Comprehensive Symptom Navigator™
Your health assistant, simplified.
Disclaimer: This is just an assistant. It should not be used for diagnosing patients without a doctor's discretion.
Symptoms:
Number of Conditions: 111
Diabetic Ketoacidosis (DKA)
Specialty: Diabetes and Endocrinology
Category: Diabetes Mellitus and Related Disorders
Sub-category: Acute Complications
Symptoms:
excessive thirst; frequent urination; nausea; vomiting; abdominal pain; shortness of breath; fruity-smelling breath; confusion
Root Cause:
Insulin deficiency leads to uncontrolled hyperglycemia, lipolysis, and ketone production, causing metabolic acidosis.
How it's Diagnosed: videos
Blood tests showing high blood glucose, ketonemia, low bicarbonate, and arterial blood pH < 7.3; urine tests for ketones.
Treatment:
Intravenous fluids, insulin therapy, electrolyte replacement (potassium), and treating underlying causes (e.g., infection).
Medications:
Regular insulin administered intravenously to reduce blood glucose and ketone levels.
Prevalence:
How common the health condition is within a specific population.
Common in individuals with type 1 diabetes; can occur in type 2 diabetes during severe stress.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Poor diabetes management, infection, trauma, surgery, or missed insulin doses.
Prognosis:
The expected outcome or course of the condition over time.
Early treatment leads to recovery; delayed treatment may result in coma or death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Cerebral edema, hypokalemia, arrhythmias, and death.
Concussion and Traumatic Brain Injury (TBI)
Specialty: Emergency and Urgent Care
Category: Trauma and Injuries
Sub-category: Blunt Trauma
Symptoms:
headache; confusion; dizziness; nausea; vomiting; temporary loss of consciousness; difficulty concentrating; memory problems; sleep disturbances; mood changes
Root Cause:
Disruption in normal brain function due to a direct blow, jolt, or penetrating injury to the head causing mechanical damage to brain tissue.
How it's Diagnosed: videos
Clinical evaluation, Glasgow Coma Scale (GCS), neurological exam, imaging studies (CT scan or MRI).
Treatment:
Rest, symptom management, physical and cognitive rehabilitation, and monitoring for complications.
Medications:
Pain relievers (acetaminophen ), anti-nausea medications, and sometimes anticonvulsants (e.g., phenytoin ) or diuretics (e.g., mannitol ) to reduce intracranial pressure.
Prevalence:
How common the health condition is within a specific population.
Millions of cases worldwide annually, with mild TBI (concussion) being the most common.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Sports injuries, motor vehicle accidents, falls, and assaults.
Prognosis:
The expected outcome or course of the condition over time.
Most mild TBIs resolve with proper care; severe TBIs may result in lasting neurological deficits or disability.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Post-concussion syndrome, chronic traumatic encephalopathy (CTE), seizures, and long-term cognitive or psychological impairments.
Cardiogenic shock
Specialty: Trauma and Injuries
Category: Other Trauma-Related Conditions
Sub-category: Complications of Trauma
Symptoms:
low blood pressure; rapid heart rate; weak pulse; shortness of breath; cold, clammy skin; decreased urine output; confusion
Root Cause:
The heart is unable to pump sufficient blood to meet the body’s needs, usually due to severe heart damage (e.g., from a heart attack).
How it's Diagnosed: videos
Diagnosis includes clinical assessment, echocardiography, ECG, blood tests (e.g., cardiac enzymes), and imaging to assess heart function.
Treatment:
Treatment includes medications (inotropes, vasopressors), mechanical support devices (e.g., intra-aortic balloon pump), and, in some cases, surgical interventions to treat the underlying cause (e.g., coronary artery bypass).
Medications:
Inotropes (e.g., dobutamine , dopamine) to improve heart contractility, vasopressors (e.g., norepinephrine ) to increase blood pressure, and anticoagulants may be used to prevent blood clots.
Prevalence:
How common the health condition is within a specific population.
Affects approximately 1-2% of patients with acute myocardial infarction (heart attack).
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
History of heart disease, prior heart attacks, coronary artery disease, diabetes, hypertension.
Prognosis:
The expected outcome or course of the condition over time.
The prognosis depends on the severity of heart damage and the timeliness of treatment. Without prompt intervention, cardiogenic shock can be fatal.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Organ failure, arrhythmias, multi-organ dysfunction, and death.
Hypertensive Emergencies
Specialty: Emergency and Urgent Care
Category: Cardiac Emergencies
Sub-category: Hypertension-related Conditions
Symptoms:
severe headache; chest pain; shortness of breath; blurred vision; confusion; nausea or vomiting; seizures
Root Cause:
Critically elevated blood pressure (typically >180/120 mmHg) causing acute end-organ damage (e.g., heart, brain, kidneys, or eyes).
How it's Diagnosed: videos
Blood pressure measurement, clinical signs of end-organ damage, lab tests (renal function, electrolytes), and imaging (e.g., CT for stroke, ECG for cardiac involvement).
Treatment:
Immediate blood pressure reduction using intravenous antihypertensives and addressing the specific end-organ damage.
Medications:
IV antihypertensives like nitroprusside (vasodilator), labetalol (beta-blocker), nicardipine (calcium channel blocker), or hydralazine . Oral antihypertensives are introduced later.
Prevalence:
How common the health condition is within a specific population.
Occurs in about 1-2% of patients with chronic hypertension.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Poorly controlled hypertension, noncompliance with antihypertensive medications, kidney disease, and pregnancy (e.g., eclampsia).
Prognosis:
The expected outcome or course of the condition over time.
Depends on promptness of treatment; delayed care can result in severe complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Stroke, myocardial infarction, aortic dissection, acute kidney injury, and retinal damage.
COVID-19 Complications
Specialty: Emergency and Urgent Care
Category: Respiratory Emergencies
Sub-category: Infectious Respiratory Conditions
Symptoms:
severe shortness of breath; high fever; persistent cough; chest pain; hypoxia; confusion; fatigue; multisystem organ failure; loss of taste or smell
Root Cause:
Severe respiratory distress or systemic involvement caused by the SARS-CoV-2 virus, leading to complications such as ARDS (acute respiratory distress syndrome), thromboembolic events, or cytokine storm.
How it's Diagnosed: videos
Positive RT-PCR or antigen test for SARS-CoV-2, chest imaging (X-ray or CT), blood tests (D-dimer, CRP, ferritin), and pulse oximetry or arterial blood gas analysis.
Treatment:
Supportive care (oxygen therapy, ventilators for severe cases), antiviral drugs (e.g., remdesivir), anti-inflammatory treatments like dexamethasone, anticoagulants, and immunomodulators.
Medications:
Antivirals such as remdesivir (antiviral), corticosteroids like dexamethasone (anti-inflammatory), anticoagulants like enoxaparin (anticoagulant), and monoclonal antibodies like tocilizumab (immunomodulator).
Prevalence:
How common the health condition is within a specific population.
Global pandemic with millions affected; complications occur in approximately 10-15% of cases, particularly in those with comorbidities.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Older age, obesity, diabetes, hypertension, cardiovascular disease, and immunosuppression.
Prognosis:
The expected outcome or course of the condition over time.
Varies widely; mild cases recover fully, while severe cases may result in prolonged hospitalization, long-term organ damage, or death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
ARDS, sepsis, thromboembolic events (e.g., pulmonary embolism), myocarditis, kidney failure, and long COVID symptoms like fatigue and brain fog.
Ischemic Stroke
Specialty: Neurology
Category: Cerebrovascular Diseases
Symptoms:
sudden weakness or numbness, especially on one side of the body; confusion; trouble speaking or understanding speech; vision problems; difficulty walking; dizziness; severe headache without known cause
Root Cause:
Blockage of blood flow to the brain due to a blood clot or atherosclerosis, leading to reduced oxygen supply and cell death.
How it's Diagnosed: videos
Neurological examination, CT scan or MRI of the brain, carotid ultrasound, echocardiography, and blood tests for clotting factors and cholesterol.
Treatment:
Emergency treatment with thrombolytic therapy (e.g., alteplase), mechanical thrombectomy, blood thinners, and management of underlying risk factors such as hypertension and high cholesterol. Rehabilitation follows.
Medications:
Thrombolytics like alteplase (tissue plasminogen activator, or tPA) are used in acute cases; antiplatelet drugs (e.g., aspirin , clopidogrel ) and anticoagulants (e.g., warfarin , dabigatran ) are prescribed for long-term prevention. Statins (e.g., atorvastatin , rosuvastatin ) may also be used.
Prevalence:
How common the health condition is within a specific population.
Approximately 87% of all strokes are ischemic strokes; incidence increases with age.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Hypertension, diabetes, smoking, high cholesterol, obesity, atrial fibrillation, and family history of stroke.
Prognosis:
The expected outcome or course of the condition over time.
Early treatment improves outcomes, with recovery dependent on the extent and location of the brain damage. Rehabilitation plays a critical role.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Permanent neurological deficits, recurrent strokes, post-stroke depression, and increased risk of infections like pneumonia.
New-Onset Seizures
Specialty: Emergency and Urgent Care
Category: Neurological Emergencies
Sub-category: Seizures
Symptoms:
sudden loss of consciousness; uncontrolled jerking movements; confusion; loss of bladder or bowel control; aura (sensory or perceptual disturbances); postictal state of confusion or drowsiness
Root Cause:
Abnormal electrical activity in the brain due to various potential causes, including head trauma, infections, electrolyte imbalances, structural brain abnormalities, or unknown (idiopathic).
How it's Diagnosed: videos
History and physical examination, EEG to assess brain activity, blood tests to rule out metabolic triggers, and imaging (MRI or CT) to identify structural causes or lesions.
Treatment:
Immediate stabilization, treating any identified underlying cause, and, in some cases, starting antiepileptic medications.
Medications:
Treatment may involve levetiracetam , phenytoin , valproic acid, or lamotrigine (anticonvulsants). Medications are selected based on the seizure type and patient profile.
Prevalence:
How common the health condition is within a specific population.
About 40-70 cases per 100,000 individuals annually, with higher incidence in children and the elderly.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Head trauma, CNS infections, metabolic disturbances, drug intoxication or withdrawal, and family history of epilepsy.
Prognosis:
The expected outcome or course of the condition over time.
Variable; some cases resolve after treating the underlying cause, while others may lead to a diagnosis of epilepsy. Early diagnosis and treatment improve outcomes.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Risk of recurrent seizures, progression to status epilepticus, injury during seizures, and psychological effects such as anxiety or depression.
Encephalitis
Specialty: Emergency and Urgent Care
Category: Neurological Emergencies
Sub-category: Infectious Neurological Conditions
Symptoms:
fever; headache; altered consciousness; seizures; confusion; weakness; speech difficulties
Root Cause:
Inflammation of brain parenchyma, often caused by viral infections (e.g., herpes simplex virus) or autoimmune processes.
How it's Diagnosed: videos
Clinical history, imaging (MRI), lumbar puncture (CSF analysis), EEG, and PCR testing for viral DNA/RNA.
Treatment:
Antiviral therapy, immunomodulatory therapy (if autoimmune), supportive care for seizures and intracranial pressure.
Medications:
Acyclovir (antiviral for herpes simplex encephalitis ), corticosteroids or intravenous immunoglobulin (IVIG) for autoimmune encephalitis .
Prevalence:
How common the health condition is within a specific population.
5–10 cases per 100,000 annually worldwide.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Immunosuppression, travel to endemic areas, mosquito or tick bites, young or elderly age.
Prognosis:
The expected outcome or course of the condition over time.
Variable; early treatment improves outcomes, but neurological sequelae may persist in severe cases.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Cognitive deficits, motor dysfunction, seizures, and death in severe cases.
Diabetic ketoacidosis (DKA)
Specialty: Emergency and Urgent Care
Category: Endocrine and Metabolic Emergencies
Sub-category: Diabetes-Related Emergencies
Symptoms:
nausea; vomiting; abdominal pain; rapid breathing; fruity-scented breath; confusion; excessive thirst; frequent urination
Root Cause:
DKA occurs due to insufficient insulin, leading to uncontrolled hyperglycemia, ketone production, and metabolic acidosis.
How it's Diagnosed: videos
Clinical evaluation, laboratory tests showing hyperglycemia (blood glucose >250 mg/dL), ketonemia, ketonuria, low bicarbonate levels (<18 mEq/L), and an elevated anion gap metabolic acidosis.
Treatment:
Immediate fluid resuscitation (IV fluids), insulin therapy, electrolyte replacement (especially potassium), and addressing precipitating factors (e.g., infections).
Medications:
Regular insulin (short-acting insulin for IV infusion to lower blood glucose and suppress ketone production), potassium supplements (for electrolyte correction), bicarbonate (in severe acidosis cases, though used cautiously).
Prevalence:
How common the health condition is within a specific population.
Common in individuals with type 1 diabetes and occasionally in type 2 diabetes under stress or illness.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Poor diabetes management, infections, physical or emotional stress, skipping insulin doses, undiagnosed diabetes.
Prognosis:
The expected outcome or course of the condition over time.
Favorable if treated promptly; mortality is low with appropriate intervention but rises if untreated.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Cerebral edema (especially in children), hypokalemia, cardiac arrhythmias, hypoglycemia, and multi-organ failure in severe cases.
Severe hypoglycemia
Specialty: Emergency and Urgent Care
Category: Endocrine and Metabolic Emergencies
Sub-category: Diabetes-Related Emergencies
Symptoms:
shakiness; sweating; palpitations; confusion; irritability; seizures; loss of consciousness; coma
Root Cause:
Blood glucose levels drop dangerously low (<54 mg/dL) due to excess insulin, inadequate food intake, or increased physical activity.
How it's Diagnosed: videos
Confirmed by measuring blood glucose (<70 mg/dL, with severe symptoms typically at <54 mg/dL) and rapid resolution of symptoms after glucose administration.
Treatment:
Immediate administration of glucose (oral if conscious, IV dextrose if unconscious), glucagon injection for emergencies, and addressing underlying causes.
Medications:
Dextrose (IV infusion to rapidly raise blood glucose), glucagon (injectable for emergency situations), and long-term adjustments to insulin regimens or oral diabetes medications.
Prevalence:
How common the health condition is within a specific population.
Frequent in individuals with diabetes on insulin or sulfonylureas, especially in those with tight glucose control.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Insulin or sulfonylurea use, skipping meals, excessive alcohol consumption, prolonged fasting, or physical exertion.
Prognosis:
The expected outcome or course of the condition over time.
Recovery is rapid with appropriate treatment; recurrent episodes can lead to impaired awareness of hypoglycemia.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Seizures, loss of consciousness, brain damage from prolonged severe hypoglycemia, and potential cardiovascular events.
Hyponatremia
Specialty: Nephrology
Category: Electrolyte and Acid-Base Disorders
Symptoms:
nausea; vomiting; confusion; headache; seizures; fatigue; restlessness; muscle weakness or spasms; coma in severe cases
Root Cause:
Low sodium concentration in the blood, often caused by excessive water retention, sodium loss, or a combination of both.
How it's Diagnosed: videos
Blood tests measuring serum sodium levels (<135 mEq/L), urine sodium and osmolality, and clinical evaluation of symptoms.
Treatment:
Treatment focuses on addressing the underlying cause, restricting fluid intake, or administering sodium supplementation. Severe cases may require hypertonic saline.
Medications:
Tolvaptan or conivaptan (vasopressin receptor antagonists), diuretics like loop diuretics (e.g., furosemide ) for certain cases, and sodium chloride for supplementation.
Prevalence:
How common the health condition is within a specific population.
Common, particularly in hospitalized patients; estimated at 15–30% in such settings.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Heart failure, liver cirrhosis, kidney disease, SIADH, use of diuretics, excessive water intake, and advanced age.
Prognosis:
The expected outcome or course of the condition over time.
Generally good if treated promptly, but severe hyponatremia can lead to permanent neurological damage or death if untreated.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Cerebral edema, seizures, coma, central pontine myelinolysis (from overly rapid correction).
Hypercalcemia
Specialty: Nephrology
Category: Electrolyte and Acid-Base Disorders
Symptoms:
nausea; vomiting; constipation; polyuria; kidney stones; confusion; lethargy; arrhythmias
Root Cause:
Elevated calcium levels in the blood due to increased bone resorption, excessive intake, or abnormal regulation by parathyroid hormone.
How it's Diagnosed: videos
Blood tests showing serum calcium >10.5 mg/dL, PTH levels, and clinical evaluation of symptoms.
Treatment:
IV fluids, bisphosphonates, calcitonin, and addressing the underlying cause (e.g., surgery for hyperparathyroidism).
Medications:
Bisphosphonates (e.g., pamidronate , zoledronic acid), calcitonin (reduces calcium levels), and corticosteroids for specific conditions.
Prevalence:
How common the health condition is within a specific population.
Common, particularly in patients with malignancy or hyperparathyroidism.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Hyperparathyroidism, malignancy, excessive calcium/vitamin D intake, and prolonged immobility.
Prognosis:
The expected outcome or course of the condition over time.
Good with proper treatment; severe hypercalcemia can lead to renal failure or cardiac arrest.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Kidney stones, nephrocalcinosis, arrhythmias, and neuropsychiatric disturbances.
Severe Dehydration
Specialty: Emergency and Urgent Care
Category: Endocrine and Metabolic Emergencies
Sub-category: Fluid and Volume Imbalances
Symptoms:
extreme thirst; dry mucous membranes; sunken eyes; tachycardia; hypotension; reduced urine output; confusion; lethargy
Root Cause:
Excessive fluid loss or inadequate intake leading to significant extracellular volume depletion and impaired organ perfusion.
How it's Diagnosed: videos
Clinical assessment (skin turgor, mucous membranes), blood tests (elevated hematocrit, blood urea nitrogen), and urine tests (concentrated urine, high specific gravity).
Treatment:
Rapid fluid resuscitation with isotonic crystalloids (e.g., normal saline or lactated Ringer's), correction of electrolyte imbalances, and treatment of underlying cause.
Medications:
IV fluids (normal saline or lactated Ringer's); electrolyte replacement as needed (potassium, magnesium, or sodium bicarbonate).
Prevalence:
How common the health condition is within a specific population.
Common globally, particularly in cases of severe diarrhea, vomiting, or heat exposure.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Diarrhea, vomiting, burns, excessive sweating, and diuretic use.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with timely treatment; delayed treatment can lead to shock and multi-organ failure.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Hypovolemic shock, acute kidney injury, and electrolyte disturbances.
Acute Kidney Injury (AKI)
Specialty: Nephrology
Category: Chronic and Acute Kidney Diseases
Symptoms:
decreased urine output; swelling in legs, ankles, or feet; nausea; confusion; fatigue; chest pain or pressure; shortness of breath
Root Cause:
Sudden loss of kidney function due to reduced blood flow, damage to kidney tissue, or blockage of urinary outflow.
How it's Diagnosed: videos
Blood tests (e.g., elevated creatinine), decreased urine output, and imaging studies to identify potential obstructions.
Treatment:
Addressing the underlying cause, restoring fluid balance, removing toxins, and temporary dialysis if needed.
