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Category:

Pediatric Exanthems

Number of Conditions: 1

Asymmetric Periflexural Exanthem of Childhood (APEC)

Symptoms:
unilateral rash in skin folds or flexural areas; erythematous or papular lesions; mild itching or discomfort; no systemic symptoms like fever

Root Cause:
Likely caused by a viral infection, although the exact pathogen is unknown. Immune response to an antigen may play a role.

How it's Diagnosed: videos
Clinical observation of the characteristic rash; no specific laboratory tests are needed.

Treatment:
Supportive care with topical emollients or antihistamines for itching; resolves spontaneously in 4–6 weeks.

Medications:
Antihistamines (e.g., cetirizine , loratadine for itching) and topical emollients (e.g., petroleum jelly, glycerin-based creams).

Prevalence: How common the health condition is within a specific population.
Rare; affects children aged 1–5 years, with isolated case reports in the medical literature.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Viral infections, childhood age, exposure to viral antigens.

Prognosis: The expected outcome or course of the condition over time.
Excellent; rash resolves without scarring or recurrence.

Complications: Additional problems or conditions that may arise as a result of the original condition.
No significant complications; mild itching may cause temporary discomfort.