Background

Comprehensive Symptom Navigator™

Your health assistant, simplified.

Disclaimer: This is just an assistant. It should not be used for diagnosing patients without a doctor's discretion.

Symptoms:

Number of Conditions: 255

Peptic Ulcers

Specialty: Internal Medicine

Category: Digestive and Gastrointestinal Conditions

Symptoms:
burning stomach pain; bloating; nausea; vomiting; dark or tarry stools; fatigue (from anemia)

Root Cause:
Erosion of the stomach or duodenal lining, often due to Helicobacter pylori infection or long-term NSAID use.

How it's Diagnosed: videos
Upper endoscopy, H. pylori testing (breath, stool, or biopsy).

Treatment:
Antibiotics for H. pylori, acid suppression therapy, lifestyle changes.

Medications:
PPIs (e.g., omeprazole ), H2 receptor blockers (e.g., ranitidine), antibiotics (e.g., amoxicillin and clarithromycin for H. pylori).

Prevalence: How common the health condition is within a specific population.
Affects about 5–10% of the population at some point in life.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
H. pylori infection, NSAID use, smoking, stress, alcohol consumption.

Prognosis: The expected outcome or course of the condition over time.
Good with treatment; recurrence possible if underlying causes persist.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Bleeding, perforation, gastric obstruction, increased cancer risk.

Diarrhea

Specialty: Internal Medicine

Category: Digestive and Gastrointestinal Conditions

Symptoms:
frequent, loose stools; abdominal cramps; nausea; dehydration; fever (if infectious)

Root Cause:
Increased stool water content due to infections, food intolerances, medications, or conditions like IBS.

How it's Diagnosed: videos
Clinical history; stool tests for infectious causes; colonoscopy for chronic cases.

Treatment:
Hydration, dietary adjustments, medications based on the cause.

Medications:
Antidiarrheals (e.g., loperamide ), antibiotics for bacterial infections, probiotics for gut health.

Prevalence: How common the health condition is within a specific population.
Common; acute cases occur in nearly everyone at some point.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Contaminated food or water, infections, antibiotic use, chronic conditions.

Prognosis: The expected outcome or course of the condition over time.
Excellent for acute cases; chronic diarrhea depends on underlying cause.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Dehydration, electrolyte imbalances, malnutrition.

Diverticulitis

Specialty: Infectious Diseases

Category: Gastrointestinal Tract and Intra-abdominal Infections

Symptoms:
lower left abdominal pain; fever; nausea; constipation or diarrhea; bloating

Root Cause:
Inflammation or infection of diverticula (small pouches in the colon wall) often caused by fecal impaction or micro-perforations.

How it's Diagnosed: videos
CT scan of the abdomen, blood tests (elevated white blood cell count, markers of inflammation like CRP), and, in some cases, colonoscopy (not during acute phase).

Treatment:
Antibiotics for mild to moderate cases, clear liquid diet during acute episodes, and surgery for complications like abscess, perforation, or obstruction.

Medications:
Ciprofloxacin (fluoroquinolone antibiotic) and Metronidazole (nitroimidazole antibiotic) often used together; Amoxicillin-clavulanate as an alternative.

Prevalence: How common the health condition is within a specific population.
Common, especially in older adults; affects about 35–45% of people over age 60 in Western countries.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Aging, low-fiber diet, obesity, sedentary lifestyle, smoking, and NSAID use.

Prognosis: The expected outcome or course of the condition over time.
Good with prompt treatment; recurrent episodes may lead to chronic complications.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Abscess formation, perforation, peritonitis, fistulas, and bowel obstruction.

Gallbladder Issues (Mild)

Specialty: Internal Medicine

Category: Digestive and Gastrointestinal Conditions

Symptoms:
right upper abdominal pain; nausea; vomiting; indigestion; pain after eating fatty meals

Root Cause:
Gallstones (cholelithiasis) or inflammation (cholecystitis) impairing gallbladder function.

How it's Diagnosed: videos
Ultrasound, liver function tests, HIDA scan.

Treatment:
Dietary modifications, pain management; surgery if recurrent or severe.

Medications:
Analgesics (e.g., acetaminophen ), ursodeoxycholic acid for gallstone dissolution (rarely used).

Prevalence: How common the health condition is within a specific population.
Affects 10–15% of adults; more common in women.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Obesity, high-fat diet, pregnancy, rapid weight loss.

Prognosis: The expected outcome or course of the condition over time.
Good with management; severe cases may require cholecystectomy.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Biliary colic, pancreatitis, bile duct obstruction.

Migraines and Headaches

Specialty: Internal Medicine

Category: Neurological and Mental Health Conditions

Symptoms:
throbbing or pulsating headache; sensitivity to light and sound; nausea; vomiting; aura (visual or sensory disturbances) in some cases

Root Cause:
Thought to involve abnormal brain activity affecting nerve signals, chemicals, and blood vessels.

How it's Diagnosed: videos
Clinical history, symptom patterns, ruling out other causes with imaging if necessary.

Treatment:
Preventive measures, acute treatment during attacks, lifestyle modifications.

Medications:
Triptans (e.g., sumatriptan ), NSAIDs (e.g., ibuprofen ), antiemetics (e.g., metoclopramide ), preventive drugs like beta-blockers (e.g., propranolol ), anticonvulsants (e.g., topiramate ), CGRP inhibitors (e.g., erenumab ).

Prevalence: How common the health condition is within a specific population.
Affects about 12% of the population globally; more common in women.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Stress, hormonal changes, certain foods or drinks, sleep disturbances, family history.

Prognosis: The expected outcome or course of the condition over time.
Manageable; frequency and severity often decrease with treatment and lifestyle changes.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Medication overuse headaches, chronic migraines, reduced quality of life.

Kidney Infections (Pyelonephritis)

Specialty: Internal Medicine

Category: Genitourinary and Reproductive Health

Symptoms:
fever; flank pain; nausea; vomiting; chills; painful urination; cloudy or foul-smelling urine

Root Cause:
Bacterial infection ascending from the bladder to the kidneys.

How it's Diagnosed: videos
Urinalysis, urine culture, imaging (e.g., CT or ultrasound for severe cases).

Treatment:
Antibiotics, hydration, hospitalization in severe cases.

Medications:
Ciprofloxacin , ceftriaxone , trimethoprim-sulfamethoxazole.

Prevalence: How common the health condition is within a specific population.
Affects 1–2% of women annually; less common in men.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
UTIs, kidney stones, diabetes, urinary obstruction.

Prognosis: The expected outcome or course of the condition over time.
Good with prompt treatment.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Sepsis, kidney damage, abscess formation.

Vertigo (e.g., Benign Paroxysmal Positional Vertigo - BPPV)

Specialty: Internal Medicine

Category: Eye, Ear, Nose, and Throat (ENT) Conditions

Symptoms:
spinning sensation; loss of balance; nausea; vomiting; nystagmus (involuntary eye movement)

Root Cause:
Displacement of calcium crystals (otoliths) in the inner ear, affecting balance.

How it's Diagnosed: videos
Dix-Hallpike maneuver, clinical history, imaging (if atypical symptoms).

Treatment:
Repositioning maneuvers (e.g., Epley maneuver), medications for symptom relief in acute episodes.

Medications:
Antihistamines (e.g., meclizine ), benzodiazepines (e.g., diazepam ) for severe episodes.

Prevalence: How common the health condition is within a specific population.
BPPV is the most common cause of peripheral vertigo; affects about 1–2% of the population annually.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Aging, head trauma, vestibular disorders.

Prognosis: The expected outcome or course of the condition over time.
Excellent with proper treatment; symptoms often resolve with repositioning maneuvers.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Falls, persistent imbalance, anxiety about recurrent episodes.

Acute Gastroenteritis

Specialty: Pediatrics

Category: Gastrointestinal Disorders

Sub-category: Infectious and Inflammatory Disorders

Symptoms:
diarrhea; nausea; vomiting; abdominal cramps; fever; dehydration

Root Cause:
Inflammation of the stomach and intestines caused by viral, bacterial, or parasitic infections.

How it's Diagnosed: videos
Clinical history, physical examination, stool tests (to identify causative pathogen), and sometimes blood tests if dehydration or severe infection is suspected.

Treatment:
Rehydration therapy (oral or IV), dietary adjustments, and in some cases, antimicrobial therapy for bacterial or parasitic infections.

Medications:
Antiemetics (e.g., ondansetron ), antidiarrheals (e.g., loperamide ), antibiotics (e.g., azithromycin for bacterial infections like Campylobacter or Shigella), and antiparasitics (e.g., metronidazole for Giardia).

Prevalence: How common the health condition is within a specific population.
Affects millions globally, especially in children under five, with higher prevalence in low-resource settings.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Poor sanitation, contaminated food or water, daycare settings, international travel.

Prognosis: The expected outcome or course of the condition over time.
Generally good with supportive care; most cases resolve in a few days without complications.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Severe dehydration, electrolyte imbalance, malnutrition, hemolytic uremic syndrome (HUS) in some bacterial infections.

Hepatitis (A, B, C, Autoimmune)

Specialty: Pediatrics

Category: Gastrointestinal Disorders

Sub-category: Infectious and Autoimmune Disorders

Symptoms:
jaundice; fatigue; abdominal pain; dark urine; light-colored stool; nausea; vomiting

Root Cause:
Liver inflammation caused by viral infections (Hepatitis A, B, C) or immune-mediated attack on liver cells (Autoimmune Hepatitis).

How it's Diagnosed: videos
Blood tests (liver enzymes, viral serology, autoimmune markers), liver ultrasound, and sometimes liver biopsy.

Treatment:
Hepatitis A

Medications:
Antivirals (e.g., tenofovir , entecavir for Hepatitis B; sofosbuvir , ribavirin for Hepatitis C), corticosteroids (e.g., prednisone for Autoimmune Hepatitis), and immunosuppressants (e.g., azathioprine ).

Prevalence: How common the health condition is within a specific population.
Hepatitis A and B

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Poor hygiene (Hepatitis A), unvaccinated status (Hepatitis B), needle sharing (Hepatitis C), genetic predisposition (Autoimmune Hepatitis).

Prognosis: The expected outcome or course of the condition over time.
Hepatitis A

Complications: Additional problems or conditions that may arise as a result of the original condition.
Chronic liver disease, cirrhosis, hepatocellular carcinoma, liver failure.

Diabetic Ketoacidosis (DKA)

Specialty: Diabetes and Endocrinology

Category: Diabetes Mellitus and Related Disorders

Sub-category: Acute Complications

Symptoms:
excessive thirst; frequent urination; nausea; vomiting; abdominal pain; shortness of breath; fruity-smelling breath; confusion

Root Cause:
Insulin deficiency leads to uncontrolled hyperglycemia, lipolysis, and ketone production, causing metabolic acidosis.

How it's Diagnosed: videos
Blood tests showing high blood glucose, ketonemia, low bicarbonate, and arterial blood pH < 7.3; urine tests for ketones.

Treatment:
Intravenous fluids, insulin therapy, electrolyte replacement (potassium), and treating underlying causes (e.g., infection).

Medications:
Regular insulin administered intravenously to reduce blood glucose and ketone levels.

Prevalence: How common the health condition is within a specific population.
Common in individuals with type 1 diabetes; can occur in type 2 diabetes during severe stress.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Poor diabetes management, infection, trauma, surgery, or missed insulin doses.

Prognosis: The expected outcome or course of the condition over time.
Early treatment leads to recovery; delayed treatment may result in coma or death.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Cerebral edema, hypokalemia, arrhythmias, and death.

Adrenal insufficiency (e.g., Addison’s disease)

Specialty: Pediatrics

Category: Endocrine Disorders

Sub-category: Other Endocrine Issues

Symptoms:
fatigue; weight loss; low blood pressure; hyperpigmentation of the skin; abdominal pain; nausea; vomiting; salt cravings; hypoglycemia

Root Cause:
Insufficient production of cortisol and/or aldosterone by the adrenal glands, often due to autoimmune destruction, infection, or adrenal gland damage.

How it's Diagnosed: videos
Blood tests measuring cortisol and ACTH levels, ACTH stimulation test, electrolyte panels, and imaging studies (e.g., CT or MRI of the adrenal glands).

Treatment:
Hormone replacement therapy, including glucocorticoids (e.g., hydrocortisone) and mineralocorticoids (e.g., fludrocortisone), along with lifestyle adjustments and emergency injectable hydrocortisone for adrenal crises.

Medications:
Hydrocortisone or prednisone (glucocorticoids) replace cortisol; fludrocortisone (a mineralocorticoid) replaces aldosterone. Glucocorticoids are corticosteroids, while fludrocortisone is a mineralocorticoid.

Prevalence: How common the health condition is within a specific population.
Rare, affecting approximately 1 in 10,000 to 20,000 people globally.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Autoimmune conditions (e.g., autoimmune polyendocrine syndrome), family history, infections (e.g., tuberculosis), adrenal gland damage due to trauma or surgery.

Prognosis: The expected outcome or course of the condition over time.
With appropriate treatment, patients can lead normal lives; however, untreated adrenal insufficiency can be life-threatening.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Adrenal crisis (acute life-threatening condition), electrolyte imbalances, hypoglycemia, and increased susceptibility to stress-related illnesses.

Wilms' Tumor (Nephroblastoma)

Specialty: Pediatrics

Category: Hematologic and Oncologic Disorders

Sub-category: Oncologic Conditions

Symptoms:
abdominal mass or swelling; abdominal pain; blood in the urine (hematuria); fever; nausea; loss of appetite; high blood pressure

Root Cause:
Malignant tumor originating from embryonal kidney cells, typically affecting one kidney but occasionally bilateral.

How it's Diagnosed: videos
Imaging studies (ultrasound, CT, MRI), biopsy or surgical removal of the tumor for histopathological examination, and blood/urine tests.

Treatment:
Surgery (nephrectomy), chemotherapy, and in some cases, radiation therapy.

Medications:
Chemotherapy agents include actinomycin D (antitumor antibiotic), vincristine (microtubule inhibitor), and doxorubicin (anthracycline).

Prevalence: How common the health condition is within a specific population.
Occurs in approximately 1 in 10,000 children, most commonly diagnosed in children aged 3 to 4 years.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Genetic syndromes (e.g., WAGR syndrome, Beckwith-Wiedemann syndrome, Denys-Drash syndrome), family history of Wilms' tumor, and certain congenital abnormalities.

Prognosis: The expected outcome or course of the condition over time.
Favorable in most cases; 5-year survival rates exceed 90% with prompt and appropriate treatment.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Complications include metastasis (commonly to the lungs), kidney dysfunction, recurrence, and long-term effects of chemotherapy or radiation.

Concussion and Traumatic Brain Injury (TBI)

Specialty: Emergency and Urgent Care

Category: Trauma and Injuries

Sub-category: Blunt Trauma

Symptoms:
headache; confusion; dizziness; nausea; vomiting; temporary loss of consciousness; difficulty concentrating; memory problems; sleep disturbances; mood changes

Root Cause:
Disruption in normal brain function due to a direct blow, jolt, or penetrating injury to the head causing mechanical damage to brain tissue.

How it's Diagnosed: videos
Clinical evaluation, Glasgow Coma Scale (GCS), neurological exam, imaging studies (CT scan or MRI).

Treatment:
Rest, symptom management, physical and cognitive rehabilitation, and monitoring for complications.

Medications:
Pain relievers (acetaminophen ), anti-nausea medications, and sometimes anticonvulsants (e.g., phenytoin ) or diuretics (e.g., mannitol ) to reduce intracranial pressure.

Prevalence: How common the health condition is within a specific population.
Millions of cases worldwide annually, with mild TBI (concussion) being the most common.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Sports injuries, motor vehicle accidents, falls, and assaults.

Prognosis: The expected outcome or course of the condition over time.
Most mild TBIs resolve with proper care; severe TBIs may result in lasting neurological deficits or disability.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Post-concussion syndrome, chronic traumatic encephalopathy (CTE), seizures, and long-term cognitive or psychological impairments.

Unstable Angina

Specialty: Cardiovascular

Category: Heart Diseases

Sub-category: Coronary Artery Disease (CAD)

Symptoms:
sudden and worsening chest pain; pain at rest or with minimal exertion; shortness of breath; nausea; sweating

Root Cause:
Acute reduction in blood flow to the heart due to ruptured plaque or clot formation in the coronary arteries.

How it's Diagnosed: videos
Electrocardiogram (ECG); blood tests for cardiac biomarkers like troponins; coronary angiography

Treatment:
Immediate medical intervention to restore blood flow, often involving antiplatelet therapy and coronary interventions.

Medications:
Medications include antiplatelet drugs (e.g., aspirin , clopidogrel ), anticoagulants (e.g., heparin , enoxaparin ), beta-blockers (e.g., metoprolol ), nitrates (e.g., nitroglycerin ), and statins (e.g., atorvastatin ).

Prevalence: How common the health condition is within a specific population.
Affects individuals with existing coronary artery disease; a precursor to myocardial infarction.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Advanced atherosclerosis; smoking; high blood pressure; high cholesterol; diabetes; obesity; stress

Prognosis: The expected outcome or course of the condition over time.
High risk of myocardial infarction; requires prompt and aggressive treatment.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Heart attack; arrhythmias; sudden cardiac death

Appendicitis

Specialty: Gastrointestinal

Category: General and Miscellaneous GI Conditions

Sub-category: Abdominal Pain and Disorders

Symptoms:
sudden pain in the lower right abdomen; nausea; vomiting; loss of appetite; fever; constipation or diarrhea

Root Cause:
Inflammation of the appendix, often due to obstruction of the appendiceal lumen by fecaliths, lymphoid hyperplasia, or other blockages.

How it's Diagnosed: videos
Clinical evaluation of symptoms, imaging (ultrasound or CT scan), and blood tests showing elevated white blood cell count and inflammatory markers.

Treatment:
Surgical removal of the appendix (appendectomy) is the standard treatment, sometimes preceded by antibiotics in uncomplicated cases.

Medications:
Antibiotics such as ceftriaxone or metronidazole are prescribed preoperatively and postoperatively in some cases to manage or prevent infection.

Prevalence: How common the health condition is within a specific population.
Affects approximately 7% of the population, most commonly in individuals aged 10-30 years.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Family history, high-fat/low-fiber diets, and gastrointestinal infections.

Prognosis: The expected outcome or course of the condition over time.
Excellent with timely diagnosis and treatment; recovery is typically quick following surgery.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Perforation of the appendix, peritonitis, abscess formation, and sepsis in untreated or delayed cases.

Cholecystitis

Specialty: Emergency and Urgent Care

Category: Gastrointestinal Emergencies

Sub-category: Acute Abdominal Pain

Symptoms:
right upper quadrant abdominal pain; nausea; vomiting; fever; pain radiating to the shoulder or back; tenderness in the right upper quadrant

Root Cause:
Inflammation of the gallbladder, usually due to obstruction of the cystic duct by gallstones.

How it's Diagnosed: videos
Clinical examination, abdominal ultrasound, HIDA scan, and elevated inflammatory markers (WBC, CRP).

Treatment:
Fasting (NPO), intravenous fluids, pain control, antibiotics, and cholecystectomy (surgical removal of the gallbladder).

Medications:
Broad-spectrum antibiotics such as piperacillin-tazobactam (penicillin class) or ceftriaxone with metronidazole are commonly prescribed. NSAIDs or opioids for pain management.

Prevalence: How common the health condition is within a specific population.
Affects about 10-15% of the adult population, with acute cholecystitis being a complication in a smaller proportion.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Female gender, obesity, pregnancy, age over 40, rapid weight loss, high-fat diet.

Prognosis: The expected outcome or course of the condition over time.
Good with prompt treatment; untreated cases can lead to severe complications.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Gallbladder rupture, peritonitis, sepsis, emphysematous cholecystitis.

Pancreatitis

Specialty: Emergency and Urgent Care

Category: Gastrointestinal Emergencies

Sub-category: Acute Abdominal Pain

Symptoms:
severe upper abdominal pain; pain radiating to the back; nausea; vomiting; fever; abdominal tenderness; jaundice in some cases

Root Cause:
Inflammation of the pancreas due to gallstones, alcohol use, or other factors like hypertriglyceridemia or trauma.

How it's Diagnosed: videos
Clinical assessment, elevated serum amylase and lipase levels, abdominal ultrasound, or CT scan.

Treatment:
Supportive care with fasting (NPO), IV fluids, pain control, and treating the underlying cause (e.g., gallstone removal). Severe cases may require intensive care or surgical intervention.

Medications:
Analgesics such as morphine (opioid) or NSAIDs for pain; antibiotics only in cases of infected pancreatic necrosis.

Prevalence: How common the health condition is within a specific population.
About 50 cases per 100,000 annually in developed countries.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Alcohol abuse, gallstones, high triglycerides, smoking, certain medications.

Prognosis: The expected outcome or course of the condition over time.
Varies; mild cases resolve in days, while severe cases can lead to multi-organ failure.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Pancreatic necrosis, pseudocysts, infection, systemic inflammatory response syndrome (SIRS).

Perforated Viscus

Specialty: Emergency and Urgent Care

Category: Gastrointestinal Emergencies

Sub-category: Acute Abdominal Pain

Symptoms:
sudden severe abdominal pain; rigid abdomen; fever; nausea; vomiting; hypotension; tachycardia

Root Cause:
Perforation of the gastrointestinal tract, leading to leakage of contents into the abdominal cavity and peritonitis. Common causes include peptic ulcers, diverticulitis, or trauma.

How it's Diagnosed: videos
Clinical examination, X-ray or CT showing free air under the diaphragm (pneumoperitoneum), and blood tests for infection markers.

Treatment:
Emergency surgery to repair the perforation, IV antibiotics, and supportive care.

Medications:
Broad-spectrum antibiotics like ceftriaxone with metronidazole or piperacillin-tazobactam to manage peritonitis. Pain relief with opioids.

Prevalence: How common the health condition is within a specific population.
Rare but life-threatening, particularly in patients with peptic ulcers or diverticulitis.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
NSAID use, corticosteroids, smoking, alcohol use, peptic ulcer disease, trauma.

Prognosis: The expected outcome or course of the condition over time.
Depends on timely intervention; high mortality without treatment.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Sepsis, multi-organ failure, death.

Hernias (Incarcerated, Strangulated)

Specialty: Emergency and Urgent Care

Category: Gastrointestinal Emergencies

Sub-category: Other GI Conditions

Symptoms:
localized pain or tenderness at the hernia site; nausea; vomiting; abdominal distension; redness or discoloration over the hernia; inability to pass stool or gas

Root Cause:
A portion of an organ, typically the intestine, becomes trapped in the hernia sac, compromising blood flow (strangulated) or causing obstruction without blood flow compromise (incarcerated).

How it's Diagnosed: videos
Physical examination, imaging studies such as ultrasound or CT scan, and observation of symptoms like persistent pain and obstruction signs.

Treatment:
Emergent surgical intervention to release the trapped organ and repair the hernia; in severe cases, resection of necrotic tissue may be required.

Medications:
Pain management with opioids or NSAIDs, and prophylactic antibiotics like cefazolin (a first-generation cephalosporin) to reduce infection risk.

Prevalence: How common the health condition is within a specific population.
Incarcerated hernias are relatively common, with about 10-15% of hernias progressing to incarceration; strangulated hernias occur in approximately 1-3% of cases.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Older age, male gender, obesity, chronic coughing or straining, history of previous hernias, heavy lifting.

Prognosis: The expected outcome or course of the condition over time.
Good with timely surgical intervention; delayed treatment can lead to bowel necrosis, sepsis, and increased mortality.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Bowel obstruction, ischemia, necrosis, perforation, and sepsis.

Mesenteric Ischemia

Specialty: Emergency and Urgent Care

Category: Gastrointestinal Emergencies

Sub-category: Vascular GI Conditions

Symptoms:
sudden severe abdominal pain; nausea; vomiting; diarrhea; blood in stool; abdominal distension

Root Cause:
Reduced or completely obstructed blood flow to the intestines due to arterial embolism, arterial thrombosis, or venous thrombosis.

How it's Diagnosed: videos
Clinical history and physical exam, blood tests (elevated lactate levels), imaging studies (CT angiography is the gold standard).

Treatment:
Immediate resuscitation, anticoagulation (e.g., heparin), thrombolysis, and surgical intervention to remove occlusion or resect necrotic bowel.

Medications:
Anticoagulants like heparin (unfractionated or low-molecular-weight), thrombolytics like alteplase (tissue plasminogen activator), and vasodilators like papaverine (to improve blood flow).

Prevalence: How common the health condition is within a specific population.
Rare but life-threatening, affecting approximately 0.1-0.2% of hospital admissions; more common in elderly individuals.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Atrial fibrillation, heart failure, atherosclerosis, recent abdominal surgery, hypercoagulable states.

Prognosis: The expected outcome or course of the condition over time.
Poor if not treated promptly; mortality rates can exceed 70% for acute cases with bowel necrosis.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Bowel infarction, perforation, sepsis, multi-organ failure.

Diabetic ketoacidosis (DKA)

Specialty: Emergency and Urgent Care

Category: Endocrine and Metabolic Emergencies

Sub-category: Diabetes-Related Emergencies

Symptoms:
nausea; vomiting; abdominal pain; rapid breathing; fruity-scented breath; confusion; excessive thirst; frequent urination

Root Cause:
DKA occurs due to insufficient insulin, leading to uncontrolled hyperglycemia, ketone production, and metabolic acidosis.

How it's Diagnosed: videos
Clinical evaluation, laboratory tests showing hyperglycemia (blood glucose >250 mg/dL), ketonemia, ketonuria, low bicarbonate levels (<18 mEq/L), and an elevated anion gap metabolic acidosis.

Treatment:
Immediate fluid resuscitation (IV fluids), insulin therapy, electrolyte replacement (especially potassium), and addressing precipitating factors (e.g., infections).

Medications:
Regular insulin (short-acting insulin for IV infusion to lower blood glucose and suppress ketone production), potassium supplements (for electrolyte correction), bicarbonate (in severe acidosis cases, though used cautiously).

Prevalence: How common the health condition is within a specific population.
Common in individuals with type 1 diabetes and occasionally in type 2 diabetes under stress or illness.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Poor diabetes management, infections, physical or emotional stress, skipping insulin doses, undiagnosed diabetes.

Prognosis: The expected outcome or course of the condition over time.
Favorable if treated promptly; mortality is low with appropriate intervention but rises if untreated.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Cerebral edema (especially in children), hypokalemia, cardiac arrhythmias, hypoglycemia, and multi-organ failure in severe cases.

Thyroid Storm

Specialty: Emergency and Urgent Care

Category: Endocrine and Metabolic Emergencies

Sub-category: Thyroid Conditions

Symptoms:
high fever; rapid heart rate (tachycardia); extreme irritability or agitation; confusion or delirium; profuse sweating; nausea; vomiting; diarrhea; heart failure symptoms (chest pain, shortness of breath); goiter

Root Cause:
Excessive release of thyroid hormones (T3 and T4) leading to a hypermetabolic state, often triggered by infection, trauma, surgery, or discontinuation of antithyroid medications in patients with hyperthyroidism.

How it's Diagnosed: videos
Clinical presentation supported by laboratory findings of extremely elevated free T3 and T4 levels, suppressed TSH levels, and systemic organ dysfunction. Other tests may include CBC, liver enzymes, and imaging (to rule out precipitating factors).

Treatment:
Aggressive supportive care, cooling measures for hyperthermia, hydration, electrolyte correction, beta-blockers to control heart rate, antithyroid drugs, iodine to block thyroid hormone release, and corticosteroids to reduce peripheral conversion of T4 to T3.

Medications:
Antithyroid drugs

Prevalence: How common the health condition is within a specific population.
Rare but life-threatening; typically occurs in patients with untreated or poorly managed hyperthyroidism.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Graves’ disease, toxic multinodular goiter, thyroid surgery, infection, trauma, pregnancy, discontinuation of antithyroid drugs, or iodine contrast administration.

Prognosis: The expected outcome or course of the condition over time.
High mortality rate (up to 20-30%) if untreated; early and aggressive treatment significantly improves outcomes.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Heart failure, arrhythmias (e.g., atrial fibrillation), shock, multi-organ failure, and death.

Hyponatremia

Specialty: Nephrology

Category: Electrolyte and Acid-Base Disorders

Symptoms:
nausea; vomiting; confusion; headache; seizures; fatigue; restlessness; muscle weakness or spasms; coma in severe cases

Root Cause:
Low sodium concentration in the blood, often caused by excessive water retention, sodium loss, or a combination of both.

How it's Diagnosed: videos
Blood tests measuring serum sodium levels (<135 mEq/L), urine sodium and osmolality, and clinical evaluation of symptoms.

Treatment:
Treatment focuses on addressing the underlying cause, restricting fluid intake, or administering sodium supplementation. Severe cases may require hypertonic saline.

Medications:
Tolvaptan or conivaptan (vasopressin receptor antagonists), diuretics like loop diuretics (e.g., furosemide ) for certain cases, and sodium chloride for supplementation.

Prevalence: How common the health condition is within a specific population.
Common, particularly in hospitalized patients; estimated at 15–30% in such settings.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Heart failure, liver cirrhosis, kidney disease, SIADH, use of diuretics, excessive water intake, and advanced age.

Prognosis: The expected outcome or course of the condition over time.
Generally good if treated promptly, but severe hyponatremia can lead to permanent neurological damage or death if untreated.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Cerebral edema, seizures, coma, central pontine myelinolysis (from overly rapid correction).

Hypercalcemia

Specialty: Nephrology

Category: Electrolyte and Acid-Base Disorders

Symptoms:
nausea; vomiting; constipation; polyuria; kidney stones; confusion; lethargy; arrhythmias

Root Cause:
Elevated calcium levels in the blood due to increased bone resorption, excessive intake, or abnormal regulation by parathyroid hormone.

How it's Diagnosed: videos
Blood tests showing serum calcium >10.5 mg/dL, PTH levels, and clinical evaluation of symptoms.

Treatment:
IV fluids, bisphosphonates, calcitonin, and addressing the underlying cause (e.g., surgery for hyperparathyroidism).

Medications:
Bisphosphonates (e.g., pamidronate , zoledronic acid), calcitonin (reduces calcium levels), and corticosteroids for specific conditions.

Prevalence: How common the health condition is within a specific population.
Common, particularly in patients with malignancy or hyperparathyroidism.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Hyperparathyroidism, malignancy, excessive calcium/vitamin D intake, and prolonged immobility.

Prognosis: The expected outcome or course of the condition over time.
Good with proper treatment; severe hypercalcemia can lead to renal failure or cardiac arrest.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Kidney stones, nephrocalcinosis, arrhythmias, and neuropsychiatric disturbances.

Acute Kidney Injury (AKI)

Specialty: Nephrology

Category: Chronic and Acute Kidney Diseases

Symptoms:
decreased urine output; swelling in legs, ankles, or feet; nausea; confusion; fatigue; chest pain or pressure; shortness of breath

Root Cause:
Sudden loss of kidney function due to reduced blood flow, damage to kidney tissue, or blockage of urinary outflow.

How it's Diagnosed: videos
Blood tests (e.g., elevated creatinine), decreased urine output, and imaging studies to identify potential obstructions.

Treatment:
Addressing the underlying cause, restoring fluid balance, removing toxins, and temporary dialysis if needed.

Medications:
Medications may include diuretics (e.g., furosemide ), electrolyte binders (e.g., sodium polystyrene sulfonate ), and vasopressors in cases of low blood pressure.

Prevalence: How common the health condition is within a specific population.
Occurs in approximately 20% of hospitalized patients; higher risk in critical care settings.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Advanced age, pre-existing kidney disease, diabetes, sepsis, major surgery, or exposure to nephrotoxic drugs.

Prognosis: The expected outcome or course of the condition over time.
Variable; reversible in many cases, but severe or prolonged AKI can lead to chronic kidney damage or failure.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Electrolyte imbalances, fluid overload, chronic kidney disease, and increased risk of mortality.

Uremia

Specialty: Emergency and Urgent Care

Category: Renal and Urologic Emergencies

Sub-category: Renal Failure Complications

Symptoms:
nausea; vomiting; loss of appetite; fatigue; confusion; seizures; muscle cramps; itching; fluid retention; shortness of breath; high blood pressure; altered mental status

Root Cause:
Accumulation of urea and other nitrogenous waste products in the blood due to impaired kidney function. This condition arises from chronic or acute renal failure, leading to toxic effects on multiple organ systems.

How it's Diagnosed: videos
Blood tests showing elevated blood urea nitrogen (BUN) and creatinine levels, electrolyte imbalances, and metabolic acidosis; urinalysis may indicate proteinuria or hematuria; imaging (ultrasound or CT) may show kidney abnormalities. Clinical symptoms and history are also critical.

Treatment:
Emergency treatment includes dialysis (hemodialysis or peritoneal dialysis) to remove waste products and restore electrolyte balance. Supportive care includes addressing fluid overload and managing complications such as hypertension and metabolic acidosis.

Medications:
Diuretics (e.g., furosemide )

Prevalence: How common the health condition is within a specific population.
Common among individuals with advanced chronic kidney disease (CKD) or acute kidney injury (AKI); incidence rises in end-stage renal disease (ESRD) patients.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Chronic kidney disease, acute kidney injury, diabetes mellitus, hypertension, advanced age, polycystic kidney disease, and autoimmune disorders affecting the kidneys (e.g., lupus nephritis).

Prognosis: The expected outcome or course of the condition over time.
With timely dialysis and treatment, symptoms can be managed effectively; however, the underlying renal disease usually remains progressive without a transplant. Untreated uremia is life-threatening.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Cardiac arrhythmias, pericarditis, seizures, encephalopathy, fluid overload, and death if untreated.

Severe Electrolyte Imbalances

Specialty: Emergency and Urgent Care

Category: Renal and Urologic Emergencies

Sub-category: Electrolyte Disorders

Symptoms:
muscle weakness; cramps; nausea; confusion; seizures; cardiac arrhythmias; paralysis; fatigue; tetany; altered mental status

Root Cause:
Abnormal levels of critical electrolytes such as potassium, sodium, calcium, magnesium, and phosphate in the blood, resulting from renal dysfunction, medications, endocrine disorders, or fluid imbalance.

How it's Diagnosed: videos
Blood tests for electrolyte levels, arterial blood gas analysis for acid-base status, and ECG to detect arrhythmias. History and clinical examination are also key.

Treatment:
Depends on the specific electrolyte imbalance

Medications:
Calcium supplements (e.g., calcium gluconate)

Prevalence: How common the health condition is within a specific population.
Common in hospitalized patients, particularly those with kidney disease, heart failure, or endocrine disorders.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Chronic kidney disease, diuretics, excessive fluid loss, endocrine disorders (e.g., diabetes insipidus, SIADH), and critical illnesses.

Prognosis: The expected outcome or course of the condition over time.
With prompt recognition and treatment, outcomes are typically favorable; however, severe imbalances can cause life-threatening complications if untreated.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Cardiac arrest, respiratory failure, seizures, neuromuscular dysfunction, and multi-organ failure.

Tumor Lysis Syndrome

Specialty: Oncology

Category: Sarcomas

Sub-category: Treatment-Related Complications

Symptoms:
hyperkalemia; hyperphosphatemia; hypocalcemia; elevated creatinine; nausea; vomiting; fatigue; muscle cramps; seizures

Root Cause:
The rapid release of intracellular contents from dying tumor cells, often after chemotherapy or other treatments, leading to metabolic disturbances.

How it's Diagnosed: videos
Blood tests to measure levels of potassium, phosphate, calcium, creatinine, and uric acid. Clinical presentation and history of recent cancer treatment.

Treatment:
Hydration, medications to control electrolyte imbalances (e.g., sodium bicarbonate, allopurinol), dialysis if necessary, and monitoring in a hospital setting.

Medications:
Allopurinol (a xanthine oxidase inhibitor that reduces uric acid production), Rasburicase (an enzyme that breaks down uric acid), Sodium bicarbonate (to alkalinize urine and prevent uric acid crystallization), Calcium gluconate (to treat hypocalcemia), Potassium binders (to reduce hyperkalemia). These medications are considered urate-lowering agents, electrolyte modifiers, and anti-hyperkalemic agents.

Prevalence: How common the health condition is within a specific population.
This is a relatively rare condition, occurring in approximately 5-10% of patients receiving chemotherapy for high-grade hematologic cancers like leukemia and lymphoma.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
High tumor burden, especially in hematologic malignancies, rapid tumor cell turnover, and treatments like chemotherapy or radiation therapy.

Prognosis: The expected outcome or course of the condition over time.
With early detection and treatment, prognosis can be good. However, untreated tumor lysis syndrome can lead to organ failure and death.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Renal failure, cardiac arrhythmias, seizures, and death if not managed promptly.

Acetaminophen overdose

Specialty: Emergency and Urgent Care

Category: Toxicology and Overdose

Sub-category: Drug Overdoses

Symptoms:
nausea; vomiting; abdominal pain; confusion; jaundice (late stage); elevated liver enzymes

Root Cause:
Excessive acetaminophen overwhelms the liver's ability to conjugate and detoxify NAPQI (toxic metabolite), causing hepatocellular damage.

How it's Diagnosed: videos
History of overdose, serum acetaminophen levels, and liver function tests (LFTs); use of the Rumack-Matthew nomogram for risk assessment.

Treatment:
N-acetylcysteine (NAC) administration (oral or IV) to replenish glutathione, activated charcoal if within 1-2 hours of ingestion, and supportive care.

Medications:
N-acetylcysteine (antidote for acetaminophen toxicity) and activated charcoal (gastric decontaminant).

Prevalence: How common the health condition is within a specific population.
Acetaminophen toxicity is one of the most common causes of drug overdoses globally and a leading cause of acute liver failure in the U.S.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Chronic acetaminophen use, concurrent alcohol consumption, pre-existing liver disease, and taking higher-than-recommended doses.

Prognosis: The expected outcome or course of the condition over time.
Good with early treatment; delayed treatment increases the risk of liver failure, necessitating a liver transplant.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Acute liver failure, metabolic acidosis, encephalopathy, and death.

Carbon Monoxide Poisoning

Specialty: Emergency and Urgent Care

Category: Toxicology and Overdose

Sub-category: Chemical Exposures

Symptoms:
headache; dizziness; nausea; shortness of breath; confusion; loss of consciousness; chest pain; seizures

Root Cause:
Carbon monoxide binds to hemoglobin with a higher affinity than oxygen, reducing oxygen delivery to tissues and causing hypoxia.

How it's Diagnosed: videos
Measurement of carboxyhemoglobin levels in blood using co-oximetry, pulse CO-oximeter, or arterial blood gas analysis. Symptoms and exposure history also aid diagnosis.

Treatment:
Immediate removal from the CO exposure source, 100% oxygen therapy through a non-rebreather mask, or hyperbaric oxygen therapy in severe cases.

Medications:
No direct medications, but 100% oxygen therapy and hyperbaric oxygen are the main treatments. Hyperbaric oxygen is classified as a high-pressure oxygen delivery treatment.

Prevalence: How common the health condition is within a specific population.
A leading cause of poisoning-related deaths worldwide, with an estimated 50,000 emergency department visits annually in the U.S.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Poorly ventilated spaces, faulty heating systems, exposure to fires, and use of charcoal or gas grills indoors.

Prognosis: The expected outcome or course of the condition over time.
Good with timely treatment; delayed or severe exposure may lead to long-term neurological complications.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Neurological sequelae (e.g., memory loss, difficulty concentrating), myocardial ischemia, arrhythmias, and death.

Cyanide Poisoning

Specialty: Emergency and Urgent Care

Category: Toxicology and Overdose

Sub-category: Chemical Exposures

Symptoms:
shortness of breath; confusion; headache; nausea; seizures; loss of consciousness; cardiac arrest

Root Cause:
Cyanide inhibits cytochrome oxidase in mitochondria, blocking cellular respiration and leading to rapid tissue hypoxia.

How it's Diagnosed: videos
Clinical suspicion based on exposure history, measurement of cyanide levels in blood, arterial blood gas showing metabolic acidosis with high lactate.

Treatment:
Administration of specific antidotes (e.g., hydroxocobalamin, sodium thiosulfate) and supportive care, including oxygen therapy and mechanical ventilation if needed.

Medications:
Hydroxocobalamin (binds cyanide to form cyanocobalamin , excreted in urine), Sodium thiosulfate (enhances cyanide metabolism to thiocyanate), and Nitrites (to induce methemoglobin formation, binding cyanide). These are classified as antidotes.

Prevalence: How common the health condition is within a specific population.
Rare in the general population but associated with industrial exposures, smoke inhalation from fires, and deliberate ingestion.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Exposure to industrial chemicals, smoke inhalation from fires, ingestion of cyanogenic compounds (e.g., amygdalin in apricot seeds).

Prognosis: The expected outcome or course of the condition over time.
Excellent with early and appropriate treatment; poor prognosis in delayed or severe cases without intervention.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Hypoxic brain injury, multi-organ failure, and death.

Snake Bites

Specialty: Emergency and Urgent Care

Category: Toxicology and Overdose

Sub-category: Envenomations

Symptoms:
localized pain and swelling; redness; bruising; nausea; vomiting; difficulty breathing; altered mental status; bleeding disorders; paralysis

Root Cause:
Snake venom contains a mixture of proteins, enzymes, and toxins that disrupt blood coagulation, damage tissues, and interfere with the nervous system or cardiovascular function.

How it's Diagnosed: videos
Clinical history, observation of bite marks, identification of the snake (if possible), blood tests for coagulation disorders, and monitoring for systemic effects.

Treatment:
Antivenom administration specific to the snake species, wound care, supportive care (e.g., IV fluids, oxygen), and monitoring for complications.

Medications:
Antivenom

Prevalence: How common the health condition is within a specific population.
Estimated 5.4 million bites occur worldwide annually, with approximately 2.7 million envenomations and 81,000–138,000 deaths.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Outdoor activities in snake habitats, lack of protective footwear, delayed medical care, and inadequate access to antivenom.

Prognosis: The expected outcome or course of the condition over time.
Good if treated promptly with appropriate antivenom; delayed treatment increases the risk of permanent damage or death.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Tissue necrosis, compartment syndrome, coagulopathy, renal failure, and systemic shock.

Marine Envenomations (e.g., Jellyfish, Stingrays)

Specialty: Emergency and Urgent Care

Category: Toxicology and Overdose

Sub-category: Envenomations

Symptoms:
localized pain; burning or stinging sensation; redness and swelling; nausea; vomiting; difficulty breathing; muscle cramps; cardiac symptoms in severe cases

Root Cause:
Toxins from marine animals cause local or systemic effects, including tissue damage, allergic reactions, and cardiovascular disturbances.

How it's Diagnosed: videos
Clinical history, observation of sting site, identification of the marine animal, and symptom assessment.

Treatment:
Removal of stingers or spines, rinsing with vinegar or hot water, pain management, and supportive care. Antivenom may be used for specific stings (e.g., box jellyfish).

Medications:
Pain Relievers

Prevalence: How common the health condition is within a specific population.
Common in coastal regions; thousands of cases occur annually worldwide.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Swimming or diving in marine environments, inadequate protective measures (e.g., wetsuits).

Prognosis: The expected outcome or course of the condition over time.
Excellent with appropriate treatment; severe cases (e.g., box jellyfish stings) require prompt intervention.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Severe allergic reactions, tissue necrosis, infection, and cardiac arrest in rare cases.

Alcohol Withdrawal Syndrome

Specialty: Toxicology

Category: Acute Poisoning

Sub-category: Alcohol-Related Toxicity

Symptoms:
tremors; sweating; anxiety; nausea; vomiting; seizures; hallucinations; delirium tremens

Root Cause:
Sudden cessation or reduction of chronic alcohol consumption leading to central nervous system hyperactivity due to downregulated GABA and upregulated glutamate pathways.

How it's Diagnosed: videos
Clinical history, assessment using tools like the Clinical Institute Withdrawal Assessment for Alcohol (CIWA-Ar) scale, and ruling out other causes of symptoms.