Medications:
Medications may include diuretics (e.g., furosemide ), electrolyte binders (e.g., sodium polystyrene sulfonate ), and vasopressors in cases of low blood pressure.
Prevalence:
How common the health condition is within a specific population.
Occurs in approximately 20% of hospitalized patients; higher risk in critical care settings.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Advanced age, pre-existing kidney disease, diabetes, sepsis, major surgery, or exposure to nephrotoxic drugs.
Prognosis:
The expected outcome or course of the condition over time.
Variable; reversible in many cases, but severe or prolonged AKI can lead to chronic kidney damage or failure.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Electrolyte imbalances, fluid overload, chronic kidney disease, and increased risk of mortality.
Uremia
Specialty: Emergency and Urgent Care
Category: Renal and Urologic Emergencies
Sub-category: Renal Failure Complications
Symptoms:
nausea; vomiting; loss of appetite; fatigue; confusion; seizures; muscle cramps; itching; fluid retention; shortness of breath; high blood pressure; altered mental status
Root Cause:
Accumulation of urea and other nitrogenous waste products in the blood due to impaired kidney function. This condition arises from chronic or acute renal failure, leading to toxic effects on multiple organ systems.
How it's Diagnosed: videos
Blood tests showing elevated blood urea nitrogen (BUN) and creatinine levels, electrolyte imbalances, and metabolic acidosis; urinalysis may indicate proteinuria or hematuria; imaging (ultrasound or CT) may show kidney abnormalities. Clinical symptoms and history are also critical.
Treatment:
Emergency treatment includes dialysis (hemodialysis or peritoneal dialysis) to remove waste products and restore electrolyte balance. Supportive care includes addressing fluid overload and managing complications such as hypertension and metabolic acidosis.
Medications:
Diuretics (e.g., furosemide )
Prevalence:
How common the health condition is within a specific population.
Common among individuals with advanced chronic kidney disease (CKD) or acute kidney injury (AKI); incidence rises in end-stage renal disease (ESRD) patients.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Chronic kidney disease, acute kidney injury, diabetes mellitus, hypertension, advanced age, polycystic kidney disease, and autoimmune disorders affecting the kidneys (e.g., lupus nephritis).
Prognosis:
The expected outcome or course of the condition over time.
With timely dialysis and treatment, symptoms can be managed effectively; however, the underlying renal disease usually remains progressive without a transplant. Untreated uremia is life-threatening.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Cardiac arrhythmias, pericarditis, seizures, encephalopathy, fluid overload, and death if untreated.
Severe Electrolyte Imbalances
Specialty: Emergency and Urgent Care
Category: Renal and Urologic Emergencies
Sub-category: Electrolyte Disorders
Symptoms:
muscle weakness; cramps; nausea; confusion; seizures; cardiac arrhythmias; paralysis; fatigue; tetany; altered mental status
Root Cause:
Abnormal levels of critical electrolytes such as potassium, sodium, calcium, magnesium, and phosphate in the blood, resulting from renal dysfunction, medications, endocrine disorders, or fluid imbalance.
How it's Diagnosed: videos
Blood tests for electrolyte levels, arterial blood gas analysis for acid-base status, and ECG to detect arrhythmias. History and clinical examination are also key.
Treatment:
Depends on the specific electrolyte imbalance
Medications:
Calcium supplements (e.g., calcium gluconate)
Prevalence:
How common the health condition is within a specific population.
Common in hospitalized patients, particularly those with kidney disease, heart failure, or endocrine disorders.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Chronic kidney disease, diuretics, excessive fluid loss, endocrine disorders (e.g., diabetes insipidus, SIADH), and critical illnesses.
Prognosis:
The expected outcome or course of the condition over time.
With prompt recognition and treatment, outcomes are typically favorable; however, severe imbalances can cause life-threatening complications if untreated.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Cardiac arrest, respiratory failure, seizures, neuromuscular dysfunction, and multi-organ failure.
Toxic Shock Syndrome
Specialty: Emergency and Urgent Care
Category: Infectious Diseases
Sub-category: Other Infectious Emergencies
Symptoms:
sudden high fever; low blood pressure; vomiting; diarrhea; rash resembling sunburn; confusion; seizures; muscle aches; redness of eyes, throat, and mouth; organ failure
Root Cause:
Caused by toxins produced by Staphylococcus aureus or Streptococcus pyogenes bacteria, often associated with tampon use, wound infections, or surgical procedures.
How it's Diagnosed: videos
Clinical evaluation based on symptoms, blood cultures, and other laboratory tests to identify the bacterial toxin.
Treatment:
Immediate hospitalization, intravenous fluids to maintain blood pressure, antibiotics to target bacteria, and management of organ dysfunction.
Medications:
Intravenous antibiotics such as clindamycin and vancomycin (antibacterials). IV immunoglobulins may also be used to neutralize toxins.
Prevalence:
How common the health condition is within a specific population.
Rare, with an incidence of approximately 1–2 cases per 100,000 population annually.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Prolonged tampon use, post-surgical infections, open wounds, childbirth, or nasal packing.
Prognosis:
The expected outcome or course of the condition over time.
Good with prompt treatment; however, untreated cases can be fatal.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Shock, organ failure, amputations due to necrosis, and death.
Acetaminophen overdose
Specialty: Emergency and Urgent Care
Category: Toxicology and Overdose
Sub-category: Drug Overdoses
Symptoms:
nausea; vomiting; abdominal pain; confusion; jaundice (late stage); elevated liver enzymes
Root Cause:
Excessive acetaminophen overwhelms the liver's ability to conjugate and detoxify NAPQI (toxic metabolite), causing hepatocellular damage.
How it's Diagnosed: videos
History of overdose, serum acetaminophen levels, and liver function tests (LFTs); use of the Rumack-Matthew nomogram for risk assessment.
Treatment:
N-acetylcysteine (NAC) administration (oral or IV) to replenish glutathione, activated charcoal if within 1-2 hours of ingestion, and supportive care.
Medications:
N-acetylcysteine (antidote for acetaminophen toxicity) and activated charcoal (gastric decontaminant).
Prevalence:
How common the health condition is within a specific population.
Acetaminophen toxicity is one of the most common causes of drug overdoses globally and a leading cause of acute liver failure in the U.S.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Chronic acetaminophen use, concurrent alcohol consumption, pre-existing liver disease, and taking higher-than-recommended doses.
Prognosis:
The expected outcome or course of the condition over time.
Good with early treatment; delayed treatment increases the risk of liver failure, necessitating a liver transplant.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Acute liver failure, metabolic acidosis, encephalopathy, and death.
Benzodiazepine overdose
Specialty: Emergency and Urgent Care
Category: Toxicology and Overdose
Sub-category: Drug Overdoses
Symptoms:
drowsiness; slurred speech; confusion; hypotension; respiratory depression (rare if taken alone); ataxia
Root Cause:
Excessive potentiation of GABA-A receptors leads to central nervous system depression.
How it's Diagnosed: videos
History of overdose, clinical presentation, and urine toxicology testing.
Treatment:
Supportive care (airway management, IV fluids), flumazenil (benzodiazepine receptor antagonist) in selective cases, and monitoring for respiratory depression.
Medications:
Flumazenil , a benzodiazepine receptor antagonist, used cautiously due to the risk of seizures in chronic users.
Prevalence:
How common the health condition is within a specific population.
Common due to the widespread prescription and misuse of benzodiazepines; often co-ingested with other substances like alcohol or opioids.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Polypharmacy, substance use disorder, underlying mental health issues, and unsupervised access to medications.
Prognosis:
The expected outcome or course of the condition over time.
Generally good if treated promptly; co-ingestion with other CNS depressants worsens outcomes.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Respiratory failure, coma, aspiration pneumonia, and death.
Alcohol poisoning
Specialty: Emergency and Urgent Care
Category: Toxicology and Overdose
Sub-category: Substance Abuse
Symptoms:
confusion; vomiting; hypothermia; seizures; slow or irregular breathing; unconsciousness
Root Cause:
Excessive ethanol consumption depresses the central nervous system, impairs respiratory function, and leads to metabolic acidosis.
How it's Diagnosed: videos
Clinical presentation, serum ethanol levels, and assessment for metabolic derangements (ABG, electrolyte panel).
Treatment:
Airway protection, intravenous fluids, thiamine and glucose supplementation, and monitoring in an intensive care setting.
Medications:
Thiamine (to prevent Wernicke-Korsakoff syndrome) and glucose (to address hypoglycemia). No direct antidote for ethanol toxicity.
Prevalence:
How common the health condition is within a specific population.
Alcohol poisoning is a frequent emergency, especially among binge drinkers; accounts for thousands of deaths annually worldwide.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Binge drinking, alcohol use disorder, low body weight, and concurrent use of sedatives or opioids.
Prognosis:
The expected outcome or course of the condition over time.
Good with early intervention; severe cases can result in brain damage or death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Hypoglycemia, hypothermia, aspiration, respiratory depression, and death.
Carbon Monoxide Poisoning
Specialty: Emergency and Urgent Care
Category: Toxicology and Overdose
Sub-category: Chemical Exposures
Symptoms:
headache; dizziness; nausea; shortness of breath; confusion; loss of consciousness; chest pain; seizures
Root Cause:
Carbon monoxide binds to hemoglobin with a higher affinity than oxygen, reducing oxygen delivery to tissues and causing hypoxia.
How it's Diagnosed: videos
Measurement of carboxyhemoglobin levels in blood using co-oximetry, pulse CO-oximeter, or arterial blood gas analysis. Symptoms and exposure history also aid diagnosis.
Treatment:
Immediate removal from the CO exposure source, 100% oxygen therapy through a non-rebreather mask, or hyperbaric oxygen therapy in severe cases.
Medications:
No direct medications, but 100% oxygen therapy and hyperbaric oxygen are the main treatments. Hyperbaric oxygen is classified as a high-pressure oxygen delivery treatment.
Prevalence:
How common the health condition is within a specific population.
A leading cause of poisoning-related deaths worldwide, with an estimated 50,000 emergency department visits annually in the U.S.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Poorly ventilated spaces, faulty heating systems, exposure to fires, and use of charcoal or gas grills indoors.
Prognosis:
The expected outcome or course of the condition over time.
Good with timely treatment; delayed or severe exposure may lead to long-term neurological complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Neurological sequelae (e.g., memory loss, difficulty concentrating), myocardial ischemia, arrhythmias, and death.
Cyanide Poisoning
Specialty: Emergency and Urgent Care
Category: Toxicology and Overdose
Sub-category: Chemical Exposures
Symptoms:
shortness of breath; confusion; headache; nausea; seizures; loss of consciousness; cardiac arrest
Root Cause:
Cyanide inhibits cytochrome oxidase in mitochondria, blocking cellular respiration and leading to rapid tissue hypoxia.
How it's Diagnosed: videos
Clinical suspicion based on exposure history, measurement of cyanide levels in blood, arterial blood gas showing metabolic acidosis with high lactate.
Treatment:
Administration of specific antidotes (e.g., hydroxocobalamin, sodium thiosulfate) and supportive care, including oxygen therapy and mechanical ventilation if needed.
Medications:
Hydroxocobalamin (binds cyanide to form cyanocobalamin , excreted in urine), Sodium thiosulfate (enhances cyanide metabolism to thiocyanate), and Nitrites (to induce methemoglobin formation, binding cyanide). These are classified as antidotes.
Prevalence:
How common the health condition is within a specific population.
Rare in the general population but associated with industrial exposures, smoke inhalation from fires, and deliberate ingestion.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Exposure to industrial chemicals, smoke inhalation from fires, ingestion of cyanogenic compounds (e.g., amygdalin in apricot seeds).
Prognosis:
The expected outcome or course of the condition over time.
Excellent with early and appropriate treatment; poor prognosis in delayed or severe cases without intervention.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Hypoxic brain injury, multi-organ failure, and death.
Delirium Tremens
Specialty: Emergency and Urgent Care
Category: Psychiatric and Behavioral Emergencies
Sub-category: Substance-Related Crises
Symptoms:
severe agitation; confusion; hallucinations; fever; sweating; tachycardia; hypertension; seizures
Root Cause:
Acute severe alcohol withdrawal resulting in central nervous system hyperactivity, involving dysregulated neurotransmitter activity (reduced GABA and excessive glutamate).
How it's Diagnosed: videos
Clinical evaluation based on history of alcohol use, presenting symptoms, and ruling out other causes of delirium through lab tests and imaging if necessary.
Treatment:
High-dose benzodiazepines, IV fluids, thiamine, magnesium, and antipsychotics for severe agitation or psychosis. ICU-level monitoring may be required for severe cases.
Medications:
Benzodiazepines (e.g., lorazepam , diazepam , chlordiazepoxide ) are used for sedation and symptom control. Antipsychotics (e.g., haloperidol ) may help with hallucinations or severe agitation. Thiamine to prevent or treat Wernicke's encephalopathy.
Prevalence:
How common the health condition is within a specific population.
Occurs in 5% of patients undergoing alcohol withdrawal; more common in individuals with chronic, severe alcohol dependence.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Long-term heavy alcohol use, history of delirium tremens, concurrent medical illness, and poor nutritional status.
Prognosis:
The expected outcome or course of the condition over time.
Life-threatening if untreated; with aggressive treatment, the prognosis improves significantly, but mortality still ranges from 1-4%.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Arrhythmias, respiratory failure, aspiration pneumonia, cardiovascular collapse, and Wernicke-Korsakoff syndrome.
Drug-Induced Psychosis
Specialty: Emergency and Urgent Care
Category: Psychiatric and Behavioral Emergencies
Sub-category: Substance-Related Crises
Symptoms:
paranoia; hallucinations (auditory or visual); delusions; disorganized thinking; agitation; confusion
Root Cause:
Acute or chronic use of psychoactive substances disrupts neurotransmitter systems (e.g., dopamine, serotonin) in the brain, leading to psychosis.
How it's Diagnosed: videos
Clinical evaluation of symptoms, history of substance use, and toxicology screening to identify causative substances.
Treatment:
Immediate cessation of the causative drug, supportive care, and symptomatic treatment with antipsychotics or sedatives as needed.
Medications:
Antipsychotics (e.g., haloperidol , olanzapine ) are used to manage psychotic symptoms. Benzodiazepines (e.g., lorazepam ) for agitation or severe distress.
Prevalence:
How common the health condition is within a specific population.
Common among individuals using stimulants (e.g., methamphetamine, cocaine), hallucinogens, or cannabis; prevalence varies by substance and population.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Use of high doses of psychoactive substances, preexisting mental health conditions, genetic predisposition, and poly-drug use.
Prognosis:
The expected outcome or course of the condition over time.
Usually resolves with cessation of the causative substance, but prolonged psychosis may occur in some cases, especially with chronic use.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Self-harm, aggression, chronic psychotic disorders, and substance dependency.
Hypothermia
Specialty: Senior Health and Geriatrics
Category: Miscellaneous Age-Related Conditions
Sub-category: Thermoregulatory Disorders
Symptoms:
shivering; confusion; slurred speech; drowsiness; weak pulse; low body temperature; pale skin; loss of coordination
Root Cause:
The body loses heat faster than it can produce it, causing the body temperature to drop below the normal range (95°F or 35°C). In older adults, the body's thermoregulation becomes less efficient, increasing the risk.
How it's Diagnosed: videos
Diagnosis is primarily clinical, supported by the measurement of body temperature. Other diagnostic tests may include blood tests and ECG to assess for complications such as arrhythmias.
Treatment:
The primary treatment involves rewarming the body using passive or active methods, such as warm blankets, heating pads, or immersion in warm water. Intravenous fluids and, in severe cases, warm, humidified oxygen or rewarming devices may be used. Hospitalization is often required in severe cases.
Medications:
No specific medications are used to treat hypothermia directly. However, if complications such as infection or dehydration occur, antibiotics and intravenous fluids may be prescribed. In case of cardiac arrhythmias, anti-arrhythmic medications (e.g., amiodarone ) may be used.
Prevalence:
How common the health condition is within a specific population.
Hypothermia is more common in elderly individuals, particularly those who are frail, have chronic health conditions, or live in poorly insulated environments. It is more common during winter months.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Advanced age, poor circulation, malnutrition, certain medications (such as sedatives or antidepressants), and environmental factors (cold weather, wet clothing).
Prognosis:
The expected outcome or course of the condition over time.
With prompt and effective treatment, many individuals recover without lasting effects. However, severe cases can lead to organ failure and death if not treated in time.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Severe hypothermia can cause heart arrhythmias, organ failure, frostbite, respiratory failure, and even death if not managed properly.
Acute Respiratory Distress Syndrome (ARDS)
Specialty: Pulmonology
Category: Respiratory Failure and Critical Care
Symptoms:
severe shortness of breath; rapid breathing; low blood oxygen levels; fatigue; confusion; cyanosis (bluish skin)
Root Cause:
ARDS is caused by widespread inflammation in the lungs, leading to fluid buildup in the alveoli, preventing normal gas exchange.
How it's Diagnosed: videos
Diagnosis is based on clinical presentation, arterial blood gas (ABG) analysis, chest X-ray (showing bilateral pulmonary infiltrates), and exclusion of other causes of hypoxemia.
Treatment:
Supportive care with mechanical ventilation, use of positive end-expiratory pressure (PEEP), fluid management, and addressing the underlying cause (e.g., infection, trauma).
Medications:
Medications used in ARDS may include sedatives (e.g., propofol , lorazepam ), analgesics (e.g., morphine , fentanyl ), corticosteroids (e.g., methylprednisolone for inflammation), and antibiotics if infection is the cause. These are classified as sedatives, analgesics, corticosteroids, and antibiotics.
Prevalence:
How common the health condition is within a specific population.
ARDS affects approximately 10-15% of critically ill patients in intensive care units.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Sepsis, pneumonia, trauma, aspiration, near-drowning, inhalation injuries, and multiple blood transfusions.
Prognosis:
The expected outcome or course of the condition over time.
Prognosis can vary, with mortality rates ranging from 30-40%. Survivors may have long-term lung function impairment.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Barotrauma, ventilator-associated pneumonia, pneumothorax, and long-term respiratory complications.
Hypercapnic Respiratory Failure
Specialty: Pulmonology
Category: Respiratory Failure and Critical Care
Symptoms:
shortness of breath; confusion; headache; drowsiness; flushed skin; rapid breathing
Root Cause:
Hypercapnic respiratory failure occurs when the lungs are unable to remove enough carbon dioxide from the blood, often due to obstructive lung diseases such as COPD or severe asthma.
How it's Diagnosed: videos
Diagnosis is confirmed through ABG analysis showing elevated levels of carbon dioxide (PaCO2 > 45 mmHg), along with clinical symptoms of hypoventilation.
Treatment:
Management includes non-invasive positive pressure ventilation (NIPPV) or invasive mechanical ventilation, bronchodilators, corticosteroids, and addressing the underlying cause (e.g., COPD exacerbation).
Medications:
Bronchodilators (e.g., albuterol , ipratropium ) to open the airways, corticosteroids (e.g., methylprednisolone ), and respiratory stimulants (e.g., theophylline ) are commonly used. These medications are classified as bronchodilators, corticosteroids, and respiratory stimulants.
