Comprehensive Symptom Navigator™
Your health assistant, simplified.
Disclaimer: This is just an assistant. It should not be used for diagnosing patients without a doctor's discretion.
Symptoms:
Number of Conditions: 216
Peptic Ulcers
Specialty: Internal Medicine
Category: Digestive and Gastrointestinal Conditions
Symptoms:
burning stomach pain; bloating; nausea; vomiting; dark or tarry stools; fatigue (from anemia)
Root Cause:
Erosion of the stomach or duodenal lining, often due to Helicobacter pylori infection or long-term NSAID use.
How it's Diagnosed: videos
Upper endoscopy, H. pylori testing (breath, stool, or biopsy).
Treatment:
Antibiotics for H. pylori, acid suppression therapy, lifestyle changes.
Medications:
PPIs (e.g., omeprazole ), H2 receptor blockers (e.g., ranitidine), antibiotics (e.g., amoxicillin and clarithromycin for H. pylori).
Prevalence:
How common the health condition is within a specific population.
Affects about 5–10% of the population at some point in life.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
H. pylori infection, NSAID use, smoking, stress, alcohol consumption.
Prognosis:
The expected outcome or course of the condition over time.
Good with treatment; recurrence possible if underlying causes persist.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Bleeding, perforation, gastric obstruction, increased cancer risk.
Gallbladder Issues (Mild)
Specialty: Internal Medicine
Category: Digestive and Gastrointestinal Conditions
Symptoms:
right upper abdominal pain; nausea; vomiting; indigestion; pain after eating fatty meals
Root Cause:
Gallstones (cholelithiasis) or inflammation (cholecystitis) impairing gallbladder function.
How it's Diagnosed: videos
Ultrasound, liver function tests, HIDA scan.
Treatment:
Dietary modifications, pain management; surgery if recurrent or severe.
Medications:
Analgesics (e.g., acetaminophen ), ursodeoxycholic acid for gallstone dissolution (rarely used).
Prevalence:
How common the health condition is within a specific population.
Affects 10–15% of adults; more common in women.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Obesity, high-fat diet, pregnancy, rapid weight loss.
Prognosis:
The expected outcome or course of the condition over time.
Good with management; severe cases may require cholecystectomy.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Biliary colic, pancreatitis, bile duct obstruction.
Migraines and Headaches
Specialty: Internal Medicine
Category: Neurological and Mental Health Conditions
Symptoms:
throbbing or pulsating headache; sensitivity to light and sound; nausea; vomiting; aura (visual or sensory disturbances) in some cases
Root Cause:
Thought to involve abnormal brain activity affecting nerve signals, chemicals, and blood vessels.
How it's Diagnosed: videos
Clinical history, symptom patterns, ruling out other causes with imaging if necessary.
Treatment:
Preventive measures, acute treatment during attacks, lifestyle modifications.
Medications:
Triptans (e.g., sumatriptan ), NSAIDs (e.g., ibuprofen ), antiemetics (e.g., metoclopramide ), preventive drugs like beta-blockers (e.g., propranolol ), anticonvulsants (e.g., topiramate ), CGRP inhibitors (e.g., erenumab ).
Prevalence:
How common the health condition is within a specific population.
Affects about 12% of the population globally; more common in women.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Stress, hormonal changes, certain foods or drinks, sleep disturbances, family history.
Prognosis:
The expected outcome or course of the condition over time.
Manageable; frequency and severity often decrease with treatment and lifestyle changes.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Medication overuse headaches, chronic migraines, reduced quality of life.
Kidney Infections (Pyelonephritis)
Specialty: Internal Medicine
Category: Genitourinary and Reproductive Health
Symptoms:
fever; flank pain; nausea; vomiting; chills; painful urination; cloudy or foul-smelling urine
Root Cause:
Bacterial infection ascending from the bladder to the kidneys.
How it's Diagnosed: videos
Urinalysis, urine culture, imaging (e.g., CT or ultrasound for severe cases).
Treatment:
Antibiotics, hydration, hospitalization in severe cases.
Medications:
Ciprofloxacin , ceftriaxone , trimethoprim-sulfamethoxazole.
Prevalence:
How common the health condition is within a specific population.
Affects 1–2% of women annually; less common in men.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
UTIs, kidney stones, diabetes, urinary obstruction.
Prognosis:
The expected outcome or course of the condition over time.
Good with prompt treatment.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Sepsis, kidney damage, abscess formation.
Food Allergies
Specialty: Internal Medicine
Category: Allergic and Immunological Conditions
Symptoms:
hives; swelling of lips, face, or tongue; abdominal pain; vomiting; diarrhea; itchy throat; anaphylaxis (severe cases)
Root Cause:
Immune system overreaction to specific proteins in foods (e.g., nuts, shellfish, eggs).
How it's Diagnosed: videos
Clinical history, skin prick testing, blood tests for specific IgE antibodies, oral food challenge (under supervision).
Treatment:
Avoidance of trigger foods, emergency treatment for severe reactions.
Medications:
Antihistamines (e.g., diphenhydramine ) for mild symptoms, epinephrine autoinjector for anaphylaxis.
Prevalence:
How common the health condition is within a specific population.
Affects about 6–8% of children and 2–3% of adults globally.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Family history, other allergies (e.g., asthma, eczema), early exposure to allergens.
Prognosis:
The expected outcome or course of the condition over time.
Good with strict avoidance; children may outgrow some allergies.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Anaphylaxis, nutritional deficiencies if dietary restrictions are poorly managed.
Vertigo (e.g., Benign Paroxysmal Positional Vertigo - BPPV)
Specialty: Internal Medicine
Category: Eye, Ear, Nose, and Throat (ENT) Conditions
Symptoms:
spinning sensation; loss of balance; nausea; vomiting; nystagmus (involuntary eye movement)
Root Cause:
Displacement of calcium crystals (otoliths) in the inner ear, affecting balance.
How it's Diagnosed: videos
Dix-Hallpike maneuver, clinical history, imaging (if atypical symptoms).
Treatment:
Repositioning maneuvers (e.g., Epley maneuver), medications for symptom relief in acute episodes.
Medications:
Antihistamines (e.g., meclizine ), benzodiazepines (e.g., diazepam ) for severe episodes.
Prevalence:
How common the health condition is within a specific population.
BPPV is the most common cause of peripheral vertigo; affects about 1–2% of the population annually.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Aging, head trauma, vestibular disorders.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with proper treatment; symptoms often resolve with repositioning maneuvers.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Falls, persistent imbalance, anxiety about recurrent episodes.
Inborn Errors of Metabolism
Specialty: Pediatrics
Category: Neonatal Conditions (Newborns)
Sub-category: Metabolic and Endocrine Disorders
Symptoms:
poor feeding; lethargy; vomiting; failure to thrive; seizures; distinctive odor in urine (e.g., maple syrup in msud); jaundice; hypoglycemia
Root Cause:
Genetic defects affecting enzymes in metabolic pathways, leading to toxic accumulation of intermediates or energy deficiency.
How it's Diagnosed: videos
Newborn screening (heel-prick blood tests); confirmatory tests include enzyme assays, genetic testing, and metabolite analysis in blood or urine.
Treatment:
Dietary management (e.g., protein restriction for MSUD or lactose-free formula for galactosemia); emergency interventions for metabolic crises (e.g., intravenous glucose or dialysis).
Medications:
No specific medications for many conditions; dietary supplements such as thiamine (MSUD) or calcium (galactosemia) may be prescribed.
Prevalence:
How common the health condition is within a specific population.
Rare; varies by condition and population (e.g., MSUD prevalence
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Autosomal recessive inheritance; increased risk in consanguineous marriages or certain ethnic groups (e.g., Mennonite populations for MSUD).
Prognosis:
The expected outcome or course of the condition over time.
Depends on the condition; early diagnosis and strict adherence to dietary management can lead to good outcomes; delayed treatment can result in severe neurological damage or death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Acute metabolic crises, intellectual disability, developmental delay, organ damage (e.g., liver failure in galactosemia).
Acute Gastroenteritis
Specialty: Pediatrics
Category: Gastrointestinal Disorders
Sub-category: Infectious and Inflammatory Disorders
Symptoms:
diarrhea; nausea; vomiting; abdominal cramps; fever; dehydration
Root Cause:
Inflammation of the stomach and intestines caused by viral, bacterial, or parasitic infections.
How it's Diagnosed: videos
Clinical history, physical examination, stool tests (to identify causative pathogen), and sometimes blood tests if dehydration or severe infection is suspected.
Treatment:
Rehydration therapy (oral or IV), dietary adjustments, and in some cases, antimicrobial therapy for bacterial or parasitic infections.
Medications:
Antiemetics (e.g., ondansetron ), antidiarrheals (e.g., loperamide ), antibiotics (e.g., azithromycin for bacterial infections like Campylobacter or Shigella), and antiparasitics (e.g., metronidazole for Giardia).
Prevalence:
How common the health condition is within a specific population.
Affects millions globally, especially in children under five, with higher prevalence in low-resource settings.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Poor sanitation, contaminated food or water, daycare settings, international travel.
Prognosis:
The expected outcome or course of the condition over time.
Generally good with supportive care; most cases resolve in a few days without complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Severe dehydration, electrolyte imbalance, malnutrition, hemolytic uremic syndrome (HUS) in some bacterial infections.
Hepatitis (A, B, C, Autoimmune)
Specialty: Pediatrics
Category: Gastrointestinal Disorders
Sub-category: Infectious and Autoimmune Disorders
Symptoms:
jaundice; fatigue; abdominal pain; dark urine; light-colored stool; nausea; vomiting
Root Cause:
Liver inflammation caused by viral infections (Hepatitis A, B, C) or immune-mediated attack on liver cells (Autoimmune Hepatitis).
How it's Diagnosed: videos
Blood tests (liver enzymes, viral serology, autoimmune markers), liver ultrasound, and sometimes liver biopsy.
Treatment:
Hepatitis A
Medications:
Antivirals (e.g., tenofovir , entecavir for Hepatitis B; sofosbuvir , ribavirin for Hepatitis C), corticosteroids (e.g., prednisone for Autoimmune Hepatitis), and immunosuppressants (e.g., azathioprine ).
Prevalence:
How common the health condition is within a specific population.
Hepatitis A and B
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Poor hygiene (Hepatitis A), unvaccinated status (Hepatitis B), needle sharing (Hepatitis C), genetic predisposition (Autoimmune Hepatitis).
Prognosis:
The expected outcome or course of the condition over time.
Hepatitis A
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic liver disease, cirrhosis, hepatocellular carcinoma, liver failure.
Diabetic Ketoacidosis (DKA)
Specialty: Diabetes and Endocrinology
Category: Diabetes Mellitus and Related Disorders
Sub-category: Acute Complications
Symptoms:
excessive thirst; frequent urination; nausea; vomiting; abdominal pain; shortness of breath; fruity-smelling breath; confusion
Root Cause:
Insulin deficiency leads to uncontrolled hyperglycemia, lipolysis, and ketone production, causing metabolic acidosis.
How it's Diagnosed: videos
Blood tests showing high blood glucose, ketonemia, low bicarbonate, and arterial blood pH < 7.3; urine tests for ketones.
Treatment:
Intravenous fluids, insulin therapy, electrolyte replacement (potassium), and treating underlying causes (e.g., infection).
Medications:
Regular insulin administered intravenously to reduce blood glucose and ketone levels.
Prevalence:
How common the health condition is within a specific population.
Common in individuals with type 1 diabetes; can occur in type 2 diabetes during severe stress.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Poor diabetes management, infection, trauma, surgery, or missed insulin doses.
Prognosis:
The expected outcome or course of the condition over time.
Early treatment leads to recovery; delayed treatment may result in coma or death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Cerebral edema, hypokalemia, arrhythmias, and death.
Adrenal insufficiency (e.g., Addison’s disease)
Specialty: Pediatrics
Category: Endocrine Disorders
Sub-category: Other Endocrine Issues
Symptoms:
fatigue; weight loss; low blood pressure; hyperpigmentation of the skin; abdominal pain; nausea; vomiting; salt cravings; hypoglycemia
Root Cause:
Insufficient production of cortisol and/or aldosterone by the adrenal glands, often due to autoimmune destruction, infection, or adrenal gland damage.
How it's Diagnosed: videos
Blood tests measuring cortisol and ACTH levels, ACTH stimulation test, electrolyte panels, and imaging studies (e.g., CT or MRI of the adrenal glands).
Treatment:
Hormone replacement therapy, including glucocorticoids (e.g., hydrocortisone) and mineralocorticoids (e.g., fludrocortisone), along with lifestyle adjustments and emergency injectable hydrocortisone for adrenal crises.
Medications:
Hydrocortisone or prednisone (glucocorticoids) replace cortisol; fludrocortisone (a mineralocorticoid) replaces aldosterone. Glucocorticoids are corticosteroids, while fludrocortisone is a mineralocorticoid.
Prevalence:
How common the health condition is within a specific population.
Rare, affecting approximately 1 in 10,000 to 20,000 people globally.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Autoimmune conditions (e.g., autoimmune polyendocrine syndrome), family history, infections (e.g., tuberculosis), adrenal gland damage due to trauma or surgery.
Prognosis:
The expected outcome or course of the condition over time.
With appropriate treatment, patients can lead normal lives; however, untreated adrenal insufficiency can be life-threatening.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Adrenal crisis (acute life-threatening condition), electrolyte imbalances, hypoglycemia, and increased susceptibility to stress-related illnesses.
Food allergies
Specialty: Pediatrics
Category: Immunologic and Rheumatologic Disorders
Sub-category: Allergic Disorders
Symptoms:
hives; swelling of lips, face, tongue, or throat; difficulty breathing; vomiting; diarrhea; abdominal pain; anaphylaxis (severe, life-threatening allergic reaction)
Root Cause:
The immune system mistakenly identifies certain proteins in food as harmful and releases chemicals like histamine to protect the body, triggering an allergic reaction.
How it's Diagnosed: videos
Diagnosis typically involves a detailed medical history, skin prick tests, blood tests for allergen-specific IgE antibodies, and food challenge tests under medical supervision.
Treatment:
The main treatment is avoiding the allergenic food. In case of accidental exposure, antihistamines can be used for mild reactions, while epinephrine (adrenaline) is prescribed for severe reactions or anaphylaxis.
Medications:
Common medications include antihistamines (e.g., cetirizine , loratadine , which are antihistamines used to reduce allergic reactions) and epinephrine (e.g., epinephrine auto-injectors like EpiPen or Auvi-Q for emergency treatment of anaphylaxis). Antihistamines are classified as H1 receptor antagonists, and epinephrine is a sympathomimetic drug.
Prevalence:
How common the health condition is within a specific population.
Food allergies affect about 8% of children, with some studies showing a growing trend in allergic reactions, especially to peanuts, eggs, milk, and shellfish.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Family history of allergies, other allergic conditions (e.g., eczema or allergic rhinitis), early exposure to allergens, and living in urban areas with less exposure to diverse environmental microbes.
Prognosis:
The expected outcome or course of the condition over time.
Many children outgrow food allergies as they age, though some food allergies (e.g., peanuts, tree nuts, fish, and shellfish) tend to persist into adulthood.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Anaphylaxis, which can be fatal if untreated, chronic allergic reactions leading to eczema or other skin conditions, and the psychological impact of living with food restrictions.
Vasculitis (e.g., Henoch-Schönlein Purpura)
Specialty: Pediatrics
Category: Immunologic and Rheumatologic Disorders
Sub-category: Autoimmune Disorders
Symptoms:
purple spots on the skin (purpura); abdominal pain; joint pain; kidney involvement (hematuria); vomiting; diarrhea
Root Cause:
Vasculitis in Henoch-Schönlein purpura (HSP) occurs when the body's immune system mistakenly attacks small blood vessels, leading to inflammation and leakage of blood into the skin and other organs.
How it's Diagnosed: videos
Diagnosis is based on clinical presentation (rash, joint pain, abdominal symptoms) and laboratory tests (e.g., urine analysis for kidney involvement, elevated ESR/CRP).
Treatment:
Treatment is typically supportive, including NSAIDs for joint pain and corticosteroids for more severe cases or to prevent kidney damage.
Medications:
NSAIDs (e.g., ibuprofen ) for pain and inflammation, corticosteroids (such as prednisone ) for more severe symptoms or kidney involvement.
Prevalence:
How common the health condition is within a specific population.
HSP is the most common form of vasculitis in children, with an incidence of 10-20 per 100,000 children per year.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Typically follows an upper respiratory infection (e.g., streptococcal infection), genetic predisposition.
Prognosis:
The expected outcome or course of the condition over time.
Most children recover fully without long-term consequences; however, kidney damage can occur in a small percentage, leading to chronic kidney disease.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Kidney involvement (e.g., glomerulonephritis), gastrointestinal bleeding, and long-term joint pain.
Concussion and Traumatic Brain Injury (TBI)
Specialty: Emergency and Urgent Care
Category: Trauma and Injuries
Sub-category: Blunt Trauma
Symptoms:
headache; confusion; dizziness; nausea; vomiting; temporary loss of consciousness; difficulty concentrating; memory problems; sleep disturbances; mood changes
Root Cause:
Disruption in normal brain function due to a direct blow, jolt, or penetrating injury to the head causing mechanical damage to brain tissue.
How it's Diagnosed: videos
Clinical evaluation, Glasgow Coma Scale (GCS), neurological exam, imaging studies (CT scan or MRI).
Treatment:
Rest, symptom management, physical and cognitive rehabilitation, and monitoring for complications.
Medications:
Pain relievers (acetaminophen ), anti-nausea medications, and sometimes anticonvulsants (e.g., phenytoin ) or diuretics (e.g., mannitol ) to reduce intracranial pressure.
Prevalence:
How common the health condition is within a specific population.
Millions of cases worldwide annually, with mild TBI (concussion) being the most common.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Sports injuries, motor vehicle accidents, falls, and assaults.
Prognosis:
The expected outcome or course of the condition over time.
Most mild TBIs resolve with proper care; severe TBIs may result in lasting neurological deficits or disability.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Post-concussion syndrome, chronic traumatic encephalopathy (CTE), seizures, and long-term cognitive or psychological impairments.
Appendicitis
Specialty: Gastrointestinal
Category: General and Miscellaneous GI Conditions
Sub-category: Abdominal Pain and Disorders
Symptoms:
sudden pain in the lower right abdomen; nausea; vomiting; loss of appetite; fever; constipation or diarrhea
Root Cause:
Inflammation of the appendix, often due to obstruction of the appendiceal lumen by fecaliths, lymphoid hyperplasia, or other blockages.
How it's Diagnosed: videos
Clinical evaluation of symptoms, imaging (ultrasound or CT scan), and blood tests showing elevated white blood cell count and inflammatory markers.
Treatment:
Surgical removal of the appendix (appendectomy) is the standard treatment, sometimes preceded by antibiotics in uncomplicated cases.
Medications:
Antibiotics such as ceftriaxone or metronidazole are prescribed preoperatively and postoperatively in some cases to manage or prevent infection.
Prevalence:
How common the health condition is within a specific population.
Affects approximately 7% of the population, most commonly in individuals aged 10-30 years.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Family history, high-fat/low-fiber diets, and gastrointestinal infections.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with timely diagnosis and treatment; recovery is typically quick following surgery.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Perforation of the appendix, peritonitis, abscess formation, and sepsis in untreated or delayed cases.
Cholecystitis
Specialty: Emergency and Urgent Care
Category: Gastrointestinal Emergencies
Sub-category: Acute Abdominal Pain
Symptoms:
right upper quadrant abdominal pain; nausea; vomiting; fever; pain radiating to the shoulder or back; tenderness in the right upper quadrant
Root Cause:
Inflammation of the gallbladder, usually due to obstruction of the cystic duct by gallstones.
How it's Diagnosed: videos
Clinical examination, abdominal ultrasound, HIDA scan, and elevated inflammatory markers (WBC, CRP).
Treatment:
Fasting (NPO), intravenous fluids, pain control, antibiotics, and cholecystectomy (surgical removal of the gallbladder).
Medications:
Broad-spectrum antibiotics such as piperacillin-tazobactam (penicillin class) or ceftriaxone with metronidazole are commonly prescribed. NSAIDs or opioids for pain management.
Prevalence:
How common the health condition is within a specific population.
Affects about 10-15% of the adult population, with acute cholecystitis being a complication in a smaller proportion.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Female gender, obesity, pregnancy, age over 40, rapid weight loss, high-fat diet.
Prognosis:
The expected outcome or course of the condition over time.
Good with prompt treatment; untreated cases can lead to severe complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Gallbladder rupture, peritonitis, sepsis, emphysematous cholecystitis.
Pancreatitis
Specialty: Emergency and Urgent Care
Category: Gastrointestinal Emergencies
Sub-category: Acute Abdominal Pain
Symptoms:
severe upper abdominal pain; pain radiating to the back; nausea; vomiting; fever; abdominal tenderness; jaundice in some cases
Root Cause:
Inflammation of the pancreas due to gallstones, alcohol use, or other factors like hypertriglyceridemia or trauma.
How it's Diagnosed: videos
Clinical assessment, elevated serum amylase and lipase levels, abdominal ultrasound, or CT scan.
Treatment:
Supportive care with fasting (NPO), IV fluids, pain control, and treating the underlying cause (e.g., gallstone removal). Severe cases may require intensive care or surgical intervention.
Medications:
Analgesics such as morphine (opioid) or NSAIDs for pain; antibiotics only in cases of infected pancreatic necrosis.
Prevalence:
How common the health condition is within a specific population.
About 50 cases per 100,000 annually in developed countries.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Alcohol abuse, gallstones, high triglycerides, smoking, certain medications.
Prognosis:
The expected outcome or course of the condition over time.
Varies; mild cases resolve in days, while severe cases can lead to multi-organ failure.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Pancreatic necrosis, pseudocysts, infection, systemic inflammatory response syndrome (SIRS).
Perforated Viscus
Specialty: Emergency and Urgent Care
Category: Gastrointestinal Emergencies
Sub-category: Acute Abdominal Pain
Symptoms:
sudden severe abdominal pain; rigid abdomen; fever; nausea; vomiting; hypotension; tachycardia
Root Cause:
Perforation of the gastrointestinal tract, leading to leakage of contents into the abdominal cavity and peritonitis. Common causes include peptic ulcers, diverticulitis, or trauma.
How it's Diagnosed: videos
Clinical examination, X-ray or CT showing free air under the diaphragm (pneumoperitoneum), and blood tests for infection markers.
Treatment:
Emergency surgery to repair the perforation, IV antibiotics, and supportive care.
Medications:
Broad-spectrum antibiotics like ceftriaxone with metronidazole or piperacillin-tazobactam to manage peritonitis. Pain relief with opioids.
Prevalence:
How common the health condition is within a specific population.
Rare but life-threatening, particularly in patients with peptic ulcers or diverticulitis.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
NSAID use, corticosteroids, smoking, alcohol use, peptic ulcer disease, trauma.
Prognosis:
The expected outcome or course of the condition over time.
Depends on timely intervention; high mortality without treatment.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Sepsis, multi-organ failure, death.
Hernias (Incarcerated, Strangulated)
Specialty: Emergency and Urgent Care
Category: Gastrointestinal Emergencies
Sub-category: Other GI Conditions
Symptoms:
localized pain or tenderness at the hernia site; nausea; vomiting; abdominal distension; redness or discoloration over the hernia; inability to pass stool or gas
Root Cause:
A portion of an organ, typically the intestine, becomes trapped in the hernia sac, compromising blood flow (strangulated) or causing obstruction without blood flow compromise (incarcerated).
How it's Diagnosed: videos
Physical examination, imaging studies such as ultrasound or CT scan, and observation of symptoms like persistent pain and obstruction signs.
Treatment:
Emergent surgical intervention to release the trapped organ and repair the hernia; in severe cases, resection of necrotic tissue may be required.
Medications:
Pain management with opioids or NSAIDs, and prophylactic antibiotics like cefazolin (a first-generation cephalosporin) to reduce infection risk.
Prevalence:
How common the health condition is within a specific population.
Incarcerated hernias are relatively common, with about 10-15% of hernias progressing to incarceration; strangulated hernias occur in approximately 1-3% of cases.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Older age, male gender, obesity, chronic coughing or straining, history of previous hernias, heavy lifting.
Prognosis:
The expected outcome or course of the condition over time.
Good with timely surgical intervention; delayed treatment can lead to bowel necrosis, sepsis, and increased mortality.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Bowel obstruction, ischemia, necrosis, perforation, and sepsis.
Mesenteric Ischemia
Specialty: Emergency and Urgent Care
Category: Gastrointestinal Emergencies
Sub-category: Vascular GI Conditions
Symptoms:
sudden severe abdominal pain; nausea; vomiting; diarrhea; blood in stool; abdominal distension
Root Cause:
Reduced or completely obstructed blood flow to the intestines due to arterial embolism, arterial thrombosis, or venous thrombosis.
How it's Diagnosed: videos
Clinical history and physical exam, blood tests (elevated lactate levels), imaging studies (CT angiography is the gold standard).
Treatment:
Immediate resuscitation, anticoagulation (e.g., heparin), thrombolysis, and surgical intervention to remove occlusion or resect necrotic bowel.
Medications:
Anticoagulants like heparin (unfractionated or low-molecular-weight), thrombolytics like alteplase (tissue plasminogen activator), and vasodilators like papaverine (to improve blood flow).
Prevalence:
How common the health condition is within a specific population.
Rare but life-threatening, affecting approximately 0.1-0.2% of hospital admissions; more common in elderly individuals.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Atrial fibrillation, heart failure, atherosclerosis, recent abdominal surgery, hypercoagulable states.
Prognosis:
The expected outcome or course of the condition over time.
Poor if not treated promptly; mortality rates can exceed 70% for acute cases with bowel necrosis.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Bowel infarction, perforation, sepsis, multi-organ failure.
Severe Gastroenteritis
Specialty: Emergency and Urgent Care
Category: Gastrointestinal Emergencies
Sub-category: Infectious GI Conditions
Symptoms:
profuse diarrhea; vomiting; severe dehydration; abdominal cramping; fever; bloody stools (in some cases)
Root Cause:
Inflammation of the stomach and intestines caused by bacterial, viral, or parasitic infections, leading to fluid and electrolyte imbalances.
How it's Diagnosed: videos
Clinical history, stool tests (for pathogens), blood tests (to assess dehydration and electrolyte levels).
Treatment:
Rehydration with intravenous fluids, electrolyte replacement, and antimicrobial therapy if indicated.
Medications:
Oral rehydration salts (ORS), IV fluids (crystalloids like normal saline), antibiotics such as ciprofloxacin or azithromycin (for bacterial infections), and antiemetics like ondansetron .
Prevalence:
How common the health condition is within a specific population.
A leading cause of morbidity globally, with higher prevalence in developing countries; severe cases are less common but can be life-threatening, especially in children and the elderly.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Poor sanitation, contaminated food or water, travel to endemic regions, immunosuppression.
Prognosis:
The expected outcome or course of the condition over time.
Good with adequate hydration and timely treatment; delayed or inadequate treatment can lead to severe complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Severe dehydration, electrolyte imbalances, kidney failure, sepsis, death in extreme cases.
Diabetic ketoacidosis (DKA)
Specialty: Emergency and Urgent Care
Category: Endocrine and Metabolic Emergencies
Sub-category: Diabetes-Related Emergencies
Symptoms:
nausea; vomiting; abdominal pain; rapid breathing; fruity-scented breath; confusion; excessive thirst; frequent urination
Root Cause:
DKA occurs due to insufficient insulin, leading to uncontrolled hyperglycemia, ketone production, and metabolic acidosis.
How it's Diagnosed: videos
Clinical evaluation, laboratory tests showing hyperglycemia (blood glucose >250 mg/dL), ketonemia, ketonuria, low bicarbonate levels (<18 mEq/L), and an elevated anion gap metabolic acidosis.
Treatment:
Immediate fluid resuscitation (IV fluids), insulin therapy, electrolyte replacement (especially potassium), and addressing precipitating factors (e.g., infections).
Medications:
Regular insulin (short-acting insulin for IV infusion to lower blood glucose and suppress ketone production), potassium supplements (for electrolyte correction), bicarbonate (in severe acidosis cases, though used cautiously).
Prevalence:
How common the health condition is within a specific population.
Common in individuals with type 1 diabetes and occasionally in type 2 diabetes under stress or illness.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Poor diabetes management, infections, physical or emotional stress, skipping insulin doses, undiagnosed diabetes.
Prognosis:
The expected outcome or course of the condition over time.
Favorable if treated promptly; mortality is low with appropriate intervention but rises if untreated.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Cerebral edema (especially in children), hypokalemia, cardiac arrhythmias, hypoglycemia, and multi-organ failure in severe cases.
Thyroid Storm
Specialty: Emergency and Urgent Care
Category: Endocrine and Metabolic Emergencies
Sub-category: Thyroid Conditions
Symptoms:
high fever; rapid heart rate (tachycardia); extreme irritability or agitation; confusion or delirium; profuse sweating; nausea; vomiting; diarrhea; heart failure symptoms (chest pain, shortness of breath); goiter
Root Cause:
Excessive release of thyroid hormones (T3 and T4) leading to a hypermetabolic state, often triggered by infection, trauma, surgery, or discontinuation of antithyroid medications in patients with hyperthyroidism.
How it's Diagnosed: videos
Clinical presentation supported by laboratory findings of extremely elevated free T3 and T4 levels, suppressed TSH levels, and systemic organ dysfunction. Other tests may include CBC, liver enzymes, and imaging (to rule out precipitating factors).
Treatment:
Aggressive supportive care, cooling measures for hyperthermia, hydration, electrolyte correction, beta-blockers to control heart rate, antithyroid drugs, iodine to block thyroid hormone release, and corticosteroids to reduce peripheral conversion of T4 to T3.
Medications:
Antithyroid drugs
Prevalence:
How common the health condition is within a specific population.
Rare but life-threatening; typically occurs in patients with untreated or poorly managed hyperthyroidism.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Graves’ disease, toxic multinodular goiter, thyroid surgery, infection, trauma, pregnancy, discontinuation of antithyroid drugs, or iodine contrast administration.
Prognosis:
The expected outcome or course of the condition over time.
High mortality rate (up to 20-30%) if untreated; early and aggressive treatment significantly improves outcomes.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Heart failure, arrhythmias (e.g., atrial fibrillation), shock, multi-organ failure, and death.
Hyponatremia
Specialty: Nephrology
Category: Electrolyte and Acid-Base Disorders
Symptoms:
nausea; vomiting; confusion; headache; seizures; fatigue; restlessness; muscle weakness or spasms; coma in severe cases
Root Cause:
Low sodium concentration in the blood, often caused by excessive water retention, sodium loss, or a combination of both.
How it's Diagnosed: videos
Blood tests measuring serum sodium levels (<135 mEq/L), urine sodium and osmolality, and clinical evaluation of symptoms.
Treatment:
Treatment focuses on addressing the underlying cause, restricting fluid intake, or administering sodium supplementation. Severe cases may require hypertonic saline.
Medications:
Tolvaptan or conivaptan (vasopressin receptor antagonists), diuretics like loop diuretics (e.g., furosemide ) for certain cases, and sodium chloride for supplementation.
Prevalence:
How common the health condition is within a specific population.
Common, particularly in hospitalized patients; estimated at 15–30% in such settings.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Heart failure, liver cirrhosis, kidney disease, SIADH, use of diuretics, excessive water intake, and advanced age.
Prognosis:
The expected outcome or course of the condition over time.
Generally good if treated promptly, but severe hyponatremia can lead to permanent neurological damage or death if untreated.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Cerebral edema, seizures, coma, central pontine myelinolysis (from overly rapid correction).