Treatment:
Benzodiazepines (e.g., diazepam, lorazepam), thiamine to prevent Wernicke’s encephalopathy, and supportive care.

Medications:
Diazepam or lorazepam (benzodiazepines) are first-line treatments to control withdrawal symptoms and prevent seizures. Thiamine (vitamin B1) is used to prevent neurological complications.

Prevalence: How common the health condition is within a specific population.
Occurs in approximately 50% of individuals with chronic alcohol use disorder who suddenly stop drinking. Severe forms (delirium tremens) occur in about 5%.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Chronic alcohol use, history of withdrawal seizures, concurrent illness, electrolyte imbalances, malnutrition.

Prognosis: The expected outcome or course of the condition over time.
With treatment, symptoms resolve within a few days; untreated severe withdrawal can be life-threatening.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Seizures, delirium tremens, Wernicke-Korsakoff syndrome, arrhythmias, death.

Ovarian Torsion

Specialty: Emergency and Urgent Care

Category: Obstetric and Gynecologic Emergencies

Sub-category: Gynecologic Conditions

Symptoms:
sudden severe pelvic or abdominal pain; nausea; vomiting; abdominal tenderness; fever (occasionally)

Root Cause:
Twisting of the ovary and sometimes the fallopian tube, which compromises blood flow to the ovary. Often associated with ovarian cysts or masses.

How it's Diagnosed: videos
Clinical history, physical exam, transvaginal or pelvic ultrasound with Doppler to assess blood flow to the ovary, and occasionally diagnostic laparoscopy.

Treatment:
Emergency surgical intervention (laparoscopy or laparotomy) to untwist the ovary and preserve ovarian function. In some cases, oophorectomy (removal of the ovary) may be necessary.

Medications:
Pain relief is often managed with analgesics such as NSAIDs or opioids. Post-surgery antibiotics may be used to prevent infection. Examples - Ibuprofen (NSAID), Morphine (opioid), and Ceftriaxone (antibiotic).

Prevalence: How common the health condition is within a specific population.
Relatively rare; accounts for about 3% of gynecologic emergencies.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Ovarian cysts or tumors, pregnancy, hormonal treatments for ovulation induction, previous ovarian torsion, long ovarian ligaments.

Prognosis: The expected outcome or course of the condition over time.
Good if treated promptly. Delay in treatment can lead to ovarian necrosis and loss of ovarian function.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Infertility, ovarian necrosis, peritonitis, sepsis, and in severe cases, death.

Benign Paroxysmal Positional Vertigo (BPPV)

Specialty: Ear

Category: Balance and Vestibular Disorders

Sub-category: Peripheral Vestibular Disorders

Symptoms:
brief episodes of dizziness; spinning sensation (vertigo); nausea; loss of balance; lightheadedness; symptoms triggered by head movements

Root Cause:
Displacement of calcium carbonate crystals (otoconia) from the utricle into the semicircular canals, causing abnormal signaling to the brain during head movements.

How it's Diagnosed: videos
Dix-Hallpike maneuver or supine roll test; observation of nystagmus during diagnostic maneuvers.

Treatment:
Canalith repositioning maneuvers (e.g., Epley or Semont maneuver), vestibular rehabilitation therapy.

Medications:
Medications are rarely used but may include vestibular suppressants like meclizine (an antihistamine) or diazepam (a benzodiazepine) to alleviate acute vertigo symptoms temporarily.

Prevalence: How common the health condition is within a specific population.
Approximately 0.5-2% of the population, more common in older adults.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Advanced age, head trauma, prolonged bed rest, inner ear disorders, osteoporosis.

Prognosis: The expected outcome or course of the condition over time.
Generally excellent; symptoms often resolve with repositioning maneuvers, though recurrence is common.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Increased risk of falls, anxiety related to vertigo episodes, potential for chronic dizziness in rare cases.

Labyrinthitis

Specialty: Ear

Category: Balance and Vestibular Disorders

Sub-category: Peripheral Vestibular Disorders

Symptoms:
vertigo; hearing loss; tinnitus; nausea; imbalance; difficulty focusing visually

Root Cause:
Inflammation of both the vestibular and cochlear components of the inner ear, often from viral or bacterial infections.

How it's Diagnosed: videos
Audiometry, vestibular tests, clinical evaluation to rule out central causes like stroke.

Treatment:
Rest, vestibular rehabilitation, corticosteroids, antibiotics if bacterial infection is suspected.

Medications:
Prednisone for inflammation; amoxicillin or ceftriaxone for bacterial infections; meclizine or diazepam for acute symptoms.

Prevalence: How common the health condition is within a specific population.
Incidence is unclear; commonly occurs after viral infections.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Upper respiratory infections, middle ear infections, weakened immune system.

Prognosis: The expected outcome or course of the condition over time.
Often resolves completely, though hearing loss may be permanent in some cases.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Chronic dizziness, permanent hearing loss, anxiety.

Perilymph Fistula

Specialty: Ear

Category: Balance and Vestibular Disorders

Sub-category: Peripheral Vestibular Disorders

Symptoms:
vertigo; imbalance; hearing loss; tinnitus; pressure changes exacerbating symptoms; nausea

Root Cause:
Abnormal communication between the middle ear and inner ear, causing leakage of perilymph fluid.

How it's Diagnosed: videos
Clinical history, vestibular testing, confirmation via exploratory surgery.

Treatment:
Rest, avoiding activities that increase intracranial pressure, surgical repair if conservative measures fail.

Medications:
None specific; symptomatic relief with meclizine or ondansetron for nausea.

Prevalence: How common the health condition is within a specific population.
Rare; associated with head trauma or barotrauma.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Head injury, barotrauma, vigorous straining or heavy lifting.

Prognosis: The expected outcome or course of the condition over time.
Good with surgical intervention; untreated cases may lead to persistent symptoms.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Progressive hearing loss, chronic dizziness.

Vestibular Migraine

Specialty: Ear

Category: Balance and Vestibular Disorders

Sub-category: Central Vestibular Disorders

Symptoms:
dizziness; vertigo; imbalance; motion sensitivity; nausea; light/sound sensitivity; headaches associated with episodes

Root Cause:
A neurological condition involving abnormal sensory signal processing in the brain, potentially linked to migraine pathophysiology.

How it's Diagnosed: videos
Based on clinical criteria, patient history, and exclusion of other conditions; imaging (e.g., MRI) may be used to rule out structural causes.

Treatment:
Lifestyle changes, avoidance of triggers, vestibular rehabilitation therapy, and pharmacological management of migraine.

Medications:
Beta-blockers (e.g., propranolol ), calcium channel blockers (e.g., verapamil ), anticonvulsants (e.g., topiramate ), or triptans for acute attacks. Medications belong to prophylactic migraine treatments, acute migraine treatments, and vestibular suppressants.

Prevalence: How common the health condition is within a specific population.
Estimated to affect approximately 1% of the population; more common in women.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Personal or family history of migraines, stress, hormonal changes, and certain foods or sensory triggers.

Prognosis: The expected outcome or course of the condition over time.
Generally manageable with treatment, though some individuals may experience recurrent or chronic symptoms.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Impaired quality of life, risk of falls due to imbalance, anxiety, and depression.

Brainstem or Cerebellar Lesions (e.g., Stroke, Multiple Sclerosis)

Specialty: Ear

Category: Balance and Vestibular Disorders

Sub-category: Central Vestibular Disorders

Symptoms:
dizziness; vertigo; ataxia (lack of coordination); imbalance; visual disturbances; nausea; difficulty speaking; facial numbness or weakness

Root Cause:
Damage to the brainstem or cerebellum due to ischemia (stroke), demyelination (multiple sclerosis), or other neurological conditions.

How it's Diagnosed: videos
Clinical evaluation, imaging studies (MRI/CT scans), and neurological exams; additional tests like lumbar puncture for MS.

Treatment:
Depends on the cause

Medications:
For strokes

Prevalence: How common the health condition is within a specific population.
Stroke prevalence varies widely, with millions affected annually worldwide; MS affects approximately 2.8 million globally.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
For strokes

Prognosis: The expected outcome or course of the condition over time.
Stroke prognosis varies based on severity and timing of intervention; MS is chronic and progressive but can be managed with treatment.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Long-term disability, chronic dizziness, visual disturbances, cognitive deficits, and emotional challenges like depression.

Labyrinthitis (Inner Ear Infection Affecting Hearing and Balance)

Specialty: Ear

Category: Infectious and Inflammatory Ear Conditions

Sub-category: Inner Ear Infections

Symptoms:
vertigo; dizziness; nausea; vomiting; loss of balance; hearing loss; tinnitus (ringing in the ears); difficulty focusing the eyes

Root Cause:
Inflammation or infection of the labyrinth (inner ear), typically due to a viral or bacterial cause, affecting both the vestibular and auditory systems.

How it's Diagnosed: videos
Clinical evaluation based on symptoms and history, physical examination, hearing tests (audiometry), and sometimes imaging studies (MRI or CT) to rule out other causes like stroke.

Treatment:
Rest, hydration, physical therapy for balance (vestibular rehabilitation therapy), and medications to alleviate symptoms. If bacterial, antibiotics may be prescribed.

Medications:
Antihistamines (e.g., meclizine ) for vertigo. Benzodiazepines (e.g., diazepam ) to suppress vestibular symptoms. Antiemetics (e.g., prochlorperazine ) for nausea and vomiting. Corticosteroids (e.g., prednisone ) to reduce inflammation in severe cases. Antibiotics (e.g., amoxicillin ) if a bacterial infection is confirmed.

Prevalence: How common the health condition is within a specific population.
Common, especially in adults aged 30–60; exact prevalence varies but is more frequent during viral outbreaks (e.g., flu season).

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Recent viral or bacterial infections, respiratory illnesses, weakened immune system, history of ear infections, and smoking.

Prognosis: The expected outcome or course of the condition over time.
Good for most cases; symptoms usually improve within a few weeks to months. Persistent balance issues or hearing loss can occur in severe cases.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Chronic dizziness, permanent hearing loss, and secondary conditions like anxiety due to prolonged vertigo episodes.

Stable Angina

Specialty: Cardiovascular

Category: Heart Diseases

Sub-category: Coronary Artery Disease (CAD)

Symptoms:
chest pain or discomfort triggered by physical activity or stress; pain usually subsides with rest; shortness of breath; nausea

Root Cause:
Reduced blood flow to the heart due to atherosclerosis in the coronary arteries.

How it's Diagnosed: videos
Electrocardiogram (ECG); exercise stress test; coronary angiography; blood tests for cardiac enzymes

Treatment:
Lifestyle modifications, medications to improve blood flow and reduce heart workload, and coronary interventions if needed.

Medications:
Medications include nitrates (e.g., nitroglycerin ) to relieve chest pain, beta-blockers (e.g., atenolol ) to reduce heart workload, calcium channel blockers (e.g., amlodipine ), and antiplatelet agents (e.g., aspirin ) to prevent clot formation.

Prevalence: How common the health condition is within a specific population.
Common in individuals with coronary artery disease, especially those aged 50+.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Smoking; high cholesterol; high blood pressure; obesity; sedentary lifestyle; family history of heart disease

Prognosis: The expected outcome or course of the condition over time.
Symptoms are controllable with medications and lifestyle changes, but it may progress to more severe forms of coronary artery disease.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Progression to unstable angina; myocardial infarction; heart failure

Diabetes during pregnancy

Specialty: Diabetes and Endocrinology

Category: Diabetes Mellitus and Related Disorders

Sub-category: Gestational Diabetes Mellitus (GDM)

Symptoms:
increased thirst; frequent urination; fatigue; blurred vision; unexplained weight changes; nausea; slow-healing infections

Root Cause:
Insulin resistance due to hormonal changes during pregnancy, combined with an inability of the pancreas to produce sufficient insulin to maintain normal glucose levels.

How it's Diagnosed: videos
Diagnosis is through glucose screening tests such as the oral glucose tolerance test (OGTT) conducted during the second trimester (usually between 24 and 28 weeks of pregnancy).

Treatment:
Management involves dietary modifications, regular physical activity, blood glucose monitoring, and, if needed, medications to regulate blood sugar levels.

Medications:
Insulin therapy is the primary treatment if blood sugar cannot be controlled through lifestyle changes. Additionally, oral medications such as metformin (a biguanide that improves insulin sensitivity) or glyburide (a sulfonylurea that increases insulin secretion) may be prescribed in some cases.

Prevalence: How common the health condition is within a specific population.
Gestational diabetes affects approximately 6-9% of pregnancies globally, with higher rates in certain populations.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Family history of diabetes; overweight or obesity; advanced maternal age; previous history of gestational diabetes; ethnic predisposition (e.g., South Asian, African-American, Hispanic); polycystic ovary syndrome (PCOS)

Prognosis: The expected outcome or course of the condition over time.
Most women with gestational diabetes return to normal glucose levels after delivery. However, they remain at higher risk of developing type 2 diabetes in the future.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Macrosomia (large baby size); increased risk of cesarean delivery; neonatal hypoglycemia; respiratory distress syndrome in newborn; increased risk of preeclampsia for the mother; future metabolic disorders in both mother and child

Primary (Addison’s Disease)

Specialty: Diabetes and Endocrinology

Category: Adrenal Disorders

Sub-category: Adrenal Insufficiency

Symptoms:
fatigue; weight loss; muscle weakness; low blood pressure; salt cravings; hyperpigmentation of the skin; nausea; vomiting; abdominal pain; hypoglycemia

Root Cause:
Destruction or dysfunction of the adrenal cortex leads to insufficient production of cortisol and, often, aldosterone.

How it's Diagnosed: videos
Diagnosis involves clinical evaluation, blood tests showing low cortisol and high ACTH levels, and confirmation with an ACTH stimulation test. Electrolyte imbalances (e.g., hyponatremia, hyperkalemia) and low aldosterone may also be observed.

Treatment:
Lifelong hormone replacement therapy with glucocorticoids and mineralocorticoids, stress management, and patient education on managing adrenal crises.

Medications:
Medications include hydrocortisone or prednisone (glucocorticoids) to replace cortisol and fludrocortisone (a mineralocorticoid) to replace aldosterone. These are classified as corticosteroid replacement therapies.

Prevalence: How common the health condition is within a specific population.
Rare; approximately 1 in 100,000 people are affected, with equal distribution across genders.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Autoimmune diseases (e.g., autoimmune polyendocrine syndrome), infections (e.g., tuberculosis), adrenal hemorrhage, or genetic predisposition.

Prognosis: The expected outcome or course of the condition over time.
With proper treatment, individuals can live normal lives, but they must manage the risk of adrenal crises, especially during stress or illness.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Adrenal crisis (life-threatening), severe hypotension, electrolyte imbalances, and hypoglycemia.

Secondary Adrenal Insufficiency (e.g., Pituitary Dysfunction)

Specialty: Diabetes and Endocrinology

Category: Adrenal Disorders

Sub-category: Adrenal Insufficiency

Symptoms:
fatigue; muscle weakness; low blood pressure; nausea; vomiting; dizziness; hypoglycemia

Root Cause:
Inadequate production of ACTH by the pituitary gland leads to insufficient stimulation of the adrenal glands, resulting in low cortisol levels.

How it's Diagnosed: videos
Diagnosis involves measuring cortisol and ACTH levels, as well as dynamic testing (e.g., ACTH stimulation test, insulin tolerance test). Brain imaging (MRI) may be used to identify pituitary abnormalities.

Treatment:
Glucocorticoid replacement therapy and, if applicable, addressing the underlying cause (e.g., pituitary tumor or discontinuation of long-term corticosteroid use).

Medications:
Medications include hydrocortisone or prednisone to replace cortisol. These are classified as glucocorticoid replacement therapies.

Prevalence: How common the health condition is within a specific population.
More common than primary adrenal insufficiency; often associated with prolonged corticosteroid use or pituitary dysfunction. Exact prevalence is unclear but estimated to be higher than Addison's disease.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Long-term corticosteroid use, pituitary tumors, traumatic brain injury, or radiation therapy to the brain.

Prognosis: The expected outcome or course of the condition over time.
Generally favorable with treatment, but adrenal crises may occur during stress or illness if glucocorticoid dosing is not increased.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Adrenal crisis, persistent fatigue, hypoglycemia, and dependence on hormone replacement therapy.

Hypopituitarism (Deficiency of Pituitary Hormones)

Specialty: Diabetes and Endocrinology

Category: Pituitary Disorders

Sub-category: Pituitary Insufficiency

Symptoms:
fatigue; weakness; weight changes; cold intolerance; low libido; decreased appetite; nausea; dizziness; infertility; growth delays in children

Root Cause:
Reduced or absent production of one or more pituitary hormones due to damage or dysfunction of the pituitary gland or hypothalamus.

How it's Diagnosed: videos
Blood tests to measure hormone levels (e.g., ACTH, TSH, GH, LH, FSH), MRI of the pituitary gland, stimulation tests for specific hormones.

Treatment:
Hormone replacement therapy tailored to the deficient hormones (e.g., cortisol, thyroid hormone, sex hormones, growth hormone).

Medications:
Hormone replacement medications include hydrocortisone or prednisone for adrenal insufficiency (glucocorticoids), levothyroxine for hypothyroidism (thyroid hormone replacement), and testosterone or estrogen/progesterone for hypogonadism (sex hormone therapy). Recombinant human growth hormone (GH) may be prescribed for growth hormone deficiency.

Prevalence: How common the health condition is within a specific population.
Estimated to affect approximately 45 per 100,000 people.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Pituitary tumors, traumatic brain injury, radiation therapy to the head, autoimmune conditions, infections, genetic mutations.

Prognosis: The expected outcome or course of the condition over time.
Lifelong management is required with good outcomes if hormone replacement is adequate.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Adrenal crisis, osteoporosis, cardiovascular disease, infertility, psychological effects such as depression or anxiety.

Sheehan’s Syndrome (Postpartum Hypopituitarism)

Specialty: Diabetes and Endocrinology

Category: Pituitary Disorders

Sub-category: Postpartum Endocrine Disorders

Symptoms:
fatigue; inability to lactate; loss of pubic and axillary hair; low blood pressure; cold intolerance; weight loss; amenorrhea; nausea

Root Cause:
Pituitary gland necrosis caused by severe blood loss or hypovolemic shock during or after childbirth.

How it's Diagnosed: videos
Clinical history of postpartum hemorrhage, blood tests for hormone levels, MRI of the pituitary gland.

Treatment:
Lifelong hormone replacement therapy, including cortisol (hydrocortisone or prednisone), levothyroxine, and sex hormones as needed.

Medications:
Hydrocortisone or prednisone for adrenal insufficiency, levothyroxine for thyroid hormone replacement, and estrogen/progesterone or testosterone for sex hormone deficiency.

Prevalence: How common the health condition is within a specific population.
Occurs in about 1 in 10,000 deliveries, more common in low-resource settings with inadequate obstetric care.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Severe postpartum hemorrhage, prolonged labor, multiple pregnancies, anemia, low-resource settings.

Prognosis: The expected outcome or course of the condition over time.
Manageable with appropriate hormone replacement therapy, but quality of life depends on timely diagnosis and treatment.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Adrenal crisis, infertility, osteoporosis, psychological effects such as depression or anxiety.

Primary Hyperparathyroidism (e.g., Parathyroid Adenoma)

Specialty: Diabetes and Endocrinology

Category: Parathyroid Disorders

Sub-category: Hyperparathyroidism

Symptoms:
fatigue; muscle weakness; bone pain; nausea; kidney stones; constipation; polyuria; depression; confusion

Root Cause:
Overproduction of parathyroid hormone (PTH) caused by a benign tumor (adenoma) in one or more parathyroid glands, leading to elevated calcium levels.

How it's Diagnosed: videos
Blood tests (elevated calcium and PTH levels), 24-hour urine calcium test, imaging studies like ultrasound or Sestamibi scan for adenoma localization.

Treatment:
Surgical removal of the adenoma (parathyroidectomy); non-surgical management includes hydration and medications to control calcium levels.

Medications:
Calcimimetics (e.g., cinacalcet , which decreases PTH secretion), bisphosphonates (e.g., alendronate , to reduce bone resorption), and vitamin D supplements if indicated.

Prevalence: How common the health condition is within a specific population.
Affects approximately 1–3 per 1,000 individuals, with a higher prevalence in postmenopausal women.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Female sex, age over 50, genetic predisposition, prolonged lithium or radiation exposure.

Prognosis: The expected outcome or course of the condition over time.
Excellent prognosis with surgery; most symptoms resolve after treatment, though bone density recovery may take time.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Osteoporosis, kidney stones, chronic kidney disease, cardiovascular issues due to hypercalcemia.

Hypermagnesemia

Specialty: Nephrology

Category: Electrolyte and Acid-Base Disorders

Symptoms:
nausea; vomiting; weakness; hypotension; respiratory depression; bradycardia; lethargy; decreased deep tendon reflexes; cardiac arrest in severe cases

Root Cause:
Excess magnesium in the blood, often due to impaired kidney function, excessive magnesium intake, or use of magnesium-containing medications.

How it's Diagnosed: videos
Blood tests to measure serum magnesium levels, alongside kidney function tests and electrolyte panels.

Treatment:
Discontinuation of magnesium-containing products, intravenous calcium gluconate (to stabilize cardiac membranes), diuretics to promote magnesium excretion, and dialysis in severe cases.

Medications:
Calcium gluconate (calcium supplement and cardioprotective agent), diuretics such as furosemide (loop diuretic).

Prevalence: How common the health condition is within a specific population.
Rare in the general population; more common in individuals with chronic kidney disease or excessive magnesium intake.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Renal failure, use of magnesium-containing antacids or laxatives, and intravenous magnesium therapy.

Prognosis: The expected outcome or course of the condition over time.
Excellent with prompt treatment, but severe cases can lead to life-threatening complications.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Cardiac arrest, respiratory failure, and neuromuscular dysfunction.

Hypomagnesemia

Specialty: Nephrology

Category: Electrolyte and Acid-Base Disorders

Symptoms:
muscle cramps; tremors; weakness; fatigue; nausea; vomiting; irritability; confusion; seizures; cardiac arrhythmias (e.g., prolonged qt interval)

Root Cause:
Low magnesium levels in the blood due to inadequate dietary intake, increased excretion via kidneys or gastrointestinal tract, or certain medications.

How it's Diagnosed: videos
Blood tests measuring serum magnesium levels; additional evaluations may include kidney function tests and assessment of other electrolytes (e.g., calcium and potassium).

Treatment:
Address underlying causes, magnesium supplementation (oral or intravenous), and correction of associated electrolyte imbalances.

Medications:
Magnesium supplements, such as magnesium oxide (oral) or magnesium sulfate (IV for severe cases). These are electrolyte supplements.

Prevalence: How common the health condition is within a specific population.
Common in hospitalized patients (up to 10%–20%) and in individuals with chronic illnesses.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Chronic alcoholism, malnutrition, gastrointestinal disorders (e.g., Crohn’s disease), diuretics, proton pump inhibitors, and diabetes.

Prognosis: The expected outcome or course of the condition over time.
Generally good with timely diagnosis and treatment, but prolonged or severe cases can lead to significant complications if untreated.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Cardiac arrhythmias, seizures, muscle paralysis, and refractory hypocalcemia or hypokalemia.

Somatostatinoma

Specialty: Diabetes and Endocrinology

Category: Pancreatic Endocrine Disorders

Symptoms:
diabetes; gallstones; steatorrhea (fatty stools); abdominal pain; weight loss; diarrhea; nausea

Root Cause:
Overproduction of somatostatin, usually due to a rare neuroendocrine tumor in the pancreas or duodenum, leading to inhibition of other hormone secretions.

How it's Diagnosed: videos
Blood tests (elevated somatostatin levels), imaging studies (CT, MRI, or octreotide scans), and biopsy of the tumor.

Treatment:
Surgical resection of the tumor, somatostatin analogs for symptom control, and supportive therapy for nutritional issues.

Medications:
Somatostatin analogs such as octreotide or lanreotide may be used to manage symptoms.

Prevalence: How common the health condition is within a specific population.
Extremely rare; incidence is estimated to be less than 1 per million people annually.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Often sporadic but may be associated with genetic syndromes like MEN1 or von Hippel-Lindau disease.

Prognosis: The expected outcome or course of the condition over time.
Variable; early detection and treatment improve outcomes, but metastatic disease has a poor prognosis.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Metastasis, severe malnutrition due to malabsorption, and hormonal imbalances.

Esophagitis

Specialty: Gastrointestinal

Category: Esophageal Disorders

Sub-category: Inflammatory and Infectious Disorders

Symptoms:
pain or difficulty swallowing; chest pain; heartburn; regurgitation; nausea; vomiting; sore throat

Root Cause:
Inflammation of the esophageal lining caused by acid reflux, infections, medications, or allergies.

How it's Diagnosed: videos
Endoscopy with biopsy, barium swallow studies, and laboratory tests for infectious causes.

Treatment:
Addressing the underlying cause, acid suppression therapy, treating infections with appropriate medications, and dietary modifications.

Medications:
Proton pump inhibitors (PPIs) like pantoprazole for acid suppression; antifungals like fluconazole for fungal infections; antivirals like acyclovir for herpes esophagitis; corticosteroids for eosinophilic esophagitis.

Prevalence: How common the health condition is within a specific population.
Common; varies depending on the underlying cause (e.g., GERD-related esophagitis affects millions).

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
GERD, immunosuppression, prolonged medication use, food allergies, and certain infections.

Prognosis: The expected outcome or course of the condition over time.
Generally good with appropriate treatment; untreated cases can lead to complications.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Strictures, ulcers, bleeding, and perforation in severe cases.

Infectious Esophagitis

Specialty: Gastrointestinal

Category: Esophageal Disorders

Sub-category: Inflammatory and Infectious Disorders

Symptoms:
painful swallowing; difficulty swallowing; chest pain; fever in some cases; nausea

Root Cause:
Infections of the esophagus, commonly caused by Candida species, herpes simplex virus (HSV), or cytomegalovirus (CMV) in immunocompromised individuals.

How it's Diagnosed: videos
Endoscopy with biopsy and culture, polymerase chain reaction (PCR) tests for viral pathogens.

Treatment:
Antimicrobial or antiviral therapy, depending on the causative agent.

Medications:
Antifungals like fluconazole for Candida ; antivirals such as acyclovir for HSV and ganciclovir for CMV.

Prevalence: How common the health condition is within a specific population.
Common among immunocompromised patients, such as those with HIV/AIDS, cancer, or organ transplants.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Immunosuppression, prolonged corticosteroid use, and uncontrolled diabetes.

Prognosis: The expected outcome or course of the condition over time.
Good with treatment; delayed therapy can lead to complications.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Perforation, strictures, and dissemination of the infection.

Gastritis (Acute and Chronic)

Specialty: Gastrointestinal

Category: Stomach Disorders

Sub-category: Inflammatory Disorders

Symptoms:
abdominal pain; nausea; vomiting; loss of appetite; bloating; belching; indigestion; dark stools (if bleeding occurs)

Root Cause:
Inflammation of the stomach lining caused by factors such as Helicobacter pylori infection, excessive alcohol consumption, NSAID use, or autoimmune disorders.

How it's Diagnosed: videos
Through patient history, physical examination, endoscopy with biopsy, and testing for H. pylori (urea breath test, stool antigen test, or blood antibody test).

Treatment:
Addressing the underlying cause (e.g., H. pylori eradication, reducing NSAID use), lifestyle modifications, and symptomatic relief.

Medications:
Proton pump inhibitors (PPIs) like omeprazole or lansoprazole to reduce stomach acid. H2-receptor antagonists such as ranitidine or famotidine to reduce acid production. Antibiotics (if H. pylori is present) like amoxicillin , clarithromycin , and metronidazole for bacterial eradication. Antacids for temporary relief of symptoms.

Prevalence: How common the health condition is within a specific population.
Common worldwide; chronic gastritis is prevalent in up to 50% of the global population, with higher rates in developing countries due to H. pylori.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Chronic H. pylori infection, long-term NSAID use, excessive alcohol intake, smoking, stress, autoimmune conditions, older age.

Prognosis: The expected outcome or course of the condition over time.
Good with appropriate treatment; acute cases often resolve quickly, while chronic cases require ongoing management to prevent complications.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Peptic ulcers, gastric bleeding, anemia, increased risk of gastric cancer (especially in chronic cases linked to H. pylori).

Helicobacter pylori Infection

Specialty: Gastrointestinal

Category: Stomach Disorders

Sub-category: Bacterial Infections

Symptoms:
upper abdominal pain; nausea; bloating; loss of appetite; frequent burping; unintentional weight loss; dark stools (if ulcers or bleeding occur)

Root Cause:
Infection of the stomach lining with H. pylori bacteria, which disrupts the protective mucosal barrier and induces inflammation.

How it's Diagnosed: videos
Urea breath test, stool antigen test, blood antibody test, or endoscopy with biopsy for histology, urease testing, or PCR.

Treatment:
Eradication therapy with a combination of antibiotics and acid-suppressing medications.

Medications:
Antibiotics such as amoxicillin , clarithromycin , and metronidazole or levofloxacin (used in combination for eradication therapy). Proton pump inhibitors (PPIs) like omeprazole or esomeprazole to reduce stomach acid and enhance antibiotic effectiveness. Bismuth-containing compounds (e.g., bismuth subsalicylate ) in quadruple therapy regimens.

Prevalence: How common the health condition is within a specific population.
Affects approximately 50% of the global population, with higher prevalence in developing countries.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Poor sanitation, contaminated food or water, close contact with infected individuals, living in crowded or resource-limited settings.

Prognosis: The expected outcome or course of the condition over time.
Excellent if treated promptly; eradication significantly reduces the risk of gastritis, peptic ulcers, and gastric cancer.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Chronic gastritis, peptic ulcer disease, gastric mucosa-associated lymphoid tissue (MALT) lymphoma, increased risk of gastric cancer.

Gastroparesis (Delayed Gastric Emptying)

Specialty: Gastrointestinal

Category: Stomach Disorders

Sub-category: Structural and Functional Disorders

Symptoms:
nausea; vomiting; bloating; early satiety; abdominal pain; unintentional weight loss; heartburn

Root Cause:
Impaired motility of the stomach muscles prevents proper emptying of stomach contents into the small intestine, often associated with vagus nerve damage or autonomic dysfunction.

How it's Diagnosed: videos
Diagnosed through gastric emptying studies (scintigraphy), upper gastrointestinal (GI) endoscopy to rule out obstruction, and breath tests (e.g., carbon-labeled meal breath test).

Treatment:
Dietary changes (small, low-fat meals), medications to improve gastric motility, and in severe cases, gastric electrical stimulation or feeding tubes.

Medications:
Metoclopramide (dopamine antagonist) is often prescribed to improve stomach contractions. Domperidone (dopamine antagonist) is another option available in some regions. Erythromycin (macrolide antibiotic) can enhance gastric motility as a side effect. Antiemetics such as ondansetron or promethazine may be used to manage nausea.

Prevalence: How common the health condition is within a specific population.
Affects approximately 0.2% of the general population; higher prevalence among individuals with diabetes or post-surgical complications.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Diabetes mellitus, prior gastric surgery, systemic diseases like scleroderma, infections, and certain medications (e.g., opioids, anticholinergics).

Prognosis: The expected outcome or course of the condition over time.
Varies; many cases improve with dietary changes and medications, but severe cases may lead to malnutrition and require surgical interventions.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Malnutrition, dehydration, bezoars (hardened masses of undigested food), and severe weight loss.

Gastric Outlet Obstruction

Specialty: Gastrointestinal

Category: Stomach Disorders

Sub-category: Structural and Functional Disorders

Symptoms:
nausea; vomiting (often projectile); abdominal bloating; early satiety; unintentional weight loss; upper abdominal pain

Root Cause:
Blockage at the pylorus or first part of the duodenum due to peptic ulcers, tumors, scarring, or inflammation, leading to impaired gastric emptying.

How it's Diagnosed: videos
Diagnosed using upper GI endoscopy, contrast-enhanced X-rays (barium swallow), or abdominal CT scans to identify the cause of obstruction.

Treatment:
Endoscopic dilation of the obstruction, medications to reduce inflammation (e.g., proton pump inhibitors for ulcer-related obstructions), and surgical interventions (e.g., gastrojejunostomy).

Medications:
Proton pump inhibitors (PPIs) like omeprazole or pantoprazole are used for ulcer healing. Antiemetics such as ondansetron may address nausea. Antibiotics might be necessary if Helicobacter pylori infection is involved.

Prevalence: How common the health condition is within a specific population.
Uncommon in the general population but seen in individuals with untreated peptic ulcers or gastric tumors.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Chronic NSAID use, untreated H. pylori infection, gastric tumors, and prior gastric surgeries.

Prognosis: The expected outcome or course of the condition over time.
Generally favorable if the underlying cause is identified and treated; untreated obstructions can lead to severe dehydration and malnutrition.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Malnutrition, severe dehydration, metabolic alkalosis from repeated vomiting, and gastric perforation if untreated.

Gastric Ulcers

Specialty: Gastrointestinal

Category: Stomach Disorders

Sub-category: Peptic Ulcer Disease

Symptoms:
burning or gnawing pain in the stomach; bloating; nausea; vomiting; loss of appetite; unexplained weight loss; dark or black stools (indicating bleeding); vomiting blood or coffee-ground-like material

Root Cause:
Gastric ulcers are sores that develop on the stomach lining due to the breakdown of the protective mucosal layer, often caused by Helicobacter pylori infection or the prolonged use of NSAIDs.

How it's Diagnosed: videos
Endoscopy (esophagogastroduodenoscopy), biopsy during endoscopy to check for H. pylori, urea breath test, stool antigen test, and blood tests for anemia.

Treatment:
Eradication of H. pylori infection if present, reduction of stomach acid production, lifestyle modifications (dietary changes, smoking cessation), and avoidance of NSAIDs.

Medications:
Proton pump inhibitors (PPIs) like omeprazole , pantoprazole , or esomeprazole reduce stomach acid production. H2 receptor blockers such as ranitidine or famotidine are used for acid reduction. Antibiotics like clarithromycin , amoxicillin , and metronidazole for H. pylori eradication. Antacids and cytoprotective agents like sucralfate or bismuth subsalicylate to protect the stomach lining.

Prevalence: How common the health condition is within a specific population.
Gastric ulcers affect approximately 5-10% of the global population during their lifetime, with higher rates in individuals over 60 years of age.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
H. pylori infection, chronic NSAID use, smoking, alcohol consumption, high-stress levels, and a family history of peptic ulcers.

Prognosis: The expected outcome or course of the condition over time.
With appropriate treatment, most gastric ulcers heal within 6-8 weeks. Eradicating H. pylori significantly reduces the recurrence rate.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Bleeding, perforation of the stomach wall, penetration into adjacent organs, gastric outlet obstruction, and increased risk of stomach cancer.

Duodenal Ulcers

Specialty: Gastrointestinal

Category: Stomach Disorders

Sub-category: Peptic Ulcer Disease

Symptoms:
burning stomach pain that improves with eating or drinking; bloating; belching; nausea; vomiting; loss of appetite; unexplained weight loss; dark or tarry stools; vomiting blood or material resembling coffee grounds

Root Cause:
Duodenal ulcers are sores in the lining of the first part of the small intestine, commonly caused by H. pylori infection or chronic NSAID use, leading to acid-related damage.

How it's Diagnosed: videos
Endoscopy, urea breath test, stool antigen test, and biopsy for H. pylori detection; blood tests may also identify anemia associated with bleeding ulcers.

Treatment:
Treatment involves acid suppression, eradication of H. pylori, lifestyle changes, and avoiding irritants like NSAIDs.

Medications:
Proton pump inhibitors (PPIs) such as omeprazole or lansoprazole reduce acid secretion. Antibiotics like clarithromycin , amoxicillin , and metronidazole are used to treat H. pylori infection. H2 receptor blockers such as ranitidine or famotidine provide acid reduction. Cytoprotective agents like sucralfate and bismuth subsalicylate enhance mucosal protection.

Prevalence: How common the health condition is within a specific population.
Duodenal ulcers are more common than gastric ulcers, with a lifetime prevalence of approximately 10-15%, particularly among younger adults and males.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
H. pylori infection, NSAID use, smoking, high-stress levels, excessive alcohol consumption, and a family history of peptic ulcers.

Prognosis: The expected outcome or course of the condition over time.
Most duodenal ulcers heal within 4-6 weeks with appropriate treatment. H. pylori eradication substantially reduces recurrence.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Bleeding, perforation, penetration into adjacent organs, duodenal obstruction, and rarely an increased risk of cancer in the duodenum.

Gastric Adenocarcinoma

Specialty: Gastrointestinal

Category: Stomach Disorders

Sub-category: Stomach Cancer

Symptoms:
abdominal pain; unexplained weight loss; nausea; vomiting; loss of appetite; early satiety; blood in stool; fatigue

Root Cause:
Malignant transformation of the gastric mucosal cells, often associated with chronic inflammation, H. pylori infection, genetic predisposition, or dietary carcinogens.

How it's Diagnosed: videos
Endoscopy with biopsy, imaging studies (CT scan, MRI, PET), blood tests for tumor markers (e.g., CEA, CA 19-9), and staging procedures.

Treatment:
Surgical resection (gastrectomy), chemotherapy, radiation therapy, targeted therapy (e.g., HER2 inhibitors for HER2-positive tumors).

Medications:
Treatment may include chemotherapy drugs such as 5-fluorouracil (5-FU) (antimetabolite), cisplatin (platinum-based alkylating agent), and trastuzumab (HER2-targeted monoclonal antibody) for HER2-positive cases.

Prevalence: How common the health condition is within a specific population.
One of the most common types of stomach cancer, with higher rates in East Asia, Eastern Europe, and South America.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
H. pylori infection, smoking, high salt intake, diet low in fruits and vegetables, chronic gastritis, family history of gastric cancer, genetic syndromes (e.g., Lynch syndrome).

Prognosis: The expected outcome or course of the condition over time.
Prognosis depends on the stage at diagnosis; early detection improves survival rates significantly, but advanced cases have poorer outcomes.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Metastasis to other organs (liver, lungs, peritoneum), gastrointestinal bleeding, obstruction, and malnutrition.

Gastrointestinal Stromal Tumors (GISTs)

Specialty: Gastrointestinal

Category: Stomach Disorders

Sub-category: Stomach Tumors

Symptoms:
abdominal pain; gastrointestinal bleeding; early satiety; nausea; vomiting; unexplained weight loss

Root Cause:
Tumors arising from the interstitial cells of Cajal in the gastrointestinal tract, often due to mutations in the KIT or PDGFRA genes.

How it's Diagnosed: videos
Endoscopy, biopsy with immunohistochemistry (testing for KIT/CD117 positivity), CT scan, MRI, and PET scan for staging.

Treatment:
Surgical resection for localized tumors, tyrosine kinase inhibitors (TKIs) like imatinib for advanced or metastatic cases.

Medications:
Imatinib (a tyrosine kinase inhibitor) is the first-line treatment for advanced or metastatic GISTs. Other options include sunitinib and regorafenib for imatinib-resistant cases.

Prevalence: How common the health condition is within a specific population.
Relatively rare, accounting for less than 1% of gastrointestinal cancers, with a higher incidence in adults over 50.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Family history of GISTs, genetic mutations, age over 50, and association with neurofibromatosis type 1 (NF1).

Prognosis: The expected outcome or course of the condition over time.
Excellent prognosis for localized GISTs treated surgically; variable outcomes for advanced cases depending on response to TKI therapy.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Tumor rupture, peritoneal spread, liver metastases, and gastrointestinal obstruction or perforation.

Lymphoma of the Stomach

Specialty: Gastrointestinal

Category: Stomach Disorders

Sub-category: Stomach Lymphomas

Symptoms:
abdominal pain; bloating; weight loss; nausea; vomiting; fatigue; fever; night sweats; loss of appetite

Root Cause:
Malignant proliferation of lymphoid tissue in the stomach, often linked to chronic H. pylori infection or immune suppression.

How it's Diagnosed: videos
Endoscopy with biopsy, histopathology, immunohistochemistry, imaging (CT, PET scan), and bone marrow biopsy for staging.

Treatment:
Eradication of H. pylori with antibiotics if associated, chemotherapy, radiation therapy, immunotherapy (e.g., rituximab), or a combination depending on the lymphoma type.

Medications:
Antibiotics (for H. pylori-associated cases, e.g., amoxicillin and clarithromycin ), rituximab (CD20 monoclonal antibody), and chemotherapy agents like cyclophosphamide , doxorubicin , vincristine , and prednisone (CHOP regimen).

Prevalence: How common the health condition is within a specific population.
Represents less than 5% of all stomach cancers, with a higher prevalence in individuals with chronic H. pylori infection.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
H. pylori infection, autoimmune disorders, immunosuppression, and family history of lymphoma.

Prognosis: The expected outcome or course of the condition over time.
Varies by type and stage; early-stage cases have a good prognosis, particularly with H. pylori eradication, while advanced cases depend on response to chemotherapy.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Gastrointestinal bleeding, obstruction, perforation, and spread to lymph nodes or other organs.

Zollinger-Ellison Syndrome (Gastrinoma)

Specialty: Gastrointestinal

Category: Other Stomach Conditions

Sub-category: Stomach Cancer

Symptoms:
abdominal pain; diarrhea; nausea; vomiting; weight loss; heartburn; gastric ulcers; gastrointestinal bleeding

Root Cause:
Excessive secretion of gastrin due to a gastrin-secreting tumor (gastrinoma), leading to increased stomach acid production.

How it's Diagnosed: videos
Blood tests to measure gastrin levels, secretin stimulation test, imaging studies (CT, MRI, or somatostatin receptor scintigraphy) to locate gastrinoma, and endoscopic examination.

Treatment:
Proton pump inhibitors (PPIs) to reduce acid production, surgical removal of the gastrinoma, and chemotherapy or targeted therapy for metastatic disease.

Medications:
Proton pump inhibitors (e.g., omeprazole or esomeprazole ) to reduce gastric acid secretion; somatostatin analogs (e.g., octreotide ) to inhibit gastrin release; chemotherapeutic agents (e.g., streptozocin and doxorubicin ) for advanced cases.

Prevalence: How common the health condition is within a specific population.
Rare; occurs in approximately 1–3 individuals per million annually.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Associated with multiple endocrine neoplasia type 1 (MEN1), family history of endocrine tumors.

Prognosis: The expected outcome or course of the condition over time.
Varies; curable if localized gastrinoma is surgically removed, but prognosis worsens with metastatic disease.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Peptic ulcers, perforation of the stomach or intestines, gastrointestinal bleeding, severe diarrhea, and malnutrition.

Menetrier’s Disease (Hypertrophic Gastropathy)

Specialty: Gastrointestinal

Category: Other Stomach Conditions

Sub-category: Stomach Cancer

Symptoms:
nausea; vomiting; epigastric pain; diarrhea; anorexia; weight loss; edema due to protein loss

Root Cause:
Overgrowth of the stomach’s mucosal lining, leading to large gastric folds, protein loss, and reduced acid production.

How it's Diagnosed: videos
Endoscopy with biopsy of stomach tissue, barium swallow test, serum albumin levels to assess protein loss, and imaging to identify gastric wall thickening.

Treatment:
Symptomatic management, nutritional support, proton pump inhibitors, and sometimes total gastrectomy in severe cases.

Medications:
Proton pump inhibitors (e.g., pantoprazole or lansoprazole ) to reduce gastric secretion; cetuximab , a monoclonal antibody targeting epidermal growth factor receptor (EGFR), has shown promise in some cases.

Prevalence: How common the health condition is within a specific population.
Extremely rare; incidence is not well-documented.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Unknown, though some cases are linked to cytomegalovirus (CMV) infection in children or H. pylori infection in adults.

Prognosis: The expected outcome or course of the condition over time.
Variable; some cases resolve spontaneously, while others progress and require surgical intervention.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Severe protein loss leading to hypoalbuminemia, gastric adenocarcinoma, malnutrition, and fluid retention (edema).