Prevalence:
How common the health condition is within a specific population.
Common among patients with chronic obstructive pulmonary disease (COPD), emphysema, and severe asthma.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Chronic obstructive pulmonary disease (COPD), obesity, neuromuscular disorders, severe asthma, and drug overdose.
Prognosis:
The expected outcome or course of the condition over time.
Prognosis depends on the underlying condition; with appropriate treatment, many patients can recover, although severe cases may have poor outcomes.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Respiratory acidosis, pulmonary hypertension, organ failure, and long-term respiratory impairment.
Hypoxemic Respiratory Failure
Specialty: Pulmonology
Category: Respiratory Failure and Critical Care
Symptoms:
severe shortness of breath; cyanosis; confusion; tachypnea; increased heart rate; restlessness
Root Cause:
Hypoxemic respiratory failure is characterized by low oxygen levels in the blood despite adequate ventilation, often due to diseases affecting gas exchange like pneumonia, pulmonary edema, or pulmonary embolism.
How it's Diagnosed: videos
Diagnosis is made through ABG analysis showing low oxygen levels (PaO2 < 60 mmHg) and normal or low carbon dioxide levels, along with clinical signs of hypoxia.
Treatment:
Treatment involves supplemental oxygen therapy, mechanical ventilation if necessary, and addressing the underlying cause (e.g., antibiotics for infection, diuretics for pulmonary edema).
Medications:
Medications can include antibiotics (e.g., ceftriaxone , azithromycin for pneumonia), diuretics (e.g., furosemide for pulmonary edema), and corticosteroids (e.g., dexamethasone ). These medications are classified as antibiotics, diuretics, and corticosteroids.
Prevalence:
How common the health condition is within a specific population.
Common in patients with pneumonia, pulmonary embolism, and acute respiratory distress syndrome.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Pulmonary infections, trauma, aspiration, acute lung injury, and heart failure.
Prognosis:
The expected outcome or course of the condition over time.
Prognosis depends on the underlying cause; with prompt treatment, many patients recover, but severe cases can result in death or long-term complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Organ failure, cardiac arrhythmias, brain damage due to prolonged hypoxia, and pulmonary fibrosis in severe cases.
Hypertensive Crisis
Specialty: Cardiovascular
Category: Vascular Diseases
Sub-category: Hypertension (High Blood Pressure)
Symptoms:
severe headache; blurred vision; shortness of breath; chest pain; confusion; nausea/vomiting; nosebleeds
Root Cause:
Sudden, severe elevation of blood pressure (≥180/120 mmHg) with or without acute organ damage. Hypertensive emergency involves organ damage, while urgency does not.
How it's Diagnosed: videos
Blood pressure measurement; assessment for end-organ damage (e.g., labs for kidney function, EKG, imaging for stroke or heart damage)
Treatment:
Immediate reduction of blood pressure in a controlled manner to prevent or minimize organ damage. In emergencies, intravenous medications are used.
Medications:
For hypertensive emergencies, IV medications such as nitroprusside (vasodilator), labetalol (beta-blocker), or nicardipine (calcium channel blocker). For urgency, oral medications like captopril (ACE inhibitor) or clonidine (alpha agonist) are used.
Prevalence:
How common the health condition is within a specific population.
Relatively rare, but more common in patients with poorly controlled hypertension or non-adherence to treatment.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Uncontrolled hypertension; kidney disease; pheochromocytoma; pregnancy-related hypertension (e.g., preeclampsia); sudden discontinuation of antihypertensive medications
Prognosis:
The expected outcome or course of the condition over time.
With prompt treatment, prognosis is good; delayed treatment can lead to permanent organ damage or death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Stroke; heart attack; acute kidney injury; pulmonary edema; aortic dissection
Hyperosmolar Hyperglycemic State (HHS)
Specialty: Diabetes and Endocrinology
Category: Diabetes Mellitus and Related Disorders
Sub-category: Acute Complications
Symptoms:
extreme thirst; frequent urination; dry mouth; weakness; confusion; seizures; coma
Root Cause:
Severe hyperglycemia leads to osmotic diuresis and dehydration without significant ketone production.
How it's Diagnosed: videos
Blood tests showing extremely high blood glucose (>600 mg/dL), high plasma osmolality, and absence or low levels of ketones.
Treatment:
Intravenous fluids, insulin therapy, and electrolyte replacement.
Medications:
Regular insulin administered intravenously to control blood glucose levels.
Prevalence:
How common the health condition is within a specific population.
Rare; primarily occurs in elderly individuals with type 2 diabetes.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Dehydration, infections, poorly controlled diabetes, or medications (e.g., steroids).
Prognosis:
The expected outcome or course of the condition over time.
High mortality rate if untreated; early intervention improves outcomes.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Severe dehydration, shock, thromboembolism, and death.
Hypoglycemia (due to diabetes management)
Specialty: Diabetes and Endocrinology
Category: Diabetes Mellitus and Related Disorders
Sub-category: Acute Complications
Symptoms:
sweating; shakiness; dizziness; hunger; confusion; irritability; seizures; loss of consciousness
Root Cause:
Excess insulin or glucose-lowering medications reduce blood sugar levels below normal (<70 mg/dL).
How it's Diagnosed: videos
Blood glucose measurement; symptoms resolve with glucose administration.
Treatment:
Immediate consumption of fast-acting carbohydrates (e.g., glucose tablets, fruit juice); glucagon injection for severe cases.
Medications:
Glucagon injection or glucose gel for emergency treatment of severe hypoglycemia.
Prevalence:
How common the health condition is within a specific population.
Common in individuals on insulin or sulfonylureas; varies by treatment regimen.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Excess insulin, skipping meals, intense physical activity, or alcohol consumption.
Prognosis:
The expected outcome or course of the condition over time.
Good with prompt treatment; repeated episodes can impair awareness and cognitive function.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Seizures, coma, accidents, and death.
Thyroid Storm (Thyrotoxic Crisis)
Specialty: Diabetes and Endocrinology
Category: Thyroid Disorders
Sub-category: Other Thyroid Disorders
Symptoms:
high fever; rapid heart rate (tachycardia); nervousness or anxiety; tremors; confusion; diarrhea; vomiting; extreme fatigue; shortness of breath
Root Cause:
Severe, life-threatening exacerbation of hyperthyroidism, often triggered by infection, surgery, trauma, or untreated Graves' disease.
How it's Diagnosed: videos
Clinical presentation (severe hyperthyroid symptoms), lab tests showing suppressed TSH and elevated T3/T4 levels, alongside exclusion of other conditions (e.g., sepsis).
Treatment:
Immediate hospitalization, beta-blockers (e.g., propranolol) for symptom control, antithyroid medications (e.g., methimazole or propylthiouracil), iodine to inhibit thyroid hormone release, and corticosteroids to reduce inflammation.
Medications:
Methimazole or propylthiouracil (antithyroid drugs); propranolol (beta-blocker); potassium iodide (iodine preparation ); hydrocortisone (corticosteroid).
Prevalence:
How common the health condition is within a specific population.
Rare, occurring in approximately 1–2% of patients with untreated or poorly managed hyperthyroidism.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Untreated hyperthyroidism, Graves' disease, recent surgery, infection, pregnancy, or iodine exposure.
Prognosis:
The expected outcome or course of the condition over time.
High mortality if untreated (up to 30%); prognosis improves significantly with prompt treatment.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Heart failure, arrhythmias, multiple organ failure, death.
Primary Hyperparathyroidism (e.g., Parathyroid Adenoma)
Specialty: Diabetes and Endocrinology
Category: Parathyroid Disorders
Sub-category: Hyperparathyroidism
Symptoms:
fatigue; muscle weakness; bone pain; nausea; kidney stones; constipation; polyuria; depression; confusion
Root Cause:
Overproduction of parathyroid hormone (PTH) caused by a benign tumor (adenoma) in one or more parathyroid glands, leading to elevated calcium levels.
How it's Diagnosed: videos
Blood tests (elevated calcium and PTH levels), 24-hour urine calcium test, imaging studies like ultrasound or Sestamibi scan for adenoma localization.
Treatment:
Surgical removal of the adenoma (parathyroidectomy); non-surgical management includes hydration and medications to control calcium levels.
Medications:
Calcimimetics (e.g., cinacalcet , which decreases PTH secretion), bisphosphonates (e.g., alendronate , to reduce bone resorption), and vitamin D supplements if indicated.
Prevalence:
How common the health condition is within a specific population.
Affects approximately 1–3 per 1,000 individuals, with a higher prevalence in postmenopausal women.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Female sex, age over 50, genetic predisposition, prolonged lithium or radiation exposure.
Prognosis:
The expected outcome or course of the condition over time.
Excellent prognosis with surgery; most symptoms resolve after treatment, though bone density recovery may take time.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Osteoporosis, kidney stones, chronic kidney disease, cardiovascular issues due to hypercalcemia.
Phosphate Disorders
Specialty: Diabetes and Endocrinology
Category: Bone and Mineral Metabolism Disorders
Sub-category: Electrolyte Imbalance
Symptoms:
muscle weakness; bone pain; fatigue; confusion; seizures; irregular heartbeats
Root Cause:
Abnormal phosphate levels in the blood, either hypophosphatemia (low phosphate) or hyperphosphatemia (high phosphate), affecting cellular and skeletal functions.
How it's Diagnosed: videos
Blood tests to measure serum phosphate, calcium, and PTH levels; urine tests for phosphate excretion; assessment of vitamin D status and kidney function.
Treatment:
Treated by addressing the underlying cause, with hypophosphatemia managed using oral or intravenous phosphate supplementation, and hyperphosphatemia treated with phosphate binders, dietary restrictions, and managing associated conditions like kidney disease.
Medications:
Hypophosphatemia - Oral phosphate supplements (e.g., potassium phosphate or sodium phosphate) or intravenous phosphate for severe cases. Hyperphosphatemia - Managed with phosphate binders such as calcium acetate, calcium carbonate, sevelamer , lanthanum carbonate, or aluminum hydroxide, often alongside dietary phosphate restrictions and treatments for underlying conditions like chronic kidney disease.
Prevalence:
How common the health condition is within a specific population.
Varies widely; hypophosphatemia is common in hospitalized patients and those with malnutrition, while hyperphosphatemia often occurs in individuals with chronic kidney disease (CKD).
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Kidney disease, malnutrition, alcohol dependency, vitamin D deficiency or excess, certain medications (e.g., diuretics or antacids).
Prognosis:
The expected outcome or course of the condition over time.
Good with early recognition and management. Chronic untreated phosphate disorders can lead to long-term complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
For hypophosphatemia
Hypophosphatemia
Specialty: Diabetes and Endocrinology
Category: Bone and Mineral Metabolism Disorders
Symptoms:
muscle weakness; bone pain; rhabdomyolysis; confusion; seizures
Root Cause:
Deficiency of phosphate in the blood due to inadequate intake, excessive loss, or intracellular shifts (e.g., refeeding syndrome).
How it's Diagnosed: videos
Serum phosphate levels <2.5 mg/dL, alongside clinical evaluation and identifying underlying causes.
Treatment:
Oral or intravenous phosphate supplementation depending on severity, and addressing the underlying cause (e.g., vitamin D deficiency or refeeding syndrome).
Medications:
Oral phosphate supplements (e.g., sodium phosphate, potassium phosphate) or intravenous phosphate in severe cases. Vitamin D (calcitriol ) may also be used to aid phosphate absorption.
Prevalence:
How common the health condition is within a specific population.
Common in critically ill patients, alcoholics, or those with refeeding syndrome; prevalence varies depending on underlying conditions.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Chronic alcoholism, malnutrition, vitamin D deficiency, refeeding syndrome, and hyperparathyroidism.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with prompt treatment; prolonged or severe cases can result in complications like muscle breakdown or cardiac issues.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Rhabdomyolysis, respiratory failure, hemolysis, and impaired immune function.
Hypomagnesemia
Specialty: Nephrology
Category: Electrolyte and Acid-Base Disorders
Symptoms:
muscle cramps; tremors; weakness; fatigue; nausea; vomiting; irritability; confusion; seizures; cardiac arrhythmias (e.g., prolonged qt interval)
Root Cause:
Low magnesium levels in the blood due to inadequate dietary intake, increased excretion via kidneys or gastrointestinal tract, or certain medications.
How it's Diagnosed: videos
Blood tests measuring serum magnesium levels; additional evaluations may include kidney function tests and assessment of other electrolytes (e.g., calcium and potassium).
Treatment:
Address underlying causes, magnesium supplementation (oral or intravenous), and correction of associated electrolyte imbalances.
Medications:
Magnesium supplements, such as magnesium oxide (oral) or magnesium sulfate (IV for severe cases). These are electrolyte supplements.
Prevalence:
How common the health condition is within a specific population.
Common in hospitalized patients (up to 10%–20%) and in individuals with chronic illnesses.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Chronic alcoholism, malnutrition, gastrointestinal disorders (e.g., Crohn’s disease), diuretics, proton pump inhibitors, and diabetes.
Prognosis:
The expected outcome or course of the condition over time.
Generally good with timely diagnosis and treatment, but prolonged or severe cases can lead to significant complications if untreated.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Cardiac arrhythmias, seizures, muscle paralysis, and refractory hypocalcemia or hypokalemia.
Reactive Hypoglycemia
Specialty: Diabetes and Endocrinology
Category: Pancreatic Endocrine Disorders
Sub-category: Hypoglycemia (Non-Diabetes Related)
Symptoms:
shakiness; sweating; palpitations; hunger; anxiety; confusion; drowsiness; fatigue
Root Cause:
Excessive insulin release following a meal, leading to a drop in blood glucose levels within a few hours after eating.
How it's Diagnosed: videos
Based on symptoms occurring 2-4 hours post-meal and resolved with carbohydrate intake. Mixed meal tolerance test (MMTT) or continuous glucose monitoring (CGM) may confirm diagnosis.
Treatment:
Dietary modifications, including frequent small meals, low glycemic index foods, and balanced macronutrient intake. In rare severe cases, medications may be used.
Medications:
Acarbose (alpha-glucosidase inhibitor to slow carbohydrate absorption) and in experimental settings, diazoxide to reduce insulin secretion.
Prevalence:
How common the health condition is within a specific population.
Common but underdiagnosed; exact prevalence unknown as many cases are self-limited and not reported.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
History of gastric surgery (e.g., Roux-en-Y gastric bypass), prediabetes, or other conditions affecting glucose metabolism.
Prognosis:
The expected outcome or course of the condition over time.
Typically manageable with dietary adjustments; long-term outcomes are excellent in most cases.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
If untreated, frequent hypoglycemia can lead to weight gain due to compensatory eating and impact quality of life.
Hyperinsulinism
Specialty: Diabetes and Endocrinology
Category: Pancreatic Endocrine Disorders
Symptoms:
hypoglycemia (low blood sugar); dizziness; sweating; shaking; confusion; blurred vision; seizures; loss of consciousness
Root Cause:
Excessive secretion of insulin from the pancreas, often due to a tumor (insulinoma), genetic mutations affecting insulin regulation, or overcompensation for insulin resistance.
How it's Diagnosed: videos
Blood tests (glucose, insulin, and C-peptide levels during hypoglycemia), fasting tests, imaging studies (CT, MRI, or PET scans), and genetic testing in congenital cases.
Treatment:
Dietary management, surgery (if caused by an insulinoma), or medications to regulate insulin secretion.
Medications:
Diazoxide (a potassium channel opener that inhibits insulin secretion) or octreotide (a somatostatin analog to suppress insulin release).
Prevalence:
How common the health condition is within a specific population.
Rare; congenital forms are more common in neonates, while insulinomas occur in about 1-4 per million people annually.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Family history of congenital hyperinsulinism, genetic mutations, or conditions like MEN1 syndrome.
Prognosis:
The expected outcome or course of the condition over time.
Depends on the cause; manageable with treatment but severe hypoglycemia can lead to long-term complications if not addressed.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Recurrent hypoglycemia leading to seizures, brain damage, or developmental delays (in infants).
Hepatic Encephalopathy
Specialty: Gastrointestinal
Category: Liver Disorders
Sub-category: Neurological Manifestations of Liver Disease
Symptoms:
confusion; difficulty concentrating; personality changes; disorientation; sleep disturbances; tremors (asterixis); slurred speech; lethargy; in severe cases, coma
Root Cause:
Build-up of toxins like ammonia in the bloodstream due to the liver's inability to properly detoxify them, often secondary to liver dysfunction or portal-systemic shunting.
How it's Diagnosed: videos
Clinical assessment, blood tests (elevated ammonia levels), liver function tests, and imaging studies to rule out other causes of altered mental status.
Treatment:
Reducing ammonia production and absorption using dietary protein restriction, lactulose (to acidify the colon and reduce ammonia absorption), and antibiotics like rifaximin (to reduce ammonia-producing gut bacteria).
Medications:
Lactulose (a non-absorbable sugar that traps ammonia in the colon), rifaximin (a gut-specific antibiotic), and sometimes neomycin or metronidazole (alternative antibiotics for reducing ammonia production).
Prevalence:
How common the health condition is within a specific population.
Common among individuals with advanced liver disease, with approximately 30-45% of cirrhotic patients developing some form of hepatic encephalopathy.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Advanced liver disease, cirrhosis, portal hypertension, gastrointestinal bleeding, infections, dehydration, electrolyte imbalances, and high-protein diets.
Prognosis:
The expected outcome or course of the condition over time.
Reversible with treatment in early stages, but recurrent episodes are common unless the underlying liver dysfunction is addressed. Severe or untreated cases may lead to permanent brain damage or death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Recurrent episodes, progressive cognitive impairment, reduced quality of life, coma, and increased mortality.
Alzheimer’s Disease
Specialty: Neurology
Category: Neurodegenerative Disorders
Symptoms:
memory loss; confusion; difficulty planning or solving problems; changes in mood or personality; difficulty completing familiar tasks; language problems; disorientation; loss of initiative; poor judgment
Root Cause:
Progressive accumulation of amyloid-beta plaques and tau tangles in the brain, leading to neuronal degeneration and loss of synaptic connections.
How it's Diagnosed: videos
Diagnosed via cognitive testing and brain imaging.
Treatment:
Treated with cholinesterase inhibitors (e.g., donepezil) and NMDA receptor antagonists (e.g., memantine).
Medications:
Cholinesterase inhibitors (e.g., Donepezil , Rivastigmine , Galantamine ) to improve communication between nerve cells. NMDA receptor antagonist (e.g., Memantine ) to regulate glutamate and prevent neuronal damage. Newer drugs, such as Leqembi (lecanemab ), which targets amyloid plaques.
Prevalence:
How common the health condition is within a specific population.
Affects approximately 6 million people in the United States; globally, over 50 million people are living with dementia, with Alzheimer’s accounting for 60–80% of cases.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Advanced age, genetic predisposition (e.g., APOE-e4 allele), family history, cardiovascular conditions (hypertension, diabetes, hyperlipidemia), head trauma, lower education levels, and lifestyle factors (e.g., sedentary lifestyle).
Prognosis:
The expected outcome or course of the condition over time.
