppression, diabetes, contaminated wounds.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with early intervention; delayed treatment may lead to complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Cellulitis, abscess formation, sepsis, or necrotizing fasciitis.
Bacterial Infections and Pregnancy
Specialty: Infectious Diseases
Category: Special Topics
Symptoms:
fever; abdominal pain; vaginal discharge; preterm labor; maternal sepsis; fetal distress
Root Cause:
Bacterial infections in pregnancy can result from common pathogens like Group B Streptococcus, Listeria, E. coli, or Chlamydia, affecting maternal and fetal health.
How it's Diagnosed: videos
Diagnosis involves clinical evaluation, culture tests (blood, urine, vaginal swabs), imaging (if necessary), and specific tests for pathogens (PCR or antigen-based tests).
Treatment:
Treatment includes targeted antibiotic therapy, managing maternal symptoms, and monitoring fetal health. Hospitalization may be required for severe cases.
Medications:
Antibiotics such as amoxicillin , azithromycin , ceftriaxone , or penicillin are commonly prescribed. These belong to beta-lactam antibiotics, macrolides, or cephalosporins, ensuring safety for the mother and fetus.
Prevalence:
How common the health condition is within a specific population.
Approximately 10-30% of pregnant women may be carriers of Group B Streptococcus; other infections like Listeria are less common but significant due to potential complications.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
History of preterm delivery, poor hygiene, lack of prenatal care, unpasteurized food consumption, and untreated infections.
Prognosis:
The expected outcome or course of the condition over time.
With early diagnosis and appropriate treatment, outcomes for mother and baby are generally favorable. Untreated infections can lead to severe complications, including sepsis or neonatal mortality.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Preterm labor, miscarriage, neonatal sepsis, maternal sepsis, or long-term developmental issues in the infant.
Chronic Fatigue Syndrome (Myalgic Encephalomyelitis)
Specialty: Infectious Diseases
Category: Chronic Conditions
Sub-category: Neurological and Immunological Disorders
Symptoms:
persistent fatigue; muscle and joint pain; headaches; memory issues; unrefreshing sleep; post-exertional malaise
Root Cause:
The cause is unclear but may involve immune dysfunction, viral triggers, hormonal imbalances, and mitochondrial dysfunction.
How it's Diagnosed: videos
Based on clinical criteria, excluding other conditions through tests like blood panels, thyroid function tests, and brain imaging when needed.
Treatment:
Treatment focuses on symptom management using a multidisciplinary approach, including cognitive behavioral therapy, graded exercise therapy, and lifestyle adjustments.
Medications:
Pain relievers (NSAIDs), antidepressants (SSRIs or SNRIs), and sleep aids like amitriptyline . These belong to analgesics, psychotropics, and sedatives.
Prevalence:
How common the health condition is within a specific population.
Affects about 1-2 million people in the U.S., with women more commonly affected.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Viral infections, stress, hormonal changes, genetic predisposition, and trauma.
Prognosis:
The expected outcome or course of the condition over time.
Prognosis varies; some individuals experience improvement, but others may have chronic symptoms requiring lifelong management.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Social isolation, depression, and an inability to perform daily tasks or maintain employment.
Tick-Borne Diseases
Specialty: Infectious Diseases
Category: Infectious Diseases
Sub-category: Vector-Borne Diseases
Symptoms:
fever; rash; joint pain; muscle aches; neurological symptoms like headaches or paralysis; fatigue
Root Cause:
Diseases transmitted by tick bites, including Lyme disease, Rocky Mountain spotted fever, and Babesiosis, caused by bacteria, viruses, or protozoa.
How it's Diagnosed: videos
Based on history of tick exposure, clinical signs, serological tests (e.g., ELISA, Western blot), or PCR testing.
Treatment:
Antibiotics such as doxycycline, amoxicillin, or ceftriaxone for bacterial infections. Supportive care for viral causes.
Medications:
Antibiotics (doxycycline for most tick-borne bacterial diseases; ceftriaxone for severe cases like neuroborreliosis). Antimalarials (atovaquone for Babesiosis). These are antimicrobial agents.
Prevalence:
How common the health condition is within a specific population.
Incidence varies by region; Lyme disease affects approximately 300,000 people annually in the U.S.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Exposure to wooded or grassy areas, improper clothing, lack of tick repellents, and outdoor activities.
Prognosis:
The expected outcome or course of the condition over time.
Early treatment results in excellent outcomes, but delayed diagnosis can lead to chronic symptoms or severe complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic fatigue, arthritis, neurological disorders, or cardiovascular issues in untreated cases.
Adenovirus
Specialty: Infectious Diseases
Category: Viral Infections
Symptoms:
fever; sore throat; conjunctivitis (pink eye); respiratory symptoms (cough, runny nose); gastrointestinal symptoms (diarrhea, vomiting); urinary symptoms in severe cases (hemorrhagic cystitis)
Root Cause:
Caused by adenoviruses, which are non-enveloped DNA viruses that can infect various tissues, leading to respiratory, gastrointestinal, and ocular symptoms.
How it's Diagnosed: videos
Clinical evaluation, PCR testing of bodily fluids (e.g., throat swabs, stool samples), viral culture, or antigen detection.
Treatment:
Supportive care, including hydration, antipyretics for fever, and symptomatic management. Severe cases may require antiviral therapy.
Medications:
In severe cases, cidofovir (a nucleotide analog antiviral) may be used. This medication is classified as an antiviral agent.
Prevalence:
How common the health condition is within a specific population.
Common; adenovirus infections are widespread and account for approximately 5-10% of respiratory infections in children and various other conditions in adults.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Young age, immunosuppression, crowded living conditions, close contact with infected individuals.
Prognosis:
The expected outcome or course of the condition over time.
Generally good for healthy individuals; immunocompromised patients are at higher risk for severe complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Bronchitis, pneumonia, encephalitis, keratoconjunctivitis, and disseminated infection in immunocompromised individuals.
Arenaviruses
Specialty: Infectious Diseases
Category: Viral Infections
Symptoms:
fever; headache; myalgia; nausea; vomiting; hemorrhagic symptoms in severe cases
Root Cause:
Caused by arenaviruses, which are RNA viruses transmitted through rodent hosts. Some species can cause hemorrhagic fevers.
How it's Diagnosed: videos
PCR testing, serological testing, and virus isolation in specialized laboratories.
Treatment:
Supportive care; ribavirin (an antiviral medication) may be used in some cases.
Medications:
Ribavirin , an antiviral agent classified as a nucleoside analog.
Prevalence:
How common the health condition is within a specific population.
Rare but can occur in endemic regions where rodent reservoirs are prevalent.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Exposure to infected rodents, living in endemic areas, poor sanitation.
Prognosis:
The expected outcome or course of the condition over time.
Depends on the specific arenavirus; Lassa fever has a case fatality rate of 1-15%. Early treatment improves outcomes.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Hemorrhagic fever, multi-organ failure, and death in severe cases.
Avian Influenza (Bird Flu)
Specialty: Infectious Diseases
Category: Viral Infections
Symptoms:
high fever; cough; difficulty breathing; muscle aches; conjunctivitis; diarrhea; neurological symptoms in severe cases
Root Cause:
Caused by avian influenza viruses, primarily H5N1 and H7N9 subtypes, transmitted from infected birds to humans.
How it's Diagnosed: videos
PCR testing, viral culture, or antigen detection from respiratory specimens.
Treatment:
Antiviral medications like oseltamivir or zanamivir. Supportive care may include oxygen therapy or mechanical ventilation in severe cases.
Medications:
Oseltamivir (Tamiflu ) and zanamivir (Relenza ), which are neuraminidase inhibitors classified as antiviral agents.
Prevalence:
How common the health condition is within a specific population.
Sporadic; occurs in regions with close contact between humans and infected birds.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Contact with infected poultry, live bird markets, and poor biosecurity measures.
Prognosis:
The expected outcome or course of the condition over time.
High mortality rate, especially in H5N1 cases (about 60% case fatality rate). Early treatment improves outcomes.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Acute respiratory distress syndrome (ARDS), multi-organ failure, and death.
B Virus (Macacine Herpesvirus 1, Herpes B)
Specialty: Infectious Diseases
Category: Viral Infections
Symptoms:
fever; chills; muscle aches; lesions at the exposure site; neurological symptoms (headache, confusion, ataxia)
Root Cause:
A rare zoonotic infection transmitted from macaque monkeys, caused by herpesvirus simiae.
How it's Diagnosed: videos
PCR testing of lesion samples or cerebrospinal fluid, serological testing.
Treatment:
Antiviral therapy with acyclovir, valacyclovir, or ganciclovir; immediate wound cleaning is critical.
Medications:
Acyclovir , valacyclovir , and ganciclovir ; these are classified as antiviral agents targeting herpesviruses.
Prevalence:
How common the health condition is within a specific population.
Extremely rare; mostly reported in individuals handling macaques in research or zoos.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Monkey bites, scratches, or exposure to infected bodily fluids.
Prognosis:
The expected outcome or course of the condition over time.
Potentially fatal if untreated; timely antiviral therapy can be life-saving.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Encephalitis, permanent neurological damage, and death.
Bocavirus
Specialty: Infectious Diseases
Category: Viral Infections
Symptoms:
respiratory symptoms (cough, wheezing, runny nose); fever; gastrointestinal symptoms (diarrhea, vomiting); possible acute respiratory distress in severe cases
Root Cause:
Caused by human bocaviruses, part of the Parvoviridae family, typically infecting the respiratory and gastrointestinal tracts.
How it's Diagnosed: videos
PCR testing of respiratory secretions or stool samples; serological tests in research settings.
