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Category:

Viral Hepatitis Complications

Number of Conditions: 1

Cutaneous Manifestations of Hepatitis C

Specialty: Infectious Diseases

Category: Viral Hepatitis Complications

Sub-category: Dermatologic Disorders

Symptoms:
lichen planus; cryoglobulinemic vasculitis; porphyria cutanea tarda; necrotizing vasculitis; urticaria

Root Cause:
Immune-mediated responses or direct effects of chronic Hepatitis C virus (HCV) infection causing dermatologic manifestations.

How it's Diagnosed: videos
Hepatitis C serology (anti-HCV antibodies), HCV RNA PCR testing, skin biopsy for specific lesions.

Treatment:
Management of HCV with direct-acting antiviral agents (e.g., sofosbuvir, ledipasvir) combined with treatments specific to the dermatologic condition.

Medications:
Direct-acting antivirals (e.g., sofosbuvir —an HCV polymerase inhibitor; ribavirin —antiviral therapy). Dermatologic treatments include corticosteroids or immunosuppressants for inflammatory skin conditions.

Prevalence: How common the health condition is within a specific population.
HCV affects approximately 1% of the global population; skin manifestations occur in 15–20% of those infected.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Chronic HCV infection, co-infection with other viruses, and poor immune response.

Prognosis: The expected outcome or course of the condition over time.
Good with antiviral therapy; most dermatologic symptoms improve with successful HCV treatment.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Progressive liver disease, systemic vasculitis, and persistent skin conditions.