Progressive and incurable; life expectancy varies from 3–20 years post-diagnosis, with an average of 8–10 years.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Severe cognitive decline, inability to perform daily tasks, increased risk of infections (e.g., pneumonia), malnutrition, falls, and complete dependency on caregivers.
Acute Disseminated Encephalomyelitis (ADEM)
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
fever; headache; nausea; vomiting; confusion; seizures; motor weakness; vision problems; lethargy
Root Cause:
An autoimmune response often triggered by an infection or, less commonly, vaccination, causing inflammation and demyelination in the brain and spinal cord.
How it's Diagnosed: videos
Clinical evaluation, MRI of the brain (showing diffuse demyelination), lumbar puncture (to analyze cerebrospinal fluid), and exclusion of other conditions like multiple sclerosis.
Treatment:
High-dose corticosteroids (e.g., methylprednisolone), plasma exchange (plasmapheresis), intravenous immunoglobulin (IVIG), and supportive care.
Medications:
Corticosteroids (e.g., methylprednisolone for reducing inflammation), IVIG (immunomodulatory therapy), or plasmapheresis (used when steroids are insufficient). Corticosteroids are classified as anti-inflammatory agents.
Prevalence:
How common the health condition is within a specific population.
Rare; estimated annual incidence is 0.4-0.8 per 100,000 people, more common in children than adults.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Recent viral or bacterial infections, recent vaccination, genetic predisposition, or underlying autoimmune disorders.
Prognosis:
The expected outcome or course of the condition over time.
Good in most cases; symptoms often resolve with treatment, although some individuals may experience residual neurological deficits.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Long-term neurological impairment, recurrence (though rare), or progression to conditions like multiple sclerosis in some cases.
Encephalitis (e.g., Herpes Simplex Encephalitis)
Specialty: Neurology
Category: Infections and Inflammatory Diseases
Symptoms:
fever; headache; altered mental status; seizures; focal neurological deficits; confusion; memory loss; personality changes
Root Cause:
Inflammation of the brain, often caused by viral infections (e.g., herpes simplex virus, arboviruses) or autoimmune mechanisms.
How it's Diagnosed: videos
MRI to detect brain inflammation; lumbar puncture for CSF analysis and PCR for viral DNA (e.g., HSV); EEG to evaluate for seizures; blood tests for autoimmune markers if suspected.
Treatment:
Depends on cause. Antiviral therapy for HSV (e.g., acyclovir), supportive care for arboviruses, and immunosuppressive treatment (e.g., corticosteroids, IVIG) for autoimmune causes.
Medications:
For HSV encephalitis - Acyclovir (antiviral agent). For autoimmune encephalitis - Corticosteroids, IVIG, plasmapheresis, or rituximab (a monoclonal antibody).
Prevalence:
How common the health condition is within a specific population.
Herpes simplex encephalitis occurs in approximately 1 in 250,000 to 500,000 people annually. Prevalence varies for other causes.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Immunocompromised state, travel to areas with endemic arboviruses, exposure to infected individuals, autoimmune diseases.
Prognosis:
The expected outcome or course of the condition over time.
Early treatment (especially for HSV) significantly improves outcomes. Delayed treatment can lead to permanent neurological damage or death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Long-term neurological deficits (e.g., memory impairment, seizures, cognitive dysfunction), coma, death (if untreated).
Autoimmune Encephalitis
Specialty: Neurology
Category: Infections and Inflammatory Diseases
Symptoms:
memory loss; behavioral changes; seizures; confusion; psychosis; autonomic dysfunction; movement disorders
Root Cause:
Inflammation of the brain caused by an autoimmune response, often triggered by antibodies targeting neuronal receptors or intracellular proteins.
How it's Diagnosed: videos
Antibody testing in blood and CSF (e.g., anti-NMDA, anti-LGI1), MRI (inflammatory changes), EEG (abnormal activity), and clinical evaluation.
Treatment:
Immunosuppressive therapies, such as corticosteroids, IVIG, plasmapheresis, or rituximab.
Medications:
First-line - Corticosteroids (e.g., methylprednisolone ), IVIG, plasmapheresis. Second-line - Rituximab (monoclonal antibody), cyclophosphamide (chemotherapy agent with immunosuppressive properties).
Prevalence:
How common the health condition is within a specific population.
Rare, exact prevalence unknown, but cases have been increasing due to improved diagnostic capabilities.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Paraneoplastic syndromes (e.g., tumors producing antibodies), viral infections, genetic predisposition.
Prognosis:
The expected outcome or course of the condition over time.
Good with early diagnosis and treatment; delays can lead to significant disability or death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Long-term cognitive impairment, epilepsy, autonomic instability, death in severe cases.
Anti-LGI1 Encephalitis
Specialty: Neurology
Category: Infections and Inflammatory Diseases
Symptoms:
memory impairment; seizures (commonly faciobrachial dystonic seizures); confusion; behavioral changes; hyponatremia (low sodium levels)
Root Cause:
Autoimmune encephalitis caused by antibodies targeting the leucine-rich glioma-inactivated protein 1 (LGI1), which is involved in synaptic function.
How it's Diagnosed: videos
Detection of anti-LGI1 antibodies in blood or CSF, MRI showing medial temporal lobe abnormalities, and clinical presentation (e.g., specific seizure types).
Treatment:
Immunotherapy, including corticosteroids, IVIG, plasmapheresis, and long-term immunosuppressive drugs if needed.
Medications:
First-line - Corticosteroids (e.g., prednisone or methylprednisolone ), IVIG, plasmapheresis. Second-line - Rituximab or azathioprine for refractory or recurrent cases. Antiepileptic drugs (e.g., levetiracetam or lacosamide ) for seizure control.
Prevalence:
How common the health condition is within a specific population.
Rare; primarily affects middle-aged to older adults.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
No well-defined risk factors, though associations with autoimmune predispositions or malignancies have been noted.
Prognosis:
The expected outcome or course of the condition over time.
Generally good with early treatment, but delays may lead to cognitive deficits or chronic epilepsy.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Persistent memory impairment, chronic epilepsy, hyponatremia-related complications, and rarely death if untreated.
Concussion
Specialty: Neurology
Category: Traumatic Brain and Spinal Cord Injuries
Symptoms:
headache; confusion; dizziness; nausea; vomiting; blurred vision; sensitivity to light and noise; memory loss; difficulty concentrating; fatigue
Root Cause:
A mild traumatic brain injury caused by a sudden impact or jolt to the head, leading to temporary disruption of brain function.
How it's Diagnosed: videos
Clinical evaluation (patient history, symptom analysis, and physical examination), neurocognitive testing, imaging tests like CT or MRI (if severe symptoms or risk of complications).
Treatment:
Rest, gradual return to activities, symptom management, cognitive and physical rehabilitation if needed.
Medications:
Pain relievers like acetaminophen or ibuprofen for headaches. Prescription medications, such as amitriptyline (tricyclic antidepressant) or topiramate (antiepileptic), may be used for post-concussion headaches or migraines.
Prevalence:
How common the health condition is within a specific population.
Common; estimated 1.6–3.8 million concussions occur annually in the U.S. related to sports and recreational activities.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Participation in contact sports, history of previous concussions, motor vehicle accidents, falls, younger age (children and adolescents).
Prognosis:
The expected outcome or course of the condition over time.
Generally good, with most people recovering fully within weeks to months; symptoms may persist longer in post-concussion syndrome.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Post-concussion syndrome, second impact syndrome, chronic traumatic encephalopathy (CTE), persistent cognitive or emotional problems.
Traumatic Brain Injury (TBI)
Specialty: Neurology
Category: Traumatic Brain and Spinal Cord Injuries
Symptoms:
loss of consciousness; headache; confusion; memory loss; dizziness; vomiting; seizures; speech difficulties; weakness or numbness; changes in behavior
Root Cause:
Brain damage caused by external force, such as a blow to the head, penetration by an object, or violent shaking.
How it's Diagnosed: videos
Physical and neurological examinations, imaging tests like CT scans or MRIs, Glasgow Coma Scale assessment.
Treatment:
Emergency stabilization, surgical intervention if necessary (to relieve pressure or repair damage), physical and cognitive rehabilitation, supportive care.
Medications:
Diuretics (e.g., mannitol ) to reduce brain swelling; anticonvulsants (e.g., levetiracetam ) to prevent seizures; sedatives (e.g., propofol ) for agitation or to manage intracranial pressure.
Prevalence:
How common the health condition is within a specific population.
About 2.8 million emergency department visits for TBI in the U.S. annually; common in all age groups, particularly young adults and the elderly.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Falls, vehicle accidents, sports injuries, physical violence, military combat exposure.
Prognosis:
The expected outcome or course of the condition over time.
Varies widely; mild TBIs often resolve fully, while severe TBIs may result in long-term disabilities or death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Seizures, infections, hydrocephalus, cognitive or emotional impairments, death.
Subdural Hematoma
Specialty: Neurology
Category: Traumatic Brain and Spinal Cord Injuries
Symptoms:
headache; confusion; drowsiness; vomiting; seizures; weakness; slurred speech; loss of consciousness
Root Cause:
Bleeding between the dura mater and the arachnoid membrane, typically caused by trauma to the head.
How it's Diagnosed: videos
Diagnosed through neuroimaging, primarily CT scans or MRI, to detect blood accumulation.
Treatment:
Treatment ranges from observation for mild cases to surgical intervention (craniotomy or burr hole drainage) for severe cases.
Medications:
Antiepileptic drugs (AEDs) such as levetiracetam or phenytoin may be prescribed to prevent seizures. Pain management medications like acetaminophen are also used.
Prevalence:
How common the health condition is within a specific population.
Subdural hematomas are relatively common, especially among older adults and individuals on anticoagulant therapy.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Head trauma, older age, use of blood thinners, alcohol abuse, and brain atrophy.
Prognosis:
The expected outcome or course of the condition over time.
Variable depending on severity and treatment; mild cases have a good prognosis, but severe cases can lead to permanent neurological impairment or death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Increased intracranial pressure, brain herniation, chronic subdural hematoma, seizures, and cognitive deficits.
Epidural Hematoma
Specialty: Neurology
Category: Traumatic Brain and Spinal Cord Injuries
Symptoms:
brief loss of consciousness followed by a lucid interval; headache; vomiting; confusion; weakness; seizures; unequal pupil size; progressive loss of consciousness
Root Cause:
Accumulation of blood between the skull and dura mater, often due to the rupture of an artery, commonly the middle meningeal artery, from trauma.
How it's Diagnosed: videos
Diagnosed through CT scans or MRI to visualize blood collection.
Treatment:
Emergency surgical evacuation of the hematoma via craniotomy or burr hole surgery.
Medications:
Anticonvulsants like levetiracetam to prevent seizures and analgesics for pain management.
Prevalence:
How common the health condition is within a specific population.
Less common than subdural hematomas but more frequently observed in younger patients with head trauma.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Skull fractures, head trauma, high-impact injuries, and anticoagulant therapy.
Prognosis:
The expected outcome or course of the condition over time.
Good if treated promptly; untreated cases can lead to brain herniation and death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Increased intracranial pressure, brain herniation, permanent neurological deficits, and death if untreated.
Delirium
Specialty: Mental Health and Psychology
Category: Emergency
Sub-category: Cognitive Disorders
Symptoms:
confusion; disorientation; hallucinations; restlessness; fluctuating levels of consciousness; impaired attention
Root Cause:
Acute disturbance in brain function, often caused by an underlying medical condition, medication, or substance withdrawal.
How it's Diagnosed: videos
Clinical evaluation, including history, physical examination, and laboratory tests to identify contributing factors. Use of diagnostic tools like the Confusion Assessment Method (CAM).
Treatment:
Treating the underlying cause (e.g., infection, electrolyte imbalance); supportive care to ensure safety and minimize distress.
Medications:
Antipsychotics like haloperidol or quetiapine for severe agitation; benzodiazepines for delirium caused by alcohol withdrawal.
Prevalence:
How common the health condition is within a specific population.
Common in hospitalized patients, especially older adults; occurs in up to 50% of elderly individuals post-surgery.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Advanced age, pre-existing cognitive impairment, severe illness, substance abuse, or multiple medications.
Prognosis:
The expected outcome or course of the condition over time.
Reversible with prompt treatment of the underlying cause; delayed treatment may result in prolonged symptoms or complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Long-term cognitive decline, increased risk of institutionalization, and higher mortality rates in severe cases.
Acute Kidney Injury (in elderly patients)
Specialty: Senior Health and Geriatrics
Category: Urologic and Renal Disorders
Symptoms:
decreased urine output; swelling in legs or ankles; fatigue; shortness of breath; confusion; nausea and vomiting; severe fatigue or weakness
Root Cause:
Acute kidney injury (AKI) in elderly patients is typically caused by factors such as dehydration, medication toxicity, infections, or obstruction of the urinary tract. The kidneys suddenly lose their ability to filter waste from the blood.
How it's Diagnosed: videos
AKI is diagnosed through blood tests (elevated creatinine levels and BUN), urine tests (urinalysis for protein, blood, and other abnormalities), and imaging studies (ultrasound to assess for obstructions). In some cases, kidney biopsy may be performed.
Treatment:
Treatment includes identifying and addressing the underlying cause (e.g., rehydration, stopping harmful medications, treating infections), medications to support kidney function, and possibly dialysis if kidney function does not recover.
Medications:
Medications may include diuretics to manage fluid overload, vasopressors for blood pressure support, and antibiotics if an infection is present. In cases of electrolyte imbalances, medications like potassium binders or phosphate binders may be required.
Prevalence:
How common the health condition is within a specific population.
AKI is common in elderly patients, particularly those who are hospitalized or have multiple comorbid conditions. The incidence increases with age, affecting up to 20-30% of hospitalized elderly individuals.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Age, dehydration, underlying chronic kidney disease, cardiovascular disease, use of nephrotoxic medications (e.g., NSAIDs, ACE inhibitors), infections, and surgery.
Prognosis:
The expected outcome or course of the condition over time.
The prognosis for AKI depends on the underlying cause, the extent of kidney damage, and the patient's overall health. Some elderly patients recover full kidney function, while others may develop chronic kidney disease or experience long-term kidney dysfunction.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Complications include electrolyte imbalances, fluid overload, infections, and progression to chronic kidney disease or end-stage renal disease if not managed promptly.
Traumatic brain injury (TBI) from falls
Specialty: Senior Health and Geriatrics
Category: Falls, Mobility, and Frailty
Sub-category: Falls and Injuries
Symptoms:
headache; dizziness; nausea or vomiting; loss of consciousness; confusion; memory problems; difficulty concentrating; changes in mood or personality
Root Cause:
Injury to the brain caused by a blow or jolt to the head, often from falls, which may result in contusions, concussions, or more severe brain damage.
How it's Diagnosed: videos
Diagnosis is based on clinical symptoms, physical examination, and imaging studies such as CT scans or MRIs to detect brain injury.
Treatment:
Treatment varies based on the severity of the injury, ranging from observation and rest to surgical intervention for severe brain injury.
Medications:
Medications for TBI may include pain relievers (acetaminophen or ibuprofen ), anticonvulsants if seizures are present, and antidepressants if mood disorders develop. Antiemetics (e.g., ondansetron ) may be used for nausea.
Prevalence:
How common the health condition is within a specific population.
TBI is a leading cause of injury-related morbidity in older adults, especially those with balance issues or frailty.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Age (especially over 65), previous history of TBI, frailty, falls, anticoagulant use, and environmental hazards.
Prognosis:
The expected outcome or course of the condition over time.
Recovery from TBI can range from full recovery to long-term cognitive and physical impairments, depending on the severity of the injury. Older adults often have a slower recovery process.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Long-term complications can include cognitive impairment, memory loss, post-concussion syndrome, and an increased risk of dementia or other neurological disorders. There may also be an increased risk of recurrent falls.
Polypharmacy and Drug Interactions
Specialty: Senior Health and Geriatrics
Category: Geriatric Syndromes
Symptoms:
adverse drug reactions; increased falls risk; confusion; dizziness; fatigue; gastrointestinal issues; orthostatic hypotension
Root Cause:
Polypharmacy occurs when a patient uses multiple medications, often more than necessary. Drug interactions can lead to adverse effects or reduced drug efficacy, especially in older adults with multiple chronic conditions.
How it's Diagnosed: videos
Diagnosis is based on a detailed medication history, identifying all prescribed medications, over-the-counter drugs, supplements, and herbal remedies. Assessment may include reviewing drug interaction databases and conducting lab tests to monitor potential adverse effects.
Treatment:
Treatment involves careful medication review, discontinuation of unnecessary drugs, substitution of drugs with safer alternatives, and monitoring of ongoing therapy. Coordination among healthcare providers (e.g., primary care physicians, specialists, pharmacists) is essential.
Medications:
In polypharmacy, medication adjustments are often necessary. There are no specific "treatment medications" per se, but medications may be adjusted or stopped based on interactions. Some examples include discontinuing sedatives or pain relievers like benzodiazepines, opioids, or NSAIDs, as they may interact poorly with other drugs. Medication adjustments typically involve switching to medications with fewer interactions or using smaller dosages.
Prevalence:
How common the health condition is within a specific population.
Polypharmacy is common in older adults, with estimates ranging from 25% to 50% of elderly people taking five or more medications concurrently. The prevalence increases with age and the number of chronic conditions.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Advanced age, multiple chronic health conditions, multiple healthcare providers, self-medication with over-the-counter drugs or supplements, and lack of coordination in care.
Prognosis:
The expected outcome or course of the condition over time.
If properly managed, the risks associated with polypharmacy and drug interactions can be minimized. Regular reviews and adjustments of medications can help prevent complications and improve outcomes.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Increased risk of adverse drug reactions, hospitalizations due to drug interactions, falls, cognitive decline, and decreased quality of life.
Hypovolemic shock
Specialty: Trauma and Injuries
Category: Other Trauma-Related Conditions
Sub-category: Complications of Trauma
Symptoms:
rapid heart rate; low blood pressure; weak pulse; pale, cool, clammy skin; rapid, shallow breathing; dizziness; confusion; thirst
Root Cause:
A significant loss of blood or body fluids leading to inadequate blood volume, causing insufficient oxygen and nutrient delivery to tissues and organs.
How it's Diagnosed: videos
Diagnosis is based on clinical signs, symptoms, and a history of trauma or fluid loss. It is confirmed by blood tests (e.g., hemoglobin levels, electrolytes) and physical exams. Imaging may be used to identify the source of fluid loss.
Treatment:
The primary treatment is to restore blood volume through intravenous fluids (normal saline or lactated Ringer's solution) and blood transfusions if necessary. Identifying and treating the underlying cause of fluid loss is crucial.
Medications:
Medications may include vasopressors (e.g., norepinephrine , phenylephrine ) to raise blood pressure and antibiotics if infection is the cause. Vasopressors are sympathomimetic drugs that increase vascular tone and blood pressure.
Prevalence:
How common the health condition is within a specific population.
It is a medical emergency that can occur in any age group. The exact prevalence varies based on the population and the underlying causes, but it is commonly seen in trauma patients.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Major trauma (e.g., accidents, burns), gastrointestinal bleeding, surgery, dehydration, severe burns, and certain medical conditions like aneurysms or ruptured organs.