Hypercalcemia
Specialty: Nephrology
Category: Electrolyte and Acid-Base Disorders
Symptoms:
nausea; vomiting; constipation; polyuria; kidney stones; confusion; lethargy; arrhythmias
Root Cause:
Elevated calcium levels in the blood due to increased bone resorption, excessive intake, or abnormal regulation by parathyroid hormone.
How it's Diagnosed: videos
Blood tests showing serum calcium >10.5 mg/dL, PTH levels, and clinical evaluation of symptoms.
Treatment:
IV fluids, bisphosphonates, calcitonin, and addressing the underlying cause (e.g., surgery for hyperparathyroidism).
Medications:
Bisphosphonates (e.g., pamidronate , zoledronic acid), calcitonin (reduces calcium levels), and corticosteroids for specific conditions.
Prevalence:
How common the health condition is within a specific population.
Common, particularly in patients with malignancy or hyperparathyroidism.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Hyperparathyroidism, malignancy, excessive calcium/vitamin D intake, and prolonged immobility.
Prognosis:
The expected outcome or course of the condition over time.
Good with proper treatment; severe hypercalcemia can lead to renal failure or cardiac arrest.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Kidney stones, nephrocalcinosis, arrhythmias, and neuropsychiatric disturbances.
Uremia
Specialty: Emergency and Urgent Care
Category: Renal and Urologic Emergencies
Sub-category: Renal Failure Complications
Symptoms:
nausea; vomiting; loss of appetite; fatigue; confusion; seizures; muscle cramps; itching; fluid retention; shortness of breath; high blood pressure; altered mental status
Root Cause:
Accumulation of urea and other nitrogenous waste products in the blood due to impaired kidney function. This condition arises from chronic or acute renal failure, leading to toxic effects on multiple organ systems.
How it's Diagnosed: videos
Blood tests showing elevated blood urea nitrogen (BUN) and creatinine levels, electrolyte imbalances, and metabolic acidosis; urinalysis may indicate proteinuria or hematuria; imaging (ultrasound or CT) may show kidney abnormalities. Clinical symptoms and history are also critical.
Treatment:
Emergency treatment includes dialysis (hemodialysis or peritoneal dialysis) to remove waste products and restore electrolyte balance. Supportive care includes addressing fluid overload and managing complications such as hypertension and metabolic acidosis.
Medications:
Diuretics (e.g., furosemide )
Prevalence:
How common the health condition is within a specific population.
Common among individuals with advanced chronic kidney disease (CKD) or acute kidney injury (AKI); incidence rises in end-stage renal disease (ESRD) patients.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Chronic kidney disease, acute kidney injury, diabetes mellitus, hypertension, advanced age, polycystic kidney disease, and autoimmune disorders affecting the kidneys (e.g., lupus nephritis).
Prognosis:
The expected outcome or course of the condition over time.
With timely dialysis and treatment, symptoms can be managed effectively; however, the underlying renal disease usually remains progressive without a transplant. Untreated uremia is life-threatening.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Cardiac arrhythmias, pericarditis, seizures, encephalopathy, fluid overload, and death if untreated.
Toxic Shock Syndrome
Specialty: Emergency and Urgent Care
Category: Infectious Diseases
Sub-category: Other Infectious Emergencies
Symptoms:
sudden high fever; low blood pressure; vomiting; diarrhea; rash resembling sunburn; confusion; seizures; muscle aches; redness of eyes, throat, and mouth; organ failure
Root Cause:
Caused by toxins produced by Staphylococcus aureus or Streptococcus pyogenes bacteria, often associated with tampon use, wound infections, or surgical procedures.
How it's Diagnosed: videos
Clinical evaluation based on symptoms, blood cultures, and other laboratory tests to identify the bacterial toxin.
Treatment:
Immediate hospitalization, intravenous fluids to maintain blood pressure, antibiotics to target bacteria, and management of organ dysfunction.
Medications:
Intravenous antibiotics such as clindamycin and vancomycin (antibacterials). IV immunoglobulins may also be used to neutralize toxins.
Prevalence:
How common the health condition is within a specific population.
Rare, with an incidence of approximately 1–2 cases per 100,000 population annually.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Prolonged tampon use, post-surgical infections, open wounds, childbirth, or nasal packing.
Prognosis:
The expected outcome or course of the condition over time.
Good with prompt treatment; however, untreated cases can be fatal.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Shock, organ failure, amputations due to necrosis, and death.
Tumor Lysis Syndrome
Specialty: Oncology
Category: Sarcomas
Sub-category: Treatment-Related Complications
Symptoms:
hyperkalemia; hyperphosphatemia; hypocalcemia; elevated creatinine; nausea; vomiting; fatigue; muscle cramps; seizures
Root Cause:
The rapid release of intracellular contents from dying tumor cells, often after chemotherapy or other treatments, leading to metabolic disturbances.
How it's Diagnosed: videos
Blood tests to measure levels of potassium, phosphate, calcium, creatinine, and uric acid. Clinical presentation and history of recent cancer treatment.
Treatment:
Hydration, medications to control electrolyte imbalances (e.g., sodium bicarbonate, allopurinol), dialysis if necessary, and monitoring in a hospital setting.
Medications:
Allopurinol (a xanthine oxidase inhibitor that reduces uric acid production), Rasburicase (an enzyme that breaks down uric acid), Sodium bicarbonate (to alkalinize urine and prevent uric acid crystallization), Calcium gluconate (to treat hypocalcemia), Potassium binders (to reduce hyperkalemia). These medications are considered urate-lowering agents, electrolyte modifiers, and anti-hyperkalemic agents.
Prevalence:
How common the health condition is within a specific population.
This is a relatively rare condition, occurring in approximately 5-10% of patients receiving chemotherapy for high-grade hematologic cancers like leukemia and lymphoma.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
High tumor burden, especially in hematologic malignancies, rapid tumor cell turnover, and treatments like chemotherapy or radiation therapy.
Prognosis:
The expected outcome or course of the condition over time.
With early detection and treatment, prognosis can be good. However, untreated tumor lysis syndrome can lead to organ failure and death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Renal failure, cardiac arrhythmias, seizures, and death if not managed promptly.
Acetaminophen overdose
Specialty: Emergency and Urgent Care
Category: Toxicology and Overdose
Sub-category: Drug Overdoses
Symptoms:
nausea; vomiting; abdominal pain; confusion; jaundice (late stage); elevated liver enzymes
Root Cause:
Excessive acetaminophen overwhelms the liver's ability to conjugate and detoxify NAPQI (toxic metabolite), causing hepatocellular damage.
How it's Diagnosed: videos
History of overdose, serum acetaminophen levels, and liver function tests (LFTs); use of the Rumack-Matthew nomogram for risk assessment.
Treatment:
N-acetylcysteine (NAC) administration (oral or IV) to replenish glutathione, activated charcoal if within 1-2 hours of ingestion, and supportive care.
Medications:
N-acetylcysteine (antidote for acetaminophen toxicity) and activated charcoal (gastric decontaminant).
Prevalence:
How common the health condition is within a specific population.
Acetaminophen toxicity is one of the most common causes of drug overdoses globally and a leading cause of acute liver failure in the U.S.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Chronic acetaminophen use, concurrent alcohol consumption, pre-existing liver disease, and taking higher-than-recommended doses.
Prognosis:
The expected outcome or course of the condition over time.
Good with early treatment; delayed treatment increases the risk of liver failure, necessitating a liver transplant.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Acute liver failure, metabolic acidosis, encephalopathy, and death.
Alcohol poisoning
Specialty: Emergency and Urgent Care
Category: Toxicology and Overdose
Sub-category: Substance Abuse
Symptoms:
confusion; vomiting; hypothermia; seizures; slow or irregular breathing; unconsciousness
Root Cause:
Excessive ethanol consumption depresses the central nervous system, impairs respiratory function, and leads to metabolic acidosis.
How it's Diagnosed: videos
Clinical presentation, serum ethanol levels, and assessment for metabolic derangements (ABG, electrolyte panel).
Treatment:
Airway protection, intravenous fluids, thiamine and glucose supplementation, and monitoring in an intensive care setting.
Medications:
Thiamine (to prevent Wernicke-Korsakoff syndrome) and glucose (to address hypoglycemia). No direct antidote for ethanol toxicity.
Prevalence:
How common the health condition is within a specific population.
Alcohol poisoning is a frequent emergency, especially among binge drinkers; accounts for thousands of deaths annually worldwide.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Binge drinking, alcohol use disorder, low body weight, and concurrent use of sedatives or opioids.
Prognosis:
The expected outcome or course of the condition over time.
Good with early intervention; severe cases can result in brain damage or death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Hypoglycemia, hypothermia, aspiration, respiratory depression, and death.
Snake Bites
Specialty: Emergency and Urgent Care
Category: Toxicology and Overdose
Sub-category: Envenomations
Symptoms:
localized pain and swelling; redness; bruising; nausea; vomiting; difficulty breathing; altered mental status; bleeding disorders; paralysis
Root Cause:
Snake venom contains a mixture of proteins, enzymes, and toxins that disrupt blood coagulation, damage tissues, and interfere with the nervous system or cardiovascular function.
How it's Diagnosed: videos
Clinical history, observation of bite marks, identification of the snake (if possible), blood tests for coagulation disorders, and monitoring for systemic effects.
Treatment:
Antivenom administration specific to the snake species, wound care, supportive care (e.g., IV fluids, oxygen), and monitoring for complications.
Medications:
Antivenom
Prevalence:
How common the health condition is within a specific population.
Estimated 5.4 million bites occur worldwide annually, with approximately 2.7 million envenomations and 81,000–138,000 deaths.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Outdoor activities in snake habitats, lack of protective footwear, delayed medical care, and inadequate access to antivenom.
Prognosis:
The expected outcome or course of the condition over time.
Good if treated promptly with appropriate antivenom; delayed treatment increases the risk of permanent damage or death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Tissue necrosis, compartment syndrome, coagulopathy, renal failure, and systemic shock.
Marine Envenomations (e.g., Jellyfish, Stingrays)
Specialty: Emergency and Urgent Care
Category: Toxicology and Overdose
Sub-category: Envenomations
Symptoms:
localized pain; burning or stinging sensation; redness and swelling; nausea; vomiting; difficulty breathing; muscle cramps; cardiac symptoms in severe cases
Root Cause:
Toxins from marine animals cause local or systemic effects, including tissue damage, allergic reactions, and cardiovascular disturbances.
How it's Diagnosed: videos
Clinical history, observation of sting site, identification of the marine animal, and symptom assessment.
Treatment:
Removal of stingers or spines, rinsing with vinegar or hot water, pain management, and supportive care. Antivenom may be used for specific stings (e.g., box jellyfish).
Medications:
Pain Relievers
Prevalence:
How common the health condition is within a specific population.
Common in coastal regions; thousands of cases occur annually worldwide.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Swimming or diving in marine environments, inadequate protective measures (e.g., wetsuits).
Prognosis:
The expected outcome or course of the condition over time.
Excellent with appropriate treatment; severe cases (e.g., box jellyfish stings) require prompt intervention.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Severe allergic reactions, tissue necrosis, infection, and cardiac arrest in rare cases.
Alcohol Withdrawal Syndrome
Specialty: Toxicology
Category: Acute Poisoning
Sub-category: Alcohol-Related Toxicity
Symptoms:
tremors; sweating; anxiety; nausea; vomiting; seizures; hallucinations; delirium tremens
Root Cause:
Sudden cessation or reduction of chronic alcohol consumption leading to central nervous system hyperactivity due to downregulated GABA and upregulated glutamate pathways.
How it's Diagnosed: videos
Clinical history, assessment using tools like the Clinical Institute Withdrawal Assessment for Alcohol (CIWA-Ar) scale, and ruling out other causes of symptoms.
Treatment:
Benzodiazepines (e.g., diazepam, lorazepam), thiamine to prevent Wernicke’s encephalopathy, and supportive care.
Medications:
Diazepam or lorazepam (benzodiazepines) are first-line treatments to control withdrawal symptoms and prevent seizures. Thiamine (vitamin B1) is used to prevent neurological complications.
Prevalence:
How common the health condition is within a specific population.
Occurs in approximately 50% of individuals with chronic alcohol use disorder who suddenly stop drinking. Severe forms (delirium tremens) occur in about 5%.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Chronic alcohol use, history of withdrawal seizures, concurrent illness, electrolyte imbalances, malnutrition.
Prognosis:
The expected outcome or course of the condition over time.
With treatment, symptoms resolve within a few days; untreated severe withdrawal can be life-threatening.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Seizures, delirium tremens, Wernicke-Korsakoff syndrome, arrhythmias, death.
Ovarian Torsion
Specialty: Emergency and Urgent Care
Category: Obstetric and Gynecologic Emergencies
Sub-category: Gynecologic Conditions
Symptoms:
sudden severe pelvic or abdominal pain; nausea; vomiting; abdominal tenderness; fever (occasionally)
Root Cause:
Twisting of the ovary and sometimes the fallopian tube, which compromises blood flow to the ovary. Often associated with ovarian cysts or masses.
How it's Diagnosed: videos
Clinical history, physical exam, transvaginal or pelvic ultrasound with Doppler to assess blood flow to the ovary, and occasionally diagnostic laparoscopy.
Treatment:
Emergency surgical intervention (laparoscopy or laparotomy) to untwist the ovary and preserve ovarian function. In some cases, oophorectomy (removal of the ovary) may be necessary.
Medications:
Pain relief is often managed with analgesics such as NSAIDs or opioids. Post-surgery antibiotics may be used to prevent infection. Examples - Ibuprofen (NSAID), Morphine (opioid), and Ceftriaxone (antibiotic).
Prevalence:
How common the health condition is within a specific population.
Relatively rare; accounts for about 3% of gynecologic emergencies.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Ovarian cysts or tumors, pregnancy, hormonal treatments for ovulation induction, previous ovarian torsion, long ovarian ligaments.
Prognosis:
The expected outcome or course of the condition over time.
Good if treated promptly. Delay in treatment can lead to ovarian necrosis and loss of ovarian function.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Infertility, ovarian necrosis, peritonitis, sepsis, and in severe cases, death.
Esophageal or Gastrointestinal Obstruction
Specialty: Emergency and Urgent Care
Category: Miscellaneous Emergencies
Sub-category: Foreign Body Ingestion/Inhalation
Symptoms:
difficulty swallowing (dysphagia); chest pain; drooling; regurgitation; vomiting; abdominal pain; inability to pass gas or stool (in cases of complete obstruction)
Root Cause:
A blockage in the esophagus or gastrointestinal tract caused by ingested foreign objects, strictures, tumors, or impacted food.
How it's Diagnosed: videos
Clinical history, physical examination, imaging studies (X-ray, CT scan, or ultrasound), endoscopy for direct visualization. Contrast studies may be used in some cases.
Treatment:
Removal of the obstruction via endoscopy, surgery for severe cases, and supportive care such as IV fluids or pain management. If caused by food impaction, smooth muscle relaxants or enzymatic agents may be used.
Medications:
Glucagon - Smooth muscle relaxant to assist with food impaction. Proton pump inhibitors (e.g., omeprazole ) - Reduce acid and prevent mucosal damage in prolonged obstructions. Antiemetics (e.g., ondansetron ) - To control vomiting during treatment.
Prevalence:
How common the health condition is within a specific population.
Common among young children (due to foreign object ingestion) and adults with esophageal disorders such as strictures or motility issues.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Age (young children and elderly), neurological disorders, dental issues, alcohol intoxication, and eating too quickly.
Prognosis:
The expected outcome or course of the condition over time.
Good if treated promptly; delayed intervention can result in perforation, infection, or permanent damage to the gastrointestinal tract.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Perforation, infection (mediastinitis or peritonitis), aspiration pneumonia, esophageal stricture formation, or death in severe cases.
Labyrinthitis (Inner Ear Infection Affecting Hearing and Balance)
Specialty: Ear
Category: Infectious and Inflammatory Ear Conditions
Sub-category: Inner Ear Infections
Symptoms:
vertigo; dizziness; nausea; vomiting; loss of balance; hearing loss; tinnitus (ringing in the ears); difficulty focusing the eyes
Root Cause:
Inflammation or infection of the labyrinth (inner ear), typically due to a viral or bacterial cause, affecting both the vestibular and auditory systems.
How it's Diagnosed: videos
Clinical evaluation based on symptoms and history, physical examination, hearing tests (audiometry), and sometimes imaging studies (MRI or CT) to rule out other causes like stroke.
Treatment:
Rest, hydration, physical therapy for balance (vestibular rehabilitation therapy), and medications to alleviate symptoms. If bacterial, antibiotics may be prescribed.
Medications:
Antihistamines (e.g., meclizine ) for vertigo. Benzodiazepines (e.g., diazepam ) to suppress vestibular symptoms. Antiemetics (e.g., prochlorperazine ) for nausea and vomiting. Corticosteroids (e.g., prednisone ) to reduce inflammation in severe cases. Antibiotics (e.g., amoxicillin ) if a bacterial infection is confirmed.
Prevalence:
How common the health condition is within a specific population.
Common, especially in adults aged 30–60; exact prevalence varies but is more frequent during viral outbreaks (e.g., flu season).
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Recent viral or bacterial infections, respiratory illnesses, weakened immune system, history of ear infections, and smoking.
Prognosis:
The expected outcome or course of the condition over time.
Good for most cases; symptoms usually improve within a few weeks to months. Persistent balance issues or hearing loss can occur in severe cases.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic dizziness, permanent hearing loss, and secondary conditions like anxiety due to prolonged vertigo episodes.
Thyroid Storm (Thyrotoxic Crisis)
Specialty: Diabetes and Endocrinology
Category: Thyroid Disorders
Sub-category: Other Thyroid Disorders
Symptoms:
high fever; rapid heart rate (tachycardia); nervousness or anxiety; tremors; confusion; diarrhea; vomiting; extreme fatigue; shortness of breath
Root Cause:
Severe, life-threatening exacerbation of hyperthyroidism, often triggered by infection, surgery, trauma, or untreated Graves' disease.
How it's Diagnosed: videos
Clinical presentation (severe hyperthyroid symptoms), lab tests showing suppressed TSH and elevated T3/T4 levels, alongside exclusion of other conditions (e.g., sepsis).
Treatment:
Immediate hospitalization, beta-blockers (e.g., propranolol) for symptom control, antithyroid medications (e.g., methimazole or propylthiouracil), iodine to inhibit thyroid hormone release, and corticosteroids to reduce inflammation.
Medications:
Methimazole or propylthiouracil (antithyroid drugs); propranolol (beta-blocker); potassium iodide (iodine preparation ); hydrocortisone (corticosteroid).
Prevalence:
How common the health condition is within a specific population.
Rare, occurring in approximately 1–2% of patients with untreated or poorly managed hyperthyroidism.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Untreated hyperthyroidism, Graves' disease, recent surgery, infection, pregnancy, or iodine exposure.
Prognosis:
The expected outcome or course of the condition over time.
High mortality if untreated (up to 30%); prognosis improves significantly with prompt treatment.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Heart failure, arrhythmias, multiple organ failure, death.
Primary (Addison’s Disease)
Specialty: Diabetes and Endocrinology
Category: Adrenal Disorders
Sub-category: Adrenal Insufficiency
Symptoms:
fatigue; weight loss; muscle weakness; low blood pressure; salt cravings; hyperpigmentation of the skin; nausea; vomiting; abdominal pain; hypoglycemia
Root Cause:
Destruction or dysfunction of the adrenal cortex leads to insufficient production of cortisol and, often, aldosterone.
How it's Diagnosed: videos
Diagnosis involves clinical evaluation, blood tests showing low cortisol and high ACTH levels, and confirmation with an ACTH stimulation test. Electrolyte imbalances (e.g., hyponatremia, hyperkalemia) and low aldosterone may also be observed.
Treatment:
Lifelong hormone replacement therapy with glucocorticoids and mineralocorticoids, stress management, and patient education on managing adrenal crises.
Medications:
Medications include hydrocortisone or prednisone (glucocorticoids) to replace cortisol and fludrocortisone (a mineralocorticoid) to replace aldosterone. These are classified as corticosteroid replacement therapies.
Prevalence:
How common the health condition is within a specific population.
Rare; approximately 1 in 100,000 people are affected, with equal distribution across genders.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Autoimmune diseases (e.g., autoimmune polyendocrine syndrome), infections (e.g., tuberculosis), adrenal hemorrhage, or genetic predisposition.
Prognosis:
The expected outcome or course of the condition over time.
With proper treatment, individuals can live normal lives, but they must manage the risk of adrenal crises, especially during stress or illness.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Adrenal crisis (life-threatening), severe hypotension, electrolyte imbalances, and hypoglycemia.
Secondary Adrenal Insufficiency (e.g., Pituitary Dysfunction)
Specialty: Diabetes and Endocrinology
Category: Adrenal Disorders
Sub-category: Adrenal Insufficiency
Symptoms:
fatigue; muscle weakness; low blood pressure; nausea; vomiting; dizziness; hypoglycemia
Root Cause:
Inadequate production of ACTH by the pituitary gland leads to insufficient stimulation of the adrenal glands, resulting in low cortisol levels.
How it's Diagnosed: videos
Diagnosis involves measuring cortisol and ACTH levels, as well as dynamic testing (e.g., ACTH stimulation test, insulin tolerance test). Brain imaging (MRI) may be used to identify pituitary abnormalities.
Treatment:
Glucocorticoid replacement therapy and, if applicable, addressing the underlying cause (e.g., pituitary tumor or discontinuation of long-term corticosteroid use).
Medications:
Medications include hydrocortisone or prednisone to replace cortisol. These are classified as glucocorticoid replacement therapies.
Prevalence:
How common the health condition is within a specific population.
More common than primary adrenal insufficiency; often associated with prolonged corticosteroid use or pituitary dysfunction. Exact prevalence is unclear but estimated to be higher than Addison's disease.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Long-term corticosteroid use, pituitary tumors, traumatic brain injury, or radiation therapy to the brain.
Prognosis:
The expected outcome or course of the condition over time.
Generally favorable with treatment, but adrenal crises may occur during stress or illness if glucocorticoid dosing is not increased.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Adrenal crisis, persistent fatigue, hypoglycemia, and dependence on hormone replacement therapy.
Hypermagnesemia
Specialty: Nephrology
Category: Electrolyte and Acid-Base Disorders
Symptoms:
nausea; vomiting; weakness; hypotension; respiratory depression; bradycardia; lethargy; decreased deep tendon reflexes; cardiac arrest in severe cases
Root Cause:
Excess magnesium in the blood, often due to impaired kidney function, excessive magnesium intake, or use of magnesium-containing medications.
How it's Diagnosed: videos
Blood tests to measure serum magnesium levels, alongside kidney function tests and electrolyte panels.
Treatment:
Discontinuation of magnesium-containing products, intravenous calcium gluconate (to stabilize cardiac membranes), diuretics to promote magnesium excretion, and dialysis in severe cases.
Medications:
Calcium gluconate (calcium supplement and cardioprotective agent), diuretics such as furosemide (loop diuretic).
Prevalence:
How common the health condition is within a specific population.
Rare in the general population; more common in individuals with chronic kidney disease or excessive magnesium intake.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Renal failure, use of magnesium-containing antacids or laxatives, and intravenous magnesium therapy.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with prompt treatment, but severe cases can lead to life-threatening complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Cardiac arrest, respiratory failure, and neuromuscular dysfunction.
Hypomagnesemia
Specialty: Nephrology
Category: Electrolyte and Acid-Base Disorders
Symptoms:
muscle cramps; tremors; weakness; fatigue; nausea; vomiting; irritability; confusion; seizures; cardiac arrhythmias (e.g., prolonged qt interval)
Root Cause:
Low magnesium levels in the blood due to inadequate dietary intake, increased excretion via kidneys or gastrointestinal tract, or certain medications.
How it's Diagnosed: videos
Blood tests measuring serum magnesium levels; additional evaluations may include kidney function tests and assessment of other electrolytes (e.g., calcium and potassium).
Treatment:
Address underlying causes, magnesium supplementation (oral or intravenous), and correction of associated electrolyte imbalances.
Medications:
Magnesium supplements, such as magnesium oxide (oral) or magnesium sulfate (IV for severe cases). These are electrolyte supplements.
Prevalence:
How common the health condition is within a specific population.
Common in hospitalized patients (up to 10%–20%) and in individuals with chronic illnesses.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Chronic alcoholism, malnutrition, gastrointestinal disorders (e.g., Crohn’s disease), diuretics, proton pump inhibitors, and diabetes.
Prognosis:
The expected outcome or course of the condition over time.
Generally good with timely diagnosis and treatment, but prolonged or severe cases can lead to significant complications if untreated.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Cardiac arrhythmias, seizures, muscle paralysis, and refractory hypocalcemia or hypokalemia.
Esophagitis
Specialty: Gastrointestinal
Category: Esophageal Disorders
Sub-category: Inflammatory and Infectious Disorders
Symptoms:
pain or difficulty swallowing; chest pain; heartburn; regurgitation; nausea; vomiting; sore throat
Root Cause:
Inflammation of the esophageal lining caused by acid reflux, infections, medications, or allergies.
How it's Diagnosed: videos
Endoscopy with biopsy, barium swallow studies, and laboratory tests for infectious causes.
Treatment:
Addressing the underlying cause, acid suppression therapy, treating infections with appropriate medications, and dietary modifications.
Medications:
Proton pump inhibitors (PPIs) like pantoprazole for acid suppression; antifungals like fluconazole for fungal infections; antivirals like acyclovir for herpes esophagitis; corticosteroids for eosinophilic esophagitis.
Prevalence:
How common the health condition is within a specific population.
Common; varies depending on the underlying cause (e.g., GERD-related esophagitis affects millions).
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
GERD, immunosuppression, prolonged medication use, food allergies, and certain infections.
Prognosis:
The expected outcome or course of the condition over time.
Generally good with appropriate treatment; untreated cases can lead to complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Strictures, ulcers, bleeding, and perforation in severe cases.
Gastritis (Acute and Chronic)
Specialty: Gastrointestinal
Category: Stomach Disorders
Sub-category: Inflammatory Disorders
Symptoms:
abdominal pain; nausea; vomiting; loss of appetite; bloating; belching; indigestion; dark stools (if bleeding occurs)
Root Cause:
Inflammation of the stomach lining caused by factors such as Helicobacter pylori infection, excessive alcohol consumption, NSAID use, or autoimmune disorders.
How it's Diagnosed: videos
Through patient history, physical examination, endoscopy with biopsy, and testing for H. pylori (urea breath test, stool antigen test, or blood antibody test).
Treatment:
Addressing the underlying cause (e.g., H. pylori eradication, reducing NSAID use), lifestyle modifications, and symptomatic relief.
Medications:
Proton pump inhibitors (PPIs) like omeprazole or lansoprazole to reduce stomach acid. H2-receptor antagonists such as ranitidine or famotidine to reduce acid production. Antibiotics (if H. pylori is present) like amoxicillin , clarithromycin , and metronidazole for bacterial eradication. Antacids for temporary relief of symptoms.
Prevalence:
How common the health condition is within a specific population.
Common worldwide; chronic gastritis is prevalent in up to 50% of the global population, with higher rates in developing countries due to H. pylori.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Chronic H. pylori infection, long-term NSAID use, excessive alcohol intake, smoking, stress, autoimmune conditions, older age.
Prognosis:
The expected outcome or course of the condition over time.
Good with appropriate treatment; acute cases often resolve quickly, while chronic cases require ongoing management to prevent complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Peptic ulcers, gastric bleeding, anemia, increased risk of gastric cancer (especially in chronic cases linked to H. pylori).
Gastroparesis (Delayed Gastric Emptying)
Specialty: Gastrointestinal
Category: Stomach Disorders
Sub-category: Structural and Functional Disorders
Symptoms:
nausea; vomiting; bloating; early satiety; abdominal pain; unintentional weight loss; heartburn
Root Cause:
Impaired motility of the stomach muscles prevents proper emptying of stomach contents into the small intestine, often associated with vagus nerve damage or autonomic dysfunction.
How it's Diagnosed: videos
Diagnosed through gastric emptying studies (scintigraphy), upper gastrointestinal (GI) endoscopy to rule out obstruction, and breath tests (e.g., carbon-labeled meal breath test).
Treatment:
Dietary changes (small, low-fat meals), medications to improve gastric motility, and in severe cases, gastric electrical stimulation or feeding tubes.
Medications:
Metoclopramide (dopamine antagonist) is often prescribed to improve stomach contractions. Domperidone (dopamine antagonist) is another option available in some regions. Erythromycin (macrolide antibiotic) can enhance gastric motility as a side effect. Antiemetics such as ondansetron or promethazine may be used to manage nausea.
Prevalence:
How common the health condition is within a specific population.
Affects approximately 0.2% of the general population; higher prevalence among individuals with diabetes or post-surgical complications.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Diabetes mellitus, prior gastric surgery, systemic diseases like scleroderma, infections, and certain medications (e.g., opioids, anticholinergics).
Prognosis:
The expected outcome or course of the condition over time.
Varies; many cases improve with dietary changes and medications, but severe cases may lead to malnutrition and require surgical interventions.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Malnutrition, dehydration, bezoars (hardened masses of undigested food), and severe weight loss.
Gastric Ulcers
Specialty: Gastrointestinal
Category: Stomach Disorders
Sub-category: Peptic Ulcer Disease
Symptoms:
burning or gnawing pain in the stomach; bloating; nausea; vomiting; loss of appetite; unexplained weight loss; dark or black stools (indicating bleeding); vomiting blood or coffee-ground-like material
Root Cause:
Gastric ulcers are sores that develop on the stomach lining due to the breakdown of the protective mucosal layer, often caused by Helicobacter pylori infection or the prolonged use of NSAIDs.
How it's Diagnosed: videos
Endoscopy (esophagogastroduodenoscopy), biopsy during endoscopy to check for H. pylori, urea breath test, stool antigen test, and blood tests for anemia.
Treatment:
Eradication of H. pylori infection if present, reduction of stomach acid production, lifestyle modifications (dietary changes, smoking cessation), and avoidance of NSAIDs.
Medications:
Proton pump inhibitors (PPIs) like omeprazole , pantoprazole , or esomeprazole reduce stomach acid production. H2 receptor blockers such as ranitidine or famotidine are used for acid reduction. Antibiotics like clarithromycin , amoxicillin , and metronidazole for H. pylori eradication. Antacids and cytoprotective agents like sucralfate or bismuth subsalicylate to protect the stomach lining.
Prevalence:
How common the health condition is within a specific population.
Gastric ulcers affect approximately 5-10% of the global population during their lifetime, with higher rates in individuals over 60 years of age.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
H. pylori infection, chronic NSAID use, smoking, alcohol consumption, high-stress levels, and a family history of peptic ulcers.
Prognosis:
The expected outcome or course of the condition over time.
With appropriate treatment, most gastric ulcers heal within 6-8 weeks. Eradicating H. pylori significantly reduces the recurrence rate.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Bleeding, perforation of the stomach wall, penetration into adjacent organs, gastric outlet obstruction, and increased risk of stomach cancer.
Duodenal Ulcers
Specialty: Gastrointestinal
Category: Stomach Disorders
Sub-category: Peptic Ulcer Disease
Symptoms:
burning stomach pain that improves with eating or drinking; bloating; belching; nausea; vomiting; loss of appetite; unexplained weight loss; dark or tarry stools; vomiting blood or material resembling coffee grounds
Root Cause:
Duodenal ulcers are sores in the lining of the first part of the small intestine, commonly caused by H. pylori infection or chronic NSAID use, leading to acid-related damage.
How it's Diagnosed: videos
Endoscopy, urea breath test, stool antigen test, and biopsy for H. pylori detection; blood tests may also identify anemia associated with bleeding ulcers.
Treatment:
Treatment involves acid suppression, eradication of H. pylori, lifestyle changes, and avoiding irritants like NSAIDs.