Giardiasis

Specialty: Infectious Diseases

Category: Gastrointestinal Tract and Intra-abdominal Infections

Symptoms:
watery diarrhea; greasy, foul-smelling stools; abdominal cramps; bloating; nausea; fatigue; weight loss

Root Cause:
Protozoan parasite Giardia lamblia infects the small intestine, often transmitted via contaminated water, food, or contact with infected individuals.

How it's Diagnosed: videos
Stool tests for Giardia antigens, microscopic examination of stool samples, or molecular tests like PCR.

Treatment:
Antiparasitic medications, hydration, and supportive care.

Medications:
Metronidazole (nitroimidazole antibiotic), Tinidazole (similar to metronidazole , also a nitroimidazole), or Nitazoxanide (antiprotozoal agent).

Prevalence: How common the health condition is within a specific population.
Common in developing countries; in the U.S., Giardia is a leading cause of waterborne outbreaks of diarrhea.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Consuming contaminated water (e.g., from lakes or streams), poor sanitation, travel to endemic areas, and close contact with infected individuals.

Prognosis: The expected outcome or course of the condition over time.
Excellent with treatment; without treatment, symptoms can persist or become chronic.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Chronic diarrhea, malabsorption, weight loss, and in severe cases, growth retardation in children.

Small Bowel Adenocarcinoma

Specialty: Gastrointestinal

Category: Small Intestine Disorders

Sub-category: Tumors

Symptoms:
abdominal pain; nausea; vomiting; unexplained weight loss; intestinal obstruction; anemia; blood in stool

Root Cause:
Uncontrolled growth of malignant epithelial cells originating in the small intestine, often due to genetic mutations or chronic inflammation.

How it's Diagnosed: videos
Imaging studies (CT scans, MRI, PET scans), endoscopy, biopsy, blood tests (including tumor markers like CEA or CA19-9).

Treatment:
Surgery to remove the tumor, chemotherapy, and in some cases, targeted therapy.

Medications:
Chemotherapy drugs such as 5-fluorouracil (antimetabolite), oxaliplatin (platinum-based agent), or capecitabine (oral antimetabolite). Targeted therapies like pembrolizumab (immune checkpoint inhibitor) may also be used.

Prevalence: How common the health condition is within a specific population.
Rare, accounting for approximately 3-5% of gastrointestinal cancers and less than 1% of all cancers.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Family history of gastrointestinal cancers, genetic syndromes (e.g., Lynch syndrome, familial adenomatous polyposis), chronic inflammation (e.g., Crohn’s disease), and diet high in red or processed meat.

Prognosis: The expected outcome or course of the condition over time.
Varies by stage; localized tumors have a better prognosis (5-year survival rate ~65%), while advanced/metastatic disease has a poor prognosis (~10-20% 5-year survival).

Complications: Additional problems or conditions that may arise as a result of the original condition.
Intestinal obstruction, perforation, metastasis to the liver or lymph nodes, and paraneoplastic syndromes.

Lymphoma of the Small Intestine

Specialty: Gastrointestinal

Category: Small Intestine Disorders

Sub-category: Tumors

Symptoms:
abdominal pain; nausea; weight loss; diarrhea; intestinal obstruction; fever; night sweats

Root Cause:
Malignant proliferation of lymphocytes in the small intestine, often associated with immune dysregulation or infections.

How it's Diagnosed: videos
Endoscopic biopsy, imaging (CT scans, PET scans), blood tests, bone marrow biopsy, and immunophenotyping.

Treatment:
Chemotherapy, radiation therapy, and immunotherapy; surgery may be required in some cases of localized disease.

Medications:
Chemotherapy agents like CHOP regimen (cyclophosphamide , doxorubicin , vincristine , prednisone ), and monoclonal antibodies such as rituximab (anti-CD20 agent).

Prevalence: How common the health condition is within a specific population.
Rare; accounts for 1-4% of gastrointestinal malignancies and 30-40% of primary gastrointestinal lymphomas.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Immunodeficiency (e.g., HIV/AIDS, post-transplant), chronic inflammatory diseases (e.g., celiac disease), and infections (e.g., Helicobacter pylori, Epstein-Barr virus).

Prognosis: The expected outcome or course of the condition over time.
Depends on subtype and stage; indolent types have a good prognosis (5-year survival rate ~80%), while aggressive types have lower survival rates (~30-50%).

Complications: Additional problems or conditions that may arise as a result of the original condition.
Intestinal perforation, obstruction, bleeding, malabsorption, and systemic spread to other lymphoid or non-lymphoid tissues.

Clostridium difficile Infection

Specialty: Gastrointestinal

Category: Large Intestine (Colon) Disorders

Sub-category: Infectious Disorders

Symptoms:
watery diarrhea; abdominal pain or cramping; fever; nausea; loss of appetite; weight loss; fatigue; blood or pus in stool in severe cases

Root Cause:
Overgrowth of Clostridium difficile bacteria in the colon, often after disruption of normal gut flora due to antibiotic use. This leads to toxin production and colonic inflammation.

How it's Diagnosed: videos
Stool tests for C. difficile toxins (toxin A and B), PCR assays for toxin genes, and enzyme immunoassays; sometimes colonoscopy or imaging studies if complications are suspected.

Treatment:
Discontinuation of the offending antibiotic, initiating specific antibiotic therapy targeting C. difficile, fluid replacement for dehydration, probiotics, and in severe cases, fecal microbiota transplantation (FMT).

Medications:
Vancomycin (oral) or fidaxomicin are the primary treatments; metronidazole may be used in mild cases. Vancomycin and fidaxomicin are antibiotics specifically targeting C. difficile. Bezlotoxumab , a monoclonal antibody, may be used to reduce recurrence in high-risk patients.

Prevalence: How common the health condition is within a specific population.
Most common cause of healthcare-associated diarrhea; approximately 500,000 cases annually in the U.S.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Recent antibiotic use, hospitalization, advanced age, weakened immune system, gastrointestinal surgery, or a history of C. difficile infection.

Prognosis: The expected outcome or course of the condition over time.
With prompt treatment, most recover fully; however, recurrent infections occur in about 20% of patients. Severe cases can lead to complications, such as toxic megacolon or death.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Recurrence, dehydration, toxic megacolon, bowel perforation, sepsis, and death in severe cases.

Infectious Colitis (e.g., Viral, Bacterial, Parasitic)

Specialty: Gastrointestinal

Category: Large Intestine (Colon) Disorders

Sub-category: Infectious Disorders

Symptoms:
diarrhea (often with blood or mucus); abdominal pain; fever; nausea; vomiting; fatigue; dehydration; weight loss

Root Cause:
Infection of the colon by pathogens such as bacteria (e.g., Salmonella, Shigella, E. coli, Campylobacter), viruses (e.g., norovirus, rotavirus), or parasites (e.g., Entamoeba histolytica, Giardia). This leads to inflammation and damage to the intestinal lining.

How it's Diagnosed: videos
Stool tests for pathogens (culture, PCR, or antigen detection), blood tests for inflammatory markers, and colonoscopy in chronic or severe cases to assess mucosal damage.

Treatment:
Supportive care (hydration, electrolyte replacement) and pathogen-specific treatment. Antibiotics for bacterial infections, antiparasitic medications for parasitic infections, and sometimes antiviral therapy for severe viral infections.

Medications:
Antibiotics like ciprofloxacin or azithromycin for bacterial infections; metronidazole or tinidazole for parasitic infections like Giardia or Entamoeba; oral rehydration salts for dehydration. Antibiotics are categorized as antimicrobials, while antiparasitic drugs target protozoa.

Prevalence: How common the health condition is within a specific population.
Infectious colitis is a common cause of diarrhea worldwide, with bacterial pathogens accounting for 85% of foodborne outbreaks in developed countries.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Contaminated food or water, international travel, poor hygiene, immunosuppression, and exposure to infected individuals.

Prognosis: The expected outcome or course of the condition over time.
Most cases resolve within days to weeks with appropriate treatment, but severe infections can lead to prolonged illness or death, particularly in vulnerable populations.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Dehydration, electrolyte imbalances, hemolytic uremic syndrome (HUS, associated with E. coli O157:H7), chronic post-infectious irritable bowel syndrome, and intestinal perforation.

Viral Hepatitis (A, B, C, D, E)

Specialty: Gastrointestinal

Category: Liver Disorders

Sub-category: Hepatitis

Symptoms:
jaundice; fatigue; abdominal pain; nausea; vomiting; loss of appetite; dark urine; pale stools

Root Cause:
Infection of the liver caused by hepatitis viruses (A, B, C, D, or E), leading to liver inflammation and, in some cases, chronic liver disease.

How it's Diagnosed: videos
Blood tests to identify viral markers (e.g., HBsAg, anti-HCV, anti-HAV), liver function tests, imaging studies like ultrasound, and sometimes liver biopsy.

Treatment:
Treatment depends on the type of hepatitis. Includes antiviral medications, supportive care (hydration, rest), and, in severe cases, liver transplantation.

Medications:
Hepatitis B - Tenofovir (antiviral, nucleotide analog), Entecavir (antiviral, nucleoside analog). Hepatitis C - Sofosbuvir and Velpatasvir (direct-acting antiviral agents). Hepatitis A & E - No specific antiviral treatment; supportive care. Hepatitis D - Pegylated interferon-alpha (antiviral, immune modulator).

Prevalence: How common the health condition is within a specific population.
Affects millions globally; Hepatitis B and C are the most common chronic forms, with over 250 million and 70 million people affected worldwide, respectively.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Unprotected sex, intravenous drug use, sharing needles, blood transfusions, close contact with infected individuals, and poor sanitation.

Prognosis: The expected outcome or course of the condition over time.
Acute hepatitis often resolves with supportive care, but chronic hepatitis (especially B and C) can lead to cirrhosis, liver failure, or hepatocellular carcinoma if untreated.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Chronic liver disease, cirrhosis, liver cancer, and liver failure.

Alcoholic Hepatitis

Specialty: Infectious Diseases

Category: Gastrointestinal Tract and Intra-abdominal Infections

Symptoms:
jaundice; abdominal pain; nausea; vomiting; fever; weight loss; fatigue; anorexia

Root Cause:
Inflammation and liver cell damage caused by prolonged and excessive alcohol consumption leading to toxic metabolites.

How it's Diagnosed: videos
Clinical history of alcohol use, physical examination, liver function tests (elevated AST, ALT, and bilirubin levels), imaging (ultrasound/CT), and sometimes liver biopsy.

Treatment:
Cessation of alcohol, nutritional support, corticosteroids (for severe cases), and addressing complications like infections or ascites.

Medications:
Medications include corticosteroids (e.g., prednisolone ), which reduce inflammation; pentoxifylline , a phosphodiesterase inhibitor that may prevent complications like hepatorenal syndrome. Vitamin supplementation (e.g., thiamine and folate) is often provided for nutritional deficiencies.

Prevalence: How common the health condition is within a specific population.
Alcoholic hepatitis is most common in individuals with a history of chronic alcohol use, with a prevalence of approximately 1–2% of heavy drinkers annually.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Chronic heavy alcohol consumption, malnutrition, genetic predisposition, female gender (higher susceptibility), obesity, and prior liver disease.

Prognosis: The expected outcome or course of the condition over time.
Varies with severity; mild cases may recover with alcohol cessation, while severe cases have a high mortality rate without intervention.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Liver cirrhosis, portal hypertension, ascites, hepatic encephalopathy, and increased risk of infections.

Alcoholic Cirrhosis

Specialty: Gastrointestinal

Category: Liver Disorders

Sub-category: Liver Cirrhosis

Symptoms:
fatigue; jaundice (yellowing of skin and eyes); abdominal swelling (ascites); loss of appetite; nausea; easy bruising or bleeding; spider angiomas (small, spider-like blood vessels visible under the skin); confusion or drowsiness (hepatic encephalopathy); dark urine; pale stools

Root Cause:
Chronic alcohol abuse damages liver cells, leading to scarring (fibrosis) and loss of liver function.

How it's Diagnosed: videos
Diagnosis involves medical history review (alcohol consumption), physical examination, blood tests (liver function tests, INR, bilirubin), imaging studies (ultrasound, CT, or MRI), and possibly a liver biopsy to confirm.

Treatment:
Treatment focuses on abstinence from alcohol, nutritional support, managing complications (e.g., ascites, hepatic encephalopathy), and, in severe cases, liver transplantation.

Medications:
Medications include diuretics (e.g., spironolactone or furosemide ) to manage fluid retention, lactulose or rifaximin to treat hepatic encephalopathy, and vitamin supplementation (thiamine , folate, vitamin D) to address deficiencies.

Prevalence: How common the health condition is within a specific population.
Alcoholic cirrhosis affects approximately 10–15% of heavy drinkers and accounts for around 50% of cirrhosis cases globally.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Chronic heavy alcohol consumption, genetic predisposition, malnutrition, co-existing liver diseases (e.g., hepatitis C).

Prognosis: The expected outcome or course of the condition over time.
Prognosis depends on alcohol abstinence and severity at diagnosis. Without abstinence, survival is often less than 5 years. Early abstinence improves outcomes.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Portal hypertension, variceal bleeding, hepatic encephalopathy, liver failure, spontaneous bacterial peritonitis, hepatocellular carcinoma (liver cancer).

Cirrhosis from Hepatitis or Fatty Liver Disease

Specialty: Gastrointestinal

Category: Liver Disorders

Sub-category: Liver Cirrhosis

Symptoms:
fatigue; jaundice; abdominal swelling; loss of appetite; nausea; easy bruising or bleeding; confusion or drowsiness; dark urine; pale stools

Root Cause:
Chronic inflammation from hepatitis B, hepatitis C, or non-alcoholic fatty liver disease (NAFLD) leads to progressive fibrosis and cirrhosis.

How it's Diagnosed: videos
Blood tests for liver function, viral hepatitis markers, imaging (ultrasound, transient elastography), and sometimes a liver biopsy for fibrosis grading.

Treatment:
Antiviral medications for hepatitis (e.g., entecavir or tenofovir for HBV; direct-acting antivirals for HCV), weight loss and diabetes management for NAFLD, and supportive care for complications.

Medications:
Antivirals (e.g., sofosbuvir , velpatasvir ), diuretics for fluid retention, lactulose or rifaximin for hepatic encephalopathy, and nutritional supplements as needed.

Prevalence: How common the health condition is within a specific population.
Cirrhosis from hepatitis or fatty liver disease is a leading cause of liver-related morbidity worldwide, with NAFLD prevalence rising due to obesity epidemics.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Chronic hepatitis B or C infection, obesity, diabetes, metabolic syndrome, heavy alcohol consumption, genetic factors.

Prognosis: The expected outcome or course of the condition over time.
Depends on the underlying cause and stage at diagnosis. With treatment of the underlying condition (e.g., hepatitis antivirals or weight management), progression can be slowed. Advanced cases may require liver transplantation.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Portal hypertension, variceal bleeding, hepatic encephalopathy, liver failure, hepatocellular carcinoma.

Benign Liver Tumors (e.g., Hemangioma, Focal Nodular Hyperplasia)

Specialty: Gastrointestinal

Category: Liver Disorders

Sub-category: Liver Tumors

Symptoms:
asymptomatic; right upper quadrant discomfort; bloating; nausea; rarely, a palpable mass

Root Cause:
Non-cancerous growths in the liver; hemangiomas are vascular malformations, and focal nodular hyperplasia is a hyperplastic response to vascular abnormalities.

How it's Diagnosed: videos
Often incidental on imaging (ultrasound, CT, or MRI), confirmed with characteristic imaging patterns; rarely requires biopsy.

Treatment:
Usually no treatment necessary; symptomatic lesions may require surgical resection or embolization.

Medications:
None typically required; treatment focuses on monitoring or surgical intervention if needed.

Prevalence: How common the health condition is within a specific population.
Hemangiomas are the most common benign liver tumors, affecting up to 5% of the population. Focal nodular hyperplasia is less common, occurring in 0.3%-3% of adults.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Female gender, use of oral contraceptives (for hepatic adenomas), underlying vascular abnormalities.

Prognosis: The expected outcome or course of the condition over time.
Excellent; benign tumors do not progress to malignancy, and most remain asymptomatic.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Rare; large hemangiomas may rupture, causing bleeding, or compress nearby structures.

Budd-Chiari Syndrome

Specialty: Gastrointestinal

Category: Liver Disorders

Sub-category: Vascular Liver Disorders

Symptoms:
abdominal pain, especially in the upper right quadrant; ascites; enlarged liver (hepatomegaly); jaundice; nausea; vomiting; swelling in the legs; fatigue

Root Cause:
Obstruction of the hepatic veins, often caused by thrombosis or compression, leading to impaired blood flow out of the liver and subsequent congestion and damage.

How it's Diagnosed: videos
Doppler ultrasound, CT scan, MRI, liver biopsy (in some cases), and blood tests to identify hypercoagulable states.

Treatment:
Addressing the underlying cause (e.g., anticoagulation for thrombosis, thrombolysis), managing complications like ascites, and restoring venous outflow via angioplasty, TIPS, or surgical shunting. Liver transplantation may be needed in severe cases.

Medications:
Anticoagulants (e.g., warfarin , heparin ) to prevent further clot formation; diuretics (e.g., spironolactone , furosemide ) for managing ascites; thrombolytic agents (e.g., tissue plasminogen activator) in selected cases.

Prevalence: How common the health condition is within a specific population.
Rare, with an estimated incidence of 1 in 100,000; more common in patients with underlying hypercoagulable conditions.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Hypercoagulable states (e.g., protein C or S deficiency, antiphospholipid syndrome), polycythemia vera, myeloproliferative disorders, oral contraceptive use, pregnancy, and liver tumors.

Prognosis: The expected outcome or course of the condition over time.
Variable, depending on the extent of liver damage and the success of treatment. Early intervention can significantly improve outcomes, but severe or untreated cases may lead to liver failure.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Liver failure, portal hypertension, ascites, hepatic encephalopathy, and death in advanced or untreated cases.

Cholelithiasis (Gallstones)

Specialty: Gastrointestinal

Category: Gallbladder and Biliary Tract Disorders

Sub-category: Gallbladder Diseases

Symptoms:
right upper abdominal pain; nausea; vomiting; jaundice; pain after fatty meals

Root Cause:
Formation of solid particles (gallstones) in the gallbladder due to an imbalance in bile components, including cholesterol, bile salts, and bilirubin.

How it's Diagnosed: videos
Abdominal ultrasound, blood tests for liver function, and imaging like CT or MRI when complications are suspected.

Treatment:
Watchful waiting for asymptomatic cases, cholecystectomy (surgical removal of the gallbladder) for symptomatic cases, or non-surgical options like oral bile acid therapy or extracorporeal shockwave lithotripsy.

Medications:
Ursodeoxycholic acid (ursodiol ) can be prescribed; it is a bile acid therapy that helps dissolve cholesterol gallstones over time.

Prevalence: How common the health condition is within a specific population.
Affects 10–15% of the adult population in developed countries; more common in women and older adults.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Female gender, obesity, rapid weight loss, high-fat diet, pregnancy, and family history.

Prognosis: The expected outcome or course of the condition over time.
Good with treatment; asymptomatic gallstones may never cause issues, while symptomatic cases resolve after gallbladder removal.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Acute cholecystitis, pancreatitis, bile duct obstruction, and gallbladder cancer in rare cases.

Cholecystitis (Inflammation of the Gallbladder)

Specialty: Gastrointestinal

Category: Gallbladder and Biliary Tract Disorders

Sub-category: Gallbladder Diseases

Symptoms:
severe upper abdominal pain; fever; nausea; vomiting; tenderness in the right upper abdomen

Root Cause:
Inflammation of the gallbladder, usually caused by gallstones blocking the cystic duct, leading to bile stasis and bacterial infection.

How it's Diagnosed: videos
Physical examination, abdominal ultrasound, blood tests indicating inflammation (e.g., elevated WBC, CRP), and imaging like HIDA scan.

Treatment:
Intravenous fluids, antibiotics for infection, pain management, and cholecystectomy (urgent or delayed based on severity).

Medications:
Antibiotics like ceftriaxone (a cephalosporin) combined with metronidazole (an anaerobic antibiotic) to treat infection. Pain management may include NSAIDs or opioids.

Prevalence: How common the health condition is within a specific population.
Common among individuals with gallstones; prevalence increases with age and in women.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Gallstones, obesity, older age, female gender, and prior episodes of biliary colic.

Prognosis: The expected outcome or course of the condition over time.
Favorable with treatment; untreated cases can lead to severe complications.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Gallbladder rupture, sepsis, emphysematous cholecystitis, and biliary peritonitis.

Acalculous Cholecystitis

Specialty: Gastrointestinal

Category: Gallbladder and Biliary Tract Disorders

Sub-category: Gallbladder Diseases

Symptoms:
right upper abdominal pain; fever; nausea; vomiting; jaundice

Root Cause:
Inflammation of the gallbladder without gallstones, often caused by critical illness, ischemia, or infection.

How it's Diagnosed: videos
Ultrasound showing gallbladder wall thickening, pericholecystic fluid, or positive HIDA scan; lab findings may show elevated liver enzymes and WBCs.

Treatment:
Supportive care with IV fluids, broad-spectrum antibiotics, and cholecystectomy or percutaneous cholecystostomy if the condition does not resolve.

Medications:
Broad-spectrum antibiotics like piperacillin-tazobactam (a beta-lactam/beta-lactamase inhibitor) to cover potential infections.

Prevalence: How common the health condition is within a specific population.
Accounts for 5–10% of all cholecystitis cases; more common in critically ill patients.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Major surgery, trauma, burns, prolonged fasting, total parenteral nutrition (TPN), and sepsis.

Prognosis: The expected outcome or course of the condition over time.
Variable; outcomes depend on underlying conditions and timely intervention.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Gallbladder gangrene, perforation, abscess formation, and systemic sepsis.

Choledocholithiasis (Bile Duct Stones)

Specialty: Gastrointestinal

Category: Gallbladder and Biliary Tract Disorders

Sub-category: Biliary Tract Disorders

Symptoms:
right upper quadrant abdominal pain; jaundice; dark urine; pale stools; nausea; vomiting; fever (if cholangitis develops)

Root Cause:
Obstruction of the bile duct by gallstones, leading to impaired bile flow.

How it's Diagnosed: videos
Blood tests (elevated bilirubin, alkaline phosphatase, and liver enzymes); imaging studies like ultrasound, MRCP (magnetic resonance cholangiopancreatography), or ERCP (endoscopic retrograde cholangiopancreatography).

Treatment:
ERCP to remove stones; in some cases, surgery or lithotripsy may be needed.

Medications:
Pain relievers (NSAIDs like ibuprofen or opioids like morphine ), antibiotics if infection is present (e.g., ciprofloxacin or metronidazole ).

Prevalence: How common the health condition is within a specific population.
Approximately 10-20% of individuals with gallstones develop bile duct stones.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
History of gallstones, older age, obesity, rapid weight loss, female sex, family history.

Prognosis: The expected outcome or course of the condition over time.
Good with timely treatment; recurrence may occur without addressing risk factors.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Cholangitis, pancreatitis, bile duct strictures, liver abscesses.

Cholangitis (Infection of the Bile Ducts)

Specialty: Gastrointestinal

Category: Gallbladder and Biliary Tract Disorders

Sub-category: Biliary Tract Disorders

Symptoms:
fever; chills; right upper quadrant abdominal pain; jaundice; dark urine; nausea; vomiting; hypotension (in severe cases)

Root Cause:
Bacterial infection due to bile duct obstruction, typically caused by stones, strictures, or tumors.

How it's Diagnosed: videos
Diagnosed through clinical signs (Charcot's triad), elevated liver function tests, imaging like ultrasound or MRCP, and sometimes blood cultures to confirm infection.

Treatment:
ERCP to relieve obstruction; broad-spectrum antibiotics (e.g., piperacillin-tazobactam, ceftriaxone, metronidazole).

Medications:
Broad-spectrum antibiotics, typically from the penicillin or cephalosporin family, combined with anti-anaerobic agents (e.g., metronidazole ); antipyretics like acetaminophen .

Prevalence: How common the health condition is within a specific population.
More common in individuals with a history of gallstones; incidence is 0.3-1.6 per 1,000 hospital admissions.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Gallstones, bile duct strictures, history of bile duct surgery, endoscopic procedures, malignancy.

Prognosis: The expected outcome or course of the condition over time.
Good with early intervention; mortality is high in untreated cases or septic shock.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Sepsis, liver abscesses, recurrent infections, secondary biliary cirrhosis.

Gallstone Pancreatitis

Specialty: Gastrointestinal

Category: Gallbladder and Biliary Tract Disorders

Sub-category: Acute and Chronic Pancreatitis

Symptoms:
severe upper abdominal pain; nausea; vomiting; fever; jaundice; pain radiating to the back

Root Cause:
Gallstones block the bile duct or pancreatic duct, causing inflammation of the pancreas.

How it's Diagnosed: videos
Blood tests (elevated lipase and amylase levels), abdominal ultrasound, CT scan, or MRCP (magnetic resonance cholangiopancreatography).

Treatment:
Hospitalization, fasting (to rest the pancreas), IV fluids, pain management, antibiotics (if infection is present), and ERCP (endoscopic retrograde cholangiopancreatography) to remove gallstones. Surgery (cholecystectomy) is performed later to prevent recurrence.

Medications:
Pain relievers (opioids like morphine or hydromorphone ), antispasmodics, and antibiotics such as piperacillin-tazobactam or ceftriaxone with metronidazole if infection is suspected.

Prevalence: How common the health condition is within a specific population.
Most common in adults with gallstones, accounting for 35–40% of acute pancreatitis cases in the U.S.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Gallstones, obesity, female sex, older age, rapid weight loss, high-fat diet.

Prognosis: The expected outcome or course of the condition over time.
Good with timely treatment; recurrence is prevented with gallstone removal. Mortality risk increases with severe or untreated cases.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Pancreatic necrosis, infection, pseudocysts, organ failure, or systemic inflammatory response syndrome (SIRS).

Alcohol-Induced Pancreatitis

Specialty: Gastrointestinal

Category: Gallbladder and Biliary Tract Disorders

Sub-category: Acute and Chronic Pancreatitis

Symptoms:
severe abdominal pain; pain radiating to the back; nausea; vomiting; weight loss; diarrhea; steatorrhea (fatty stools)

Root Cause:
Chronic alcohol consumption leads to inflammation, scarring, and dysfunction of the pancreas.

How it's Diagnosed: videos
History of alcohol use, blood tests (elevated lipase and amylase levels), imaging (CT, MRI, or ultrasound), and stool tests for fat malabsorption.

Treatment:
Abstinence from alcohol, supportive care with IV fluids, pain management, enzyme replacement therapy, nutritional support, and addressing complications.

Medications:
Pancreatic enzyme supplements (e.g., pancrelipase ), pain relievers (e.g., acetaminophen or opioids for severe cases), proton pump inhibitors (to reduce gastric acid).

Prevalence: How common the health condition is within a specific population.
Alcohol is the second most common cause of acute pancreatitis and a leading cause of chronic pancreatitis, often affecting males aged 30–50 years.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Chronic alcohol use, genetic predisposition, smoking, high-fat diet, concurrent gallstone disease.

Prognosis: The expected outcome or course of the condition over time.
Variable; improved with alcohol cessation. Chronic cases can lead to irreversible damage, diabetes, and complications.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Chronic pancreatitis, pseudocysts, diabetes mellitus, malnutrition, pancreatic cancer, or organ failure.

Pancreatic Adenocarcinoma

Specialty: Gastrointestinal

Category: Gallbladder and Biliary Tract Disorders

Sub-category: Pancreatic Tumors

Symptoms:
abdominal pain radiating to the back; unexplained weight loss; jaundice; loss of appetite; nausea; vomiting; new-onset diabetes; fatigue

Root Cause:
Malignant tumor originating from the exocrine cells of the pancreas, often associated with mutations in KRAS, p53, or SMAD4 genes. It often causes obstruction of the bile ducts or invasion of nearby tissues.

How it's Diagnosed: videos
Imaging studies like CT or MRI scans; endoscopic ultrasound (EUS) with biopsy; CA 19-9 tumor marker blood test; fine-needle aspiration biopsy

Treatment:
Array

Medications:
Chemotherapeutic agents such as gemcitabine (antimetabolite), nab-paclitaxel (microtubule inhibitor), or FOLFIRINOX (combination regimen including oxaliplatin , irinotecan , fluorouracil , and leucovorin ).

Prevalence: How common the health condition is within a specific population.
Accounts for approximately 90% of pancreatic cancers; globally, it is the 7th leading cause of cancer-related deaths.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Smoking; chronic pancreatitis; family history of pancreatic cancer; obesity; type 2 diabetes; genetic syndromes such as BRCA mutations or Lynch syndrome

Prognosis: The expected outcome or course of the condition over time.
Poor prognosis; the 5-year survival rate is approximately 10%, with earlier detection improving outcomes.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Obstruction of the bile duct or intestines; diabetes; malnutrition; metastasis to the liver or peritoneum; pain requiring intensive palliative care

Pancreatic Cysts

Specialty: Gastrointestinal

Category: Gallbladder and Biliary Tract Disorders

Sub-category: Other Pancreatic Disorders

Symptoms:
abdominal pain; nausea; vomiting; jaundice (if the cyst compresses the bile duct); unintended weight loss; palpable mass in the abdomen

Root Cause:
Fluid-filled sacs in the pancreas caused by a variety of conditions, such as pancreatitis, trauma, or neoplasms.

How it's Diagnosed: videos
Imaging studies like CT scan, MRI, or endoscopic ultrasound (EUS), combined with fine-needle aspiration for cyst fluid analysis.

Treatment:
Treatment depends on the type of cyst. Observation for benign or asymptomatic cysts, drainage, or surgical removal for symptomatic, infected, or potentially malignant cysts.

Medications:
Antibiotics like ciprofloxacin or metronidazole for infected cysts; proton pump inhibitors (PPIs) to reduce pancreatic inflammation in associated conditions.

Prevalence: How common the health condition is within a specific population.
Seen in approximately 10-20% of patients undergoing imaging for unrelated reasons; prevalence increases with age.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Acute or chronic pancreatitis, alcohol use, gallstones, abdominal trauma, family history of pancreatic cysts.

Prognosis: The expected outcome or course of the condition over time.
Generally good for benign cysts; malignant potential depends on the type (e.g., intraductal papillary mucinous neoplasm, or IPMN, has a higher risk).

Complications: Additional problems or conditions that may arise as a result of the original condition.
Risk of rupture, infection, hemorrhage, or transformation into pancreatic cancer.

Hereditary Pancreatitis

Specialty: Gastrointestinal

Category: Pancreatic Disorders

Sub-category: Genetic Pancreatic Disorders

Symptoms:
recurrent episodes of abdominal pain; nausea; vomiting; jaundice; steatorrhea; chronic fatigue; weight loss

Root Cause:
Genetic mutations (e.g., PRSS1, SPINK1, CFTR) leading to abnormal pancreatic enzyme activity and recurrent inflammation of the pancreas.

How it's Diagnosed: videos
Genetic testing, family history, imaging studies (CT or MRI), and endoscopic retrograde cholangiopancreatography (ERCP).

Treatment:
Pain management, pancreatic enzyme replacement therapy (PERT), dietary modifications, and in severe cases, total pancreatectomy with islet cell autotransplantation.

Medications:
Analgesics (acetaminophen , NSAIDs, or opioids for severe pain), pancreatic enzyme supplements, antioxidants to reduce inflammation.

Prevalence: How common the health condition is within a specific population.
Rare condition, accounting for less than 1% of chronic pancreatitis cases; higher prevalence in families with known mutations.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Positive family history, specific genetic mutations (e.g., PRSS1 mutation).

Prognosis: The expected outcome or course of the condition over time.
Variable; depends on frequency and severity of episodes. Higher risk of developing diabetes and pancreatic cancer over time.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Chronic pancreatitis, pancreatic insufficiency, diabetes mellitus, pancreatic cancer.

Gastroparesis

Specialty: Gastrointestinal

Category: General and Miscellaneous GI Conditions

Sub-category: Motility Disorders

Symptoms:
nausea; vomiting; early satiety; bloating; abdominal pain; weight loss; poor appetite

Root Cause:
Impaired gastric motility due to delayed emptying of the stomach without mechanical obstruction; often associated with nerve or muscle dysfunction.

How it's Diagnosed: videos
Gastric emptying studies (e.g., scintigraphy, breath tests), upper endoscopy to rule out obstruction, and imaging such as CT or MRI to assess anatomy.

Treatment:
Dietary modifications (small, low-fat, low-fiber meals), prokinetic medications, antiemetics, and in severe cases, interventions like gastric electrical stimulation or jejunal feeding tubes.

Medications:
Prokinetic agents such as metoclopramide (a dopamine antagonist) and erythromycin (a macrolide antibiotic) are prescribed to enhance gastric motility. Antiemetics, such as ondansetron (a serotonin 5-HT3 receptor antagonist) or promethazine (a phenothiazine derivative ), are used to control nausea and vomiting.

Prevalence: How common the health condition is within a specific population.
Affects an estimated 4% of the U.S. population, with higher prevalence in individuals with diabetes or post-surgical complications.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Diabetes mellitus (type 1 and 2), prior abdominal surgery, systemic disorders affecting nerves or muscles (e.g., Parkinson’s disease, scleroderma), and certain medications (e.g., opioids, anticholinergics).

Prognosis: The expected outcome or course of the condition over time.
Varies by severity; manageable with lifestyle changes and medications, but symptoms can persist and significantly affect quality of life.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Severe malnutrition, dehydration, bezoar formation, fluctuating blood glucose levels in diabetic patients, and impaired medication absorption.

Intestinal Pseudo-Obstruction

Specialty: Gastrointestinal

Category: General and Miscellaneous GI Conditions

Sub-category: Motility Disorders

Symptoms:
abdominal pain; bloating; nausea; vomiting; constipation; diarrhea; malnutrition; failure to thrive in children

Root Cause:
Abnormal motility of the intestines due to dysfunction of the smooth muscle or nerves; mimics a mechanical obstruction but without a physical blockage.

How it's Diagnosed: videos
Abdominal X-rays, CT scans, manometry to evaluate intestinal contractions, and full-thickness biopsies to examine underlying neuromuscular abnormalities.

Treatment:
Management focuses on treating symptoms with dietary adjustments (low-residue or elemental diets), enteral or parenteral nutrition, prokinetic agents, and in some cases, surgical decompression.

Medications:
Prokinetic agents such as neostigmine (a cholinesterase inhibitor) and metoclopramide (a dopamine antagonist) are used to enhance motility. Antispasmodics, such as hyoscine (an anticholinergic agent), may be used to manage painful cramping. Antibiotics, like rifaximin (a gut-specific antibiotic), may be prescribed for bacterial overgrowth.

Prevalence: How common the health condition is within a specific population.
Rare, with an estimated prevalence of fewer than 1 in 100,000 individuals; can occur as a primary (idiopathic) condition or secondary to systemic diseases.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Genetic predispositions, underlying conditions like scleroderma, systemic lupus erythematosus, neurological disorders, or prior abdominal surgery.

Prognosis: The expected outcome or course of the condition over time.
Chronic and often progressive; prognosis depends on the underlying cause and response to treatment. Early intervention with nutritional support can improve outcomes.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Severe malnutrition, intestinal perforation, bacterial overgrowth, sepsis, and dependency on parenteral nutrition in advanced cases.

Peritonitis (Spontaneous Bacterial or Secondary)

Specialty: Gastrointestinal

Category: General and Miscellaneous GI Conditions

Sub-category: Peritoneal Disorders

Symptoms:
abdominal pain; fever; nausea; vomiting; bloating; loss of appetite; rebound tenderness; altered mental status (in severe cases)

Root Cause:
Inflammation of the peritoneum caused by bacterial infection, either spontaneous (usually due to liver disease and ascites) or secondary to conditions like a perforated appendix or bowel injury.

How it's Diagnosed: videos
Clinical examination, imaging (CT scan or ultrasound), and diagnostic paracentesis (analysis of peritoneal fluid for white blood cell count, Gram stain, and culture).

Treatment:
Immediate treatment includes antibiotics to target causative bacteria, supportive care (IV fluids, pain management), and surgery (in secondary peritonitis) to repair the underlying source of infection.

Medications:
Broad-spectrum antibiotics such as cefotaxime or piperacillin-tazobactam (antibacterial). In cases of fungal involvement, antifungals like fluconazole may be used.

Prevalence: How common the health condition is within a specific population.
Spontaneous bacterial peritonitis occurs in 10-30% of patients with cirrhosis and ascites. Secondary peritonitis prevalence depends on underlying conditions like appendicitis or bowel perforation.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Chronic liver disease with ascites, peritoneal dialysis, abdominal surgery, gastrointestinal perforations, trauma, and immunosuppression.

Prognosis: The expected outcome or course of the condition over time.
Prognosis varies; spontaneous bacterial peritonitis has a 20-40% mortality rate, which improves with prompt treatment. Secondary peritonitis requires surgical intervention and can lead to serious complications without timely management.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Sepsis, multi-organ failure, abscess formation, and recurrent infections.

Ascites (Abdominal Fluid Accumulation)

Specialty: Gastrointestinal

Category: General and Miscellaneous GI Conditions

Sub-category: Peritoneal Disorders

Symptoms:
abdominal distension; weight gain; shortness of breath; abdominal discomfort; nausea; early satiety

Root Cause:
Accumulation of fluid in the peritoneal cavity, commonly caused by liver cirrhosis, but also associated with cancers, heart failure, or infections.

How it's Diagnosed: videos
Physical exam (shifting dullness, fluid wave test), ultrasound for fluid detection, and paracentesis to analyze the ascitic fluid (e.g., albumin gradient, cell count, cultures).

Treatment:
Management of the underlying cause (e.g., liver disease), sodium restriction, diuretics (e.g., spironolactone and furosemide), therapeutic paracentesis for symptomatic relief, and in severe cases, transjugular intrahepatic portosystemic shunt (TIPS) or liver transplant.

Medications:
Diuretics such as spironolactone (potassium-sparing) and furosemide (loop diuretic) to reduce fluid accumulation. Albumin infusions post-paracentesis to prevent complications like hypovolemia.

Prevalence: How common the health condition is within a specific population.
Approximately 50% of patients with cirrhosis develop ascites within 10 years of diagnosis.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Chronic liver disease, excessive alcohol use, hepatitis infection, malignancies (e.g., ovarian cancer), and heart or kidney failure.

Prognosis: The expected outcome or course of the condition over time.
Dependent on the cause; ascites related to cirrhosis indicates advanced liver disease and carries a 50% mortality rate over two years without transplant.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Spontaneous bacterial peritonitis, hepatorenal syndrome, and impaired quality of life due to recurrent fluid accumulation.

Functional Dyspepsia

Specialty: Gastrointestinal

Category: General and Miscellaneous GI Conditions

Sub-category: Abdominal Pain and Disorders

Symptoms:
upper abdominal pain or discomfort; bloating; nausea; early satiety; belching

Root Cause:
Functional dyspepsia is a functional gastrointestinal disorder with no detectable structural abnormalities, often linked to hypersensitivity of the stomach lining, delayed gastric emptying, or altered gut-brain interaction.

How it's Diagnosed: videos
Diagnosis is typically clinical, based on Rome IV criteria, and involves ruling out structural causes with endoscopy, imaging, or lab tests to exclude Helicobacter pylori infection or other conditions.

Treatment:
Lifestyle modifications (e.g., smaller meals, avoiding triggers like caffeine and fatty foods), stress management, and medications.

Medications:
Proton pump inhibitors (e.g., omeprazole ), H2 receptor antagonists (e.g., ranitidine), prokinetics (e.g., metoclopramide ), or low-dose tricyclic antidepressants (e.g., amitriptyline ) to manage symptoms.

Prevalence: How common the health condition is within a specific population.
Affects approximately 10-20% of the global population, with higher rates in women and younger adults.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Psychological stress, anxiety, depression, Helicobacter pylori infection, and dietary triggers.

Prognosis: The expected outcome or course of the condition over time.
Symptoms can be managed with treatment, but some patients may experience chronic symptoms or episodic recurrences.

Complications: Additional problems or conditions that may arise as a result of the original condition.
While not life-threatening, untreated symptoms can significantly reduce quality of life and lead to anxiety or depression.

Angle-Closure Glaucoma

Specialty: Ophthalmology

Category: Glaucoma

Symptoms:
severe eye pain; headaches; nausea; blurry vision; halos around lights; red eyes

Root Cause:
Sudden blockage of drainage canals raises eye pressure and damages the optic nerve.

How it's Diagnosed: videos
Gonioscopy and IOP measurement.

Treatment:
Medications like Latanoprost or Timolol, laser trabeculoplasty, or surgery.

Medications:
Hyperosmotic agents (e.g., Mannitol ), acetazolamide , and surgical or laser procedures (e.g., iridotomy).

Prevalence: How common the health condition is within a specific population.
Less common than open-angle glaucoma; more prevalent in Asian populations.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Hyperopia, advanced age, female gender, family history.

Prognosis: The expected outcome or course of the condition over time.
Requires immediate treatment to prevent permanent vision loss.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Sudden and severe vision loss, optic nerve damage.

Neuromyelitis Optica Spectrum Disorder (NMOSD)

Specialty: Neurology

Category: Demyelinating and Autoimmune Disorders

Symptoms:
severe optic neuritis; paralysis or weakness; loss of bladder/bowel control; nausea; vomiting; hiccups

Root Cause:
Autoimmune attack on aquaporin-4 water channels in astrocytes of the CNS, leading to inflammation and demyelination.

How it's Diagnosed: videos
Detection of aquaporin-4 antibodies (AQP4-IgG), MRI showing spinal cord or optic nerve lesions, and clinical symptom history.

Treatment:
Immunosuppressive therapies, plasmapheresis for acute attacks, and preventative treatments to reduce relapses.

Medications:
Rituximab (monoclonal antibody targeting CD20), corticosteroids (e.g., methylprednisolone ), azathioprine , and mycophenolate mofetil (immunosuppressants).

Prevalence: How common the health condition is within a specific population.
Rare, affecting approximately 1-10 per 100,000 people, more common in women and certain ethnic groups.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Female gender, autoimmune conditions, genetic predisposition, and certain infections.

Prognosis: The expected outcome or course of the condition over time.
Relapsing disease with potential for severe disability if untreated; early treatment improves outcomes.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Permanent vision loss, spinal cord damage, and secondary infections.

Acute Disseminated Encephalomyelitis (ADEM)

Specialty: Infectious Diseases

Category: CNS Infections

Symptoms:
fever; headache; nausea; vomiting; confusion; seizures; motor weakness; vision problems; lethargy

Root Cause:
An autoimmune response often triggered by an infection or, less commonly, vaccination, causing inflammation and demyelination in the brain and spinal cord.

How it's Diagnosed: videos
Clinical evaluation, MRI of the brain (showing diffuse demyelination), lumbar puncture (to analyze cerebrospinal fluid), and exclusion of other conditions like multiple sclerosis.

Treatment:
High-dose corticosteroids (e.g., methylprednisolone), plasma exchange (plasmapheresis), intravenous immunoglobulin (IVIG), and supportive care.

Medications:
Corticosteroids (e.g., methylprednisolone for reducing inflammation), IVIG (immunomodulatory therapy), or plasmapheresis (used when steroids are insufficient). Corticosteroids are classified as anti-inflammatory agents.

Prevalence: How common the health condition is within a specific population.
Rare; estimated annual incidence is 0.4-0.8 per 100,000 people, more common in children than adults.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Recent viral or bacterial infections, recent vaccination, genetic predisposition, or underlying autoimmune disorders.

Prognosis: The expected outcome or course of the condition over time.
Good in most cases; symptoms often resolve with treatment, although some individuals may experience residual neurological deficits.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Long-term neurological impairment, recurrence (though rare), or progression to conditions like multiple sclerosis in some cases.