Prognosis:
The expected outcome or course of the condition over time.
Prognosis depends on the cause, timing of treatment, and overall health of the patient. Early intervention with fluid resuscitation significantly improves outcomes.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Organ failure (kidneys, liver), electrolyte imbalances, acidosis, and, if untreated, death due to shock.
Septic shock
Specialty: Trauma and Injuries
Category: Other Trauma-Related Conditions
Sub-category: Complications of Trauma
Symptoms:
fever or hypothermia; tachycardia; low blood pressure; confusion; rapid breathing; warm or cold extremities; decreased urine output; chills
Root Cause:
Severe infection leading to widespread inflammation, blood vessel dilation, and impaired blood flow, resulting in low blood pressure and organ dysfunction.
How it's Diagnosed: videos
Diagnosis involves clinical symptoms of sepsis, blood cultures, imaging to identify the source of infection, and laboratory tests (e.g., white blood cell count, lactate levels).
Treatment:
Early antibiotic therapy, intravenous fluids to maintain blood pressure, vasopressors (e.g., norepinephrine), and supportive care for organ function.
Medications:
Antibiotics (e.g., broad-spectrum agents like meropenem , piperacillin-tazobactam), vasopressors (e.g., norepinephrine , dopamine), and corticosteroids in some cases.
Prevalence:
How common the health condition is within a specific population.
Septic shock occurs in approximately 10-15% of patients with severe sepsis.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Immunocompromised patients, recent surgery, chronic illnesses like diabetes or liver disease, invasive devices, older age.
Prognosis:
The expected outcome or course of the condition over time.
Prognosis can be improved with early diagnosis and treatment, but the risk of death is high without timely intervention. Mortality rate can be as high as 30-50%.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Organ failure (kidneys, lungs, liver), disseminated intravascular coagulation (DIC), prolonged hospitalization, and multi-organ failure.
Hypernatremia
Specialty: Nephrology
Category: Electrolyte and Acid-Base Disorders
Symptoms:
thirst; confusion; irritability; muscle twitching; weakness; seizures; coma in severe cases
Root Cause:
Elevated sodium concentration in the blood due to water loss exceeding sodium loss or excessive sodium intake.
How it's Diagnosed: videos
Blood tests measuring serum sodium levels (>145 mEq/L) and clinical evaluation of symptoms.
Treatment:
Gradual rehydration with hypotonic or isotonic fluids, addressing the underlying cause of water loss.
Medications:
No specific medications; treatment focuses on fluid replacement and correcting underlying conditions like diabetes insipidus with desmopressin .
Prevalence:
How common the health condition is within a specific population.
Less common than hyponatremia; more frequent in elderly patients and those with limited access to water.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Dehydration, diabetes insipidus, hyperaldosteronism, osmotic diuresis, and impaired thirst mechanism.
Prognosis:
The expected outcome or course of the condition over time.
Good if addressed early, but severe cases can result in brain shrinkage, bleeding, or death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Cerebral bleeding, thrombosis, and neurological damage.
Metabolic Acidosis
Specialty: Nephrology
Category: Acid-Base Disorders
Symptoms:
rapid breathing (kussmaul respirations); fatigue; confusion; headache; nausea; vomiting; low blood pressure in severe cases
Root Cause:
Accumulation of acid or loss of bicarbonate in the body due to kidney dysfunction, increased acid production, or bicarbonate loss.
How it's Diagnosed: videos
Blood gas analysis (low pH, low bicarbonate), anion gap calculation, and electrolyte tests.
Treatment:
Address the underlying cause (e.g., correcting lactic acidosis or ketoacidosis), bicarbonate therapy in severe cases, and supportive care.
Medications:
Sodium bicarbonate (buffer agent), dichloroacetate (used experimentally in certain types of metabolic acidosis).
Prevalence:
How common the health condition is within a specific population.
Common in hospitalized patients, particularly those in critical care settings.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Chronic kidney disease, diabetes (ketoacidosis), sepsis, and diarrhea.
Prognosis:
The expected outcome or course of the condition over time.
Dependent on the underlying cause; prompt treatment generally leads to a favorable outcome.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Cardiac arrhythmias, shock, and multiorgan failure if untreated.
Metabolic Alkalosis
Specialty: Nephrology
Category: Acid-Base Disorders
Symptoms:
muscle cramps; weakness; tetany; paresthesias; confusion; irritability; arrhythmias
Root Cause:
Excessive bicarbonate or loss of acid due to vomiting, diuretics, or endocrine disorders.
How it's Diagnosed: videos
Blood gas analysis (elevated pH, elevated bicarbonate), and assessment of chloride and potassium levels.
Treatment:
Address underlying cause, chloride or potassium supplementation, and intravenous saline in saline-responsive cases.
Medications:
Potassium chloride (electrolyte supplement), acetazolamide (carbonic anhydrase inhibitor).
Prevalence:
How common the health condition is within a specific population.
Common in hospitalized patients, especially those on diuretics.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Chronic diuretic use, vomiting, and adrenal gland disorders.
Prognosis:
The expected outcome or course of the condition over time.
Good with proper treatment; prolonged cases may cause complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Cardiac arrhythmias, hypokalemia, and seizures.
Respiratory Acidosis (secondary to renal issues)
Specialty: Nephrology
Category: Acid-Base Disorders
Symptoms:
confusion; fatigue; shortness of breath; headache; cyanosis; drowsiness; tremors
Root Cause:
Impaired CO2 elimination by the lungs, with kidneys unable to adequately compensate by increasing bicarbonate reabsorption.
How it's Diagnosed: videos
Blood gas analysis (low pH, elevated pCO2), kidney function tests, and imaging of the lungs.
Treatment:
Improve ventilation (mechanical ventilation if needed), treat underlying renal dysfunction, and correct any electrolyte imbalances.
Medications:
Bronchodilators (e.g., albuterol for reversible airway obstruction), bicarbonate therapy (in severe cases).
Prevalence:
How common the health condition is within a specific population.
More common in patients with chronic lung disease and renal dysfunction.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Chronic obstructive pulmonary disease (COPD), renal failure, and neuromuscular disorders.
Prognosis:
The expected outcome or course of the condition over time.
Dependent on the reversibility of the underlying causes; timely intervention improves outcomes.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Coma, cardiac arrhythmias, and respiratory failure.
Respiratory Alkalosis (secondary to renal issues)
Specialty: Nephrology
Category: Acid-Base Disorders
Symptoms:
dizziness; lightheadedness; paresthesias; tetany; confusion; chest pain
Root Cause:
Excessive CO2 elimination (hyperventilation), with the kidneys unable to adequately reduce bicarbonate levels.
How it's Diagnosed: videos
Blood gas analysis (elevated pH, low pCO2), and kidney function evaluation.
Treatment:
Treat underlying cause (e.g., anxiety, hypoxemia), slow breathing rate, and correct electrolyte imbalances.
Medications:
Benzodiazepines (e.g., lorazepam for anxiety-induced hyperventilation), no direct renal medications.
Prevalence:
How common the health condition is within a specific population.
Rare; seen in critically ill patients or with severe anxiety disorders.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Anxiety, pulmonary disease, sepsis, and renal dysfunction.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with proper management of the underlying cause.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Hypocalcemia, cardiac arrhythmias, and seizures in severe cases.
Hemolytic Uremic Syndrome (HUS)
Specialty: Nephrology
Category: Vascular Kidney Diseases
Sub-category: Thrombotic Microangiopathies
Symptoms:
pale skin; fatigue; bloody diarrhea; reduced urination; swelling; bruising; confusion; high blood pressure
Root Cause:
HUS is caused by damage to the small blood vessels in the kidneys, often due to Shiga toxin-producing Escherichia coli (STEC), leading to hemolysis, thrombocytopenia, and acute kidney injury.
How it's Diagnosed: videos
Diagnosis involves clinical history (e.g., recent diarrheal illness), blood tests (low hemoglobin, elevated creatinine, fragmented red blood cells on a peripheral smear), stool tests for Shiga toxin, and ADAMTS13 enzyme activity (to rule out TTP).
Treatment:
Treatment includes supportive care such as fluid management, dialysis for severe kidney failure, blood transfusions if needed, and sometimes plasma exchange or eculizumab (in atypical HUS).
Medications:
Treatment may include Eculizumab (a monoclonal antibody targeting complement protein C5, used for atypical HUS), antihypertensive agents (for blood pressure control), and antiplatelet drugs (in certain cases of atypical HUS).
Prevalence:
How common the health condition is within a specific population.
HUS is rare, with an incidence of about 2 cases per 100,000 people per year in developed countries.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Consumption of contaminated food, recent gastrointestinal infections (especially with Shiga toxin-producing E. coli), genetic mutations in complement regulation (atypical HUS), and immune suppression.
Prognosis:
The expected outcome or course of the condition over time.
With prompt treatment, many patients recover, although atypical HUS has a higher risk of recurrence and long-term complications. Chronic kidney disease or end-stage renal disease may develop in severe cases.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Kidney failure, neurological complications (e.g., seizures, stroke), high blood pressure, and chronic kidney disease.
Tumor Lysis Syndrome (leading to AKI)
Specialty: Nephrology
Category: Oncological Renal Complications
Symptoms:
nausea and vomiting; weakness; muscle cramps; confusion; decreased urine output; irregular heartbeat
Root Cause:
Rapid breakdown of tumor cells releases intracellular ions (potassium and phosphate) and nucleic acids into the bloodstream, causing hyperkalemia, hyperphosphatemia, hypocalcemia, and uric acid buildup, leading to acute kidney injury.
How it's Diagnosed: videos
Laboratory tests revealing hyperkalemia, hyperphosphatemia, hypocalcemia, and hyperuricemia; urinalysis and imaging to assess kidney function.
Treatment:
Aggressive hydration, correction of electrolyte imbalances, and use of urate-lowering medications like rasburicase or allopurinol. Dialysis may be necessary in severe cases.
Medications:
Medications include xanthine oxidase inhibitors (e.g., allopurinol ) to prevent uric acid formation and recombinant urate oxidase (e.g., rasburicase ) to break down uric acid. Electrolyte-modifying agents like calcium gluconate may be used for hyperkalemia.
Prevalence:
How common the health condition is within a specific population.
More common in patients undergoing treatment for hematologic cancers like lymphoma and leukemia.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
High tumor burden, chemotherapy or radiation therapy, preexisting kidney dysfunction, and high uric acid levels.
Prognosis:
The expected outcome or course of the condition over time.
Good with early identification and treatment; severe cases can lead to chronic kidney disease or death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Acute kidney injury, severe electrolyte imbalances, cardiac arrhythmias, seizures, and multiorgan failure.
Hypercalcemia of Malignancy
Specialty: Oncology
Category: Sarcomas
Sub-category: Paraneoplastic Syndromes
Symptoms:
nausea; vomiting; constipation; abdominal pain; fatigue; confusion; thirst; frequent urination; muscle weakness
Root Cause:
Malignant tumors release calcium into the bloodstream, often through secretion of parathyroid hormone-related protein (PTHrP) or osteolytic bone metastasis.
How it's Diagnosed: videos
Blood tests showing elevated calcium levels, alongside confirmation of underlying malignancy through imaging or biopsy.
Treatment:
Hydration, bisphosphonates (such as zoledronic acid), denosumab, corticosteroids, and calcitonin.
Medications:
Bisphosphonates (e.g., zoledronic acid) inhibit bone resorption, and denosumab , a monoclonal antibody, works by inhibiting osteoclast activity. Corticosteroids (e.g., dexamethasone ) may be used if there is an underlying hematologic malignancy. Calcitonin helps to lower calcium levels by inhibiting osteoclast function.
Prevalence:
How common the health condition is within a specific population.
Affects approximately 10-20% of patients with advanced cancer.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Patients with lung, breast, or hematologic cancers, and those with extensive bone metastasis.
Prognosis:
The expected outcome or course of the condition over time.
The prognosis depends on the underlying malignancy and the ability to control calcium levels. Treatment of the underlying cancer can improve the prognosis.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Severe hypercalcemia can cause kidney failure, arrhythmias, coma, and, if untreated, death.
Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH)
Specialty: Oncology
Category: Sarcomas
Sub-category: Paraneoplastic Syndromes
Symptoms:
hyponatremia; nausea; vomiting; confusion; seizures; lethargy; muscle cramps
Root Cause:
Tumors produce excess antidiuretic hormone (ADH), leading to water retention and dilutional hyponatremia.
How it's Diagnosed: videos
Blood tests showing low sodium levels and high urine osmolality despite low serum osmolality. Imaging to identify the tumor may also be necessary.
Treatment:
Fluid restriction, hypertonic saline in severe cases, and vasopressin receptor antagonists (e.g., tolvaptan). Treating the underlying cancer may improve SIADH.
Medications:
Vasopressin receptor antagonists (e.g., tolvaptan ) help correct sodium imbalances by blocking the effects of ADH.
Prevalence:
How common the health condition is within a specific population.
Common in patients with small cell lung cancer, as well as other malignancies like head and neck cancers.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Small cell lung cancer, brain tumors, and medications such as cyclophosphamide or vincristine.
Prognosis:
The expected outcome or course of the condition over time.
Prognosis depends on the underlying malignancy and successful management of fluid imbalances.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
If untreated, SIADH can lead to severe hyponatremia, seizures, and coma.
Acute Intermittent Porphyria (AIP)
Specialty: Hematology
Category: Heme Synthesis and Disorders
Symptoms:
abdominal pain; nausea; vomiting; constipation; muscle weakness; confusion; anxiety; seizures; dark-colored urine
Root Cause:
Deficiency of the enzyme porphobilinogen deaminase (PBGD), leading to the accumulation of heme precursors such as delta-aminolevulinic acid (ALA) and porphobilinogen (PBG).
How it's Diagnosed: videos
Measurement of urinary porphobilinogen (PBG) levels during an acute attack; genetic testing to confirm enzyme mutations.
Treatment:
Avoiding triggers (e.g., certain drugs, fasting, stress), intravenous administration of hemin, high carbohydrate intake during attacks.
Medications:
Hemin (a heme analog used to suppress heme synthesis); glucose infusions for mild attacks to inhibit ALA synthase.
Prevalence:
How common the health condition is within a specific population.
Affects approximately 1 in 20,000 individuals; more common in women than men.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Female sex, hormonal fluctuations, certain medications (e.g., barbiturates, sulfa drugs), fasting, alcohol consumption.
Prognosis:
The expected outcome or course of the condition over time.
With proper management, acute attacks are treatable; however, untreated attacks can lead to complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Permanent neurological damage, chronic pain, liver cancer (in rare cases).
Methemoglobinemia
Specialty: Hematology
Category: Red Blood Cells and Disorders
Symptoms:
cyanosis (bluish skin, especially lips and fingers); shortness of breath; fatigue; confusion; headache; dizziness; tachycardia; loss of consciousness in severe cases
Root Cause:
Elevated levels of methemoglobin (an oxidized form of hemoglobin that cannot bind oxygen effectively) in the blood, leading to reduced oxygen delivery to tissues.
How it's Diagnosed: videos
Arterial blood gas analysis showing low oxygen saturation despite normal oxygen levels, co-oximetry detecting elevated methemoglobin levels, and a chocolate-brown appearance of arterial blood.
Treatment:
Treatment depends on severity. Methylene blue (an antidote) is administered intravenously in severe cases. Ascorbic acid may also help in mild cases. Removal of the causative agent (e.g., drugs or toxins) is crucial.
Medications:
Methylene blue — a reducing agent to convert methemoglobin back to functional hemoglobin. Ascorbic acid (Vitamin C) — classified as an antioxidant, used in mild chronic cases.
Prevalence:
How common the health condition is within a specific population.
Rare; often seen in people exposed to oxidizing agents (e.g., nitrates, dapsone, or benzocaine). Can also be congenital due to genetic mutations.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
exposure to oxidizing drugs or chemicals; genetic predisposition (e.g., cytochrome b5 reductase deficiency); infants under 6 months (due to immature enzyme systems); industrial exposure to nitrates
Prognosis:
The expected outcome or course of the condition over time.
Prognosis is excellent with prompt treatment. Chronic or untreated cases may result in tissue hypoxia and severe complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
hypoxia; seizures; cardiovascular collapse; death in severe untreated cases
Acetaminophen (Paracetamol) Toxicity
Specialty: Toxicology
Category: Acute Poisoning
Sub-category: Pharmaceutical Overdoses
Symptoms:
nausea; vomiting; abdominal pain; jaundice; confusion; fatigue
Root Cause:
Excessive intake of acetaminophen overwhelms liver detoxification pathways, leading to toxic accumulation of N-acetyl-p-benzoquinone imine (NAPQI), a metabolite that causes liver damage.
How it's Diagnosed: videos
Diagnosed with serum acetaminophen levels and liver function tests.
Treatment:
Treated with N-acetylcysteine (NAC) to replenish glutathione and prevent liver damage.
Medications:
N-acetylcysteine (NAC) is the antidote for acetaminophen toxicity. It belongs to the class of mucolytics and glutathione precursors.
Prevalence:
How common the health condition is within a specific population.
Acetaminophen toxicity is one of the most common causes of acute liver failure globally, with thousands of cases reported annually.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Overdose (intentional or accidental), chronic alcohol use, malnutrition, or concurrent use of medications that induce cytochrome P450 enzymes (e.g., certain anticonvulsants).
Prognosis:
The expected outcome or course of the condition over time.
Good if treated promptly; severe cases can lead to acute liver failure and death if untreated.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Acute liver failure, hepatic encephalopathy, kidney injury, and death in severe cases.
Aspirin (Salicylate) Poisoning
Specialty: Toxicology
Category: Acute Poisoning
Sub-category: Pharmaceutical Overdoses
Symptoms:
nausea; vomiting; hyperventilation; ringing in the ears (tinnitus); confusion; seizures; coma
Root Cause:
Excessive salicylates disrupt metabolic pathways, causing respiratory alkalosis, metabolic acidosis, and increased energy expenditure.
How it's Diagnosed: videos
Diagnosed by serum salicylate levels and blood gas analysis
Treatment:
Treated with activated charcoal, IV sodium bicarbonate for alkalinization, and hemodialysis in severe cases.
Medications:
Sodium bicarbonate is used to alkalinize urine; it is an alkalinizing agent. No specific antidote exists.
Prevalence:
How common the health condition is within a specific population.
Less common due to decreased aspirin use in children but still a concern in adults and intentional overdoses.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Intentional overdose, chronic use, impaired kidney function, or co-ingestion with other medications.
Prognosis:
The expected outcome or course of the condition over time.
Good with early treatment; severe cases can result in multi-organ failure and death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Pulmonary edema, cerebral edema, seizures, and renal failure.
Organophosphate and carbamate insecticide poisoning
Specialty: Toxicology
Category: Acute Poisoning
Sub-category: Chemical Poisoning
Symptoms:
nausea; vomiting; diarrhea; salivation; lacrimation (tearing); urination; muscle twitching; confusion; seizures; respiratory distress; bradycardia; miosis (pupil constriction)
Root Cause:
Inhibition of acetylcholinesterase enzyme, leading to an accumulation of acetylcholine at synapses and overstimulation of the nervous system.