Treatment:
Supportive care, including hydration, antipyretics, and oxygen therapy if required.
Medications:
No specific antiviral medications; treatment is supportive.
Prevalence:
How common the health condition is within a specific population.
Common in children; responsible for 5-10% of respiratory infections in hospitalized pediatric patients.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Young age, immunosuppression, and pre-existing respiratory conditions.
Prognosis:
The expected outcome or course of the condition over time.
Good in healthy individuals; severe cases can occur in immunocompromised patients.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Pneumonia, bronchiolitis, and prolonged illness in immunocompromised hosts.
Bowenoid Papulosis
Specialty: Infectious Diseases
Category: Viral Infections
Symptoms:
reddish-brown or flesh-colored lesions on the genitals; asymptomatic or mild itching; sometimes tender lesions
Root Cause:
Caused by certain strains of human papillomavirus (HPV), particularly high-risk types like HPV-16, leading to changes in skin cells resembling carcinoma in situ.
How it's Diagnosed: videos
Diagnosed via clinical examination, dermoscopy, and confirmed with a biopsy showing histopathological features like koilocytosis and dysplasia.
Treatment:
Topical treatments (imiquimod or 5-fluorouracil), cryotherapy, laser ablation, or surgical excision; regular monitoring for malignancy.
Medications:
Topical imiquimod (an immune response modifier) or 5-fluorouracil (a topical chemotherapeutic agent) are commonly prescribed.
Prevalence:
How common the health condition is within a specific population.
Rare condition, more common in sexually active individuals with high-risk HPV exposure.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
HPV infection, unprotected sexual activity, multiple sexual partners, immunosuppression.
Prognosis:
The expected outcome or course of the condition over time.
Generally benign, but there is a risk of progression to squamous cell carcinoma if untreated.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Potential progression to invasive squamous cell carcinoma or persistent lesions despite treatment.
Smallpox
Specialty: Infectious Diseases
Category: COVID-19 Reinfections
Symptoms:
high fever; rash that progresses from spots to fluid-filled blisters; headache; backache; vomiting; fatigue
Root Cause:
Caused by the variola virus, leading to severe systemic infection with a characteristic skin rash.
How it's Diagnosed: videos
Clinical diagnosis based on the characteristic rash and fever pattern; PCR testing can confirm the variola virus.
Treatment:
No specific antiviral treatment. Smallpox was eradicated in 1980 through vaccination. Supportive care for those affected.
Medications:
Antiviral treatments like tecovirimat (TPOXX), classified as an antiviral medication, are used in some cases under emergency protocols.
Prevalence:
How common the health condition is within a specific population.
Smallpox was eradicated in 1980 and is no longer a public health threat.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Lack of vaccination, close contact with infected individuals.
Prognosis:
The expected outcome or course of the condition over time.
Smallpox has been eradicated, but untreated infections historically had a high mortality rate.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Secondary bacterial infections, blindness, scarring, death.
Viral Hemorrhagic Fevers (VHFs)
Specialty: Infectious Diseases
Category: Viral Infections
Symptoms:
fever; fatigue; muscle aches; bleeding from mucosal surfaces; hypotension; multi-organ failure
Root Cause:
Caused by a group of viruses (e.g., Ebola, Marburg, Lassa, Crimean-Congo hemorrhagic fever) leading to vascular instability and coagulopathy.
How it's Diagnosed: videos
Diagnosed via clinical history, serology (ELISA), PCR, and viral culture; biosafety precautions are critical during testing.
Treatment:
Supportive care (fluid replacement, oxygen therapy), antivirals like ribavirin for specific types (e.g., Lassa fever); experimental treatments may be used for others (e.g., monoclonal antibodies for Ebola).
Medications:
Ribavirin (antiviral for Lassa fever) and monoclonal antibodies like Inmazeb (antibodies for Ebola virus).
Prevalence:
How common the health condition is within a specific population.
Regional outbreaks in endemic areas; specific prevalence varies by virus and location.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Exposure to infected animals or humans, travel to endemic areas, healthcare work without adequate PPE.
Prognosis:
The expected outcome or course of the condition over time.
High mortality rates (up to 90% for some viruses like Ebola) without treatment; early supportive care improves outcomes.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Organ failure, shock, disseminated intravascular coagulation (DIC), long-term sequelae like fatigue or neurological symptoms.
Chickenpox (Varicella)
Specialty: Infectious Diseases
Category: Viral Infections
Symptoms:
fever; itchy rash that progresses from macules to papules to vesicles and crusts; fatigue; loss of appetite
Root Cause:
Caused by varicella-zoster virus (VZV), leading to a primary systemic infection.
How it's Diagnosed: videos
Clinically diagnosed based on the characteristic rash; PCR or serology may confirm uncertain cases.
Treatment:
Supportive care (antihistamines, acetaminophen for fever); antiviral medications like acyclovir for severe cases or immunocompromised patients.
Medications:
Acyclovir (antiviral inhibiting viral DNA synthesis), valacyclovir (prodrug of acyclovir ), and famciclovir (antiviral).
Prevalence:
How common the health condition is within a specific population.
Common worldwide before vaccination; significantly reduced in vaccinated populations.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Lack of vaccination, exposure to infected individuals, immunosuppression.
Prognosis:
The expected outcome or course of the condition over time.
Self-limited in healthy individuals; complications more likely in adults or immunocompromised patients.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Secondary bacterial infections, pneumonia, encephalitis, and, later in life, reactivation as shingles.
Chikungunya Virus Infection
Specialty: Infectious Diseases
Category: Viral Infections
Symptoms:
fever; severe joint pain; rash; headache; nausea
Root Cause:
Caused by Chikungunya virus, transmitted by Aedes mosquitoes, leading to systemic inflammation and viral replication.
How it's Diagnosed: videos
Diagnosed via PCR, serology (IgM/IgG antibodies), or viral culture.
Treatment:
Symptomatic treatment with NSAIDs, hydration, and rest; no specific antiviral available.
Medications:
NSAIDs like ibuprofen or acetaminophen for pain and fever.
Prevalence:
How common the health condition is within a specific population.
Endemic in tropical and subtropical regions; outbreaks reported globally due to travel and mosquito spread.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Living in or traveling to endemic areas, exposure to mosquito bites, lack of vector control measures.
Prognosis:
The expected outcome or course of the condition over time.
Generally self-limiting; joint pain may persist for months.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic arthritis, encephalitis, myocarditis, and rarely death in vulnerable populations.
COVID-19 Reinfections
Specialty: Infectious Diseases
Category: COVID-19 Reinfections
Symptoms:
fever; cough; shortness of breath; fatigue; loss of taste or smell; headaches; muscle aches
Root Cause:
Reinfections occur when an individual contracts SARS-CoV-2 again after recovery, potentially due to waning immunity or new variants evading immunity.
How it's Diagnosed: videos
Polymerase chain reaction (PCR) or antigen tests confirming a new infection, with prior documented infection and recovery. Whole-genome sequencing can differentiate reinfection from prolonged viral shedding.
Treatment:
Supportive care, antivirals (e.g., remdesivir), monoclonal antibodies, and symptomatic management depending on severity.
Medications:
Antivirals like remdesivir , nirmatrelvir /ritonavir (Paxlovid ), monoclonal antibodies (e.g., sotrovimab , bebtelovimab ).
Prevalence:
How common the health condition is within a specific population.
Becoming more common globally as new variants emerge; varies by region and vaccination status.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Waning immunity, lack of vaccination, exposure to highly transmissible variants, immunosuppression.
Prognosis:
The expected outcome or course of the condition over time.
Most reinfections are mild, especially in vaccinated individuals; severe outcomes are rare but possible in high-risk populations.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Severe respiratory disease, long COVID, organ dysfunction in severe cases.
COVID-19 Variants
Specialty: Infectious Diseases
Category: Emerging Infectious Diseases
Sub-category: Viral Evolution
Symptoms:
similar to standard covid-19 symptoms but may vary in severity or transmissibility; fever, cough, fatigue, loss of taste or smell, shortness of breath
Root Cause:
Variants arise through mutations in the SARS-CoV-2 genome, potentially increasing transmissibility, evasion of immunity, or altering disease severity.
How it's Diagnosed: videos
PCR and sequencing tests to identify specific variants; general symptoms are indistinguishable without genetic testing.
Treatment:
Same as for COVID-19; treatment tailored based on disease severity and resistance patterns of the variant.
Medications:
Similar to other COVID-19 treatments, including antivirals (remdesivir , molnupiravir ), monoclonal antibodies (variant-specific formulations), and steroids (dexamethasone ).
Prevalence:
How common the health condition is within a specific population.
Variant prevalence changes over time; major variants include Alpha, Delta, Omicron, and their subvariants.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Unvaccinated status, immune suppression, and high exposure in densely populated areas.
Prognosis:
The expected outcome or course of the condition over time.
Varies; mild for most variants but can cause severe disease in vulnerable populations. Vaccination typically mitigates severe outcomes.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Increased strain on healthcare systems, long COVID, and potential immune escape leading to reinfections.
Coxsackieviruses
Specialty: Infectious Diseases
Category: COVID-19 Reinfections
Symptoms:
fever; sore throat; rash; blisters on hands, feet, and inside the mouth; chest pain; fatigue
Root Cause:
Coxsackieviruses are part of the enterovirus family, causing infections that affect the skin, respiratory tract, and sometimes the heart or central nervous system.
How it's Diagnosed: videos
Clinical evaluation of symptoms, throat swabs, stool samples, or cerebrospinal fluid testing for viral culture or PCR.