Medications:
Proton pump inhibitors (PPIs) such as omeprazole or lansoprazole reduce acid secretion. Antibiotics like clarithromycin , amoxicillin , and metronidazole are used to treat H. pylori infection. H2 receptor blockers such as ranitidine or famotidine provide acid reduction. Cytoprotective agents like sucralfate and bismuth subsalicylate enhance mucosal protection.
Prevalence:
How common the health condition is within a specific population.
Duodenal ulcers are more common than gastric ulcers, with a lifetime prevalence of approximately 10-15%, particularly among younger adults and males.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
H. pylori infection, NSAID use, smoking, high-stress levels, excessive alcohol consumption, and a family history of peptic ulcers.
Prognosis:
The expected outcome or course of the condition over time.
Most duodenal ulcers heal within 4-6 weeks with appropriate treatment. H. pylori eradication substantially reduces recurrence.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Bleeding, perforation, penetration into adjacent organs, duodenal obstruction, and rarely an increased risk of cancer in the duodenum.
Gastric Adenocarcinoma
Specialty: Gastrointestinal
Category: Stomach Disorders
Sub-category: Stomach Cancer
Symptoms:
abdominal pain; unexplained weight loss; nausea; vomiting; loss of appetite; early satiety; blood in stool; fatigue
Root Cause:
Malignant transformation of the gastric mucosal cells, often associated with chronic inflammation, H. pylori infection, genetic predisposition, or dietary carcinogens.
How it's Diagnosed: videos
Endoscopy with biopsy, imaging studies (CT scan, MRI, PET), blood tests for tumor markers (e.g., CEA, CA 19-9), and staging procedures.
Treatment:
Surgical resection (gastrectomy), chemotherapy, radiation therapy, targeted therapy (e.g., HER2 inhibitors for HER2-positive tumors).
Medications:
Treatment may include chemotherapy drugs such as 5-fluorouracil (5-FU) (antimetabolite), cisplatin (platinum-based alkylating agent), and trastuzumab (HER2-targeted monoclonal antibody) for HER2-positive cases.
Prevalence:
How common the health condition is within a specific population.
One of the most common types of stomach cancer, with higher rates in East Asia, Eastern Europe, and South America.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
H. pylori infection, smoking, high salt intake, diet low in fruits and vegetables, chronic gastritis, family history of gastric cancer, genetic syndromes (e.g., Lynch syndrome).
Prognosis:
The expected outcome or course of the condition over time.
Prognosis depends on the stage at diagnosis; early detection improves survival rates significantly, but advanced cases have poorer outcomes.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Metastasis to other organs (liver, lungs, peritoneum), gastrointestinal bleeding, obstruction, and malnutrition.
Gastrointestinal Stromal Tumors (GISTs)
Specialty: Gastrointestinal
Category: Stomach Disorders
Sub-category: Stomach Tumors
Symptoms:
abdominal pain; gastrointestinal bleeding; early satiety; nausea; vomiting; unexplained weight loss
Root Cause:
Tumors arising from the interstitial cells of Cajal in the gastrointestinal tract, often due to mutations in the KIT or PDGFRA genes.
How it's Diagnosed: videos
Endoscopy, biopsy with immunohistochemistry (testing for KIT/CD117 positivity), CT scan, MRI, and PET scan for staging.
Treatment:
Surgical resection for localized tumors, tyrosine kinase inhibitors (TKIs) like imatinib for advanced or metastatic cases.
Medications:
Imatinib (a tyrosine kinase inhibitor) is the first-line treatment for advanced or metastatic GISTs. Other options include sunitinib and regorafenib for imatinib-resistant cases.
Prevalence:
How common the health condition is within a specific population.
Relatively rare, accounting for less than 1% of gastrointestinal cancers, with a higher incidence in adults over 50.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Family history of GISTs, genetic mutations, age over 50, and association with neurofibromatosis type 1 (NF1).
Prognosis:
The expected outcome or course of the condition over time.
Excellent prognosis for localized GISTs treated surgically; variable outcomes for advanced cases depending on response to TKI therapy.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Tumor rupture, peritoneal spread, liver metastases, and gastrointestinal obstruction or perforation.
Lymphoma of the Stomach
Specialty: Gastrointestinal
Category: Stomach Disorders
Sub-category: Stomach Lymphomas
Symptoms:
abdominal pain; bloating; weight loss; nausea; vomiting; fatigue; fever; night sweats; loss of appetite
Root Cause:
Malignant proliferation of lymphoid tissue in the stomach, often linked to chronic H. pylori infection or immune suppression.
How it's Diagnosed: videos
Endoscopy with biopsy, histopathology, immunohistochemistry, imaging (CT, PET scan), and bone marrow biopsy for staging.
Treatment:
Eradication of H. pylori with antibiotics if associated, chemotherapy, radiation therapy, immunotherapy (e.g., rituximab), or a combination depending on the lymphoma type.
Medications:
Antibiotics (for H. pylori-associated cases, e.g., amoxicillin and clarithromycin ), rituximab (CD20 monoclonal antibody), and chemotherapy agents like cyclophosphamide , doxorubicin , vincristine , and prednisone (CHOP regimen).
Prevalence:
How common the health condition is within a specific population.
Represents less than 5% of all stomach cancers, with a higher prevalence in individuals with chronic H. pylori infection.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
H. pylori infection, autoimmune disorders, immunosuppression, and family history of lymphoma.
Prognosis:
The expected outcome or course of the condition over time.
Varies by type and stage; early-stage cases have a good prognosis, particularly with H. pylori eradication, while advanced cases depend on response to chemotherapy.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Gastrointestinal bleeding, obstruction, perforation, and spread to lymph nodes or other organs.
Zollinger-Ellison Syndrome (Gastrinoma)
Specialty: Gastrointestinal
Category: Other Stomach Conditions
Sub-category: Stomach Cancer
Symptoms:
abdominal pain; diarrhea; nausea; vomiting; weight loss; heartburn; gastric ulcers; gastrointestinal bleeding
Root Cause:
Excessive secretion of gastrin due to a gastrin-secreting tumor (gastrinoma), leading to increased stomach acid production.
How it's Diagnosed: videos
Blood tests to measure gastrin levels, secretin stimulation test, imaging studies (CT, MRI, or somatostatin receptor scintigraphy) to locate gastrinoma, and endoscopic examination.
Treatment:
Proton pump inhibitors (PPIs) to reduce acid production, surgical removal of the gastrinoma, and chemotherapy or targeted therapy for metastatic disease.
Medications:
Proton pump inhibitors (e.g., omeprazole or esomeprazole ) to reduce gastric acid secretion; somatostatin analogs (e.g., octreotide ) to inhibit gastrin release; chemotherapeutic agents (e.g., streptozocin and doxorubicin ) for advanced cases.
Prevalence:
How common the health condition is within a specific population.
Rare; occurs in approximately 1–3 individuals per million annually.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Associated with multiple endocrine neoplasia type 1 (MEN1), family history of endocrine tumors.
Prognosis:
The expected outcome or course of the condition over time.
Varies; curable if localized gastrinoma is surgically removed, but prognosis worsens with metastatic disease.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Peptic ulcers, perforation of the stomach or intestines, gastrointestinal bleeding, severe diarrhea, and malnutrition.
Menetrier’s Disease (Hypertrophic Gastropathy)
Specialty: Gastrointestinal
Category: Other Stomach Conditions
Sub-category: Stomach Cancer
Symptoms:
nausea; vomiting; epigastric pain; diarrhea; anorexia; weight loss; edema due to protein loss
Root Cause:
Overgrowth of the stomach’s mucosal lining, leading to large gastric folds, protein loss, and reduced acid production.
How it's Diagnosed: videos
Endoscopy with biopsy of stomach tissue, barium swallow test, serum albumin levels to assess protein loss, and imaging to identify gastric wall thickening.
Treatment:
Symptomatic management, nutritional support, proton pump inhibitors, and sometimes total gastrectomy in severe cases.
Medications:
Proton pump inhibitors (e.g., pantoprazole or lansoprazole ) to reduce gastric secretion; cetuximab , a monoclonal antibody targeting epidermal growth factor receptor (EGFR), has shown promise in some cases.
Prevalence:
How common the health condition is within a specific population.
Extremely rare; incidence is not well-documented.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Unknown, though some cases are linked to cytomegalovirus (CMV) infection in children or H. pylori infection in adults.
Prognosis:
The expected outcome or course of the condition over time.
Variable; some cases resolve spontaneously, while others progress and require surgical intervention.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Severe protein loss leading to hypoalbuminemia, gastric adenocarcinoma, malnutrition, and fluid retention (edema).
Intussusception
Specialty: Gastrointestinal
Category: Small Intestine Disorders
Sub-category: Structural Disorders
Symptoms:
sudden severe abdominal pain; vomiting; red jelly-like stools; lethargy; abdominal swelling
Root Cause:
Telescoping of one part of the intestine into another, leading to obstruction and compromised blood supply.
How it's Diagnosed: videos
Ultrasound showing a “target” or “doughnut” sign, abdominal X-ray, or CT scan; confirmed during surgery if imaging is inconclusive.
Treatment:
Air or barium enema reduction is often diagnostic and therapeutic; surgery is indicated if enema reduction fails or if complications are suspected.
Medications:
Pain relief with acetaminophen or ibuprofen , and antibiotics (e.g., ampicillin , cefotaxime ) postoperatively to prevent infection.
Prevalence:
How common the health condition is within a specific population.
Most common cause of intestinal obstruction in children under 3 years, with an incidence of 1–4 cases per 1,000 live births.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Male sex, viral infections, Meckel’s diverticulum, intestinal polyps, or lymphoid hyperplasia.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with prompt diagnosis and treatment; recurrence occurs in 5–10% of cases.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Bowel necrosis, perforation, peritonitis, and sepsis.
Small Bowel Adenocarcinoma
Specialty: Gastrointestinal
Category: Small Intestine Disorders
Sub-category: Tumors
Symptoms:
abdominal pain; nausea; vomiting; unexplained weight loss; intestinal obstruction; anemia; blood in stool
Root Cause:
Uncontrolled growth of malignant epithelial cells originating in the small intestine, often due to genetic mutations or chronic inflammation.
How it's Diagnosed: videos
Imaging studies (CT scans, MRI, PET scans), endoscopy, biopsy, blood tests (including tumor markers like CEA or CA19-9).
Treatment:
Surgery to remove the tumor, chemotherapy, and in some cases, targeted therapy.
Medications:
Chemotherapy drugs such as 5-fluorouracil (antimetabolite), oxaliplatin (platinum-based agent), or capecitabine (oral antimetabolite). Targeted therapies like pembrolizumab (immune checkpoint inhibitor) may also be used.
Prevalence:
How common the health condition is within a specific population.
Rare, accounting for approximately 3-5% of gastrointestinal cancers and less than 1% of all cancers.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Family history of gastrointestinal cancers, genetic syndromes (e.g., Lynch syndrome, familial adenomatous polyposis), chronic inflammation (e.g., Crohn’s disease), and diet high in red or processed meat.
Prognosis:
The expected outcome or course of the condition over time.
Varies by stage; localized tumors have a better prognosis (5-year survival rate ~65%), while advanced/metastatic disease has a poor prognosis (~10-20% 5-year survival).
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Intestinal obstruction, perforation, metastasis to the liver or lymph nodes, and paraneoplastic syndromes.
Infectious Colitis (e.g., Viral, Bacterial, Parasitic)
Specialty: Gastrointestinal
Category: Large Intestine (Colon) Disorders
Sub-category: Infectious Disorders
Symptoms:
diarrhea (often with blood or mucus); abdominal pain; fever; nausea; vomiting; fatigue; dehydration; weight loss
Root Cause:
Infection of the colon by pathogens such as bacteria (e.g., Salmonella, Shigella, E. coli, Campylobacter), viruses (e.g., norovirus, rotavirus), or parasites (e.g., Entamoeba histolytica, Giardia). This leads to inflammation and damage to the intestinal lining.
How it's Diagnosed: videos
Stool tests for pathogens (culture, PCR, or antigen detection), blood tests for inflammatory markers, and colonoscopy in chronic or severe cases to assess mucosal damage.
Treatment:
Supportive care (hydration, electrolyte replacement) and pathogen-specific treatment. Antibiotics for bacterial infections, antiparasitic medications for parasitic infections, and sometimes antiviral therapy for severe viral infections.
Medications:
Antibiotics like ciprofloxacin or azithromycin for bacterial infections; metronidazole or tinidazole for parasitic infections like Giardia or Entamoeba; oral rehydration salts for dehydration. Antibiotics are categorized as antimicrobials, while antiparasitic drugs target protozoa.
Prevalence:
How common the health condition is within a specific population.
Infectious colitis is a common cause of diarrhea worldwide, with bacterial pathogens accounting for 85% of foodborne outbreaks in developed countries.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Contaminated food or water, international travel, poor hygiene, immunosuppression, and exposure to infected individuals.
Prognosis:
The expected outcome or course of the condition over time.
Most cases resolve within days to weeks with appropriate treatment, but severe infections can lead to prolonged illness or death, particularly in vulnerable populations.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Dehydration, electrolyte imbalances, hemolytic uremic syndrome (HUS, associated with E. coli O157:H7), chronic post-infectious irritable bowel syndrome, and intestinal perforation.
Viral Hepatitis (A, B, C, D, E)
Specialty: Gastrointestinal
Category: Liver Disorders
Sub-category: Hepatitis
Symptoms:
jaundice; fatigue; abdominal pain; nausea; vomiting; loss of appetite; dark urine; pale stools
Root Cause:
Infection of the liver caused by hepatitis viruses (A, B, C, D, or E), leading to liver inflammation and, in some cases, chronic liver disease.
How it's Diagnosed: videos
Blood tests to identify viral markers (e.g., HBsAg, anti-HCV, anti-HAV), liver function tests, imaging studies like ultrasound, and sometimes liver biopsy.
Treatment:
Treatment depends on the type of hepatitis. Includes antiviral medications, supportive care (hydration, rest), and, in severe cases, liver transplantation.
Medications:
Hepatitis B - Tenofovir (antiviral, nucleotide analog), Entecavir (antiviral, nucleoside analog). Hepatitis C - Sofosbuvir and Velpatasvir (direct-acting antiviral agents). Hepatitis A & E - No specific antiviral treatment; supportive care. Hepatitis D - Pegylated interferon-alpha (antiviral, immune modulator).
Prevalence:
How common the health condition is within a specific population.
Affects millions globally; Hepatitis B and C are the most common chronic forms, with over 250 million and 70 million people affected worldwide, respectively.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Unprotected sex, intravenous drug use, sharing needles, blood transfusions, close contact with infected individuals, and poor sanitation.
Prognosis:
The expected outcome or course of the condition over time.
Acute hepatitis often resolves with supportive care, but chronic hepatitis (especially B and C) can lead to cirrhosis, liver failure, or hepatocellular carcinoma if untreated.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic liver disease, cirrhosis, liver cancer, and liver failure.
Alcoholic Hepatitis
Specialty: Infectious Diseases
Category: Gastrointestinal Tract and Intra-abdominal Infections
Symptoms:
jaundice; abdominal pain; nausea; vomiting; fever; weight loss; fatigue; anorexia
Root Cause:
Inflammation and liver cell damage caused by prolonged and excessive alcohol consumption leading to toxic metabolites.
How it's Diagnosed: videos
Clinical history of alcohol use, physical examination, liver function tests (elevated AST, ALT, and bilirubin levels), imaging (ultrasound/CT), and sometimes liver biopsy.
Treatment:
Cessation of alcohol, nutritional support, corticosteroids (for severe cases), and addressing complications like infections or ascites.
Medications:
Medications include corticosteroids (e.g., prednisolone ), which reduce inflammation; pentoxifylline , a phosphodiesterase inhibitor that may prevent complications like hepatorenal syndrome. Vitamin supplementation (e.g., thiamine and folate) is often provided for nutritional deficiencies.
Prevalence:
How common the health condition is within a specific population.
Alcoholic hepatitis is most common in individuals with a history of chronic alcohol use, with a prevalence of approximately 1–2% of heavy drinkers annually.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Chronic heavy alcohol consumption, malnutrition, genetic predisposition, female gender (higher susceptibility), obesity, and prior liver disease.
Prognosis:
The expected outcome or course of the condition over time.
Varies with severity; mild cases may recover with alcohol cessation, while severe cases have a high mortality rate without intervention.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Liver cirrhosis, portal hypertension, ascites, hepatic encephalopathy, and increased risk of infections.
Budd-Chiari Syndrome
Specialty: Gastrointestinal
Category: Liver Disorders
Sub-category: Vascular Liver Disorders
Symptoms:
abdominal pain, especially in the upper right quadrant; ascites; enlarged liver (hepatomegaly); jaundice; nausea; vomiting; swelling in the legs; fatigue
Root Cause:
Obstruction of the hepatic veins, often caused by thrombosis or compression, leading to impaired blood flow out of the liver and subsequent congestion and damage.
How it's Diagnosed: videos
Doppler ultrasound, CT scan, MRI, liver biopsy (in some cases), and blood tests to identify hypercoagulable states.
Treatment:
Addressing the underlying cause (e.g., anticoagulation for thrombosis, thrombolysis), managing complications like ascites, and restoring venous outflow via angioplasty, TIPS, or surgical shunting. Liver transplantation may be needed in severe cases.
Medications:
Anticoagulants (e.g., warfarin , heparin ) to prevent further clot formation; diuretics (e.g., spironolactone , furosemide ) for managing ascites; thrombolytic agents (e.g., tissue plasminogen activator) in selected cases.
Prevalence:
How common the health condition is within a specific population.
Rare, with an estimated incidence of 1 in 100,000; more common in patients with underlying hypercoagulable conditions.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Hypercoagulable states (e.g., protein C or S deficiency, antiphospholipid syndrome), polycythemia vera, myeloproliferative disorders, oral contraceptive use, pregnancy, and liver tumors.
Prognosis:
The expected outcome or course of the condition over time.
Variable, depending on the extent of liver damage and the success of treatment. Early intervention can significantly improve outcomes, but severe or untreated cases may lead to liver failure.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Liver failure, portal hypertension, ascites, hepatic encephalopathy, and death in advanced or untreated cases.
Cholelithiasis (Gallstones)
Specialty: Gastrointestinal
Category: Gallbladder and Biliary Tract Disorders
Sub-category: Gallbladder Diseases
Symptoms:
right upper abdominal pain; nausea; vomiting; jaundice; pain after fatty meals
Root Cause:
Formation of solid particles (gallstones) in the gallbladder due to an imbalance in bile components, including cholesterol, bile salts, and bilirubin.
How it's Diagnosed: videos
Abdominal ultrasound, blood tests for liver function, and imaging like CT or MRI when complications are suspected.
Treatment:
Watchful waiting for asymptomatic cases, cholecystectomy (surgical removal of the gallbladder) for symptomatic cases, or non-surgical options like oral bile acid therapy or extracorporeal shockwave lithotripsy.
Medications:
Ursodeoxycholic acid (ursodiol ) can be prescribed; it is a bile acid therapy that helps dissolve cholesterol gallstones over time.
Prevalence:
How common the health condition is within a specific population.
Affects 10–15% of the adult population in developed countries; more common in women and older adults.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Female gender, obesity, rapid weight loss, high-fat diet, pregnancy, and family history.
Prognosis:
The expected outcome or course of the condition over time.
Good with treatment; asymptomatic gallstones may never cause issues, while symptomatic cases resolve after gallbladder removal.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Acute cholecystitis, pancreatitis, bile duct obstruction, and gallbladder cancer in rare cases.
Cholecystitis (Inflammation of the Gallbladder)
Specialty: Gastrointestinal
Category: Gallbladder and Biliary Tract Disorders
Sub-category: Gallbladder Diseases
Symptoms:
severe upper abdominal pain; fever; nausea; vomiting; tenderness in the right upper abdomen
Root Cause:
Inflammation of the gallbladder, usually caused by gallstones blocking the cystic duct, leading to bile stasis and bacterial infection.
How it's Diagnosed: videos
Physical examination, abdominal ultrasound, blood tests indicating inflammation (e.g., elevated WBC, CRP), and imaging like HIDA scan.
Treatment:
Intravenous fluids, antibiotics for infection, pain management, and cholecystectomy (urgent or delayed based on severity).
Medications:
Antibiotics like ceftriaxone (a cephalosporin) combined with metronidazole (an anaerobic antibiotic) to treat infection. Pain management may include NSAIDs or opioids.
Prevalence:
How common the health condition is within a specific population.
Common among individuals with gallstones; prevalence increases with age and in women.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Gallstones, obesity, older age, female gender, and prior episodes of biliary colic.
Prognosis:
The expected outcome or course of the condition over time.
Favorable with treatment; untreated cases can lead to severe complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Gallbladder rupture, sepsis, emphysematous cholecystitis, and biliary peritonitis.
Acalculous Cholecystitis
Specialty: Gastrointestinal
Category: Gallbladder and Biliary Tract Disorders
Sub-category: Gallbladder Diseases
Symptoms:
right upper abdominal pain; fever; nausea; vomiting; jaundice
Root Cause:
Inflammation of the gallbladder without gallstones, often caused by critical illness, ischemia, or infection.
How it's Diagnosed: videos
Ultrasound showing gallbladder wall thickening, pericholecystic fluid, or positive HIDA scan; lab findings may show elevated liver enzymes and WBCs.
Treatment:
Supportive care with IV fluids, broad-spectrum antibiotics, and cholecystectomy or percutaneous cholecystostomy if the condition does not resolve.
Medications:
Broad-spectrum antibiotics like piperacillin-tazobactam (a beta-lactam/beta-lactamase inhibitor) to cover potential infections.
Prevalence:
How common the health condition is within a specific population.
Accounts for 5–10% of all cholecystitis cases; more common in critically ill patients.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Major surgery, trauma, burns, prolonged fasting, total parenteral nutrition (TPN), and sepsis.
Prognosis:
The expected outcome or course of the condition over time.
Variable; outcomes depend on underlying conditions and timely intervention.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Gallbladder gangrene, perforation, abscess formation, and systemic sepsis.
Choledocholithiasis (Bile Duct Stones)
Specialty: Gastrointestinal
Category: Gallbladder and Biliary Tract Disorders
Sub-category: Biliary Tract Disorders
Symptoms:
right upper quadrant abdominal pain; jaundice; dark urine; pale stools; nausea; vomiting; fever (if cholangitis develops)
Root Cause:
Obstruction of the bile duct by gallstones, leading to impaired bile flow.
How it's Diagnosed: videos
Blood tests (elevated bilirubin, alkaline phosphatase, and liver enzymes); imaging studies like ultrasound, MRCP (magnetic resonance cholangiopancreatography), or ERCP (endoscopic retrograde cholangiopancreatography).
Treatment:
ERCP to remove stones; in some cases, surgery or lithotripsy may be needed.
Medications:
Pain relievers (NSAIDs like ibuprofen or opioids like morphine ), antibiotics if infection is present (e.g., ciprofloxacin or metronidazole ).
Prevalence:
How common the health condition is within a specific population.
Approximately 10-20% of individuals with gallstones develop bile duct stones.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
History of gallstones, older age, obesity, rapid weight loss, female sex, family history.
Prognosis:
The expected outcome or course of the condition over time.
Good with timely treatment; recurrence may occur without addressing risk factors.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Cholangitis, pancreatitis, bile duct strictures, liver abscesses.
Cholangitis (Infection of the Bile Ducts)
Specialty: Gastrointestinal
Category: Gallbladder and Biliary Tract Disorders
Sub-category: Biliary Tract Disorders
Symptoms:
fever; chills; right upper quadrant abdominal pain; jaundice; dark urine; nausea; vomiting; hypotension (in severe cases)
Root Cause:
Bacterial infection due to bile duct obstruction, typically caused by stones, strictures, or tumors.
How it's Diagnosed: videos
Diagnosed through clinical signs (Charcot's triad), elevated liver function tests, imaging like ultrasound or MRCP, and sometimes blood cultures to confirm infection.
Treatment:
ERCP to relieve obstruction; broad-spectrum antibiotics (e.g., piperacillin-tazobactam, ceftriaxone, metronidazole).
Medications:
Broad-spectrum antibiotics, typically from the penicillin or cephalosporin family, combined with anti-anaerobic agents (e.g., metronidazole ); antipyretics like acetaminophen .
Prevalence:
How common the health condition is within a specific population.
More common in individuals with a history of gallstones; incidence is 0.3-1.6 per 1,000 hospital admissions.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Gallstones, bile duct strictures, history of bile duct surgery, endoscopic procedures, malignancy.
Prognosis:
The expected outcome or course of the condition over time.
Good with early intervention; mortality is high in untreated cases or septic shock.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Sepsis, liver abscesses, recurrent infections, secondary biliary cirrhosis.
Gallstone Pancreatitis
Specialty: Gastrointestinal
Category: Gallbladder and Biliary Tract Disorders
Sub-category: Acute and Chronic Pancreatitis
Symptoms:
severe upper abdominal pain; nausea; vomiting; fever; jaundice; pain radiating to the back
Root Cause:
Gallstones block the bile duct or pancreatic duct, causing inflammation of the pancreas.
How it's Diagnosed: videos
Blood tests (elevated lipase and amylase levels), abdominal ultrasound, CT scan, or MRCP (magnetic resonance cholangiopancreatography).
Treatment:
Hospitalization, fasting (to rest the pancreas), IV fluids, pain management, antibiotics (if infection is present), and ERCP (endoscopic retrograde cholangiopancreatography) to remove gallstones. Surgery (cholecystectomy) is performed later to prevent recurrence.
Medications:
Pain relievers (opioids like morphine or hydromorphone ), antispasmodics, and antibiotics such as piperacillin-tazobactam or ceftriaxone with metronidazole if infection is suspected.
Prevalence:
How common the health condition is within a specific population.
Most common in adults with gallstones, accounting for 35–40% of acute pancreatitis cases in the U.S.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Gallstones, obesity, female sex, older age, rapid weight loss, high-fat diet.
Prognosis:
The expected outcome or course of the condition over time.
Good with timely treatment; recurrence is prevented with gallstone removal. Mortality risk increases with severe or untreated cases.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Pancreatic necrosis, infection, pseudocysts, organ failure, or systemic inflammatory response syndrome (SIRS).
Alcohol-Induced Pancreatitis
Specialty: Gastrointestinal
Category: Gallbladder and Biliary Tract Disorders
Sub-category: Acute and Chronic Pancreatitis
Symptoms:
severe abdominal pain; pain radiating to the back; nausea; vomiting; weight loss; diarrhea; steatorrhea (fatty stools)
Root Cause:
Chronic alcohol consumption leads to inflammation, scarring, and dysfunction of the pancreas.
How it's Diagnosed: videos
History of alcohol use, blood tests (elevated lipase and amylase levels), imaging (CT, MRI, or ultrasound), and stool tests for fat malabsorption.
Treatment:
Abstinence from alcohol, supportive care with IV fluids, pain management, enzyme replacement therapy, nutritional support, and addressing complications.
Medications:
Pancreatic enzyme supplements (e.g., pancrelipase ), pain relievers (e.g., acetaminophen or opioids for severe cases), proton pump inhibitors (to reduce gastric acid).
Prevalence:
How common the health condition is within a specific population.
Alcohol is the second most common cause of acute pancreatitis and a leading cause of chronic pancreatitis, often affecting males aged 30–50 years.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Chronic alcohol use, genetic predisposition, smoking, high-fat diet, concurrent gallstone disease.
Prognosis:
The expected outcome or course of the condition over time.
Variable; improved with alcohol cessation. Chronic cases can lead to irreversible damage, diabetes, and complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic pancreatitis, pseudocysts, diabetes mellitus, malnutrition, pancreatic cancer, or organ failure.
Pancreatic Adenocarcinoma
Specialty: Gastrointestinal
Category: Gallbladder and Biliary Tract Disorders
Sub-category: Pancreatic Tumors
Symptoms:
abdominal pain radiating to the back; unexplained weight loss; jaundice; loss of appetite; nausea; vomiting; new-onset diabetes; fatigue
Root Cause:
Malignant tumor originating from the exocrine cells of the pancreas, often associated with mutations in KRAS, p53, or SMAD4 genes. It often causes obstruction of the bile ducts or invasion of nearby tissues.
How it's Diagnosed: videos
Imaging studies like CT or MRI scans; endoscopic ultrasound (EUS) with biopsy; CA 19-9 tumor marker blood test; fine-needle aspiration biopsy
Treatment:
Array
Medications:
Chemotherapeutic agents such as gemcitabine (antimetabolite), nab-paclitaxel (microtubule inhibitor), or FOLFIRINOX (combination regimen including oxaliplatin , irinotecan , fluorouracil , and leucovorin ).
Prevalence:
How common the health condition is within a specific population.
Accounts for approximately 90% of pancreatic cancers; globally, it is the 7th leading cause of cancer-related deaths.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Smoking; chronic pancreatitis; family history of pancreatic cancer; obesity; type 2 diabetes; genetic syndromes such as BRCA mutations or Lynch syndrome
Prognosis:
The expected outcome or course of the condition over time.
Poor prognosis; the 5-year survival rate is approximately 10%, with earlier detection improving outcomes.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Obstruction of the bile duct or intestines; diabetes; malnutrition; metastasis to the liver or peritoneum; pain requiring intensive palliative care
Pancreatic Cysts
Specialty: Gastrointestinal
Category: Gallbladder and Biliary Tract Disorders
Sub-category: Other Pancreatic Disorders
Symptoms:
abdominal pain; nausea; vomiting; jaundice (if the cyst compresses the bile duct); unintended weight loss; palpable mass in the abdomen
Root Cause:
Fluid-filled sacs in the pancreas caused by a variety of conditions, such as pancreatitis, trauma, or neoplasms.
How it's Diagnosed: videos
Imaging studies like CT scan, MRI, or endoscopic ultrasound (EUS), combined with fine-needle aspiration for cyst fluid analysis.
Treatment:
Treatment depends on the type of cyst. Observation for benign or asymptomatic cysts, drainage, or surgical removal for symptomatic, infected, or potentially malignant cysts.
Medications:
Antibiotics like ciprofloxacin or metronidazole for infected cysts; proton pump inhibitors (PPIs) to reduce pancreatic inflammation in associated conditions.
Prevalence:
How common the health condition is within a specific population.
Seen in approximately 10-20% of patients undergoing imaging for unrelated reasons; prevalence increases with age.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Acute or chronic pancreatitis, alcohol use, gallstones, abdominal trauma, family history of pancreatic cysts.
Prognosis:
The expected outcome or course of the condition over time.
Generally good for benign cysts; malignant potential depends on the type (e.g., intraductal papillary mucinous neoplasm, or IPMN, has a higher risk).
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Risk of rupture, infection, hemorrhage, or transformation into pancreatic cancer.
Hereditary Pancreatitis
Specialty: Gastrointestinal
Category: Pancreatic Disorders
Sub-category: Genetic Pancreatic Disorders
Symptoms:
recurrent episodes of abdominal pain; nausea; vomiting; jaundice; steatorrhea; chronic fatigue; weight loss
Root Cause:
Genetic mutations (e.g., PRSS1, SPINK1, CFTR) leading to abnormal pancreatic enzyme activity and recurrent inflammation of the pancreas.
How it's Diagnosed: videos
Genetic testing, family history, imaging studies (CT or MRI), and endoscopic retrograde cholangiopancreatography (ERCP).
Treatment:
Pain management, pancreatic enzyme replacement therapy (PERT), dietary modifications, and in severe cases, total pancreatectomy with islet cell autotransplantation.
Medications:
Analgesics (acetaminophen , NSAIDs, or opioids for severe pain), pancreatic enzyme supplements, antioxidants to reduce inflammation.