How it's Diagnosed: videos
Clinical history of exposure, symptoms presentation, blood cholinesterase levels (low levels indicate poisoning).
Treatment:
Decontamination (removal of contaminated clothing, washing skin), administration of atropine (to counteract muscarinic effects) and pralidoxime (to reactivate acetylcholinesterase), supportive care (oxygen, fluids).
Medications:
Atropine (anticholinergic agent), pralidoxime (cholinesterase reactivator), benzodiazepines (e.g., diazepam or lorazepam ) for seizures.
Prevalence:
How common the health condition is within a specific population.
Common in agricultural regions where these insecticides are widely used; estimated to cause hundreds of thousands of poisonings annually worldwide.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Occupational exposure (farmers, pesticide applicators), improper storage or handling, intentional ingestion (suicide attempt).
Prognosis:
The expected outcome or course of the condition over time.
Favorable with prompt treatment; delayed treatment can lead to severe complications or death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Respiratory failure, prolonged muscle weakness (intermediate syndrome), long-term neurological dysfunction.
Cyanide poisoning
Specialty: Toxicology
Category: Acute Poisoning
Sub-category: Chemical Poisoning
Symptoms:
headache; confusion; seizures; shortness of breath; cardiac arrhythmias; cherry-red skin coloration (rare); metabolic acidosis; coma
Root Cause:
Inhibition of cytochrome c oxidase in the mitochondria, leading to cellular hypoxia and metabolic failure despite adequate oxygenation.
How it's Diagnosed: videos
Clinical history of exposure, symptoms presentation, blood cyanide levels, and arterial blood gases (showing metabolic acidosis).
Treatment:
Administration of hydroxocobalamin (binds cyanide to form cyanocobalamin), sodium thiosulfate (enhances cyanide detoxification), and supportive care (oxygen therapy).
Medications:
Hydroxocobalamin (cyanide antidote), sodium thiosulfate (sulfur donor for detoxification), amyl nitrite or sodium nitrite (optional, promotes methemoglobin formation).
Prevalence:
How common the health condition is within a specific population.
Rare in industrialized countries but associated with fires, industrial exposure, and intentional poisoning.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Smoke inhalation from fires, occupational exposure (e.g., mining, metal plating), ingestion of cyanide-containing compounds.
Prognosis:
The expected outcome or course of the condition over time.
Good with rapid intervention; delay in treatment can result in death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Neurological damage, cardiopulmonary arrest, lactic acidosis.
Carbon monoxide poisoning
Specialty: Toxicology
Category: Acute Poisoning
Sub-category: Chemical Poisoning
Symptoms:
headache; dizziness; nausea; vomiting; confusion; chest pain; shortness of breath; loss of consciousness; seizures; coma
Root Cause:
Carbon monoxide binds to hemoglobin with greater affinity than oxygen, forming carboxyhemoglobin, which reduces oxygen delivery to tissues and causes cellular hypoxia.
How it's Diagnosed: videos
Clinical history, carboxyhemoglobin levels via blood gas analysis, pulse CO-oximetry (if available).
Treatment:
Removal from exposure source, administration of 100% oxygen, hyperbaric oxygen therapy in severe cases.
Medications:
No specific medications; 100% oxygen or hyperbaric oxygen therapy is the treatment of choice.
Prevalence:
How common the health condition is within a specific population.
Common, particularly in poorly ventilated areas with gas heaters, car exhaust, or during fire incidents.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Indoor use of gas appliances, fires, motor vehicle exhaust, faulty heating systems.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with early treatment; delayed treatment can result in neurological sequelae or death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Hypoxic brain injury, delayed neuropsychiatric syndrome (DNS), arrhythmias, myocardial ischemia.
Cocaine overdose
Specialty: Toxicology
Category: Acute Poisoning
Sub-category: Chemical Poisoning
Symptoms:
chest pain; rapid heart rate; high blood pressure; agitation; seizures; hyperthermia; confusion; respiratory depression
Root Cause:
Excessive stimulation of the central nervous system and cardiovascular system due to toxic levels of cocaine, leading to dopamine, norepinephrine, and serotonin overload.
How it's Diagnosed: videos
Clinical evaluation based on symptoms, history of cocaine use, and toxicology screening (urine or blood tests).
Treatment:
Supportive care, sedation with benzodiazepines, cooling for hyperthermia, intravenous fluids, and treatment of cardiovascular complications.
Medications:
Benzodiazepines (e.g., lorazepam or diazepam ) for agitation and seizures; antihypertensives like labetalol for severe hypertension; sodium bicarbonate for arrhythmias due to cocaine-induced acidosis.
Prevalence:
How common the health condition is within a specific population.
Cocaine-related overdoses account for thousands of emergency visits annually, with increasing trends in recent years.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
High-dose cocaine use, concurrent use of other stimulants or alcohol, preexisting heart disease, and lack of access to timely medical care.
Prognosis:
The expected outcome or course of the condition over time.
Good if treated promptly, though delayed treatment or severe complications (e.g., cardiac arrest or stroke) can lead to long-term damage or death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Stroke, myocardial infarction, rhabdomyolysis, acute kidney injury, and sudden death.
MDMA (ecstasy) toxicity
Specialty: Toxicology
Category: Acute Poisoning
Sub-category: Chemical Poisoning
Symptoms:
hyperthermia; tachycardia; hypertension; jaw clenching; agitation; confusion; seizures; low sodium levels (hyponatremia)
Root Cause:
Excessive serotonin release, leading to serotonin syndrome and severe dehydration or hyponatremia.
How it's Diagnosed: videos
Clinical evaluation, history of MDMA use, and toxicology tests.
Treatment:
Cooling for hyperthermia, benzodiazepines for agitation or seizures, intravenous fluids for dehydration, and management of serotonin syndrome.
Medications:
Benzodiazepines (e.g., diazepam ) for agitation and seizures; cyproheptadine for serotonin syndrome in severe cases; intravenous saline for correcting hyponatremia.
Prevalence:
How common the health condition is within a specific population.
MDMA-related toxicity is common among recreational users, particularly at music festivals or clubs.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
High doses, mixing MDMA with other substances, prolonged dancing or lack of hydration, and underlying health conditions.
Prognosis:
The expected outcome or course of the condition over time.
Favorable with prompt treatment; delayed care can lead to life-threatening complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Serotonin syndrome, severe dehydration, rhabdomyolysis, liver or kidney failure, and death.
Synthetic cannabinoids toxicity
Specialty: Toxicology
Category: Acute Poisoning
Sub-category: Chemical Poisoning
Symptoms:
confusion; anxiety; paranoia; seizures; hypertension; nausea; vomiting; chest pain
Root Cause:
Overactivation of cannabinoid receptors by synthetic chemicals, leading to unpredictable and exaggerated physiological and psychological effects.
How it's Diagnosed: videos
History of synthetic cannabinoid use, clinical symptoms, and toxicology testing (though specific detection is often limited).
Treatment:
Supportive care, benzodiazepines for agitation or seizures, antiemetics for nausea, and cardiovascular monitoring.
Medications:
Benzodiazepines (e.g., lorazepam ) for agitation and seizures; antiemetics like ondansetron for nausea and vomiting.
Prevalence:
How common the health condition is within a specific population.
Increasingly reported due to the availability of synthetic cannabinoids as a legal alternative to cannabis in some regions.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Use of synthetic cannabinoids, mixing with other substances, and lack of knowledge about the specific chemical consumed.
Prognosis:
The expected outcome or course of the condition over time.
Most cases resolve with supportive care, but severe toxicity can lead to life-threatening complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Acute kidney injury, seizures, psychosis, and cardiac arrhythmias.
Acute Alcohol Intoxication
Specialty: Toxicology
Category: Acute Poisoning
Sub-category: Alcohol-Related Toxicity
Symptoms:
slurred speech; impaired coordination; confusion; vomiting; stupor; respiratory depression; hypothermia; coma
Root Cause:
Central nervous system depression caused by excessive alcohol consumption leading to toxic blood alcohol concentrations.
How it's Diagnosed: videos
Clinical presentation (history and physical exam), measurement of blood alcohol concentration (BAC), and ruling out other causes of altered mental status.
Treatment:
Supportive care, airway management, oxygen if needed, intravenous fluids, correction of hypoglycemia, and monitoring for complications like aspiration or hypothermia.
Medications:
No specific antidote; thiamine (vitamin B1) is often administered to prevent Wernicke's encephalopathy in high-risk individuals.
Prevalence:
How common the health condition is within a specific population.
Common; affects millions globally, particularly in individuals who binge drink or have alcohol use disorders.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Excessive alcohol consumption, binge drinking, low body weight, underlying liver disease, concurrent use of sedatives or opioids.
Prognosis:
The expected outcome or course of the condition over time.
Typically resolves with prompt treatment; severe cases may lead to death if untreated.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Aspiration pneumonia, hypothermia, seizures, brain damage from hypoxia, and death.
Methanol Poisoning
Specialty: Toxicology
Category: Acute Poisoning
Sub-category: Alcohol-Related Toxicity
Symptoms:
headache; nausea; vomiting; blurred vision; metabolic acidosis; confusion; seizures; blindness; coma
Root Cause:
Metabolism of methanol to formic acid leads to severe metabolic acidosis and optic nerve toxicity.
How it's Diagnosed: videos
Measurement of serum methanol levels, metabolic acidosis with increased anion and osmolal gap, and clinical symptoms.
Treatment:
Administration of fomepizole or ethanol to inhibit alcohol dehydrogenase, correction of acidosis with bicarbonate, and hemodialysis to remove methanol and formic acid.
Medications:
Fomepizole or ethanol (alcohol dehydrogenase inhibitors); sodium bicarbonate for acidosis.
Prevalence:
How common the health condition is within a specific population.
Rare; occurs due to ingestion of adulterated alcohol or industrial exposure.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Access to methanol-containing products, substance misuse, occupational hazards.
Prognosis:
The expected outcome or course of the condition over time.
With early treatment, prognosis is good; delayed treatment can result in blindness or death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Permanent blindness, multi-organ failure, death.
Arsenic Poisoning
Specialty: Toxicology
Category: Chronic Toxicity and Long-Term Exposures
Sub-category: Heavy Metal Toxicity
Symptoms:
nausea; vomiting; abdominal pain; diarrhea; darkened skin patches; thickened skin on palms and soles; fatigue; peripheral neuropathy; confusion; muscle cramps
Root Cause:
Accumulation of arsenic in the body due to exposure to contaminated drinking water, industrial processes, or arsenic-containing pesticides. Arsenic disrupts cellular metabolism, DNA repair, and oxidative processes.
How it's Diagnosed: videos
Diagnosis is made through urine arsenic levels (preferred for recent exposure) or hair and nail analysis for chronic exposure. Clinical symptoms and exposure history are also key.
Treatment:
Treatment includes cessation of exposure, supportive care for symptoms, and chelation therapy for severe cases. Ensuring access to safe water sources is critical.
Medications:
Chelating agents such as dimercaprol and succimer (DMSA) are used to bind arsenic and enhance excretion. The choice of medication depends on the severity of poisoning.
Prevalence:
How common the health condition is within a specific population.
Arsenic poisoning is prevalent in regions with contaminated groundwater, particularly in South Asia (e.g., Bangladesh, India) and parts of South America.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Drinking arsenic-contaminated water, occupational exposure (e.g., smelting, mining), use of arsenic-based pesticides, and ingestion of contaminated food.
Prognosis:
The expected outcome or course of the condition over time.
Early intervention and cessation of exposure can lead to symptom improvement. However, prolonged exposure can result in irreversible damage and increased cancer risk.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Long-term complications include skin lesions, peripheral neuropathy, cardiovascular diseases, diabetes, and increased risks of cancers (e.g., skin, lung, bladder).
Solvent Toxicity (e.g., Benzene, Toluene)
Specialty: Toxicology
Category: Chronic Toxicity and Long-Term Exposures
Sub-category: Occupational and Environmental Exposures
Symptoms:
headache; dizziness; confusion; memory loss; nausea; fatigue; respiratory distress; skin irritation
Root Cause:
Prolonged exposure to solvents causes central nervous system depression, bone marrow suppression, and organ toxicity.
How it's Diagnosed: videos
Blood tests for solvent levels or metabolites, bone marrow biopsy, and neurological assessments.
Treatment:
Avoidance of exposure, supportive care, and treating complications (e.g., bone marrow suppression).
Medications:
Chelating agents like dimercaprol or succimer may be used for heavy solvent exposure with metal components. Symptomatic treatments include antiemetics for nausea or anxiolytics for agitation.
Prevalence:
How common the health condition is within a specific population.
Found in industrial settings (painting, printing, chemical production); exposure is common globally.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Occupational exposure, inadequate ventilation, improper handling of solvents.
Prognosis:
The expected outcome or course of the condition over time.
Varies with exposure level; chronic exposure may lead to irreversible organ damage or cancer.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Leukemia (benzene exposure), kidney or liver damage, and neurological disorders.
Toxic effects of solvents (e.g., paint thinners, glues)
Specialty: Toxicology
Category: Acute and Chronic Toxicity
Sub-category: Industrial Chemicals and Solvents
Symptoms:
dizziness; headache; confusion; nausea; vomiting; dermatitis; irritation of the respiratory system; fatigue; memory impairment with chronic exposure
Root Cause:
Solvents cause toxicity through inhalation, ingestion, or skin absorption, leading to damage to the central nervous system, respiratory system, and skin. Chronic exposure can result in neurotoxicity.
How it's Diagnosed: videos
Diagnosis is based on exposure history, clinical symptoms, imaging (e.g., chest X-ray or MRI for neurological effects), and laboratory tests to detect solvent metabolites in blood or urine.
Treatment:
Immediate treatment involves removing the person from exposure, providing supportive care, oxygen therapy for respiratory distress, and treating systemic effects. Skin exposure requires thorough washing.
Medications:
Medications depend on symptoms
Prevalence:
How common the health condition is within a specific population.
Common among industrial workers, painters, and individuals using glue for recreational inhalation ("huffing").
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Occupational exposure, recreational inhalant use, inadequate protective measures, and prolonged use in poorly ventilated spaces.
Prognosis:
The expected outcome or course of the condition over time.
Acute exposures often resolve with appropriate care, but chronic exposure may lead to irreversible neurological damage.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Peripheral neuropathy, chronic headaches, liver damage, and kidney damage.
Foxglove (digitalis) toxicity
Specialty: Toxicology
Category: Biological and Natural Toxins
Sub-category: Plant Toxins
Symptoms:
nausea; vomiting; diarrhea; abdominal pain; confusion; visual disturbances (e.g., seeing halos around lights); irregular heart rhythms
Root Cause:
Digitalis compounds interfere with sodium-potassium ATPase in cardiac cells, leading to increased intracellular calcium and altered heart function.
How it's Diagnosed: videos
Clinical presentation, history of foxglove exposure or ingestion, and elevated serum digoxin levels.
Treatment:
Activated charcoal (if ingestion is recent), digoxin-specific antibody fragments (Digibind), and management of arrhythmias (e.g., with anti-arrhythmic drugs or temporary pacing).
Medications:
Digibind (digoxin-specific antibody fragments); anti-arrhythmics like lidocaine may be used for ventricular arrhythmias.
Prevalence:
How common the health condition is within a specific population.
Rare in modern contexts; usually due to accidental ingestion or misuse of foxglove extracts.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Accidental ingestion, herbal remedy misuse, or overdose of digoxin-containing medications.
Prognosis:
The expected outcome or course of the condition over time.
Good with early recognition and treatment; severe cases can be life-threatening.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Life-threatening arrhythmias, cardiac arrest, neurological complications (e.g., seizures).
Amanita Mushroom Poisoning
Specialty: Toxicology
Category: Biological and Natural Toxins
Sub-category: Foodborne and Natural Toxins
Symptoms:
nausea; vomiting; abdominal pain; diarrhea; jaundice; liver failure; renal failure; confusion; seizures
Root Cause:
The ingestion of Amanita mushrooms, especially species like Amanita phalloides (death cap), which contain potent toxins (amatoxins) that damage the liver and kidneys.
How it's Diagnosed: videos
Diagnosis is based on clinical history (ingestion of suspected mushrooms), clinical symptoms, and laboratory tests (e.g., liver function tests, mushroom identification). Detection of amatoxins in urine may confirm diagnosis.
Treatment:
Treatment involves supportive care (e.g., intravenous fluids, liver dialysis), and in severe cases, liver transplantation may be required. Antidotes like silibinin (milk thistle extract) and N-acetylcysteine may help.
Medications:
Antidotes such as silibinin (a liver protectant) and N-acetylcysteine (used for liver support) may be prescribed. In some cases, activated charcoal is used if the mushroom was ingested recently.
Prevalence:
How common the health condition is within a specific population.
Amanita mushroom poisoning is rare but serious, often occurring during the mushroom-picking season, typically in temperate climates.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Mushroom foraging, especially by individuals who may confuse toxic species with edible ones. Lack of mushroom identification expertise.
Prognosis:
The expected outcome or course of the condition over time.
If treated early, the prognosis may be improved. However, poisoning can lead to severe liver and kidney damage or death if not addressed promptly.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Liver failure, renal failure, long-term organ damage, and death in severe cases.
Anesthetic toxicity (e.g., lidocaine, bupivacaine)
Specialty: Toxicology
Category: Adverse Effects of Therapeutics and Medical Agents
Sub-category: Iatrogenic Conditions
Symptoms:
numbness; tingling; seizures; dizziness; difficulty breathing; arrhythmias; cardiovascular collapse; confusion
Root Cause:
Overdose or unintended systemic absorption of local anesthetics leading to central nervous system and cardiovascular toxicity.
How it's Diagnosed: videos
Diagnosis is based on clinical presentation and history of recent local anesthetic administration; blood levels of the anesthetic can confirm toxicity.
Treatment:
Immediate discontinuation of the anesthetic, intravenous lipid emulsion therapy, supportive care (oxygen, airway management, and monitoring), and anticonvulsants for seizures (e.g., benzodiazepines).
Medications:
Medications include intravenous lipid emulsion therapy (as a treatment to counteract toxicity), anticonvulsants like lorazepam or diazepam (sedatives and anticonvulsants), and vasopressors (such as epinephrine) if required for managing cardiovascular symptoms.
Prevalence:
How common the health condition is within a specific population.
Rare, but incidence is higher in patients with high doses or when multiple injections are administered, especially in high-risk procedures.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
High doses of local anesthetics, accidental intravenous injection, renal or hepatic insufficiency, prolonged duration of anesthesia, and use of multiple anesthetics simultaneously.
Prognosis:
The expected outcome or course of the condition over time.
Typically reversible with appropriate treatment; mortality is rare but possible with delayed or inadequate intervention.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Seizures, cardiovascular collapse, neurological deficits, arrhythmias, and in extreme cases, death.
Hyperammonemia (e.g., from liver failure)
Specialty: Toxicology
Category: Endogenous Toxins
Sub-category: Hepatic Disorders
Symptoms:
confusion; lethargy; vomiting; irritability; tremors; seizures; coma
Root Cause:
Excess ammonia in the bloodstream due to impaired liver function or inherited metabolic disorders, leading to neurotoxicity.