Treatment:
Supportive care including hydration, antipyretics for fever, and pain relievers for sore throat and muscle aches.
Medications:
No specific antiviral therapy; symptomatic treatments include non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or acetaminophen for fever and pain.
Prevalence:
How common the health condition is within a specific population.
Common globally; most cases occur in children, particularly under 10 years old.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Young age, poor hygiene, crowded living conditions, and seasonal peaks in summer and fall.
Prognosis:
The expected outcome or course of the condition over time.
Generally good; most infections resolve without complications. Severe cases involving the heart or CNS are rare but may require hospitalization.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Myocarditis, aseptic meningitis, encephalitis, and hand-foot-and-mouth disease.
Cutaneous Manifestations of Hepatitis C
Specialty: Infectious Diseases
Category: Viral Hepatitis Complications
Sub-category: Dermatologic Disorders
Symptoms:
lichen planus; cryoglobulinemic vasculitis; porphyria cutanea tarda; necrotizing vasculitis; urticaria
Root Cause:
Immune-mediated responses or direct effects of chronic Hepatitis C virus (HCV) infection causing dermatologic manifestations.
How it's Diagnosed: videos
Hepatitis C serology (anti-HCV antibodies), HCV RNA PCR testing, skin biopsy for specific lesions.
Treatment:
Management of HCV with direct-acting antiviral agents (e.g., sofosbuvir, ledipasvir) combined with treatments specific to the dermatologic condition.
Medications:
Direct-acting antivirals (e.g., sofosbuvir —an HCV polymerase inhibitor; ribavirin —antiviral therapy). Dermatologic treatments include corticosteroids or immunosuppressants for inflammatory skin conditions.
Prevalence:
How common the health condition is within a specific population.
HCV affects approximately 1% of the global population; skin manifestations occur in 15–20% of those infected.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Chronic HCV infection, co-infection with other viruses, and poor immune response.
Prognosis:
The expected outcome or course of the condition over time.
Good with antiviral therapy; most dermatologic symptoms improve with successful HCV treatment.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Progressive liver disease, systemic vasculitis, and persistent skin conditions.
Cytomegalovirus (CMV)
Specialty: Infectious Diseases
Category: Viral Infections
Symptoms:
fever; fatigue; sore throat; swollen glands; jaundice; muscle aches
Root Cause:
CMV is a herpesvirus that establishes lifelong latent infection and can reactivate, especially in immunocompromised individuals.
How it's Diagnosed: videos
CMV DNA PCR, antigenemia assay, and tissue biopsy with characteristic histopathological findings.
Treatment:
Antiviral therapy for symptomatic or immunocompromised patients. Supportive care for mild cases.
Medications:
Ganciclovir and valganciclovir (antiviral agents). Foscarnet or cidofovir may be used for resistant cases.
Prevalence:
How common the health condition is within a specific population.
Approximately 50–80% of adults worldwide are seropositive for CMV.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Immunosuppression (e.g., organ transplantation, HIV), close contact with infected bodily fluids, congenital infection.
Prognosis:
The expected outcome or course of the condition over time.
Good for immunocompetent individuals; potentially severe in immunocompromised patients.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Congenital CMV, CMV retinitis, pneumonitis, hepatitis, and gastrointestinal ulcers.
Cytomegalovirus (CMV) Retinitis
Specialty: Infectious Diseases
Category: Viral Infections
Sub-category: Ophthalmologic Complications
Symptoms:
blurry vision; floaters; loss of peripheral vision; blind spots; progressive vision loss
Root Cause:
CMV infection of the retina, leading to retinal necrosis and scarring, primarily affecting immunocompromised individuals.
How it's Diagnosed: videos
Ophthalmologic examination (fundoscopy) revealing characteristic retinal changes, confirmed by CMV DNA PCR in blood or vitreous fluid.
Treatment:
Intravitreal antiviral injections and systemic antiviral therapy to control CMV.
Medications:
Ganciclovir (intravitreal or intravenous), valganciclovir (oral), foscarnet (intravenous for resistant cases).
Prevalence:
How common the health condition is within a specific population.
Common among patients with AIDS or other immunosuppressive conditions, particularly with CD4 counts below 50 cells/micro L.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Advanced HIV/AIDS, organ transplantation, immunosuppressive therapy.
Prognosis:
The expected outcome or course of the condition over time.
Poor without treatment; blindness can occur. With timely therapy, vision can be preserved in some cases.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Retinal detachment, blindness, and secondary infections.
Cytomegalovirus Organism-Specific Therapy
Specialty: Infectious Diseases
Category: Antiviral Treatment
Sub-category: Targeted Infections
Symptoms:
not applicable (focus is on treatment protocols).
Root Cause:
CMV causes significant morbidity in immunocompromised patients, necessitating targeted antiviral therapy.
How it's Diagnosed: videos
CMV DNA PCR, antigenemia assays, and culture methods to confirm active CMV infection.
Treatment:
Systemic antiviral drugs with specific regimens tailored to the severity and site of infection.
Medications:
Ganciclovir (DNA polymerase inhibitor), valganciclovir (oral prodrug of ganciclovir ), foscarnet (pyrophosphate analog), cidofovir (nucleotide analog).
Prevalence:
How common the health condition is within a specific population.
High among immunocompromised populations, such as transplant recipients and HIV-positive individuals.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Immunosuppression, congenital CMV, prolonged hospitalization.
Prognosis:
The expected outcome or course of the condition over time.
Effective therapy reduces morbidity and mortality in immunocompromised patients.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Drug resistance, nephrotoxicity, and recurrence of infection.
Dengue
Specialty: Infectious Diseases
Category: Arboviral Diseases
Sub-category: Hemorrhagic Fevers
Symptoms:
high fever; severe headache; retro-orbital pain; joint and muscle pain; rash; bleeding tendencies
Root Cause:
Dengue virus infection transmitted by Aedes mosquitoes, causing systemic inflammation and vascular permeability.
How it's Diagnosed: videos
Dengue NS1 antigen test, IgM/IgG serology, and RT-PCR for viral RNA.
Treatment:
Supportive care, fluid replacement, and monitoring for complications such as hemorrhagic fever or shock syndrome.
Medications:
No specific antiviral therapy; acetaminophen for fever. Avoid NSAIDs and aspirin due to bleeding risks.
Prevalence:
How common the health condition is within a specific population.
Endemic in over 100 countries, with 390 million infections annually worldwide.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Living in or traveling to endemic areas, prior dengue infection (risk for severe disease), and mosquito exposure.
Prognosis:
The expected outcome or course of the condition over time.
Good for most cases with timely supportive care; severe cases can be fatal without intervention.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Dengue hemorrhagic fever, dengue shock syndrome, organ failure.
Dermatologic Manifestations of Rubella
Specialty: Infectious Diseases
Category: Viral Exanthems
Sub-category: Dermatologic Disorders
Symptoms:
pink, maculopapular rash; fever; lymphadenopathy; joint pain; red spots on the soft palate (forchheimer spots)
Root Cause:
Rubella virus infection causing immune-mediated skin and systemic reactions.
How it's Diagnosed: videos
Clinical evaluation of rash and symptoms, confirmed by rubella IgM antibodies or PCR.
Treatment:
Supportive care, as the disease is usually self-limiting. Vaccination is key for prevention.
Medications:
No specific antiviral therapy; symptomatic relief includes acetaminophen or NSAIDs for fever and pain.
Prevalence:
How common the health condition is within a specific population.
Reduced globally due to vaccination; still occurs in regions with low immunization rates.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Lack of vaccination, pregnancy (risk of congenital rubella syndrome), and close contact with infected individuals.
Prognosis:
The expected outcome or course of the condition over time.
Good for most individuals; self-limiting in immunocompetent hosts.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Arthralgia, encephalitis, congenital rubella syndrome in pregnant women.
Dermatologic Manifestations of Viral Hemorrhagic Fevers
Specialty: Infectious Diseases
Category: COVID-19 Reinfections
Symptoms:
rash; petechiae; purpura; ecchymoses; erythema; skin necrosis
Root Cause:
Widespread endothelial damage caused by viral infection, leading to vascular leakage, coagulopathy, and immune-mediated skin changes.
How it's Diagnosed: videos
Clinical examination of skin lesions, history of potential exposure, serological tests, PCR for specific viruses, and coagulation studies.
Treatment:
Supportive care, management of coagulopathy, antiviral medications (if available for the specific virus), and wound care for necrotic skin lesions.
Medications:
Ribavirin (antiviral) for certain hemorrhagic fevers; immune modulators such as corticosteroids in severe inflammatory cases; broad-spectrum antibiotics to prevent secondary bacterial infections.
Prevalence:
How common the health condition is within a specific population.
Rare, associated with outbreaks of specific viral hemorrhagic fevers like Ebola, Dengue, and Lassa Fever.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Contact with infected individuals or animals, living in or traveling to endemic regions, poor infection control measures.
Prognosis:
The expected outcome or course of the condition over time.
Variable; dependent on the specific virus and timely access to medical care. Severe cases with extensive vascular damage have a higher mortality rate.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Disseminated intravascular coagulation (DIC), multiorgan failure, secondary infections, and permanent scarring.
Ebola Virus Infection
Specialty: Infectious Diseases
Category: Viral Hemorrhagic Fevers
Sub-category: Filoviruses
Symptoms:
fever; severe headache; muscle pain; fatigue; diarrhea; vomiting; abdominal pain; unexplained bleeding or bruising
Root Cause:
Systemic infection caused by the Ebola virus, leading to vascular damage, coagulopathy, and immune system dysregulation.