Prevalence:
How common the health condition is within a specific population.
Rare condition, accounting for less than 1% of chronic pancreatitis cases; higher prevalence in families with known mutations.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Positive family history, specific genetic mutations (e.g., PRSS1 mutation).
Prognosis:
The expected outcome or course of the condition over time.
Variable; depends on frequency and severity of episodes. Higher risk of developing diabetes and pancreatic cancer over time.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic pancreatitis, pancreatic insufficiency, diabetes mellitus, pancreatic cancer.
Gastroparesis
Specialty: Gastrointestinal
Category: General and Miscellaneous GI Conditions
Sub-category: Motility Disorders
Symptoms:
nausea; vomiting; early satiety; bloating; abdominal pain; weight loss; poor appetite
Root Cause:
Impaired gastric motility due to delayed emptying of the stomach without mechanical obstruction; often associated with nerve or muscle dysfunction.
How it's Diagnosed: videos
Gastric emptying studies (e.g., scintigraphy, breath tests), upper endoscopy to rule out obstruction, and imaging such as CT or MRI to assess anatomy.
Treatment:
Dietary modifications (small, low-fat, low-fiber meals), prokinetic medications, antiemetics, and in severe cases, interventions like gastric electrical stimulation or jejunal feeding tubes.
Medications:
Prokinetic agents such as metoclopramide (a dopamine antagonist) and erythromycin (a macrolide antibiotic) are prescribed to enhance gastric motility. Antiemetics, such as ondansetron (a serotonin 5-HT3 receptor antagonist) or promethazine (a phenothiazine derivative ), are used to control nausea and vomiting.
Prevalence:
How common the health condition is within a specific population.
Affects an estimated 4% of the U.S. population, with higher prevalence in individuals with diabetes or post-surgical complications.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Diabetes mellitus (type 1 and 2), prior abdominal surgery, systemic disorders affecting nerves or muscles (e.g., Parkinson’s disease, scleroderma), and certain medications (e.g., opioids, anticholinergics).
Prognosis:
The expected outcome or course of the condition over time.
Varies by severity; manageable with lifestyle changes and medications, but symptoms can persist and significantly affect quality of life.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Severe malnutrition, dehydration, bezoar formation, fluctuating blood glucose levels in diabetic patients, and impaired medication absorption.
Intestinal Pseudo-Obstruction
Specialty: Gastrointestinal
Category: General and Miscellaneous GI Conditions
Sub-category: Motility Disorders
Symptoms:
abdominal pain; bloating; nausea; vomiting; constipation; diarrhea; malnutrition; failure to thrive in children
Root Cause:
Abnormal motility of the intestines due to dysfunction of the smooth muscle or nerves; mimics a mechanical obstruction but without a physical blockage.
How it's Diagnosed: videos
Abdominal X-rays, CT scans, manometry to evaluate intestinal contractions, and full-thickness biopsies to examine underlying neuromuscular abnormalities.
Treatment:
Management focuses on treating symptoms with dietary adjustments (low-residue or elemental diets), enteral or parenteral nutrition, prokinetic agents, and in some cases, surgical decompression.
Medications:
Prokinetic agents such as neostigmine (a cholinesterase inhibitor) and metoclopramide (a dopamine antagonist) are used to enhance motility. Antispasmodics, such as hyoscine (an anticholinergic agent), may be used to manage painful cramping. Antibiotics, like rifaximin (a gut-specific antibiotic), may be prescribed for bacterial overgrowth.
Prevalence:
How common the health condition is within a specific population.
Rare, with an estimated prevalence of fewer than 1 in 100,000 individuals; can occur as a primary (idiopathic) condition or secondary to systemic diseases.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Genetic predispositions, underlying conditions like scleroderma, systemic lupus erythematosus, neurological disorders, or prior abdominal surgery.
Prognosis:
The expected outcome or course of the condition over time.
Chronic and often progressive; prognosis depends on the underlying cause and response to treatment. Early intervention with nutritional support can improve outcomes.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Severe malnutrition, intestinal perforation, bacterial overgrowth, sepsis, and dependency on parenteral nutrition in advanced cases.
Peritonitis (Spontaneous Bacterial or Secondary)
Specialty: Gastrointestinal
Category: General and Miscellaneous GI Conditions
Sub-category: Peritoneal Disorders
Symptoms:
abdominal pain; fever; nausea; vomiting; bloating; loss of appetite; rebound tenderness; altered mental status (in severe cases)
Root Cause:
Inflammation of the peritoneum caused by bacterial infection, either spontaneous (usually due to liver disease and ascites) or secondary to conditions like a perforated appendix or bowel injury.
How it's Diagnosed: videos
Clinical examination, imaging (CT scan or ultrasound), and diagnostic paracentesis (analysis of peritoneal fluid for white blood cell count, Gram stain, and culture).
Treatment:
Immediate treatment includes antibiotics to target causative bacteria, supportive care (IV fluids, pain management), and surgery (in secondary peritonitis) to repair the underlying source of infection.
Medications:
Broad-spectrum antibiotics such as cefotaxime or piperacillin-tazobactam (antibacterial). In cases of fungal involvement, antifungals like fluconazole may be used.
Prevalence:
How common the health condition is within a specific population.
Spontaneous bacterial peritonitis occurs in 10-30% of patients with cirrhosis and ascites. Secondary peritonitis prevalence depends on underlying conditions like appendicitis or bowel perforation.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Chronic liver disease with ascites, peritoneal dialysis, abdominal surgery, gastrointestinal perforations, trauma, and immunosuppression.
Prognosis:
The expected outcome or course of the condition over time.
Prognosis varies; spontaneous bacterial peritonitis has a 20-40% mortality rate, which improves with prompt treatment. Secondary peritonitis requires surgical intervention and can lead to serious complications without timely management.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Sepsis, multi-organ failure, abscess formation, and recurrent infections.
Neuromyelitis Optica Spectrum Disorder (NMOSD)
Specialty: Neurology
Category: Demyelinating and Autoimmune Disorders
Symptoms:
severe optic neuritis; paralysis or weakness; loss of bladder/bowel control; nausea; vomiting; hiccups
Root Cause:
Autoimmune attack on aquaporin-4 water channels in astrocytes of the CNS, leading to inflammation and demyelination.
How it's Diagnosed: videos
Detection of aquaporin-4 antibodies (AQP4-IgG), MRI showing spinal cord or optic nerve lesions, and clinical symptom history.
Treatment:
Immunosuppressive therapies, plasmapheresis for acute attacks, and preventative treatments to reduce relapses.
Medications:
Rituximab (monoclonal antibody targeting CD20), corticosteroids (e.g., methylprednisolone ), azathioprine , and mycophenolate mofetil (immunosuppressants).
Prevalence:
How common the health condition is within a specific population.
Rare, affecting approximately 1-10 per 100,000 people, more common in women and certain ethnic groups.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Female gender, autoimmune conditions, genetic predisposition, and certain infections.
Prognosis:
The expected outcome or course of the condition over time.
Relapsing disease with potential for severe disability if untreated; early treatment improves outcomes.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Permanent vision loss, spinal cord damage, and secondary infections.
Acute Disseminated Encephalomyelitis (ADEM)
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
fever; headache; nausea; vomiting; confusion; seizures; motor weakness; vision problems; lethargy
Root Cause:
An autoimmune response often triggered by an infection or, less commonly, vaccination, causing inflammation and demyelination in the brain and spinal cord.
How it's Diagnosed: videos
Clinical evaluation, MRI of the brain (showing diffuse demyelination), lumbar puncture (to analyze cerebrospinal fluid), and exclusion of other conditions like multiple sclerosis.
Treatment:
High-dose corticosteroids (e.g., methylprednisolone), plasma exchange (plasmapheresis), intravenous immunoglobulin (IVIG), and supportive care.
Medications:
Corticosteroids (e.g., methylprednisolone for reducing inflammation), IVIG (immunomodulatory therapy), or plasmapheresis (used when steroids are insufficient). Corticosteroids are classified as anti-inflammatory agents.
Prevalence:
How common the health condition is within a specific population.
Rare; estimated annual incidence is 0.4-0.8 per 100,000 people, more common in children than adults.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Recent viral or bacterial infections, recent vaccination, genetic predisposition, or underlying autoimmune disorders.
Prognosis:
The expected outcome or course of the condition over time.
Good in most cases; symptoms often resolve with treatment, although some individuals may experience residual neurological deficits.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Long-term neurological impairment, recurrence (though rare), or progression to conditions like multiple sclerosis in some cases.
Migraine
Specialty: Neurology
Category: Headaches and Pain Syndromes
Symptoms:
severe, throbbing headache; nausea; vomiting; sensitivity to light (photophobia); sensitivity to sound (phonophobia); visual disturbances (auras in some cases)
Root Cause:
Abnormal brain activity affecting nerve signaling, blood flow, and brain chemicals.
How it's Diagnosed: videos
Clinical evaluation based on patient history and symptoms, fulfilling International Classification of Headache Disorders (ICHD) criteria; imaging is used to rule out other conditions.
Treatment:
Lifestyle modifications, migraine prophylaxis, acute migraine treatments.
Medications:
Acute treatments include triptans (e.g., sumatriptan , rizatriptan , serotonin receptor agonists), NSAIDs (e.g., ibuprofen , naproxen ), and antiemetics (e.g., metoclopramide ). Preventive treatments include beta-blockers (e.g., propranolol ), calcium channel blockers (e.g., verapamil ), anticonvulsants (e.g., topiramate , valproate), and CGRP inhibitors (e.g., erenumab ).
Prevalence:
How common the health condition is within a specific population.
Affects approximately 15% of the global population, with higher prevalence in females.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Family history, hormonal changes (e.g., menstruation), stress, certain foods, dehydration, lack of sleep, sensory triggers.
Prognosis:
The expected outcome or course of the condition over time.
Chronic condition with varying frequency and severity; managed effectively in most cases with treatment.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Increased risk of stroke, medication overuse headache, depression, and anxiety.
Migraine Without Aura
Specialty: Neurology
Category: Headaches and Pain Syndromes
Symptoms:
pulsating or throbbing headache; nausea; vomiting; sensitivity to light and sound; pain aggravated by physical activity
Root Cause:
Dysfunction in brainstem and interactions with the trigeminal nerve, leading to abnormal pain processing and inflammation.
How it's Diagnosed: videos
Based on ICHD criteria; recurrent headaches lasting 4-72 hours with at least two pain characteristics and associated symptoms.
Treatment:
Acute treatments focus on symptom relief, and preventive measures aim to reduce frequency and severity.
Medications:
Acute medications include triptans, NSAIDs, acetaminophen , and antiemetics; prophylactic medications include beta-blockers (e.g., propranolol ), anticonvulsants (e.g., topiramate ), and CGRP inhibitors (e.g., fremanezumab ).
Prevalence:
How common the health condition is within a specific population.
More common than migraines with aura, affecting up to 10% of the global population.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Stress, hormonal changes, sleep disturbances, dehydration, and dietary triggers.
Prognosis:
The expected outcome or course of the condition over time.
Typically chronic but manageable; treatment improves quality of life.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Medication overuse headache, anxiety, depression, and increased stroke risk in specific populations.
Meningitis (Bacterial, Viral, Fungal)
Specialty: Neurology
Category: Infections and Inflammatory Diseases
Symptoms:
fever; headache; neck stiffness; nausea; vomiting; sensitivity to light (photophobia); altered mental status; seizures
Root Cause:
Inflammation of the meninges, typically caused by bacterial, viral, or fungal infections.
How it's Diagnosed: videos
Lumbar puncture to analyze cerebrospinal fluid (CSF); blood cultures; imaging (CT/MRI) for complications or suspected mass lesions; PCR for viral causes.
Treatment:
Treatment depends on the cause. Bacterial meningitis requires prompt antibiotic therapy, while viral meningitis may resolve on its own or require supportive care. Fungal meningitis is treated with antifungals.
Medications:
For bacterial meningitis - Empiric antibiotics such as ceftriaxone and vancomycin , with targeted therapy after pathogen identification. Corticosteroids (e.g., dexamethasone ) may reduce inflammation. For viral meningitis - Antiviral drugs like acyclovir for herpes simplex virus. For fungal meningitis - Amphotericin B and flucytosine for Cryptococcus species.
Prevalence:
How common the health condition is within a specific population.
Varies globally; bacterial meningitis is more common in low-income regions, while viral meningitis is more frequent in developed countries.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Close contact with infected individuals, weakened immune system, head injury, neurosurgical procedures, certain geographic areas (e.g., meningitis belt in Sub-Saharan Africa).
Prognosis:
The expected outcome or course of the condition over time.
Bacterial meningitis can be life-threatening if untreated but has good outcomes with prompt treatment. Viral meningitis usually resolves without long-term effects. Fungal meningitis has a more guarded prognosis, especially in immunocompromised patients.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Brain damage, hearing loss, seizures, hydrocephalus, septic shock, death (especially in untreated bacterial cases).
Brain Abscess
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
headache; fever; nausea; vomiting; neurological deficits; seizures; altered mental status
Root Cause:
Focal collection of pus in the brain tissue, often caused by bacterial or fungal infections entering through the bloodstream, contiguous spread, or trauma.
How it's Diagnosed: videos
MRI or CT scan with contrast, blood cultures, and biopsy of the abscess for microbiological testing.
Treatment:
Surgical drainage or aspiration, combined with broad-spectrum antibiotics tailored based on culture results.
Medications:
Antibiotics such as ceftriaxone (a cephalosporin) or metronidazole (an anti-anaerobic agent). For fungal infections, amphotericin B or fluconazole may be used.
Prevalence:
How common the health condition is within a specific population.
Rare, with an estimated incidence of 0.3 to 1.3 cases per 100,000 people annually.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Immunocompromised status (HIV, organ transplantation), chronic sinusitis, otitis media, congenital heart defects, head trauma.
Prognosis:
The expected outcome or course of the condition over time.
With prompt treatment, mortality rates are around 10–20%, but neurological deficits may persist.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Increased intracranial pressure, brain herniation, seizures, recurrence of infection, or neurological impairments.
Neurocysticercosis
Specialty: Infectious Diseases
Category: CNS Infections
Sub-category: Parasitic Infections
Symptoms:
seizures; headache; nausea; vomiting; vision problems; hydrocephalus; altered mental status
Root Cause:
Infection of the central nervous system by Taenia solium larvae (pork tapeworm), leading to cyst formation in the brain.
How it's Diagnosed: videos
Neuroimaging (MRI or CT) revealing cysts or calcifications, serologic tests for T. solium antibodies, and CSF analysis.
Treatment:
Antiparasitic therapy with albendazole or praziquantel, corticosteroids to reduce inflammation, anticonvulsants for seizure management, and surgical intervention in severe cases.
Medications:
Albendazole (antiparasitic), praziquantel (antiparasitic), dexamethasone (corticosteroid), and levetiracetam or phenytoin (anticonvulsants).
Prevalence:
How common the health condition is within a specific population.
Leading cause of acquired epilepsy in developing countries; affects millions globally, particularly in regions with poor sanitation.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Consumption of undercooked pork, poor sanitation, close contact with infected individuals, and living in endemic areas.
Prognosis:
The expected outcome or course of the condition over time.
Favorable with treatment in uncomplicated cases; long-term anticonvulsant therapy may be required for seizure control.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic epilepsy, hydrocephalus, intracranial hypertension, and neurological deficits.
Glioblastoma Multiforme (GBM)
Specialty: Oncology
Category: Solid Tumors
Sub-category: Central Nervous System (CNS) Tumors
Symptoms:
headaches; nausea; vomiting; seizures; neurological deficits (e.g., weakness, vision changes); cognitive or personality changes; speech difficulties
Root Cause:
Uncontrolled proliferation of astrocytes, leading to a highly aggressive and infiltrative malignant tumor in the brain.
How it's Diagnosed: videos
Magnetic Resonance Imaging (MRI) with contrast, biopsy for histopathological confirmation, molecular testing (e.g., MGMT promoter methylation, IDH mutation status).
Treatment:
Surgery for tumor resection, followed by radiotherapy and temozolomide chemotherapy. Experimental treatments include targeted therapies, tumor-treating fields (TTFields), and immunotherapy.
Medications:
Temozolomide (alkylating agent), bevacizumab (anti-VEGF monoclonal antibody), corticosteroids like dexamethasone (to reduce cerebral edema).
Prevalence:
How common the health condition is within a specific population.
Accounts for approximately 15% of all primary brain tumors; incidence is 3.19 cases per 100,000 individuals annually.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Advanced age, male gender, exposure to ionizing radiation, history of certain genetic disorders (e.g., Li-Fraumeni syndrome, Turcot syndrome).
Prognosis:
The expected outcome or course of the condition over time.
Poor prognosis; median survival is 15-18 months with standard therapy, and 5-year survival rates are below 10%.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Cerebral edema, increased intracranial pressure, neurological deficits, cognitive decline, seizures, recurrence of tumor.
Ependymomas
Specialty: Oncology
Category: Solid Tumors
Sub-category: Central Nervous System (CNS) Tumors
Symptoms:
headaches; nausea; vomiting; hydrocephalus-related symptoms (e.g., balance issues, gait problems); visual disturbances; back pain (if spinal cord involvement)
Root Cause:
Tumors arising from ependymal cells lining the ventricles of the brain and the central canal of the spinal cord.
How it's Diagnosed: videos
MRI with contrast, biopsy for histological confirmation, cerebrospinal fluid (CSF) analysis for metastatic disease.
Treatment:
Surgical resection, followed by radiotherapy; chemotherapy in select cases (especially in pediatric patients).
Medications:
Corticosteroids (e.g., dexamethasone ) for symptom management, chemotherapy agents like cisplatin and vincristine in some pediatric cases.
Prevalence:
How common the health condition is within a specific population.
Rare, accounting for 2-3% of all primary brain tumors; more common in children than adults.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Genetic syndromes (e.g., Neurofibromatosis Type 2), exposure to ionizing radiation.
Prognosis:
The expected outcome or course of the condition over time.
Prognosis varies by grade and resectability; 5-year survival rates for Grade II are 50-70%, while higher-grade tumors have poorer outcomes.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Hydrocephalus, neurological deficits, tumor recurrence, metastatic spread in the CNS.
Concussion
Specialty: Neurology
Category: Traumatic Brain and Spinal Cord Injuries
Symptoms:
headache; confusion; dizziness; nausea; vomiting; blurred vision; sensitivity to light and noise; memory loss; difficulty concentrating; fatigue
Root Cause:
A mild traumatic brain injury caused by a sudden impact or jolt to the head, leading to temporary disruption of brain function.
How it's Diagnosed: videos
Clinical evaluation (patient history, symptom analysis, and physical examination), neurocognitive testing, imaging tests like CT or MRI (if severe symptoms or risk of complications).
Treatment:
Rest, gradual return to activities, symptom management, cognitive and physical rehabilitation if needed.
Medications:
Pain relievers like acetaminophen or ibuprofen for headaches. Prescription medications, such as amitriptyline (tricyclic antidepressant) or topiramate (antiepileptic), may be used for post-concussion headaches or migraines.
Prevalence:
How common the health condition is within a specific population.
Common; estimated 1.6–3.8 million concussions occur annually in the U.S. related to sports and recreational activities.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Participation in contact sports, history of previous concussions, motor vehicle accidents, falls, younger age (children and adolescents).
Prognosis:
The expected outcome or course of the condition over time.
Generally good, with most people recovering fully within weeks to months; symptoms may persist longer in post-concussion syndrome.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Post-concussion syndrome, second impact syndrome, chronic traumatic encephalopathy (CTE), persistent cognitive or emotional problems.
Traumatic Brain Injury (TBI)
Specialty: Neurology
Category: Traumatic Brain and Spinal Cord Injuries
Symptoms:
loss of consciousness; headache; confusion; memory loss; dizziness; vomiting; seizures; speech difficulties; weakness or numbness; changes in behavior
Root Cause:
Brain damage caused by external force, such as a blow to the head, penetration by an object, or violent shaking.
How it's Diagnosed: videos
Physical and neurological examinations, imaging tests like CT scans or MRIs, Glasgow Coma Scale assessment.
Treatment:
Emergency stabilization, surgical intervention if necessary (to relieve pressure or repair damage), physical and cognitive rehabilitation, supportive care.
Medications:
Diuretics (e.g., mannitol ) to reduce brain swelling; anticonvulsants (e.g., levetiracetam ) to prevent seizures; sedatives (e.g., propofol ) for agitation or to manage intracranial pressure.
Prevalence:
How common the health condition is within a specific population.
About 2.8 million emergency department visits for TBI in the U.S. annually; common in all age groups, particularly young adults and the elderly.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Falls, vehicle accidents, sports injuries, physical violence, military combat exposure.
Prognosis:
The expected outcome or course of the condition over time.
Varies widely; mild TBIs often resolve fully, while severe TBIs may result in long-term disabilities or death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Seizures, infections, hydrocephalus, cognitive or emotional impairments, death.
Subdural Hematoma
Specialty: Neurology
Category: Traumatic Brain and Spinal Cord Injuries
Symptoms:
headache; confusion; drowsiness; vomiting; seizures; weakness; slurred speech; loss of consciousness
Root Cause:
Bleeding between the dura mater and the arachnoid membrane, typically caused by trauma to the head.
How it's Diagnosed: videos
Diagnosed through neuroimaging, primarily CT scans or MRI, to detect blood accumulation.
Treatment:
Treatment ranges from observation for mild cases to surgical intervention (craniotomy or burr hole drainage) for severe cases.
Medications:
Antiepileptic drugs (AEDs) such as levetiracetam or phenytoin may be prescribed to prevent seizures. Pain management medications like acetaminophen are also used.
Prevalence:
How common the health condition is within a specific population.
Subdural hematomas are relatively common, especially among older adults and individuals on anticoagulant therapy.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Head trauma, older age, use of blood thinners, alcohol abuse, and brain atrophy.
Prognosis:
The expected outcome or course of the condition over time.
Variable depending on severity and treatment; mild cases have a good prognosis, but severe cases can lead to permanent neurological impairment or death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Increased intracranial pressure, brain herniation, chronic subdural hematoma, seizures, and cognitive deficits.
Epidural Hematoma
Specialty: Neurology
Category: Traumatic Brain and Spinal Cord Injuries
Symptoms:
brief loss of consciousness followed by a lucid interval; headache; vomiting; confusion; weakness; seizures; unequal pupil size; progressive loss of consciousness
Root Cause:
Accumulation of blood between the skull and dura mater, often due to the rupture of an artery, commonly the middle meningeal artery, from trauma.
How it's Diagnosed: videos
Diagnosed through CT scans or MRI to visualize blood collection.
Treatment:
Emergency surgical evacuation of the hematoma via craniotomy or burr hole surgery.
Medications:
Anticonvulsants like levetiracetam to prevent seizures and analgesics for pain management.
Prevalence:
How common the health condition is within a specific population.
Less common than subdural hematomas but more frequently observed in younger patients with head trauma.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Skull fractures, head trauma, high-impact injuries, and anticoagulant therapy.
Prognosis:
The expected outcome or course of the condition over time.
Good if treated promptly; untreated cases can lead to brain herniation and death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Increased intracranial pressure, brain herniation, permanent neurological deficits, and death if untreated.
Dandy-Walker Syndrome
Specialty: Neurology
Category: Congenital and Genetic Disorders
Symptoms:
developmental delays; progressive head enlargement; irritability; vomiting; unsteady gait; seizures
Root Cause:
Congenital malformation of the cerebellum and fourth ventricle, causing CSF obstruction.
How it's Diagnosed: videos
Diagnosed using prenatal or postnatal imaging (MRI or ultrasound).
Treatment:
Treated with shunting for hydrocephalus and supportive therapies for developmental delays.
Medications:
Antiepileptics for seizure management if present.
Prevalence:
How common the health condition is within a specific population.
Rare; approximately 1 in 25,000–35,000 live births.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Chromosomal abnormalities, maternal infections, genetic predispositions.
Prognosis:
The expected outcome or course of the condition over time.
Varies; with proper management, children may lead functional lives, but developmental challenges are common.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Cognitive impairments, motor deficits, hydrocephalus, and seizures.
Leigh’s Syndrome
Specialty: Neurology
Category: Congenital and Genetic Disorders
Symptoms:
loss of motor skills; seizures; difficulty breathing; poor muscle tone; failure to thrive; vomiting; weakness
Root Cause:
Mutations in mitochondrial or nuclear DNA affecting energy production (oxidative phosphorylation).
How it's Diagnosed: videos
Diagnosed via genetic testing, brain MRI, and metabolic studies.
Treatment:
Treated symptomatically with supportive care and experimental therapies, as no cure exists.
Medications:
None curative; symptom management includes anti-epileptics like levetiracetam and supportive supplements.
Prevalence:
How common the health condition is within a specific population.
Estimated at 1 in 40,000 live births.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Inherited mitochondrial or nuclear gene mutations.
Prognosis:
The expected outcome or course of the condition over time.
Poor; most patients do not survive beyond childhood.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Respiratory failure, severe neurological decline, and organ dysfunction.
Peptic ulcer disease
Specialty: Senior Health and Geriatrics
Category: Chronic Diseases and Multimorbidity
Sub-category: Gastrointestinal and Hepatic Disorders
Symptoms:
abdominal pain; bloating; nausea; vomiting; heartburn; loss of appetite; weight loss
Root Cause:
Ulcers in the stomach lining or the first part of the small intestine caused by an imbalance between stomach acid and protective factors.
How it's Diagnosed: videos
Based on symptoms, endoscopy, and tests for H. pylori infection (blood, breath, or stool tests).
Treatment:
Proton pump inhibitors (PPIs), antibiotics for H. pylori infection, antacids, and sometimes surgery.
Medications:
Proton pump inhibitors (e.g., lansoprazole ), H2 blockers (e.g., ranitidine), antibiotics (e.g., clarithromycin , amoxicillin for H. pylori), and antacids.
Prevalence:
How common the health condition is within a specific population.
Affects 10-15% of people at some point in their lives, more common in those aged 55-70.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
H. pylori infection, long-term NSAID use, alcohol use, smoking, stress, and spicy foods.
Prognosis:
The expected outcome or course of the condition over time.
With appropriate treatment, most ulcers heal within a few weeks; recurrence is common if risk factors are not managed.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Gastrointestinal bleeding, perforation, gastric cancer.
Milk Allergy
Specialty: Allergies and Immunology
Category: Allergic Disorders
Sub-category: Food Allergies
Symptoms:
hives; vomiting; stomach cramps; diarrhea; wheezing; anaphylaxis in severe cases
Root Cause:
Immune system reaction to milk proteins, primarily casein or whey.
How it's Diagnosed: videos
Skin prick testing, specific IgE blood tests, oral food challenges under medical supervision.
Treatment:
Complete avoidance of milk and milk-containing products, use of epinephrine for anaphylaxis.
Medications:
Epinephrine auto-injectors (e.g., EpiPen, Auvi-Q) for anaphylaxis and oral antihistamines (e.g., Diphenhydramine , Loratadine ) for mild reactions.
Prevalence:
How common the health condition is within a specific population.
Affects approximately 1-3% of children; often outgrown by adolescence.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Family history of allergies, eczema, or asthma; early exposure to cow's milk proteins.
Prognosis:
The expected outcome or course of the condition over time.
Good for most children as they often outgrow it; lifelong management needed for persistent cases.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Anaphylaxis, nutritional deficiencies if not replaced properly, social challenges.
Peanut Allergy
Specialty: Allergies and Immunology
Category: Allergic Disorders
Sub-category: Food Allergies
Symptoms:
hives; swelling; difficulty breathing; vomiting; anaphylaxis
Root Cause:
Immune system response to peanut proteins, particularly arachin and conarachin.
How it's Diagnosed: videos
Skin prick tests, specific IgE blood tests, oral food challenge.
Treatment:
Avoidance of peanuts, epinephrine for anaphylaxis, oral immunotherapy under medical supervision.
Medications:
Epinephrine auto-injectors (e.g., EpiPen, Auvi-Q), antihistamines (e.g., Diphenhydramine , Cetirizine ), and oral immunotherapy (e.g., Palforzia in specific cases).
Prevalence:
How common the health condition is within a specific population.
Affects approximately 1-2% of the population; prevalence has been rising in recent decades.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Family history, eczema, early or delayed introduction of peanuts in infancy.
Prognosis:
The expected outcome or course of the condition over time.
Lifelong condition for many; emerging treatments like oral immunotherapy offer hope for desensitization.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Severe anaphylaxis, social and psychological impacts, dietary restrictions.
Wheat Allergy
Specialty: Allergies and Immunology
Category: Allergic Disorders
Sub-category: Food Allergies
Symptoms:
hives; swelling; nausea; vomiting; difficulty breathing; anaphylaxis
Root Cause:
Immune system reaction to proteins found in wheat, including gluten and albumin.
How it's Diagnosed: videos
Skin prick tests, specific IgE blood tests, oral food challenge.
Treatment:
Avoidance of wheat products, substitution with gluten-free grains, use of epinephrine for severe reactions.
Medications:
Epinephrine auto-injectors (e.g., EpiPen, Auvi-Q) and oral antihistamines (e.g., Diphenhydramine , Loratadine ).
Prevalence:
How common the health condition is within a specific population.
Affects approximately 0.2-1% of children and adults.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Family history of allergies, atopic conditions, prior allergic reactions to wheat.
Prognosis:
The expected outcome or course of the condition over time.
Many children outgrow it by age 12; adults may need lifelong management.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Anaphylaxis, misdiagnosis with celiac disease or gluten sensitivity, limited dietary options.
Eosinophilic Gastroenteritis
Specialty: Allergies and Immunology
Category: Other Related Disorders
Sub-category: Eosinophilic Disorders
Symptoms:
abdominal pain; nausea; diarrhea; vomiting; weight loss; fatigue; anemia
Root Cause:
Eosinophilic infiltration of the gastrointestinal tract, likely triggered by food or environmental allergens.
How it's Diagnosed: videos
Endoscopy with biopsy showing eosinophilic infiltration, imaging studies, and blood tests for eosinophilia.
Treatment:
Elimination diets, corticosteroids, and symptom management (e.g., anti-nausea medications).
Medications:
Corticosteroids (e.g., Prednisone ) and dietary modifications.
Prevalence:
How common the health condition is within a specific population.
Rare; precise prevalence is unknown.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Allergic diseases, family history of eosinophilic disorders, and certain infections.
Prognosis:
The expected outcome or course of the condition over time.
Chronic but manageable with treatment; symptoms may relapse without ongoing management.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Bowel obstruction, malabsorption, and perforation in severe cases.
Hereditary Angioedema (HAE)
Specialty: Allergies and Immunology
Category: Other Related Disorders
Symptoms:
swelling of the skin and mucosal tissues; abdominal pain; nausea; vomiting; difficulty breathing; laryngeal swelling that may lead to airway obstruction
Root Cause:
Genetic mutation leading to a deficiency or dysfunction of C1 esterase inhibitor (C1-INH), causing uncontrolled activation of the complement system and increased bradykinin production.
How it's Diagnosed: videos
Blood tests measuring C1-INH levels and function, complement component C4 levels, and genetic testing for mutations in the SERPING1 gene.
Treatment:
C1-INH replacement therapy, bradykinin receptor antagonists (e.g., icatibant), kallikrein inhibitors (e.g., lanadelumab), and prophylactic medications for preventing attacks.
Medications:
C1 esterase inhibitor replacement therapy, bradykinin receptor antagonists (e.g., Icatibant ), and androgens (e.g., Danazol ).
Prevalence:
How common the health condition is within a specific population.
Estimated at 1 in 50,000 to 1 in 100,000 individuals worldwide.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Family history of HAE (autosomal dominant inheritance), stress, trauma, infections, hormonal changes, certain medications (e.g., ACE inhibitors).