How it's Diagnosed: videos
Blood tests showing elevated ammonia levels; clinical symptoms; imaging (e.g., CT or MRI) to rule out other causes of neurological dysfunction; genetic testing for inherited disorders.
Treatment:
Lactulose (a non-absorbable sugar) to trap ammonia in the gut, rifaximin to reduce ammonia-producing bacteria, supportive care, and addressing the underlying cause such as liver transplantation in severe cases.
Medications:
Lactulose (osmotic laxative), rifaximin (intestinal antibiotic), sodium benzoate , and sodium phenylbutyrate (ammonia-scavenging agents).
Prevalence:
How common the health condition is within a specific population.
Common in individuals with cirrhosis or acute liver failure; also occurs in certain inherited urea cycle disorders.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Liver cirrhosis, acute liver failure, high-protein diet in susceptible individuals, inherited metabolic disorders.
Prognosis:
The expected outcome or course of the condition over time.
Treatable if addressed early; severe cases can lead to permanent neurological damage or death if untreated.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Hepatic encephalopathy, cerebral edema, coma, death.
Sepsis-related toxins (cytokine storm)
Specialty: Toxicology
Category: Endogenous Toxins
Sub-category: Pathologic Toxins
Symptoms:
fever; chills; rapid heart rate; shortness of breath; confusion; low blood pressure; organ dysfunction; rash or mottled skin; low blood pressure; organ dysfunction
Root Cause:
An excessive immune response to infection leads to widespread release of pro-inflammatory cytokines, causing systemic inflammation and organ damage.
How it's Diagnosed: videos
Clinical criteria for sepsis (qSOFA, SIRS), blood cultures, inflammatory markers (e.g., CRP, procalcitonin), and organ function tests (liver enzymes, creatinine, arterial blood gases).
Treatment:
Intravenous antibiotics, fluid resuscitation, vasopressors for low blood pressure, mechanical ventilation for respiratory failure, and immunomodulatory therapies in severe cases.us antibiotics, fluid resuscitation, vasopressors for low blood
Medications:
Broad-spectrum antibiotics (e.g., piperacillin-tazobactam, meropenem ), corticosteroids (e.g., hydrocortisone for refractory septic shock), and biologics targeting cytokines (e.g., tocilizumab for IL-6).
Prevalence:
How common the health condition is within a specific population.
Sepsis affects 49 million people annually worldwide, with cytokine storm occurring in a subset of severe cases.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Older age, chronic illnesses (e.g., diabetes, cancer), immunosuppression, major surgeries, and infections (e.g., pneumonia, urinary tract infections).
Prognosis:
The expected outcome or course of the condition over time.
High mortality rate (25–50%) in severe cases, particularly without prompt treatment; survivors may have long-term complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Septic shock, acute respiratory distress syndrome (ARDS), multiple organ failure, and long-term physical and cognitive impairments.
Rhabdomyolysis-related toxicity (myoglobin release)
Specialty: Toxicology
Category: Endogenous Toxins
Sub-category: Pathologic Toxins
Symptoms:
muscle pain; weakness; dark-colored urine; fatigue; swelling; nausea; confusion; irregular heart rhythms in severe cases; muscle pain; weakness; dark-colored urine; fatigue
Root Cause:
The breakdown of skeletal muscle releases myoglobin and other intracellular contents, leading to kidney damage and metabolic disturbances.
How it's Diagnosed: videos
Elevated creatine kinase (CK) levels, myoglobin in the urine, blood tests for electrolyte imbalances, and kidney function tests.
Treatment:
Aggressive intravenous fluid therapy to maintain urine output, correction of electrolyte imbalances, dialysis in severe kidney failure, and treating underlying causes.us fluid therapy to maintain urine output, correction of electrolyte imbalances, dialysis in severe kidney failure, and treating und
Medications:
No specific medications; supportive treatments include sodium bicarbonate or mannitol to alkalinize urine and prevent myoglobin toxicity. Electrolyte management may require potassium binders or calcium gluconate.
Prevalence:
How common the health condition is within a specific population.
Varies depending on the cause; commonly associated with trauma, extreme exercise, drug use, or infections. Incidence estimated at 26,000 cases annually in the U.S.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Traumatic injuries, prolonged immobility, heatstroke, excessive exercise, certain medications (e.g., statins, fibrates), or toxins.
Prognosis:
The expected outcome or course of the condition over time.
Favorable with early treatment, but severe cases can lead to acute kidney injury (AKI) or death if untreated.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Acute kidney failure, hyperkalemia, metabolic acidosis, compartment syndrome, and disseminated intravascular coagulation (DIC).
Accidental industrial chemical exposure
Specialty: Toxicology
Category: Occupational and Environmental Poisoning
Sub-category: Accidental Exposure
Symptoms:
skin irritation; respiratory distress; dizziness; nausea; burning sensation in eyes or throat; headache; confusion
Root Cause:
Unintended exposure to toxic chemicals (e.g., solvents, pesticides, cleaning agents) due to improper handling, leaks, or accidents in industrial settings.
How it's Diagnosed: videos
History of exposure, physical examination, toxicological screening, and air or substance sampling to identify specific chemicals.
Treatment:
Removal from exposure source, decontamination (e.g., flushing eyes or skin), supportive care (e.g., oxygen for respiratory distress), and specific antidotes if needed.
Medications:
Oxygen therapy, bronchodilators (e.g., albuterol for respiratory symptoms), corticosteroids for inflammation, or antidotes like atropine (for organophosphate poisoning). Atropine is an anticholinergic agent.
Prevalence:
How common the health condition is within a specific population.
Highly variable; depends on workplace safety protocols and the type of industry. Common in agriculture, manufacturing, and chemical processing industries.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Poor industrial safety measures, lack of personal protective equipment (PPE), inadequate training on chemical handling.
Prognosis:
The expected outcome or course of the condition over time.
Varies widely; mild exposures resolve with treatment, but severe cases (e.g., toxic inhalation or burns) can lead to long-term health issues or death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic lung disease, neurological impairment, organ damage, cancer (from long-term exposure to carcinogenic chemicals).
Alcohol-Related Psychosis
Specialty: Mental Health and Psychology
Category: Addiction
Symptoms:
hallucinations; delusions; paranoia; confusion; disorganized thoughts
Root Cause:
Chronic or excessive alcohol use disrupts neurotransmitter balance, leading to psychotic symptoms often exacerbated during withdrawal or intoxication.
How it's Diagnosed: videos
Clinical evaluation including history of alcohol use, mental health assessment, and ruling out other causes of psychosis. Blood alcohol level and liver function tests may assist diagnosis.
Treatment:
Detoxification, cessation of alcohol use, psychotherapy, and medication for symptom management.
Medications:
Antipsychotic medications (e.g., haloperidol or risperidone ) may be prescribed for acute psychotic episodes. Benzodiazepines (e.g., lorazepam or diazepam ) are often used during withdrawal to prevent seizures. Medications like naltrexone or acamprosate may be used for long-term management of alcohol dependence.
Prevalence:
How common the health condition is within a specific population.
Affects approximately 3-10% of individuals with severe alcohol use disorder.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Chronic alcohol abuse, history of mental illness, family history of addiction, acute withdrawal, or concurrent use of other substances.
Prognosis:
The expected outcome or course of the condition over time.
Symptoms may resolve with sustained abstinence from alcohol, but recurrent psychosis or relapse is possible without long-term management.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Cognitive decline, social and occupational impairment, risk of injury or self-harm, and progression to chronic psychosis if untreated.
Inhalant-Related Psychiatric Disorders
Specialty: Mental Health and Psychology
Category: Addiction
Symptoms:
euphoria; dizziness; slurred speech; lethargy; nausea; impaired coordination; mood changes; confusion; cognitive deficits
Root Cause:
Inhalants disrupt brain function by affecting neurotransmitter systems and causing hypoxia, leading to cognitive and behavioral impairments.
How it's Diagnosed: videos
Clinical history of inhalant use, behavioral assessment, and signs of exposure such as chemical odors or physical indicators (e.g., burns, rashes around the nose or mouth).
Treatment:
Psychotherapy, cognitive-behavioral therapy (CBT), and addressing co-occurring psychiatric disorders.
Medications:
No specific medications approved; supportive care may include anti-anxiety medications like SSRIs (e.g., sertraline ) for comorbid anxiety.
Prevalence:
How common the health condition is within a specific population.
Inhalant use is most common among adolescents, with 2.7% of high school students reporting use within the past year.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Adolescence, access to volatile substances, low socioeconomic status, peer influence, underlying mental health disorders.
Prognosis:
The expected outcome or course of the condition over time.
Early intervention can lead to recovery; prolonged use can cause irreversible neurological and cognitive damage.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Brain damage, organ failure, hypoxic injuries, and sudden sniffing death syndrome (SSDS).
Opioid Abuse
Specialty: Mental Health and Psychology
Category: Addiction
Symptoms:
euphoria; drowsiness; confusion; slowed breathing; constipation; withdrawal symptoms when not using
Root Cause:
Opioids bind to mu-opioid receptors in the brain, creating intense euphoria and leading to tolerance, dependence, and addiction.
How it's Diagnosed: videos
Detailed history, physical examination, and toxicology testing for opioids.
Treatment:
MAT (e.g., methadone, buprenorphine), naloxone for overdose reversal, and psychotherapy (CBT, group therapy).
Medications:
Methadone (full opioid agonist), buprenorphine (partial agonist), naltrexone (antagonist), and naloxone (emergency overdose reversal agent).
Prevalence:
How common the health condition is within a specific population.
Opioid use disorder affects approximately 2 million people in the U.S., with increasing rates linked to synthetic opioids like fentanyl.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Chronic pain conditions, overprescription of opioids, prior substance abuse, socioeconomic stress.
Prognosis:
The expected outcome or course of the condition over time.
Recovery is possible with sustained treatment, though relapse rates are high without comprehensive care.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Overdose, respiratory depression, infectious diseases, legal and social consequences.
Sedative, Hypnotic, Anxiolytic Use Disorders
Specialty: Mental Health and Psychology
Category: Addiction
Symptoms:
drowsiness; confusion; impaired memory; slurred speech; poor coordination; depression; irritability; withdrawal symptoms (e.g., tremors, anxiety, seizures)
Root Cause:
Misuse of medications like benzodiazepines or barbiturates leads to dependence and disruptions in GABAergic pathways.
How it's Diagnosed: videos
Clinical history, self-reported use, prescription monitoring programs, and urine or blood tests for specific substances.
Treatment:
Gradual tapering of the substance under medical supervision, cognitive-behavioral therapy (CBT), and support groups like Narcotics Anonymous.
Medications:
For withdrawal management, long-acting benzodiazepines (e.g., diazepam ) may be used to taper dependence; anticonvulsants (e.g., gabapentin ) for seizure prevention. Long-acting benzodiazepines act as sedatives; anticonvulsants stabilize neural activity.
Prevalence:
How common the health condition is within a specific population.
Approximately 1% of the population is affected by sedative misuse. Prevalence is higher in populations with access to these medications.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Chronic stress, insomnia, anxiety disorders, access to sedatives, and family history of substance use.
Prognosis:
The expected outcome or course of the condition over time.
With treatment, many recover fully; without treatment, risk of overdose, severe withdrawal, and relapse is high.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Respiratory depression, overdose, seizures during withdrawal, and persistent cognitive impairment.
Wernicke-Korsakoff Syndrome
Specialty: Mental Health and Psychology
Category: Adult
Symptoms:
confusion; memory impairment; ataxia; ophthalmoplegia; nystagmus; hallucinations
Root Cause:
Caused by thiamine (vitamin B1) deficiency, often due to chronic alcohol use, malnutrition, or malabsorption.
How it's Diagnosed: videos
Clinical examination, history of alcohol use or malnutrition, and response to thiamine supplementation. MRI may show characteristic brain changes.
Treatment:
Immediate thiamine replacement via intravenous or intramuscular administration, followed by oral supplementation. Alcohol cessation and nutritional support are critical.
Medications:
Thiamine (vitamin B1) is the primary treatment; no specific psychiatric medications are typically required unless comorbid conditions exist.
Prevalence:
How common the health condition is within a specific population.
Estimated to affect 1–2% of the general population; prevalence is higher in those with alcohol dependence.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Chronic alcoholism, malnutrition, gastrointestinal surgeries, and prolonged vomiting.
Prognosis:
The expected outcome or course of the condition over time.
Early treatment can prevent progression; untreated cases lead to permanent cognitive deficits or death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Permanent memory deficits (Korsakoff psychosis), confusion, coma, and death if untreated.
Delirium, Dementia, and Amnesia in Emergency Medicine
Specialty: Mental Health and Psychology
Category: Emergency
Symptoms:
confusion; disorientation; memory impairment; inattention; altered mental status; hallucinations; agitation; withdrawal
Root Cause:
Acute brain dysfunction often caused by underlying medical issues, such as infections, metabolic imbalances, head trauma, intoxication, or withdrawal.
How it's Diagnosed: videos
Clinical assessment including patient history, mental status exams (e.g., CAM for delirium), physical exams, imaging studies (CT or MRI), and lab tests to identify underlying causes.
Treatment:
Identify and treat the underlying cause (e.g., infections, dehydration, hypoxia), supportive care, and symptomatic treatment (e.g., antipsychotics for agitation).
Medications:
Medications include antipsychotics (e.g., haloperidol or olanzapine ), benzodiazepines for withdrawal-related causes, and cholinesterase inhibitors for dementia management.
Prevalence:
How common the health condition is within a specific population.
Delirium affects 10-30% of hospitalized patients, particularly in the elderly. Dementia affects 5-8% of individuals over 60 globally.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Advanced age, pre-existing cognitive impairment, substance use, infections, polypharmacy, hospitalization, or major surgery.
Prognosis:
The expected outcome or course of the condition over time.
Varies; delirium is often reversible if the cause is treated, but dementia typically progresses chronically. Amnesia prognosis depends on etiology (e.g., head trauma, substance-related causes).
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Falls, prolonged hospitalization, worsening of underlying conditions, or progression to chronic cognitive impairment.
Ganser Syndrome
Specialty: Mental Health and Psychology
Category: Psychiatric Disorders
Sub-category: Dissociative Disorders
Symptoms:
approximate answers; confusion; amnesia; hallucinations; dissociation
Root Cause:
Rare dissociative disorder often linked to extreme stress, trauma, or underlying psychiatric illness.
How it's Diagnosed: videos
Clinical evaluation and exclusion of organic causes. It is often identified by characteristic symptoms like nonsensical or approximate answers.
Treatment:
Psychotherapy (e.g., trauma-focused therapy) and supportive care. Treat any underlying psychiatric or medical condition.
Medications:
No specific medications; treatment focuses on managing symptoms with antidepressants or antipsychotics as needed.
Prevalence:
How common the health condition is within a specific population.
Extremely rare, with most cases reported in individuals under extreme stress or in forensic settings.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Severe stress, trauma, personality disorders, or legal pressure.
Prognosis:
The expected outcome or course of the condition over time.
Symptoms often resolve with appropriate psychological support and stress relief.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Misdiagnosis, prolonged distress, or functional impairment.
Selective Serotonin Reuptake Inhibitor (SSRI) Toxicity
Specialty: Mental Health and Psychology
Category: Emergency
Sub-category: Medication Toxicity
Symptoms:
agitation; confusion; tremors; hyperreflexia; tachycardia; sweating; nausea; diarrhea; seizures; hyperthermia
Root Cause:
Excessive serotonin activity in the central nervous system due to overdose or interaction with other serotonergic drugs.
How it's Diagnosed: videos
Clinical diagnosis based on history of SSRI use and presentation of symptoms consistent with serotonin syndrome. Rule out other causes like infection or withdrawal.
Treatment:
Discontinuation of the SSRI, supportive care (hydration, cooling measures for hyperthermia), benzodiazepines for agitation, and administration of cyproheptadine (a serotonin antagonist) in severe cases.
Medications:
Cyproheptadine (antihistamine with serotonin antagonist properties), benzodiazepines for sedation, and IV fluids for stabilization.
Prevalence:
How common the health condition is within a specific population.
Incidence is relatively rare but can occur in up to 15% of SSRI overdoses.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Polypharmacy involving serotonergic drugs, overdose, or genetic susceptibility to altered serotonin metabolism.
Prognosis:
The expected outcome or course of the condition over time.
Good if treated promptly; untreated severe cases can lead to life-threatening complications like seizures or organ failure.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Seizures, rhabdomyolysis, renal failure, and cardiovascular collapse in severe cases.
Alzheimer Disease in Down Syndrome
Specialty: Mental Health and Psychology
Category: Geriatric
Symptoms:
early-onset memory loss; difficulty in daily functioning; behavioral changes; confusion; seizures in later stages
Root Cause:
Overexpression of amyloid precursor protein due to the extra copy of chromosome 21, leading to accelerated accumulation of amyloid plaques.
How it's Diagnosed: videos
Cognitive evaluations tailored for intellectual disability, neuroimaging (MRI, PET scans), and medical history.
Treatment:
Same as Alzheimer Disease; additional focus on managing the unique needs of individuals with Down Syndrome.
Medications:
Donepezil and Memantine are commonly prescribed but may require dosage adjustments.
Prevalence:
How common the health condition is within a specific population.
Affects up to 50% of individuals with Down Syndrome by age 60.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Genetic predisposition due to trisomy 21, increasing age.
Prognosis:
The expected outcome or course of the condition over time.
Generally worse than typical Alzheimer's due to earlier onset and associated health conditions.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Faster disease progression, epilepsy, and earlier functional decline.
Vascular Dementia
Specialty: Mental Health and Psychology
Category: Geriatric
Symptoms:
memory loss; confusion; difficulty concentrating; mood changes; slowed thinking; difficulty with planning and organization
Root Cause:
Reduced blood flow to the brain due to stroke, small vessel disease, or other vascular conditions leading to brain damage.
How it's Diagnosed: videos
Neuropsychological testing, brain imaging (MRI, CT), medical history, and assessment of vascular risk factors.
Treatment:
Managing vascular risk factors (e.g., blood pressure, cholesterol), cognitive rehabilitation, and supportive therapies.
Medications:
Antihypertensives (e.g., ACE inhibitors), antiplatelet drugs (e.g., Aspirin ), and sometimes cholinesterase inhibitors or Memantine for cognitive symptoms.
Prevalence:
How common the health condition is within a specific population.
Second most common type of dementia, accounting for 10-20% of dementia cases.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Hypertension, diabetes, smoking, atrial fibrillation, and history of stroke or heart disease.
Prognosis:
The expected outcome or course of the condition over time.
Progressive condition; life expectancy varies based on severity and comorbid conditions.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Recurrent strokes, increased disability, and caregiver burden.
Bacterial Sepsis
Specialty: Infectious Diseases
Category: Bacterial Infections
Symptoms:
fever; chills; rapid heart rate; rapid breathing; low blood pressure; confusion; reduced urine output
Root Cause:
Systemic inflammatory response caused by bacterial infection in the blood, often due to Gram-positive (e.g., Staphylococcus aureus) or Gram-negative (e.g., Escherichia coli) bacteria.