How it's Diagnosed: videos
PCR testing for Ebola RNA, enzyme-linked immunosorbent assay (ELISA), antigen detection tests, and clinical signs in endemic areas.
Treatment:
Supportive care including fluids, electrolyte management, oxygen therapy, and blood products; antivirals like Inmazeb (monoclonal antibody combination) may be used.
Medications:
Inmazeb (monoclonal antibody therapy), mAb114 (monoclonal antibody), and experimental antiviral drugs under trial during outbreaks.
Prevalence:
How common the health condition is within a specific population.
Outbreaks primarily in sub-Saharan Africa; rare outside endemic areas.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Contact with infected individuals, handling contaminated body fluids, exposure to bats or other reservoir species, and poor infection control practices.
Prognosis:
The expected outcome or course of the condition over time.
Mortality rates range from 25% to 90%, depending on the strain and access to medical care. Survivors often experience long-term complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Multiorgan failure, shock, disseminated intravascular coagulation (DIC), and long-term sequelae such as joint pain and vision problems.
Echovirus Infection
Specialty: Infectious Diseases
Category: Enteroviruses
Sub-category: Non-Polio Enteroviruses
Symptoms:
fever; rash; sore throat; gastrointestinal discomfort; meningitis (in severe cases); muscle aches; upper respiratory symptoms
Root Cause:
Viral infection affecting various tissues, leading to mild to severe systemic manifestations, often targeting the gastrointestinal or central nervous system.
How it's Diagnosed: videos
PCR testing of stool, throat swabs, cerebrospinal fluid (in meningitis cases), or blood samples; serology for antibody detection.
Treatment:
Symptomatic management, including fever reducers, hydration, and pain relievers; hospitalization in severe cases (e.g., aseptic meningitis).
Medications:
No specific antiviral medications; symptomatic treatments include acetaminophen or ibuprofen (antipyretics) and IV fluids for severe dehydration.
Prevalence:
How common the health condition is within a specific population.
Common worldwide; outbreaks can occur in daycare centers, schools, and crowded environments.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Young age (infants and children), poor hygiene, crowded living conditions.
Prognosis:
The expected outcome or course of the condition over time.
Most cases are self-limiting and resolve without complications; severe cases of meningitis or myocarditis may require prolonged care.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Aseptic meningitis, encephalitis, myocarditis, and neonatal sepsis-like illness in newborns.
Emergent Management of Pediatric Patients with Fever
Specialty: Infectious Diseases
Category: Pediatric Emergencies
Sub-category: Fever of Unknown Origin
Symptoms:
fever >38°c; irritability; lethargy; rash; vomiting; seizures (febrile); respiratory distress
Root Cause:
Fever in children may indicate an underlying infection, inflammatory condition, or other systemic issues requiring prompt evaluation.
How it's Diagnosed: videos
History and physical examination, blood tests (CBC, blood cultures), urinalysis, imaging studies (e.g., chest X-ray), lumbar puncture for meningitis suspicion.
Treatment:
Antipyretics, empiric antibiotics if bacterial infection is suspected, IV fluids for dehydration, and treatment of specific underlying conditions.
Medications:
Acetaminophen or ibuprofen for fever; empiric antibiotics such as ceftriaxone or ampicillin in suspected sepsis or meningitis; antiviral agents like acyclovir for herpes encephalitis .
Prevalence:
How common the health condition is within a specific population.
Fever is one of the most common presentations in pediatric emergencies worldwide.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Young age, incomplete vaccination status, recent illness or infection, and exposure to sick individuals.
Prognosis:
The expected outcome or course of the condition over time.
Good in most cases with timely diagnosis and treatment; prognosis depends on the underlying cause of the fever.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Febrile seizures, dehydration, sepsis, and delay in diagnosing life-threatening conditions.
Enterovirus D68
Specialty: Infectious Diseases
Category: Respiratory Viruses
Sub-category: Enteroviruses
Symptoms:
fever; cough; wheezing; shortness of breath; runny nose; muscle aches; acute flaccid myelitis (rare)
Root Cause:
Respiratory and occasionally neurological illness caused by Enterovirus D68, leading to inflammation in the respiratory tract or nervous system.
How it's Diagnosed: videos
PCR testing of nasopharyngeal swabs or throat samples; clinical correlation with respiratory symptoms and neurological signs in rare cases.
Treatment:
Supportive care, including oxygen therapy for respiratory distress; mechanical ventilation in severe cases.
Medications:
No specific antiviral medications; supportive care includes bronchodilators for wheezing and corticosteroids for severe inflammation.
Prevalence:
How common the health condition is within a specific population.
Seasonal outbreaks, particularly in children, with periodic spikes globally.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Young age, asthma, or other chronic respiratory conditions; exposure to infected individuals in schools or daycare centers.
Prognosis:
The expected outcome or course of the condition over time.
Most cases resolve with supportive care; rare cases of acute flaccid myelitis may lead to long-term disability.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Acute flaccid myelitis (AFM), respiratory failure, and secondary infections.
Enteroviruses
Specialty: Infectious Diseases
Category: Non-Polio Enteroviruses
Sub-category: General Infections
Symptoms:
fever; rash; sore throat; gastroenteritis; viral meningitis; conjunctivitis; myalgia
Root Cause:
Widespread viral infections affecting the gastrointestinal, respiratory, or central nervous systems depending on the strain.
How it's Diagnosed: videos
PCR testing of stool, cerebrospinal fluid, or throat swabs; serological tests for specific antibodies.
Treatment:
Symptomatic care, including hydration, antipyretics, and analgesics; severe cases may require hospitalization for meningitis or myocarditis.
Medications:
Supportive treatments such as acetaminophen or ibuprofen for fever and pain; no specific antivirals available for most strains.
Prevalence:
How common the health condition is within a specific population.
Highly prevalent worldwide, particularly in children and during summer-fall seasons.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Young age, crowded living conditions, exposure to contaminated water or surfaces.
Prognosis:
The expected outcome or course of the condition over time.
Generally good, with most infections resolving spontaneously; complications may occur in immunocompromised individuals.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Viral meningitis, encephalitis, myocarditis, and neonatal infections.
Epidermodysplasia Verruciformis
Specialty: Infectious Diseases
Category: COVID-19 Reinfections
Symptoms:
flat, wart-like lesions on the skin; scaly macules or papules; lesions on sun-exposed areas; pruritus or irritation in affected regions
Root Cause:
A genetic mutation affecting EVER1 or EVER2 genes, leading to susceptibility to infection by human papillomaviruses (HPVs).
How it's Diagnosed: videos
Clinical examination of skin lesions, biopsy for histopathological analysis, and genetic testing to confirm mutations in associated genes.
Treatment:
Topical or systemic retinoids, surgical removal of lesions, cryotherapy, and strict sun protection.
Medications:
Retinoids (e.g., Acitretin , a keratolytic agent), topical imiquimod (immune response modifier). Antivirals and immunotherapy are sometimes used experimentally.
Prevalence:
How common the health condition is within a specific population.
Extremely rare, with fewer than 500 cases reported globally.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Autosomal recessive inheritance; exposure to high-risk HPV strains; immunosuppression.
Prognosis:
The expected outcome or course of the condition over time.
Lifelong management is required. Early treatment can reduce complications, but there is a risk of malignant transformation to squamous cell carcinoma.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Development of skin cancers, particularly squamous cell carcinoma, in affected areas.
Epstein-Barr Virus (EBV) Infectious Mononucleosis
Specialty: Infectious Diseases
Category: Viral Infections
Symptoms:
fatigue; fever; sore throat; swollen lymph nodes; splenomegaly; rash
Root Cause:
EBV infection targets B lymphocytes, causing an immune response that leads to widespread inflammation and systemic symptoms.
How it's Diagnosed: videos
Monospot test, EBV serology (antibody testing), complete blood count (CBC) with atypical lymphocytosis.
Treatment:
Supportive care (hydration, rest, antipyretics). Corticosteroids in severe cases of airway obstruction.
Medications:
No specific antiviral therapy; symptomatic treatment includes NSAIDs like ibuprofen or acetaminophen for fever and sore throat.
Prevalence:
How common the health condition is within a specific population.
Affects 90–95% of the global population at some point in life; symptomatic mono occurs primarily in adolescents and young adults.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Close contact with infected individuals, immunosuppression, and young age (15–25 years).
Prognosis:
The expected outcome or course of the condition over time.
Excellent in most cases, with symptoms resolving within 2–4 weeks; fatigue may persist longer.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Splenic rupture, secondary bacterial infections, autoimmune hemolytic anemia, and rarely, lymphoma.
Erythema Infectiosum
Specialty: Infectious Diseases
Category: Viral Infections
Sub-category: Childhood Exanthems
Symptoms:
slapped-cheek facial rash; low-grade fever; joint pain or swelling; fatigue; lace-like rash on the body
Root Cause:
Parvovirus B19 infects red blood cell precursors, causing transient aplastic crises in certain individuals.
How it's Diagnosed: videos
Clinical presentation, parvovirus B19 IgM and IgG antibody testing, and PCR for viral DNA.
Treatment:
Supportive care, including antipyretics and hydration; blood transfusion in severe anemia.
Medications:
NSAIDs (e.g., ibuprofen for joint symptoms). Immunoglobulin therapy in immunocompromised individuals.
Prevalence:
How common the health condition is within a specific population.
Common in children, with outbreaks in schools; seroprevalence increases with age.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Close contact with infected individuals, underlying hemolytic disorders, or pregnancy.
Prognosis:
The expected outcome or course of the condition over time.
Self-limiting in most cases; excellent prognosis.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Fetal hydrops in pregnant women, chronic anemia in immunocompromised individuals.