Migraine

Specialty: Neurology

Category: Headaches and Pain Syndromes

Symptoms:
severe, throbbing headache; nausea; vomiting; sensitivity to light (photophobia); sensitivity to sound (phonophobia); visual disturbances (auras in some cases)

Root Cause:
Abnormal brain activity affecting nerve signaling, blood flow, and brain chemicals.

How it's Diagnosed: videos
Clinical evaluation based on patient history and symptoms, fulfilling International Classification of Headache Disorders (ICHD) criteria; imaging is used to rule out other conditions.

Treatment:
Lifestyle modifications, migraine prophylaxis, acute migraine treatments.

Medications:
Acute treatments include triptans (e.g., sumatriptan , rizatriptan , serotonin receptor agonists), NSAIDs (e.g., ibuprofen , naproxen ), and antiemetics (e.g., metoclopramide ). Preventive treatments include beta-blockers (e.g., propranolol ), calcium channel blockers (e.g., verapamil ), anticonvulsants (e.g., topiramate , valproate), and CGRP inhibitors (e.g., erenumab ).

Prevalence: How common the health condition is within a specific population.
Affects approximately 15% of the global population, with higher prevalence in females.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Family history, hormonal changes (e.g., menstruation), stress, certain foods, dehydration, lack of sleep, sensory triggers.

Prognosis: The expected outcome or course of the condition over time.
Chronic condition with varying frequency and severity; managed effectively in most cases with treatment.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Increased risk of stroke, medication overuse headache, depression, and anxiety.

Migraine Without Aura

Specialty: Neurology

Category: Headaches and Pain Syndromes

Symptoms:
pulsating or throbbing headache; nausea; vomiting; sensitivity to light and sound; pain aggravated by physical activity

Root Cause:
Dysfunction in brainstem and interactions with the trigeminal nerve, leading to abnormal pain processing and inflammation.

How it's Diagnosed: videos
Based on ICHD criteria; recurrent headaches lasting 4-72 hours with at least two pain characteristics and associated symptoms.

Treatment:
Acute treatments focus on symptom relief, and preventive measures aim to reduce frequency and severity.

Medications:
Acute medications include triptans, NSAIDs, acetaminophen , and antiemetics; prophylactic medications include beta-blockers (e.g., propranolol ), anticonvulsants (e.g., topiramate ), and CGRP inhibitors (e.g., fremanezumab ).

Prevalence: How common the health condition is within a specific population.
More common than migraines with aura, affecting up to 10% of the global population.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Stress, hormonal changes, sleep disturbances, dehydration, and dietary triggers.

Prognosis: The expected outcome or course of the condition over time.
Typically chronic but manageable; treatment improves quality of life.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Medication overuse headache, anxiety, depression, and increased stroke risk in specific populations.

Post-Traumatic Headache

Specialty: Neurology

Category: Headaches and Pain Syndromes

Symptoms:
headache following a head injury; dizziness; nausea; sensitivity to light and sound; difficulty concentrating

Root Cause:
Result of trauma to the head or neck, leading to nerve irritation, vascular changes, or muscle strain.

How it's Diagnosed: videos
Headache onset within 7 days of trauma or regaining consciousness; imaging if symptoms suggest intracranial injury.

Treatment:
Symptomatic management, physical therapy, and psychological support.

Medications:
NSAIDs, triptans, or amitriptyline for chronic cases; muscle relaxants if tension is a factor.

Prevalence: How common the health condition is within a specific population.
Common after concussions or mild traumatic brain injuries, affecting up to 50% of cases.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Severity of initial injury, previous headache history, psychological stress.

Prognosis: The expected outcome or course of the condition over time.
Often resolves within weeks to months; some cases become chronic.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Cognitive difficulties, depression, or chronic pain syndromes.

Meningitis (Bacterial, Viral, Fungal)

Specialty: Neurology

Category: Infections and Inflammatory Diseases

Symptoms:
fever; headache; neck stiffness; nausea; vomiting; sensitivity to light (photophobia); altered mental status; seizures

Root Cause:
Inflammation of the meninges, typically caused by bacterial, viral, or fungal infections.

How it's Diagnosed: videos
Lumbar puncture to analyze cerebrospinal fluid (CSF); blood cultures; imaging (CT/MRI) for complications or suspected mass lesions; PCR for viral causes.

Treatment:
Treatment depends on the cause. Bacterial meningitis requires prompt antibiotic therapy, while viral meningitis may resolve on its own or require supportive care. Fungal meningitis is treated with antifungals.

Medications:
For bacterial meningitis - Empiric antibiotics such as ceftriaxone and vancomycin , with targeted therapy after pathogen identification. Corticosteroids (e.g., dexamethasone ) may reduce inflammation. For viral meningitis - Antiviral drugs like acyclovir for herpes simplex virus. For fungal meningitis - Amphotericin B and flucytosine for Cryptococcus species.

Prevalence: How common the health condition is within a specific population.
Varies globally; bacterial meningitis is more common in low-income regions, while viral meningitis is more frequent in developed countries.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Close contact with infected individuals, weakened immune system, head injury, neurosurgical procedures, certain geographic areas (e.g., meningitis belt in Sub-Saharan Africa).

Prognosis: The expected outcome or course of the condition over time.
Bacterial meningitis can be life-threatening if untreated but has good outcomes with prompt treatment. Viral meningitis usually resolves without long-term effects. Fungal meningitis has a more guarded prognosis, especially in immunocompromised patients.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Brain damage, hearing loss, seizures, hydrocephalus, septic shock, death (especially in untreated bacterial cases).

Brain Abscess

Specialty: Infectious Diseases

Category: CNS Infections

Symptoms:
headache; fever; nausea; vomiting; neurological deficits; seizures; altered mental status

Root Cause:
Focal collection of pus in the brain tissue, often caused by bacterial or fungal infections entering through the bloodstream, contiguous spread, or trauma.

How it's Diagnosed: videos
MRI or CT scan with contrast, blood cultures, and biopsy of the abscess for microbiological testing.

Treatment:
Surgical drainage or aspiration, combined with broad-spectrum antibiotics tailored based on culture results.

Medications:
Antibiotics such as ceftriaxone (a cephalosporin) or metronidazole (an anti-anaerobic agent). For fungal infections, amphotericin B or fluconazole may be used.

Prevalence: How common the health condition is within a specific population.
Rare, with an estimated incidence of 0.3 to 1.3 cases per 100,000 people annually.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Immunocompromised status (HIV, organ transplantation), chronic sinusitis, otitis media, congenital heart defects, head trauma.

Prognosis: The expected outcome or course of the condition over time.
With prompt treatment, mortality rates are around 10–20%, but neurological deficits may persist.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Increased intracranial pressure, brain herniation, seizures, recurrence of infection, or neurological impairments.

Neurocysticercosis

Specialty: Infectious Diseases

Category: CNS Infections

Sub-category: Parasitic Infections

Symptoms:
seizures; headache; nausea; vomiting; vision problems; hydrocephalus; altered mental status

Root Cause:
Infection of the central nervous system by Taenia solium larvae (pork tapeworm), leading to cyst formation in the brain.

How it's Diagnosed: videos
Neuroimaging (MRI or CT) revealing cysts or calcifications, serologic tests for T. solium antibodies, and CSF analysis.

Treatment:
Antiparasitic therapy with albendazole or praziquantel, corticosteroids to reduce inflammation, anticonvulsants for seizure management, and surgical intervention in severe cases.

Medications:
Albendazole (antiparasitic), praziquantel (antiparasitic), dexamethasone (corticosteroid), and levetiracetam or phenytoin (anticonvulsants).

Prevalence: How common the health condition is within a specific population.
Leading cause of acquired epilepsy in developing countries; affects millions globally, particularly in regions with poor sanitation.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Consumption of undercooked pork, poor sanitation, close contact with infected individuals, and living in endemic areas.

Prognosis: The expected outcome or course of the condition over time.
Favorable with treatment in uncomplicated cases; long-term anticonvulsant therapy may be required for seizure control.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Chronic epilepsy, hydrocephalus, intracranial hypertension, and neurological deficits.

Glioblastoma Multiforme (GBM)

Specialty: Oncology

Category: Solid Tumors

Sub-category: Central Nervous System (CNS) Tumors

Symptoms:
headaches; nausea; vomiting; seizures; neurological deficits (e.g., weakness, vision changes); cognitive or personality changes; speech difficulties

Root Cause:
Uncontrolled proliferation of astrocytes, leading to a highly aggressive and infiltrative malignant tumor in the brain.

How it's Diagnosed: videos
Magnetic Resonance Imaging (MRI) with contrast, biopsy for histopathological confirmation, molecular testing (e.g., MGMT promoter methylation, IDH mutation status).

Treatment:
Surgery for tumor resection, followed by radiotherapy and temozolomide chemotherapy. Experimental treatments include targeted therapies, tumor-treating fields (TTFields), and immunotherapy.

Medications:
Temozolomide (alkylating agent), bevacizumab (anti-VEGF monoclonal antibody), corticosteroids like dexamethasone (to reduce cerebral edema).

Prevalence: How common the health condition is within a specific population.
Accounts for approximately 15% of all primary brain tumors; incidence is 3.19 cases per 100,000 individuals annually.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Advanced age, male gender, exposure to ionizing radiation, history of certain genetic disorders (e.g., Li-Fraumeni syndrome, Turcot syndrome).

Prognosis: The expected outcome or course of the condition over time.
Poor prognosis; median survival is 15-18 months with standard therapy, and 5-year survival rates are below 10%.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Cerebral edema, increased intracranial pressure, neurological deficits, cognitive decline, seizures, recurrence of tumor.

Ependymomas

Specialty: Oncology

Category: Solid Tumors

Sub-category: Central Nervous System (CNS) Tumors

Symptoms:
headaches; nausea; vomiting; hydrocephalus-related symptoms (e.g., balance issues, gait problems); visual disturbances; back pain (if spinal cord involvement)

Root Cause:
Tumors arising from ependymal cells lining the ventricles of the brain and the central canal of the spinal cord.

How it's Diagnosed: videos
MRI with contrast, biopsy for histological confirmation, cerebrospinal fluid (CSF) analysis for metastatic disease.

Treatment:
Surgical resection, followed by radiotherapy; chemotherapy in select cases (especially in pediatric patients).

Medications:
Corticosteroids (e.g., dexamethasone ) for symptom management, chemotherapy agents like cisplatin and vincristine in some pediatric cases.

Prevalence: How common the health condition is within a specific population.
Rare, accounting for 2-3% of all primary brain tumors; more common in children than adults.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Genetic syndromes (e.g., Neurofibromatosis Type 2), exposure to ionizing radiation.

Prognosis: The expected outcome or course of the condition over time.
Prognosis varies by grade and resectability; 5-year survival rates for Grade II are 50-70%, while higher-grade tumors have poorer outcomes.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Hydrocephalus, neurological deficits, tumor recurrence, metastatic spread in the CNS.

Concussion

Specialty: Neurology

Category: Traumatic Brain and Spinal Cord Injuries

Symptoms:
headache; confusion; dizziness; nausea; vomiting; blurred vision; sensitivity to light and noise; memory loss; difficulty concentrating; fatigue

Root Cause:
A mild traumatic brain injury caused by a sudden impact or jolt to the head, leading to temporary disruption of brain function.

How it's Diagnosed: videos
Clinical evaluation (patient history, symptom analysis, and physical examination), neurocognitive testing, imaging tests like CT or MRI (if severe symptoms or risk of complications).

Treatment:
Rest, gradual return to activities, symptom management, cognitive and physical rehabilitation if needed.

Medications:
Pain relievers like acetaminophen or ibuprofen for headaches. Prescription medications, such as amitriptyline (tricyclic antidepressant) or topiramate (antiepileptic), may be used for post-concussion headaches or migraines.

Prevalence: How common the health condition is within a specific population.
Common; estimated 1.6–3.8 million concussions occur annually in the U.S. related to sports and recreational activities.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Participation in contact sports, history of previous concussions, motor vehicle accidents, falls, younger age (children and adolescents).

Prognosis: The expected outcome or course of the condition over time.
Generally good, with most people recovering fully within weeks to months; symptoms may persist longer in post-concussion syndrome.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Post-concussion syndrome, second impact syndrome, chronic traumatic encephalopathy (CTE), persistent cognitive or emotional problems.

Postural Orthostatic Tachycardia Syndrome (POTS)

Specialty: Neurology

Category: Autonomic Nervous System Disorders

Symptoms:
rapid heartbeat upon standing; dizziness; lightheadedness; fainting; fatigue; brain fog; nausea; cold extremities; chest pain; exercise intolerance

Root Cause:
Dysregulation of the autonomic nervous system, leading to abnormal heart rate and blood flow response to positional changes.

How it's Diagnosed: videos
Tilt table test, standing test (measuring heart rate and blood pressure changes), patient history, and ruling out other causes of symptoms.

Treatment:
Non-pharmacological interventions such as increasing salt and fluid intake, wearing compression garments, physical therapy, and lifestyle modifications; pharmacological treatments based on symptoms and patient response.

Medications:
Medications include beta-blockers (e.g., propranolol ) to reduce heart rate, fludrocortisone (a mineralocorticoid) to increase blood volume, midodrine (an alpha-1 agonist) to raise blood pressure, and ivabradine (a heart rate-reducing agent).

Prevalence: How common the health condition is within a specific population.
Affects approximately 0.2% of the population; more common in women, particularly between the ages of 15 and 50.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Female sex, family history of dysautonomia, history of viral illness, autoimmune diseases, and conditions like Ehlers-Danlos Syndrome or chronic fatigue syndrome.

Prognosis: The expected outcome or course of the condition over time.
Often manageable with treatment, though symptoms may persist for years; improvement is possible with lifestyle changes and targeted therapies.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Severe limitations in daily activities, increased risk of falls, anxiety or depression due to chronic illness, and possible progression to other forms of dysautonomia.

Peptic ulcer disease

Specialty: Senior Health and Geriatrics

Category: Chronic Diseases and Multimorbidity

Sub-category: Gastrointestinal and Hepatic Disorders

Symptoms:
abdominal pain; bloating; nausea; vomiting; heartburn; loss of appetite; weight loss

Root Cause:
Ulcers in the stomach lining or the first part of the small intestine caused by an imbalance between stomach acid and protective factors.

How it's Diagnosed: videos
Based on symptoms, endoscopy, and tests for H. pylori infection (blood, breath, or stool tests).

Treatment:
Proton pump inhibitors (PPIs), antibiotics for H. pylori infection, antacids, and sometimes surgery.

Medications:
Proton pump inhibitors (e.g., lansoprazole ), H2 blockers (e.g., ranitidine), antibiotics (e.g., clarithromycin , amoxicillin for H. pylori), and antacids.

Prevalence: How common the health condition is within a specific population.
Affects 10-15% of people at some point in their lives, more common in those aged 55-70.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
H. pylori infection, long-term NSAID use, alcohol use, smoking, stress, and spicy foods.

Prognosis: The expected outcome or course of the condition over time.
With appropriate treatment, most ulcers heal within a few weeks; recurrence is common if risk factors are not managed.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Gastrointestinal bleeding, perforation, gastric cancer.

Diverticulosis/Diverticulitis

Specialty: Senior Health and Geriatrics

Category: Chronic Diseases and Multimorbidity

Sub-category: Gastrointestinal and Hepatic Disorders

Symptoms:
abdominal pain; fever; nausea; change in bowel habits; constipation or diarrhea; bloating; rectal bleeding

Root Cause:
Diverticulosis is the formation of small pouches in the colon; diverticulitis occurs when these pouches become inflamed or infected.

How it's Diagnosed: videos
Colonoscopy, CT scan, or abdominal ultrasound.

Treatment:
Antibiotics for infection, dietary modifications (high-fiber diet), and pain relief; in severe cases, surgery.

Medications:
Antibiotics (e.g., ciprofloxacin , metronidazole ), pain relievers (e.g., acetaminophen ), and antispasmodics (e.g., dicyclomine ).

Prevalence: How common the health condition is within a specific population.
Affects 50-60% of individuals aged 60 and older in Western populations.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Age, low-fiber diet, obesity, physical inactivity, and smoking.

Prognosis: The expected outcome or course of the condition over time.
Generally manageable with lifestyle changes, but recurrent episodes of diverticulitis may require surgical intervention.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Abscesses, perforation, peritonitis, fistulas, and bleeding.

Hepatitis (Chronic, e.g., Hepatitis C)

Specialty: Senior Health and Geriatrics

Category: Chronic Diseases and Multimorbidity

Sub-category: Gastrointestinal and Hepatic Disorders

Symptoms:
fatigue; jaundice; abdominal pain; dark urine; loss of appetite; nausea; itchy skin

Root Cause:
Chronic inflammation of the liver caused by the hepatitis C virus (HCV), leading to potential liver damage over time.

How it's Diagnosed: videos
Blood tests to detect HCV antibodies and RNA, liver function tests, and liver biopsy or elastography for assessing liver damage.

Treatment:
Antiviral medications such as direct-acting antivirals (DAAs), and lifestyle changes to manage symptoms.

Medications:
Direct-acting antivirals (DAAs) such as sofosbuvir , ledipasvir , glecaprevir /pibrentasvir , ribavirin in some cases.

Prevalence: How common the health condition is within a specific population.
Hepatitis C affects approximately 1-2% of the global population, with higher prevalence among older adults and those with a history of intravenous drug use.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
History of intravenous drug use, blood transfusions prior to 1992, needle sharing, unprotected sex, and tattoos or piercings in unsanitary conditions.

Prognosis: The expected outcome or course of the condition over time.
With appropriate antiviral therapy, the infection can be cured, but chronic infection can lead to cirrhosis, liver failure, or liver cancer if untreated.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Cirrhosis, liver failure, liver cancer (hepatocellular carcinoma), and portal hypertension.

Chronic Kidney Disease (CKD)

Specialty: Nephrology

Category: Chronic and Acute Kidney Diseases

Symptoms:
fatigue; swelling in ankles, feet, or hands; frequent urination, especially at night; nausea; loss of appetite; muscle cramps; itchy skin; shortness of breath

Root Cause:
Gradual loss of kidney function over time due to diabetes, hypertension, or other chronic conditions leading to decreased filtration capacity.

How it's Diagnosed: videos
Blood tests (e.g., creatinine and eGFR), urine tests (e.g., protein or albumin levels), imaging studies (e.g., ultrasound), and kidney biopsy in select cases.

Treatment:
Managing underlying conditions (e.g., diabetes, hypertension), lifestyle changes, dietary modifications, and slowing progression with medications like ACE inhibitors or ARBs.

Medications:
Medications may include ACE inhibitors (e.g., lisinopril ), angiotensin receptor blockers (e.g., losartan ), diuretics, phosphate binders, and erythropoiesis-stimulating agents for anemia.

Prevalence: How common the health condition is within a specific population.
Affects approximately 10% of the global population, with higher prevalence in individuals over 60.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Diabetes, hypertension, cardiovascular disease, obesity, family history of kidney disease, and advanced age.

Prognosis: The expected outcome or course of the condition over time.
Variable; early detection and treatment can slow progression, but advanced CKD may progress to end-stage renal disease requiring dialysis or transplantation.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Anemia, electrolyte imbalances, cardiovascular disease, bone disorders, fluid overload, and progression to end-stage renal disease (ESRD).

Recurrent Clostridium difficile infection

Specialty: Senior Health and Geriatrics

Category: Infectious Diseases

Sub-category: Chronic and Recurrent Infections

Symptoms:
severe diarrhea (watery stools); abdominal cramps; fever; loss of appetite; nausea; dehydration; in some cases, colonic perforation or toxic megacolon

Root Cause:
Overgrowth of Clostridium difficile bacteria in the colon after disruption of normal gut flora, typically caused by antibiotic use. The bacteria produce toxins that cause inflammation and damage to the intestinal lining.

How it's Diagnosed: videos
Diagnosis is confirmed by stool tests to detect Clostridium difficile toxins (PCR or enzyme immunoassay) or culture. Colonoscopy or imaging may be used in severe cases to assess colonic damage.

Treatment:
First-line treatment involves oral antibiotics such as vancomycin or fidaxomicin. For recurrent cases, fecal microbiota transplantation (FMT) is an option. Discontinuation of the inciting antibiotics and infection control measures are important.

Medications:
The main medications for treating C. difficile infection include oral vancomycin (a glycopeptide antibiotic), fidaxomicin (a macrolide antibiotic), and metronidazole (used for mild cases). In recurrent infections, fecal microbiota transplantation (FMT) is also used as a treatment.

Prevalence: How common the health condition is within a specific population.
The incidence of C. difficile infection is higher in healthcare settings, particularly among older adults and those with weakened immune systems. It is one of the leading causes of healthcare-associated infections in the U.S.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Advanced age, prolonged use of antibiotics (especially broad-spectrum antibiotics), weakened immune system (due to cancer treatments, organ transplants, or chronic diseases), previous C. difficile infection.

Prognosis: The expected outcome or course of the condition over time.
While most cases resolve with antibiotics, recurrent infections are common, particularly in older adults. Early diagnosis and treatment are crucial for a better prognosis.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Severe dehydration, colonic perforation, toxic megacolon, and sepsis in extreme cases. Recurrence is common, and patients may experience multiple episodes over time.

Palliative and End-of-Life Care

Specialty: Senior Health and Geriatrics

Category: Geriatric Syndromes

Symptoms:
pain; shortness of breath; fatigue; nausea; loss of appetite; difficulty sleeping; anxiety; depression; emotional distress

Root Cause:
Progressive, incurable illnesses such as cancer, advanced heart disease, or neurodegenerative conditions. Aimed at alleviating symptoms and improving quality of life rather than curing the underlying disease.

How it's Diagnosed: videos
Palliative care specialists assess symptoms, goals of care, and prognosis. This process often involves input from oncologists, cardiologists, or neurologists.

Treatment:
Symptom management through medications (analgesics, antiemetics, etc.), psychological support, spiritual care, and counseling. Hospice care is often used in the final stages of life.

Medications:
Opioids (morphine or fentanyl ) for pain management, antiemetics like ondansetron for nausea, anxiolytics such as lorazepam for anxiety, and corticosteroids for appetite stimulation.

Prevalence: How common the health condition is within a specific population.
Common in those with advanced age, particularly among those with terminal illnesses.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Advanced age, terminal illness, declining functional status, and frailty.

Prognosis: The expected outcome or course of the condition over time.
Focus is on comfort rather than cure; the prognosis depends on the underlying condition and the effectiveness of symptom management.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Complications often include unmanaged symptoms, family distress, and caregiver burnout. If palliative care is not available, unnecessary suffering may occur.

Egg Allergy

Specialty: Allergies and Immunology

Category: Allergic Disorders

Sub-category: Food Allergies

Symptoms:
skin reactions like hives or eczema; stomach pain; nausea; nasal congestion; anaphylaxis in severe cases

Root Cause:
Immune system reaction to proteins in egg whites or yolks, most commonly ovalbumin.

How it's Diagnosed: videos
Skin prick tests, specific IgE blood tests, oral food challenge.

Treatment:
Avoidance of eggs and egg-based products, epinephrine for severe reactions, oral immunotherapy in some cases.

Medications:
Epinephrine auto-injectors (e.g., EpiPen, Auvi-Q) for anaphylaxis and oral antihistamines (e.g., Diphenhydramine , Loratadine ) for mild reactions.

Prevalence: How common the health condition is within a specific population.
Affects approximately 0.5-5% of children; many outgrow it by age 5-

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Family history of allergies, atopic conditions, early introduction of eggs in diet.

Prognosis: The expected outcome or course of the condition over time.
Favorable for most children; lifelong management needed for persistent cases.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Anaphylaxis, dietary restrictions leading to potential nutrient deficiencies.

Fish Allergy

Specialty: Allergies and Immunology

Category: Allergic Disorders

Sub-category: Food Allergies

Symptoms:
hives; swelling; stomach pain; nausea; difficulty breathing; anaphylaxis

Root Cause:
Immune system reaction to fish proteins, such as parvalbumin.

How it's Diagnosed: videos
Skin prick testing, specific IgE blood tests, oral food challenge.

Treatment:
Avoidance of fish, use of epinephrine for severe reactions, education on avoiding cross-contamination.

Medications:
Epinephrine auto-injectors (e.g., EpiPen, Auvi-Q) and oral antihistamines (e.g., Diphenhydramine , Cetirizine ).

Prevalence: How common the health condition is within a specific population.
Affects approximately 1% of the global population; more common in adults than children.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Family history of allergies, prior reactions to fish, geographic dietary practices.

Prognosis: The expected outcome or course of the condition over time.
Rarely outgrown; lifelong avoidance is typically required.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Anaphylaxis, cross-reactivity with other types of fish, limited dietary options in certain regions.

Wheat Allergy

Specialty: Allergies and Immunology

Category: Allergic Disorders

Sub-category: Food Allergies

Symptoms:
hives; swelling; nausea; vomiting; difficulty breathing; anaphylaxis

Root Cause:
Immune system reaction to proteins found in wheat, including gluten and albumin.

How it's Diagnosed: videos
Skin prick tests, specific IgE blood tests, oral food challenge.

Treatment:
Avoidance of wheat products, substitution with gluten-free grains, use of epinephrine for severe reactions.

Medications:
Epinephrine auto-injectors (e.g., EpiPen, Auvi-Q) and oral antihistamines (e.g., Diphenhydramine , Loratadine ).

Prevalence: How common the health condition is within a specific population.
Affects approximately 0.2-1% of children and adults.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Family history of allergies, atopic conditions, prior allergic reactions to wheat.

Prognosis: The expected outcome or course of the condition over time.
Many children outgrow it by age 12; adults may need lifelong management.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Anaphylaxis, misdiagnosis with celiac disease or gluten sensitivity, limited dietary options.

Eosinophilic Gastroenteritis

Specialty: Allergies and Immunology

Category: Other Related Disorders

Sub-category: Eosinophilic Disorders

Symptoms:
abdominal pain; nausea; diarrhea; vomiting; weight loss; fatigue; anemia

Root Cause:
Eosinophilic infiltration of the gastrointestinal tract, likely triggered by food or environmental allergens.

How it's Diagnosed: videos
Endoscopy with biopsy showing eosinophilic infiltration, imaging studies, and blood tests for eosinophilia.

Treatment:
Elimination diets, corticosteroids, and symptom management (e.g., anti-nausea medications).

Medications:
Corticosteroids (e.g., Prednisone ) and dietary modifications.

Prevalence: How common the health condition is within a specific population.
Rare; precise prevalence is unknown.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Allergic diseases, family history of eosinophilic disorders, and certain infections.

Prognosis: The expected outcome or course of the condition over time.
Chronic but manageable with treatment; symptoms may relapse without ongoing management.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Bowel obstruction, malabsorption, and perforation in severe cases.

Hereditary Angioedema (HAE)

Specialty: Allergies and Immunology

Category: Other Related Disorders

Symptoms:
swelling of the skin and mucosal tissues; abdominal pain; nausea; vomiting; difficulty breathing; laryngeal swelling that may lead to airway obstruction

Root Cause:
Genetic mutation leading to a deficiency or dysfunction of C1 esterase inhibitor (C1-INH), causing uncontrolled activation of the complement system and increased bradykinin production.

How it's Diagnosed: videos
Blood tests measuring C1-INH levels and function, complement component C4 levels, and genetic testing for mutations in the SERPING1 gene.

Treatment:
C1-INH replacement therapy, bradykinin receptor antagonists (e.g., icatibant), kallikrein inhibitors (e.g., lanadelumab), and prophylactic medications for preventing attacks.

Medications:
C1 esterase inhibitor replacement therapy, bradykinin receptor antagonists (e.g., Icatibant ), and androgens (e.g., Danazol ).

Prevalence: How common the health condition is within a specific population.
Estimated at 1 in 50,000 to 1 in 100,000 individuals worldwide.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Family history of HAE (autosomal dominant inheritance), stress, trauma, infections, hormonal changes, certain medications (e.g., ACE inhibitors).

Prognosis: The expected outcome or course of the condition over time.
With proper management, most patients can lead normal lives; untreated cases may result in life-threatening airway obstruction.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Potentially fatal laryngeal edema, psychological distress due to unpredictable swelling episodes, reduced quality of life, and delays in diagnosis.

Penetrating brain injury (e.g., gunshot wounds)

Specialty: Trauma and Injuries

Category: Head and Neck Injuries

Sub-category: Head Injuries

Symptoms:
loss of consciousness; severe headache; nausea; vomiting; neurological deficits; seizures; cognitive impairment; hemorrhage

Root Cause:
Direct injury caused by a foreign object (e.g., bullet) penetrating the skull and brain tissue, causing localized damage and potential hemorrhage.

How it's Diagnosed: videos
Diagnosis is confirmed via CT scans or MRI, and clinical assessment for neurological deficits.

Treatment:
Immediate surgical intervention may be required to remove the foreign object and control bleeding, followed by intensive care, brain stabilization, and rehabilitation. Antibacterial treatment may be administered to prevent infections.

Medications:
Antibiotics (e.g., ceftriaxone , vancomycin ) to prevent infections, analgesics (e.g., morphine for pain), and anticonvulsants (e.g., phenytoin ) for seizure prevention. These medications include antibiotics, analgesics, and anticonvulsants.

Prevalence: How common the health condition is within a specific population.
Penetrating brain injuries, such as those caused by gunshot wounds, are less common than blunt trauma but are frequently seen in violence-prone regions, accounting for around 10% of traumatic brain injuries.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Gunshot wounds, violent crime, war zones, and industrial accidents are significant risk factors.

Prognosis: The expected outcome or course of the condition over time.
Prognosis depends on the severity of the injury, the area of the brain affected, and the speed of medical intervention. Recovery may vary from complete recovery to permanent disability or death.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Infection (e.g., meningitis), hemorrhagic shock, cognitive deficits, paralysis, persistent seizures, and post-traumatic stress disorder (PTSD).

Liver laceration

Specialty: Trauma and Injuries

Category: Blunt Abdominal Trauma

Sub-category: Solid Organ Injuries

Symptoms:
right upper quadrant pain; abdominal tenderness; signs of internal bleeding (e.g., hypotension, tachycardia); nausea; vomiting; ecchymosis over the abdomen

Root Cause:
Traumatic damage to the liver caused by blunt force trauma, often resulting in bleeding and disruption of hepatic tissue.

How it's Diagnosed: videos
Clinical examination, focused assessment with sonography for trauma (FAST), contrast-enhanced CT scan, and laboratory tests (e.g., hemoglobin levels, liver enzymes).

Treatment:
Management depends on severity. Minor lacerations may be managed conservatively with observation and fluid resuscitation. Severe cases may require surgical intervention (e.g., laparotomy, hemostasis, or liver packing).

Medications:
Pain relief medications such as acetaminophen or opioids for severe pain. In cases of infection risk, prophylactic antibiotics like ceftriaxone (cephalosporin class) may be used.

Prevalence: How common the health condition is within a specific population.
Common in patients with blunt abdominal trauma; occurs in approximately 15-20% of such cases.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Motor vehicle collisions, falls from significant heights, sports injuries, or assaults involving blunt force to the abdomen.

Prognosis: The expected outcome or course of the condition over time.
Favorable in minor cases with proper treatment; severe lacerations carry a higher risk of mortality due to hemorrhage or associated injuries.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Hemorrhagic shock, bile leakage, peritonitis, abscess formation, sepsis.

Splenic rupture

Specialty: Trauma and Injuries

Category: Blunt Abdominal Trauma

Sub-category: Solid Organ Injuries

Symptoms:
left upper quadrant pain; kehr's sign (referred pain to the left shoulder); abdominal distension; hypotension; tachycardia; nausea; vomiting

Root Cause:
Splenic parenchymal and capsule disruption due to blunt trauma, leading to internal bleeding and potential hemodynamic instability.

How it's Diagnosed: videos
Physical examination, FAST scan, contrast-enhanced CT scan of the abdomen, and monitoring of hemoglobin levels.

Treatment:
Non-operative management with close monitoring and bed rest in stable cases. Unstable cases may require splenectomy or splenic repair surgery.

Medications:
Pain management with acetaminophen or NSAIDs. Post-splenectomy patients may require prophylactic vaccines against encapsulated bacteria (e.g., pneumococcal, meningococcal, and Haemophilus influenzae).

Prevalence: How common the health condition is within a specific population.
Occurs in approximately 25-30% of blunt abdominal trauma cases, making it the most commonly injured organ.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Blunt abdominal trauma from vehicle collisions, falls, or contact sports.

Prognosis: The expected outcome or course of the condition over time.
Good in stable cases with non-operative management; splenectomy patients have an increased lifelong risk of infections (overwhelming post-splenectomy infection, OPSI).

Complications: Additional problems or conditions that may arise as a result of the original condition.
Hemorrhagic shock, infection, OPSI, abscess formation.

Pancreatic injury

Specialty: Trauma and Injuries

Category: Blunt Abdominal Trauma

Sub-category: Solid Organ Injuries

Symptoms:
epigastric pain; nausea; vomiting; signs of peritonitis (in severe cases); elevated serum amylase or lipase

Root Cause:
Disruption or contusion of the pancreas caused by blunt trauma, leading to leakage of pancreatic enzymes and tissue inflammation.

How it's Diagnosed: videos
Clinical examination, serum amylase and lipase levels, CT scan with contrast, and endoscopic retrograde cholangiopancreatography (ERCP) in select cases.

Treatment:
Mild cases managed with bowel rest, hydration, and monitoring. Severe injuries may require surgical drainage, debridement, or partial pancreatectomy.

Medications:
Pain management with opioids. Antibiotics like piperacillin-tazobactam (penicillin class) for associated infections or abscesses.

Prevalence: How common the health condition is within a specific population.
Rare, occurring in less than 5% of blunt abdominal trauma cases.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Blunt force trauma from vehicle collisions, bicycle handlebars, or direct abdominal impacts.

Prognosis: The expected outcome or course of the condition over time.
Variable; minor injuries have good outcomes, but severe injuries can result in significant morbidity.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Pancreatic fistula, abscess formation, pseudocyst, diabetes mellitus, sepsis.

Intestinal perforation

Specialty: Trauma and Injuries

Category: Blunt Abdominal Trauma

Sub-category: Hollow organ injuries

Symptoms:
severe abdominal pain; fever; nausea; vomiting; abdominal distension; tenderness; guarding; rebound tenderness

Root Cause:
A tear or hole in the wall of the intestines that leads to leakage of intestinal contents into the abdominal cavity, causing peritonitis and infection.

How it's Diagnosed: videos
Clinical examination, imaging studies like X-rays (showing free air under the diaphragm), CT scans, blood tests showing elevated white blood cells (leukocytosis), and exploratory surgery.

Treatment:
Emergency surgery (laparotomy or laparoscopy) to repair the perforation, clean the abdominal cavity, and address any infection.

Medications:
Broad-spectrum antibiotics, such as piperacillin-tazobactam or ceftriaxone with metronidazole , are prescribed to manage infections. These are classified as antibacterial agents. Pain relievers and IV fluids may also be administered.

Prevalence: How common the health condition is within a specific population.
Common in cases of trauma, infections, or gastrointestinal conditions like peptic ulcers or diverticulitis. Exact prevalence varies by the underlying cause.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Abdominal trauma, gastrointestinal conditions (e.g., Crohn’s disease, diverticulitis, or cancer), infections, foreign body ingestion, and certain medications like NSAIDs.

Prognosis: The expected outcome or course of the condition over time.
Favorable with prompt treatment but worsens with delays, leading to life-threatening sepsis.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Peritonitis, sepsis, abscess formation, multi-organ failure, and death if untreated.

Stomach rupture

Specialty: Trauma and Injuries

Category: Blunt Abdominal Trauma

Sub-category: Hollow organ injuries

Symptoms:
severe upper abdominal pain; abdominal swelling; nausea; vomiting; hematemesis (vomiting blood); hypotension; shock

Root Cause:
A breach in the stomach wall, often due to blunt trauma, increased gastric pressure, or penetrating injuries, leading to leakage of gastric contents into the abdominal cavity.

How it's Diagnosed: videos
Imaging (X-rays showing free air under the diaphragm), CT scan, upper GI endoscopy, and clinical symptoms indicative of peritonitis or shock.

Treatment:
Emergency surgical intervention to repair the rupture and clean the abdominal cavity. Postoperative care includes infection control and nutritional support.

Medications:
Broad-spectrum antibiotics, such as ceftriaxone or meropenem , combined with metronidazole to prevent infection. These are classified as antibacterial agents. Proton pump inhibitors (e.g., pantoprazole or omeprazole ) may be prescribed to reduce stomach acid and promote healing. Pain relief medications (e.g., opioids or acetaminophen ) are also used.

Prevalence: How common the health condition is within a specific population.
Rare but associated with significant blunt trauma (e.g., motor vehicle accidents) or extreme gastric distension (e.g., binge eating with vomiting).

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Blunt abdominal trauma, excessive gastric distension, gastric ulcers, ingestion of corrosive substances, or prior gastric surgeries.

Prognosis: The expected outcome or course of the condition over time.
With prompt surgical treatment, survival is high; delays increase risk of sepsis and death.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Peritonitis, sepsis, hemorrhage, abscess formation, and multi-organ failure.

Rhabdomyolysis (Muscle Breakdown)

Specialty: Trauma and Injuries

Category: Soft Tissue Injuries

Sub-category: Crush Injuries

Symptoms:
muscle pain; weakness; swelling; dark or tea-colored urine; fatigue; nausea; vomiting

Root Cause:
Breakdown of muscle tissue leads to the release of intracellular contents, including myoglobin, creatine kinase, and electrolytes, into the bloodstream, potentially causing kidney damage.

How it's Diagnosed: videos
Blood tests showing elevated creatine kinase (CK) levels, myoglobin in urine, electrolyte imbalances (hyperkalemia, hypocalcemia), and renal function tests.

Treatment:
Aggressive intravenous fluid resuscitation to prevent kidney damage, electrolyte correction, and, in severe cases, dialysis or fasciotomy.

Medications:
Medications for rhabdomyolysis may include sodium bicarbonate (to alkalinize urine), diuretics (to support urine output), and calcium gluconate (to manage hyperkalemia). These belong to classes such as alkalizing agents, diuretics, and electrolyte replacements.

Prevalence: How common the health condition is within a specific population.
Occurs in 26,000 cases per year in the U.S.; common causes include trauma, overexertion, and drug toxicity.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Trauma, crush injuries, prolonged immobility, intense exercise, dehydration, statin use, and drug or alcohol abuse.

Prognosis: The expected outcome or course of the condition over time.
Good with early treatment; delayed intervention may lead to acute kidney injury or death.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Acute kidney injury, electrolyte imbalances, compartment syndrome, cardiac arrhythmias, disseminated intravascular coagulation (DIC).

Tubulointerstitial Nephritis

Specialty: Nephrology

Category: Tubulointerstitial Diseases

Symptoms:
fatigue; nausea; loss of appetite; fever; rash; joint pain; decreased urine output; blood in urine; edema

Root Cause:
Inflammation of the kidney's tubules and interstitial tissue, often caused by an immune-mediated response to drugs, infections, or systemic diseases.

How it's Diagnosed: videos
Urinalysis (presence of white blood cells, red blood cells, or casts), blood tests (elevated creatinine and BUN), imaging (ultrasound or CT for structural abnormalities), kidney biopsy (to confirm inflammation and etiology).

Treatment:
Discontinuing causative agents, managing underlying infections or systemic diseases, corticosteroids or other immunosuppressants in severe cases.

Medications:
Corticosteroids (e.g., prednisone ) to reduce inflammation; antibiotics or antivirals for infection-related causes; immunosuppressive drugs (e.g., azathioprine or cyclosporine ) in autoimmune-associated cases.

Prevalence: How common the health condition is within a specific population.
Rare, accounting for approximately 10-15% of cases of acute kidney injury.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Use of nephrotoxic medications (e.g., NSAIDs, antibiotics like penicillin), infections (e.g., streptococcus, cytomegalovirus), autoimmune diseases (e.g., lupus, sarcoidosis).

Prognosis: The expected outcome or course of the condition over time.
Generally favorable with early detection and management; chronic kidney damage can occur if treatment is delayed or if the underlying cause persists.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Chronic kidney disease, permanent scarring of the kidneys, electrolyte imbalances, progression to end-stage renal disease.

Metabolic Acidosis

Specialty: Nephrology

Category: Acid-Base Disorders

Symptoms:
rapid breathing (kussmaul respirations); fatigue; confusion; headache; nausea; vomiting; low blood pressure in severe cases

Root Cause:
Accumulation of acid or loss of bicarbonate in the body due to kidney dysfunction, increased acid production, or bicarbonate loss.

How it's Diagnosed: videos
Blood gas analysis (low pH, low bicarbonate), anion gap calculation, and electrolyte tests.

Treatment:
Address the underlying cause (e.g., correcting lactic acidosis or ketoacidosis), bicarbonate therapy in severe cases, and supportive care.

Medications:
Sodium bicarbonate (buffer agent), dichloroacetate (used experimentally in certain types of metabolic acidosis).

Prevalence: How common the health condition is within a specific population.
Common in hospitalized patients, particularly those in critical care settings.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Chronic kidney disease, diabetes (ketoacidosis), sepsis, and diarrhea.

Prognosis: The expected outcome or course of the condition over time.
Dependent on the underlying cause; prompt treatment generally leads to a favorable outcome.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Cardiac arrhythmias, shock, and multiorgan failure if untreated.

Pyelonephritis (Acute and Chronic)

Specialty: Nephrology

Category: Infections and Infectious Conditions

Symptoms:
fever; chills; flank pain; nausea; vomiting; painful urination; frequent urination; cloudy or foul-smelling urine; fatigue

Root Cause:
Infection of the kidney, often caused by ascending bacterial infection from the bladder, typically due to E. coli or other uropathogens.

How it's Diagnosed: videos
Urinalysis (showing pyuria, bacteriuria, hematuria), urine culture, blood tests (e.g., elevated white blood cell count), imaging studies (e.g., ultrasound or CT scan if complications are suspected).

Treatment:
Antibiotics are the primary treatment. Severe cases may require hospitalization for intravenous antibiotics and supportive care. Chronic pyelonephritis may need surgical correction of underlying anatomical issues.

Medications:
Acute cases

Prevalence: How common the health condition is within a specific population.
Common in sexually active women, with higher rates in those with recurrent urinary tract infections. Chronic cases are rare and often associated with anatomical abnormalities or obstruction.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Female gender, pregnancy, recurrent UTIs, diabetes, urinary tract obstruction, vesicoureteral reflux, catheterization.

Prognosis: The expected outcome or course of the condition over time.
Excellent with timely treatment; chronic cases may lead to kidney scarring and impaired function.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Sepsis, renal abscesses, chronic kidney disease, hypertension.

Diabetes Mellitus (Diabetic Nephropathy)

Specialty: Nephrology

Category: Systemic Diseases with Renal Involvement

Symptoms:
proteinuria (protein in the urine); swelling (edema) in the legs and ankles; elevated blood pressure; fatigue; nausea; frequent urination; unexplained weight loss

Root Cause:
Chronic high blood sugar levels damage the glomeruli in the kidneys, impairing their ability to filter waste and leading to progressive kidney dysfunction.

How it's Diagnosed: videos
Urine tests to detect proteinuria, blood tests for serum creatinine and estimated glomerular filtration rate (eGFR), kidney biopsy in unclear cases.

Treatment:
Blood sugar control via lifestyle changes and medications, blood pressure management, dietary modifications (e.g., low-protein diet), and supportive care to prevent progression.

Medications:
Angiotensin-converting enzyme (ACE) inhibitors (e.g., lisinopril ) or angiotensin II receptor blockers (ARBs) (e.g., losartan ) to reduce proteinuria and protect kidney function; sodium-glucose co-transporter-2 (SGLT2) inhibitors (e.g., empagliflozin ) to improve glycemic control and delay kidney damage; insulin or oral hypoglycemics (e.g., metformin ) for blood sugar management; diuretics to manage fluid retention.