Prognosis:
The expected outcome or course of the condition over time.
With proper management, most patients can lead normal lives; untreated cases may result in life-threatening airway obstruction.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Potentially fatal laryngeal edema, psychological distress due to unpredictable swelling episodes, reduced quality of life, and delays in diagnosis.
Penetrating brain injury (e.g., gunshot wounds)
Specialty: Trauma and Injuries
Category: Head and Neck Injuries
Sub-category: Head Injuries
Symptoms:
loss of consciousness; severe headache; nausea; vomiting; neurological deficits; seizures; cognitive impairment; hemorrhage
Root Cause:
Direct injury caused by a foreign object (e.g., bullet) penetrating the skull and brain tissue, causing localized damage and potential hemorrhage.
How it's Diagnosed: videos
Diagnosis is confirmed via CT scans or MRI, and clinical assessment for neurological deficits.
Treatment:
Immediate surgical intervention may be required to remove the foreign object and control bleeding, followed by intensive care, brain stabilization, and rehabilitation. Antibacterial treatment may be administered to prevent infections.
Medications:
Antibiotics (e.g., ceftriaxone , vancomycin ) to prevent infections, analgesics (e.g., morphine for pain), and anticonvulsants (e.g., phenytoin ) for seizure prevention. These medications include antibiotics, analgesics, and anticonvulsants.
Prevalence:
How common the health condition is within a specific population.
Penetrating brain injuries, such as those caused by gunshot wounds, are less common than blunt trauma but are frequently seen in violence-prone regions, accounting for around 10% of traumatic brain injuries.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Gunshot wounds, violent crime, war zones, and industrial accidents are significant risk factors.
Prognosis:
The expected outcome or course of the condition over time.
Prognosis depends on the severity of the injury, the area of the brain affected, and the speed of medical intervention. Recovery may vary from complete recovery to permanent disability or death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Infection (e.g., meningitis), hemorrhagic shock, cognitive deficits, paralysis, persistent seizures, and post-traumatic stress disorder (PTSD).
Liver laceration
Specialty: Trauma and Injuries
Category: Blunt Abdominal Trauma
Sub-category: Solid Organ Injuries
Symptoms:
right upper quadrant pain; abdominal tenderness; signs of internal bleeding (e.g., hypotension, tachycardia); nausea; vomiting; ecchymosis over the abdomen
Root Cause:
Traumatic damage to the liver caused by blunt force trauma, often resulting in bleeding and disruption of hepatic tissue.
How it's Diagnosed: videos
Clinical examination, focused assessment with sonography for trauma (FAST), contrast-enhanced CT scan, and laboratory tests (e.g., hemoglobin levels, liver enzymes).
Treatment:
Management depends on severity. Minor lacerations may be managed conservatively with observation and fluid resuscitation. Severe cases may require surgical intervention (e.g., laparotomy, hemostasis, or liver packing).
Medications:
Pain relief medications such as acetaminophen or opioids for severe pain. In cases of infection risk, prophylactic antibiotics like ceftriaxone (cephalosporin class) may be used.
Prevalence:
How common the health condition is within a specific population.
Common in patients with blunt abdominal trauma; occurs in approximately 15-20% of such cases.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Motor vehicle collisions, falls from significant heights, sports injuries, or assaults involving blunt force to the abdomen.
Prognosis:
The expected outcome or course of the condition over time.
Favorable in minor cases with proper treatment; severe lacerations carry a higher risk of mortality due to hemorrhage or associated injuries.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Hemorrhagic shock, bile leakage, peritonitis, abscess formation, sepsis.
Splenic rupture
Specialty: Trauma and Injuries
Category: Blunt Abdominal Trauma
Sub-category: Solid Organ Injuries
Symptoms:
left upper quadrant pain; kehr's sign (referred pain to the left shoulder); abdominal distension; hypotension; tachycardia; nausea; vomiting
Root Cause:
Splenic parenchymal and capsule disruption due to blunt trauma, leading to internal bleeding and potential hemodynamic instability.
How it's Diagnosed: videos
Physical examination, FAST scan, contrast-enhanced CT scan of the abdomen, and monitoring of hemoglobin levels.
Treatment:
Non-operative management with close monitoring and bed rest in stable cases. Unstable cases may require splenectomy or splenic repair surgery.
Medications:
Pain management with acetaminophen or NSAIDs. Post-splenectomy patients may require prophylactic vaccines against encapsulated bacteria (e.g., pneumococcal, meningococcal, and Haemophilus influenzae).
Prevalence:
How common the health condition is within a specific population.
Occurs in approximately 25-30% of blunt abdominal trauma cases, making it the most commonly injured organ.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Blunt abdominal trauma from vehicle collisions, falls, or contact sports.
Prognosis:
The expected outcome or course of the condition over time.
Good in stable cases with non-operative management; splenectomy patients have an increased lifelong risk of infections (overwhelming post-splenectomy infection, OPSI).
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Hemorrhagic shock, infection, OPSI, abscess formation.
Pancreatic injury
Specialty: Trauma and Injuries
Category: Blunt Abdominal Trauma
Sub-category: Solid Organ Injuries
Symptoms:
epigastric pain; nausea; vomiting; signs of peritonitis (in severe cases); elevated serum amylase or lipase
Root Cause:
Disruption or contusion of the pancreas caused by blunt trauma, leading to leakage of pancreatic enzymes and tissue inflammation.
How it's Diagnosed: videos
Clinical examination, serum amylase and lipase levels, CT scan with contrast, and endoscopic retrograde cholangiopancreatography (ERCP) in select cases.
Treatment:
Mild cases managed with bowel rest, hydration, and monitoring. Severe injuries may require surgical drainage, debridement, or partial pancreatectomy.
Medications:
Pain management with opioids. Antibiotics like piperacillin-tazobactam (penicillin class) for associated infections or abscesses.
Prevalence:
How common the health condition is within a specific population.
Rare, occurring in less than 5% of blunt abdominal trauma cases.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Blunt force trauma from vehicle collisions, bicycle handlebars, or direct abdominal impacts.
Prognosis:
The expected outcome or course of the condition over time.
Variable; minor injuries have good outcomes, but severe injuries can result in significant morbidity.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Pancreatic fistula, abscess formation, pseudocyst, diabetes mellitus, sepsis.
Intestinal perforation
Specialty: Trauma and Injuries
Category: Blunt Abdominal Trauma
Sub-category: Hollow organ injuries
Symptoms:
severe abdominal pain; fever; nausea; vomiting; abdominal distension; tenderness; guarding; rebound tenderness
Root Cause:
A tear or hole in the wall of the intestines that leads to leakage of intestinal contents into the abdominal cavity, causing peritonitis and infection.
How it's Diagnosed: videos
Clinical examination, imaging studies like X-rays (showing free air under the diaphragm), CT scans, blood tests showing elevated white blood cells (leukocytosis), and exploratory surgery.
Treatment:
Emergency surgery (laparotomy or laparoscopy) to repair the perforation, clean the abdominal cavity, and address any infection.
Medications:
Broad-spectrum antibiotics, such as piperacillin-tazobactam or ceftriaxone with metronidazole , are prescribed to manage infections. These are classified as antibacterial agents. Pain relievers and IV fluids may also be administered.
Prevalence:
How common the health condition is within a specific population.
Common in cases of trauma, infections, or gastrointestinal conditions like peptic ulcers or diverticulitis. Exact prevalence varies by the underlying cause.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Abdominal trauma, gastrointestinal conditions (e.g., Crohn’s disease, diverticulitis, or cancer), infections, foreign body ingestion, and certain medications like NSAIDs.
Prognosis:
The expected outcome or course of the condition over time.
Favorable with prompt treatment but worsens with delays, leading to life-threatening sepsis.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Peritonitis, sepsis, abscess formation, multi-organ failure, and death if untreated.
Stomach rupture
Specialty: Trauma and Injuries
Category: Blunt Abdominal Trauma
Sub-category: Hollow organ injuries
Symptoms:
severe upper abdominal pain; abdominal swelling; nausea; vomiting; hematemesis (vomiting blood); hypotension; shock
Root Cause:
A breach in the stomach wall, often due to blunt trauma, increased gastric pressure, or penetrating injuries, leading to leakage of gastric contents into the abdominal cavity.
How it's Diagnosed: videos
Imaging (X-rays showing free air under the diaphragm), CT scan, upper GI endoscopy, and clinical symptoms indicative of peritonitis or shock.
Treatment:
Emergency surgical intervention to repair the rupture and clean the abdominal cavity. Postoperative care includes infection control and nutritional support.
Medications:
Broad-spectrum antibiotics, such as ceftriaxone or meropenem , combined with metronidazole to prevent infection. These are classified as antibacterial agents. Proton pump inhibitors (e.g., pantoprazole or omeprazole ) may be prescribed to reduce stomach acid and promote healing. Pain relief medications (e.g., opioids or acetaminophen ) are also used.
Prevalence:
How common the health condition is within a specific population.
Rare but associated with significant blunt trauma (e.g., motor vehicle accidents) or extreme gastric distension (e.g., binge eating with vomiting).
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Blunt abdominal trauma, excessive gastric distension, gastric ulcers, ingestion of corrosive substances, or prior gastric surgeries.
Prognosis:
The expected outcome or course of the condition over time.
With prompt surgical treatment, survival is high; delays increase risk of sepsis and death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Peritonitis, sepsis, hemorrhage, abscess formation, and multi-organ failure.
Rhabdomyolysis (Muscle Breakdown)
Specialty: Trauma and Injuries
Category: Soft Tissue Injuries
Sub-category: Crush Injuries
Symptoms:
muscle pain; weakness; swelling; dark or tea-colored urine; fatigue; nausea; vomiting
Root Cause:
Breakdown of muscle tissue leads to the release of intracellular contents, including myoglobin, creatine kinase, and electrolytes, into the bloodstream, potentially causing kidney damage.
How it's Diagnosed: videos
Blood tests showing elevated creatine kinase (CK) levels, myoglobin in urine, electrolyte imbalances (hyperkalemia, hypocalcemia), and renal function tests.
Treatment:
Aggressive intravenous fluid resuscitation to prevent kidney damage, electrolyte correction, and, in severe cases, dialysis or fasciotomy.
Medications:
Medications for rhabdomyolysis may include sodium bicarbonate (to alkalinize urine), diuretics (to support urine output), and calcium gluconate (to manage hyperkalemia). These belong to classes such as alkalizing agents, diuretics, and electrolyte replacements.
Prevalence:
How common the health condition is within a specific population.
Occurs in 26,000 cases per year in the U.S.; common causes include trauma, overexertion, and drug toxicity.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Trauma, crush injuries, prolonged immobility, intense exercise, dehydration, statin use, and drug or alcohol abuse.
Prognosis:
The expected outcome or course of the condition over time.
Good with early treatment; delayed intervention may lead to acute kidney injury or death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Acute kidney injury, electrolyte imbalances, compartment syndrome, cardiac arrhythmias, disseminated intravascular coagulation (DIC).
Metabolic Acidosis
Specialty: Nephrology
Category: Acid-Base Disorders
Symptoms:
rapid breathing (kussmaul respirations); fatigue; confusion; headache; nausea; vomiting; low blood pressure in severe cases
Root Cause:
Accumulation of acid or loss of bicarbonate in the body due to kidney dysfunction, increased acid production, or bicarbonate loss.
How it's Diagnosed: videos
Blood gas analysis (low pH, low bicarbonate), anion gap calculation, and electrolyte tests.
Treatment:
Address the underlying cause (e.g., correcting lactic acidosis or ketoacidosis), bicarbonate therapy in severe cases, and supportive care.
Medications:
Sodium bicarbonate (buffer agent), dichloroacetate (used experimentally in certain types of metabolic acidosis).
Prevalence:
How common the health condition is within a specific population.
Common in hospitalized patients, particularly those in critical care settings.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Chronic kidney disease, diabetes (ketoacidosis), sepsis, and diarrhea.
Prognosis:
The expected outcome or course of the condition over time.
Dependent on the underlying cause; prompt treatment generally leads to a favorable outcome.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Cardiac arrhythmias, shock, and multiorgan failure if untreated.
Pyelonephritis (Acute and Chronic)
Specialty: Nephrology
Category: Infections and Infectious Conditions
Symptoms:
fever; chills; flank pain; nausea; vomiting; painful urination; frequent urination; cloudy or foul-smelling urine; fatigue
Root Cause:
Infection of the kidney, often caused by ascending bacterial infection from the bladder, typically due to E. coli or other uropathogens.
How it's Diagnosed: videos
Urinalysis (showing pyuria, bacteriuria, hematuria), urine culture, blood tests (e.g., elevated white blood cell count), imaging studies (e.g., ultrasound or CT scan if complications are suspected).
Treatment:
Antibiotics are the primary treatment. Severe cases may require hospitalization for intravenous antibiotics and supportive care. Chronic pyelonephritis may need surgical correction of underlying anatomical issues.
Medications:
Acute cases
Prevalence:
How common the health condition is within a specific population.
Common in sexually active women, with higher rates in those with recurrent urinary tract infections. Chronic cases are rare and often associated with anatomical abnormalities or obstruction.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Female gender, pregnancy, recurrent UTIs, diabetes, urinary tract obstruction, vesicoureteral reflux, catheterization.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with timely treatment; chronic cases may lead to kidney scarring and impaired function.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Sepsis, renal abscesses, chronic kidney disease, hypertension.
HELLP Syndrome
Specialty: Nephrology
Category: Other Renal-Associated Conditions
Sub-category: Pregnancy-Related Kidney Conditions
Symptoms:
right upper abdominal pain; nausea; vomiting; headache; swelling; high blood pressure; fatigue; visual disturbances
Root Cause:
Severe form of preeclampsia characterized by hemolysis (H), elevated liver enzymes (EL), and low platelet count (LP). It reflects systemic endothelial dysfunction and microangiopathy.
How it's Diagnosed: videos
Blood tests showing hemolysis (schistocytes on blood smear), elevated liver enzymes (AST/ALT), low platelet count (<100,000/µL), and signs of end-organ damage; urine tests for proteinuria; imaging if indicated.
Treatment:
Delivery of the baby as the definitive treatment; supportive care with blood pressure management, magnesium sulfate for seizure prevention, and transfusions (platelets, red blood cells) if necessary.
Medications:
Antihypertensives such as labetalol or nifedipine , magnesium sulfate (anticonvulsant), and corticosteroids (e.g., dexamethasone ) to improve platelet count and fetal lung maturity.
Prevalence:
How common the health condition is within a specific population.
Occurs in approximately 0.5-0.9% of pregnancies, often associated with severe preeclampsia.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
History of preeclampsia, multiple pregnancies, obesity, pre-existing hypertension, or autoimmune disorders.
Prognosis:
The expected outcome or course of the condition over time.
Favorable with prompt delivery and management; however, maternal and fetal morbidity or mortality risk is higher without early intervention.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Disseminated intravascular coagulation (DIC), liver rupture, kidney failure, stroke, placental abruption, preterm delivery, or maternal and fetal death.
Gastric (Stomach) Cancer
Specialty: Oncology
Category: Solid Tumors
Sub-category: Gastrointestinal Cancers
Symptoms:
abdominal pain or discomfort; nausea; vomiting; loss of appetite; unintended weight loss; bloating; heartburn; melena (black, tarry stools); anemia
Root Cause:
Malignant growth in the stomach lining, often linked to Helicobacter pylori infection, chronic gastritis, or genetic predisposition.
How it's Diagnosed: videos
Upper endoscopy with biopsy, barium swallow, imaging (CT scan, PET scan), and staging laparoscopy in some cases.
Treatment:
Treatment involves surgery (total or partial gastrectomy), chemotherapy, radiation therapy, targeted therapy, or immunotherapy.
Medications:
Medications include chemotherapy agents like fluorouracil , oxaliplatin , and capecitabine ; targeted drugs like trastuzumab (HER2-positive tumors) or ramucirumab (anti-VEGFR2); and immunotherapy like nivolumab (anti-PD-1).
Prevalence:
How common the health condition is within a specific population.
Approximately 26,000 cases diagnosed annually in the United States; more common in East Asia, Eastern Europe, and South America.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
H. pylori infection, smoking, high salt intake, diets low in fruits and vegetables, family history, and obesity.
Prognosis:
The expected outcome or course of the condition over time.
Prognosis depends on stage; 5-year survival is about 70% for early-stage cancer but less than 30% for advanced disease.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Metastasis, gastrointestinal bleeding, bowel obstruction, or malnutrition following surgery.
Gallbladder Cancer
Specialty: Oncology
Category: Solid Tumors
Sub-category: Gastrointestinal Cancers
Symptoms:
abdominal pain, especially in the upper right quadrant; jaundice; nausea; vomiting; unintended weight loss; loss of appetite; abdominal swelling; fever
Root Cause:
Malignant tumors originating in the gallbladder, often linked to chronic inflammation, gallstones, or genetic mutations.
How it's Diagnosed: videos
Imaging (ultrasound, CT, or MRI), endoscopic retrograde cholangiopancreatography (ERCP), and biopsy.
Treatment:
Treatment includes surgical resection (cholecystectomy), chemotherapy, radiation therapy, and occasionally targeted therapy.
Medications:
Chemotherapy drugs like gemcitabine and cisplatin are commonly used; targeted therapies are being explored in clinical trials.
Prevalence:
How common the health condition is within a specific population.
Rare; approximately 12,000 cases diagnosed annually in the United States, with higher prevalence in South America and Southeast Asia.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Gallstones, chronic cholecystitis, obesity, older age, female gender, and a history of bile duct abnormalities.
Prognosis:
The expected outcome or course of the condition over time.
Prognosis depends on the stage at diagnosis; 5-year survival is about 65% for localized cancer but less than 10% for advanced stages.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Biliary obstruction, liver metastasis, and malnutrition.
Gastrointestinal Stromal Tumor (GIST)
Specialty: Oncology
Category: Solid Tumors
Sub-category: Gastrointestinal Cancers
Symptoms:
abdominal pain; nausea; vomiting; gastrointestinal bleeding; unintended weight loss; anemia; abdominal swelling
Root Cause:
Rare mesenchymal tumors arising from interstitial cells of Cajal in the gastrointestinal tract, often caused by mutations in the KIT or PDGFRA genes.
How it's Diagnosed: videos
Imaging (CT or MRI), endoscopy with biopsy, and molecular testing for KIT or PDGFRA mutations.
Treatment:
Surgery is the primary treatment for localized tumors; systemic therapy is used for advanced or metastatic cases.
Medications:
Targeted therapy with imatinib (tyrosine kinase inhibitor) is the first-line treatment; sunitinib and regorafenib are used for resistant or advanced cases.
Prevalence:
How common the health condition is within a specific population.
Very rare, with an incidence of 4,000-6,000 cases annually in the United States.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
No strong environmental risk factors; some cases are linked to genetic syndromes like neurofibromatosis type 1.
Prognosis:
The expected outcome or course of the condition over time.
Excellent for localized tumors treated surgically; 5-year survival rate for metastatic disease is about 50% with effective targeted therapy.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Tumor rupture leading to peritonitis, metastasis (commonly to the liver), and recurrence.
Medulloblastoma
Specialty: Oncology
Category: Sarcomas
Sub-category: Pediatric Cancers
Symptoms:
headaches; vomiting; balance problems; vision problems; personality changes; clumsiness
Root Cause:
Malignant tumor in the cerebellum (part of the brain), which affects balance, motor control, and coordination.
How it's Diagnosed: videos
MRI, CT scan, biopsy, cerebrospinal fluid analysis.
Treatment:
Surgery, radiation therapy, chemotherapy.
Medications:
Chemotherapy drugs like cisplatin , vincristine , cyclophosphamide , carboplatin ; corticosteroids for swelling.
Prevalence:
How common the health condition is within a specific population.
Accounts for 20% of all brain tumors in children, with around 350 cases annually in the U.S.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Genetic conditions (e.g., Gorlin syndrome), prior radiation exposure.
Prognosis:
The expected outcome or course of the condition over time.
Survival rate is about 70% for localized cases, but much lower for metastatic disease.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Neurological impairments, growth problems, cognitive and motor deficits, secondary cancers due to radiation.
Small Intestine Cancer
Specialty: Oncology
Category: Sarcomas
Sub-category: Rare Cancers
Symptoms:
abdominal pain; unexplained weight loss; nausea; vomiting; jaundice; blood in stool; changes in bowel habits; fatigue
Root Cause:
Small intestine cancer develops in the cells of the small intestine, often affecting the epithelial or neuroendocrine cells. The exact cause is unknown, but genetic mutations and conditions like Crohn's disease, celiac disease, and Lynch syndrome can increase the risk.
How it's Diagnosed: videos
Diagnosis is typically through imaging studies like CT scans, MRIs, or endoscopy (e.g., capsule endoscopy or push enteroscopy). Biopsy is used to confirm the diagnosis through histological examination of the tumor tissue.
Treatment:
Treatment involves surgery to remove the tumor if detected early. Chemotherapy (e.g., 5-fluorouracil, capecitabine, or oxaliplatin) is often used for advanced disease. Radiation therapy may be used in some cases. Targeted therapy or immunotherapy may also be considered depending on tumor type.
Medications:
Chemotherapy drugs like 5-fluorouracil (an antimetabolite) and oxaliplatin (a platinum-based chemotherapy drug) are commonly used. Targeted therapies like bevacizumab (an anti-VEGF monoclonal antibody) and immunotherapies such as pembrolizumab (an immune checkpoint inhibitor) may be prescribed for advanced or metastatic cases.
Prevalence:
How common the health condition is within a specific population.
Small intestine cancer is very rare, representing less than 2% of all gastrointestinal cancers. Its incidence is estimated to be about 2-3 cases per 100,000 people per year.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Risk factors include genetic conditions such as Lynch syndrome, familial adenomatous polyposis (FAP), and Crohn's disease. Celiac disease and a history of radiation therapy to the abdomen also increase risk.
Prognosis:
The expected outcome or course of the condition over time.
The prognosis depends on the stage of the cancer at diagnosis. For localized small intestine cancer, the 5-year survival rate can be as high as 80%, while for metastatic disease, the prognosis is much poorer, with a 5-year survival rate closer to 30%.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Potential complications include bowel obstruction, bleeding, malnutrition, and metastasis to the liver or lymph nodes. In some cases, the cancer can lead to the development of secondary tumors or complications from chemotherapy.
Peritoneal Mesothelioma
Specialty: Oncology
Category: Sarcomas
Sub-category: Rare Cancers
Symptoms:
abdominal pain; swelling in the abdomen; unexplained weight loss; nausea; vomiting; loss of appetite; fatigue; bloating; constipation
Root Cause:
Peritoneal mesothelioma is a rare cancer that affects the peritoneum, the lining of the abdomen. It is most commonly caused by asbestos exposure, which leads to the development of malignant cells that grow and invade the peritoneal lining.
How it's Diagnosed: videos
Diagnosis typically involves imaging studies such as CT scans, MRIs, or ultrasounds to detect fluid buildup (ascites) and tumors in the abdomen. A biopsy is needed for definitive diagnosis, often performed through laparoscopy or peritoneal biopsy.
Treatment:
Treatment options include surgery (e.g., cytoreductive surgery) to remove as much of the tumor as possible, often followed by heated chemotherapy (HIPEC) to target remaining cancer cells. Chemotherapy (e.g., pemetrexed and cisplatin) is used for advanced cases, and radiation therapy may also be applied.
Medications:
Common chemotherapy drugs used to treat peritoneal mesothelioma include pemetrexed (an antifolate drug) and cisplatin (a platinum-based chemotherapy agent). These are used in combination to help shrink tumors and manage the disease. In some cases, targeted therapies or immunotherapy may be considered.
Prevalence:
How common the health condition is within a specific population.
Peritoneal mesothelioma is extremely rare, accounting for approximately 10-20% of all mesothelioma cases. The overall incidence is low, with an estimated 300-500 new cases diagnosed annually in the United States.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
The primary risk factor is exposure to asbestos, particularly in occupations like construction, shipbuilding, and manufacturing. Other risk factors include genetic mutations and a history of prior radiation exposure.
Prognosis:
The expected outcome or course of the condition over time.
The prognosis for peritoneal mesothelioma is poor, with a median survival rate of 12-24 months, depending on the stage at diagnosis. Patients who undergo cytoreductive surgery with HIPEC may have improved outcomes, but survival is still limited.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Complications include bowel obstruction, ascites (fluid buildup in the abdomen), malnutrition, and metastasis to other parts of the body, particularly the lungs. The treatment itself can also cause side effects like fatigue, nausea, and immune suppression.
Hypercalcemia of Malignancy
Specialty: Oncology
Category: Sarcomas
Sub-category: Paraneoplastic Syndromes
Symptoms:
nausea; vomiting; constipation; abdominal pain; fatigue; confusion; thirst; frequent urination; muscle weakness
Root Cause:
Malignant tumors release calcium into the bloodstream, often through secretion of parathyroid hormone-related protein (PTHrP) or osteolytic bone metastasis.
How it's Diagnosed: videos
Blood tests showing elevated calcium levels, alongside confirmation of underlying malignancy through imaging or biopsy.
Treatment:
Hydration, bisphosphonates (such as zoledronic acid), denosumab, corticosteroids, and calcitonin.
Medications:
Bisphosphonates (e.g., zoledronic acid) inhibit bone resorption, and denosumab , a monoclonal antibody, works by inhibiting osteoclast activity. Corticosteroids (e.g., dexamethasone ) may be used if there is an underlying hematologic malignancy. Calcitonin helps to lower calcium levels by inhibiting osteoclast function.
Prevalence:
How common the health condition is within a specific population.
Affects approximately 10-20% of patients with advanced cancer.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Patients with lung, breast, or hematologic cancers, and those with extensive bone metastasis.
Prognosis:
The expected outcome or course of the condition over time.
The prognosis depends on the underlying malignancy and the ability to control calcium levels. Treatment of the underlying cancer can improve the prognosis.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Severe hypercalcemia can cause kidney failure, arrhythmias, coma, and, if untreated, death.
Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH)
Specialty: Oncology
Category: Sarcomas
Sub-category: Paraneoplastic Syndromes
Symptoms:
hyponatremia; nausea; vomiting; confusion; seizures; lethargy; muscle cramps
Root Cause:
Tumors produce excess antidiuretic hormone (ADH), leading to water retention and dilutional hyponatremia.
How it's Diagnosed: videos
Blood tests showing low sodium levels and high urine osmolality despite low serum osmolality. Imaging to identify the tumor may also be necessary.
Treatment:
Fluid restriction, hypertonic saline in severe cases, and vasopressin receptor antagonists (e.g., tolvaptan). Treating the underlying cancer may improve SIADH.
Medications:
Vasopressin receptor antagonists (e.g., tolvaptan ) help correct sodium imbalances by blocking the effects of ADH.
Prevalence:
How common the health condition is within a specific population.
Common in patients with small cell lung cancer, as well as other malignancies like head and neck cancers.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Small cell lung cancer, brain tumors, and medications such as cyclophosphamide or vincristine.
Prognosis:
The expected outcome or course of the condition over time.
Prognosis depends on the underlying malignancy and successful management of fluid imbalances.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
If untreated, SIADH can lead to severe hyponatremia, seizures, and coma.
Neuromyelitis Optica (Anti-Aquaporin-4 Antibody Syndrome)
Specialty: Oncology
Category: Sarcomas
Sub-category: Paraneoplastic Syndromes
Symptoms:
vision loss; optic neuritis; nausea; vomiting; paralysis; sensory disturbances; bladder dysfunction; extreme fatigue
Root Cause:
Autoimmune response against aquaporin-4 channels on astrocytes, causing inflammation of the optic nerve and spinal cord, often associated with malignancies.
How it's Diagnosed: videos
Detection of anti-AQP4 antibodies in the blood, MRI showing spinal cord and optic nerve lesions, and clinical presentation.
Treatment:
High-dose corticosteroids, plasmapheresis, and rituximab (an immunosuppressive therapy).
Medications:
Corticosteroids (e.g., methylprednisolone ), rituximab (a monoclonal antibody), and plasmapheresis may be used to manage acute relapses.
Prevalence:
How common the health condition is within a specific population.
Rare, with an estimated 2-4 cases per million people annually.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Associated with autoimmune diseases, and may be paraneoplastic in some cases linked to cancers such as breast, lung, and ovarian.
Prognosis:
The expected outcome or course of the condition over time.
Relapsing-remitting course in some patients; poor prognosis with significant long-term disability if untreated.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Vision loss, paralysis, and in severe cases, respiratory failure due to spinal cord involvement.
Acute Intermittent Porphyria (AIP)
Specialty: Hematology
Category: Heme Synthesis and Disorders
Symptoms:
abdominal pain; nausea; vomiting; constipation; muscle weakness; confusion; anxiety; seizures; dark-colored urine
Root Cause:
Deficiency of the enzyme porphobilinogen deaminase (PBGD), leading to the accumulation of heme precursors such as delta-aminolevulinic acid (ALA) and porphobilinogen (PBG).
How it's Diagnosed: videos
Measurement of urinary porphobilinogen (PBG) levels during an acute attack; genetic testing to confirm enzyme mutations.
Treatment:
Avoiding triggers (e.g., certain drugs, fasting, stress), intravenous administration of hemin, high carbohydrate intake during attacks.
Medications:
Hemin (a heme analog used to suppress heme synthesis); glucose infusions for mild attacks to inhibit ALA synthase.
Prevalence:
How common the health condition is within a specific population.
Affects approximately 1 in 20,000 individuals; more common in women than men.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Female sex, hormonal fluctuations, certain medications (e.g., barbiturates, sulfa drugs), fasting, alcohol consumption.
Prognosis:
The expected outcome or course of the condition over time.
With proper management, acute attacks are treatable; however, untreated attacks can lead to complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Permanent neurological damage, chronic pain, liver cancer (in rare cases).
ALA Dehydratase Deficiency Porphyria (ALADP)
Specialty: Hematology
Category: Heme Synthesis and Disorders
Symptoms:
severe abdominal pain; nausea; vomiting; neuropathy; weakness; dark-colored urine
Root Cause:
Deficiency of the enzyme ALA dehydratase, resulting in elevated levels of ALA in the plasma and urine.
How it's Diagnosed: videos
Elevated urinary ALA levels, enzyme assays showing low ALA dehydratase activity, genetic testing.
Treatment:
Hemin administration, carbohydrate loading, and avoidance of triggers.
Medications:
Hemin (to downregulate ALA production); glucose infusions for supportive management.
Prevalence:
How common the health condition is within a specific population.
Extremely rare, with fewer than 10 reported cases worldwide.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Genetic mutations, exposure to heavy metals (e.g., lead poisoning).
Prognosis:
The expected outcome or course of the condition over time.
Chronic management is required to prevent acute attacks; outcomes depend on the severity and frequency of symptoms.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Neurological deficits, kidney damage.
Hereditary Coproporphyria (HCP)
Specialty: Hematology
Category: Heme Synthesis and Disorders
Symptoms:
abdominal pain; nausea; vomiting; neuropathy; photosensitivity; dark urine
Root Cause:
Deficiency of the enzyme coproporphyrinogen oxidase, leading to the accumulation of porphyrins in the liver and plasma.
How it's Diagnosed: videos
Elevated levels of coproporphyrins in urine and stool; genetic testing.
Treatment:
Avoiding triggers, administration of hemin for acute attacks, high carbohydrate intake during symptomatic episodes.
Medications:
Hemin (to inhibit ALA synthase); glucose infusions for mild attacks.
Prevalence:
How common the health condition is within a specific population.
Rare, with a prevalence of approximately 1 in 1,000,000.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Family history, hormonal changes, fasting, certain medications (e.g., sulfonamides).
Prognosis:
The expected outcome or course of the condition over time.
Treatable; acute episodes can be effectively managed.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Neurological damage, chronic pain, photosensitivity-related skin damage.
Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episodes (MELAS)
Specialty: Genetics
Category: Single-Gene Disorders (Mendelian Inheritance)
Sub-category: Mitochondrial Disorders
Symptoms:
muscle weakness; recurrent headaches; vomiting; seizures; stroke-like episodes before age 40; hearing loss; diabetes mellitus; vision loss; cognitive decline
Root Cause:
Mutations in mitochondrial DNA (mtDNA) impair energy production in cells by affecting oxidative phosphorylation.
How it's Diagnosed: videos
Clinical assessment, brain MRI showing stroke-like lesions, muscle biopsy with ragged red fibers, and genetic testing for mtDNA mutations.
Treatment:
Symptomatic management with physical therapy, occupational therapy, and dietary supplementation (e.g., L-arginine, coenzyme Q10). Stroke prevention strategies may include arginine supplementation during acute episodes.
Medications:
No specific FDA-approved medications for MELAS; however, supplements like L-arginine and coenzyme Q10 (antioxidants and mitochondrial support therapies) are often recommended. Anticonvulsants may be prescribed for seizures (e.g., levetiracetam , a broad-spectrum anticonvulsant).
Prevalence:
How common the health condition is within a specific population.
Rare, with an estimated prevalence of 1 in 10,000 to 1 in 20,000 individuals worldwide.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Family history of mitochondrial disorders, maternally inherited mtDNA mutations.
Prognosis:
The expected outcome or course of the condition over time.
Progressive disorder with varying severity; life expectancy depends on the severity of symptoms and complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Stroke-like episodes, seizures, hearing loss, progressive neurological decline, diabetes mellitus, and cardiomyopathy.
Maple syrup urine disease
Specialty: Genetics
Category: Metabolic and Storage Disorders
Sub-category: Inborn Errors of Metabolism
Symptoms:
sweet-smelling urine; poor feeding; vomiting; lethargy; developmental delay; seizures; ketoacidosis; hypotonia
Root Cause:
Deficiency in branched-chain alpha-keto acid dehydrogenase complex, leading to the accumulation of leucine, isoleucine, and valine in the blood and tissues.
How it's Diagnosed: videos
Newborn screening, plasma amino acid analysis showing elevated branched-chain amino acids, genetic testing for mutations in BCKDHA, BCKDHB, or DBT genes.
Treatment:
Dietary restriction of branched-chain amino acids (leucine, isoleucine, valine), supplementation with a specialized medical formula, and emergency intervention during metabolic crises with intravenous fluids and glucose.
Medications:
Thiamine (a cofactor for the defective enzyme) may be tried in thiamine-responsive forms of MSUD.
Prevalence:
How common the health condition is within a specific population.
Rare, affecting approximately 1 in 185,000 newborns worldwide.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Consanguinity, family history of MSUD, genetic inheritance in an autosomal recessive pattern.
Prognosis:
The expected outcome or course of the condition over time.
Favorable with early diagnosis and strict metabolic control; without treatment, severe neurologic damage or death can occur.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Intellectual disability, neurological crises, coma, metabolic acidosis, and death in untreated cases.
Galactosemia
Specialty: Genetics
Category: Metabolic and Storage Disorders
Sub-category: Inborn Errors of Metabolism
Symptoms:
jaundice; vomiting; diarrhea; poor feeding; failure to thrive; lethargy; sepsis; cataracts
Root Cause:
Deficiency of the enzyme galactose-1-phosphate uridylyltransferase (GALT), leading to toxic accumulation of galactose-1-phosphate and galactose.
How it's Diagnosed: videos
Newborn screening, measuring GALT enzyme activity in red blood cells, genetic testing, and elevated galactose-1-phosphate levels in blood.
Treatment:
Lifelong dietary restriction of galactose by avoiding lactose-containing foods (e.g., milk, dairy).
Medications:
No specific medications; dietary management is the mainstay of treatment.
Prevalence:
How common the health condition is within a specific population.
Approximately 1 in 30,000 to 60,000 live births.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Family history, autosomal recessive inheritance.
Prognosis:
The expected outcome or course of the condition over time.
Good with early dietary management, but long-term complications like learning disabilities and ovarian insufficiency are possible.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Intellectual disability, liver failure, sepsis, and death in untreated cases.
Urea Cycle Disorders (e.g., Ornithine Transcarbamylase Deficiency)
Specialty: Genetics
Category: Metabolic and Storage Disorders
Sub-category: Inborn Errors of Metabolism
Symptoms:
hyperammonemia; lethargy; vomiting; poor feeding; irritability; coma; developmental delay
Root Cause:
Defects in enzymes of the urea cycle result in impaired ammonia detoxification and hyperammonemia.
How it's Diagnosed: videos
Plasma ammonia levels, plasma amino acid analysis (elevated glutamine, low citrulline), urinary orotic acid, and genetic testing for specific enzyme mutations.
Treatment:
Protein-restricted diet, ammonia-scavenging drugs, liver transplantation in severe cases.
Medications:
Sodium phenylbutyrate or glycerol phenylbutyrate (ammonia scavengers), arginine or citrulline supplements depending on the enzyme deficiency.
Prevalence:
How common the health condition is within a specific population.
Approximately 1 in 35,000 live births.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Family history, X-linked or autosomal recessive inheritance patterns.
Prognosis:
The expected outcome or course of the condition over time.
Good with early intervention and metabolic control; severe cases may require liver transplantation.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Intellectual disability, seizures, coma, and death due to hyperammonemia.
Acetaminophen (Paracetamol) Toxicity
Specialty: Toxicology
Category: Acute Poisoning
Sub-category: Pharmaceutical Overdoses
Symptoms:
nausea; vomiting; abdominal pain; jaundice; confusion; fatigue
Root Cause:
Excessive intake of acetaminophen overwhelms liver detoxification pathways, leading to toxic accumulation of N-acetyl-p-benzoquinone imine (NAPQI), a metabolite that causes liver damage.
How it's Diagnosed: videos
Diagnosed with serum acetaminophen levels and liver function tests.
Treatment:
Treated with N-acetylcysteine (NAC) to replenish glutathione and prevent liver damage.
Medications:
N-acetylcysteine (NAC) is the antidote for acetaminophen toxicity. It belongs to the class of mucolytics and glutathione precursors.
Prevalence:
How common the health condition is within a specific population.
Acetaminophen toxicity is one of the most common causes of acute liver failure globally, with thousands of cases reported annually.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Overdose (intentional or accidental), chronic alcohol use, malnutrition, or concurrent use of medications that induce cytochrome P450 enzymes (e.g., certain anticonvulsants).
Prognosis:
The expected outcome or course of the condition over time.
Good if treated promptly; severe cases can lead to acute liver failure and death if untreated.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Acute liver failure, hepatic encephalopathy, kidney injury, and death in severe cases.
Aspirin (Salicylate) Poisoning
Specialty: Toxicology
Category: Acute Poisoning
Sub-category: Pharmaceutical Overdoses
Symptoms:
nausea; vomiting; hyperventilation; ringing in the ears (tinnitus); confusion; seizures; coma
Root Cause:
Excessive salicylates disrupt metabolic pathways, causing respiratory alkalosis, metabolic acidosis, and increased energy expenditure.
How it's Diagnosed: videos
Diagnosed by serum salicylate levels and blood gas analysis
Treatment:
Treated with activated charcoal, IV sodium bicarbonate for alkalinization, and hemodialysis in severe cases.
Medications:
Sodium bicarbonate is used to alkalinize urine; it is an alkalinizing agent. No specific antidote exists.
Prevalence:
How common the health condition is within a specific population.
Less common due to decreased aspirin use in children but still a concern in adults and intentional overdoses.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Intentional overdose, chronic use, impaired kidney function, or co-ingestion with other medications.
Prognosis:
The expected outcome or course of the condition over time.
Good with early treatment; severe cases can result in multi-organ failure and death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Pulmonary edema, cerebral edema, seizures, and renal failure.
Organophosphate and carbamate insecticide poisoning
Specialty: Toxicology
Category: Acute Poisoning
Sub-category: Chemical Poisoning
Symptoms:
nausea; vomiting; diarrhea; salivation; lacrimation (tearing); urination; muscle twitching; confusion; seizures; respiratory distress; bradycardia; miosis (pupil constriction)
Root Cause:
Inhibition of acetylcholinesterase enzyme, leading to an accumulation of acetylcholine at synapses and overstimulation of the nervous system.
How it's Diagnosed: videos
Clinical history of exposure, symptoms presentation, blood cholinesterase levels (low levels indicate poisoning).
Treatment:
Decontamination (removal of contaminated clothing, washing skin), administration of atropine (to counteract muscarinic effects) and pralidoxime (to reactivate acetylcholinesterase), supportive care (oxygen, fluids).
Medications:
Atropine (anticholinergic agent), pralidoxime (cholinesterase reactivator), benzodiazepines (e.g., diazepam or lorazepam ) for seizures.
Prevalence:
How common the health condition is within a specific population.
Common in agricultural regions where these insecticides are widely used; estimated to cause hundreds of thousands of poisonings annually worldwide.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Occupational exposure (farmers, pesticide applicators), improper storage or handling, intentional ingestion (suicide attempt).
Prognosis:
The expected outcome or course of the condition over time.
Favorable with prompt treatment; delayed treatment can lead to severe complications or death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Respiratory failure, prolonged muscle weakness (intermediate syndrome), long-term neurological dysfunction.
Methanol and ethylene glycol poisoning
Specialty: Toxicology
Category: Acute Poisoning
Sub-category: Chemical Poisoning
Symptoms:
nausea; vomiting; abdominal pain; blurred vision; seizures; altered mental status; metabolic acidosis; renal failure
Root Cause:
Toxic metabolites (formic acid from methanol, oxalate crystals from ethylene glycol) cause metabolic acidosis and organ damage (e.g., optic nerve in methanol poisoning, kidneys in ethylene glycol poisoning).
How it's Diagnosed: videos
Clinical history, elevated anion gap metabolic acidosis, osmolar gap, specific blood levels of methanol or ethylene glycol.
Treatment:
Administration of fomepizole or ethanol (inhibits alcohol dehydrogenase), bicarbonate therapy for acidosis, hemodialysis for severe cases, folinic acid or pyridoxine (cofactors to detoxify metabolites).
Medications:
Fomepizole (alcohol dehydrogenase inhibitor), ethanol (alternative alcohol dehydrogenase substrate), bicarbonate (neutralizes acidosis), folinic acid (enhances formic acid detoxification in methanol poisoning).
Prevalence:
How common the health condition is within a specific population.
Sporadic cases, commonly associated with accidental ingestion or intentional poisoning.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Ingestion of antifreeze, windshield washer fluid, or contaminated alcohol.
Prognosis:
The expected outcome or course of the condition over time.
Good with early treatment; delays can lead to permanent blindness or renal damage.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Blindness (methanol), renal failure (ethylene glycol), metabolic acidosis, multi-organ failure.
Carbon monoxide poisoning
Specialty: Toxicology
Category: Acute Poisoning
Sub-category: Chemical Poisoning
Symptoms:
headache; dizziness; nausea; vomiting; confusion; chest pain; shortness of breath; loss of consciousness; seizures; coma
Root Cause:
Carbon monoxide binds to hemoglobin with greater affinity than oxygen, forming carboxyhemoglobin, which reduces oxygen delivery to tissues and causes cellular hypoxia.
How it's Diagnosed: videos
Clinical history, carboxyhemoglobin levels via blood gas analysis, pulse CO-oximetry (if available).
Treatment:
Removal from exposure source, administration of 100% oxygen, hyperbaric oxygen therapy in severe cases.
Medications:
No specific medications; 100% oxygen or hyperbaric oxygen therapy is the treatment of choice.
Prevalence:
How common the health condition is within a specific population.
Common, particularly in poorly ventilated areas with gas heaters, car exhaust, or during fire incidents.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Indoor use of gas appliances, fires, motor vehicle exhaust, faulty heating systems.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with early treatment; delayed treatment can result in neurological sequelae or death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Hypoxic brain injury, delayed neuropsychiatric syndrome (DNS), arrhythmias, myocardial ischemia.
Hydrofluoric acid toxicity
Specialty: Toxicology
Category: Acute Poisoning
Sub-category: Chemical Poisoning
Symptoms:
severe pain at the exposure site; redness or whitish discoloration of the skin; swelling; nausea; vomiting; cardiac arrhythmias; hypocalcemia; muscle spasms; weakness
Root Cause:
Hydrofluoric acid penetrates tissues deeply, dissociating into hydrogen and fluoride ions. The fluoride ions bind calcium and magnesium, disrupting cellular function and leading to systemic toxicity.
How it's Diagnosed: videos
Clinical history of exposure, symptoms presentation, serum calcium, magnesium, and potassium levels, ECG (to detect arrhythmias).
Treatment:
Immediate washing of the skin with water, application of calcium gluconate gel to neutralize fluoride ions, intravenous calcium gluconate for systemic toxicity, supportive care.
Medications:
Calcium gluconate (topical and intravenous), magnesium supplements, pain relievers (e.g., opioids for severe pain).
Prevalence:
How common the health condition is within a specific population.
Rare, typically associated with industrial settings or accidental exposure.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Industrial exposure (e.g., glass etching, rust removal, cleaning agents), inadequate safety measures.
Prognosis:
The expected outcome or course of the condition over time.
Good with prompt treatment; severe exposure can result in systemic toxicity or death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Hypocalcemia, hyperkalemia, cardiac arrhythmias, tissue necrosis, systemic toxicity.
Chlorine gas exposure
Specialty: Toxicology
Category: Acute Poisoning
Sub-category: Chemical Poisoning
Symptoms:
coughing; shortness of breath; chest tightness; burning sensation in the throat and eyes; wheezing; nausea; vomiting; pulmonary edema
Root Cause:
Chlorine gas reacts with water in the respiratory tract to form hydrochloric acid and hypochlorous acid, causing irritation and damage to respiratory tissues.
How it's Diagnosed: videos
Clinical history of exposure, symptoms presentation, chest X-ray or CT scan to assess lung damage.
Treatment:
Removal from exposure, supportive care with oxygen therapy, bronchodilators for wheezing, corticosteroids for severe inflammation.
Medications:
Bronchodilators (e.g., albuterol ), corticosteroids (e.g., prednisone ), oxygen therapy.
Prevalence:
How common the health condition is within a specific population.
Sporadic cases, often associated with industrial accidents or improper mixing of cleaning agents.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Industrial exposure, household accidents, swimming pool maintenance (chlorine release).
Prognosis:
The expected outcome or course of the condition over time.
Good with early treatment; severe exposure can lead to chronic respiratory issues.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Reactive airway dysfunction syndrome (RADS), chronic bronchitis, pulmonary edema.
Synthetic cannabinoids toxicity
Specialty: Toxicology
Category: Acute Poisoning
Sub-category: Chemical Poisoning
Symptoms:
confusion; anxiety; paranoia; seizures; hypertension; nausea; vomiting; chest pain
Root Cause:
Overactivation of cannabinoid receptors by synthetic chemicals, leading to unpredictable and exaggerated physiological and psychological effects.
How it's Diagnosed: videos
History of synthetic cannabinoid use, clinical symptoms, and toxicology testing (though specific detection is often limited).
Treatment:
Supportive care, benzodiazepines for agitation or seizures, antiemetics for nausea, and cardiovascular monitoring.
Medications:
Benzodiazepines (e.g., lorazepam ) for agitation and seizures; antiemetics like ondansetron for nausea and vomiting.
Prevalence:
How common the health condition is within a specific population.
Increasingly reported due to the availability of synthetic cannabinoids as a legal alternative to cannabis in some regions.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Use of synthetic cannabinoids, mixing with other substances, and lack of knowledge about the specific chemical consumed.
Prognosis:
The expected outcome or course of the condition over time.
Most cases resolve with supportive care, but severe toxicity can lead to life-threatening complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Acute kidney injury, seizures, psychosis, and cardiac arrhythmias.
Acute Alcohol Intoxication
Specialty: Toxicology
Category: Acute Poisoning
Sub-category: Alcohol-Related Toxicity
Symptoms:
slurred speech; impaired coordination; confusion; vomiting; stupor; respiratory depression; hypothermia; coma
Root Cause:
Central nervous system depression caused by excessive alcohol consumption leading to toxic blood alcohol concentrations.
How it's Diagnosed: videos
Clinical presentation (history and physical exam), measurement of blood alcohol concentration (BAC), and ruling out other causes of altered mental status.
Treatment:
Supportive care, airway management, oxygen if needed, intravenous fluids, correction of hypoglycemia, and monitoring for complications like aspiration or hypothermia.
Medications:
No specific antidote; thiamine (vitamin B1) is often administered to prevent Wernicke's encephalopathy in high-risk individuals.
Prevalence:
How common the health condition is within a specific population.
Common; affects millions globally, particularly in individuals who binge drink or have alcohol use disorders.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Excessive alcohol consumption, binge drinking, low body weight, underlying liver disease, concurrent use of sedatives or opioids.
Prognosis:
The expected outcome or course of the condition over time.
Typically resolves with prompt treatment; severe cases may lead to death if untreated.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Aspiration pneumonia, hypothermia, seizures, brain damage from hypoxia, and death.
Isopropanol Poisoning
Specialty: Toxicology
Category: Acute Poisoning
Sub-category: Alcohol-Related Toxicity
Symptoms:
drowsiness; vomiting; abdominal pain; fruity breath odor; hypotension; coma; respiratory depression
Root Cause:
Central nervous system and gastrointestinal toxicity caused by ingestion or inhalation of isopropanol, metabolized to acetone.
How it's Diagnosed: videos
Clinical history, serum isopropanol levels, elevated osmolal gap, and acetone presence in blood or urine.
Treatment:
Supportive care, intravenous fluids, airway protection, hemodialysis in severe cases.
Medications:
No antidote is available ; management focuses on supportive care and hemodialysis for severe toxicity.
Prevalence:
How common the health condition is within a specific population.
Rare; typically occurs due to accidental ingestion or intentional overdose.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Access to isopropanol (e.g., rubbing alcohol), substance misuse, occupational exposure.
Prognosis:
The expected outcome or course of the condition over time.
Generally good with prompt supportive care; severe cases can result in respiratory or cardiovascular failure.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Hemorrhagic gastritis, hypotension, multi-organ failure.
Methanol Poisoning
Specialty: Toxicology
Category: Acute Poisoning
Sub-category: Alcohol-Related Toxicity
Symptoms:
headache; nausea; vomiting; blurred vision; metabolic acidosis; confusion; seizures; blindness; coma
Root Cause:
Metabolism of methanol to formic acid leads to severe metabolic acidosis and optic nerve toxicity.
How it's Diagnosed: videos
Measurement of serum methanol levels, metabolic acidosis with increased anion and osmolal gap, and clinical symptoms.
Treatment:
Administration of fomepizole or ethanol to inhibit alcohol dehydrogenase, correction of acidosis with bicarbonate, and hemodialysis to remove methanol and formic acid.
Medications:
Fomepizole or ethanol (alcohol dehydrogenase inhibitors); sodium bicarbonate for acidosis.
Prevalence:
How common the health condition is within a specific population.
Rare; occurs due to ingestion of adulterated alcohol or industrial exposure.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Access to methanol-containing products, substance misuse, occupational hazards.
Prognosis:
The expected outcome or course of the condition over time.
With early treatment, prognosis is good; delayed treatment can result in blindness or death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Permanent blindness, multi-organ failure, death.
Ethylene Glycol Poisoning
Specialty: Toxicology
Category: Acute Poisoning
Sub-category: Alcohol-Related Toxicity
Symptoms:
nausea; vomiting; abdominal pain; metabolic acidosis; seizures; kidney failure; coma
Root Cause:
Metabolism of ethylene glycol to toxic metabolites (glycolic acid, oxalic acid) causes metabolic acidosis, renal toxicity, and crystalluria.
How it's Diagnosed: videos
Elevated anion and osmolal gap, presence of calcium oxalate crystals in urine, serum ethylene glycol levels.
Treatment:
Fomepizole or ethanol to inhibit alcohol dehydrogenase, bicarbonate for acidosis, and hemodialysis for severe poisoning.
Medications:
Fomepizole or ethanol (alcohol dehydrogenase inhibitors); pyridoxine and thiamine may support metabolism.
Prevalence:
How common the health condition is within a specific population.
Uncommon; typically involves accidental or intentional ingestion of antifreeze.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Access to ethylene glycol-containing products, substance misuse, occupational exposure.
Prognosis:
The expected outcome or course of the condition over time.
Good with early treatment; delayed or untreated cases often result in severe renal damage or death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Acute kidney injury, metabolic acidosis, neurological damage, death.
Arsenic Poisoning
Specialty: Toxicology
Category: Chronic Toxicity and Long-Term Exposures
Sub-category: Heavy Metal Toxicity
Symptoms:
nausea; vomiting; abdominal pain; diarrhea; darkened skin patches; thickened skin on palms and soles; fatigue; peripheral neuropathy; confusion; muscle cramps
Root Cause:
Accumulation of arsenic in the body due to exposure to contaminated drinking water, industrial processes, or arsenic-containing pesticides. Arsenic disrupts cellular metabolism, DNA repair, and oxidative processes.
How it's Diagnosed: videos
Diagnosis is made through urine arsenic levels (preferred for recent exposure) or hair and nail analysis for chronic exposure. Clinical symptoms and exposure history are also key.
Treatment:
Treatment includes cessation of exposure, supportive care for symptoms, and chelation therapy for severe cases. Ensuring access to safe water sources is critical.
Medications:
Chelating agents such as dimercaprol and succimer (DMSA) are used to bind arsenic and enhance excretion. The choice of medication depends on the severity of poisoning.
Prevalence:
How common the health condition is within a specific population.
Arsenic poisoning is prevalent in regions with contaminated groundwater, particularly in South Asia (e.g., Bangladesh, India) and parts of South America.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Drinking arsenic-contaminated water, occupational exposure (e.g., smelting, mining), use of arsenic-based pesticides, and ingestion of contaminated food.
Prognosis:
The expected outcome or course of the condition over time.
Early intervention and cessation of exposure can lead to symptom improvement. However, prolonged exposure can result in irreversible damage and increased cancer risk.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Long-term complications include skin lesions, peripheral neuropathy, cardiovascular diseases, diabetes, and increased risks of cancers (e.g., skin, lung, bladder).
Cadmium Poisoning
Specialty: Toxicology
Category: Chronic Toxicity and Long-Term Exposures
Sub-category: Heavy Metal Toxicity
Symptoms:
nausea; vomiting; abdominal pain; diarrhea; shortness of breath; cough; weakness; bone pain; renal dysfunction (proteinuria); osteomalacia
Root Cause:
Cadmium exposure occurs primarily through inhalation of fumes or dust (e.g., in industrial settings) or ingestion of contaminated food or water. Cadmium accumulates in the kidneys and bones, leading to oxidative stress, cellular damage, and impaired calcium metabolism.
How it's Diagnosed: videos
Diagnosis is made by measuring cadmium levels in blood or urine. Renal function tests (e.g., urinary protein levels) and bone density studies are often conducted to assess long-term damage.
Treatment:
Treatment includes removing the source of cadmium exposure, supportive care for symptoms, and chelation therapy in severe cases. Calcium and vitamin D supplementation may be recommended for bone health.
Medications:
Chelating agents like dimercaprol and EDTA (ethylenediaminetetraacetic acid) may be used in cases of severe poisoning. Chelation is less effective for chronic exposure due to cadmium's strong tissue binding.
Prevalence:
How common the health condition is within a specific population.
Cadmium poisoning is more common in industrial workers (e.g., battery manufacturing, metal plating) and populations exposed to contaminated food or water, particularly in areas with poor environmental regulations.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Occupational exposure (e.g., smelting, welding), smoking (tobacco contains cadmium), consumption of cadmium-contaminated food (e.g., rice, shellfish), and living near industrial sites.
Prognosis:
The expected outcome or course of the condition over time.
Early removal from exposure can improve outcomes, but chronic exposure may result in irreversible kidney damage, bone demineralization, and other complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Long-term complications include chronic kidney disease (CKD), osteoporosis, fractures, respiratory disorders (e.g., emphysema), and an increased risk of cancers (e.g., lung, prostate).
Chromium Toxicity
Specialty: Toxicology
Category: Chronic Toxicity and Long-Term Exposures
Sub-category: Heavy Metal Toxicity
Symptoms:
skin ulcers; rash; respiratory issues (cough, wheezing); abdominal pain; nausea; vomiting; fatigue; headaches; cognitive impairment; kidney damage; liver dysfunction
Root Cause:
Chromium toxicity occurs through inhalation of chromium-containing dust or fumes (commonly in industrial settings), or ingestion of contaminated food or water. Chromium (especially hexavalent chromium) is a potent carcinogen and irritates tissues, leading to cellular and organ damage.
How it's Diagnosed: videos
Diagnosis is based on measuring chromium levels in urine, blood, or sputum. Occupational history and clinical symptoms are key, particularly in those with chronic exposure.
Treatment:
Treatment involves removal from exposure, supportive care for symptoms, and possible chelation therapy for high chromium levels. Bronchodilators may be used for respiratory symptoms.
Medications:
Chelating agents like dimercaprol, EDTA, and penicillamine can be used to help remove chromium from the body in cases of severe poisoning. However, chromium toxicity primarily requires supportive management and removal of the exposure source.
Prevalence:
How common the health condition is within a specific population.
Chromium toxicity is more common in individuals working in industries like metal plating, welding, and leather tanning, as well as those exposed to contaminated water sources.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Occupational exposure (e.g., metal plating, cement production, leather tanning), environmental contamination, living near industrial sites, and consuming water contaminated with hexavalent chromium.
Prognosis:
The expected outcome or course of the condition over time.
The prognosis depends on the severity of exposure and the timeliness of medical intervention. Chronic exposure can lead to irreversible lung damage, kidney failure, and an increased risk of cancer.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Long-term complications include respiratory diseases (e.g., lung cancer, asthma), kidney and liver damage, skin ulcers, and gastrointestinal issues. Chronic exposure may also lead to an increased risk of cancers, particularly lung and gastrointestinal cancers.
Acute Radiation Syndrome (ARS)
Specialty: Toxicology
Category: Chronic Toxicity and Long-Term Exposures
Sub-category: Radiation Exposure
Symptoms:
nausea; vomiting; diarrhea; skin burns; hair loss; weakness; bleeding; infections
Root Cause:
Damage to rapidly dividing cells and tissues due to high-dose ionizing radiation exposure over a short period.
How it's Diagnosed: videos
Medical history of radiation exposure, symptoms onset, blood tests (lymphocyte count), and dosimetry (measuring radiation dose received).
Treatment:
Supportive care (hydration, pain management, and infection control), growth factors to stimulate bone marrow recovery, blood transfusions, antibiotics, and stem cell transplantation in severe cases.
Medications:
Growth factors like filgrastim (granulocyte colony-stimulating factor, G-CSF) to promote white blood cell recovery; anti-nausea medications such as ondansetron (serotonin antagonist); antibiotics or antifungals for infection control; potassium iodide to block thyroid uptake of radioactive iodine.
Prevalence:
How common the health condition is within a specific population.
Rare; typically occurs after nuclear accidents, medical radiation mishaps, or radiation weapon exposure.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Proximity to nuclear explosions or accidents, occupational exposure without proper protective measures, and participation in nuclear weaponry-related activities.
Prognosis:
The expected outcome or course of the condition over time.
Varies by radiation dose; low to moderate doses may allow recovery, while high doses can lead to fatal organ failure within days to weeks.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Secondary infections, hemorrhage, organ failure, and long-term risks of cancer due to DNA damage.
Toxic effects of solvents (e.g., paint thinners, glues)
Specialty: Toxicology
Category: Acute and Chronic Toxicity
Sub-category: Industrial Chemicals and Solvents
Symptoms:
dizziness; headache; confusion; nausea; vomiting; dermatitis; irritation of the respiratory system; fatigue; memory impairment with chronic exposure
Root Cause:
Solvents cause toxicity through inhalation, ingestion, or skin absorption, leading to damage to the central nervous system, respiratory system, and skin. Chronic exposure can result in neurotoxicity.
How it's Diagnosed: videos
Diagnosis is based on exposure history, clinical symptoms, imaging (e.g., chest X-ray or MRI for neurological effects), and laboratory tests to detect solvent metabolites in blood or urine.
Treatment:
Immediate treatment involves removing the person from exposure, providing supportive care, oxygen therapy for respiratory distress, and treating systemic effects. Skin exposure requires thorough washing.
Medications:
Medications depend on symptoms
Prevalence:
How common the health condition is within a specific population.
Common among industrial workers, painters, and individuals using glue for recreational inhalation ("huffing").
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Occupational exposure, recreational inhalant use, inadequate protective measures, and prolonged use in poorly ventilated spaces.
Prognosis:
The expected outcome or course of the condition over time.
Acute exposures often resolve with appropriate care, but chronic exposure may lead to irreversible neurological damage.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Peripheral neuropathy, chronic headaches, liver damage, and kidney damage.
Ricin poisoning (castor bean plant)
Specialty: Toxicology
Category: Biological and Natural Toxins
Sub-category: Plant Toxins
Symptoms:
nausea; vomiting; diarrhea; abdominal pain; severe dehydration; organ failure; difficulty breathing (if inhaled); seizures
Root Cause:
Ricin is a highly toxic protein that inhibits protein synthesis at the cellular level, causing cell death and widespread tissue damage.
How it's Diagnosed: videos
Clinical history of exposure (e.g., ingestion, inhalation, or injection of castor beans); confirmed with laboratory tests for ricin in blood, urine, or environmental samples.
Treatment:
Supportive care (IV fluids, mechanical ventilation for respiratory distress, medications to manage organ failure), decontamination (activated charcoal for ingestion), and symptomatic treatment.
Medications:
No specific antidote exists for ricin. Supportive treatments may include anti-seizure medications (benzodiazepines like lorazepam ), anti-inflammatory drugs, and oxygen therapy.
Prevalence:
How common the health condition is within a specific population.
Rare; typically associated with accidental ingestion or intentional poisoning.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Handling or ingesting castor beans, occupational exposure (e.g., castor oil production).
Prognosis:
The expected outcome or course of the condition over time.
Depends on dose and route of exposure; severe cases without prompt treatment can be fatal. Survival is possible with early supportive care.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Respiratory failure, kidney failure, multi-organ dysfunction, death in severe cases.
Foxglove (digitalis) toxicity
Specialty: Toxicology
Category: Biological and Natural Toxins
Sub-category: Plant Toxins
Symptoms:
nausea; vomiting; diarrhea; abdominal pain; confusion; visual disturbances (e.g., seeing halos around lights); irregular heart rhythms
Root Cause:
Digitalis compounds interfere with sodium-potassium ATPase in cardiac cells, leading to increased intracellular calcium and altered heart function.
How it's Diagnosed: videos
Clinical presentation, history of foxglove exposure or ingestion, and elevated serum digoxin levels.
Treatment:
Activated charcoal (if ingestion is recent), digoxin-specific antibody fragments (Digibind), and management of arrhythmias (e.g., with anti-arrhythmic drugs or temporary pacing).
Medications:
Digibind (digoxin-specific antibody fragments); anti-arrhythmics like lidocaine may be used for ventricular arrhythmias.
Prevalence:
How common the health condition is within a specific population.
Rare in modern contexts; usually due to accidental ingestion or misuse of foxglove extracts.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Accidental ingestion, herbal remedy misuse, or overdose of digoxin-containing medications.
Prognosis:
The expected outcome or course of the condition over time.
Good with early recognition and treatment; severe cases can be life-threatening.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Life-threatening arrhythmias, cardiac arrest, neurological complications (e.g., seizures).