Giant Condylomata Acuminata of Buschke and Lowenstein
Specialty: Infectious Diseases
Category: HPV-Associated Conditions
Sub-category: Genital Lesions
Symptoms:
large, cauliflower-like genital growths; malodor; pain; ulceration or secondary infections
Root Cause:
Chronic infection with low-risk and high-risk HPV strains, leading to unchecked hyperplasia of genital epithelium.
How it's Diagnosed: videos
Clinical examination, biopsy to rule out malignancy, HPV typing.
Treatment:
Surgical excision, CO2 laser therapy, and topical treatments like imiquimod.
Medications:
Topical imiquimod (immune response modifier), podophyllotoxin (antimitotic agent).
Prevalence:
How common the health condition is within a specific population.
Rare but seen in immunocompromised populations.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Immunosuppression, high-risk sexual behavior, lack of HPV vaccination.
Prognosis:
The expected outcome or course of the condition over time.
Guarded due to the risk of recurrence and malignant transformation to squamous cell carcinoma.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Secondary infections, malignancy, and physical discomfort.
H1N1 Influenza (Swine Flu)
Specialty: Infectious Diseases
Category: Respiratory Infections
Sub-category: Seasonal Influenza Variants
Symptoms:
fever; cough; sore throat; runny or stuffy nose; myalgia; fatigue; chills; headache
Root Cause:
A strain of influenza A virus that causes respiratory infection with potential for severe pulmonary complications.
How it's Diagnosed: videos
Rapid influenza diagnostic tests (RIDTs), PCR for influenza RNA, clinical presentation during outbreak seasons.
Treatment:
Antiviral therapy (e.g., oseltamivir or zanamivir), supportive care (hydration, rest, antipyretics).
Medications:
Oseltamivir (neuraminidase inhibitor), zanamivir (neuraminidase inhibitor), antipyretics like acetaminophen or ibuprofen .
Prevalence:
How common the health condition is within a specific population.
Responsible for the 2009 pandemic; seasonal outbreaks continue.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Young children, elderly individuals, pregnant women, and those with chronic medical conditions.
Prognosis:
The expected outcome or course of the condition over time.
Excellent in mild cases with timely treatment; severe cases can result in hospitalization or death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Pneumonia, acute respiratory distress syndrome (ARDS), secondary bacterial infections, and multi-organ failure in severe cases.
Herpes Simplex
Specialty: Infectious Diseases
Category: Viral Infections
Symptoms:
painful blisters or sores around the mouth or genitals; itching or tingling sensations; fever; swollen lymph nodes; pain during urination (genital hsv)
Root Cause:
Caused by the Herpes Simplex Virus (HSV), primarily HSV-1 (oral herpes) and HSV-2 (genital herpes). The virus infects nerve cells and establishes latency, reactivating under certain conditions.
How it's Diagnosed: videos
Diagnosis is through clinical examination, polymerase chain reaction (PCR) testing, viral culture, or serology for HSV antibodies.
Treatment:
Antiviral therapy to reduce symptoms and frequency of outbreaks; suppressive therapy for recurrent cases.
Medications:
Antiviral medications such as acyclovir (a nucleoside analog), valacyclovir (a prodrug of acyclovir ), and famciclovir (a guanosine analog). These drugs reduce viral replication and alleviate symptoms.
Prevalence:
How common the health condition is within a specific population.
Approximately two-thirds of the global population under 50 years old have HSV-1, and 11% have HSV-2.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Unprotected sexual contact, sharing personal items (e.g., razors, towels), weakened immune systems, and contact with infected individuals.
Prognosis:
The expected outcome or course of the condition over time.
Lifelong infection with periodic outbreaks; symptoms can be managed with treatment, and suppressive therapy can reduce recurrence and transmission risk.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Severe infections in immunocompromised individuals, neonatal herpes, herpetic keratitis (eye infection), and increased risk of HIV transmission.
Herpes Simplex Virus (HSV) Empiric Therapy
Specialty: Infectious Diseases
Category: Viral Infections
Sub-category: Therapeutic Approaches
Symptoms:
tingling or itching in areas of potential outbreak; blister formation; pain in affected areas; flu-like symptoms in primary infection
Root Cause:
Rapid initiation of therapy during suspected HSV reactivation is crucial to mitigate outbreak severity and duration.
How it's Diagnosed: videos
Empirical treatment based on patient-reported symptoms and history of outbreaks; confirmed with PCR or serology in uncertain cases.
Treatment:
Early initiation of antiviral therapy upon symptom onset or as suppressive treatment in recurrent cases.
Medications:
Acyclovir , valacyclovir , and famciclovir are commonly prescribed. All are antivirals that inhibit viral DNA polymerase activity.
Prevalence:
How common the health condition is within a specific population.
HSV is widespread; empiric therapy targets individuals with recurrent symptoms or known exposure.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Recurrent HSV infections, immunosuppression, and frequent triggers like stress or illness.
Prognosis:
The expected outcome or course of the condition over time.
Improves with timely treatment; reduces symptom duration and recurrence frequency.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Delayed treatment may lead to more severe outbreaks or complications like herpetic neuralgia.
Herpes Simplex Virus (HSV) Keratitis
Specialty: Infectious Diseases
Category: Viral Infections
Sub-category: Ocular Infections
Symptoms:
eye pain; redness; blurred vision; sensitivity to light; tearing; eye discharge; foreign body sensation in the eye
Root Cause:
HSV infection of the cornea, leading to inflammation and potential damage to the eye's surface. The virus can remain dormant in the trigeminal ganglion and reactivate, affecting the eye.
How it's Diagnosed: videos
Diagnosed through clinical examination, fluorescein staining, slit-lamp examination, PCR testing, and viral cultures.
Treatment:
Antiviral treatment, either topical or systemic, along with corticosteroids (in some cases) to control inflammation.
Medications:
Topical acyclovir (an antiviral), oral valacyclovir , and famciclovir (oral antivirals), often in combination with corticosteroids like prednisolone to reduce inflammation.
Prevalence:
How common the health condition is within a specific population.
HSV keratitis is the leading cause of infectious blindness in the developed world.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Previous ocular HSV infection, immunocompromised status, and trauma to the eye.
Prognosis:
The expected outcome or course of the condition over time.
With early treatment, the prognosis is generally good, but repeated infections can lead to scarring and vision loss.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Corneal scarring, glaucoma, and, in severe cases, permanent vision loss if untreated.
Human Cowpox Infection
Specialty: Infectious Diseases
Category: Viral Infections
Sub-category: Zoonotic Infections
Symptoms:
skin lesions; fever; headache; muscle aches; fatigue; swollen lymph nodes; blistering rash
Root Cause:
Infection with the cowpox virus, a zoonotic poxvirus primarily transmitted from animals (particularly rodents or cats) to humans through direct contact.
How it's Diagnosed: videos
Diagnosis is based on clinical presentation and confirmed with PCR or viral culture of the lesion.
Treatment:
Symptomatic treatment; in severe cases, antiviral drugs like tecovirimat (a smallpox drug) may be used.
Medications:
Tecovirimat (a drug used to treat orthopoxvirus infections like smallpox and cowpox) and cidofovir (an antiviral). Supportive care may include analgesics and wound care.
Prevalence:
How common the health condition is within a specific population.
Rare, with most cases occurring in people with direct contact with infected animals.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Animal exposure, particularly handling infected rodents or pets with cowpox lesions.
Prognosis:
The expected outcome or course of the condition over time.
Generally self-limiting, with most people recovering fully; however, complications can arise if untreated.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Secondary bacterial infections, scarring, or prolonged skin lesions in immunocompromised individuals.
Human Herpesvirus 6 (HHV-6) Infection
Specialty: Infectious Diseases
Category: Viral Infections
Sub-category: Herpesviridae Infections
Symptoms:
fever; rash (roseola); irritability; diarrhea; swollen lymph nodes; febrile seizures
Root Cause:
HHV-6 infection is caused by a virus that commonly infects infants and young children. It can cause roseola, a rash after fever, and may also be linked to certain neurological and autoimmune disorders.
How it's Diagnosed: videos
Diagnosis is typically based on clinical presentation, supported by PCR testing for viral DNA.
Treatment:
Symptomatic treatment for fever and seizures; antiviral medications may be used in severe cases.
Medications:
Ganciclovir and valganciclovir are antiviral medications that may be used for severe HHV-6 infections, especially in immunocompromised patients.
Prevalence:
How common the health condition is within a specific population.
Almost all individuals are infected with HHV-6 by the age of 2; it causes roseola in infants and can persist as a latent infection.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Age (infants are most affected), immunocompromised states (such as organ transplants or HIV/AIDS).
Prognosis:
The expected outcome or course of the condition over time.
Generally good in healthy children; complications arise in immunocompromised individuals.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Febrile seizures, encephalitis, and autoimmune diseases in rare cases.
Human Papillomavirus (HPV)
Specialty: Infectious Diseases
Category: Viral Infections
Sub-category: Oncogenic Infections
Symptoms:
genital warts; itching or discomfort in genital area; abnormal pap smear; throat or mouth lesions in oral hpv
Root Cause:
HPV is a group of viruses, some of which are oncogenic and can lead to cancers such as cervical, anal, and oropharyngeal cancers. HPV is transmitted through direct skin-to-skin or sexual contact.
How it's Diagnosed: videos
Diagnosis is made through physical examination, biopsy of suspicious lesions, and Pap smears for cervical HPV. HPV typing can be done through PCR or hybrid capture tests.
Treatment:
Warts can be treated with cryotherapy, laser therapy, or topical treatments; however, no cure exists for the virus itself.