Prevalence: How common the health condition is within a specific population.
Affects approximately 20–40% of individuals with diabetes; more common in long-standing Type 1 and Type 2 diabetes.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Poor blood sugar control, long duration of diabetes, hypertension, obesity, family history of kidney disease, smoking.

Prognosis: The expected outcome or course of the condition over time.
Early-stage diabetic nephropathy can be slowed with proper management, but advanced stages may lead to end-stage renal disease (ESRD) requiring dialysis or transplantation.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Chronic kidney disease (CKD), end-stage renal disease (ESRD), cardiovascular disease, increased risk of infections.

Peritoneal Dialysis Infections

Specialty: Nephrology

Category: Dialysis and Transplant-Related Conditions

Sub-category: Dialysis-Associated Complications

Symptoms:
abdominal pain; cloudy peritoneal dialysis fluid; fever; nausea; redness or drainage at catheter site

Root Cause:
Bacterial or fungal infection of the peritoneal cavity, often caused by contamination during the exchange process or catheter-related issues.

How it's Diagnosed: videos
Analysis of peritoneal dialysis fluid for elevated white blood cell count and culture to identify the causative organism.

Treatment:
Antibiotics or antifungal agents administered intraperitoneally or intravenously, catheter removal if the infection is severe or recurrent, and temporary cessation of peritoneal dialysis.

Medications:
First-line treatments include intraperitoneal antibiotics such as vancomycin (for Gram-positive organisms) and ceftazidime (for Gram-negative organisms). Antifungal agents like fluconazole may be prescribed for fungal infections.

Prevalence: How common the health condition is within a specific population.
Occurs in approximately 20-25% of peritoneal dialysis patients annually.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Poor hygiene during exchanges, diabetes, older age, use of a contaminated catheter, or a history of prior infections.

Prognosis: The expected outcome or course of the condition over time.
Good with early and appropriate treatment; untreated or severe cases can lead to peritonitis and necessitate a switch to hemodialysis.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Adhesions, loss of peritoneal membrane function, sepsis, and eventual requirement for a new dialysis modality.

NSAIDs, Aminoglycosides, Cisplatin, etc.

Specialty: Nephrology

Category: Other Renal-Associated Conditions

Sub-category: Drug-Induced Nephrotoxicity

Symptoms:
decreased urine output; swelling (edema); fatigue; nausea; shortness of breath; elevated blood pressure

Root Cause:
These medications can cause direct injury to renal tubular cells, disrupt glomerular filtration, or induce interstitial inflammation. Mechanisms include oxidative stress, vasoconstriction, and impaired renal perfusion.

How it's Diagnosed: videos
Diagnosis involves patient history (exposure to nephrotoxic drugs), lab tests (elevated serum creatinine, blood urea nitrogen levels), urine analysis (proteinuria, hematuria), and imaging studies (ultrasound to assess kidney structure).

Treatment:
Discontinuation of the offending drug, supportive care, and measures to enhance renal recovery (hydration, electrolyte balance). In severe cases, dialysis may be required.

Medications:
Treatment includes medications like N-acetylcysteine (antioxidant used to mitigate cisplatin-induced toxicity), diuretics (loop diuretics like furosemide for volume control), and electrolyte supplements for disturbances. Medications to manage complications like antihypertensives may also be prescribed.

Prevalence: How common the health condition is within a specific population.
Drug-induced nephrotoxicity is reported in approximately 10-25% of hospitalized patients exposed to nephrotoxic agents.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Pre-existing renal impairment; Advanced age; Concurrent use of multiple nephrotoxic drugs; Dehydration; Diabetes; Hypertension

Prognosis: The expected outcome or course of the condition over time.
Prognosis varies depending on the extent of kidney damage and timely intervention. Acute kidney injury (AKI) caused by drugs is often reversible, but delayed treatment can lead to chronic kidney disease (CKD).

Complications: Additional problems or conditions that may arise as a result of the original condition.
Progression to chronic kidney disease; Electrolyte imbalances; Fluid overload; Increased risk of cardiovascular events; Need for long-term dialysis in severe cases

HELLP Syndrome

Specialty: Nephrology

Category: Other Renal-Associated Conditions

Sub-category: Pregnancy-Related Kidney Conditions

Symptoms:
right upper abdominal pain; nausea; vomiting; headache; swelling; high blood pressure; fatigue; visual disturbances

Root Cause:
Severe form of preeclampsia characterized by hemolysis (H), elevated liver enzymes (EL), and low platelet count (LP). It reflects systemic endothelial dysfunction and microangiopathy.

How it's Diagnosed: videos
Blood tests showing hemolysis (schistocytes on blood smear), elevated liver enzymes (AST/ALT), low platelet count (<100,000/µL), and signs of end-organ damage; urine tests for proteinuria; imaging if indicated.

Treatment:
Delivery of the baby as the definitive treatment; supportive care with blood pressure management, magnesium sulfate for seizure prevention, and transfusions (platelets, red blood cells) if necessary.

Medications:
Antihypertensives such as labetalol or nifedipine , magnesium sulfate (anticonvulsant), and corticosteroids (e.g., dexamethasone ) to improve platelet count and fetal lung maturity.

Prevalence: How common the health condition is within a specific population.
Occurs in approximately 0.5-0.9% of pregnancies, often associated with severe preeclampsia.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
History of preeclampsia, multiple pregnancies, obesity, pre-existing hypertension, or autoimmune disorders.

Prognosis: The expected outcome or course of the condition over time.
Favorable with prompt delivery and management; however, maternal and fetal morbidity or mortality risk is higher without early intervention.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Disseminated intravascular coagulation (DIC), liver rupture, kidney failure, stroke, placental abruption, preterm delivery, or maternal and fetal death.

Contrast-Induced Nephropathy

Specialty: Nephrology

Category: Iatrogenic Renal Disorders

Symptoms:
reduced urine output; nausea; fatigue; shortness of breath; swelling in legs or feet

Root Cause:
Administration of contrast media causes direct tubular toxicity, oxidative stress, and renal vasoconstriction, leading to decreased renal function.

How it's Diagnosed: videos
Rise in serum creatinine within 48-72 hours of contrast exposure; urinalysis and imaging may support diagnosis.

Treatment:
Discontinuation of nephrotoxic agents, aggressive hydration with isotonic saline, and supportive care to manage symptoms.

Medications:
Antioxidants like N-acetylcysteine are sometimes used to reduce oxidative damage, though efficacy is debated. Intravenous bicarbonate may also be used to alkalinize urine and reduce toxicity.

Prevalence: How common the health condition is within a specific population.
Occurs in approximately 1-5% of patients with normal kidney function and up to 50% in those with chronic kidney disease.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Chronic kidney disease, diabetes, dehydration, high doses of contrast media, and concurrent use of nephrotoxic drugs.

Prognosis: The expected outcome or course of the condition over time.
Typically reversible with prompt treatment, but severe cases can lead to prolonged kidney injury or chronic kidney disease.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Persistent AKI, need for dialysis, chronic kidney disease, and increased mortality in high-risk patients.

Gastric (Stomach) Cancer

Specialty: Oncology

Category: Solid Tumors

Sub-category: Gastrointestinal Cancers

Symptoms:
abdominal pain or discomfort; nausea; vomiting; loss of appetite; unintended weight loss; bloating; heartburn; melena (black, tarry stools); anemia

Root Cause:
Malignant growth in the stomach lining, often linked to Helicobacter pylori infection, chronic gastritis, or genetic predisposition.

How it's Diagnosed: videos
Upper endoscopy with biopsy, barium swallow, imaging (CT scan, PET scan), and staging laparoscopy in some cases.

Treatment:
Treatment involves surgery (total or partial gastrectomy), chemotherapy, radiation therapy, targeted therapy, or immunotherapy.

Medications:
Medications include chemotherapy agents like fluorouracil , oxaliplatin , and capecitabine ; targeted drugs like trastuzumab (HER2-positive tumors) or ramucirumab (anti-VEGFR2); and immunotherapy like nivolumab (anti-PD-1).

Prevalence: How common the health condition is within a specific population.
Approximately 26,000 cases diagnosed annually in the United States; more common in East Asia, Eastern Europe, and South America.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
H. pylori infection, smoking, high salt intake, diets low in fruits and vegetables, family history, and obesity.

Prognosis: The expected outcome or course of the condition over time.
Prognosis depends on stage; 5-year survival is about 70% for early-stage cancer but less than 30% for advanced disease.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Metastasis, gastrointestinal bleeding, bowel obstruction, or malnutrition following surgery.

Fibrolamellar Hepatocellular Carcinoma

Specialty: Oncology

Category: Solid Tumors

Sub-category: Gastrointestinal Cancers

Symptoms:
abdominal pain; unexplained weight loss; fatigue; nausea; jaundice; lump in the abdomen

Root Cause:
Rare subtype of HCC occurring in young adults without underlying liver disease; linked to DNAJB1-PRKACA fusion mutation.

How it's Diagnosed: videos
Imaging (CT, MRI), biopsy, and liver function tests.

Treatment:
Surgical resection is the main treatment; systemic therapies are less effective, though some targeted therapies are under investigation.

Medications:
No established standard systemic therapy; clinical trials for targeted and immunotherapy drugs are ongoing.

Prevalence: How common the health condition is within a specific population.
Extremely rare, accounting for less than 1% of liver cancers.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Not associated with typical liver cancer risk factors; genetic mutations are implicated.

Prognosis: The expected outcome or course of the condition over time.
Better prognosis than typical HCC if treated early; 5-year survival rates vary based on resectability.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Recurrence after surgery, metastasis to other organs.

Pancreatic Cancer

Specialty: Oncology

Category: Solid Tumors

Sub-category: Gastrointestinal Cancers

Symptoms:
jaundice; upper abdominal pain; unintended weight loss; loss of appetite; nausea; dark urine; pale stools; new-onset diabetes

Root Cause:
Malignant tumor in the pancreas, most commonly pancreatic ductal adenocarcinoma, often associated with genetic mutations or chronic inflammation.

How it's Diagnosed: videos
Imaging (CT scan, MRI, or endoscopic ultrasound), CA 19-9 blood test, and biopsy.

Treatment:
Surgery (Whipple procedure), chemotherapy, radiation, and targeted therapy.

Medications:
Chemotherapy includes gemcitabine and nab-paclitaxel; FOLFIRINOX is used for advanced cases; targeted therapies like olaparib (PARP inhibitor) for BRCA-mutated cancers.

Prevalence: How common the health condition is within a specific population.
Approximately 62,000 cases diagnosed annually in the United States; often diagnosed at advanced stages.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Smoking, chronic pancreatitis, diabetes, obesity, genetic predisposition (e.g., BRCA mutations).

Prognosis: The expected outcome or course of the condition over time.
Poor; 5-year survival rate is about 10% overall, but higher for early-stage resectable tumors.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Metastasis, bile duct obstruction, diabetes, and malnutrition.

Gallbladder Cancer

Specialty: Oncology

Category: Solid Tumors

Sub-category: Gastrointestinal Cancers

Symptoms:
abdominal pain, especially in the upper right quadrant; jaundice; nausea; vomiting; unintended weight loss; loss of appetite; abdominal swelling; fever

Root Cause:
Malignant tumors originating in the gallbladder, often linked to chronic inflammation, gallstones, or genetic mutations.

How it's Diagnosed: videos
Imaging (ultrasound, CT, or MRI), endoscopic retrograde cholangiopancreatography (ERCP), and biopsy.

Treatment:
Treatment includes surgical resection (cholecystectomy), chemotherapy, radiation therapy, and occasionally targeted therapy.

Medications:
Chemotherapy drugs like gemcitabine and cisplatin are commonly used; targeted therapies are being explored in clinical trials.

Prevalence: How common the health condition is within a specific population.
Rare; approximately 12,000 cases diagnosed annually in the United States, with higher prevalence in South America and Southeast Asia.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Gallstones, chronic cholecystitis, obesity, older age, female gender, and a history of bile duct abnormalities.

Prognosis: The expected outcome or course of the condition over time.
Prognosis depends on the stage at diagnosis; 5-year survival is about 65% for localized cancer but less than 10% for advanced stages.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Biliary obstruction, liver metastasis, and malnutrition.

Gastrointestinal Stromal Tumor (GIST)

Specialty: Oncology

Category: Solid Tumors

Sub-category: Gastrointestinal Cancers

Symptoms:
abdominal pain; nausea; vomiting; gastrointestinal bleeding; unintended weight loss; anemia; abdominal swelling

Root Cause:
Rare mesenchymal tumors arising from interstitial cells of Cajal in the gastrointestinal tract, often caused by mutations in the KIT or PDGFRA genes.

How it's Diagnosed: videos
Imaging (CT or MRI), endoscopy with biopsy, and molecular testing for KIT or PDGFRA mutations.

Treatment:
Surgery is the primary treatment for localized tumors; systemic therapy is used for advanced or metastatic cases.

Medications:
Targeted therapy with imatinib (tyrosine kinase inhibitor) is the first-line treatment; sunitinib and regorafenib are used for resistant or advanced cases.

Prevalence: How common the health condition is within a specific population.
Very rare, with an incidence of 4,000-6,000 cases annually in the United States.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
No strong environmental risk factors; some cases are linked to genetic syndromes like neurofibromatosis type 1.

Prognosis: The expected outcome or course of the condition over time.
Excellent for localized tumors treated surgically; 5-year survival rate for metastatic disease is about 50% with effective targeted therapy.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Tumor rupture leading to peritonitis, metastasis (commonly to the liver), and recurrence.

Leiomyosarcoma

Specialty: Oncology

Category: Sarcomas

Sub-category: Soft Tissue Sarcomas

Symptoms:
painful lump; abdominal discomfort (if intra-abdominal); nausea; weight loss; fatigue

Root Cause:
Leiomyosarcoma is a rare malignant tumor that arises from smooth muscle cells, which are found in organs such as the stomach, intestines, and blood vessels.

How it's Diagnosed: videos
Diagnosed through imaging techniques like MRI and CT scans, and confirmed with biopsy for histological examination.

Treatment:
Surgical removal of the tumor is the primary treatment. In some cases, radiation therapy or chemotherapy is used if the tumor cannot be completely resected or if it is metastatic.

Medications:
Chemotherapy drugs such as doxorubicin and ifosfamide are commonly used. These drugs belong to the class of anthracyclines and alkylating agents, respectively, and are employed to treat various sarcomas.

Prevalence: How common the health condition is within a specific population.
Leiomyosarcoma accounts for approximately 10% of all soft tissue sarcomas. It is relatively rare, with an incidence rate of 0.3 per 100,000 people annually.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Previous radiation therapy, age (commonly affects adults), genetic disorders such as hereditary leiomyomatosis.

Prognosis: The expected outcome or course of the condition over time.
Prognosis depends on tumor size, grade, and whether it has spread to other parts of the body. Recurrence is common, and the survival rate is lower for high-grade tumors.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Risk of metastasis to the lungs, complications from surgery, recurrence of the tumor.

Small Intestine Cancer

Specialty: Oncology

Category: Sarcomas

Sub-category: Rare Cancers

Symptoms:
abdominal pain; unexplained weight loss; nausea; vomiting; jaundice; blood in stool; changes in bowel habits; fatigue

Root Cause:
Small intestine cancer develops in the cells of the small intestine, often affecting the epithelial or neuroendocrine cells. The exact cause is unknown, but genetic mutations and conditions like Crohn's disease, celiac disease, and Lynch syndrome can increase the risk.

How it's Diagnosed: videos
Diagnosis is typically through imaging studies like CT scans, MRIs, or endoscopy (e.g., capsule endoscopy or push enteroscopy). Biopsy is used to confirm the diagnosis through histological examination of the tumor tissue.

Treatment:
Treatment involves surgery to remove the tumor if detected early. Chemotherapy (e.g., 5-fluorouracil, capecitabine, or oxaliplatin) is often used for advanced disease. Radiation therapy may be used in some cases. Targeted therapy or immunotherapy may also be considered depending on tumor type.

Medications:
Chemotherapy drugs like 5-fluorouracil (an antimetabolite) and oxaliplatin (a platinum-based chemotherapy drug) are commonly used. Targeted therapies like bevacizumab (an anti-VEGF monoclonal antibody) and immunotherapies such as pembrolizumab (an immune checkpoint inhibitor) may be prescribed for advanced or metastatic cases.

Prevalence: How common the health condition is within a specific population.
Small intestine cancer is very rare, representing less than 2% of all gastrointestinal cancers. Its incidence is estimated to be about 2-3 cases per 100,000 people per year.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Risk factors include genetic conditions such as Lynch syndrome, familial adenomatous polyposis (FAP), and Crohn's disease. Celiac disease and a history of radiation therapy to the abdomen also increase risk.

Prognosis: The expected outcome or course of the condition over time.
The prognosis depends on the stage of the cancer at diagnosis. For localized small intestine cancer, the 5-year survival rate can be as high as 80%, while for metastatic disease, the prognosis is much poorer, with a 5-year survival rate closer to 30%.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Potential complications include bowel obstruction, bleeding, malnutrition, and metastasis to the liver or lymph nodes. In some cases, the cancer can lead to the development of secondary tumors or complications from chemotherapy.

Peritoneal Mesothelioma

Specialty: Oncology

Category: Sarcomas

Sub-category: Rare Cancers

Symptoms:
abdominal pain; swelling in the abdomen; unexplained weight loss; nausea; vomiting; loss of appetite; fatigue; bloating; constipation

Root Cause:
Peritoneal mesothelioma is a rare cancer that affects the peritoneum, the lining of the abdomen. It is most commonly caused by asbestos exposure, which leads to the development of malignant cells that grow and invade the peritoneal lining.

How it's Diagnosed: videos
Diagnosis typically involves imaging studies such as CT scans, MRIs, or ultrasounds to detect fluid buildup (ascites) and tumors in the abdomen. A biopsy is needed for definitive diagnosis, often performed through laparoscopy or peritoneal biopsy.

Treatment:
Treatment options include surgery (e.g., cytoreductive surgery) to remove as much of the tumor as possible, often followed by heated chemotherapy (HIPEC) to target remaining cancer cells. Chemotherapy (e.g., pemetrexed and cisplatin) is used for advanced cases, and radiation therapy may also be applied.

Medications:
Common chemotherapy drugs used to treat peritoneal mesothelioma include pemetrexed (an antifolate drug) and cisplatin (a platinum-based chemotherapy agent). These are used in combination to help shrink tumors and manage the disease. In some cases, targeted therapies or immunotherapy may be considered.

Prevalence: How common the health condition is within a specific population.
Peritoneal mesothelioma is extremely rare, accounting for approximately 10-20% of all mesothelioma cases. The overall incidence is low, with an estimated 300-500 new cases diagnosed annually in the United States.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
The primary risk factor is exposure to asbestos, particularly in occupations like construction, shipbuilding, and manufacturing. Other risk factors include genetic mutations and a history of prior radiation exposure.

Prognosis: The expected outcome or course of the condition over time.
The prognosis for peritoneal mesothelioma is poor, with a median survival rate of 12-24 months, depending on the stage at diagnosis. Patients who undergo cytoreductive surgery with HIPEC may have improved outcomes, but survival is still limited.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Complications include bowel obstruction, ascites (fluid buildup in the abdomen), malnutrition, and metastasis to other parts of the body, particularly the lungs. The treatment itself can also cause side effects like fatigue, nausea, and immune suppression.

Hypercalcemia of Malignancy

Specialty: Oncology

Category: Sarcomas

Sub-category: Paraneoplastic Syndromes

Symptoms:
nausea; vomiting; constipation; abdominal pain; fatigue; confusion; thirst; frequent urination; muscle weakness

Root Cause:
Malignant tumors release calcium into the bloodstream, often through secretion of parathyroid hormone-related protein (PTHrP) or osteolytic bone metastasis.

How it's Diagnosed: videos
Blood tests showing elevated calcium levels, alongside confirmation of underlying malignancy through imaging or biopsy.

Treatment:
Hydration, bisphosphonates (such as zoledronic acid), denosumab, corticosteroids, and calcitonin.

Medications:
Bisphosphonates (e.g., zoledronic acid) inhibit bone resorption, and denosumab , a monoclonal antibody, works by inhibiting osteoclast activity. Corticosteroids (e.g., dexamethasone ) may be used if there is an underlying hematologic malignancy. Calcitonin helps to lower calcium levels by inhibiting osteoclast function.

Prevalence: How common the health condition is within a specific population.
Affects approximately 10-20% of patients with advanced cancer.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Patients with lung, breast, or hematologic cancers, and those with extensive bone metastasis.

Prognosis: The expected outcome or course of the condition over time.
The prognosis depends on the underlying malignancy and the ability to control calcium levels. Treatment of the underlying cancer can improve the prognosis.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Severe hypercalcemia can cause kidney failure, arrhythmias, coma, and, if untreated, death.

Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH)

Specialty: Oncology

Category: Sarcomas

Sub-category: Paraneoplastic Syndromes

Symptoms:
hyponatremia; nausea; vomiting; confusion; seizures; lethargy; muscle cramps

Root Cause:
Tumors produce excess antidiuretic hormone (ADH), leading to water retention and dilutional hyponatremia.

How it's Diagnosed: videos
Blood tests showing low sodium levels and high urine osmolality despite low serum osmolality. Imaging to identify the tumor may also be necessary.

Treatment:
Fluid restriction, hypertonic saline in severe cases, and vasopressin receptor antagonists (e.g., tolvaptan). Treating the underlying cancer may improve SIADH.

Medications:
Vasopressin receptor antagonists (e.g., tolvaptan ) help correct sodium imbalances by blocking the effects of ADH.

Prevalence: How common the health condition is within a specific population.
Common in patients with small cell lung cancer, as well as other malignancies like head and neck cancers.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Small cell lung cancer, brain tumors, and medications such as cyclophosphamide or vincristine.

Prognosis: The expected outcome or course of the condition over time.
Prognosis depends on the underlying malignancy and successful management of fluid imbalances.

Complications: Additional problems or conditions that may arise as a result of the original condition.
If untreated, SIADH can lead to severe hyponatremia, seizures, and coma.

Neuromyelitis Optica (Anti-Aquaporin-4 Antibody Syndrome)

Specialty: Oncology

Category: Sarcomas

Sub-category: Paraneoplastic Syndromes

Symptoms:
vision loss; optic neuritis; nausea; vomiting; paralysis; sensory disturbances; bladder dysfunction; extreme fatigue

Root Cause:
Autoimmune response against aquaporin-4 channels on astrocytes, causing inflammation of the optic nerve and spinal cord, often associated with malignancies.

How it's Diagnosed: videos
Detection of anti-AQP4 antibodies in the blood, MRI showing spinal cord and optic nerve lesions, and clinical presentation.

Treatment:
High-dose corticosteroids, plasmapheresis, and rituximab (an immunosuppressive therapy).

Medications:
Corticosteroids (e.g., methylprednisolone ), rituximab (a monoclonal antibody), and plasmapheresis may be used to manage acute relapses.

Prevalence: How common the health condition is within a specific population.
Rare, with an estimated 2-4 cases per million people annually.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Associated with autoimmune diseases, and may be paraneoplastic in some cases linked to cancers such as breast, lung, and ovarian.

Prognosis: The expected outcome or course of the condition over time.
Relapsing-remitting course in some patients; poor prognosis with significant long-term disability if untreated.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Vision loss, paralysis, and in severe cases, respiratory failure due to spinal cord involvement.

Acute Intermittent Porphyria (AIP)

Specialty: Hematology

Category: Heme Synthesis and Disorders

Symptoms:
abdominal pain; nausea; vomiting; constipation; muscle weakness; confusion; anxiety; seizures; dark-colored urine

Root Cause:
Deficiency of the enzyme porphobilinogen deaminase (PBGD), leading to the accumulation of heme precursors such as delta-aminolevulinic acid (ALA) and porphobilinogen (PBG).

How it's Diagnosed: videos
Measurement of urinary porphobilinogen (PBG) levels during an acute attack; genetic testing to confirm enzyme mutations.

Treatment:
Avoiding triggers (e.g., certain drugs, fasting, stress), intravenous administration of hemin, high carbohydrate intake during attacks.

Medications:
Hemin (a heme analog used to suppress heme synthesis); glucose infusions for mild attacks to inhibit ALA synthase.

Prevalence: How common the health condition is within a specific population.
Affects approximately 1 in 20,000 individuals; more common in women than men.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Female sex, hormonal fluctuations, certain medications (e.g., barbiturates, sulfa drugs), fasting, alcohol consumption.

Prognosis: The expected outcome or course of the condition over time.
With proper management, acute attacks are treatable; however, untreated attacks can lead to complications.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Permanent neurological damage, chronic pain, liver cancer (in rare cases).

ALA Dehydratase Deficiency Porphyria (ALADP)

Specialty: Hematology

Category: Heme Synthesis and Disorders

Symptoms:
severe abdominal pain; nausea; vomiting; neuropathy; weakness; dark-colored urine

Root Cause:
Deficiency of the enzyme ALA dehydratase, resulting in elevated levels of ALA in the plasma and urine.

How it's Diagnosed: videos
Elevated urinary ALA levels, enzyme assays showing low ALA dehydratase activity, genetic testing.

Treatment:
Hemin administration, carbohydrate loading, and avoidance of triggers.

Medications:
Hemin (to downregulate ALA production); glucose infusions for supportive management.

Prevalence: How common the health condition is within a specific population.
Extremely rare, with fewer than 10 reported cases worldwide.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Genetic mutations, exposure to heavy metals (e.g., lead poisoning).

Prognosis: The expected outcome or course of the condition over time.
Chronic management is required to prevent acute attacks; outcomes depend on the severity and frequency of symptoms.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Neurological deficits, kidney damage.

Hereditary Coproporphyria (HCP)

Specialty: Hematology

Category: Heme Synthesis and Disorders

Symptoms:
abdominal pain; nausea; vomiting; neuropathy; photosensitivity; dark urine

Root Cause:
Deficiency of the enzyme coproporphyrinogen oxidase, leading to the accumulation of porphyrins in the liver and plasma.

How it's Diagnosed: videos
Elevated levels of coproporphyrins in urine and stool; genetic testing.

Treatment:
Avoiding triggers, administration of hemin for acute attacks, high carbohydrate intake during symptomatic episodes.

Medications:
Hemin (to inhibit ALA synthase); glucose infusions for mild attacks.

Prevalence: How common the health condition is within a specific population.
Rare, with a prevalence of approximately 1 in 1,000,000.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Family history, hormonal changes, fasting, certain medications (e.g., sulfonamides).

Prognosis: The expected outcome or course of the condition over time.
Treatable; acute episodes can be effectively managed.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Neurological damage, chronic pain, photosensitivity-related skin damage.

Castleman Disease

Specialty: Hematology

Category: Lymphoproliferative Disorders

Symptoms:
enlarged lymph nodes; fatigue; fever; night sweats; unintended weight loss; weakness; nausea; abdominal or chest pain

Root Cause:
Lymph node hyperplasia due to dysregulated immune responses. May be idiopathic or associated with viral infections such as human herpesvirus 8 (HHV-8).

How it's Diagnosed: videos
Diagnosis involves lymph node biopsy, imaging studies (CT or PET scans), blood tests to detect inflammation markers, and tests for HHV-8 and HIV.

Treatment:
Treatment depends on the subtype (unicentric or multicentric). Unicentric disease is treated with surgical removal of the affected lymph node, while multicentric disease often requires systemic therapy.

Medications:
Siltuximab (monoclonal antibody targeting IL-6). Rituximab (monoclonal antibody targeting CD20, especially for HHV-8–positive cases). Corticosteroids (to reduce inflammation). Chemotherapeutic agents (e.g., cyclophosphamide , doxorubicin ). Antiviral medications (e.g., ganciclovir for HHV-8 infections). These medications include biologics, immunomodulators, and chemotherapeutic agents.

Prevalence: How common the health condition is within a specific population.
Rare; incidence is estimated at 21–25 cases per million per year.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Infection with human herpesvirus 8 (HHV-8), HIV infection, and possibly autoimmune conditions.

Prognosis: The expected outcome or course of the condition over time.
Prognosis for unicentric disease is excellent after surgical excision, while prognosis for multicentric disease varies based on the underlying cause, age, and treatment response.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Complications may include organ dysfunction, infection due to immunosuppression, progression to lymphoma, and systemic inflammatory response syndrome (SIRS).

Intravenous Immunoglobulin (IVIG) Therapy

Specialty: Hematology

Category: Immunotherapy

Symptoms:
fever; fatigue; rash; nausea; muscle aches (side effects of ivig administration)

Root Cause:
Utilized to modulate the immune response or replace deficient antibodies in immune-mediated conditions or primary immunodeficiencies.

How it's Diagnosed: videos
Indications based on clinical presentations such as immune thrombocytopenia, Kawasaki disease, or primary immunodeficiency; laboratory confirmation of low immunoglobulin levels.

Treatment:
Intravenous infusion of pooled immunoglobulins from healthy donors; dose and frequency vary depending on the condition.

Medications:
Immunoglobulin preparations (e.g., Gammagard , Privigen , Octagam ).

Prevalence: How common the health condition is within a specific population.
Widely used in clinical practice for various immune-mediated and immunodeficient conditions.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Autoimmune diseases, genetic immunodeficiencies, or secondary immunosuppression.

Prognosis: The expected outcome or course of the condition over time.
Often effective in managing immune-mediated conditions or replacing deficient antibodies.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Allergic reactions, thromboembolism, renal dysfunction, aseptic meningitis.

Acetaminophen (Paracetamol) Toxicity

Specialty: Toxicology

Category: Acute Poisoning

Sub-category: Pharmaceutical Overdoses

Symptoms:
nausea; vomiting; abdominal pain; jaundice; confusion; fatigue

Root Cause:
Excessive intake of acetaminophen overwhelms liver detoxification pathways, leading to toxic accumulation of N-acetyl-p-benzoquinone imine (NAPQI), a metabolite that causes liver damage.

How it's Diagnosed: videos
Diagnosed with serum acetaminophen levels and liver function tests.

Treatment:
Treated with N-acetylcysteine (NAC) to replenish glutathione and prevent liver damage.

Medications:
N-acetylcysteine (NAC) is the antidote for acetaminophen toxicity. It belongs to the class of mucolytics and glutathione precursors.

Prevalence: How common the health condition is within a specific population.
Acetaminophen toxicity is one of the most common causes of acute liver failure globally, with thousands of cases reported annually.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Overdose (intentional or accidental), chronic alcohol use, malnutrition, or concurrent use of medications that induce cytochrome P450 enzymes (e.g., certain anticonvulsants).

Prognosis: The expected outcome or course of the condition over time.
Good if treated promptly; severe cases can lead to acute liver failure and death if untreated.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Acute liver failure, hepatic encephalopathy, kidney injury, and death in severe cases.

Aspirin (Salicylate) Poisoning

Specialty: Toxicology

Category: Acute Poisoning

Sub-category: Pharmaceutical Overdoses

Symptoms:
nausea; vomiting; hyperventilation; ringing in the ears (tinnitus); confusion; seizures; coma

Root Cause:
Excessive salicylates disrupt metabolic pathways, causing respiratory alkalosis, metabolic acidosis, and increased energy expenditure.

How it's Diagnosed: videos
Diagnosed by serum salicylate levels and blood gas analysis

Treatment:
Treated with activated charcoal, IV sodium bicarbonate for alkalinization, and hemodialysis in severe cases.

Medications:
Sodium bicarbonate is used to alkalinize urine; it is an alkalinizing agent. No specific antidote exists.

Prevalence: How common the health condition is within a specific population.
Less common due to decreased aspirin use in children but still a concern in adults and intentional overdoses.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Intentional overdose, chronic use, impaired kidney function, or co-ingestion with other medications.

Prognosis: The expected outcome or course of the condition over time.
Good with early treatment; severe cases can result in multi-organ failure and death.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Pulmonary edema, cerebral edema, seizures, and renal failure.

Organophosphate and carbamate insecticide poisoning

Specialty: Toxicology

Category: Acute Poisoning

Sub-category: Chemical Poisoning

Symptoms:
nausea; vomiting; diarrhea; salivation; lacrimation (tearing); urination; muscle twitching; confusion; seizures; respiratory distress; bradycardia; miosis (pupil constriction)

Root Cause:
Inhibition of acetylcholinesterase enzyme, leading to an accumulation of acetylcholine at synapses and overstimulation of the nervous system.

How it's Diagnosed: videos
Clinical history of exposure, symptoms presentation, blood cholinesterase levels (low levels indicate poisoning).

Treatment:
Decontamination (removal of contaminated clothing, washing skin), administration of atropine (to counteract muscarinic effects) and pralidoxime (to reactivate acetylcholinesterase), supportive care (oxygen, fluids).

Medications:
Atropine (anticholinergic agent), pralidoxime (cholinesterase reactivator), benzodiazepines (e.g., diazepam or lorazepam ) for seizures.

Prevalence: How common the health condition is within a specific population.
Common in agricultural regions where these insecticides are widely used; estimated to cause hundreds of thousands of poisonings annually worldwide.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Occupational exposure (farmers, pesticide applicators), improper storage or handling, intentional ingestion (suicide attempt).

Prognosis: The expected outcome or course of the condition over time.
Favorable with prompt treatment; delayed treatment can lead to severe complications or death.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Respiratory failure, prolonged muscle weakness (intermediate syndrome), long-term neurological dysfunction.

Methanol and ethylene glycol poisoning

Specialty: Toxicology

Category: Acute Poisoning

Sub-category: Chemical Poisoning

Symptoms:
nausea; vomiting; abdominal pain; blurred vision; seizures; altered mental status; metabolic acidosis; renal failure

Root Cause:
Toxic metabolites (formic acid from methanol, oxalate crystals from ethylene glycol) cause metabolic acidosis and organ damage (e.g., optic nerve in methanol poisoning, kidneys in ethylene glycol poisoning).

How it's Diagnosed: videos
Clinical history, elevated anion gap metabolic acidosis, osmolar gap, specific blood levels of methanol or ethylene glycol.

Treatment:
Administration of fomepizole or ethanol (inhibits alcohol dehydrogenase), bicarbonate therapy for acidosis, hemodialysis for severe cases, folinic acid or pyridoxine (cofactors to detoxify metabolites).

Medications:
Fomepizole (alcohol dehydrogenase inhibitor), ethanol (alternative alcohol dehydrogenase substrate), bicarbonate (neutralizes acidosis), folinic acid (enhances formic acid detoxification in methanol poisoning).

Prevalence: How common the health condition is within a specific population.
Sporadic cases, commonly associated with accidental ingestion or intentional poisoning.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Ingestion of antifreeze, windshield washer fluid, or contaminated alcohol.

Prognosis: The expected outcome or course of the condition over time.
Good with early treatment; delays can lead to permanent blindness or renal damage.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Blindness (methanol), renal failure (ethylene glycol), metabolic acidosis, multi-organ failure.

Carbon monoxide poisoning

Specialty: Toxicology

Category: Acute Poisoning

Sub-category: Chemical Poisoning

Symptoms:
headache; dizziness; nausea; vomiting; confusion; chest pain; shortness of breath; loss of consciousness; seizures; coma

Root Cause:
Carbon monoxide binds to hemoglobin with greater affinity than oxygen, forming carboxyhemoglobin, which reduces oxygen delivery to tissues and causes cellular hypoxia.

How it's Diagnosed: videos
Clinical history, carboxyhemoglobin levels via blood gas analysis, pulse CO-oximetry (if available).

Treatment:
Removal from exposure source, administration of 100% oxygen, hyperbaric oxygen therapy in severe cases.

Medications:
No specific medications; 100% oxygen or hyperbaric oxygen therapy is the treatment of choice.

Prevalence: How common the health condition is within a specific population.
Common, particularly in poorly ventilated areas with gas heaters, car exhaust, or during fire incidents.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Indoor use of gas appliances, fires, motor vehicle exhaust, faulty heating systems.

Prognosis: The expected outcome or course of the condition over time.
Excellent with early treatment; delayed treatment can result in neurological sequelae or death.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Hypoxic brain injury, delayed neuropsychiatric syndrome (DNS), arrhythmias, myocardial ischemia.

Hydrofluoric acid toxicity

Specialty: Toxicology

Category: Acute Poisoning

Sub-category: Chemical Poisoning

Symptoms:
severe pain at the exposure site; redness or whitish discoloration of the skin; swelling; nausea; vomiting; cardiac arrhythmias; hypocalcemia; muscle spasms; weakness

Root Cause:
Hydrofluoric acid penetrates tissues deeply, dissociating into hydrogen and fluoride ions. The fluoride ions bind calcium and magnesium, disrupting cellular function and leading to systemic toxicity.

How it's Diagnosed: videos
Clinical history of exposure, symptoms presentation, serum calcium, magnesium, and potassium levels, ECG (to detect arrhythmias).

Treatment:
Immediate washing of the skin with water, application of calcium gluconate gel to neutralize fluoride ions, intravenous calcium gluconate for systemic toxicity, supportive care.

Medications:
Calcium gluconate (topical and intravenous), magnesium supplements, pain relievers (e.g., opioids for severe pain).

Prevalence: How common the health condition is within a specific population.
Rare, typically associated with industrial settings or accidental exposure.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Industrial exposure (e.g., glass etching, rust removal, cleaning agents), inadequate safety measures.

Prognosis: The expected outcome or course of the condition over time.
Good with prompt treatment; severe exposure can result in systemic toxicity or death.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Hypocalcemia, hyperkalemia, cardiac arrhythmias, tissue necrosis, systemic toxicity.

Chlorine gas exposure

Specialty: Toxicology

Category: Acute Poisoning

Sub-category: Chemical Poisoning

Symptoms:
coughing; shortness of breath; chest tightness; burning sensation in the throat and eyes; wheezing; nausea; vomiting; pulmonary edema

Root Cause:
Chlorine gas reacts with water in the respiratory tract to form hydrochloric acid and hypochlorous acid, causing irritation and damage to respiratory tissues.

How it's Diagnosed: videos
Clinical history of exposure, symptoms presentation, chest X-ray or CT scan to assess lung damage.

Treatment:
Removal from exposure, supportive care with oxygen therapy, bronchodilators for wheezing, corticosteroids for severe inflammation.

Medications:
Bronchodilators (e.g., albuterol ), corticosteroids (e.g., prednisone ), oxygen therapy.

Prevalence: How common the health condition is within a specific population.
Sporadic cases, often associated with industrial accidents or improper mixing of cleaning agents.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Industrial exposure, household accidents, swimming pool maintenance (chlorine release).

Prognosis: The expected outcome or course of the condition over time.
Good with early treatment; severe exposure can lead to chronic respiratory issues.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Reactive airway dysfunction syndrome (RADS), chronic bronchitis, pulmonary edema.

Synthetic cannabinoids toxicity

Specialty: Toxicology

Category: Acute Poisoning

Sub-category: Chemical Poisoning

Symptoms:
confusion; anxiety; paranoia; seizures; hypertension; nausea; vomiting; chest pain

Root Cause:
Overactivation of cannabinoid receptors by synthetic chemicals, leading to unpredictable and exaggerated physiological and psychological effects.

How it's Diagnosed: videos
History of synthetic cannabinoid use, clinical symptoms, and toxicology testing (though specific detection is often limited).

Treatment:
Supportive care, benzodiazepines for agitation or seizures, antiemetics for nausea, and cardiovascular monitoring.

Medications:
Benzodiazepines (e.g., lorazepam ) for agitation and seizures; antiemetics like ondansetron for nausea and vomiting.

Prevalence: How common the health condition is within a specific population.
Increasingly reported due to the availability of synthetic cannabinoids as a legal alternative to cannabis in some regions.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Use of synthetic cannabinoids, mixing with other substances, and lack of knowledge about the specific chemical consumed.

Prognosis: The expected outcome or course of the condition over time.
Most cases resolve with supportive care, but severe toxicity can lead to life-threatening complications.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Acute kidney injury, seizures, psychosis, and cardiac arrhythmias.

LSD and hallucinogen-related toxicity

Specialty: Toxicology

Category: Acute Poisoning

Sub-category: Chemical Poisoning

Symptoms:
hallucinations; anxiety; paranoia; tachycardia; hypertension; dilated pupils; nausea; psychosis

Root Cause:
Overactivation of serotonin receptors in the brain, leading to altered perception, mood, and cognition.

How it's Diagnosed: videos
Clinical evaluation and history of hallucinogen use; toxicology testing may help exclude other substances.

Treatment:
Supportive care, benzodiazepines for agitation or psychosis, and observation in a calm environment.

Medications:
Benzodiazepines (e.g., lorazepam ) for severe agitation or psychosis; antipsychotics (e.g., haloperidol ) if benzodiazepines are insufficient.

Prevalence: How common the health condition is within a specific population.
Hallucinogen use is less common than other recreational drugs but can lead to significant toxicity in high doses.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
High-dose use, preexisting mental health disorders, and polydrug use.

Prognosis: The expected outcome or course of the condition over time.
Generally favorable with supportive care, but psychological complications may persist.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Persistent psychosis, hallucination-persisting perception disorder (HPPD), and traumatic injuries during hallucinations.

Methanol Poisoning

Specialty: Toxicology

Category: Acute Poisoning

Sub-category: Alcohol-Related Toxicity

Symptoms:
headache; nausea; vomiting; blurred vision; metabolic acidosis; confusion; seizures; blindness; coma

Root Cause:
Metabolism of methanol to formic acid leads to severe metabolic acidosis and optic nerve toxicity.

How it's Diagnosed: videos
Measurement of serum methanol levels, metabolic acidosis with increased anion and osmolal gap, and clinical symptoms.

Treatment:
Administration of fomepizole or ethanol to inhibit alcohol dehydrogenase, correction of acidosis with bicarbonate, and hemodialysis to remove methanol and formic acid.

Medications:
Fomepizole or ethanol (alcohol dehydrogenase inhibitors); sodium bicarbonate for acidosis.

Prevalence: How common the health condition is within a specific population.
Rare; occurs due to ingestion of adulterated alcohol or industrial exposure.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Access to methanol-containing products, substance misuse, occupational hazards.

Prognosis: The expected outcome or course of the condition over time.
With early treatment, prognosis is good; delayed treatment can result in blindness or death.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Permanent blindness, multi-organ failure, death.

Ethylene Glycol Poisoning

Specialty: Toxicology

Category: Acute Poisoning

Sub-category: Alcohol-Related Toxicity

Symptoms:
nausea; vomiting; abdominal pain; metabolic acidosis; seizures; kidney failure; coma

Root Cause:
Metabolism of ethylene glycol to toxic metabolites (glycolic acid, oxalic acid) causes metabolic acidosis, renal toxicity, and crystalluria.

How it's Diagnosed: videos
Elevated anion and osmolal gap, presence of calcium oxalate crystals in urine, serum ethylene glycol levels.

Treatment:
Fomepizole or ethanol to inhibit alcohol dehydrogenase, bicarbonate for acidosis, and hemodialysis for severe poisoning.

Medications:
Fomepizole or ethanol (alcohol dehydrogenase inhibitors); pyridoxine and thiamine may support metabolism.

Prevalence: How common the health condition is within a specific population.
Uncommon; typically involves accidental or intentional ingestion of antifreeze.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Access to ethylene glycol-containing products, substance misuse, occupational exposure.

Prognosis: The expected outcome or course of the condition over time.
Good with early treatment; delayed or untreated cases often result in severe renal damage or death.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Acute kidney injury, metabolic acidosis, neurological damage, death.

Arsenic Poisoning

Specialty: Toxicology

Category: Chronic Toxicity and Long-Term Exposures

Sub-category: Heavy Metal Toxicity

Symptoms:
nausea; vomiting; abdominal pain; diarrhea; darkened skin patches; thickened skin on palms and soles; fatigue; peripheral neuropathy; confusion; muscle cramps

Root Cause:
Accumulation of arsenic in the body due to exposure to contaminated drinking water, industrial processes, or arsenic-containing pesticides. Arsenic disrupts cellular metabolism, DNA repair, and oxidative processes.