Snake venom poisoning
Specialty: Toxicology
Category: Biological and Natural Toxins
Sub-category: Animal Toxins
Symptoms:
pain at the bite site; swelling; difficulty breathing; nausea; vomiting; dizziness; weakness; blurred vision; bleeding; paralysis
Root Cause:
Envenomation by the venom of a snake, which contains proteins that can damage tissue, blood vessels, and organs.
How it's Diagnosed: videos
Diagnosis is based on clinical signs and symptoms, the type of snake (if known), and laboratory tests like blood clotting studies, complete blood count (CBC), and snake venom detection kits.
Treatment:
Antivenom administration is the primary treatment, along with supportive care such as fluid management, pain relief, and respiratory support.
Medications:
The main treatment is antivenom, which is a specific antibody designed to neutralize venom toxins. Pain relief can be managed with opioids or non-steroidal anti-inflammatory drugs (NSAIDs), depending on the severity of the pain. In severe cases, corticosteroids may be used to reduce inflammation and swelling. Anticoagulants may be used for clotting issues, and antibiotics may be given if secondary infections are a concern.
Prevalence:
How common the health condition is within a specific population.
Worldwide, approximately 5.4 million cases of snakebite occur annually, with about 100,000 deaths.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Proximity to snake habitats, agricultural work, lack of access to medical care, and unawareness of proper snakebite prevention.
Prognosis:
The expected outcome or course of the condition over time.
If treated promptly with antivenom and appropriate medical care, the prognosis is generally good. However, severe envenomations can cause lasting damage or death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Severe complications may include tissue necrosis, renal failure, hemorrhage, paralysis, and death. Long-term effects may include limb amputations, kidney dysfunction, or chronic pain.
Scorpion stings
Specialty: Toxicology
Category: Biological and Natural Toxins
Sub-category: Animal Toxins
Symptoms:
pain at the sting site; swelling; numbness; muscle twitching; difficulty breathing; fever; vomiting; high blood pressure
Root Cause:
Injection of neurotoxins from a scorpion's sting, which affect nerve cells and can cause localized or systemic reactions.
How it's Diagnosed: videos
Diagnosis is clinical, based on the patient's symptoms, history of exposure, and the species of scorpion involved.
Treatment:
Local pain management with analgesics, and antivenom in severe cases. Other treatments may include muscle relaxants, antihistamines, and intravenous fluids.
Medications:
Scorpion antivenom is the primary medication for severe stings, especially in children or vulnerable individuals. Analgesics (e.g., acetaminophen or ibuprofen ) are used for pain relief, while anticonvulsants and sedatives may be used in cases of systemic symptoms. In cases of an allergic reaction, corticosteroids or antihistamines may be prescribed.
Prevalence:
How common the health condition is within a specific population.
Scorpion stings are common in tropical and subtropical regions, with an estimated 1.2 million stings occurring annually worldwide.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Living in areas where scorpions are prevalent, working outdoors at night, or having a weakened immune system.
Prognosis:
The expected outcome or course of the condition over time.
Most cases are mild and self-limited, but severe reactions can occur, especially in young children or the elderly. With prompt treatment, the prognosis is typically favorable.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Serious complications include respiratory distress, seizures, and, rarely, death. Persistent local pain and numbness can also occur.
Spider bites (e.g., black widow, brown recluse)
Specialty: Toxicology
Category: Biological and Natural Toxins
Sub-category: Animal Toxins
Symptoms:
localized pain; muscle cramps; sweating; nausea; vomiting; fever; chills; skin necrosis; tissue damage
Root Cause:
Venom injection from spiders containing neurotoxins or cytotoxins, leading to local and systemic symptoms.
How it's Diagnosed: videos
Diagnosis is based on clinical presentation and history of exposure to venomous spiders. In some cases, laboratory tests may be used to detect systemic effects of envenomation.
Treatment:
Treatment involves pain management, wound care, and, in severe cases, antivenom or muscle relaxants. Surgery may be needed for extensive tissue damage from brown recluse bites.
Medications:
For black widow spider bites, antivenom may be used for severe cases. Pain relief medications such as acetaminophen or NSAIDs are typically prescribed. Muscle relaxants like benzodiazepines may be used for severe muscle cramps, while corticosteroids can reduce inflammation. In cases of skin necrosis, antibiotics or even surgical intervention may be required.
Prevalence:
How common the health condition is within a specific population.
In the U.S., there are approximately 2,500 to 3,000 cases of black widow bites and 1,000 to 2,000 cases of brown recluse bites annually.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Living in areas where venomous spiders are common, being outdoors at night, or disturbing spider habitats.
Prognosis:
The expected outcome or course of the condition over time.
Most spider bites are not fatal and can be managed with appropriate medical care. Severe cases may lead to long-term scarring, particularly with brown recluse bites.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Tissue necrosis, systemic symptoms like hypertension or respiratory distress, and secondary infections can occur, especially in immunocompromised individuals.
Marine envenomations (e.g., jellyfish, stonefish, cone snail)
Specialty: Toxicology
Category: Biological and Natural Toxins
Sub-category: Animal Toxins
Symptoms:
pain or stinging sensation; swelling; nausea; vomiting; difficulty breathing; paralysis; heart arrhythmias; skin lesions
Root Cause:
Envenomation by marine organisms that release toxins into the body, affecting the nervous system, cardiovascular system, or causing local tissue damage.
How it's Diagnosed: videos
Diagnosis is based on the history of exposure to marine creatures, clinical presentation, and identification of the specific venomous species involved.
Treatment:
Treatment includes immediate first aid (e.g., rinsing with vinegar for jellyfish stings, immersion in hot water), pain relief, and administration of specific antivenoms or supportive care. In some cases, defibrillation or respiratory support may be required.
Medications:
Jellyfish stings may be treated with analgesics (NSAIDs or acetaminophen ) for pain. For severe envenomations, antivenom may be administered. Other medications could include corticosteroids to reduce inflammation, and calcium gluconate for specific marine toxins like stonefish venom. Muscle relaxants and antiarrhythmics may be used for severe systemic effects.
Prevalence:
How common the health condition is within a specific population.
Marine envenomations are common in coastal areas, with jellyfish stings alone resulting in millions of cases annually, especially in tropical regions.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Swimming in areas known for venomous marine life, lack of awareness, and seasonal variation in marine toxin release.
Prognosis:
The expected outcome or course of the condition over time.
The prognosis depends on the species involved and the severity of the envenomation. Most cases are mild, but severe reactions can cause long-term complications or be fatal.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Respiratory failure, cardiac arrhythmias, neurological damage, and, in extreme cases, death. Secondary infections or permanent scarring may occur due to skin lesions.
Mycotoxin exposure (e.g., aflatoxins from mold)
Specialty: Toxicology
Category: Biological and Natural Toxins
Sub-category: Bacterial and Fungal Toxins
Symptoms:
nausea; vomiting; abdominal pain; fatigue; jaundice; liver damage; immunosuppression
Root Cause:
Mycotoxins, such as aflatoxins produced by molds (Aspergillus species), can contaminate food and cause toxic effects, especially on the liver.
How it's Diagnosed: videos
Diagnosis involves testing food or body fluids (e.g., urine, blood) for the presence of specific mycotoxins. Liver function tests may show signs of damage.
Treatment:
There is no specific antidote for mycotoxin poisoning. Treatment is supportive and involves addressing liver damage, detoxification, and managing symptoms.
Medications:
"Activated charcoal " (used in the treatment of poisonings, classified as an adsorbent to prevent toxin absorption), "liver protectants" (such as silymarin or N-acetylcysteine), "antioxidants" (to reduce oxidative damage).
Prevalence:
How common the health condition is within a specific population.
Aflatoxins affect millions of people globally, especially in developing countries with poor agricultural practices, with exposure often through contaminated food like peanuts, maize, and grains.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Poor food storage, high humidity, warm temperatures, and poor agricultural practices leading to fungal contamination.
Prognosis:
The expected outcome or course of the condition over time.
Long-term exposure to mycotoxins can lead to chronic liver damage, including cirrhosis and liver cancer, but acute poisoning may resolve with supportive care.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic liver disease, immunosuppression, increased risk of liver cancer, and death in severe cases.
Ciguatera Fish Poisoning
Specialty: Toxicology
Category: Biological and Natural Toxins
Sub-category: Foodborne and Natural Toxins
Symptoms:
nausea; vomiting; diarrhea; abdominal pain; muscle weakness; numbness; tingling in limbs; temperature reversal (cold objects feel hot, and hot objects feel cold); fatigue
Root Cause:
Toxins (ciguatoxins) produced by marine dinoflagellates accumulate in certain fish species, causing symptoms after ingestion.
How it's Diagnosed: videos
Diagnosis is primarily clinical, based on history of fish consumption and characteristic symptoms. Confirmation is difficult, but urine or blood tests may detect ciguatoxins, though they are not routinely available.
Treatment:
Treatment is supportive, including hydration, pain management, and anti-nausea medications. There is no specific antidote for ciguatera poisoning.
Medications:
Symptomatic medications may include antihistamines, antiemetics (e.g., ondansetron ), and analgesics for pain relief (e.g., acetaminophen or ibuprofen ). In severe cases, intravenous fluids may be required. Some case reports suggest using mannitol (a diuretic) for neurological symptoms, though this is controversial.
Prevalence:
How common the health condition is within a specific population.
Ciguatera poisoning is more common in tropical and subtropical regions, especially in the Pacific Islands, Caribbean, and coastal areas of Southeast Asia.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Consumption of large reef fish (e.g., barracuda, grouper, snapper), especially from tropical or subtropical waters.
Prognosis:
The expected outcome or course of the condition over time.
Most people recover fully within weeks to months, but some may experience persistent neurological symptoms (e.g., temperature reversal) for months or years.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Long-term neurological effects, such as persistent numbness, tingling, and temperature sensation reversal. Rare cases may have cardiovascular complications such as arrhythmias.
Scombroid Poisoning
Specialty: Toxicology
Category: Biological and Natural Toxins
Sub-category: Foodborne and Natural Toxins
Symptoms:
flushing; rash; headache; abdominal cramps; diarrhea; nausea; vomiting; burning or metallic taste
Root Cause:
Histamine accumulation in fish (typically tuna, mackerel, or sardines) due to improper storage or handling, leading to an allergic-like reaction.
How it's Diagnosed: videos
Diagnosis is based on clinical symptoms and history of eating improperly stored fish. Laboratory tests for elevated histamine levels in the fish can help confirm the diagnosis.
Treatment:
Antihistamines (e.g., diphenhydramine) for symptom relief, and in severe cases, epinephrine may be required for anaphylaxis-like reactions.
Medications:
Antihistamines (e.g., diphenhydramine , loratadine ) are typically prescribed. In some cases, corticosteroids or epinephrine may be used for severe reactions.
Prevalence:
How common the health condition is within a specific population.
It is more common in warm climates, particularly in tropical and subtropical regions, affecting people who consume improperly stored or handled fish.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Consumption of poorly refrigerated or improperly stored scombroid fish species.
Prognosis:
The expected outcome or course of the condition over time.
Generally good with prompt treatment. Symptoms often resolve within a few hours to a day.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
In severe cases, anaphylaxis may occur, requiring immediate medical attention.
Paralytic Shellfish Poisoning
Specialty: Toxicology
Category: Biological and Natural Toxins
Sub-category: Foodborne and Natural Toxins
Symptoms:
numbness; tingling; dizziness; weakness; paralysis; respiratory distress; difficulty swallowing; nausea; vomiting
Root Cause:
Toxins (saxitoxins) produced by certain marine algae accumulate in shellfish (e.g., clams, mussels, oysters), leading to poisoning after consumption.
How it's Diagnosed: videos
Diagnosis is based on clinical presentation and history of shellfish consumption from affected areas. Laboratory tests can detect saxitoxins in shellfish, blood, or urine.
Treatment:
There is no specific antidote. Treatment is supportive, including respiratory support (e.g., mechanical ventilation) in severe cases. Activated charcoal may be used if ingestion is recent.
Medications:
No specific medications are used, but supportive care involves fluids, respiratory support, and sometimes atropine for bradycardia. Antihistamines and antiemetics may be used for mild cases.
Prevalence:
How common the health condition is within a specific population.
Occurs primarily in coastal regions where shellfish harvesting occurs. Prevalence can vary depending on local algal blooms.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Consumption of shellfish during bloom seasons when high levels of toxins are present.
Prognosis:
The expected outcome or course of the condition over time.
The prognosis depends on the severity of symptoms. Most individuals recover within hours to days if treated promptly.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
In severe cases, respiratory failure, paralysis, or death can occur due to respiratory muscle paralysis.
Amanita Mushroom Poisoning
Specialty: Toxicology
Category: Biological and Natural Toxins
Sub-category: Foodborne and Natural Toxins
Symptoms:
nausea; vomiting; abdominal pain; diarrhea; jaundice; liver failure; renal failure; confusion; seizures
Root Cause:
The ingestion of Amanita mushrooms, especially species like Amanita phalloides (death cap), which contain potent toxins (amatoxins) that damage the liver and kidneys.
How it's Diagnosed: videos
Diagnosis is based on clinical history (ingestion of suspected mushrooms), clinical symptoms, and laboratory tests (e.g., liver function tests, mushroom identification). Detection of amatoxins in urine may confirm diagnosis.
Treatment:
Treatment involves supportive care (e.g., intravenous fluids, liver dialysis), and in severe cases, liver transplantation may be required. Antidotes like silibinin (milk thistle extract) and N-acetylcysteine may help.
Medications:
Antidotes such as silibinin (a liver protectant) and N-acetylcysteine (used for liver support) may be prescribed. In some cases, activated charcoal is used if the mushroom was ingested recently.
Prevalence:
How common the health condition is within a specific population.
Amanita mushroom poisoning is rare but serious, often occurring during the mushroom-picking season, typically in temperate climates.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Mushroom foraging, especially by individuals who may confuse toxic species with edible ones. Lack of mushroom identification expertise.
Prognosis:
The expected outcome or course of the condition over time.
If treated early, the prognosis may be improved. However, poisoning can lead to severe liver and kidney damage or death if not addressed promptly.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Liver failure, renal failure, long-term organ damage, and death in severe cases.
Chemotherapy-related toxicity (e.g., cisplatin, doxorubicin)
Specialty: Toxicology
Category: Adverse Effects of Therapeutics and Medical Agents
Sub-category: Drug-Induced Toxicity
Symptoms:
nausea; vomiting; fatigue; anemia; peripheral neuropathy; hearing loss (ototoxicity); cardiotoxicity; renal dysfunction
Root Cause:
Chemotherapy agents damage both cancerous and healthy cells, leading to systemic toxicity. Cisplatin causes renal and ototoxicity, while doxorubicin is known for cardiotoxicity.
How it's Diagnosed: videos
Clinical symptoms, laboratory tests (renal function, cardiac markers), audiometry (for hearing loss), and imaging studies (e.g., echocardiogram for cardiotoxicity).
Treatment:
Symptomatic management, dose adjustment or discontinuation of the chemotherapy agent, and supportive measures like hydration for renal protection or use of cardioprotective agents.
Medications:
Medications to mitigate toxicity include amifostine (cytoprotective agent), dexrazoxane (cardioprotective for doxorubicin ), antiemetics like ondansetron , and growth factors like filgrastim to manage neutropenia.
Prevalence:
How common the health condition is within a specific population.
Common among patients undergoing chemotherapy; up to 90% may experience some degree of toxicity.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
High cumulative dose, pre-existing kidney or heart conditions, older age, and genetic predisposition.
Prognosis:
The expected outcome or course of the condition over time.
Variable depending on severity; early recognition and management improve outcomes. Some toxicities may be irreversible, such as hearing loss or chronic heart failure.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic kidney disease, heart failure, irreversible neuropathy, or secondary malignancies.
Nonsteroidal anti-inflammatory drug (NSAID) toxicity
Specialty: Toxicology
Category: Adverse Effects of Therapeutics and Medical Agents
Sub-category: Drug-Induced Toxicity
Symptoms:
gastric pain; nausea; vomiting; gastrointestinal bleeding; acute kidney injury; hyperkalemia
Root Cause:
NSAIDs inhibit cyclooxygenase enzymes, reducing prostaglandin synthesis, which compromises gastric mucosal protection, renal perfusion, and platelet aggregation.
How it's Diagnosed: videos
Clinical history, laboratory tests (renal function, electrolytes), stool tests for occult blood, and imaging for gastrointestinal perforations.
Treatment:
Discontinuation of NSAIDs, proton pump inhibitors (e.g., omeprazole) for gastric protection, IV fluids for renal support, and treatment of complications like anemia or bleeding.
Medications:
Proton pump inhibitors (e.g., omeprazole ), misoprostol (for gastric mucosal protection), or activated charcoal (in acute overdose).
Prevalence:
How common the health condition is within a specific population.
Common; NSAID-related adverse effects are seen in up to 25% of chronic users.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Long-term use, high doses, older age, concurrent anticoagulant or corticosteroid use, and pre-existing kidney or gastrointestinal conditions.
Prognosis:
The expected outcome or course of the condition over time.
Good with early management; severe complications like GI perforation or kidney failure can be life-threatening.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Peptic ulcer disease, gastrointestinal perforation, chronic kidney disease, or cardiovascular events.
Radiation therapy-induced toxicity
Specialty: Toxicology
Category: Adverse Effects of Therapeutics and Medical Agents
Sub-category: Iatrogenic Conditions
Symptoms:
skin burns; fatigue; nausea; vomiting; dry mouth; difficulty swallowing; pneumonitis; esophagitis
Root Cause:
The ionizing radiation used in cancer therapy causes damage to normal healthy tissues, leading to acute or chronic inflammation and cellular damage.
How it's Diagnosed: videos
Diagnosis is based on clinical symptoms, timing in relation to radiation therapy, and imaging findings; biopsy or laboratory tests may be used to assess tissue damage.
Treatment:
Management involves corticosteroids, anti-nausea medications, pain relief, and symptomatic management of skin or mucosal irritation. Depending on the affected organ, more specific treatments may be required (e.g., antibiotics for radiation pneumonitis).
Medications:
Corticosteroids (e.g., prednisone , dexamethasone ) are used to reduce inflammation, anti-nausea drugs (e.g., ondansetron ), pain relievers, and sometimes antibiotics or immunosuppressants for more severe reactions.
Prevalence:
How common the health condition is within a specific population.
Radiation-induced toxicity is a common complication, though its severity depends on the type and location of radiation therapy.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
High radiation doses, field size, proximity of radiation to critical organs, underlying health conditions (e.g., diabetes, heart disease), and concurrent chemotherapy.
Prognosis:
The expected outcome or course of the condition over time.
Most toxicity symptoms resolve after treatment; however, long-term or permanent tissue damage can occur, especially with high doses.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic fatigue, fibrosis, secondary cancers, esophageal stenosis, and pulmonary issues.
Contrast-induced nephropathy (from imaging studies)
Specialty: Toxicology
Category: Adverse Effects of Therapeutics and Medical Agents
Sub-category: Iatrogenic Conditions
Symptoms:
acute kidney dysfunction; decreased urine output; swelling; nausea; vomiting; fatigue
Root Cause:
Contrast agents used in imaging studies can cause kidney damage, typically through direct toxicity to the renal tubular cells or through causing vasoconstriction, reducing blood flow to the kidneys.
How it's Diagnosed: videos
Diagnosis involves assessing kidney function through serum creatinine levels, urine output, and the timing of symptoms in relation to contrast exposure. Imaging may also show signs of kidney damage.
Treatment:
The mainstay of treatment is supportive care, which includes hydration, monitoring kidney function, and possibly using diuretics in some cases. Dialysis may be required in severe cases.
Medications:
N-acetylcysteine (a potential preventive measure), bicarbonate infusions (to alkalinize urine and prevent nephropathy), and diuretics (e.g., furosemide ) may be used if necessary to manage kidney function.
Prevalence:
How common the health condition is within a specific population.
Contrast-induced nephropathy occurs in approximately 2-5% of patients exposed to contrast media, though this varies with the population studied and the type of contrast used.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Pre-existing renal disease, dehydration, diabetes, older age, use of high-osmolar contrast agents, and concurrent use of nephrotoxic drugs.
Prognosis:
The expected outcome or course of the condition over time.
Most patients recover with appropriate management, but some may develop chronic kidney disease or require dialysis.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic kidney disease, electrolyte imbalances, and in rare cases, kidney failure.
Fluoride Toxicity
Specialty: Toxicology
Category: Toxic Effects of Environmental Pollutants
Sub-category: Water Contaminants
Symptoms:
stomach pain; vomiting; diarrhea; weakness; bone pain; dental fluorosis; skeletal fluorosis
Root Cause:
Excessive exposure to fluoride, often from contaminated water or overuse of fluoride-containing products, leading to toxicity.
How it's Diagnosed: videos
Diagnosis is based on symptoms, medical history, and elevated levels of fluoride in blood or urine.
Treatment:
Treatment includes removing the source of fluoride exposure, intravenous calcium or magnesium to bind excess fluoride, and supportive care.
Medications:
No specific antidote exists, but medications such as calcium gluconate (a calcium salt used to treat hypocalcemia), activated charcoal (for oral poisoning), and IV fluids to manage dehydration and electrolyte imbalance may be used. These medications are categorized as antidotes, electrolytes , and fluids.
Prevalence:
How common the health condition is within a specific population.
Fluoride toxicity is rare in areas with controlled levels of fluoride in water, but it can be more common in areas with high natural fluoride levels or improper use of fluoride-containing products.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Excessive consumption of fluoride, especially in young children, long-term exposure to high fluoride levels in drinking water or industrial areas, and consumption of improperly prepared fluoride toothpaste.
Prognosis:
The expected outcome or course of the condition over time.
Acute toxicity is usually reversible with prompt treatment, but chronic exposure can lead to long-term skeletal and dental damage.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Long-term fluoride exposure can lead to bone deformities (skeletal fluorosis), dental fluorosis, and potential kidney damage in severe cases.
Nitrate/Nitrite Poisoning (Blue Baby Syndrome)
Specialty: Toxicology
Category: Toxic Effects of Environmental Pollutants
Sub-category: Water Contaminants
Symptoms:
cyanosis; shortness of breath; fatigue; vomiting; diarrhea; irritability
Root Cause:
Nitrates in water are reduced to nitrites in the body, which interfere with the ability of hemoglobin to carry oxygen, leading to hypoxia.
How it's Diagnosed: videos
Diagnosis is confirmed by measuring blood methemoglobin levels and detecting elevated nitrate/nitrite concentrations in water or food sources.
Treatment:
Treatment involves administering methylene blue (a medication that converts methemoglobin back to hemoglobin), oxygen therapy, and removal from the contaminated environment.
Medications:
Methylene blue (a medication used to treat methemoglobinemia) is the primary treatment for nitrate/nitrite poisoning. It is classified as an antidote for methemoglobinemia.
Prevalence:
How common the health condition is within a specific population.
Blue baby syndrome is primarily found in infants under six months old, particularly in rural areas where water sources are contaminated with high levels of nitrates.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Use of well water contaminated with nitrates, young infants consuming formula mixed with nitrate-contaminated water, and agricultural runoff in farming areas.
Prognosis:
The expected outcome or course of the condition over time.
If treated early with methylene blue, the prognosis is usually good. However, severe cases can lead to neurological damage if not treated in time.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Without prompt treatment, cyanosis and severe hypoxia can lead to death. Chronic exposure to high levels of nitrates can also cause long-term developmental issues in infants.
Pesticide Residue Exposure
Specialty: Toxicology
Category: Toxic Effects of Environmental Pollutants
Sub-category: Soil and Agricultural Toxins
Symptoms:
nausea; vomiting; dizziness; headache; fatigue; skin irritation; respiratory issues
Root Cause:
Chronic or acute exposure to pesticide residues on food, in water, or in the environment leads to the accumulation of toxic substances in the body, potentially causing cellular and systemic damage.
How it's Diagnosed: videos
Diagnosed through patient history, physical examination, and laboratory tests, such as blood and urine tests to detect pesticide metabolites or biomarkers.
Treatment:
Immediate treatment involves removing the source of exposure, administering activated charcoal or gastric lavage (in acute cases), and providing supportive care for symptoms. Long-term management includes chelation therapy in severe cases and reducing exposure through dietary and environmental modifications.
Medications:
No specific antidotes for most pesticide exposures. Symptomatic treatments include atropine (anticholinergic for organophosphate poisoning), pralidoxime (cholinesterase reactivator for certain organophosphate toxicities), and anti-nausea medications such as ondansetron .
Prevalence:
How common the health condition is within a specific population.
Common in agricultural regions; widespread globally due to the use of pesticides in farming. The World Health Organization estimates millions of cases of pesticide poisoning annually, with thousands of deaths.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Occupational exposure (farmers, agricultural workers), consuming non-organic produce, proximity to areas with heavy pesticide use, inadequate protective measures during pesticide application.
Prognosis:
The expected outcome or course of the condition over time.
Prognosis depends on the level and duration of exposure. Acute poisoning has a good prognosis with timely treatment, but chronic exposure may result in long-term health effects, including neurological and endocrine disorders.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic toxicity can lead to endocrine disruption, neurodegenerative diseases, cancer, reproductive issues, and developmental delays in children.
Herbicide Toxicity (e.g., Glyphosate)
Specialty: Toxicology
Category: Toxic Effects of Environmental Pollutants
Sub-category: Soil and Agricultural Toxins
Symptoms:
skin irritation; burning sensation in the throat; difficulty breathing; nausea; vomiting; abdominal pain; diarrhea
Root Cause:
Exposure to herbicides like glyphosate causes cellular damage through oxidative stress and disruption of enzyme systems critical for normal physiological function. Ingestion of concentrated formulations may lead to corrosive injury.
How it's Diagnosed: videos
Diagnosed through patient history, clinical presentation, and laboratory tests to detect glyphosate or its metabolites in blood or urine. Imaging studies may assess organ damage in severe cases.
Treatment:
Supportive care includes decontamination (removal of contaminated clothing, washing skin), gastric lavage for ingestion, intravenous fluids, and monitoring of respiratory and renal function. Activated charcoal may be administered to reduce absorption.
Medications:
No specific antidote is available . Symptomatic treatments include antiemetics (e.g., ondansetron ), proton pump inhibitors (e.g., omeprazole ) to reduce gastric irritation, and analgesics (e.g., acetaminophen ) for pain relief. Dialysis may be required for renal failure.
Prevalence:
How common the health condition is within a specific population.
Herbicide exposure is common in agricultural communities and areas where herbicides are heavily used. Glyphosate is one of the most widely used herbicides globally. Accidental or occupational exposure affects thousands annually.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Occupational exposure, improper handling or storage of herbicides, lack of protective equipment during application, accidental ingestion, and contamination of drinking water or food.
Prognosis:
The expected outcome or course of the condition over time.
Mild exposure typically resolves with supportive care. Severe exposure can lead to life-threatening complications but has a favorable prognosis with timely medical intervention.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Acute toxicity may cause corrosive injuries to the gastrointestinal tract, respiratory failure, renal impairment, and, in severe cases, cardiovascular collapse. Chronic exposure is associated with an increased risk of cancer, endocrine disruption, and developmental issues.
Uremia (toxins from kidney failure)
Specialty: Toxicology
Category: Endogenous Toxins
Sub-category: Metabolic Disorders
Symptoms:
nausea; vomiting; fatigue; loss of appetite; mental confusion; seizures; muscle cramps; itching; breath with a urine-like odor
Root Cause:
Accumulation of uremic toxins and waste products in the bloodstream due to impaired kidney function, leading to systemic toxicity.
How it's Diagnosed: videos
Blood tests showing elevated blood urea nitrogen (BUN) and creatinine levels; electrolyte imbalances; clinical symptoms; sometimes confirmed with imaging or biopsy of kidneys.
Treatment:
Immediate treatment often involves dialysis (hemodialysis or peritoneal dialysis) to remove toxins, along with addressing the underlying cause (e.g., managing kidney disease or acute kidney injury).
Medications:
Medications to manage symptoms and complications include antihypertensive drugs (e.g., ACE inhibitors like lisinopril or ARBs like losartan ), phosphate binders (e.g., sevelamer ), erythropoiesis-stimulating agents (e.g., epoetin alfa) to manage anemia, and diuretics (e.g., furosemide ) to reduce fluid overload.
Prevalence:
How common the health condition is within a specific population.
Common among patients with chronic kidney disease (CKD), especially in end-stage renal disease (ESRD). Affects approximately 15% of the global population with CKD.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Chronic kidney disease, diabetes, hypertension, recurrent urinary tract infections, genetic predisposition, nephrotoxic medications.
Prognosis:
The expected outcome or course of the condition over time.
Treatable with dialysis or kidney transplant; prognosis depends on the underlying cause and overall health of the patient. Without treatment, it can be fatal.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Heart disease, fluid overload, pericarditis, electrolyte imbalances (e.g., hyperkalemia), neuropathy, bone disease.
Hyperammonemia (e.g., from liver failure)
Specialty: Toxicology
Category: Endogenous Toxins
Sub-category: Hepatic Disorders
Symptoms:
confusion; lethargy; vomiting; irritability; tremors; seizures; coma
Root Cause:
Excess ammonia in the bloodstream due to impaired liver function or inherited metabolic disorders, leading to neurotoxicity.
How it's Diagnosed: videos
Blood tests showing elevated ammonia levels; clinical symptoms; imaging (e.g., CT or MRI) to rule out other causes of neurological dysfunction; genetic testing for inherited disorders.
Treatment:
Lactulose (a non-absorbable sugar) to trap ammonia in the gut, rifaximin to reduce ammonia-producing bacteria, supportive care, and addressing the underlying cause such as liver transplantation in severe cases.
Medications:
Lactulose (osmotic laxative), rifaximin (intestinal antibiotic), sodium benzoate , and sodium phenylbutyrate (ammonia-scavenging agents).
Prevalence:
How common the health condition is within a specific population.
Common in individuals with cirrhosis or acute liver failure; also occurs in certain inherited urea cycle disorders.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Liver cirrhosis, acute liver failure, high-protein diet in susceptible individuals, inherited metabolic disorders.
Prognosis:
The expected outcome or course of the condition over time.
Treatable if addressed early; severe cases can lead to permanent neurological damage or death if untreated.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Hepatic encephalopathy, cerebral edema, coma, death.
Porphyria-related toxicity
Specialty: Toxicology
Category: Endogenous Toxins
Sub-category: Hematologic Disorders
Symptoms:
abdominal pain; nausea; vomiting; constipation; dark urine; seizures; muscle weakness; anxiety; hallucinations
Root Cause:
Accumulation of porphyrins or their precursors due to a defect in the heme biosynthesis pathway, leading to neurotoxicity and other systemic effects.
How it's Diagnosed: videos
Urine and blood tests for porphyrins and precursors (e.g., aminolevulinic acid, porphobilinogen); genetic testing to identify specific mutations.
Treatment:
Glucose infusions or hemin administration to suppress heme biosynthesis, along with supportive care to manage symptoms. Avoidance of triggering factors such as certain medications or fasting.
Medications:
Hemin (synthetic heme, used to downregulate porphyrin production), glucose (for metabolic support).
Prevalence:
How common the health condition is within a specific population.
Rare, with an estimated prevalence of 1 in 25,000 to 1 in 50,000 for acute porphyrias.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Family history, use of triggering medications (e.g., barbiturates, sulfonamides), alcohol consumption, hormonal changes (e.g., during menstruation).
Prognosis:
The expected outcome or course of the condition over time.
With early diagnosis and management, symptoms are reversible, but severe attacks can lead to long-term complications or death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic pain, paralysis, kidney failure, liver damage, severe neurological deficits.