Medications:
Topical imiquimod (an immune response modifier), podophyllin (a plant-derived compound ), or sinecatechins for genital warts.
Prevalence:
How common the health condition is within a specific population.
Over 80% of sexually active individuals are infected with HPV at some point in their lives.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Unprotected sexual activity, multiple sexual partners, immunocompromised conditions, and smoking.
Prognosis:
The expected outcome or course of the condition over time.
Many HPV infections clear spontaneously within 1-2 years; however, persistent infection with high-risk strains can lead to cancer.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Cervical cancer, anal cancer, and oropharyngeal cancer, as well as the potential for genital warts.
Human Papillomavirus (HPV) Organism-Specific Therapy
Specialty: Infectious Diseases
Category: COVID-19 Reinfections
Symptoms:
genital warts; throat warts; cervical dysplasia; oral lesions; abnormal pap smear results
Root Cause:
HPV is a viral infection that can cause abnormal cell growth, leading to warts and various cancers, especially cervical cancer.
How it's Diagnosed: videos
Diagnosed through physical exams (for warts), Pap tests (for cervical abnormalities), or DNA testing (for high-risk strains).
Treatment:
Treatment focuses on removing warts and abnormal tissue, though there's no cure for the virus itself. Options include cryotherapy, electrocautery, laser treatment, and surgical removal. Vaccination with the HPV vaccine can prevent certain strains.
Medications:
There are no antiviral medications specifically for HPV, but treatments for symptoms may include topical agents like imiquimod (an immune response modifier), podophyllin (a cytotoxic agent), or interferon .
Prevalence:
How common the health condition is within a specific population.
HPV is the most common sexually transmitted infection globally, affecting approximately 79 million Americans. Around 80% of sexually active individuals will acquire it at some point.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Unprotected sexual activity, multiple sexual partners, weakened immune system, smoking, and long-term use of oral contraceptives.
Prognosis:
The expected outcome or course of the condition over time.
Most HPV infections are cleared by the immune system without causing any health problems, but persistent infections can lead to cancers, particularly cervical cancer.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Long-term infections may lead to cancers (e.g., cervical, anal, throat) and persistent genital warts.
Human Parainfluenza Viruses (HPIV) and Other Parainfluenza Viruses
Specialty: Infectious Diseases
Category: COVID-19 Reinfections
Symptoms:
fever; cough; runny nose; wheezing; difficulty breathing; sore throat
Root Cause:
HPIVs cause respiratory infections, primarily affecting the upper and lower respiratory tracts. They can cause croup, bronchiolitis, and pneumonia.
How it's Diagnosed: videos
Diagnosis is based on clinical symptoms, and confirmation can be made through PCR tests, viral cultures, or rapid antigen tests.
Treatment:
Treatment is symptomatic, including hydration, fever management, and respiratory support. In severe cases, supplemental oxygen or mechanical ventilation may be necessary.
Medications:
Antiviral drugs are not typically used. Supportive medications, such as bronchodilators (e.g., albuterol ) or corticosteroids (e.g., prednisone ) for inflammation, may be prescribed.
Prevalence:
How common the health condition is within a specific population.
HPIV is common, particularly in children under 5, and outbreaks occur annually, typically in the fall and winter months.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Young age (especially infants), weakened immune system, and preexisting respiratory conditions.
Prognosis:
The expected outcome or course of the condition over time.
Most individuals recover without long-term complications, but the elderly and immunocompromised individuals may experience more severe disease.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Can lead to pneumonia, respiratory distress, and other severe respiratory issues in vulnerable populations.
Human T-Cell Lymphotropic Viruses (HTLV)
Specialty: Infectious Diseases
Category: COVID-19 Reinfections
Symptoms:
fatigue; muscle weakness; nerve pain; paralysis; abnormal skin rashes
Root Cause:
HTLV is a retrovirus that can lead to T-cell proliferation, causing disorders such as adult T-cell leukemia/lymphoma (ATLL) or HTLV-associated myelopathy (HAM).
How it's Diagnosed: videos
Diagnosed through blood tests to detect HTLV antibodies or PCR testing for the virus itself.
Treatment:
There is no cure for HTLV infections, but treatment for associated conditions like ATLL or HAM includes chemotherapy, antiretroviral therapy, and corticosteroids for symptom management.
Medications:
Antiretroviral therapy (e.g., zidovudine ) is sometimes used to control viral replication. Chemotherapy agents (e.g., cyclophosphamide ) are used for cancerous manifestations like ATLL.
Prevalence:
How common the health condition is within a specific population.
HTLV is less common globally, but it is prevalent in regions like Japan, the Caribbean, and parts of Africa.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Blood transfusions, sexual contact, and mother-to-child transmission are the main routes of HTLV transmission.
Prognosis:
The expected outcome or course of the condition over time.
The prognosis depends on the presence of associated conditions like ATLL or HAM, which can be severe or fatal if not treated.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
HTLV-associated diseases can lead to neurological disabilities, cancer, and premature death.
Kaposi Varicelliform Eruption
Specialty: Infectious Diseases
Category: COVID-19 Reinfections
Symptoms:
widespread vesicular rash; fever; malaise; lymphadenopathy; painful skin lesions
Root Cause:
Reactivation of herpesviruses or primary infection of eczematous skin caused by Herpes Simplex Virus (HSV), Varicella-Zoster Virus (VZV), or other viral agents. Often occurs in individuals with compromised skin barriers such as eczema.
How it's Diagnosed: videos
Clinical examination, Tzanck smear showing multinucleated giant cells, PCR for viral DNA, and skin biopsy if necessary.
Treatment:
Antiviral therapy, wound care, and management of any secondary infections.
Medications:
Acyclovir or valacyclovir (antiviral agents) are commonly prescribed to treat the underlying viral infection. Topical or systemic antibiotics may be used for secondary bacterial infections.
Prevalence:
How common the health condition is within a specific population.
Rare, primarily affects individuals with underlying skin conditions (e.g., eczema) or immunocompromised patients.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Eczema, immunosuppression, prior history of herpesvirus infection, contact with infected individuals.
Prognosis:
The expected outcome or course of the condition over time.
Generally favorable with prompt antiviral treatment; delays in treatment can lead to severe complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Bacterial superinfection, septicemia, and in rare cases, dissemination to internal organs in immunocompromised individuals.
Kuru
Specialty: Infectious Diseases
Category: COVID-19 Reinfections
Symptoms:
ataxia; tremors; muscle stiffness; emotional lability; dementia-like symptoms; difficulty swallowing
Root Cause:
Prion disease caused by the transmission of misfolded prion proteins through cannibalistic practices.
How it's Diagnosed: videos
Clinical presentation, genetic testing for prion protein gene mutations, and post-mortem brain biopsy showing spongiform degeneration.
Treatment:
No cure; supportive care focuses on managing symptoms and providing comfort.
Medications:
None; experimental treatments have been attempted but remain ineffective.
Prevalence:
How common the health condition is within a specific population.
Extremely rare; primarily observed in the Fore tribe of Papua New Guinea, where the disease originated.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Participation in cannibalistic rituals, exposure to infected neural tissue.
Prognosis:
The expected outcome or course of the condition over time.
Fatal; typically leads to death within 1–2 years of symptom onset.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Progressive neurological decline, complete loss of motor and cognitive functions, death.
Long Coronavirus 2019 (COVID-19)
Specialty: Infectious Diseases
Category: COVID-19 Reinfections
Symptoms:
fatigue; brain fog; persistent cough; shortness of breath; joint pain; chest pain; anxiety or depression
Root Cause:
Persistent inflammation and immune dysregulation following acute COVID-19 infection.
How it's Diagnosed: videos
Symptom persistence for >12 weeks post-infection; exclusion of other conditions; specialized post-COVID clinics.
Treatment:
Symptom management with physical therapy, mental health support, pulmonary rehabilitation, and medications tailored to specific symptoms.
Medications:
Antidepressants (SSRIs for anxiety or depression), bronchodilators (for respiratory symptoms), or antihistamines (for fatigue or brain fog).
Prevalence:
How common the health condition is within a specific population.
Estimated in 10–30% of individuals recovering from acute COVID-19.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Severe acute COVID-19, female sex, pre-existing comorbidities, unvaccinated status.
Prognosis:
The expected outcome or course of the condition over time.
Variable; symptoms may persist for months or resolve gradually.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic fatigue syndrome, pulmonary fibrosis, cardiovascular issues, mental health disorders.
Lymphocytic Choriomeningitis Virus (LCMV) Infection
Specialty: Infectious Diseases
Category: COVID-19 Reinfections
Symptoms:
fever; malaise; headache; nausea; vomiting; stiff neck; photophobia; confusion
Root Cause:
Infection caused by the LCMV, a rodent-borne arenavirus, leading to aseptic meningitis or meningoencephalitis in severe cases.
How it's Diagnosed: videos
Detection of LCMV-specific antibodies in cerebrospinal fluid (CSF) or blood, PCR for viral RNA, and history of exposure to rodents.
Treatment:
Supportive care, including pain management, anti-inflammatory medications, and fluid therapy; antivirals like ribavirin may be used experimentally.
Medications:
No FDA-approved specific treatment; ribavirin (antiviral) is sometimes used off-label for severe cases.
Prevalence:
How common the health condition is within a specific population.
Rare; exposure often occurs via infected rodents or their excreta, with occasional outbreaks in specific regions.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Exposure to rodents, handling pet hamsters, and living in environments with poor rodent control.
Prognosis:
The expected outcome or course of the condition over time.