How it's Diagnosed: videos
Diagnosis is made through urine arsenic levels (preferred for recent exposure) or hair and nail analysis for chronic exposure. Clinical symptoms and exposure history are also key.

Treatment:
Treatment includes cessation of exposure, supportive care for symptoms, and chelation therapy for severe cases. Ensuring access to safe water sources is critical.

Medications:
Chelating agents such as dimercaprol and succimer (DMSA) are used to bind arsenic and enhance excretion. The choice of medication depends on the severity of poisoning.

Prevalence: How common the health condition is within a specific population.
Arsenic poisoning is prevalent in regions with contaminated groundwater, particularly in South Asia (e.g., Bangladesh, India) and parts of South America.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Drinking arsenic-contaminated water, occupational exposure (e.g., smelting, mining), use of arsenic-based pesticides, and ingestion of contaminated food.

Prognosis: The expected outcome or course of the condition over time.
Early intervention and cessation of exposure can lead to symptom improvement. However, prolonged exposure can result in irreversible damage and increased cancer risk.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Long-term complications include skin lesions, peripheral neuropathy, cardiovascular diseases, diabetes, and increased risks of cancers (e.g., skin, lung, bladder).

Cadmium Poisoning

Specialty: Toxicology

Category: Chronic Toxicity and Long-Term Exposures

Sub-category: Heavy Metal Toxicity

Symptoms:
nausea; vomiting; abdominal pain; diarrhea; shortness of breath; cough; weakness; bone pain; renal dysfunction (proteinuria); osteomalacia

Root Cause:
Cadmium exposure occurs primarily through inhalation of fumes or dust (e.g., in industrial settings) or ingestion of contaminated food or water. Cadmium accumulates in the kidneys and bones, leading to oxidative stress, cellular damage, and impaired calcium metabolism.

How it's Diagnosed: videos
Diagnosis is made by measuring cadmium levels in blood or urine. Renal function tests (e.g., urinary protein levels) and bone density studies are often conducted to assess long-term damage.

Treatment:
Treatment includes removing the source of cadmium exposure, supportive care for symptoms, and chelation therapy in severe cases. Calcium and vitamin D supplementation may be recommended for bone health.

Medications:
Chelating agents like dimercaprol and EDTA (ethylenediaminetetraacetic acid) may be used in cases of severe poisoning. Chelation is less effective for chronic exposure due to cadmium's strong tissue binding.

Prevalence: How common the health condition is within a specific population.
Cadmium poisoning is more common in industrial workers (e.g., battery manufacturing, metal plating) and populations exposed to contaminated food or water, particularly in areas with poor environmental regulations.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Occupational exposure (e.g., smelting, welding), smoking (tobacco contains cadmium), consumption of cadmium-contaminated food (e.g., rice, shellfish), and living near industrial sites.

Prognosis: The expected outcome or course of the condition over time.
Early removal from exposure can improve outcomes, but chronic exposure may result in irreversible kidney damage, bone demineralization, and other complications.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Long-term complications include chronic kidney disease (CKD), osteoporosis, fractures, respiratory disorders (e.g., emphysema), and an increased risk of cancers (e.g., lung, prostate).

Chromium Toxicity

Specialty: Toxicology

Category: Chronic Toxicity and Long-Term Exposures

Sub-category: Heavy Metal Toxicity

Symptoms:
skin ulcers; rash; respiratory issues (cough, wheezing); abdominal pain; nausea; vomiting; fatigue; headaches; cognitive impairment; kidney damage; liver dysfunction

Root Cause:
Chromium toxicity occurs through inhalation of chromium-containing dust or fumes (commonly in industrial settings), or ingestion of contaminated food or water. Chromium (especially hexavalent chromium) is a potent carcinogen and irritates tissues, leading to cellular and organ damage.

How it's Diagnosed: videos
Diagnosis is based on measuring chromium levels in urine, blood, or sputum. Occupational history and clinical symptoms are key, particularly in those with chronic exposure.

Treatment:
Treatment involves removal from exposure, supportive care for symptoms, and possible chelation therapy for high chromium levels. Bronchodilators may be used for respiratory symptoms.

Medications:
Chelating agents like dimercaprol, EDTA, and penicillamine can be used to help remove chromium from the body in cases of severe poisoning. However, chromium toxicity primarily requires supportive management and removal of the exposure source.

Prevalence: How common the health condition is within a specific population.
Chromium toxicity is more common in individuals working in industries like metal plating, welding, and leather tanning, as well as those exposed to contaminated water sources.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Occupational exposure (e.g., metal plating, cement production, leather tanning), environmental contamination, living near industrial sites, and consuming water contaminated with hexavalent chromium.

Prognosis: The expected outcome or course of the condition over time.
The prognosis depends on the severity of exposure and the timeliness of medical intervention. Chronic exposure can lead to irreversible lung damage, kidney failure, and an increased risk of cancer.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Long-term complications include respiratory diseases (e.g., lung cancer, asthma), kidney and liver damage, skin ulcers, and gastrointestinal issues. Chronic exposure may also lead to an increased risk of cancers, particularly lung and gastrointestinal cancers.

Pesticide Poisoning (Chronic Exposure)

Specialty: Toxicology

Category: Chronic Toxicity and Long-Term Exposures

Sub-category: Occupational and Environmental Exposures

Symptoms:
headache; nausea; fatigue; memory loss; mood changes; peripheral neuropathy; respiratory issues; dermatitis

Root Cause:
Chronic exposure to pesticides leads to bioaccumulation, oxidative stress, and neurotoxicity, potentially affecting multiple organ systems.

How it's Diagnosed: videos
Patient history, blood/urine analysis for pesticide metabolites, and neurological assessments.

Treatment:
Removing the source of exposure, supportive care, antioxidant therapy, and chelation therapy in some cases.

Medications:
Atropine (an anticholinergic) and pralidoxime (a cholinesterase reactivator) are used for organophosphate poisoning. Antioxidants like vitamin E and N-acetylcysteine may mitigate oxidative damage.

Prevalence: How common the health condition is within a specific population.
Prevalent among agricultural workers and individuals in areas of high pesticide use.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Occupational exposure, inadequate protective equipment, and prolonged exposure.

Prognosis: The expected outcome or course of the condition over time.
Varies based on severity and duration of exposure; long-term effects can include neurological deficits and chronic respiratory conditions.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Neurological disorders, endocrine disruption, infertility, and cancer.

Polycyclic Aromatic Hydrocarbons (PAHs) Exposure

Specialty: Toxicology

Category: Chronic Toxicity and Long-Term Exposures

Sub-category: Occupational and Environmental Exposures

Symptoms:
skin irritation; respiratory issues; fatigue; headache; nausea; chronic cough

Root Cause:
Bioactivation of PAHs into reactive metabolites causes DNA damage, oxidative stress, and inflammation.

How it's Diagnosed: videos
Biomonitoring of PAHs metabolites in urine or blood, occupational and environmental history, and imaging studies for organ-specific symptoms.

Treatment:
Avoiding exposure, dietary antioxidants, symptomatic treatment, and monitoring for cancer development.

Medications:
No specific medications; supportive care and antioxidants like vitamin C and glutathione precursors may help reduce oxidative damage.

Prevalence: How common the health condition is within a specific population.
Common among industrial workers, smokers, and those living in polluted environments.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Exposure to combustion products, industrial processes, smoking, and dietary intake of charred foods.

Prognosis: The expected outcome or course of the condition over time.
Chronic exposure increases cancer risk (lung, skin, bladder). Early cessation of exposure improves outcomes.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Cancer, chronic respiratory diseases, and immune dysfunction.

Solvent Toxicity (e.g., Benzene, Toluene)

Specialty: Toxicology

Category: Chronic Toxicity and Long-Term Exposures

Sub-category: Occupational and Environmental Exposures

Symptoms:
headache; dizziness; confusion; memory loss; nausea; fatigue; respiratory distress; skin irritation

Root Cause:
Prolonged exposure to solvents causes central nervous system depression, bone marrow suppression, and organ toxicity.

How it's Diagnosed: videos
Blood tests for solvent levels or metabolites, bone marrow biopsy, and neurological assessments.

Treatment:
Avoidance of exposure, supportive care, and treating complications (e.g., bone marrow suppression).

Medications:
Chelating agents like dimercaprol or succimer may be used for heavy solvent exposure with metal components. Symptomatic treatments include antiemetics for nausea or anxiolytics for agitation.

Prevalence: How common the health condition is within a specific population.
Found in industrial settings (painting, printing, chemical production); exposure is common globally.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Occupational exposure, inadequate ventilation, improper handling of solvents.

Prognosis: The expected outcome or course of the condition over time.
Varies with exposure level; chronic exposure may lead to irreversible organ damage or cancer.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Leukemia (benzene exposure), kidney or liver damage, and neurological disorders.

Acute Radiation Syndrome (ARS)

Specialty: Toxicology

Category: Chronic Toxicity and Long-Term Exposures

Sub-category: Radiation Exposure

Symptoms:
nausea; vomiting; diarrhea; skin burns; hair loss; weakness; bleeding; infections

Root Cause:
Damage to rapidly dividing cells and tissues due to high-dose ionizing radiation exposure over a short period.

How it's Diagnosed: videos
Medical history of radiation exposure, symptoms onset, blood tests (lymphocyte count), and dosimetry (measuring radiation dose received).

Treatment:
Supportive care (hydration, pain management, and infection control), growth factors to stimulate bone marrow recovery, blood transfusions, antibiotics, and stem cell transplantation in severe cases.

Medications:
Growth factors like filgrastim (granulocyte colony-stimulating factor, G-CSF) to promote white blood cell recovery; anti-nausea medications such as ondansetron (serotonin antagonist); antibiotics or antifungals for infection control; potassium iodide to block thyroid uptake of radioactive iodine.

Prevalence: How common the health condition is within a specific population.
Rare; typically occurs after nuclear accidents, medical radiation mishaps, or radiation weapon exposure.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Proximity to nuclear explosions or accidents, occupational exposure without proper protective measures, and participation in nuclear weaponry-related activities.

Prognosis: The expected outcome or course of the condition over time.
Varies by radiation dose; low to moderate doses may allow recovery, while high doses can lead to fatal organ failure within days to weeks.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Secondary infections, hemorrhage, organ failure, and long-term risks of cancer due to DNA damage.

Toxic effects of solvents (e.g., paint thinners, glues)

Specialty: Toxicology

Category: Acute and Chronic Toxicity

Sub-category: Industrial Chemicals and Solvents

Symptoms:
dizziness; headache; confusion; nausea; vomiting; dermatitis; irritation of the respiratory system; fatigue; memory impairment with chronic exposure

Root Cause:
Solvents cause toxicity through inhalation, ingestion, or skin absorption, leading to damage to the central nervous system, respiratory system, and skin. Chronic exposure can result in neurotoxicity.

How it's Diagnosed: videos
Diagnosis is based on exposure history, clinical symptoms, imaging (e.g., chest X-ray or MRI for neurological effects), and laboratory tests to detect solvent metabolites in blood or urine.

Treatment:
Immediate treatment involves removing the person from exposure, providing supportive care, oxygen therapy for respiratory distress, and treating systemic effects. Skin exposure requires thorough washing.

Medications:
Medications depend on symptoms

Prevalence: How common the health condition is within a specific population.
Common among industrial workers, painters, and individuals using glue for recreational inhalation ("huffing").

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Occupational exposure, recreational inhalant use, inadequate protective measures, and prolonged use in poorly ventilated spaces.

Prognosis: The expected outcome or course of the condition over time.
Acute exposures often resolve with appropriate care, but chronic exposure may lead to irreversible neurological damage.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Peripheral neuropathy, chronic headaches, liver damage, and kidney damage.

Ricin poisoning (castor bean plant)

Specialty: Toxicology

Category: Biological and Natural Toxins

Sub-category: Plant Toxins

Symptoms:
nausea; vomiting; diarrhea; abdominal pain; severe dehydration; organ failure; difficulty breathing (if inhaled); seizures

Root Cause:
Ricin is a highly toxic protein that inhibits protein synthesis at the cellular level, causing cell death and widespread tissue damage.

How it's Diagnosed: videos
Clinical history of exposure (e.g., ingestion, inhalation, or injection of castor beans); confirmed with laboratory tests for ricin in blood, urine, or environmental samples.

Treatment:
Supportive care (IV fluids, mechanical ventilation for respiratory distress, medications to manage organ failure), decontamination (activated charcoal for ingestion), and symptomatic treatment.

Medications:
No specific antidote exists for ricin. Supportive treatments may include anti-seizure medications (benzodiazepines like lorazepam ), anti-inflammatory drugs, and oxygen therapy.

Prevalence: How common the health condition is within a specific population.
Rare; typically associated with accidental ingestion or intentional poisoning.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Handling or ingesting castor beans, occupational exposure (e.g., castor oil production).

Prognosis: The expected outcome or course of the condition over time.
Depends on dose and route of exposure; severe cases without prompt treatment can be fatal. Survival is possible with early supportive care.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Respiratory failure, kidney failure, multi-organ dysfunction, death in severe cases.

Foxglove (digitalis) toxicity

Specialty: Toxicology

Category: Biological and Natural Toxins

Sub-category: Plant Toxins

Symptoms:
nausea; vomiting; diarrhea; abdominal pain; confusion; visual disturbances (e.g., seeing halos around lights); irregular heart rhythms

Root Cause:
Digitalis compounds interfere with sodium-potassium ATPase in cardiac cells, leading to increased intracellular calcium and altered heart function.

How it's Diagnosed: videos
Clinical presentation, history of foxglove exposure or ingestion, and elevated serum digoxin levels.

Treatment:
Activated charcoal (if ingestion is recent), digoxin-specific antibody fragments (Digibind), and management of arrhythmias (e.g., with anti-arrhythmic drugs or temporary pacing).

Medications:
Digibind (digoxin-specific antibody fragments); anti-arrhythmics like lidocaine may be used for ventricular arrhythmias.

Prevalence: How common the health condition is within a specific population.
Rare in modern contexts; usually due to accidental ingestion or misuse of foxglove extracts.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Accidental ingestion, herbal remedy misuse, or overdose of digoxin-containing medications.

Prognosis: The expected outcome or course of the condition over time.
Good with early recognition and treatment; severe cases can be life-threatening.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Life-threatening arrhythmias, cardiac arrest, neurological complications (e.g., seizures).

Snake venom poisoning

Specialty: Toxicology

Category: Biological and Natural Toxins

Sub-category: Animal Toxins

Symptoms:
pain at the bite site; swelling; difficulty breathing; nausea; vomiting; dizziness; weakness; blurred vision; bleeding; paralysis

Root Cause:
Envenomation by the venom of a snake, which contains proteins that can damage tissue, blood vessels, and organs.

How it's Diagnosed: videos
Diagnosis is based on clinical signs and symptoms, the type of snake (if known), and laboratory tests like blood clotting studies, complete blood count (CBC), and snake venom detection kits.

Treatment:
Antivenom administration is the primary treatment, along with supportive care such as fluid management, pain relief, and respiratory support.

Medications:
The main treatment is antivenom, which is a specific antibody designed to neutralize venom toxins. Pain relief can be managed with opioids or non-steroidal anti-inflammatory drugs (NSAIDs), depending on the severity of the pain. In severe cases, corticosteroids may be used to reduce inflammation and swelling. Anticoagulants may be used for clotting issues, and antibiotics may be given if secondary infections are a concern.

Prevalence: How common the health condition is within a specific population.
Worldwide, approximately 5.4 million cases of snakebite occur annually, with about 100,000 deaths.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Proximity to snake habitats, agricultural work, lack of access to medical care, and unawareness of proper snakebite prevention.

Prognosis: The expected outcome or course of the condition over time.
If treated promptly with antivenom and appropriate medical care, the prognosis is generally good. However, severe envenomations can cause lasting damage or death.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Severe complications may include tissue necrosis, renal failure, hemorrhage, paralysis, and death. Long-term effects may include limb amputations, kidney dysfunction, or chronic pain.

Spider bites (e.g., black widow, brown recluse)

Specialty: Toxicology

Category: Biological and Natural Toxins

Sub-category: Animal Toxins

Symptoms:
localized pain; muscle cramps; sweating; nausea; vomiting; fever; chills; skin necrosis; tissue damage

Root Cause:
Venom injection from spiders containing neurotoxins or cytotoxins, leading to local and systemic symptoms.

How it's Diagnosed: videos
Diagnosis is based on clinical presentation and history of exposure to venomous spiders. In some cases, laboratory tests may be used to detect systemic effects of envenomation.

Treatment:
Treatment involves pain management, wound care, and, in severe cases, antivenom or muscle relaxants. Surgery may be needed for extensive tissue damage from brown recluse bites.

Medications:
For black widow spider bites, antivenom may be used for severe cases. Pain relief medications such as acetaminophen or NSAIDs are typically prescribed. Muscle relaxants like benzodiazepines may be used for severe muscle cramps, while corticosteroids can reduce inflammation. In cases of skin necrosis, antibiotics or even surgical intervention may be required.

Prevalence: How common the health condition is within a specific population.
In the U.S., there are approximately 2,500 to 3,000 cases of black widow bites and 1,000 to 2,000 cases of brown recluse bites annually.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Living in areas where venomous spiders are common, being outdoors at night, or disturbing spider habitats.

Prognosis: The expected outcome or course of the condition over time.
Most spider bites are not fatal and can be managed with appropriate medical care. Severe cases may lead to long-term scarring, particularly with brown recluse bites.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Tissue necrosis, systemic symptoms like hypertension or respiratory distress, and secondary infections can occur, especially in immunocompromised individuals.

Marine envenomations (e.g., jellyfish, stonefish, cone snail)

Specialty: Toxicology

Category: Biological and Natural Toxins

Sub-category: Animal Toxins

Symptoms:
pain or stinging sensation; swelling; nausea; vomiting; difficulty breathing; paralysis; heart arrhythmias; skin lesions

Root Cause:
Envenomation by marine organisms that release toxins into the body, affecting the nervous system, cardiovascular system, or causing local tissue damage.

How it's Diagnosed: videos
Diagnosis is based on the history of exposure to marine creatures, clinical presentation, and identification of the specific venomous species involved.

Treatment:
Treatment includes immediate first aid (e.g., rinsing with vinegar for jellyfish stings, immersion in hot water), pain relief, and administration of specific antivenoms or supportive care. In some cases, defibrillation or respiratory support may be required.

Medications:
Jellyfish stings may be treated with analgesics (NSAIDs or acetaminophen ) for pain. For severe envenomations, antivenom may be administered. Other medications could include corticosteroids to reduce inflammation, and calcium gluconate for specific marine toxins like stonefish venom. Muscle relaxants and antiarrhythmics may be used for severe systemic effects.

Prevalence: How common the health condition is within a specific population.
Marine envenomations are common in coastal areas, with jellyfish stings alone resulting in millions of cases annually, especially in tropical regions.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Swimming in areas known for venomous marine life, lack of awareness, and seasonal variation in marine toxin release.

Prognosis: The expected outcome or course of the condition over time.
The prognosis depends on the species involved and the severity of the envenomation. Most cases are mild, but severe reactions can cause long-term complications or be fatal.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Respiratory failure, cardiac arrhythmias, neurological damage, and, in extreme cases, death. Secondary infections or permanent scarring may occur due to skin lesions.

Mycotoxin exposure (e.g., aflatoxins from mold)

Specialty: Toxicology

Category: Biological and Natural Toxins

Sub-category: Bacterial and Fungal Toxins

Symptoms:
nausea; vomiting; abdominal pain; fatigue; jaundice; liver damage; immunosuppression

Root Cause:
Mycotoxins, such as aflatoxins produced by molds (Aspergillus species), can contaminate food and cause toxic effects, especially on the liver.

How it's Diagnosed: videos
Diagnosis involves testing food or body fluids (e.g., urine, blood) for the presence of specific mycotoxins. Liver function tests may show signs of damage.

Treatment:
There is no specific antidote for mycotoxin poisoning. Treatment is supportive and involves addressing liver damage, detoxification, and managing symptoms.

Medications:
"Activated charcoal " (used in the treatment of poisonings, classified as an adsorbent to prevent toxin absorption), "liver protectants" (such as silymarin or N-acetylcysteine), "antioxidants" (to reduce oxidative damage).

Prevalence: How common the health condition is within a specific population.
Aflatoxins affect millions of people globally, especially in developing countries with poor agricultural practices, with exposure often through contaminated food like peanuts, maize, and grains.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Poor food storage, high humidity, warm temperatures, and poor agricultural practices leading to fungal contamination.

Prognosis: The expected outcome or course of the condition over time.
Long-term exposure to mycotoxins can lead to chronic liver damage, including cirrhosis and liver cancer, but acute poisoning may resolve with supportive care.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Chronic liver disease, immunosuppression, increased risk of liver cancer, and death in severe cases.

Ciguatera Fish Poisoning

Specialty: Toxicology

Category: Biological and Natural Toxins

Sub-category: Foodborne and Natural Toxins

Symptoms:
nausea; vomiting; diarrhea; abdominal pain; muscle weakness; numbness; tingling in limbs; temperature reversal (cold objects feel hot, and hot objects feel cold); fatigue

Root Cause:
Toxins (ciguatoxins) produced by marine dinoflagellates accumulate in certain fish species, causing symptoms after ingestion.

How it's Diagnosed: videos
Diagnosis is primarily clinical, based on history of fish consumption and characteristic symptoms. Confirmation is difficult, but urine or blood tests may detect ciguatoxins, though they are not routinely available.

Treatment:
Treatment is supportive, including hydration, pain management, and anti-nausea medications. There is no specific antidote for ciguatera poisoning.

Medications:
Symptomatic medications may include antihistamines, antiemetics (e.g., ondansetron ), and analgesics for pain relief (e.g., acetaminophen or ibuprofen ). In severe cases, intravenous fluids may be required. Some case reports suggest using mannitol (a diuretic) for neurological symptoms, though this is controversial.

Prevalence: How common the health condition is within a specific population.
Ciguatera poisoning is more common in tropical and subtropical regions, especially in the Pacific Islands, Caribbean, and coastal areas of Southeast Asia.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Consumption of large reef fish (e.g., barracuda, grouper, snapper), especially from tropical or subtropical waters.

Prognosis: The expected outcome or course of the condition over time.
Most people recover fully within weeks to months, but some may experience persistent neurological symptoms (e.g., temperature reversal) for months or years.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Long-term neurological effects, such as persistent numbness, tingling, and temperature sensation reversal. Rare cases may have cardiovascular complications such as arrhythmias.

Scombroid Poisoning

Specialty: Toxicology

Category: Biological and Natural Toxins

Sub-category: Foodborne and Natural Toxins

Symptoms:
flushing; rash; headache; abdominal cramps; diarrhea; nausea; vomiting; burning or metallic taste

Root Cause:
Histamine accumulation in fish (typically tuna, mackerel, or sardines) due to improper storage or handling, leading to an allergic-like reaction.

How it's Diagnosed: videos
Diagnosis is based on clinical symptoms and history of eating improperly stored fish. Laboratory tests for elevated histamine levels in the fish can help confirm the diagnosis.

Treatment:
Antihistamines (e.g., diphenhydramine) for symptom relief, and in severe cases, epinephrine may be required for anaphylaxis-like reactions.

Medications:
Antihistamines (e.g., diphenhydramine , loratadine ) are typically prescribed. In some cases, corticosteroids or epinephrine may be used for severe reactions.

Prevalence: How common the health condition is within a specific population.
It is more common in warm climates, particularly in tropical and subtropical regions, affecting people who consume improperly stored or handled fish.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Consumption of poorly refrigerated or improperly stored scombroid fish species.

Prognosis: The expected outcome or course of the condition over time.
Generally good with prompt treatment. Symptoms often resolve within a few hours to a day.

Complications: Additional problems or conditions that may arise as a result of the original condition.
In severe cases, anaphylaxis may occur, requiring immediate medical attention.

Paralytic Shellfish Poisoning

Specialty: Toxicology

Category: Biological and Natural Toxins

Sub-category: Foodborne and Natural Toxins

Symptoms:
numbness; tingling; dizziness; weakness; paralysis; respiratory distress; difficulty swallowing; nausea; vomiting

Root Cause:
Toxins (saxitoxins) produced by certain marine algae accumulate in shellfish (e.g., clams, mussels, oysters), leading to poisoning after consumption.

How it's Diagnosed: videos
Diagnosis is based on clinical presentation and history of shellfish consumption from affected areas. Laboratory tests can detect saxitoxins in shellfish, blood, or urine.

Treatment:
There is no specific antidote. Treatment is supportive, including respiratory support (e.g., mechanical ventilation) in severe cases. Activated charcoal may be used if ingestion is recent.

Medications:
No specific medications are used, but supportive care involves fluids, respiratory support, and sometimes atropine for bradycardia. Antihistamines and antiemetics may be used for mild cases.

Prevalence: How common the health condition is within a specific population.
Occurs primarily in coastal regions where shellfish harvesting occurs. Prevalence can vary depending on local algal blooms.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Consumption of shellfish during bloom seasons when high levels of toxins are present.

Prognosis: The expected outcome or course of the condition over time.
The prognosis depends on the severity of symptoms. Most individuals recover within hours to days if treated promptly.

Complications: Additional problems or conditions that may arise as a result of the original condition.
In severe cases, respiratory failure, paralysis, or death can occur due to respiratory muscle paralysis.

Amanita Mushroom Poisoning

Specialty: Toxicology

Category: Biological and Natural Toxins

Sub-category: Foodborne and Natural Toxins

Symptoms:
nausea; vomiting; abdominal pain; diarrhea; jaundice; liver failure; renal failure; confusion; seizures

Root Cause:
The ingestion of Amanita mushrooms, especially species like Amanita phalloides (death cap), which contain potent toxins (amatoxins) that damage the liver and kidneys.

How it's Diagnosed: videos
Diagnosis is based on clinical history (ingestion of suspected mushrooms), clinical symptoms, and laboratory tests (e.g., liver function tests, mushroom identification). Detection of amatoxins in urine may confirm diagnosis.

Treatment:
Treatment involves supportive care (e.g., intravenous fluids, liver dialysis), and in severe cases, liver transplantation may be required. Antidotes like silibinin (milk thistle extract) and N-acetylcysteine may help.

Medications:
Antidotes such as silibinin (a liver protectant) and N-acetylcysteine (used for liver support) may be prescribed. In some cases, activated charcoal is used if the mushroom was ingested recently.

Prevalence: How common the health condition is within a specific population.
Amanita mushroom poisoning is rare but serious, often occurring during the mushroom-picking season, typically in temperate climates.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Mushroom foraging, especially by individuals who may confuse toxic species with edible ones. Lack of mushroom identification expertise.

Prognosis: The expected outcome or course of the condition over time.
If treated early, the prognosis may be improved. However, poisoning can lead to severe liver and kidney damage or death if not addressed promptly.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Liver failure, renal failure, long-term organ damage, and death in severe cases.

Chemotherapy-related toxicity (e.g., cisplatin, doxorubicin)

Specialty: Toxicology

Category: Adverse Effects of Therapeutics and Medical Agents

Sub-category: Drug-Induced Toxicity

Symptoms:
nausea; vomiting; fatigue; anemia; peripheral neuropathy; hearing loss (ototoxicity); cardiotoxicity; renal dysfunction

Root Cause:
Chemotherapy agents damage both cancerous and healthy cells, leading to systemic toxicity. Cisplatin causes renal and ototoxicity, while doxorubicin is known for cardiotoxicity.

How it's Diagnosed: videos
Clinical symptoms, laboratory tests (renal function, cardiac markers), audiometry (for hearing loss), and imaging studies (e.g., echocardiogram for cardiotoxicity).

Treatment:
Symptomatic management, dose adjustment or discontinuation of the chemotherapy agent, and supportive measures like hydration for renal protection or use of cardioprotective agents.

Medications:
Medications to mitigate toxicity include amifostine (cytoprotective agent), dexrazoxane (cardioprotective for doxorubicin ), antiemetics like ondansetron , and growth factors like filgrastim to manage neutropenia.

Prevalence: How common the health condition is within a specific population.
Common among patients undergoing chemotherapy; up to 90% may experience some degree of toxicity.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
High cumulative dose, pre-existing kidney or heart conditions, older age, and genetic predisposition.

Prognosis: The expected outcome or course of the condition over time.
Variable depending on severity; early recognition and management improve outcomes. Some toxicities may be irreversible, such as hearing loss or chronic heart failure.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Chronic kidney disease, heart failure, irreversible neuropathy, or secondary malignancies.

Nonsteroidal anti-inflammatory drug (NSAID) toxicity

Specialty: Toxicology

Category: Adverse Effects of Therapeutics and Medical Agents

Sub-category: Drug-Induced Toxicity

Symptoms:
gastric pain; nausea; vomiting; gastrointestinal bleeding; acute kidney injury; hyperkalemia

Root Cause:
NSAIDs inhibit cyclooxygenase enzymes, reducing prostaglandin synthesis, which compromises gastric mucosal protection, renal perfusion, and platelet aggregation.

How it's Diagnosed: videos
Clinical history, laboratory tests (renal function, electrolytes), stool tests for occult blood, and imaging for gastrointestinal perforations.

Treatment:
Discontinuation of NSAIDs, proton pump inhibitors (e.g., omeprazole) for gastric protection, IV fluids for renal support, and treatment of complications like anemia or bleeding.

Medications:
Proton pump inhibitors (e.g., omeprazole ), misoprostol (for gastric mucosal protection), or activated charcoal (in acute overdose).

Prevalence: How common the health condition is within a specific population.
Common; NSAID-related adverse effects are seen in up to 25% of chronic users.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Long-term use, high doses, older age, concurrent anticoagulant or corticosteroid use, and pre-existing kidney or gastrointestinal conditions.

Prognosis: The expected outcome or course of the condition over time.
Good with early management; severe complications like GI perforation or kidney failure can be life-threatening.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Peptic ulcer disease, gastrointestinal perforation, chronic kidney disease, or cardiovascular events.

Radiation therapy-induced toxicity

Specialty: Toxicology

Category: Adverse Effects of Therapeutics and Medical Agents

Sub-category: Iatrogenic Conditions

Symptoms:
skin burns; fatigue; nausea; vomiting; dry mouth; difficulty swallowing; pneumonitis; esophagitis

Root Cause:
The ionizing radiation used in cancer therapy causes damage to normal healthy tissues, leading to acute or chronic inflammation and cellular damage.

How it's Diagnosed: videos
Diagnosis is based on clinical symptoms, timing in relation to radiation therapy, and imaging findings; biopsy or laboratory tests may be used to assess tissue damage.

Treatment:
Management involves corticosteroids, anti-nausea medications, pain relief, and symptomatic management of skin or mucosal irritation. Depending on the affected organ, more specific treatments may be required (e.g., antibiotics for radiation pneumonitis).

Medications:
Corticosteroids (e.g., prednisone , dexamethasone ) are used to reduce inflammation, anti-nausea drugs (e.g., ondansetron ), pain relievers, and sometimes antibiotics or immunosuppressants for more severe reactions.

Prevalence: How common the health condition is within a specific population.
Radiation-induced toxicity is a common complication, though its severity depends on the type and location of radiation therapy.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
High radiation doses, field size, proximity of radiation to critical organs, underlying health conditions (e.g., diabetes, heart disease), and concurrent chemotherapy.

Prognosis: The expected outcome or course of the condition over time.
Most toxicity symptoms resolve after treatment; however, long-term or permanent tissue damage can occur, especially with high doses.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Chronic fatigue, fibrosis, secondary cancers, esophageal stenosis, and pulmonary issues.

Contrast-induced nephropathy (from imaging studies)

Specialty: Toxicology

Category: Adverse Effects of Therapeutics and Medical Agents

Sub-category: Iatrogenic Conditions

Symptoms:
acute kidney dysfunction; decreased urine output; swelling; nausea; vomiting; fatigue

Root Cause:
Contrast agents used in imaging studies can cause kidney damage, typically through direct toxicity to the renal tubular cells or through causing vasoconstriction, reducing blood flow to the kidneys.

How it's Diagnosed: videos
Diagnosis involves assessing kidney function through serum creatinine levels, urine output, and the timing of symptoms in relation to contrast exposure. Imaging may also show signs of kidney damage.

Treatment:
The mainstay of treatment is supportive care, which includes hydration, monitoring kidney function, and possibly using diuretics in some cases. Dialysis may be required in severe cases.

Medications:
N-acetylcysteine (a potential preventive measure), bicarbonate infusions (to alkalinize urine and prevent nephropathy), and diuretics (e.g., furosemide ) may be used if necessary to manage kidney function.

Prevalence: How common the health condition is within a specific population.
Contrast-induced nephropathy occurs in approximately 2-5% of patients exposed to contrast media, though this varies with the population studied and the type of contrast used.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Pre-existing renal disease, dehydration, diabetes, older age, use of high-osmolar contrast agents, and concurrent use of nephrotoxic drugs.

Prognosis: The expected outcome or course of the condition over time.
Most patients recover with appropriate management, but some may develop chronic kidney disease or require dialysis.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Chronic kidney disease, electrolyte imbalances, and in rare cases, kidney failure.

Pesticide Residue Exposure

Specialty: Toxicology

Category: Toxic Effects of Environmental Pollutants

Sub-category: Soil and Agricultural Toxins

Symptoms:
nausea; vomiting; dizziness; headache; fatigue; skin irritation; respiratory issues

Root Cause:
Chronic or acute exposure to pesticide residues on food, in water, or in the environment leads to the accumulation of toxic substances in the body, potentially causing cellular and systemic damage.

How it's Diagnosed: videos
Diagnosed through patient history, physical examination, and laboratory tests, such as blood and urine tests to detect pesticide metabolites or biomarkers.

Treatment:
Immediate treatment involves removing the source of exposure, administering activated charcoal or gastric lavage (in acute cases), and providing supportive care for symptoms. Long-term management includes chelation therapy in severe cases and reducing exposure through dietary and environmental modifications.

Medications:
No specific antidotes for most pesticide exposures. Symptomatic treatments include atropine (anticholinergic for organophosphate poisoning), pralidoxime (cholinesterase reactivator for certain organophosphate toxicities), and anti-nausea medications such as ondansetron .

Prevalence: How common the health condition is within a specific population.
Common in agricultural regions; widespread globally due to the use of pesticides in farming. The World Health Organization estimates millions of cases of pesticide poisoning annually, with thousands of deaths.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Occupational exposure (farmers, agricultural workers), consuming non-organic produce, proximity to areas with heavy pesticide use, inadequate protective measures during pesticide application.

Prognosis: The expected outcome or course of the condition over time.
Prognosis depends on the level and duration of exposure. Acute poisoning has a good prognosis with timely treatment, but chronic exposure may result in long-term health effects, including neurological and endocrine disorders.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Chronic toxicity can lead to endocrine disruption, neurodegenerative diseases, cancer, reproductive issues, and developmental delays in children.

Herbicide Toxicity (e.g., Glyphosate)

Specialty: Toxicology

Category: Toxic Effects of Environmental Pollutants

Sub-category: Soil and Agricultural Toxins

Symptoms:
skin irritation; burning sensation in the throat; difficulty breathing; nausea; vomiting; abdominal pain; diarrhea

Root Cause:
Exposure to herbicides like glyphosate causes cellular damage through oxidative stress and disruption of enzyme systems critical for normal physiological function. Ingestion of concentrated formulations may lead to corrosive injury.

How it's Diagnosed: videos
Diagnosed through patient history, clinical presentation, and laboratory tests to detect glyphosate or its metabolites in blood or urine. Imaging studies may assess organ damage in severe cases.

Treatment:
Supportive care includes decontamination (removal of contaminated clothing, washing skin), gastric lavage for ingestion, intravenous fluids, and monitoring of respiratory and renal function. Activated charcoal may be administered to reduce absorption.

Medications:
No specific antidote is available . Symptomatic treatments include antiemetics (e.g., ondansetron ), proton pump inhibitors (e.g., omeprazole ) to reduce gastric irritation, and analgesics (e.g., acetaminophen ) for pain relief. Dialysis may be required for renal failure.

Prevalence: How common the health condition is within a specific population.
Herbicide exposure is common in agricultural communities and areas where herbicides are heavily used. Glyphosate is one of the most widely used herbicides globally. Accidental or occupational exposure affects thousands annually.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Occupational exposure, improper handling or storage of herbicides, lack of protective equipment during application, accidental ingestion, and contamination of drinking water or food.

Prognosis: The expected outcome or course of the condition over time.
Mild exposure typically resolves with supportive care. Severe exposure can lead to life-threatening complications but has a favorable prognosis with timely medical intervention.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Acute toxicity may cause corrosive injuries to the gastrointestinal tract, respiratory failure, renal impairment, and, in severe cases, cardiovascular collapse. Chronic exposure is associated with an increased risk of cancer, endocrine disruption, and developmental issues.

Uremia (toxins from kidney failure)

Specialty: Toxicology

Category: Endogenous Toxins

Sub-category: Metabolic Disorders

Symptoms:
nausea; vomiting; fatigue; loss of appetite; mental confusion; seizures; muscle cramps; itching; breath with a urine-like odor

Root Cause:
Accumulation of uremic toxins and waste products in the bloodstream due to impaired kidney function, leading to systemic toxicity.

How it's Diagnosed: videos
Blood tests showing elevated blood urea nitrogen (BUN) and creatinine levels; electrolyte imbalances; clinical symptoms; sometimes confirmed with imaging or biopsy of kidneys.

Treatment:
Immediate treatment often involves dialysis (hemodialysis or peritoneal dialysis) to remove toxins, along with addressing the underlying cause (e.g., managing kidney disease or acute kidney injury).

Medications:
Medications to manage symptoms and complications include antihypertensive drugs (e.g., ACE inhibitors like lisinopril or ARBs like losartan ), phosphate binders (e.g., sevelamer ), erythropoiesis-stimulating agents (e.g., epoetin alfa) to manage anemia, and diuretics (e.g., furosemide ) to reduce fluid overload.

Prevalence: How common the health condition is within a specific population.
Common among patients with chronic kidney disease (CKD), especially in end-stage renal disease (ESRD). Affects approximately 15% of the global population with CKD.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Chronic kidney disease, diabetes, hypertension, recurrent urinary tract infections, genetic predisposition, nephrotoxic medications.

Prognosis: The expected outcome or course of the condition over time.
Treatable with dialysis or kidney transplant; prognosis depends on the underlying cause and overall health of the patient. Without treatment, it can be fatal.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Heart disease, fluid overload, pericarditis, electrolyte imbalances (e.g., hyperkalemia), neuropathy, bone disease.

Porphyria-related toxicity

Specialty: Toxicology

Category: Endogenous Toxins

Sub-category: Hematologic Disorders

Symptoms:
abdominal pain; nausea; vomiting; constipation; dark urine; seizures; muscle weakness; anxiety; hallucinations

Root Cause:
Accumulation of porphyrins or their precursors due to a defect in the heme biosynthesis pathway, leading to neurotoxicity and other systemic effects.

How it's Diagnosed: videos
Urine and blood tests for porphyrins and precursors (e.g., aminolevulinic acid, porphobilinogen); genetic testing to identify specific mutations.

Treatment:
Glucose infusions or hemin administration to suppress heme biosynthesis, along with supportive care to manage symptoms. Avoidance of triggering factors such as certain medications or fasting.

Medications:
Hemin (synthetic heme, used to downregulate porphyrin production), glucose (for metabolic support).

Prevalence: How common the health condition is within a specific population.
Rare, with an estimated prevalence of 1 in 25,000 to 1 in 50,000 for acute porphyrias.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Family history, use of triggering medications (e.g., barbiturates, sulfonamides), alcohol consumption, hormonal changes (e.g., during menstruation).

Prognosis: The expected outcome or course of the condition over time.
With early diagnosis and management, symptoms are reversible, but severe attacks can lead to long-term complications or death.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Chronic pain, paralysis, kidney failure, liver damage, severe neurological deficits.

Rhabdomyolysis-related toxicity (myoglobin release)

Specialty: Toxicology

Category: Endogenous Toxins

Sub-category: Pathologic Toxins

Symptoms:
muscle pain; weakness; dark-colored urine; fatigue; swelling; nausea; confusion; irregular heart rhythms in severe cases; muscle pain; weakness; dark-colored urine; fatigue

Root Cause:
The breakdown of skeletal muscle releases myoglobin and other intracellular contents, leading to kidney damage and metabolic disturbances.

How it's Diagnosed: videos
Elevated creatine kinase (CK) levels, myoglobin in the urine, blood tests for electrolyte imbalances, and kidney function tests.

Treatment:
Aggressive intravenous fluid therapy to maintain urine output, correction of electrolyte imbalances, dialysis in severe kidney failure, and treating underlying causes.us fluid therapy to maintain urine output, correction of electrolyte imbalances, dialysis in severe kidney failure, and treating und

Medications:
No specific medications; supportive treatments include sodium bicarbonate or mannitol to alkalinize urine and prevent myoglobin toxicity. Electrolyte management may require potassium binders or calcium gluconate.

Prevalence: How common the health condition is within a specific population.
Varies depending on the cause; commonly associated with trauma, extreme exercise, drug use, or infections. Incidence estimated at 26,000 cases annually in the U.S.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Traumatic injuries, prolonged immobility, heatstroke, excessive exercise, certain medications (e.g., statins, fibrates), or toxins.

Prognosis: The expected outcome or course of the condition over time.
Favorable with early treatment, but severe cases can lead to acute kidney injury (AKI) or death if untreated.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Acute kidney failure, hyperkalemia, metabolic acidosis, compartment syndrome, and disseminated intravascular coagulation (DIC).

Suicide attempts via pharmaceutical or chemical agents

Specialty: Toxicology

Category: Deliberate and Accidental Poisoning

Sub-category: Intentional Overdoses

Symptoms:
altered mental status; respiratory depression; seizures; nausea; vomiting; abdominal pain; cardiac arrhythmias; coma

Root Cause:
Ingestion of toxic doses of medications (e.g., sedatives, opioids, antidepressants) or chemicals (e.g., household cleaners, industrial substances) causes systemic toxicity and organ dysfunction.

How it's Diagnosed: videos
Clinical history (when available), physical examination, toxicology screens (blood and urine), serum drug levels, and imaging studies (if structural damage is suspected).

Treatment:
Stabilization (airway, breathing, circulation), decontamination (e.g., activated charcoal if appropriate), specific antidotes (e.g., naloxone for opioids), symptomatic management (e.g., anti-seizure medications), and supportive care (e.g., IV fluids, mechanical ventilation).

Medications:
Antidotes such as naloxone (opioid antagonist), flumazenil (benzodiazepine antagonist), and N-acetylcysteine (for acetaminophen overdose); sedatives like benzodiazepines (anticonvulsants) for seizures; and IV fluids for dehydration and hypotension.

Prevalence: How common the health condition is within a specific population.
Suicide attempts via pharmaceutical or chemical agents account for approximately 10-20% of emergency toxicology cases worldwide, with variations depending on region and accessibility to medications or chemicals.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
History of mental health disorders (e.g., depression, anxiety), access to toxic substances, substance abuse, prior suicide attempts, and social stressors.

Prognosis: The expected outcome or course of the condition over time.
Prognosis depends on the type and amount of substance ingested, time to treatment, and overall health of the individual. With timely intervention, most cases are survivable. Delayed or inadequate treatment may lead to significant morbidity or mortality.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Organ failure (e.g., liver or kidney damage), aspiration pneumonia, prolonged hospital stays, chronic neurological deficits, and death.

Accidental industrial chemical exposure

Specialty: Toxicology

Category: Occupational and Environmental Poisoning

Sub-category: Accidental Exposure

Symptoms:
skin irritation; respiratory distress; dizziness; nausea; burning sensation in eyes or throat; headache; confusion

Root Cause:
Unintended exposure to toxic chemicals (e.g., solvents, pesticides, cleaning agents) due to improper handling, leaks, or accidents in industrial settings.