How it's Diagnosed: videos
Blood cultures, imaging studies to locate infection, complete blood count, and markers like procalcitonin or C-reactive protein.
Treatment:
Prompt administration of broad-spectrum antibiotics, source control (e.g., draining abscess), and supportive care in intensive care.
Medications:
Broad-spectrum antibiotics such as piperacillin-tazobactam (penicillin/beta-lactamase inhibitor) or carbapenems. Tailored therapy based on culture results.
Prevalence:
How common the health condition is within a specific population.
Significant; affects millions globally, with high mortality in severe cases.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Immunosuppression, invasive procedures, chronic illnesses (e.g., diabetes), or hospital-acquired infections.
Prognosis:
The expected outcome or course of the condition over time.
Varies; early treatment improves outcomes. Severe cases can lead to multi-organ failure and death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Septic shock, multi-organ dysfunction, and long-term disability.
Listeria Monocytogenes Infection (Listeriosis)
Specialty: Infectious Diseases
Category: Bacterial Infections
Symptoms:
fever; muscle aches; nausea; diarrhea; stiff neck; confusion; loss of balance; convulsions
Root Cause:
Caused by the bacterium Listeria monocytogenes, typically through contaminated food. It invades host cells and can spread systemically, particularly affecting immunocompromised individuals.
How it's Diagnosed: videos
Blood cultures, cerebrospinal fluid (CSF) analysis, or stool cultures; polymerase chain reaction (PCR) testing for Listeria DNA.
Treatment:
Antibiotic therapy, supportive care for severe infections, and prevention through proper food handling.
Medications:
Ampicillin (penicillin-class antibiotic) is the first-line treatment; in cases of penicillin allergy, trimethoprim-sulfamethoxazole (sulfonamide-class antibiotic) can be used. For severe cases, combination therapy with gentamicin (aminoglycoside antibiotic) is recommended.
Prevalence:
How common the health condition is within a specific population.
Rare, with approximately 0.1–10 cases per million people annually; more common in pregnant women, neonates, the elderly, and immunocompromised individuals.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Consuming contaminated food (e.g., unpasteurized dairy, processed meats), weakened immune system, pregnancy, newborn status.
Prognosis:
The expected outcome or course of the condition over time.
Good with prompt treatment; however, untreated severe cases can lead to high mortality rates, especially in neonates and immunocompromised patients.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Meningitis, sepsis, miscarriage or stillbirth in pregnant women, encephalitis, and death in severe cases.
Meningococcemia
Specialty: Infectious Diseases
Category: Bacterial Infections
Sub-category: Systemic Infections
Symptoms:
fever; rash; cold extremities; rapid breathing; confusion; nausea; vomiting
Root Cause:
Caused by Neisseria meningitidis entering the bloodstream, leading to widespread vascular inflammation and potential sepsis.
How it's Diagnosed: videos
Blood cultures, CSF cultures, Gram stain, or PCR for Neisseria meningitidis DNA.
Treatment:
Immediate antibiotic therapy and supportive care, including fluid resuscitation and management of shock.
Medications:
Ceftriaxone or cefotaxime (cephalosporin-class antibiotics); penicillin G may also be used. Prophylaxis with rifampin (rifamycin-class antibiotic) or ciprofloxacin (fluoroquinolone-class antibiotic) for close contacts.
Prevalence:
How common the health condition is within a specific population.
Sporadic and epidemic cases worldwide; incidence varies widely depending on region and vaccination rates.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Crowded living conditions, immune deficiencies, close contact with infected individuals.
Prognosis:
The expected outcome or course of the condition over time.
Life-threatening without treatment; mortality can be reduced with prompt therapy, but survivors may face long-term complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Septic shock, disseminated intravascular coagulation (DIC), limb loss due to necrosis, neurological damage.
Rocky Mountain Spotted Fever (RMSF)
Specialty: Infectious Diseases
Category: Bacterial Infections
Sub-category: Rickettsial Diseases
Symptoms:
fever; headache; rash (starting on wrists and ankles); muscle aches; nausea; vomiting; confusion
Root Cause:
Caused by infection with Rickettsia rickettsii, transmitted by tick bites.
How it's Diagnosed: videos
Clinical presentation, serological testing, and PCR.
Treatment:
Immediate administration of doxycycline; treatment is started empirically based on suspicion.
Medications:
Doxycycline (tetracycline antibiotic); chloramphenicol (alternative for pregnant women in certain cases).
Prevalence:
How common the health condition is within a specific population.
Endemic in the Americas, particularly in the southeastern United States.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Exposure to tick-infested areas, lack of protective clothing during outdoor activities.
Prognosis:
The expected outcome or course of the condition over time.
Good with early treatment; delayed diagnosis can lead to severe complications or death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Multi-organ failure, disseminated intravascular coagulation (DIC), or long-term neurological deficits.
Cysticercosis (Pork Tapeworm Infection)
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
seizures; headaches; confusion; intracranial hypertension; vision changes; nausea; vomiting
Root Cause:
Infection with Taenia solium larvae, often acquired through ingestion of food or water contaminated with eggs of the pork tapeworm.
How it's Diagnosed: videos
MRI or CT scans to detect cysts in the brain, serologic tests (enzyme-linked immunoelectrotransfer blot), and patient history of exposure.
Treatment:
Combination of antiparasitic therapy, corticosteroids, and symptomatic treatment. Surgery may be required in some cases to remove cysts or relieve pressure.
Medications:
Antiparasitic medications include albendazole or praziquantel (antihelminthic drugs). Corticosteroids such as dexamethasone or prednisone are used to control inflammation. Antiepileptic drugs (e.g., phenytoin , carbamazepine ) are prescribed to manage seizures.
Prevalence:
How common the health condition is within a specific population.
Endemic in developing countries, particularly in areas with poor sanitation and where pigs are raised. Prevalence varies widely but is common in parts of Latin America, Africa, and Asia.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Consumption of undercooked pork, poor sanitation, exposure to feces contaminated with Taenia solium eggs.
Prognosis:
The expected outcome or course of the condition over time.
With prompt diagnosis and treatment, prognosis is generally good, although chronic neurological effects may persist in severe cases.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Hydrocephalus, chronic seizures, encephalitis, and death in severe untreated cases.
Eastern Equine Encephalitis (EEE)
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
high fever; stiff neck; severe headache; vomiting; drowsiness; confusion; seizures; coma
Root Cause:
Infection caused by the Eastern Equine Encephalitis virus (EEEV), transmitted through the bite of an infected mosquito.
How it's Diagnosed: videos
Diagnosis is made through serologic tests (detection of IgM antibodies in cerebrospinal fluid or serum), PCR, or viral isolation from samples.
Treatment:
Supportive care, including respiratory support, anticonvulsants for seizures, and fluids for dehydration. No specific antiviral treatment is available.
Medications:
No direct antiviral medications; symptomatic treatments include anticonvulsants (e.g., levetiracetam or valproic acid) and medications to manage complications such as swelling in the brain (e.g., mannitol or corticosteroids).
Prevalence:
How common the health condition is within a specific population.
Rare but more common in the eastern United States, primarily in areas with wetland habitats. Annual cases are low, typically fewer than 10 per year in the U.S.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Living in or traveling to areas with high mosquito populations, outdoor exposure without protective measures.
Prognosis:
The expected outcome or course of the condition over time.
High mortality rate (approximately 30%); survivors often have long-term neurological sequelae.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Severe neurological damage, paralysis, intellectual disability, and death.
Japanese Encephalitis
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
fever; headache; nausea and vomiting; seizures; confusion; movement disorders; coma in severe cases
Root Cause:
Viral infection caused by the Japanese encephalitis virus (JEV), transmitted by Culex mosquitoes, leading to inflammation of the brain.
How it's Diagnosed: videos
Diagnosed through serological tests like IgM antibody capture ELISA (MAC-ELISA) in CSF or blood samples, and imaging (MRI).
Treatment:
Supportive care to manage symptoms, such as antipyretics for fever and anticonvulsants for seizures. No specific antiviral treatment.
Medications:
Supportive medications include anticonvulsants (e.g., phenytoin or levetiracetam ) and antipyretics (e.g., acetaminophen ). These are symptom-relieving drugs.
Prevalence:
How common the health condition is within a specific population.
Endemic in parts of Asia and the Western Pacific; affects approximately 50,000–100,000 people annually.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Living in or traveling to endemic areas, exposure to mosquito bites, and lack of vaccination.
Prognosis:
The expected outcome or course of the condition over time.
Mortality rate is 20–30%, and 30–50% of survivors have significant neurological or psychiatric sequelae.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Seizures, permanent neurological disabilities, movement disorders, and behavioral issues.
Venezuelan Equine Encephalitis
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
fever; headache; nausea; vomiting; seizures; confusion; weakness; photophobia
Root Cause:
Caused by the Venezuelan equine encephalitis virus, transmitted by mosquitoes, leading to inflammation of the brain.
How it's Diagnosed: videos
Serologic tests for viral antibodies (e.g., ELISA), PCR for viral RNA, and CSF analysis.
Treatment:
Supportive care (e.g., hydration, antipyretics, and seizure control); no specific antiviral treatment available.
Medications:
Antipyretics (e.g., acetaminophen for fever); anticonvulsants (e.g., phenytoin or valproic acid for seizures).
Prevalence:
How common the health condition is within a specific population.
Sporadic outbreaks in Central and South America; rare in humans, more common in equines.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Living or working in endemic areas, exposure to mosquitoes, and outdoor activities.
Prognosis:
The expected outcome or course of the condition over time.
Most recover fully, but severe cases may lead to neurological deficits or death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Long-term neurological sequelae (e.g., cognitive deficits, epilepsy), and in severe cases, death.
Viral Encephalitis
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
fever; headache; confusion; seizures; nausea; vomiting; altered mental status; photophobia
Root Cause:
Brain inflammation caused by viral infections (e.g., herpes simplex virus, arboviruses), leading to neuronal damage.
How it's Diagnosed: videos
Clinical evaluation, CSF analysis, PCR for viral DNA/RNA, and neuroimaging (e.g., MRI).
Treatment:
Antiviral therapy for specific viruses (e.g., acyclovir for herpes simplex virus); supportive care for other viral causes.
Medications:
Acyclovir (for herpes simplex); antipyretics (e.g., ibuprofen for fever); anticonvulsants (e.g., levetiracetam for seizures).
Prevalence:
How common the health condition is within a specific population.
Varies; common in areas with high mosquito-borne virus activity or sporadic herpes outbreaks.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Immunosuppression, unvaccinated status, and mosquito exposure.
Prognosis:
The expected outcome or course of the condition over time.
Depends on the cause and severity; early treatment improves outcomes, but severe cases may result in lasting deficits.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Long-term neurological damage, seizures, cognitive deficits, and death if untreated.
West Nile Virus (WNV) Infection and Encephalitis (WNE)
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
fever; headache; muscle weakness; fatigue; seizures; confusion; stiff neck
Root Cause:
Viral infection transmitted by mosquitoes, leading to inflammation of the brain and nervous system.
How it's Diagnosed: videos
PCR or serology for WNV in blood or CSF; neuroimaging may reveal inflammation.
Treatment:
Supportive care (hydration, pain management, seizure control); no specific antiviral therapy.
Medications:
Analgesics for pain relief (e.g., acetaminophen ); anticonvulsants (e.g., levetiracetam for seizures).
Prevalence:
How common the health condition is within a specific population.
Found in many parts of the world, especially during mosquito season.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Outdoor activities, lack of mosquito control, immunosuppression.
Prognosis:
The expected outcome or course of the condition over time.
Most recover, but severe cases may result in neurological deficits or death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic fatigue, cognitive impairment, and long-term neurological deficits in severe cases.
Central Nervous System Lymphoma in HIV
Specialty: Infectious Diseases
Category: Central Nervous System Complications in HIV
Symptoms:
headache; seizures; confusion; focal neurological deficits; behavioral changes; vision problems
Root Cause:
Epstein-Barr Virus (EBV)-associated malignancy that occurs due to severe immunosuppression in HIV patients, leading to unregulated B-cell proliferation.
How it's Diagnosed: videos
MRI or CT scan showing mass lesions, CSF cytology for malignant cells, and EBV DNA detection in CSF. Brain biopsy may be needed for definitive diagnosis.
Treatment:
High-dose methotrexate-based chemotherapy combined with ART; corticosteroids to reduce cerebral edema; radiation therapy in selected cases.
Medications:
High-dose methotrexate (antimetabolite chemotherapy), rituximab (monoclonal antibody), and corticosteroids such as dexamethasone (anti-inflammatory).
Prevalence:
How common the health condition is within a specific population.
Occurs in approximately 3–5% of HIV patients with advanced immunosuppression.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
CD4 count <50 cells/mm³, untreated or poorly controlled HIV, and EBV infection.
Prognosis:
The expected outcome or course of the condition over time.
Poor without treatment; survival improves with ART and aggressive lymphoma treatment but remains limited due to recurrence and systemic complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Intracranial pressure, seizures, cognitive impairment, and recurrence of lymphoma.
CNS Toxoplasmosis in HIV
Specialty: Infectious Diseases
Category: Central Nervous System Complications in HIV
Symptoms:
headache; seizures; confusion; fever; focal neurological deficits; lethargy
Root Cause:
Reactivation of latent infection by Toxoplasma gondii due to profound immunosuppression.
How it's Diagnosed: videos
Brain imaging (MRI or CT) showing ring-enhancing lesions, positive Toxoplasma serology (IgG), and CSF PCR for Toxoplasma gondii DNA.
Treatment:
Combination of pyrimethamine, sulfadiazine, and leucovorin; ART to restore immune function.
Medications:
Pyrimethamine (antiparasitic), sulfadiazine (antibiotic), leucovorin (folinic acid to reduce bone marrow toxicity).
Prevalence:
How common the health condition is within a specific population.
Occurs in 10–30% of HIV patients with CD4 counts <100 cells/mm³, especially in those not receiving prophylaxis.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Advanced HIV, exposure to Toxoplasma (e.g., undercooked meat, cat feces), and lack of prophylactic treatment.
Prognosis:
The expected outcome or course of the condition over time.
Good if treated early; untreated cases have high mortality. Residual neurological deficits may occur.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Persistent neurological deficits, seizures, or progression to coma in severe cases.
African Trypanosomiasis (Sleeping Sickness)
Specialty: Infectious Diseases
Category: Parasitic Infections
Symptoms:
fever; headache; joint pain; itching; swelling of lymph nodes; confusion; personality changes; severe sleep disturbances; neurological impairments
Root Cause:
Caused by the protozoan Trypanosoma brucei species transmitted via tsetse fly bites, leading to systemic and central nervous system infection.
How it's Diagnosed: videos
Blood smear microscopy, serological tests, lumbar puncture to detect trypanosomes in cerebrospinal fluid (CSF).
Treatment:
Antiparasitic therapy, depending on the disease stage.
Medications:
Pentamidine (for early-stage T. brucei gambiense), suramin (for early-stage T. brucei rhodesiense), melarsoprol (for late-stage CNS involvement), eflornithine , or fexinidazole (recently approved oral treatment).
Prevalence:
How common the health condition is within a specific population.
Endemic to sub-Saharan Africa, with periodic outbreaks. Cases have decreased due to control programs.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Living in or traveling to endemic areas, exposure to tsetse fly habitats, and lack of protective measures.
Prognosis:
The expected outcome or course of the condition over time.
Early treatment leads to recovery; untreated cases are fatal.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Neurological damage, seizures, coma, and death in advanced stages.
Toxoplasmosis (Organism-Specific Therapy)
Specialty: Infectious Diseases
Category: Parasitic Infections
Symptoms:
severe headaches; fever; confusion; seizures; blurry vision
Root Cause:
Severe infection by Toxoplasma gondii, often in immunocompromised patients such as those with HIV/AIDS.
How it's Diagnosed: videos
Blood tests for antibodies, imaging for CNS involvement, and clinical presentation.
Treatment:
High-dose antiparasitic and antibiotic combination tailored to the severity of infection.
Medications:
High-dose pyrimethamine (antimalarial) and sulfadiazine (antibiotic), along with leucovorin to prevent folate deficiency.
Prevalence:
How common the health condition is within a specific population.
Higher incidence in immunocompromised populations; overall prevalence similar to toxoplasmosis.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Weakened immune system, HIV/AIDS, organ transplantation.
Prognosis:
The expected outcome or course of the condition over time.
Guarded in immunocompromised individuals; depends on timely diagnosis and treatment.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Neurological damage, vision loss, and recurrence in untreated cases.
Lymphocytic Choriomeningitis Virus (LCMV) Infection
Specialty: Infectious Diseases
Category: COVID-19 Reinfections
Symptoms:
fever; malaise; headache; nausea; vomiting; stiff neck; photophobia; confusion
Root Cause:
Infection caused by the LCMV, a rodent-borne arenavirus, leading to aseptic meningitis or meningoencephalitis in severe cases.
How it's Diagnosed: videos
Detection of LCMV-specific antibodies in cerebrospinal fluid (CSF) or blood, PCR for viral RNA, and history of exposure to rodents.
Treatment:
Supportive care, including pain management, anti-inflammatory medications, and fluid therapy; antivirals like ribavirin may be used experimentally.
Medications:
No FDA-approved specific treatment; ribavirin (antiviral) is sometimes used off-label for severe cases.
Prevalence:
How common the health condition is within a specific population.
Rare; exposure often occurs via infected rodents or their excreta, with occasional outbreaks in specific regions.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Exposure to rodents, handling pet hamsters, and living in environments with poor rodent control.
Prognosis:
The expected outcome or course of the condition over time.
Generally good with supportive care; severe cases can result in neurological complications or, rarely, death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Neurological deficits, hydrocephalus, hearing loss, and miscarriage during pregnancy.
Rabies
Specialty: Infectious Diseases
Category: COVID-19 Reinfections
Symptoms:
fever; headache; agitation; hydrophobia (fear of water); paralysis; confusion; delirium; seizures
Root Cause:
Rabies is caused by the rabies virus, which attacks the nervous system, leading to encephalitis and potentially fatal encephalopathy.
How it's Diagnosed: videos
Diagnosis is confirmed by laboratory tests, including PCR, antibody detection, or brain biopsy.
Treatment:
Once symptoms appear, rabies is almost universally fatal. However, post-exposure prophylaxis (PEP) with a rabies vaccine and immunoglobulin can prevent infection if administered promptly after exposure.
Medications:
Rabies vaccine and rabies immunoglobulin (RIG) for post-exposure prophylaxis, classified as immunizations.
Prevalence:
How common the health condition is within a specific population.
Rabies remains a significant issue in developing countries, particularly in Asia and Africa, due to inadequate vaccination in animals.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Animal bites or scratches from infected animals (typically dogs, bats, raccoons).
Prognosis:
The expected outcome or course of the condition over time.
Without treatment, rabies is nearly always fatal after symptoms appear. Early administration of PEP is highly effective.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Once clinical symptoms occur, complications include coma, paralysis, and death.