Generally good with supportive care; severe cases can result in neurological complications or, rarely, death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Neurological deficits, hydrocephalus, hearing loss, and miscarriage during pregnancy.
Monkeypox (Mpox)
Specialty: Infectious Diseases
Category: COVID-19 Reinfections
Symptoms:
fever; headache; lymphadenopathy; rash progressing from macules to pustules; fatigue; muscle aches
Root Cause:
Zoonotic viral infection caused by the monkeypox virus, closely related to the smallpox virus.
How it's Diagnosed: videos
PCR for monkeypox DNA from lesion samples, electron microscopy, or viral culture.
Treatment:
Supportive care, antivirals such as tecovirimat, and prevention of secondary infections.
Medications:
Tecovirimat (antiviral) is FDA-approved for treatment. Cidofovir and brincidofovir are alternatives in severe cases.
Prevalence:
How common the health condition is within a specific population.
Endemic in parts of Central and West Africa; sporadic outbreaks reported globally.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Contact with infected animals, human-to-human transmission via respiratory droplets or skin lesions, and immunosuppression.
Prognosis:
The expected outcome or course of the condition over time.
Favorable in most cases; higher risk of severe outcomes in immunocompromised individuals or young children.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Secondary bacterial infections, pneumonia, encephalitis, and corneal infection leading to vision loss.
Norovirus
Specialty: Infectious Diseases
Category: COVID-19 Reinfections
Symptoms:
nausea; vomiting; diarrhea; abdominal cramps; fever; body aches; dehydration (in severe cases)
Root Cause:
Norovirus infection occurs when the virus infects the gastrointestinal tract, causing acute inflammation of the stomach and intestines. It is highly contagious and primarily spreads through contaminated food, water, surfaces, or direct contact.
How it's Diagnosed: videos
Diagnosis is usually clinical, based on symptoms and outbreak context. Laboratory testing (RT-PCR or enzyme immunoassay) can confirm norovirus presence in stool samples.
Treatment:
No specific antiviral treatment is available. Management focuses on supportive care, such as rehydration therapy (oral or IV) to replace lost fluids and electrolytes.
Medications:
There are no medications specifically targeting norovirus. Anti-nausea drugs like ondansetron (a serotonin 5-HT3 receptor antagonist) may be prescribed for severe vomiting. Oral rehydration salts (ORS) or electrolyte solutions help prevent dehydration.
Prevalence:
How common the health condition is within a specific population.
Norovirus causes approximately 685 million cases worldwide annually, with a significant impact on children under five years and older adults.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Close contact with infected individuals, consuming contaminated food or water, living in crowded environments (e.g., nursing homes, cruise ships), poor hand hygiene.
Prognosis:
The expected outcome or course of the condition over time.
Generally self-limiting; symptoms resolve within 1-3 days. Proper hydration ensures full recovery in most cases.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Severe dehydration, especially in young children, older adults, and immunocompromised individuals; rare cases of persistent gastrointestinal symptoms in vulnerable populations.
Orbivirus
Specialty: Infectious Diseases
Category: COVID-19 Reinfections
Symptoms:
fever; headache; muscle pain; rash; swelling around eyes and mouth (in severe cases); neurological symptoms (rare)
Root Cause:
Orbivirus infections are caused by double-stranded RNA viruses in the Reoviridae family. The virus is transmitted by arthropod vectors like midges, mosquitoes, or ticks, affecting humans, livestock, and wildlife. It leads to systemic inflammation and vascular damage.
How it's Diagnosed: videos
Diagnosis involves PCR or ELISA testing to detect viral RNA or antibodies in blood samples. Clinical symptoms and recent exposure to vectors are also considered.
Treatment:
No specific antiviral treatment is available. Supportive care includes managing fever and pain with analgesics and antipyretics, along with fluid replacement if necessary.
Medications:
There are no targeted medications for Orbivirus. Acetaminophen (paracetamol) may be used for fever and pain. In severe cases, corticosteroids like dexamethasone (an anti-inflammatory) may be administered to manage systemic inflammation.
Prevalence:
How common the health condition is within a specific population.
Found worldwide, but prevalence varies by region. Orbivirus-related diseases, like bluetongue in animals, are common in tropical and subtropical areas.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Exposure to arthropod vectors, living in or traveling to endemic regions, outdoor activities, weakened immune system.
Prognosis:
The expected outcome or course of the condition over time.
Most cases resolve without complications, but severe cases (e.g., those involving neurological symptoms) may require hospitalization.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Neurological damage, secondary infections, and systemic inflammation leading to organ damage in severe cases.
Parapoxviruses
Specialty: Infectious Diseases
Category: COVID-19 Reinfections
Symptoms:
skin lesions (red nodules, pustules); mild fever; fatigue; regional lymphadenopathy
Root Cause:
Parapoxvirus infections are caused by viruses in the Poxviridae family, transmitted through contact with infected animals (e.g., sheep, goats, cattle). The virus enters through breaks in the skin, leading to localized cutaneous infections.
How it's Diagnosed: videos
Diagnosis is typically clinical based on characteristic skin lesions and history of animal contact. Laboratory confirmation involves PCR or electron microscopy of lesion samples.
Treatment:
Treatment is supportive and includes wound care and analgesics for pain. Secondary bacterial infections may require antibiotics.
Medications:
No specific antiviral medication is available . Topical antiseptics or antibiotic creams (e.g., mupirocin ) are used for secondary infections. Acetaminophen or ibuprofen may help reduce pain and fever.
Prevalence:
How common the health condition is within a specific population.
Parapoxviruses are globally distributed, particularly in agricultural regions with high exposure to livestock. Zoonotic cases are sporadic.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Occupational exposure to infected animals, handling contaminated animal products, pre-existing skin injuries.
Prognosis:
The expected outcome or course of the condition over time.
Most infections are self-limiting and resolve within a few weeks without long-term effects.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Secondary bacterial infections of skin lesions, rarely systemic spread in immunocompromised individuals.
Pediatric Rubella
Specialty: Infectious Diseases
Category: COVID-19 Reinfections
Symptoms:
low-grade fever; rash (starting on the face and spreading downward); swollen lymph nodes (especially behind the ears); mild conjunctivitis; joint pain (in older children); cold-like symptoms (runny nose, sore throat)
Root Cause:
Rubella is caused by the Rubella virus, an RNA virus of the Togaviridae family. It spreads through respiratory droplets and primarily affects children who are not vaccinated. The virus replicates in the respiratory tract and lymphoid tissues, leading to systemic symptoms.
How it's Diagnosed: videos
Diagnosis is based on clinical symptoms and confirmed with serological testing (rubella IgM antibodies) or PCR to detect viral RNA.
Treatment:
No specific antiviral treatment is available. Supportive care includes managing fever and other symptoms with antipyretics and rest. Vaccination prevents the disease.
Medications:
Medications are primarily symptomatic
Prevalence:
How common the health condition is within a specific population.
Rare in regions with high vaccination coverage but still occurs in areas with low immunization rates.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Lack of vaccination, exposure to infected individuals, travel to regions with endemic rubella.
Prognosis:
The expected outcome or course of the condition over time.
In children, rubella is generally mild and self-limiting, with full recovery within one to two weeks.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Rare but include encephalitis, thrombocytopenia, and arthritis. If contracted during pregnancy, it can lead to congenital rubella syndrome, causing severe birth defects.
Pharyngoconjunctival Fever (PCF)
Specialty: Infectious Diseases
Category: COVID-19 Reinfections
Symptoms:
sore throat; conjunctivitis (pink eye); fever; headache; cough; runny nose; mild swelling of lymph nodes
Root Cause:
Inflammation of the pharynx and conjunctiva caused by an adenovirus infection, often affecting children and adolescents.
How it's Diagnosed: videos
Diagnosis is primarily clinical based on symptoms; laboratory tests, such as PCR (Polymerase Chain Reaction) or viral culture, can confirm adenovirus infection.
Treatment:
Treatment is symptomatic and supportive. This includes hydration, rest, and the use of over-the-counter pain relievers (e.g., acetaminophen or ibuprofen) for fever and discomfort.
Medications:
There are no specific antiviral medications for PCF, but over-the-counter medications like acetaminophen or ibuprofen may be used to manage symptoms. These medications are classified as antipyretics and analgesics.
Prevalence:
How common the health condition is within a specific population.
PCF is common, particularly in school-aged children and during outbreaks. It occurs worldwide.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Close contact with infected individuals, crowded environments like schools and daycare centers, and weakened immune systems increase susceptibility.
Prognosis:
The expected outcome or course of the condition over time.
The condition is typically self-limited and resolves within 1-2 weeks without complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Rare, but potential complications may include secondary bacterial infections like bacterial conjunctivitis or otitis media. In very rare cases, adenovirus can lead to more severe outcomes such as pneumonia or encephalitis.
Picornavirus Infections
Specialty: Infectious Diseases
Category: COVID-19 Reinfections
Symptoms:
fever; muscle aches; headache; sore throat; runny nose; cough; gastrointestinal symptoms (vomiting, diarrhea)
Root Cause:
Picornaviruses (such as enteroviruses and rhinoviruses) cause a range of infections, affecting the respiratory and gastrointestinal systems.
How it's Diagnosed: videos
Diagnosis is confirmed by laboratory tests such as PCR or viral culture. Clinical evaluation is based on symptoms.
Treatment:
Symptomatic treatment is the main approach, including rest, hydration, and use of analgesics or antipyretics to alleviate fever and pain.
Medications:
Symptomatic treatment may include analgesics (e.g., acetaminophen ) and antipyretics (e.g., ibuprofen ) to manage fever and discomfort.
Prevalence:
How common the health condition is within a specific population.