How it's Diagnosed: videos
History of exposure, physical examination, toxicological screening, and air or substance sampling to identify specific chemicals.

Treatment:
Removal from exposure source, decontamination (e.g., flushing eyes or skin), supportive care (e.g., oxygen for respiratory distress), and specific antidotes if needed.

Medications:
Oxygen therapy, bronchodilators (e.g., albuterol for respiratory symptoms), corticosteroids for inflammation, or antidotes like atropine (for organophosphate poisoning). Atropine is an anticholinergic agent.

Prevalence: How common the health condition is within a specific population.
Highly variable; depends on workplace safety protocols and the type of industry. Common in agriculture, manufacturing, and chemical processing industries.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Poor industrial safety measures, lack of personal protective equipment (PPE), inadequate training on chemical handling.

Prognosis: The expected outcome or course of the condition over time.
Varies widely; mild exposures resolve with treatment, but severe cases (e.g., toxic inhalation or burns) can lead to long-term health issues or death.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Chronic lung disease, neurological impairment, organ damage, cancer (from long-term exposure to carcinogenic chemicals).

Food contamination-related poisoning

Specialty: Toxicology

Category: Environmental and Ingestional Poisoning

Sub-category: Foodborne Poisoning

Symptoms:
nausea; vomiting; diarrhea; abdominal cramps; fever; dehydration

Root Cause:
Ingestion of food contaminated by bacteria (e.g., Salmonella, E. coli), viruses (e.g., norovirus), toxins (e.g., aflatoxins), or chemicals (e.g., pesticides).

How it's Diagnosed: videos
Clinical history of food consumption, stool tests for pathogens, and testing for toxins or chemicals in food samples.

Treatment:
Supportive care (e.g., hydration, electrolyte replacement), antibiotics if bacterial infection is identified, or antitoxins for specific poisonings.

Medications:
Antibiotics (e.g., ciprofloxacin for bacterial infections like Salmonella), antiemetics (e.g., ondansetron ), and oral rehydration solutions. Ciprofloxacin is a fluoroquinolone antibiotic.

Prevalence: How common the health condition is within a specific population.
Affects millions annually worldwide; particularly common in areas with inadequate food safety measures.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Poor food hygiene, contaminated water, improper food storage or preparation, consumption of raw or undercooked food.

Prognosis: The expected outcome or course of the condition over time.
Generally good with treatment; most cases resolve within days, but severe cases can lead to hospitalization or death.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Severe dehydration, hemolytic uremic syndrome (HUS) from E. coli, chronic gastrointestinal issues, or systemic infections.

Mustard gas exposure

Specialty: Toxicology

Category: Miscellaneous Toxicological Conditions

Sub-category: Chemical Terrorism and Warfare Agents

Symptoms:
skin irritation and blistering; eye irritation and corneal damage; respiratory tract damage; nausea; vomiting; bone marrow suppression

Root Cause:
Mustard gas alkylates DNA, causing cellular damage, especially in rapidly dividing tissues such as the skin, mucosa, and bone marrow.

How it's Diagnosed: videos
Clinical diagnosis based on signs and symptoms of exposure; laboratory testing of air, soil, or biological samples may confirm presence of the agent.

Treatment:
Decontamination of skin and eyes, supportive care, administration of antibiotics for secondary infections, and management of bone marrow suppression with growth factors or transfusions.

Medications:
Antibiotics (varied classes) - Used to treat secondary bacterial infections of skin or lungs. Granulocyte colony-stimulating factor (G-CSF) - Stimulates bone marrow recovery in cases of suppression. Analgesics (non-opioid or opioid) - Provide pain relief from skin or respiratory damage.

Prevalence: How common the health condition is within a specific population.
Rare, limited to chemical warfare or accidental exposures in research or storage facilities.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Lack of protective equipment, proximity to affected areas, inadequate decontamination procedures.

Prognosis: The expected outcome or course of the condition over time.
Prognosis depends on exposure level and supportive care; long-term complications may include chronic respiratory disease, scarring, or cancer.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Infections, respiratory failure, chronic obstructive pulmonary disease (COPD), scarring, increased cancer risk.

Heavy metal contamination in traditional remedies

Specialty: Toxicology

Category: Miscellaneous Toxicological Conditions

Sub-category: Herbal and Alternative Medicine Toxicity

Symptoms:
abdominal pain; nausea; vomiting; diarrhea; headache; fatigue; cognitive impairment; kidney dysfunction; anemia; peripheral neuropathy

Root Cause:
Presence of toxic heavy metals (e.g., lead, mercury, arsenic, cadmium) in traditional or alternative remedies due to contamination or intentional adulteration during manufacturing.

How it's Diagnosed: videos
Blood and urine tests to detect heavy metal levels; clinical history of remedy use; imaging or organ function tests for damage assessment.

Treatment:
Immediate discontinuation of the remedy; chelation therapy for heavy metal removal; supportive care for symptoms and organ damage management.

Medications:
Chelating agents such as dimercaprol (a chelating agent for arsenic , mercury, and lead poisoning), succimer (an oral chelator for lead poisoning), and calcium disodium EDTA (used for lead chelation therapy).

Prevalence: How common the health condition is within a specific population.
Prevalence varies geographically but is significant in regions with widespread use of unregulated traditional remedies.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Use of imported or locally made traditional remedies, lack of regulatory oversight, cultural reliance on alternative medicine, and socioeconomic factors limiting access to conventional healthcare.

Prognosis: The expected outcome or course of the condition over time.
Prognosis depends on the level and duration of exposure; early intervention improves outcomes, while delayed treatment may lead to irreversible organ damage or chronic health issues.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Chronic kidney disease, neurotoxicity, developmental delays in children, anemia, cardiovascular issues, and increased cancer risk (e.g., arsenic-related carcinogenesis).

Toxic effects of unregulated supplements

Specialty: Toxicology

Category: Miscellaneous Toxicological Conditions

Sub-category: Dietary Supplement and Nutraceutical Toxicity

Symptoms:
nausea; vomiting; liver dysfunction; kidney damage; cardiac arrhythmias; neurological symptoms; metabolic imbalances

Root Cause:
Adverse reactions to unregulated dietary supplements due to contamination, overdoses of active ingredients, or interactions with other medications.

How it's Diagnosed: videos
Comprehensive clinical history, including supplement usage; blood tests for liver and kidney function; toxicology screening for contaminants or active substances.

Treatment:
Immediate cessation of the supplement; supportive care for organ damage; treatment of specific toxicities (e.g., electrolyte management for metabolic imbalances).

Medications:
Treatment depends on the toxicity but may include N-acetylcysteine for liver injury (e.g., acetaminophen-like toxicity), activated charcoal for acute ingestions, or electrolyte replacement therapies.

Prevalence: How common the health condition is within a specific population.
Growing prevalence due to the global increase in dietary supplement use, with up to 25% of users experiencing some adverse effects.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Use of supplements from unregulated sources, lack of proper dosing information, concurrent use of multiple supplements, pre-existing medical conditions, and inadequate consumer education.

Prognosis: The expected outcome or course of the condition over time.
Most cases are reversible with early intervention; severe or prolonged exposure may lead to lasting organ damage or increased mortality.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Liver failure, acute kidney injury, cardiotoxicity, metabolic disturbances, allergic reactions, and interaction-induced adverse effects with prescription medications.

Withdrawal syndromes

Specialty: Toxicology

Category: Miscellaneous Toxicological Conditions

Sub-category: Substance Use and Abuse

Symptoms:
anxiety; restlessness; insomnia; nausea; vomiting; sweating; seizures; hallucinations; cravings; muscle pain; tremors

Root Cause:
Withdrawal occurs due to abrupt cessation or reduction in the use of a substance, disrupting the brain's adaptive changes to the drug.

How it's Diagnosed: videos
Clinical evaluation of history, substance use patterns, and physical/psychological symptoms; sometimes aided by withdrawal severity scales.

Treatment:
Gradual tapering of the substance, medications to manage symptoms, supportive care, and behavioral therapy.

Medications:
Alcohol withdrawal - Benzodiazepines (e.g., diazepam , lorazepam ) to prevent seizures and delirium tremens. Opioid withdrawal - Methadone , buprenorphine , or clonidine to manage symptoms and cravings. Nicotine withdrawal - Nicotine replacement therapy (patches, gum), varenicline , or bupropion .

Prevalence: How common the health condition is within a specific population.
Withdrawal syndromes are common among individuals with substance dependence, with prevalence varying based on substance use patterns.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Prolonged or heavy substance use, abrupt cessation, lack of medical supervision during detoxification.

Prognosis: The expected outcome or course of the condition over time.
Prognosis depends on the substance, duration of use, and treatment adherence; most symptoms resolve with treatment, though cravings and relapse risk may persist.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Severe complications include seizures, delirium tremens (in alcohol withdrawal), dehydration, cardiac arrhythmias, and suicide risk.

Inhalant-Related Psychiatric Disorders

Specialty: Mental Health and Psychology

Category: Addiction

Symptoms:
euphoria; dizziness; slurred speech; lethargy; nausea; impaired coordination; mood changes; confusion; cognitive deficits

Root Cause:
Inhalants disrupt brain function by affecting neurotransmitter systems and causing hypoxia, leading to cognitive and behavioral impairments.

How it's Diagnosed: videos
Clinical history of inhalant use, behavioral assessment, and signs of exposure such as chemical odors or physical indicators (e.g., burns, rashes around the nose or mouth).

Treatment:
Psychotherapy, cognitive-behavioral therapy (CBT), and addressing co-occurring psychiatric disorders.

Medications:
No specific medications approved; supportive care may include anti-anxiety medications like SSRIs (e.g., sertraline ) for comorbid anxiety.

Prevalence: How common the health condition is within a specific population.
Inhalant use is most common among adolescents, with 2.7% of high school students reporting use within the past year.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Adolescence, access to volatile substances, low socioeconomic status, peer influence, underlying mental health disorders.

Prognosis: The expected outcome or course of the condition over time.
Early intervention can lead to recovery; prolonged use can cause irreversible neurological and cognitive damage.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Brain damage, organ failure, hypoxic injuries, and sudden sniffing death syndrome (SSDS).

Selective Serotonin Reuptake Inhibitor (SSRI) Toxicity

Specialty: Mental Health and Psychology

Category: Emergency

Sub-category: Medication Toxicity

Symptoms:
agitation; confusion; tremors; hyperreflexia; tachycardia; sweating; nausea; diarrhea; seizures; hyperthermia

Root Cause:
Excessive serotonin activity in the central nervous system due to overdose or interaction with other serotonergic drugs.

How it's Diagnosed: videos
Clinical diagnosis based on history of SSRI use and presentation of symptoms consistent with serotonin syndrome. Rule out other causes like infection or withdrawal.

Treatment:
Discontinuation of the SSRI, supportive care (hydration, cooling measures for hyperthermia), benzodiazepines for agitation, and administration of cyproheptadine (a serotonin antagonist) in severe cases.

Medications:
Cyproheptadine (antihistamine with serotonin antagonist properties), benzodiazepines for sedation, and IV fluids for stabilization.

Prevalence: How common the health condition is within a specific population.
Incidence is relatively rare but can occur in up to 15% of SSRI overdoses.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Polypharmacy involving serotonergic drugs, overdose, or genetic susceptibility to altered serotonin metabolism.

Prognosis: The expected outcome or course of the condition over time.
Good if treated promptly; untreated severe cases can lead to life-threatening complications like seizures or organ failure.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Seizures, rhabdomyolysis, renal failure, and cardiovascular collapse in severe cases.

Campylobacter Infections

Specialty: Infectious Diseases

Category: Bacterial Infections

Symptoms:
diarrhea; abdominal pain; fever; nausea; vomiting

Root Cause:
Caused by Campylobacter jejuni or Campylobacter coli, often through contaminated food or water, leading to gastrointestinal inflammation.

How it's Diagnosed: videos
Stool cultures, molecular assays, and antigen tests.

Treatment:
Supportive care for mild cases; antibiotics for severe cases or immunocompromised patients.

Medications:
Azithromycin (macrolide antibiotic) or ciprofloxacin (fluoroquinolone antibiotic).

Prevalence: How common the health condition is within a specific population.
One of the most common causes of bacterial diarrhea worldwide, with an estimated 96 million cases annually.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Consumption of undercooked poultry, unpasteurized milk, contaminated water, and international travel.

Prognosis: The expected outcome or course of the condition over time.
Usually self-limiting within a week; antibiotics hasten recovery in severe cases.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Guillain-Barré syndrome, reactive arthritis, and bloodstream infections.

CBRNE - Staphylococcal Enterotoxin B

Specialty: Infectious Diseases

Category: Bacterial Infections

Symptoms:
fever; chills; headache; nausea; vomiting; diarrhea; shortness of breath; potential septic shock

Root Cause:
Caused by exposure to Staphylococcus aureus enterotoxins, which act as superantigens triggering an exaggerated immune response.

How it's Diagnosed: videos
Clinical evaluation based on symptoms and potential exposure history. Laboratory confirmation by identifying enterotoxins in biological samples.

Treatment:
Supportive care (fluids, oxygen therapy). Antibiotics if secondary bacterial infection is suspected.

Medications:
Beta-lactam antibiotics such as cefazolin for secondary infections. Antipyretics like acetaminophen to reduce fever.

Prevalence: How common the health condition is within a specific population.
Rare; typically associated with bioterrorism events or foodborne outbreaks.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Occupational exposure, bioterrorism incidents, consumption of contaminated food.

Prognosis: The expected outcome or course of the condition over time.
Good with prompt supportive care; severe cases can result in complications or death if untreated.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Dehydration, respiratory failure, toxic shock syndrome.

Ehrlichiosis

Specialty: Infectious Diseases

Category: Bacterial Infections

Sub-category: Tick-Borne Diseases

Symptoms:
fever; headache; malaise; muscle aches; nausea; rash (less common)

Root Cause:
Infection by Ehrlichia species, transmitted by ticks, causing intracellular bacterial infection of white blood cells.

How it's Diagnosed: videos
Blood tests (PCR for Ehrlichia DNA, serology), complete blood count (CBC), and liver function tests.

Treatment:
Early initiation of antibiotic therapy and supportive care.

Medications:
Doxycycline (a tetracycline antibiotic) is the drug of choice.

Prevalence: How common the health condition is within a specific population.
Found primarily in areas with high tick populations, particularly in the southeastern and south-central United States.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Tick exposure, outdoor activities in endemic areas, and lack of tick precautions.

Prognosis: The expected outcome or course of the condition over time.
Excellent with prompt treatment; delays can lead to severe or fatal complications.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Respiratory distress syndrome, organ failure, and secondary infections.

Escherichia coli (E coli) Infections

Specialty: Infectious Diseases

Category: Bacterial Infections

Symptoms:
abdominal cramps; diarrhea (can be watery or bloody); nausea; vomiting; fever; fatigue

Root Cause:
Caused by specific strains of E. coli bacteria that produce toxins, leading to gastrointestinal or systemic infections.

How it's Diagnosed: videos
Stool culture, polymerase chain reaction (PCR) testing, and blood tests in severe cases to detect complications like hemolytic uremic syndrome (HUS).

Treatment:
Supportive care with hydration; antibiotics are used selectively, depending on the strain (e.g., avoid in Shiga toxin-producing E. coli). Severe cases may require hospitalization.

Medications:
Antibiotics such as ciprofloxacin (a fluoroquinolone) or TMP-SMX (a combination of trimethoprim and sulfamethoxazole ) for specific strains. Rehydration therapy with oral or IV solutions is critical.

Prevalence: How common the health condition is within a specific population.
Common cause of foodborne illness worldwide, affecting millions annually.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Consumption of undercooked meat, unpasteurized milk, contaminated water, or poor hand hygiene.

Prognosis: The expected outcome or course of the condition over time.
Generally resolves within a week for most cases. Complications like HUS can occur in 5–10% of Shiga toxin-producing E. coli infections, requiring intensive care.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Hemolytic uremic syndrome (HUS), kidney failure, dehydration, and sepsis in severe cases.

Helicobacter Pylori Infection

Specialty: Infectious Diseases

Category: Gastrointestinal Tract and Intra-abdominal Infections

Symptoms:
abdominal pain; nausea; vomiting; bloating; loss of appetite; unintentional weight loss; dark or tarry stools (indicating bleeding)

Root Cause:
Chronic infection caused by Helicobacter pylori bacteria, leading to inflammation of the stomach lining and increased risk of peptic ulcers and gastric cancer.

How it's Diagnosed: videos
Urea breath test, stool antigen test, blood test for antibodies, endoscopy with biopsy.

Treatment:
Combination of antibiotics to eradicate the bacteria and proton pump inhibitors (PPIs) to reduce stomach acid.

Medications:
Antibiotics (e.g., amoxicillin , clarithromycin , metronidazole ) to kill the bacteria. Proton pump inhibitors (PPIs, e.g., omeprazole , lansoprazole ) to reduce stomach acid and promote healing. Bismuth subsalicylate (part of quadruple therapy) to protect the stomach lining.

Prevalence: How common the health condition is within a specific population.
Affects approximately 50% of the global population; more common in developing countries due to poor sanitation.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Poor sanitation, contaminated food and water, close contact with an infected individual, family history of H. pylori infection.

Prognosis: The expected outcome or course of the condition over time.
Eradication is successful in most cases with appropriate therapy; untreated infections can lead to complications like ulcers or gastric cancer.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Peptic ulcers, gastric cancer, chronic gastritis, iron-deficiency anemia.

Listeria Monocytogenes Infection (Listeriosis)

Specialty: Infectious Diseases

Category: Bacterial Infections

Symptoms:
fever; muscle aches; nausea; diarrhea; stiff neck; confusion; loss of balance; convulsions

Root Cause:
Caused by the bacterium Listeria monocytogenes, typically through contaminated food. It invades host cells and can spread systemically, particularly affecting immunocompromised individuals.

How it's Diagnosed: videos
Blood cultures, cerebrospinal fluid (CSF) analysis, or stool cultures; polymerase chain reaction (PCR) testing for Listeria DNA.

Treatment:
Antibiotic therapy, supportive care for severe infections, and prevention through proper food handling.

Medications:
Ampicillin (penicillin-class antibiotic) is the first-line treatment; in cases of penicillin allergy, trimethoprim-sulfamethoxazole (sulfonamide-class antibiotic) can be used. For severe cases, combination therapy with gentamicin (aminoglycoside antibiotic) is recommended.

Prevalence: How common the health condition is within a specific population.
Rare, with approximately 0.1–10 cases per million people annually; more common in pregnant women, neonates, the elderly, and immunocompromised individuals.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Consuming contaminated food (e.g., unpasteurized dairy, processed meats), weakened immune system, pregnancy, newborn status.

Prognosis: The expected outcome or course of the condition over time.
Good with prompt treatment; however, untreated severe cases can lead to high mortality rates, especially in neonates and immunocompromised patients.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Meningitis, sepsis, miscarriage or stillbirth in pregnant women, encephalitis, and death in severe cases.

Meningococcemia

Specialty: Infectious Diseases

Category: Bacterial Infections

Sub-category: Systemic Infections

Symptoms:
fever; rash; cold extremities; rapid breathing; confusion; nausea; vomiting

Root Cause:
Caused by Neisseria meningitidis entering the bloodstream, leading to widespread vascular inflammation and potential sepsis.

How it's Diagnosed: videos
Blood cultures, CSF cultures, Gram stain, or PCR for Neisseria meningitidis DNA.

Treatment:
Immediate antibiotic therapy and supportive care, including fluid resuscitation and management of shock.

Medications:
Ceftriaxone or cefotaxime (cephalosporin-class antibiotics); penicillin G may also be used. Prophylaxis with rifampin (rifamycin-class antibiotic) or ciprofloxacin (fluoroquinolone-class antibiotic) for close contacts.

Prevalence: How common the health condition is within a specific population.
Sporadic and epidemic cases worldwide; incidence varies widely depending on region and vaccination rates.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Crowded living conditions, immune deficiencies, close contact with infected individuals.

Prognosis: The expected outcome or course of the condition over time.
Life-threatening without treatment; mortality can be reduced with prompt therapy, but survivors may face long-term complications.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Septic shock, disseminated intravascular coagulation (DIC), limb loss due to necrosis, neurological damage.

Relapsing Fever

Specialty: Infectious Diseases

Category: Bacterial Infections

Symptoms:
recurring episodes of high fever; chills; headaches; muscle and joint pain; nausea; vomiting; rash

Root Cause:
Caused by infection with Borrelia bacteria transmitted by lice (Louse-Borne Relapsing Fever) or soft-bodied ticks (Tick-Borne Relapsing Fever).

How it's Diagnosed: videos
Blood smear microscopy during febrile episodes, polymerase chain reaction (PCR) testing, or serological tests for Borrelia.

Treatment:
Antibiotics such as doxycycline or erythromycin; supportive care for symptoms like dehydration or electrolyte imbalance.

Medications:
Doxycycline (a tetracycline antibiotic), erythromycin (a macrolide antibiotic), or penicillin G (a beta-lactam antibiotic for severe cases).

Prevalence: How common the health condition is within a specific population.
Rare in developed countries; more common in resource-limited settings, especially in Africa.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Exposure to tick- or louse-infested areas, living in crowded or unsanitary conditions, and travel to endemic regions.

Prognosis: The expected outcome or course of the condition over time.
Good with timely treatment; symptoms resolve after antibiotic therapy, though Jarisch-Herxheimer reaction may occur shortly after treatment begins.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Jarisch-Herxheimer reaction, myocarditis, meningitis, multiorgan failure, or death if left untreated.

Rocky Mountain Spotted Fever (RMSF)

Specialty: Infectious Diseases

Category: Bacterial Infections

Sub-category: Rickettsial Diseases

Symptoms:
fever; headache; rash (starting on wrists and ankles); muscle aches; nausea; vomiting; confusion

Root Cause:
Caused by infection with Rickettsia rickettsii, transmitted by tick bites.

How it's Diagnosed: videos
Clinical presentation, serological testing, and PCR.

Treatment:
Immediate administration of doxycycline; treatment is started empirically based on suspicion.

Medications:
Doxycycline (tetracycline antibiotic); chloramphenicol (alternative for pregnant women in certain cases).

Prevalence: How common the health condition is within a specific population.
Endemic in the Americas, particularly in the southeastern United States.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Exposure to tick-infested areas, lack of protective clothing during outdoor activities.

Prognosis: The expected outcome or course of the condition over time.
Good with early treatment; delayed diagnosis can lead to severe complications or death.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Multi-organ failure, disseminated intravascular coagulation (DIC), or long-term neurological deficits.

Spontaneous Bacterial Peritonitis (SBP)

Specialty: Infectious Diseases

Category: Bacterial Infections

Symptoms:
fever; abdominal pain; nausea; vomiting; altered mental status; diarrhea; low blood pressure; tachycardia

Root Cause:
Infection of the peritoneal fluid in patients with cirrhosis and ascites, often due to bacterial translocation from the gut.

How it's Diagnosed: videos
Diagnostic paracentesis showing ascitic fluid with polymorphonuclear leukocytes (PMN) >250 cells/mm³, positive bacterial cultures, and low protein levels in ascitic fluid.

Treatment:
Antibiotics, supportive care, and management of the underlying cirrhosis or liver disease.

Medications:
Empiric therapy typically includes third-generation cephalosporins (e.g., cefotaxime or ceftriaxone ). Fluoroquinolones (e.g., ciprofloxacin ) may be used for prophylaxis in high-risk patients.

Prevalence: How common the health condition is within a specific population.
Affects 10-30% of patients with cirrhosis and ascites.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Advanced liver cirrhosis, low protein concentration in ascitic fluid, gastrointestinal bleeding, prior episodes of SBP.

Prognosis: The expected outcome or course of the condition over time.
With prompt treatment, the mortality rate can be reduced, but the recurrence rate is high without prophylaxis.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Sepsis, hepatic encephalopathy, acute kidney injury, death.

Bacterial Meningitis (Empiric Therapy)

Specialty: Infectious Diseases

Category: CNS Infections

Symptoms:
fever; neck stiffness; severe headache; nausea; vomiting; photophobia; altered mental status; seizures

Root Cause:
Acute inflammation of the meninges caused by bacterial infection.

How it's Diagnosed: videos
Clinical examination, lumbar puncture with cerebrospinal fluid (CSF) analysis (showing elevated white cell count, low glucose, and high protein), blood cultures, and imaging (CT or MRI if indicated).

Treatment:
Empiric antibiotic therapy (before the causative organism is identified), adjunctive corticosteroids, and supportive care.

Medications:
Empiric therapy often includes ceftriaxone or cefotaxime (3rd generation cephalosporins, broad-spectrum antibiotics), vancomycin (to cover resistant strains), and ampicillin (to cover Listeria monocytogenes in specific populations). Corticosteroids like dexamethasone are used to reduce inflammation.

Prevalence: How common the health condition is within a specific population.
Incidence varies by region and age group; approximately 2-5 cases per 100,000 people annually in developed countries.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Immunosuppression, head trauma, invasive procedures, close contact with infected individuals, crowded living conditions, and extremes of age (infants and elderly).

Prognosis: The expected outcome or course of the condition over time.
With prompt treatment, mortality is 5-30%, but delays in therapy significantly worsen outcomes. Neurological sequelae like hearing loss can occur.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Sepsis, increased intracranial pressure, stroke, seizures, and long-term neurological damage.

Bacterial Meningitis (Organism-Specific Therapy)

Specialty: Infectious Diseases

Category: CNS Infections

Symptoms:
fever; neck stiffness; severe headache; nausea; vomiting; photophobia; altered mental status; seizures

Root Cause:
Inflammation of the meninges caused by specific bacterial pathogens like Neisseria meningitidis, Streptococcus pneumoniae, or Listeria monocytogenes.

How it's Diagnosed: videos
Identification of causative organism through cerebrospinal fluid (CSF) culture or polymerase chain reaction (PCR), blood cultures, and gram staining.

Treatment:
Targeted antibiotic therapy based on organism and susceptibility, adjunctive corticosteroids in certain cases, and supportive measures.

Medications:
For Neisseria meningitidis - Ceftriaxone or cefotaxime (3rd generation cephalosporins). For Streptococcus pneumoniae - Vancomycin plus ceftriaxone or cefotaxime . For Listeria monocytogenes - Ampicillin or penicillin G, often combined with gentamicin . Corticosteroids (e.g., dexamethasone ) to reduce inflammatory response in specific cases.

Prevalence: How common the health condition is within a specific population.
Variable depending on region and vaccination coverage; more common in low-resource settings.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Age, immunodeficiency, lack of vaccination, recent head trauma or surgery, and close contact with infected individuals.

Prognosis: The expected outcome or course of the condition over time.
Depends on early identification and treatment; targeted therapy improves outcomes, but significant mortality and morbidity can occur in severe cases.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Neurological deficits, hearing loss, hydrocephalus, brain abscess, or death.

California Encephalitis

Specialty: Infectious Diseases

Category: CNS Infections

Symptoms:
fever; headache; nausea; vomiting; seizures; lethargy; meningeal irritation; neurological impairments in severe cases

Root Cause:
Viral infection caused by California serogroup viruses (e.g., La Crosse virus), primarily transmitted through mosquito bites.

How it's Diagnosed: videos
Clinical evaluation, lumbar puncture with cerebrospinal fluid (CSF) analysis, serologic or PCR testing for viral RNA.

Treatment:
Supportive care including antipyretics, anticonvulsants, and management of intracranial pressure.

Medications:
No specific antiviral therapy; symptomatic treatment includes antipyretics like acetaminophen and anticonvulsants like levetiracetam .

Prevalence: How common the health condition is within a specific population.
Rare; typically affects children and adolescents in endemic regions of the United States.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Exposure to mosquito bites, residence in or travel to endemic areas, outdoor activities during peak mosquito seasons.

Prognosis: The expected outcome or course of the condition over time.
Most cases resolve with supportive care, but severe cases may lead to neurological sequelae or death.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Seizures, cognitive impairment, behavioral changes, or chronic neurological deficits in severe cases.

Cysticercosis (Pork Tapeworm Infection)

Specialty: Infectious Diseases

Category: CNS Infections

Symptoms:
seizures; headaches; confusion; intracranial hypertension; vision changes; nausea; vomiting

Root Cause:
Infection with Taenia solium larvae, often acquired through ingestion of food or water contaminated with eggs of the pork tapeworm.

How it's Diagnosed: videos
MRI or CT scans to detect cysts in the brain, serologic tests (enzyme-linked immunoelectrotransfer blot), and patient history of exposure.

Treatment:
Combination of antiparasitic therapy, corticosteroids, and symptomatic treatment. Surgery may be required in some cases to remove cysts or relieve pressure.

Medications:
Antiparasitic medications include albendazole or praziquantel (antihelminthic drugs). Corticosteroids such as dexamethasone or prednisone are used to control inflammation. Antiepileptic drugs (e.g., phenytoin , carbamazepine ) are prescribed to manage seizures.

Prevalence: How common the health condition is within a specific population.
Endemic in developing countries, particularly in areas with poor sanitation and where pigs are raised. Prevalence varies widely but is common in parts of Latin America, Africa, and Asia.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Consumption of undercooked pork, poor sanitation, exposure to feces contaminated with Taenia solium eggs.

Prognosis: The expected outcome or course of the condition over time.
With prompt diagnosis and treatment, prognosis is generally good, although chronic neurological effects may persist in severe cases.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Hydrocephalus, chronic seizures, encephalitis, and death in severe untreated cases.

Haemophilus Meningitis

Specialty: Infectious Diseases

Category: CNS Infections

Symptoms:
fever; stiff neck; headache; nausea; vomiting; sensitivity to light; altered mental status; seizures

Root Cause:
Bacterial infection caused by Haemophilus influenzae type b (Hib), leading to inflammation of the meninges.

How it's Diagnosed: videos
Lumbar puncture for cerebrospinal fluid analysis, Gram staining, and culture; PCR tests for Hib DNA.

Treatment:
Intravenous antibiotics and supportive care.

Medications:
Third-generation cephalosporins like ceftriaxone or cefotaxime are the antibiotics of choice. Adjunctive dexamethasone may be used to reduce inflammation.

Prevalence: How common the health condition is within a specific population.
Rare in countries with widespread Hib vaccination; still occurs in unvaccinated populations or areas with low vaccine coverage.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Lack of vaccination, young age (children under 5), weakened immune system.

Prognosis: The expected outcome or course of the condition over time.
With prompt antibiotic treatment, prognosis is good, although complications such as hearing loss may occur.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Hearing loss, intellectual disability, seizures, and death if untreated.

Naegleria Infection and Primary Amebic Meningoencephalitis (PAM)

Specialty: Infectious Diseases

Category: CNS Infections

Symptoms:
severe headache; fever; nausea; vomiting; stiff neck; seizures; altered mental status; hallucinations; coma

Root Cause:
Infection caused by the amoeba Naegleria fowleri, which invades the brain through the nasal passages, often following freshwater exposure.

How it's Diagnosed: videos
Analysis of cerebrospinal fluid (CSF) through lumbar puncture, identification of Naegleria in CSF via microscopy, polymerase chain reaction (PCR), or antigen testing; brain imaging (MRI or CT) for inflammation.

Treatment:
Aggressive antimicrobial therapy including amphotericin B (intravenous and intrathecal), supportive care for cerebral edema, and experimental medications like miltefosine.

Medications:
Amphotericin B (antifungal), miltefosine (antiparasitic), rifampin (antibiotic), fluconazole (antifungal), and azithromycin (antibiotic). These medications aim to target the amoeba directly and reduce associated inflammation.

Prevalence: How common the health condition is within a specific population.
Rare; fewer than 150 cases reported in the United States over several decades. Occurs more frequently in warm climates with freshwater exposure.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Freshwater swimming or diving, particularly in warm lakes or hot springs; use of untreated water for nasal irrigation.

Prognosis: The expected outcome or course of the condition over time.
Poor, with a mortality rate exceeding 97%; early diagnosis and treatment are critical for the few known survivors.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Rapidly progressing brain inflammation, brain herniation, coma, and death.

Staphylococcal Meningitis

Specialty: Infectious Diseases

Category: CNS Infections

Symptoms:
fever; severe headache; neck stiffness; nausea; vomiting; altered mental status; seizures

Root Cause:
Infection of the meninges caused by Staphylococcus aureus or other staphylococcal species, often following surgery, trauma, or bacteremia.

How it's Diagnosed: videos
Lumbar puncture with CSF analysis; Gram staining and culture; blood cultures.

Treatment:
Intravenous antibiotics tailored to culture sensitivity.

Medications:
Empiric therapy often includes vancomycin (glycopeptide) combined with ceftriaxone or meropenem (carbapenem). Adjusted based on susceptibility.

Prevalence: How common the health condition is within a specific population.
Rare; higher in healthcare-associated settings.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Neurosurgery, trauma, immunosuppression, systemic staphylococcal infections.

Prognosis: The expected outcome or course of the condition over time.
Good with early treatment; poor in untreated or advanced cases.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Brain abscesses, hearing loss, neurological deficits, septic shock.

Subdural Empyema

Specialty: Infectious Diseases

Category: CNS Infections

Symptoms:
fever; severe headache; nausea; altered mental status; focal neurological deficits; seizures

Root Cause:
Collection of pus between the dura mater and arachnoid membrane, often caused by bacterial infection spreading from sinuses or middle ear.

How it's Diagnosed: videos
MRI with contrast; CT scan; blood cultures.

Treatment:
Surgical drainage combined with antibiotic therapy.

Medications:
Broad-spectrum antibiotics, such as vancomycin (glycopeptide) with ceftriaxone (cephalosporin) or metronidazole (nitroimidazole class) for anaerobic coverage.

Prevalence: How common the health condition is within a specific population.
Rare; more common in males and children with sinus infections.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Sinusitis, otitis media, skull trauma, neurosurgery.

Prognosis: The expected outcome or course of the condition over time.
Good with timely intervention; delayed treatment increases risk of mortality and morbidity.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Brain abscess, cerebral venous thrombosis, neurological deficits, sepsis.

Tuberculous Meningitis

Specialty: Infectious Diseases

Category: CNS Infections

Symptoms:
headache; fever; nausea; vomiting; stiff neck; altered mental status; seizures

Root Cause:
Infection of the meninges by Mycobacterium tuberculosis, leading to inflammation and increased intracranial pressure.

How it's Diagnosed: videos
Lumbar puncture with CSF analysis (increased protein, low glucose, and lymphocytic predominance), imaging (MRI or CT), and microbiological tests for M. tuberculosis.

Treatment:
Long-term combination antitubercular therapy (e.g., isoniazid, rifampin, pyrazinamide, ethambutol), corticosteroids to reduce inflammation, and supportive care.

Medications:
First-line antitubercular drugs (e.g., isoniazid , rifampin ); corticosteroids (e.g., dexamethasone ) to manage inflammation.

Prevalence: How common the health condition is within a specific population.
More common in areas with high TB burden; rare in developed countries.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
HIV infection, immunosuppression, close contact with TB patients, malnutrition.

Prognosis: The expected outcome or course of the condition over time.
With early treatment, survival is possible, but delayed therapy can result in high morbidity and mortality.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Hydrocephalus, stroke, cranial nerve palsies, cognitive deficits, and death if untreated.

Venezuelan Equine Encephalitis

Specialty: Infectious Diseases

Category: CNS Infections

Symptoms:
fever; headache; nausea; vomiting; seizures; confusion; weakness; photophobia

Root Cause:
Caused by the Venezuelan equine encephalitis virus, transmitted by mosquitoes, leading to inflammation of the brain.

How it's Diagnosed: videos
Serologic tests for viral antibodies (e.g., ELISA), PCR for viral RNA, and CSF analysis.

Treatment:
Supportive care (e.g., hydration, antipyretics, and seizure control); no specific antiviral treatment available.

Medications:
Antipyretics (e.g., acetaminophen for fever); anticonvulsants (e.g., phenytoin or valproic acid for seizures).

Prevalence: How common the health condition is within a specific population.
Sporadic outbreaks in Central and South America; rare in humans, more common in equines.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Living or working in endemic areas, exposure to mosquitoes, and outdoor activities.

Prognosis: The expected outcome or course of the condition over time.
Most recover fully, but severe cases may lead to neurological deficits or death.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Long-term neurological sequelae (e.g., cognitive deficits, epilepsy), and in severe cases, death.

Viral Encephalitis

Specialty: Infectious Diseases

Category: CNS Infections

Symptoms:
fever; headache; confusion; seizures; nausea; vomiting; altered mental status; photophobia

Root Cause:
Brain inflammation caused by viral infections (e.g., herpes simplex virus, arboviruses), leading to neuronal damage.

How it's Diagnosed: videos
Clinical evaluation, CSF analysis, PCR for viral DNA/RNA, and neuroimaging (e.g., MRI).

Treatment:
Antiviral therapy for specific viruses (e.g., acyclovir for herpes simplex virus); supportive care for other viral causes.

Medications:
Acyclovir (for herpes simplex); antipyretics (e.g., ibuprofen for fever); anticonvulsants (e.g., levetiracetam for seizures).

Prevalence: How common the health condition is within a specific population.
Varies; common in areas with high mosquito-borne virus activity or sporadic herpes outbreaks.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Immunosuppression, unvaccinated status, and mosquito exposure.

Prognosis: The expected outcome or course of the condition over time.
Depends on the cause and severity; early treatment improves outcomes, but severe cases may result in lasting deficits.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Long-term neurological damage, seizures, cognitive deficits, and death if untreated.

Viral Meningitis

Specialty: Infectious Diseases

Category: CNS Infections

Symptoms:
headache; fever; neck stiffness; photophobia; nausea; vomiting

Root Cause:
Inflammation of the meninges caused by viral infections (e.g., enteroviruses, herpesviruses), leading to non-purulent inflammation.

How it's Diagnosed: videos
CSF analysis (increased lymphocytes, normal glucose, elevated protein), PCR for viral pathogens.

Treatment:
Supportive care (hydration, pain relief, antipyretics); antiviral therapy for specific causes (e.g., herpesvirus).

Medications:
Acyclovir (for herpes-related cases); over-the-counter analgesics (e.g., acetaminophen for headache and fever).

Prevalence: How common the health condition is within a specific population.
Common; most cases are mild and self-limiting.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Exposure to infected individuals, immunosuppression, and travel to endemic regions.

Prognosis: The expected outcome or course of the condition over time.
Excellent in most cases; severe outcomes are rare.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Rare; may include chronic headaches or recurrent symptoms.

Western Equine Encephalitis (WEE)

Specialty: Infectious Diseases

Category: CNS Infections

Symptoms:
fever; headache; nausea; vomiting; seizures; altered mental status; muscle weakness

Root Cause:
Caused by the Western equine encephalitis virus, transmitted by mosquitoes, leading to inflammation of the brain and central nervous system.

How it's Diagnosed: videos
Serologic testing for viral antibodies (e.g., IgM ELISA), PCR for viral RNA, and CSF analysis.

Treatment:
Supportive care (e.g., intravenous fluids, fever control, seizure management); no specific antiviral therapy available.

Medications:
Antipyretics (e.g., ibuprofen for fever and discomfort); anticonvulsants (e.g., diazepam or levetiracetam for seizure control).

Prevalence: How common the health condition is within a specific population.
Rare; found in North and South America, with sporadic outbreaks in rural areas.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Exposure to mosquitoes in endemic regions, outdoor activities, and lack of mosquito control.

Prognosis: The expected outcome or course of the condition over time.
Most cases are mild and resolve without long-term effects; severe cases can lead to neurological deficits or death, particularly in children and the elderly.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Long-term neurological deficits (e.g., cognitive impairment, motor dysfunction), seizures, and death in severe cases.

Cryptococcosis

Specialty: Infectious Diseases

Category: Fungal Infections

Sub-category: Opportunistic Mycoses

Symptoms:
fever; headache; nausea; vomiting; altered mental status; neck stiffness in meningitis; cough; chest pain

Root Cause:
Infection by Cryptococcus neoformans or Cryptococcus gattii, typically through inhalation of spores, often affecting immunocompromised individuals.

How it's Diagnosed: videos
India ink staining, cryptococcal antigen testing, fungal cultures, or molecular diagnostics.

Treatment:
Induction therapy with amphotericin B and flucytosine, followed by maintenance therapy with fluconazole.

Medications:
Amphotericin B (polyenes), flucytosine (antifungal antimetabolite), and fluconazole (azole antifungal). These target fungal membranes or DNA synthesis.

Prevalence: How common the health condition is within a specific population.
Common opportunistic infection in HIV/AIDS patients, with significant global burden in low-resource settings.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
HIV/AIDS, organ transplantation, corticosteroid use, and other immunosuppressive conditions.

Prognosis: The expected outcome or course of the condition over time.
Early treatment significantly improves outcomes, though CNS involvement can lead to high mortality (up to 70% in severe untreated cases).

Complications: Additional problems or conditions that may arise as a result of the original condition.
Cryptococcal meningitis, hydrocephalus, vision loss, and neurological deficits.

Bacterial Gastroenteritis

Specialty: Infectious Diseases

Category: Gastrointestinal Tract and Intra-abdominal Infections

Symptoms:
diarrhea (often watery or bloody); abdominal cramps; fever; nausea; vomiting; dehydration

Root Cause:
Infection of the gastrointestinal tract caused by pathogenic bacteria like Salmonella, Shigella, Escherichia coli, or Campylobacter.

How it's Diagnosed: videos
Stool cultures, stool antigen tests, and molecular testing (PCR) to identify bacterial pathogens; clinical history of recent travel or food exposure.

Treatment:
Rehydration therapy (oral or intravenous), dietary adjustments, and in severe cases, antibiotics depending on the pathogen.

Medications:
Antibiotics like ciprofloxacin (fluoroquinolone) or azithromycin (macrolide) are used for severe infections. Oral rehydration solutions (ORS) and zinc supplementation help manage dehydration.

Prevalence: How common the health condition is within a specific population.
A common cause of morbidity worldwide, particularly in low-resource settings; affects millions annually, especially children under five.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Contaminated food or water, poor hygiene, travel to endemic areas, and immunocompromised states.

Prognosis: The expected outcome or course of the condition over time.
Usually self-limiting; severe cases may lead to complications without prompt treatment.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Severe dehydration, hemolytic uremic syndrome (HUS), and reactive arthritis.

Bacterial Overgrowth Syndrome

Specialty: Infectious Diseases

Category: Gastrointestinal Tract and Intra-abdominal Infections

Symptoms:
abdominal bloating; diarrhea; malabsorption; weight loss; fatigue; nausea

Root Cause:
Excessive growth of bacteria in the small intestine causing nutrient malabsorption and gastrointestinal symptoms.

How it's Diagnosed: videos
Breath tests (hydrogen or methane), small bowel aspirate and culture, and clinical response to treatment.

Treatment:
Addressing underlying causes, dietary modifications, and antibiotics to reduce bacterial load.

Medications:
Rifaximin (broad-spectrum non-absorbable antibiotic), metronidazole (antimicrobial), and probiotics to restore gut flora balance.

Prevalence: How common the health condition is within a specific population.
Exact prevalence is uncertain; common in conditions causing motility disorders or structural abnormalities of the GI tract.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Chronic gastrointestinal diseases (e.g., irritable bowel syndrome, Crohn’s disease), previous surgeries (e.g., gastric bypass), and use of proton pump inhibitors.

Prognosis: The expected outcome or course of the condition over time.
Good with appropriate treatment; symptoms often resolve but recurrence is possible.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Chronic malnutrition, vitamin deficiencies (B12, fat-soluble vitamins), and increased intestinal permeability.

Clostridioides (Clostridium) Difficile Colitis

Specialty: Infectious Diseases

Category: Gastrointestinal Tract and Intra-abdominal Infections

Symptoms:
watery diarrhea; abdominal pain; fever; nausea; loss of appetite; dehydration; foul-smelling stool

Root Cause:
Infection caused by Clostridioides difficile bacteria, leading to an overgrowth in the colon often triggered by antibiotic use that disrupts normal gut flora.

How it's Diagnosed: videos
Stool tests for C. difficile toxins or genetic material (PCR), colonoscopy to identify pseudomembranous colitis, and imaging (e.g., CT scan) in severe cases.

Treatment:
Discontinuation of the inciting antibiotic, initiation of specific antibiotics to target C. difficile, and, in severe cases, fecal microbiota transplantation (FMT).

Medications:
Vancomycin (oral, first-line treatment for severe cases, classified as glycopeptide antibiotics), Fidaxomicin (narrow-spectrum antibiotic targeting C. difficile), and Metronidazole (alternative treatment for mild to moderate cases, classified as a nitroimidazole antibiotic).

Prevalence: How common the health condition is within a specific population.
Affects about 500,000 people annually in the U.S.; more common in hospitalized or recently discharged patients.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Recent antibiotic use, advanced age, hospitalization, weakened immune system, gastrointestinal surgery, proton pump inhibitor use.

Prognosis: The expected outcome or course of the condition over time.
Good with appropriate treatment; however, recurrence occurs in approximately 20–25% of patients.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Severe dehydration, toxic megacolon, bowel perforation, sepsis, and death in extreme cases.

Cyclospora Infection (Cyclosporiasis)

Specialty: Infectious Diseases

Category: Gastrointestinal Tract and Intra-abdominal Infections

Symptoms:
watery diarrhea; loss of appetite; weight loss; cramping; bloating; gas; fatigue; nausea; low-grade fever

Root Cause:
Protozoan parasite Cyclospora cayetanensis infects the small intestine, often transmitted via contaminated food or water.

How it's Diagnosed: videos
Stool examination for Cyclospora oocysts, using microscopy with special stains or molecular techniques like PCR.

Treatment:
Antiparasitic therapy, rehydration, and electrolyte replacement.

Medications:
Trimethoprim-sulfamethoxazole (TMP-SMX, classified as a combination antibiotic) is the primary treatment. No alternative medications are well-established for sulfa-allergic patients.

Prevalence: How common the health condition is within a specific population.
Sporadic outbreaks in the U.S. often linked to imported fresh produce; endemic in tropical and subtropical regions.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Consumption of contaminated food or water, international travel, and weakened immune systems.

Prognosis: The expected outcome or course of the condition over time.
Excellent with treatment; without treatment, symptoms may persist for weeks.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Severe dehydration and malabsorption in prolonged or untreated cases.

Hepatitis A

Specialty: Infectious Diseases

Category: Liver Infections

Sub-category: Acute Viral Hepatitis

Symptoms:
fatigue; nausea; vomiting; abdominal pain; jaundice; dark urine; pale stools; fever

Root Cause:
Infection with the Hepatitis A virus (HAV) causing inflammation of the liver; spread primarily through contaminated food and water.

How it's Diagnosed: videos
Blood tests detecting HAV-specific IgM antibodies, liver function tests.

Treatment:
Primarily supportive care (rest, hydration, avoiding alcohol); no specific antiviral therapy.

Medications:
No antiviral medications; symptomatic relief with antipyretics (e.g., acetaminophen for fever) or antiemetics for nausea.

Prevalence: How common the health condition is within a specific population.
Common in areas with poor sanitation; estimated 1.4 million cases worldwide annually.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Travel to endemic regions, consuming contaminated food or water, close contact with an infected person.

Prognosis: The expected outcome or course of the condition over time.
Full recovery in most cases within weeks to months; no chronic infection.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Rare, but can include fulminant hepatitis in older adults or those with pre-existing liver conditions.

Hepatitis B

Specialty: Infectious Diseases

Category: Liver Infections

Sub-category: Chronic Viral Hepatitis

Symptoms:
fatigue; loss of appetite; nausea; jaundice; dark urine; joint pain; abdominal pain

Root Cause:
Infection with the Hepatitis B virus (HBV), which can cause both acute and chronic liver inflammation, leading to liver damage.

How it's Diagnosed: videos
Blood tests for HBsAg (surface antigen), anti-HBc antibodies, and HBV DNA; liver function tests.

Treatment:
Treated with antiviral medications such as tenofovir or entecavir to suppress viral replication, alongside interferon therapy in select cases, and supportive care, with monitoring for liver function and complications.

Medications:
Nucleos(t)ide analogs (e.g., entecavir , tenofovir ) to inhibit viral replication. Interferon-alpha injections to boost the immune response.

Prevalence: How common the health condition is within a specific population.
Affects over 296 million people worldwide; common in Asia and Africa.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Unprotected sex, needle-sharing, perinatal transmission, healthcare worker exposure.

Prognosis: The expected outcome or course of the condition over time.
Acute cases often resolve; chronic cases may progress to cirrhosis or liver cancer without treatment.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Liver cirrhosis, hepatocellular carcinoma, liver failure.

Hepatitis C

Specialty: Infectious Diseases

Category: Liver Infections

Sub-category: Chronic Viral Hepatitis

Symptoms:
fatigue; nausea; loss of appetite; jaundice; dark urine; joint pain; abdominal pain

Root Cause:
Infection with the Hepatitis C virus (HCV), often leading to chronic liver inflammation and scarring.

How it's Diagnosed: videos
Blood tests for anti-HCV antibodies and HCV RNA, liver function tests.

Treatment:
Direct-acting antivirals (DAAs) to cure the infection.

Medications:
DAAs (e.g., sofosbuvir , ledipasvir , velpatasvir ) targeting viral proteins for replication. Ribavirin (in combination in certain cases).

Prevalence: How common the health condition is within a specific population.
Affects over 58 million people worldwide; common in intravenous drug users.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Needle-sharing, blood transfusions (before 1992), healthcare exposure, tattoos or piercings with unsterilized equipment.

Prognosis: The expected outcome or course of the condition over time.
Highly curable with DAAs in 8–12 weeks; untreated, it may progress to cirrhosis or liver cancer.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Liver cirrhosis, hepatocellular carcinoma, portal hypertension.

Hepatitis D

Specialty: Infectious Diseases

Category: Liver Infections

Sub-category: Chronic Viral Hepatitis

Symptoms:
fatigue; nausea; jaundice; dark urine; abdominal pain; joint pain

Root Cause:
Co-infection or superinfection with the Hepatitis D virus (HDV) in individuals already infected with Hepatitis B. HDV requires HBV to replicate.

How it's Diagnosed: videos
Blood tests for anti-HDV antibodies and HDV RNA, liver function tests.

Treatment:
Pegylated interferon-alpha; no specific antiviral therapy.

Medications:
Pegylated interferon-alpha to suppress viral replication; supportive care.

Prevalence: How common the health condition is within a specific population.
Estimated 5–10% of individuals with HBV are co-infected with HDV.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Same as Hepatitis B, especially intravenous drug use and unprotected sex.

Prognosis: The expected outcome or course of the condition over time.
Worse than HBV alone; higher risk of progression to cirrhosis and liver cancer.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Liver cirrhosis, hepatocellular carcinoma, liver failure.

Hepatitis E

Specialty: Infectious Diseases

Category: Liver Infections

Sub-category: Acute Viral Hepatitis

Symptoms:
fatigue; nausea; jaundice; dark urine; pale stools; abdominal pain; fever

Root Cause:
Infection with the Hepatitis E virus (HEV), often spread through contaminated water, leading to acute liver inflammation.

How it's Diagnosed: videos
Blood tests for anti-HEV antibodies (IgM), HEV RNA in serum or stool.

Treatment:
Supportive care; ribavirin in severe or chronic cases (e.g., immunocompromised patients).

Medications:
Ribavirin (antiviral, used selectively for chronic cases).

Prevalence: How common the health condition is within a specific population.
Affects over 20 million people annually, primarily in developing regions.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Contaminated water, poor sanitation, undercooked pork or wild game meat.

Prognosis: The expected outcome or course of the condition over time.
Full recovery in most cases; higher mortality in pregnant women.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Acute liver failure, particularly in pregnant women or immunocompromised individuals.

Pancreatic Necrosis and Pancreatic Abscess

Specialty: Infectious Diseases

Category: Gastrointestinal Tract and Intra-abdominal Infections

Symptoms:
severe abdominal pain; fever; nausea; vomiting; abdominal tenderness; tachycardia; jaundice in severe cases

Root Cause:
Pancreatic necrosis involves the death of pancreatic tissue due to severe inflammation or infection, often following acute pancreatitis. Pancreatic abscess is a collection of pus resulting from infected necrotic tissue or fluid accumulation.

How it's Diagnosed: videos
Diagnosed through clinical evaluation, imaging studies (CT scan or MRI), and blood tests including elevated white blood cell count, CRP, and amylase/lipase levels. Fine-needle aspiration (FNA) may confirm infection.

Treatment:
Treatment includes supportive care, drainage of abscesses, and, in severe cases, surgical debridement or necrosectomy. Antibiotics are used to manage infections.

Medications:
Antibiotics such as carbapenems (e.g., meropenem ), third-generation cephalosporins (e.g., ceftriaxone ), or fluoroquinolones (e.g., ciprofloxacin ) combined with metronidazole to cover anaerobes. These are classified as broad-spectrum antibiotics. Pain management includes opioids like morphine or hydromorphone .

Prevalence: How common the health condition is within a specific population.
Rare but occurs in 10-20% of cases of severe acute pancreatitis.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Alcohol abuse, gallstones, hyperlipidemia, pancreatic trauma, and delayed or inadequate treatment of acute pancreatitis.

Prognosis: The expected outcome or course of the condition over time.
Prognosis depends on early diagnosis and treatment. Mortality rates can reach 30-50% in cases of infected necrosis or untreated abscesses.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Sepsis, multiorgan failure, hemorrhage, diabetes mellitus, and chronic pancreatitis.

Salmonella Infection (Salmonellosis)

Specialty: Infectious Diseases

Category: Gastrointestinal Tract and Intra-abdominal Infections

Symptoms:
diarrhea; fever; abdominal cramps; nausea; vomiting; headache

Root Cause:
Infection by Salmonella bacteria, typically via contaminated food, water, or contact with infected animals.

How it's Diagnosed: videos
Stool culture, blood culture in severe cases, and molecular testing (PCR) to identify Salmonella species.

Treatment:
Supportive care with fluids and electrolytes; antibiotics (only for severe cases).

Medications:
Antibiotics like ciprofloxacin , azithromycin , or ceftriaxone for severe or systemic infections. These are classified as fluoroquinolones, macrolides, and third-generation cephalosporins, respectively.

Prevalence: How common the health condition is within a specific population.
Common worldwide; significant in developing regions due to poor sanitation.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Consumption of contaminated food, immunosuppression, and travel to endemic regions.

Prognosis: The expected outcome or course of the condition over time.
Self-limited in most cases; good with appropriate treatment for severe cases.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Dehydration, bacteremia, reactive arthritis, and localized infections (e.g., osteomyelitis).

Small Intestinal Diverticulosis

Specialty: Infectious Diseases

Category: Gastrointestinal Tract and Intra-abdominal Infections

Symptoms:
abdominal discomfort; bloating; nausea; vomiting; diarrhea or constipation; occult gastrointestinal bleeding in some cases

Root Cause:
Formation of diverticula (small pouches) in the small intestine, often due to increased intraluminal pressure or connective tissue weakness.

How it's Diagnosed: videos
Radiographic imaging (CT scan, small bowel follow-through, or capsule endoscopy) and incidental findings during evaluations for other conditions.

Treatment:
Mostly asymptomatic; dietary modifications and antibiotics for diverticulitis. Surgery in cases of complications like perforation.

Medications:
Antibiotics such as ciprofloxacin and metronidazole for diverticulitis. Prokinetics may be used for motility issues.

Prevalence: How common the health condition is within a specific population.
Rare; increases with age.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Older age, connective tissue disorders, and motility disorders.

Prognosis: The expected outcome or course of the condition over time.
Good in asymptomatic cases; complications may worsen outcomes.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Diverticulitis, perforation, fistula, and small bowel obstruction.

Viral Gastroenteritis

Specialty: Infectious Diseases

Category: Gastrointestinal Tract and Intra-abdominal Infections

Symptoms:
watery diarrhea; nausea; vomiting; fever; abdominal cramps; dehydration

Root Cause:
Inflammation of the stomach and intestines caused by viral infections (e.g., norovirus, rotavirus, adenovirus).

How it's Diagnosed: videos
Clinical diagnosis based on symptoms; stool PCR or antigen tests in specific cases.

Treatment:
Supportive care, including rehydration and electrolyte replacement. Antiemetics may be used for severe nausea.

Medications:
No specific antiviral treatment; oral rehydration solutions (ORS) and antiemetics like ondansetron may be used.

Prevalence: How common the health condition is within a specific population.
Very common worldwide, especially in children and in areas with poor sanitation.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Close contact with infected individuals, contaminated food or water, poor hand hygiene.

Prognosis: The expected outcome or course of the condition over time.
Excellent in most cases with supportive care; severe dehydration can be life-threatening without treatment.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Dehydration, electrolyte imbalances, and in rare cases, kidney injury.

Yellow Fever

Specialty: Infectious Diseases

Category: Gastrointestinal Tract and Intra-abdominal Infections

Symptoms:
fever; headache; muscle pain; nausea; vomiting; jaundice; abdominal pain; bleeding (e.g., from the gums or nose); organ failure in severe cases

Root Cause:
Yellow fever is caused by the yellow fever virus, a flavivirus transmitted by infected mosquitoes (primarily Aedes aegypti). It leads to systemic infection, liver damage, and subsequent jaundice and bleeding tendencies in severe cases.

How it's Diagnosed: videos
Diagnosed through serologic tests or PCR.

Treatment:
Treated supportively, as no specific antiviral therapy exists, with vaccination as a key preventive measure.

Medications:
No antiviral medications are available for yellow fever. Supportive medications include antipyretics like acetaminophen (avoid NSAIDs like ibuprofen or aspirin to reduce bleeding risks) and intravenous fluids for dehydration. Hemostatic agents may be used in cases of severe bleeding.

Prevalence: How common the health condition is within a specific population.
Yellow fever is endemic in tropical areas of Africa and South America. Annually, it causes an estimated 200,000 cases and 30,000 deaths globally, with most cases unreported.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Traveling to or living in endemic areas, lack of vaccination, and exposure to mosquito bites.

Prognosis: The expected outcome or course of the condition over time.
In mild cases, recovery occurs within days to weeks without long-term effects. Severe cases with complications like liver failure or bleeding have a mortality rate of 20–50%. Survivors of severe cases typically recover fully but may require prolonged convalescence.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Hepatic failure, renal failure, shock, disseminated intravascular coagulation (DIC), multi-organ failure, and death in severe cases.

Pyonephrosis

Specialty: Infectious Diseases

Category: Genitourinary Tract Infections

Symptoms:
fever; flank pain; chills; nausea; vomiting; cloudy or foul-smelling urine

Root Cause:
Accumulation of pus in the renal collecting system, often caused by an obstructive uropathy combined with infection.

How it's Diagnosed: videos
Ultrasound or CT imaging to detect hydronephrosis with echogenic debris; urine culture to identify infection; blood tests to check for systemic infection.

Treatment:
Drainage of pus through percutaneous nephrostomy or surgery; broad-spectrum antibiotics followed by culture-guided antibiotics.

Medications:
Broad-spectrum antibiotics such as piperacillin-tazobactam (beta-lactam/beta-lactamase inhibitor), carbapenems (e.g., meropenem ), or fluoroquinolones (e.g., ciprofloxacin ).

Prevalence: How common the health condition is within a specific population.
Rare; more common in patients with urinary obstruction or immunocompromised states.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Kidney stones, urinary tract obstruction, diabetes, immunosuppression, prior urinary infections.

Prognosis: The expected outcome or course of the condition over time.
Good with timely drainage and appropriate antibiotics; untreated cases can lead to sepsis and renal failure.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Sepsis, renal abscess, permanent kidney damage, or renal failure.

CNS Cryptococcosis in HIV

Specialty: Infectious Diseases

Category: Central Nervous System Complications in HIV

Symptoms:
headache; fever; nausea; vomiting; stiff neck; photophobia; altered mental status

Root Cause:
Opportunistic fungal infection caused by Cryptococcus neoformans or Cryptococcus gattii in immunocompromised individuals.

How it's Diagnosed: videos
CSF analysis with India ink staining, cryptococcal antigen test, fungal culture, and MRI/CT imaging for associated findings.

Treatment:
Initial treatment with amphotericin B and flucytosine for induction therapy, followed by fluconazole for consolidation and maintenance therapy; concurrent ART for HIV management.

Medications:
Amphotericin B (antifungal polyene), flucytosine (antifungal antimetabolite), fluconazole (azole antifungal).

Prevalence: How common the health condition is within a specific population.
Common in HIV patients with CD4 counts <100 cells/mm³, particularly in resource-limited settings.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Advanced HIV, environmental exposure to cryptococcal spores, lack of ART adherence.

Prognosis: The expected outcome or course of the condition over time.
High mortality if untreated; with prompt therapy, survival rates improve, though neurological sequelae may persist.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Increased intracranial pressure, hydrocephalus, and long-term cognitive deficits.

Legionnaires' Disease

Specialty: Infectious Diseases

Category: Lower Respiratory Tract Infections

Symptoms:
high fever; chills; cough (productive or dry); shortness of breath; muscle aches; headache; diarrhea; nausea; confusion or mental changes in severe cases

Root Cause:
Caused by infection with Legionella bacteria, commonly Legionella pneumophila. Infection occurs through inhalation of aerosolized water droplets contaminated with the bacteria.

How it's Diagnosed: videos
Diagnosis involves chest X-rays to detect pneumonia, urine antigen tests for Legionella species, sputum culture, and PCR tests. Blood tests may show abnormalities indicating infection.

Treatment:
Treated primarily with antibiotics that target Legionella, supportive care for symptoms such as oxygen therapy for breathing difficulties, and hydration for fluid balance.

Medications:
Antibiotics - Fluoroquinolones (e.g., levofloxacin , ciprofloxacin ), macrolides (e.g., azithromycin ), or tetracyclines (e.g., doxycycline ) are commonly prescribed. These are bactericidal or bacteriostatic medications effective against Legionella.

Prevalence: How common the health condition is within a specific population.
Infrequent but can occur sporadically or in outbreaks, especially in settings with poorly maintained water systems. Affects approximately 1-2 cases per 100,000 people annually in the U.S.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Age over 50, smoking, chronic lung disease, weakened immune system, history of recent travel (hotels or cruise ships with poor water system maintenance).

Prognosis: The expected outcome or course of the condition over time.
Early treatment with antibiotics results in recovery in most cases; however, severe cases, particularly in immunocompromised individuals, may lead to complications and higher mortality rates (10-15%).

Complications: Additional problems or conditions that may arise as a result of the original condition.
Respiratory failure, septic shock, multi-organ failure, long-term lung scarring, and secondary bacterial infections.

Middle East Respiratory Syndrome (MERS)

Specialty: Infectious Diseases

Category: Lower Respiratory Tract Infections

Symptoms:
fever; cough; shortness of breath; muscle pain; nausea; vomiting; diarrhea; abdominal pain

Root Cause:
Caused by the MERS-CoV coronavirus, transmitted through respiratory droplets or contact with infected individuals or camels. Severe cases involve acute respiratory distress syndrome (ARDS).

How it's Diagnosed: videos
Diagnosis is based on PCR testing for MERS-CoV in respiratory samples, chest imaging to detect pneumonia or ARDS, and serologic tests.

Treatment:
Supportive care, including oxygen therapy, mechanical ventilation in severe cases, and treatment of secondary infections. No specific antiviral therapy is widely accepted.

Medications:
Experimental - Antivirals (e.g., ribavirin ) combined with interferon have been investigated but are not standard treatments. Supportive medications - Antipyretics for fever, and bronchodilators for respiratory relief.

Prevalence: How common the health condition is within a specific population.
Outbreaks have primarily occurred in the Middle East. Limited cases in other regions due to travel-associated spread. Mortality rates range from 30-40%.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Close contact with camels, healthcare exposure to infected individuals, age over 50, pre-existing chronic diseases (e.g., diabetes, heart disease).

Prognosis: The expected outcome or course of the condition over time.
Severe cases can progress to multi-organ failure and death, particularly in high-risk groups. Mild cases may resolve with symptomatic management.

Complications: Additional problems or conditions that may arise as a result of the original condition.
ARDS, septic shock, renal failure, and long-term pulmonary complications in survivors.

Psittacosis (Parrot Fever)

Specialty: Infectious Diseases

Category: Lower Respiratory Tract Infections

Symptoms:
fever; chills; headache; dry cough; muscle aches; shortness of breath; nausea; vomiting; fatigue

Root Cause:
Zoonotic infection caused by Chlamydia psittaci, typically transmitted through inhalation of dried droppings, secretions, or dust from infected birds.

How it's Diagnosed: videos
Diagnosis involves serologic testing for C. psittaci antibodies, PCR testing, and chest imaging to confirm pneumonia.

Treatment:
Antibiotic therapy is the primary treatment, often combined with supportive care for symptom relief.

Medications:
Antibiotics - Tetracyclines (e.g., doxycycline ) are the treatment of choice. Macrolides (e.g., azithromycin ) may be used as an alternative.

Prevalence: How common the health condition is within a specific population.
Rare, primarily affecting individuals in close contact with birds, such as pet owners, veterinarians, and bird handlers.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Exposure to infected birds, handling bird droppings, or working in environments with birds.

Prognosis: The expected outcome or course of the condition over time.
Good with appropriate treatment; most patients recover fully. Untreated cases can lead to severe complications.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Endocarditis, myocarditis, respiratory failure, and multi-organ dysfunction in severe cases.

Alveolar Echinococcosis (AE)

Specialty: Infectious Diseases

Category: Parasitic Infections

Symptoms:
abdominal pain; weight loss; jaundice; liver enlargement; nausea; weakness

Root Cause:
Caused by the larval stage of Echinococcus multilocularis, which forms invasive cysts, primarily in the liver.

How it's Diagnosed: videos
Imaging studies (ultrasound, CT, MRI), serological testing for Echinococcus antibodies, and biopsy for definitive diagnosis.

Treatment:
Surgical removal of the lesion when possible, long-term antiparasitic therapy.

Medications:
Albendazole (anthelmintic) is the primary medication; mebendazole is an alternative.

Prevalence: How common the health condition is within a specific population.
Rare, primarily found in the northern hemisphere, including parts of Europe, Asia, and North America.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Contact with infected animals (e.g., dogs, foxes), consuming contaminated food or water, and living in endemic regions.

Prognosis: The expected outcome or course of the condition over time.
Good with early detection and treatment; untreated cases have a poor prognosis due to invasive growth.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Liver failure, metastasis to other organs, secondary infections.

Ascariasis

Specialty: Infectious Diseases

Category: Parasitic Infections

Symptoms:
abdominal pain; nausea; vomiting; malnutrition; intestinal blockage; cough (during larval migration)

Root Cause:
Infection with Ascaris lumbricoides, a roundworm transmitted through ingestion of eggs from contaminated soil or food.

How it's Diagnosed: videos
Stool analysis for eggs, imaging studies for intestinal obstruction, and sometimes ultrasound or CT for heavy infections.

Treatment:
Anthelmintic medications, sometimes surgery for complications.

Medications:
Albendazole or mebendazole are commonly prescribed; pyrantel pamoate is an alternative.

Prevalence: How common the health condition is within a specific population.
Highly prevalent in tropical and subtropical regions, especially in areas with poor sanitation.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Contaminated soil or water, poor hygiene, and living in endemic areas.

Prognosis: The expected outcome or course of the condition over time.
Excellent with treatment; severe cases with complications may require additional interventions.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Intestinal obstruction, malnutrition, growth retardation in children, and migration of worms to other organs.

Balantidiasis

Specialty: Infectious Diseases

Category: Parasitic Infections

Symptoms:
diarrhea; abdominal pain; nausea; vomiting; fever; weight loss

Root Cause:
Infection with Balantidium coli, a ciliate protozoan, typically acquired from contaminated food or water.

How it's Diagnosed: videos
Stool examination for trophozoites or cysts; rarely, colonoscopy and biopsy.

Treatment:
Antiprotozoal therapy.

Medications:
Tetracycline is the first-line treatment; metronidazole or iodoquinol are alternatives.

Prevalence: How common the health condition is within a specific population.
Rare, typically found in areas with poor sanitation and exposure to swine.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Close contact with pigs, contaminated water, and poor hygiene.

Prognosis: The expected outcome or course of the condition over time.
Good with treatment; untreated severe cases may lead to complications.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Perforation of the colon, peritonitis.

Cryptosporidiosis

Specialty: Infectious Diseases

Category: Parasitic Infections

Symptoms:
watery diarrhea; abdominal pain; nausea; vomiting; fever; weight loss; dehydration

Root Cause:
Infection with Cryptosporidium species, primarily transmitted through ingestion of contaminated water or food.

How it's Diagnosed: videos
Stool analysis using acid-fast staining, direct fluorescent antibody tests, or PCR for Cryptosporidium DNA.

Treatment:
Supportive care to prevent dehydration; specific antiparasitic therapy for immunocompromised individuals.

Medications:
Nitazoxanide (antiprotozoal) is the primary treatment. Antidiarrheal agents may be used for symptom control.

Prevalence: How common the health condition is within a specific population.
Common worldwide, especially in children and immunocompromised individuals in low-resource settings.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Contaminated water sources, poor sanitation, immunosuppression (e.g., HIV/AIDS).

Prognosis: The expected outcome or course of the condition over time.
Good for immunocompetent individuals; chronic or severe disease in immunosuppressed patients.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Severe dehydration, malnutrition, and chronic diarrhea in immunocompromised individuals.

Cystoisosporiasis

Specialty: Infectious Diseases

Category: Parasitic Infections

Symptoms:
watery diarrhea; abdominal pain; cramping; nausea; vomiting; weight loss; fever

Root Cause:
Infection with Cystoisospora belli (formerly known as Isospora belli), a parasitic protozoan that invades the epithelial cells of the small intestine.

How it's Diagnosed: videos
Microscopic examination of stool samples to detect oocysts; acid-fast staining or molecular tests (e.g., PCR) may be used.

Treatment:
Primarily with antiparasitic medication and supportive care (rehydration and nutritional support).

Medications:
Trimethoprim-sulfamethoxazole (antibiotic combination, also known as Bactrim ) is the first-line treatment. For sulfa-allergic patients, pyrimethamine with leucovorin (folic acid) may be used.

Prevalence: How common the health condition is within a specific population.
Rare in developed countries; more common in tropical and subtropical regions and in immunocompromised individuals (e.g., HIV/AIDS).

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Immunosuppression, travel to or residence in endemic areas, poor sanitation, consumption of contaminated food or water.

Prognosis: The expected outcome or course of the condition over time.
Good with prompt treatment; chronic or recurrent infections may occur in immunocompromised patients.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Chronic diarrhea, malabsorption, dehydration, and significant weight loss, especially in immunocompromised individuals.

Diphyllobothriasis

Specialty: Infectious Diseases

Category: Parasitic Infections

Symptoms:
abdominal discomfort; nausea; diarrhea or constipation; weakness; weight loss; vitamin b12 deficiency symptoms like anemia or numbness

Root Cause:
Infection with the fish tapeworm (Diphyllobothrium latum), acquired through ingestion of raw or undercooked freshwater fish containing larvae.

How it's Diagnosed: videos
Identification of eggs or segments (proglottids) in stool samples; PCR may be used for species confirmation.

Treatment:
Anthelmintic medications and nutritional supplementation for vitamin B12 deficiency if present.

Medications:
Praziquantel (anthelmintic) is the drug of choice. Niclosamide can also be used as an alternative.

Prevalence: How common the health condition is within a specific population.
Common in regions where raw or undercooked fish is consumed, such as Scandinavia, Russia, and parts of Japan, Peru, and North America.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Eating raw or undercooked freshwater fish, poor food preparation practices, or living in endemic areas.

Prognosis: The expected outcome or course of the condition over time.
Excellent with treatment; complications are rare.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Severe vitamin B12 deficiency leading to megaloblastic anemia, neurological symptoms, and intestinal obstruction in rare cases.

Echinococcosis (Hydatid Cyst)

Specialty: Infectious Diseases

Category: Parasitic Infections

Symptoms:
abdominal pain; nausea; vomiting; cyst-related pressure effects; allergic reactions if the cyst ruptures

Root Cause:
Infection with Echinococcus granulosus or Echinococcus multilocularis, causing cystic or alveolar echinococcosis, respectively.

How it's Diagnosed: videos
Imaging studies (ultrasound, CT, or MRI), serological tests (ELISA, Western blot), and histopathological examination.

Treatment:
Surgical removal of cysts, percutaneous aspiration (PAIR technique), or antiparasitic drug therapy for inoperable cases.

Medications:
Albendazole and mebendazole (anthelmintics) are used to reduce cyst size or as adjuncts to surgery.

Prevalence: How common the health condition is within a specific population.
Endemic in sheep-raising regions such as the Middle East, Central Asia, South America, and parts of Africa.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Contact with infected dogs, livestock farming, poor hygiene practices.

Prognosis: The expected outcome or course of the condition over time.
Variable; excellent with early intervention, but alveolar echinococcosis can be life-threatening if untreated.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Cyst rupture leading to anaphylaxis, secondary bacterial infections, or dissemination of the infection.

Hookworm Disease

Specialty: Infectious Diseases

Category: Parasitic Infections

Symptoms:
iron deficiency anemia; fatigue; abdominal pain; diarrhea; nausea; itching and rash at the site of skin penetration (ground itch)

Root Cause:
Infection with hookworms such as Ancylostoma duodenale or Necator americanus, which attach to the intestinal lining and feed on blood.

How it's Diagnosed: videos
Stool examination for eggs or larvae; molecular methods may confirm the species.

Treatment:
Anthelmintic medications and iron supplementation for anemia.

Medications:
Albendazole or mebendazole (anthelmintics) are the drugs of choice. Pyrantel pamoate can be used as an alternative.

Prevalence: How common the health condition is within a specific population.
Common in tropical and subtropical regions with poor sanitation.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Walking barefoot on contaminated soil, poor sanitation, and inadequate access to clean water.

Prognosis: The expected outcome or course of the condition over time.
Good with treatment; untreated infections may lead to severe anemia and developmental delays in children.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Chronic anemia, malnutrition, and growth retardation in children.

Intestinal Flukes

Specialty: Infectious Diseases

Category: Parasitic Infections

Symptoms:
abdominal pain; diarrhea; nausea; malabsorption; weakness

Root Cause:
Infection with trematodes such as Fasciolopsis buski, acquired through ingestion of raw or undercooked aquatic plants contaminated with metacercariae.

How it's Diagnosed: videos
Stool examination for eggs; imaging or serological tests may assist in diagnosis.

Treatment:
Anthelmintic medications and supportive care for symptoms.

Medications:
Praziquantel (anthelmintic) is the treatment of choice. Nitazoxanide may be considered in some cases.

Prevalence: How common the health condition is within a specific population.
Common in parts of Southeast Asia and India where aquatic plants are consumed.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Consumption of contaminated water plants (e.g., water chestnuts), poor sanitation, and exposure to infected water sources.

Prognosis: The expected outcome or course of the condition over time.
Good with appropriate treatment; complications are rare.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Chronic malabsorption and malnutrition if untreated.

Malaria

Specialty: Infectious Diseases

Category: Parasitic Infections

Symptoms:
fever; chills; headache; nausea; vomiting; muscle pain; anemia; sweating; enlarged spleen

Root Cause:
Infection by Plasmodium parasites (e.g., P. falciparum, P. vivax) transmitted by infected Anopheles mosquitoes.

How it's Diagnosed: videos
Microscopy (blood smears), rapid diagnostic tests (RDTs), and polymerase chain reaction (PCR).

Treatment:
Antimalarial medications, supportive care for complications (e.g., blood transfusions for severe anemia).

Medications:
Artemisinin-based combination therapies (ACTs, e.g., artemether-lumefantrine), chloroquine (for chloroquine-sensitive strains), primaquine (for liver-stage hypnozoites), atovaquone-proguanil, and quinine .

Prevalence: How common the health condition is within a specific population.
Affects 240 million people annually, with the highest burden in sub-Saharan Africa.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Living in endemic areas, lack of insecticide-treated bed nets, poverty, and pregnancy.

Prognosis: The expected outcome or course of the condition over time.
Treatable, but severe malaria can cause death if untreated, especially in children and pregnant women.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Cerebral malaria, severe anemia, organ failure, and hypoglycemia.

Malaria Organism-Specific Therapy

Specialty: Infectious Diseases

Category: Parasitic Infections

Symptoms:
fever; chills; sweating; headache; nausea; vomiting; muscle aches; anemia

Root Cause:
Infection caused by specific Plasmodium species (P. falciparum, P. vivax, P. ovale, P. malariae, or P. knowlesi). Treatment tailored to the infecting species, drug resistance, and location.

How it's Diagnosed: videos
Microscopy, species-specific rapid diagnostic tests (RDTs), and PCR.

Treatment:
Therapy varies by species; includes addressing blood-stage parasites and dormant liver stages (P. vivax and P. ovale).

Medications:
P. falciparum - Artemisinin-based combination therapies (ACTs, e.g., artemether-lumefantrine). P. vivax - Chloroquine or ACTs for blood-stage; primaquine or tafenoquine for liver-stage hypnozoites. P. malariae and P. ovale - Similar to P. vivax protocols. P. knowlesi - Treated with ACTs or chloroquine .

Prevalence: How common the health condition is within a specific population.
Regional variations; P. falciparum most common in Africa, P. vivax predominant outside sub-Saharan Africa.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Traveling or living in endemic areas, lack of preventive measures (e.g., bed nets, prophylaxis).

Prognosis: The expected outcome or course of the condition over time.
Effective treatment reduces mortality; early diagnosis critical. Untreated cases can lead to severe complications.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Severe malaria, organ failure, cerebral malaria, hypoglycemia.

Microsporidiosis

Specialty: Infectious Diseases

Category: Parasitic Infections

Symptoms:
chronic diarrhea; abdominal pain; weight loss; nausea; vomiting; fever; ocular inflammation (in cases of eye involvement)

Root Cause:
Caused by microsporidia, intracellular parasites primarily affecting immunocompromised individuals.

How it's Diagnosed: videos
Microscopy (modified trichrome stain), PCR, and electron microscopy.

Treatment:
Antiparasitic medications, rehydration therapy, and managing underlying immunosuppression.

Medications:
Albendazole (a broad-spectrum antiparasitic) for systemic infections; fumagillin or topical agents for ocular infections.

Prevalence: How common the health condition is within a specific population.
Found worldwide, particularly in HIV/AIDS patients and organ transplant recipients.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Immunosuppression (e.g., HIV/AIDS, chemotherapy), exposure to contaminated water or food.

Prognosis: The expected outcome or course of the condition over time.
Treatable, but complications are more severe in immunocompromised individuals.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Chronic malabsorption, systemic spread, and severe organ-specific infections.

Sarcosporidiosis

Specialty: Infectious Diseases

Category: Parasitic Infections

Symptoms:
muscle pain; weakness; fever; diarrhea; nausea; subcutaneous nodules

Root Cause:
Caused by Sarcocystis parasites, typically transmitted through the ingestion of undercooked meat containing parasitic cysts or contaminated water.

How it's Diagnosed: videos
Stool examination for oocysts, muscle biopsy for cyst identification, and serological tests for antibodies.

Treatment:
Management includes supportive care for symptomatic relief and antiparasitic medications for severe cases.

Medications:
Albendazole , an antiparasitic, is often prescribed. Corticosteroids may be used to manage inflammation in severe cases.

Prevalence: How common the health condition is within a specific population.
Rare in developed countries; prevalence higher in regions with poor sanitation and raw meat consumption.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Consumption of undercooked meat, poor sanitation, exposure to contaminated water.

Prognosis: The expected outcome or course of the condition over time.
Generally good with treatment, though chronic muscle symptoms may persist in some cases.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Chronic muscle pain, weakness, and rare cases of systemic involvement.

Tapeworm Infestation

Specialty: Infectious Diseases

Category: Parasitic Infections

Symptoms:
abdominal pain; nausea; diarrhea; weight loss; visible segments in stool

Root Cause:
Caused by ingestion of Taenia or other tapeworm species through undercooked meat or contaminated water.

How it's Diagnosed: videos
Stool sample analysis, serological tests for antibodies, and imaging for cysts.

Treatment:
Antiparasitic medication with symptomatic relief for gastrointestinal discomfort.

Medications:
Praziquantel and albendazole , classified as antiparasitics.

Prevalence: How common the health condition is within a specific population.
Common in regions with poor food safety and hygiene; global cases vary by tapeworm species.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Eating undercooked or raw meat, poor hygiene, and exposure to contaminated water or food.

Prognosis: The expected outcome or course of the condition over time.
Good with treatment, but untreated cases may lead to severe complications.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Intestinal blockage, cysticercosis, and neurocysticercosis (when cysts develop in the brain).

Mediterranean Spotted Fever (Boutonneuse Fever)

Specialty: Infectious Diseases

Category: Skin and Soft-Tissue Infections

Symptoms:
fever; rash resembling red spots; eschar at the site of tick bite; headache; muscle pain; nausea

Root Cause:
Caused by Rickettsia conorii, transmitted through the bite of an infected tick.

How it's Diagnosed: videos
Clinical presentation, history of tick exposure, and confirmed through serological testing (indirect immunofluorescence or PCR).

Treatment:
Antibiotic therapy, primarily doxycycline.

Medications:
Doxycycline (a tetracycline antibiotic) is the primary treatment. Chloramphenicol can be used as an alternative in some cases.

Prevalence: How common the health condition is within a specific population.
Occurs mainly in the Mediterranean region, Africa, and parts of Asia; seasonal prevalence tied to tick activity.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Exposure to tick-infested areas, outdoor activities, lack of tick prevention measures.

Prognosis: The expected outcome or course of the condition over time.
Good with prompt treatment; untreated cases may result in severe complications.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Severe multi-organ failure, septic shock, myocarditis, and neurological symptoms in untreated cases.

Arenaviruses

Specialty: Infectious Diseases

Category: Viral Infections

Symptoms:
fever; headache; myalgia; nausea; vomiting; hemorrhagic symptoms in severe cases

Root Cause:
Caused by arenaviruses, which are RNA viruses transmitted through rodent hosts. Some species can cause hemorrhagic fevers.

How it's Diagnosed: videos
PCR testing, serological testing, and virus isolation in specialized laboratories.

Treatment:
Supportive care; ribavirin (an antiviral medication) may be used in some cases.

Medications:
Ribavirin , an antiviral agent classified as a nucleoside analog.

Prevalence: How common the health condition is within a specific population.
Rare but can occur in endemic regions where rodent reservoirs are prevalent.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Exposure to infected rodents, living in endemic areas, poor sanitation.

Prognosis: The expected outcome or course of the condition over time.
Depends on the specific arenavirus; Lassa fever has a case fatality rate of 1-15%. Early treatment improves outcomes.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Hemorrhagic fever, multi-organ failure, and death in severe cases.

Chikungunya Virus Infection

Specialty: Infectious Diseases

Category: Viral Infections

Symptoms:
fever; severe joint pain; rash; headache; nausea

Root Cause:
Caused by Chikungunya virus, transmitted by Aedes mosquitoes, leading to systemic inflammation and viral replication.

How it's Diagnosed: videos
Diagnosed via PCR, serology (IgM/IgG antibodies), or viral culture.

Treatment:
Symptomatic treatment with NSAIDs, hydration, and rest; no specific antiviral available.

Medications:
NSAIDs like ibuprofen or acetaminophen for pain and fever.

Prevalence: How common the health condition is within a specific population.
Endemic in tropical and subtropical regions; outbreaks reported globally due to travel and mosquito spread.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Living in or traveling to endemic areas, exposure to mosquito bites, lack of vector control measures.

Prognosis: The expected outcome or course of the condition over time.
Generally self-limiting; joint pain may persist for months.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Chronic arthritis, encephalitis, myocarditis, and rarely death in vulnerable populations.

Lymphocytic Choriomeningitis Virus (LCMV) Infection

Specialty: Infectious Diseases

Category: COVID-19 Reinfections

Symptoms:
fever; malaise; headache; nausea; vomiting; stiff neck; photophobia; confusion

Root Cause:
Infection caused by the LCMV, a rodent-borne arenavirus, leading to aseptic meningitis or meningoencephalitis in severe cases.

How it's Diagnosed: videos
Detection of LCMV-specific antibodies in cerebrospinal fluid (CSF) or blood, PCR for viral RNA, and history of exposure to rodents.

Treatment:
Supportive care, including pain management, anti-inflammatory medications, and fluid therapy; antivirals like ribavirin may be used experimentally.

Medications:
No FDA-approved specific treatment; ribavirin (antiviral) is sometimes used off-label for severe cases.

Prevalence: How common the health condition is within a specific population.
Rare; exposure often occurs via infected rodents or their excreta, with occasional outbreaks in specific regions.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Exposure to rodents, handling pet hamsters, and living in environments with poor rodent control.

Prognosis: The expected outcome or course of the condition over time.
Generally good with supportive care; severe cases can result in neurological complications or, rarely, death.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Neurological deficits, hydrocephalus, hearing loss, and miscarriage during pregnancy.

Norovirus

Specialty: Infectious Diseases

Category: COVID-19 Reinfections

Symptoms:
nausea; vomiting; diarrhea; abdominal cramps; fever; body aches; dehydration (in severe cases)

Root Cause:
Norovirus infection occurs when the virus infects the gastrointestinal tract, causing acute inflammation of the stomach and intestines. It is highly contagious and primarily spreads through contaminated food, water, surfaces, or direct contact.

How it's Diagnosed: videos
Diagnosis is usually clinical, based on symptoms and outbreak context. Laboratory testing (RT-PCR or enzyme immunoassay) can confirm norovirus presence in stool samples.

Treatment:
No specific antiviral treatment is available. Management focuses on supportive care, such as rehydration therapy (oral or IV) to replace lost fluids and electrolytes.

Medications:
There are no medications specifically targeting norovirus. Anti-nausea drugs like ondansetron (a serotonin 5-HT3 receptor antagonist) may be prescribed for severe vomiting. Oral rehydration salts (ORS) or electrolyte solutions help prevent dehydration.

Prevalence: How common the health condition is within a specific population.
Norovirus causes approximately 685 million cases worldwide annually, with a significant impact on children under five years and older adults.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Close contact with infected individuals, consuming contaminated food or water, living in crowded environments (e.g., nursing homes, cruise ships), poor hand hygiene.

Prognosis: The expected outcome or course of the condition over time.
Generally self-limiting; symptoms resolve within 1-3 days. Proper hydration ensures full recovery in most cases.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Severe dehydration, especially in young children, older adults, and immunocompromised individuals; rare cases of persistent gastrointestinal symptoms in vulnerable populations.

Thogotoviruses/Bourbon Virus

Specialty: Infectious Diseases

Category: COVID-19 Reinfections

Symptoms:
fever; fatigue; muscle aches; headache; nausea; vomiting; rash

Root Cause:
Caused by the Bourbon virus, transmitted by ticks; results in systemic viral infection and immune response.

How it's Diagnosed: videos
Diagnosis is confirmed by PCR testing or serology to detect Bourbon virus antibodies.

Treatment:
Supportive care, including hydration, pain management, and fever control. No specific antiviral treatment.

Medications:
Acetaminophen (analgesic) and ibuprofen (anti-inflammatory) can be used to alleviate symptoms.

Prevalence: How common the health condition is within a specific population.
Extremely rare, with only a handful of cases reported in the United States.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Tick exposure, rural areas, outdoor activities in tick-endemic regions.

Prognosis: The expected outcome or course of the condition over time.
Generally mild to moderate disease; however, severe cases may lead to organ failure.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Organ failure, septic shock, death in severe cases.