Picornavirus infections are common worldwide, especially in children.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Close contact with infected individuals, crowded living conditions, and compromised immune systems.
Prognosis:
The expected outcome or course of the condition over time.
The infection is usually self-limiting and resolves within a week or two. Most individuals recover fully.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Severe complications are rare but may include meningitis, encephalitis, or respiratory failure, particularly in immunocompromised individuals.
Poliomyelitis
Specialty: Infectious Diseases
Category: COVID-19 Reinfections
Symptoms:
fever; fatigue; headache; muscle weakness; paralysis (in severe cases); neck stiffness
Root Cause:
Poliovirus infects the central nervous system, leading to inflammation of the spinal cord and motor neuron damage, potentially causing paralysis.
How it's Diagnosed: videos
Diagnosis is confirmed through PCR testing or viral culture from stool samples or throat swabs.
Treatment:
There is no specific antiviral treatment for polio. Supportive care, including mechanical ventilation in cases of respiratory failure, and physical therapy to manage muscle weakness, are part of the treatment.
Medications:
No antiviral medications are available for polio. Treatment involves supportive care and pain management (e.g., acetaminophen ).
Prevalence:
How common the health condition is within a specific population.
Polio has been nearly eradicated globally due to vaccination, but outbreaks still occur in regions with low vaccination rates.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Unvaccinated individuals, particularly children in developing countries, are at the highest risk.
Prognosis:
The expected outcome or course of the condition over time.
With early supportive care, the prognosis can be positive for those who do not develop paralysis. Permanent disability can occur in severe cases.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Paralysis, respiratory failure, and death are potential complications. Post-polio syndrome can also occur years after recovery.
Poxviruses
Specialty: Infectious Diseases
Category: COVID-19 Reinfections
Symptoms:
fever; chills; rash (often pimple-like or fluid-filled); fatigue; muscle aches
Root Cause:
Poxviruses (including smallpox, monkeypox) cause skin rashes and systemic infections through direct contact or respiratory transmission.
How it's Diagnosed: videos
Diagnosis is made through clinical evaluation and confirmed with PCR or viral culture.
Treatment:
Treatment is symptomatic, and in some cases, antiviral medications (e.g., tecovirimat for monkeypox) may be used.
Medications:
Tecovirimat , an antiviral medication, is used for treating monkeypox . It is classified as an antiviral medication.
Prevalence:
How common the health condition is within a specific population.
Smallpox has been eradicated; however, monkeypox remains a concern in certain regions, particularly in central and West Africa.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Direct contact with infected animals, people, or contaminated surfaces, as well as compromised immune systems, increase risk.
Prognosis:
The expected outcome or course of the condition over time.
Smallpox has been eradicated, and monkeypox is typically self-limiting, with most patients recovering within a few weeks.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Secondary bacterial infections, pneumonia, and in severe cases, death, particularly in immunocompromised individuals.
Rabies
Specialty: Infectious Diseases
Category: COVID-19 Reinfections
Symptoms:
fever; headache; agitation; hydrophobia (fear of water); paralysis; confusion; delirium; seizures
Root Cause:
Rabies is caused by the rabies virus, which attacks the nervous system, leading to encephalitis and potentially fatal encephalopathy.
How it's Diagnosed: videos
Diagnosis is confirmed by laboratory tests, including PCR, antibody detection, or brain biopsy.
Treatment:
Once symptoms appear, rabies is almost universally fatal. However, post-exposure prophylaxis (PEP) with a rabies vaccine and immunoglobulin can prevent infection if administered promptly after exposure.
Medications:
Rabies vaccine and rabies immunoglobulin (RIG) for post-exposure prophylaxis, classified as immunizations.
Prevalence:
How common the health condition is within a specific population.
Rabies remains a significant issue in developing countries, particularly in Asia and Africa, due to inadequate vaccination in animals.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Animal bites or scratches from infected animals (typically dogs, bats, raccoons).
Prognosis:
The expected outcome or course of the condition over time.
Without treatment, rabies is nearly always fatal after symptoms appear. Early administration of PEP is highly effective.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Once clinical symptoms occur, complications include coma, paralysis, and death.
Reoviruses
Specialty: Infectious Diseases
Category: COVID-19 Reinfections
Symptoms:
fever; diarrhea; vomiting; respiratory symptoms; abdominal cramps
Root Cause:
Reoviruses, such as rotavirus, can cause gastrointestinal and respiratory infections, leading to dehydration and flu-like symptoms.
How it's Diagnosed: videos
Diagnosis is confirmed through stool samples (for rotavirus) or respiratory samples.
Treatment:
Treatment is supportive, focusing on hydration and managing symptoms like fever.
Medications:
Rehydration therapy (oral rehydration salts) and antipyretics (e.g., acetaminophen ).
Prevalence:
How common the health condition is within a specific population.
Reoviruses are common, particularly rotavirus, which affects infants and young children worldwide.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Poor sanitation, lack of vaccination, close contact with infected individuals.
Prognosis:
The expected outcome or course of the condition over time.
The infection is usually self-limiting, but severe dehydration can lead to complications if not treated.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Dehydration, electrolyte imbalances, and in severe cases, death, especially in young children.
Rhinovirus (RV) Infection (Common Cold)
Specialty: Infectious Diseases
Category: COVID-19 Reinfections
Symptoms:
sore throat; runny nose; cough; sneezing; congestion; mild fever; headache; fatigue
Root Cause:
Rhinovirus infects the upper respiratory tract, causing inflammation and an immune response.
How it's Diagnosed: videos
Diagnosis is generally based on symptoms and clinical evaluation. Testing may be performed to confirm the presence of rhinovirus.
Treatment:
Symptomatic treatment with rest, hydration, and over-the-counter medications to relieve symptoms such as pain and congestion.
Medications:
Over-the-counter medications like acetaminophen (a pain reliever and fever reducer), ibuprofen (anti-inflammatory), and decongestants (pseudoephedrine ) can be prescribed to relieve symptoms. These medications fall under analgesics, anti-inflammatory drugs, and decongestants.
Prevalence:
How common the health condition is within a specific population.
Very common, with millions of cases each year worldwide, especially in the fall and winter months.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Exposure to infected individuals, weak immune system, crowded environments, and cold weather.
Prognosis:
The expected outcome or course of the condition over time.
Generally self-limiting with recovery within 7-10 days. Severe cases are rare.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Secondary bacterial infections like sinusitis, ear infections, and bronchitis; exacerbation of pre-existing respiratory conditions like asthma.
Roseola Infantum
Specialty: Infectious Diseases
Category: COVID-19 Reinfections
Symptoms:
high fever; rash that starts on the torso; irritability; swollen lymph nodes; runny nose; diarrhea
Root Cause:
Caused by Human Herpesvirus 6 (HHV-6), which leads to the sudden onset of fever followed by a rash.
How it's Diagnosed: videos
Diagnosis is clinical, often based on the characteristic fever and rash pattern. Blood tests may confirm the presence of HHV-6.
Treatment:
Supportive care with fluids and fever-reducing medications. No specific antiviral treatment is required.
Medications:
Acetaminophen and ibuprofen are often used to control fever. These fall under analgesics and antipyretics.
Prevalence:
How common the health condition is within a specific population.
Affects children aged 6 months to 2 years, with an estimated prevalence of 15-30% in this age group.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Age (most common in infants and toddlers), weakened immune system.
Prognosis:
The expected outcome or course of the condition over time.
Generally mild with full recovery, but rare complications like febrile seizures may occur.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Febrile seizures, secondary infections.
Thogotoviruses/Bourbon Virus
Specialty: Infectious Diseases
Category: COVID-19 Reinfections
Symptoms:
fever; fatigue; muscle aches; headache; nausea; vomiting; rash
Root Cause:
Caused by the Bourbon virus, transmitted by ticks; results in systemic viral infection and immune response.
How it's Diagnosed: videos
Diagnosis is confirmed by PCR testing or serology to detect Bourbon virus antibodies.
Treatment:
Supportive care, including hydration, pain management, and fever control. No specific antiviral treatment.
Medications:
Acetaminophen (analgesic) and ibuprofen (anti-inflammatory) can be used to alleviate symptoms.
Prevalence:
How common the health condition is within a specific population.
Extremely rare, with only a handful of cases reported in the United States.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Tick exposure, rural areas, outdoor activities in tick-endemic regions.
Prognosis:
The expected outcome or course of the condition over time.
Generally mild to moderate disease; however, severe cases may lead to organ failure.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Organ failure, septic shock, death in severe cases.
Upper Respiratory Tract Infection
Specialty: Infectious Diseases
Category: COVID-19 Reinfections
Symptoms:
sore throat; cough; nasal congestion; runny nose; fever; fatigue; headache
Root Cause:
Infection of the nose, sinuses, throat, or larynx, typically caused by viruses like rhinovirus, coronavirus, or influenza.
How it's Diagnosed: videos
Clinical diagnosis based on symptoms; further testing may be done to identify the specific pathogen.
Treatment:
Supportive care, including rest, hydration, and over-the-counter medications for symptom relief.
Medications:
Acetaminophen (analgesic), ibuprofen (anti-inflammatory), decongestants (pseudoephedrine ), and antihistamines (diphenhydramine ) can be used for symptom management.
Prevalence:
How common the health condition is within a specific population.
Very common, with millions of cases annually worldwide.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Exposure to infected individuals, crowded environments, weak immune system.
Prognosis:
The expected outcome or course of the condition over time.
Typically self-limiting, with symptoms resolving in 7-10 days.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Secondary bacterial infections like sinusitis, bronchitis, and pneumonia.