Suicide attempts via pharmaceutical or chemical agents
Specialty: Toxicology
Category: Deliberate and Accidental Poisoning
Sub-category: Intentional Overdoses
Symptoms:
altered mental status; respiratory depression; seizures; nausea; vomiting; abdominal pain; cardiac arrhythmias; coma
Root Cause:
Ingestion of toxic doses of medications (e.g., sedatives, opioids, antidepressants) or chemicals (e.g., household cleaners, industrial substances) causes systemic toxicity and organ dysfunction.
How it's Diagnosed: videos
Clinical history (when available), physical examination, toxicology screens (blood and urine), serum drug levels, and imaging studies (if structural damage is suspected).
Treatment:
Stabilization (airway, breathing, circulation), decontamination (e.g., activated charcoal if appropriate), specific antidotes (e.g., naloxone for opioids), symptomatic management (e.g., anti-seizure medications), and supportive care (e.g., IV fluids, mechanical ventilation).
Medications:
Antidotes such as naloxone (opioid antagonist), flumazenil (benzodiazepine antagonist), and N-acetylcysteine (for acetaminophen overdose); sedatives like benzodiazepines (anticonvulsants) for seizures; and IV fluids for dehydration and hypotension.
Prevalence:
How common the health condition is within a specific population.
Suicide attempts via pharmaceutical or chemical agents account for approximately 10-20% of emergency toxicology cases worldwide, with variations depending on region and accessibility to medications or chemicals.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
History of mental health disorders (e.g., depression, anxiety), access to toxic substances, substance abuse, prior suicide attempts, and social stressors.
Prognosis:
The expected outcome or course of the condition over time.
Prognosis depends on the type and amount of substance ingested, time to treatment, and overall health of the individual. With timely intervention, most cases are survivable. Delayed or inadequate treatment may lead to significant morbidity or mortality.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Organ failure (e.g., liver or kidney damage), aspiration pneumonia, prolonged hospital stays, chronic neurological deficits, and death.
Pediatric ingestions (e.g., iron supplements, cleaning agents)
Specialty: Toxicology
Category: Deliberate and Accidental Poisoning
Sub-category: Accidental Poisoning
Symptoms:
vomiting; abdominal pain; diarrhea; lethargy; seizures; respiratory distress; shock
Root Cause:
Accidental ingestion of toxic substances like medications, cleaning agents, or chemicals due to lack of proper storage or childproofing.
How it's Diagnosed: videos
Based on clinical history, symptoms, and laboratory tests, including blood levels of suspected toxins (e.g., serum iron levels, blood gas analysis).
Treatment:
Decontamination (e.g., activated charcoal), supportive care, specific antidotes if applicable (e.g., deferoxamine for iron toxicity).
Medications:
Antidotes such as deferoxamine (iron chelator), IV fluids for hydration, and antiemetics for symptom control. Deferoxamine is classified as an iron-chelating agent.
Prevalence:
How common the health condition is within a specific population.
A common cause of pediatric emergency visits; exact prevalence depends on local safety measures and poisoning prevention efforts.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Lack of childproof containers, improper storage of medications or chemicals, inadequate supervision, high accessibility of toxic substances.
Prognosis:
The expected outcome or course of the condition over time.
Good with prompt intervention, though severe cases (e.g., iron toxicity) can lead to long-term organ damage or death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Organ failure (e.g., liver failure), metabolic acidosis, gastrointestinal damage, seizures, death.
Food contamination-related poisoning
Specialty: Toxicology
Category: Environmental and Ingestional Poisoning
Sub-category: Foodborne Poisoning
Symptoms:
nausea; vomiting; diarrhea; abdominal cramps; fever; dehydration
Root Cause:
Ingestion of food contaminated by bacteria (e.g., Salmonella, E. coli), viruses (e.g., norovirus), toxins (e.g., aflatoxins), or chemicals (e.g., pesticides).
How it's Diagnosed: videos
Clinical history of food consumption, stool tests for pathogens, and testing for toxins or chemicals in food samples.
Treatment:
Supportive care (e.g., hydration, electrolyte replacement), antibiotics if bacterial infection is identified, or antitoxins for specific poisonings.
Medications:
Antibiotics (e.g., ciprofloxacin for bacterial infections like Salmonella), antiemetics (e.g., ondansetron ), and oral rehydration solutions. Ciprofloxacin is a fluoroquinolone antibiotic.
Prevalence:
How common the health condition is within a specific population.
Affects millions annually worldwide; particularly common in areas with inadequate food safety measures.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Poor food hygiene, contaminated water, improper food storage or preparation, consumption of raw or undercooked food.
Prognosis:
The expected outcome or course of the condition over time.
Generally good with treatment; most cases resolve within days, but severe cases can lead to hospitalization or death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Severe dehydration, hemolytic uremic syndrome (HUS) from E. coli, chronic gastrointestinal issues, or systemic infections.
Mustard gas exposure
Specialty: Toxicology
Category: Miscellaneous Toxicological Conditions
Sub-category: Chemical Terrorism and Warfare Agents
Symptoms:
skin irritation and blistering; eye irritation and corneal damage; respiratory tract damage; nausea; vomiting; bone marrow suppression
Root Cause:
Mustard gas alkylates DNA, causing cellular damage, especially in rapidly dividing tissues such as the skin, mucosa, and bone marrow.
How it's Diagnosed: videos
Clinical diagnosis based on signs and symptoms of exposure; laboratory testing of air, soil, or biological samples may confirm presence of the agent.
Treatment:
Decontamination of skin and eyes, supportive care, administration of antibiotics for secondary infections, and management of bone marrow suppression with growth factors or transfusions.
Medications:
Antibiotics (varied classes) - Used to treat secondary bacterial infections of skin or lungs. Granulocyte colony-stimulating factor (G-CSF) - Stimulates bone marrow recovery in cases of suppression. Analgesics (non-opioid or opioid) - Provide pain relief from skin or respiratory damage.
Prevalence:
How common the health condition is within a specific population.
Rare, limited to chemical warfare or accidental exposures in research or storage facilities.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Lack of protective equipment, proximity to affected areas, inadequate decontamination procedures.
Prognosis:
The expected outcome or course of the condition over time.
Prognosis depends on exposure level and supportive care; long-term complications may include chronic respiratory disease, scarring, or cancer.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Infections, respiratory failure, chronic obstructive pulmonary disease (COPD), scarring, increased cancer risk.
Ricin poisoning
Specialty: Toxicology
Category: Miscellaneous Toxicological Conditions
Sub-category: Bioterrorism Agents
Symptoms:
severe abdominal pain (if ingested); vomiting; diarrhea; difficulty breathing (if inhaled); fever; organ failure
Root Cause:
Ricin inhibits protein synthesis by inactivating ribosomes, leading to cell death, particularly in rapidly dividing or highly active tissues.
How it's Diagnosed: videos
Clinical suspicion based on exposure history and symptoms; laboratory tests can detect ricin in blood, urine, or tissue samples.
Treatment:
Supportive care, including intravenous fluids, ventilation support, and treatment for organ failure; there is no specific antidote for ricin.
Medications:
Electrolyte solutions (e.g., normal saline, Ringer’s lactate) - Treat dehydration caused by severe vomiting and diarrhea. Activated charcoal (adsorbent) - May reduce toxin absorption in cases of early ingestion. Antipyretics (e.g., acetaminophen ) - Manage fever.
Prevalence:
How common the health condition is within a specific population.
Extremely rare, typically associated with intentional poisoning or bioterrorism events.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Handling or exposure to ricin-producing castor beans or involvement in bioterrorism-related events.
Prognosis:
The expected outcome or course of the condition over time.
Poor prognosis with high-dose exposure; survival depends on prompt supportive care and the amount of toxin ingested or inhaled.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Multi-organ failure, permanent organ damage, death.
Heavy metal contamination in traditional remedies
Specialty: Toxicology
Category: Miscellaneous Toxicological Conditions
Sub-category: Herbal and Alternative Medicine Toxicity
Symptoms:
abdominal pain; nausea; vomiting; diarrhea; headache; fatigue; cognitive impairment; kidney dysfunction; anemia; peripheral neuropathy
Root Cause:
Presence of toxic heavy metals (e.g., lead, mercury, arsenic, cadmium) in traditional or alternative remedies due to contamination or intentional adulteration during manufacturing.
How it's Diagnosed: videos
Blood and urine tests to detect heavy metal levels; clinical history of remedy use; imaging or organ function tests for damage assessment.
Treatment:
Immediate discontinuation of the remedy; chelation therapy for heavy metal removal; supportive care for symptoms and organ damage management.
Medications:
Chelating agents such as dimercaprol (a chelating agent for arsenic , mercury, and lead poisoning), succimer (an oral chelator for lead poisoning), and calcium disodium EDTA (used for lead chelation therapy).
Prevalence:
How common the health condition is within a specific population.
Prevalence varies geographically but is significant in regions with widespread use of unregulated traditional remedies.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Use of imported or locally made traditional remedies, lack of regulatory oversight, cultural reliance on alternative medicine, and socioeconomic factors limiting access to conventional healthcare.
Prognosis:
The expected outcome or course of the condition over time.
Prognosis depends on the level and duration of exposure; early intervention improves outcomes, while delayed treatment may lead to irreversible organ damage or chronic health issues.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic kidney disease, neurotoxicity, developmental delays in children, anemia, cardiovascular issues, and increased cancer risk (e.g., arsenic-related carcinogenesis).
Toxic effects of unregulated supplements
Specialty: Toxicology
Category: Miscellaneous Toxicological Conditions
Sub-category: Dietary Supplement and Nutraceutical Toxicity
Symptoms:
nausea; vomiting; liver dysfunction; kidney damage; cardiac arrhythmias; neurological symptoms; metabolic imbalances
Root Cause:
Adverse reactions to unregulated dietary supplements due to contamination, overdoses of active ingredients, or interactions with other medications.
How it's Diagnosed: videos
Comprehensive clinical history, including supplement usage; blood tests for liver and kidney function; toxicology screening for contaminants or active substances.
Treatment:
Immediate cessation of the supplement; supportive care for organ damage; treatment of specific toxicities (e.g., electrolyte management for metabolic imbalances).
Medications:
Treatment depends on the toxicity but may include N-acetylcysteine for liver injury (e.g., acetaminophen-like toxicity), activated charcoal for acute ingestions, or electrolyte replacement therapies.
Prevalence:
How common the health condition is within a specific population.
Growing prevalence due to the global increase in dietary supplement use, with up to 25% of users experiencing some adverse effects.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Use of supplements from unregulated sources, lack of proper dosing information, concurrent use of multiple supplements, pre-existing medical conditions, and inadequate consumer education.
Prognosis:
The expected outcome or course of the condition over time.
Most cases are reversible with early intervention; severe or prolonged exposure may lead to lasting organ damage or increased mortality.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Liver failure, acute kidney injury, cardiotoxicity, metabolic disturbances, allergic reactions, and interaction-induced adverse effects with prescription medications.
Withdrawal syndromes
Specialty: Toxicology
Category: Miscellaneous Toxicological Conditions
Sub-category: Substance Use and Abuse
Symptoms:
anxiety; restlessness; insomnia; nausea; vomiting; sweating; seizures; hallucinations; cravings; muscle pain; tremors
Root Cause:
Withdrawal occurs due to abrupt cessation or reduction in the use of a substance, disrupting the brain's adaptive changes to the drug.
How it's Diagnosed: videos
Clinical evaluation of history, substance use patterns, and physical/psychological symptoms; sometimes aided by withdrawal severity scales.
Treatment:
Gradual tapering of the substance, medications to manage symptoms, supportive care, and behavioral therapy.
Medications:
Alcohol withdrawal - Benzodiazepines (e.g., diazepam , lorazepam ) to prevent seizures and delirium tremens. Opioid withdrawal - Methadone , buprenorphine , or clonidine to manage symptoms and cravings. Nicotine withdrawal - Nicotine replacement therapy (patches, gum), varenicline , or bupropion .
Prevalence:
How common the health condition is within a specific population.
Withdrawal syndromes are common among individuals with substance dependence, with prevalence varying based on substance use patterns.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Prolonged or heavy substance use, abrupt cessation, lack of medical supervision during detoxification.
Prognosis:
The expected outcome or course of the condition over time.
Prognosis depends on the substance, duration of use, and treatment adherence; most symptoms resolve with treatment, though cravings and relapse risk may persist.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Severe complications include seizures, delirium tremens (in alcohol withdrawal), dehydration, cardiac arrhythmias, and suicide risk.
Campylobacter Infections
Specialty: Infectious Diseases
Category: Bacterial Infections
Symptoms:
diarrhea; abdominal pain; fever; nausea; vomiting
Root Cause:
Caused by Campylobacter jejuni or Campylobacter coli, often through contaminated food or water, leading to gastrointestinal inflammation.
How it's Diagnosed: videos
Stool cultures, molecular assays, and antigen tests.
Treatment:
Supportive care for mild cases; antibiotics for severe cases or immunocompromised patients.
Medications:
Azithromycin (macrolide antibiotic) or ciprofloxacin (fluoroquinolone antibiotic).
Prevalence:
How common the health condition is within a specific population.
One of the most common causes of bacterial diarrhea worldwide, with an estimated 96 million cases annually.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Consumption of undercooked poultry, unpasteurized milk, contaminated water, and international travel.
Prognosis:
The expected outcome or course of the condition over time.
Usually self-limiting within a week; antibiotics hasten recovery in severe cases.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Guillain-Barré syndrome, reactive arthritis, and bloodstream infections.
CBRNE - Staphylococcal Enterotoxin B
Specialty: Infectious Diseases
Category: Bacterial Infections
Symptoms:
fever; chills; headache; nausea; vomiting; diarrhea; shortness of breath; potential septic shock
Root Cause:
Caused by exposure to Staphylococcus aureus enterotoxins, which act as superantigens triggering an exaggerated immune response.
How it's Diagnosed: videos
Clinical evaluation based on symptoms and potential exposure history. Laboratory confirmation by identifying enterotoxins in biological samples.
Treatment:
Supportive care (fluids, oxygen therapy). Antibiotics if secondary bacterial infection is suspected.
Medications:
Beta-lactam antibiotics such as cefazolin for secondary infections. Antipyretics like acetaminophen to reduce fever.
Prevalence:
How common the health condition is within a specific population.
Rare; typically associated with bioterrorism events or foodborne outbreaks.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Occupational exposure, bioterrorism incidents, consumption of contaminated food.
Prognosis:
The expected outcome or course of the condition over time.
Good with prompt supportive care; severe cases can result in complications or death if untreated.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Dehydration, respiratory failure, toxic shock syndrome.
Escherichia coli (E coli) Infections
Specialty: Infectious Diseases
Category: Bacterial Infections
Symptoms:
abdominal cramps; diarrhea (can be watery or bloody); nausea; vomiting; fever; fatigue
Root Cause:
Caused by specific strains of E. coli bacteria that produce toxins, leading to gastrointestinal or systemic infections.
How it's Diagnosed: videos
Stool culture, polymerase chain reaction (PCR) testing, and blood tests in severe cases to detect complications like hemolytic uremic syndrome (HUS).
Treatment:
Supportive care with hydration; antibiotics are used selectively, depending on the strain (e.g., avoid in Shiga toxin-producing E. coli). Severe cases may require hospitalization.
Medications:
Antibiotics such as ciprofloxacin (a fluoroquinolone) or TMP-SMX (a combination of trimethoprim and sulfamethoxazole ) for specific strains. Rehydration therapy with oral or IV solutions is critical.
Prevalence:
How common the health condition is within a specific population.
Common cause of foodborne illness worldwide, affecting millions annually.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Consumption of undercooked meat, unpasteurized milk, contaminated water, or poor hand hygiene.
Prognosis:
The expected outcome or course of the condition over time.
Generally resolves within a week for most cases. Complications like HUS can occur in 5–10% of Shiga toxin-producing E. coli infections, requiring intensive care.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Hemolytic uremic syndrome (HUS), kidney failure, dehydration, and sepsis in severe cases.
Helicobacter Pylori Infection
Specialty: Infectious Diseases
Category: Gastrointestinal Tract and Intra-abdominal Infections
Symptoms:
abdominal pain; nausea; vomiting; bloating; loss of appetite; unintentional weight loss; dark or tarry stools (indicating bleeding)
Root Cause:
Chronic infection caused by Helicobacter pylori bacteria, leading to inflammation of the stomach lining and increased risk of peptic ulcers and gastric cancer.
How it's Diagnosed: videos
Urea breath test, stool antigen test, blood test for antibodies, endoscopy with biopsy.
Treatment:
Combination of antibiotics to eradicate the bacteria and proton pump inhibitors (PPIs) to reduce stomach acid.
Medications:
Antibiotics (e.g., amoxicillin , clarithromycin , metronidazole ) to kill the bacteria. Proton pump inhibitors (PPIs, e.g., omeprazole , lansoprazole ) to reduce stomach acid and promote healing. Bismuth subsalicylate (part of quadruple therapy) to protect the stomach lining.
Prevalence:
How common the health condition is within a specific population.
Affects approximately 50% of the global population; more common in developing countries due to poor sanitation.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Poor sanitation, contaminated food and water, close contact with an infected individual, family history of H. pylori infection.
Prognosis:
The expected outcome or course of the condition over time.
Eradication is successful in most cases with appropriate therapy; untreated infections can lead to complications like ulcers or gastric cancer.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Peptic ulcers, gastric cancer, chronic gastritis, iron-deficiency anemia.
Leptospirosis
Specialty: Infectious Diseases
Category: Bacterial Infections
Symptoms:
high fever; muscle pain; headache; vomiting; jaundice; red eyes; skin rash; abdominal pain
Root Cause:
Caused by infection with Leptospira species, transmitted through water contaminated by animal urine, often affecting the liver, kidneys, and lungs.
How it's Diagnosed: videos
Serology (e.g., microscopic agglutination test), polymerase chain reaction (PCR), or culture from blood, urine, or cerebrospinal fluid.
Treatment:
Antibiotics to clear the infection, supportive care for organ involvement, and management of complications such as kidney failure.
Medications:
Doxycycline or penicillin (for mild cases); intravenous ceftriaxone or penicillin G for severe cases.
Prevalence:
How common the health condition is within a specific population.
Common in tropical and subtropical regions, particularly after heavy rainfall or flooding.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Exposure to contaminated water, working with animals, poor sanitation, recreational water activities.
Prognosis:
The expected outcome or course of the condition over time.
Good with early treatment; severe cases (Weil's disease) have a higher risk of mortality.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Kidney damage, meningitis, liver failure, respiratory distress, and hemorrhage.
Meningococcemia
Specialty: Infectious Diseases
Category: Bacterial Infections
Sub-category: Systemic Infections
Symptoms:
fever; rash; cold extremities; rapid breathing; confusion; nausea; vomiting
Root Cause:
Caused by Neisseria meningitidis entering the bloodstream, leading to widespread vascular inflammation and potential sepsis.
How it's Diagnosed: videos
Blood cultures, CSF cultures, Gram stain, or PCR for Neisseria meningitidis DNA.
Treatment:
Immediate antibiotic therapy and supportive care, including fluid resuscitation and management of shock.
Medications:
Ceftriaxone or cefotaxime (cephalosporin-class antibiotics); penicillin G may also be used. Prophylaxis with rifampin (rifamycin-class antibiotic) or ciprofloxacin (fluoroquinolone-class antibiotic) for close contacts.
Prevalence:
How common the health condition is within a specific population.
Sporadic and epidemic cases worldwide; incidence varies widely depending on region and vaccination rates.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Crowded living conditions, immune deficiencies, close contact with infected individuals.
Prognosis:
The expected outcome or course of the condition over time.
Life-threatening without treatment; mortality can be reduced with prompt therapy, but survivors may face long-term complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Septic shock, disseminated intravascular coagulation (DIC), limb loss due to necrosis, neurological damage.
Relapsing Fever
Specialty: Infectious Diseases
Category: Bacterial Infections
Symptoms:
recurring episodes of high fever; chills; headaches; muscle and joint pain; nausea; vomiting; rash
Root Cause:
Caused by infection with Borrelia bacteria transmitted by lice (Louse-Borne Relapsing Fever) or soft-bodied ticks (Tick-Borne Relapsing Fever).
How it's Diagnosed: videos
Blood smear microscopy during febrile episodes, polymerase chain reaction (PCR) testing, or serological tests for Borrelia.
Treatment:
Antibiotics such as doxycycline or erythromycin; supportive care for symptoms like dehydration or electrolyte imbalance.
Medications:
Doxycycline (a tetracycline antibiotic), erythromycin (a macrolide antibiotic), or penicillin G (a beta-lactam antibiotic for severe cases).
Prevalence:
How common the health condition is within a specific population.
Rare in developed countries; more common in resource-limited settings, especially in Africa.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Exposure to tick- or louse-infested areas, living in crowded or unsanitary conditions, and travel to endemic regions.
Prognosis:
The expected outcome or course of the condition over time.
Good with timely treatment; symptoms resolve after antibiotic therapy, though Jarisch-Herxheimer reaction may occur shortly after treatment begins.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Jarisch-Herxheimer reaction, myocarditis, meningitis, multiorgan failure, or death if left untreated.
Rocky Mountain Spotted Fever (RMSF)
Specialty: Infectious Diseases
Category: Bacterial Infections
Sub-category: Rickettsial Diseases
Symptoms:
fever; headache; rash (starting on wrists and ankles); muscle aches; nausea; vomiting; confusion
Root Cause:
Caused by infection with Rickettsia rickettsii, transmitted by tick bites.
How it's Diagnosed: videos
Clinical presentation, serological testing, and PCR.
Treatment:
Immediate administration of doxycycline; treatment is started empirically based on suspicion.
Medications:
Doxycycline (tetracycline antibiotic); chloramphenicol (alternative for pregnant women in certain cases).
Prevalence:
How common the health condition is within a specific population.
Endemic in the Americas, particularly in the southeastern United States.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Exposure to tick-infested areas, lack of protective clothing during outdoor activities.
Prognosis:
The expected outcome or course of the condition over time.
Good with early treatment; delayed diagnosis can lead to severe complications or death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Multi-organ failure, disseminated intravascular coagulation (DIC), or long-term neurological deficits.
Spontaneous Bacterial Peritonitis (SBP)
Specialty: Infectious Diseases
Category: Bacterial Infections
Symptoms:
fever; abdominal pain; nausea; vomiting; altered mental status; diarrhea; low blood pressure; tachycardia
Root Cause:
Infection of the peritoneal fluid in patients with cirrhosis and ascites, often due to bacterial translocation from the gut.
How it's Diagnosed: videos
Diagnostic paracentesis showing ascitic fluid with polymorphonuclear leukocytes (PMN) >250 cells/mm³, positive bacterial cultures, and low protein levels in ascitic fluid.
Treatment:
Antibiotics, supportive care, and management of the underlying cirrhosis or liver disease.
Medications:
Empiric therapy typically includes third-generation cephalosporins (e.g., cefotaxime or ceftriaxone ). Fluoroquinolones (e.g., ciprofloxacin ) may be used for prophylaxis in high-risk patients.
Prevalence:
How common the health condition is within a specific population.
Affects 10-30% of patients with cirrhosis and ascites.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Advanced liver cirrhosis, low protein concentration in ascitic fluid, gastrointestinal bleeding, prior episodes of SBP.
Prognosis:
The expected outcome or course of the condition over time.
With prompt treatment, the mortality rate can be reduced, but the recurrence rate is high without prophylaxis.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Sepsis, hepatic encephalopathy, acute kidney injury, death.
Vibrio Infections
Specialty: Infectious Diseases
Category: Bacterial Infections
Sub-category: Waterborne Diseases
Symptoms:
watery diarrhea; abdominal cramps; vomiting; fever; skin infections (in vibrio vulnificus)
Root Cause:
Caused by Vibrio species (e.g., V. cholerae, V. vulnificus), often linked to contaminated water or seafood.
How it's Diagnosed: videos
Stool culture, PCR, or serology for specific strains.
Treatment:
Antibiotics for severe cases, oral rehydration therapy (ORT) or IV fluids.
Medications:
Doxycycline (tetracycline class); ciprofloxacin (fluoroquinolone class); azithromycin (macrolide antibiotic).
Prevalence:
How common the health condition is within a specific population.
Common in regions with cholera outbreaks; V. vulnificus infections are rare but severe.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Consumption of raw seafood, exposure to contaminated water, weakened immunity.
Prognosis:
The expected outcome or course of the condition over time.
Generally good with prompt treatment; V. vulnificus infections can be fatal in high-risk patients.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Severe dehydration (cholera), septicemia, necrotizing fasciitis (V. vulnificus).
Bacterial Meningitis (Empiric Therapy)
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
fever; neck stiffness; severe headache; nausea; vomiting; photophobia; altered mental status; seizures
Root Cause:
Acute inflammation of the meninges caused by bacterial infection.
How it's Diagnosed: videos
Clinical examination, lumbar puncture with cerebrospinal fluid (CSF) analysis (showing elevated white cell count, low glucose, and high protein), blood cultures, and imaging (CT or MRI if indicated).
Treatment:
Empiric antibiotic therapy (before the causative organism is identified), adjunctive corticosteroids, and supportive care.
Medications:
Empiric therapy often includes ceftriaxone or cefotaxime (3rd generation cephalosporins, broad-spectrum antibiotics), vancomycin (to cover resistant strains), and ampicillin (to cover Listeria monocytogenes in specific populations). Corticosteroids like dexamethasone are used to reduce inflammation.
Prevalence:
How common the health condition is within a specific population.
Incidence varies by region and age group; approximately 2-5 cases per 100,000 people annually in developed countries.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Immunosuppression, head trauma, invasive procedures, close contact with infected individuals, crowded living conditions, and extremes of age (infants and elderly).
Prognosis:
The expected outcome or course of the condition over time.
With prompt treatment, mortality is 5-30%, but delays in therapy significantly worsen outcomes. Neurological sequelae like hearing loss can occur.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Sepsis, increased intracranial pressure, stroke, seizures, and long-term neurological damage.
Bacterial Meningitis (Organism-Specific Therapy)
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
fever; neck stiffness; severe headache; nausea; vomiting; photophobia; altered mental status; seizures
Root Cause:
Inflammation of the meninges caused by specific bacterial pathogens like Neisseria meningitidis, Streptococcus pneumoniae, or Listeria monocytogenes.
How it's Diagnosed: videos
Identification of causative organism through cerebrospinal fluid (CSF) culture or polymerase chain reaction (PCR), blood cultures, and gram staining.
Treatment:
Targeted antibiotic therapy based on organism and susceptibility, adjunctive corticosteroids in certain cases, and supportive measures.
Medications:
For Neisseria meningitidis - Ceftriaxone or cefotaxime (3rd generation cephalosporins). For Streptococcus pneumoniae - Vancomycin plus ceftriaxone or cefotaxime . For Listeria monocytogenes - Ampicillin or penicillin G, often combined with gentamicin . Corticosteroids (e.g., dexamethasone ) to reduce inflammatory response in specific cases.
Prevalence:
How common the health condition is within a specific population.
Variable depending on region and vaccination coverage; more common in low-resource settings.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Age, immunodeficiency, lack of vaccination, recent head trauma or surgery, and close contact with infected individuals.
Prognosis:
The expected outcome or course of the condition over time.
Depends on early identification and treatment; targeted therapy improves outcomes, but significant mortality and morbidity can occur in severe cases.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Neurological deficits, hearing loss, hydrocephalus, brain abscess, or death.
California Encephalitis
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
fever; headache; nausea; vomiting; seizures; lethargy; meningeal irritation; neurological impairments in severe cases
Root Cause:
Viral infection caused by California serogroup viruses (e.g., La Crosse virus), primarily transmitted through mosquito bites.
How it's Diagnosed: videos
Clinical evaluation, lumbar puncture with cerebrospinal fluid (CSF) analysis, serologic or PCR testing for viral RNA.
Treatment:
Supportive care including antipyretics, anticonvulsants, and management of intracranial pressure.
Medications:
No specific antiviral therapy; symptomatic treatment includes antipyretics like acetaminophen and anticonvulsants like levetiracetam .
Prevalence:
How common the health condition is within a specific population.
Rare; typically affects children and adolescents in endemic regions of the United States.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Exposure to mosquito bites, residence in or travel to endemic areas, outdoor activities during peak mosquito seasons.
Prognosis:
The expected outcome or course of the condition over time.
Most cases resolve with supportive care, but severe cases may lead to neurological sequelae or death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Seizures, cognitive impairment, behavioral changes, or chronic neurological deficits in severe cases.
Cysticercosis (Pork Tapeworm Infection)
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
seizures; headaches; confusion; intracranial hypertension; vision changes; nausea; vomiting
Root Cause:
Infection with Taenia solium larvae, often acquired through ingestion of food or water contaminated with eggs of the pork tapeworm.
How it's Diagnosed: videos
MRI or CT scans to detect cysts in the brain, serologic tests (enzyme-linked immunoelectrotransfer blot), and patient history of exposure.
Treatment:
Combination of antiparasitic therapy, corticosteroids, and symptomatic treatment. Surgery may be required in some cases to remove cysts or relieve pressure.
Medications:
Antiparasitic medications include albendazole or praziquantel (antihelminthic drugs). Corticosteroids such as dexamethasone or prednisone are used to control inflammation. Antiepileptic drugs (e.g., phenytoin , carbamazepine ) are prescribed to manage seizures.
Prevalence:
How common the health condition is within a specific population.
Endemic in developing countries, particularly in areas with poor sanitation and where pigs are raised. Prevalence varies widely but is common in parts of Latin America, Africa, and Asia.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Consumption of undercooked pork, poor sanitation, exposure to feces contaminated with Taenia solium eggs.
Prognosis:
The expected outcome or course of the condition over time.
With prompt diagnosis and treatment, prognosis is generally good, although chronic neurological effects may persist in severe cases.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Hydrocephalus, chronic seizures, encephalitis, and death in severe untreated cases.
Eastern Equine Encephalitis (EEE)
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
high fever; stiff neck; severe headache; vomiting; drowsiness; confusion; seizures; coma
Root Cause:
Infection caused by the Eastern Equine Encephalitis virus (EEEV), transmitted through the bite of an infected mosquito.
How it's Diagnosed: videos
Diagnosis is made through serologic tests (detection of IgM antibodies in cerebrospinal fluid or serum), PCR, or viral isolation from samples.
Treatment:
Supportive care, including respiratory support, anticonvulsants for seizures, and fluids for dehydration. No specific antiviral treatment is available.
Medications:
No direct antiviral medications; symptomatic treatments include anticonvulsants (e.g., levetiracetam or valproic acid) and medications to manage complications such as swelling in the brain (e.g., mannitol or corticosteroids).
Prevalence:
How common the health condition is within a specific population.
Rare but more common in the eastern United States, primarily in areas with wetland habitats. Annual cases are low, typically fewer than 10 per year in the U.S.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Living in or traveling to areas with high mosquito populations, outdoor exposure without protective measures.
Prognosis:
The expected outcome or course of the condition over time.
High mortality rate (approximately 30%); survivors often have long-term neurological sequelae.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Severe neurological damage, paralysis, intellectual disability, and death.
Haemophilus Meningitis
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
fever; stiff neck; headache; nausea; vomiting; sensitivity to light; altered mental status; seizures
Root Cause:
Bacterial infection caused by Haemophilus influenzae type b (Hib), leading to inflammation of the meninges.
How it's Diagnosed: videos
Lumbar puncture for cerebrospinal fluid analysis, Gram staining, and culture; PCR tests for Hib DNA.
Treatment:
Intravenous antibiotics and supportive care.
Medications:
Third-generation cephalosporins like ceftriaxone or cefotaxime are the antibiotics of choice. Adjunctive dexamethasone may be used to reduce inflammation.
Prevalence:
How common the health condition is within a specific population.
Rare in countries with widespread Hib vaccination; still occurs in unvaccinated populations or areas with low vaccine coverage.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Lack of vaccination, young age (children under 5), weakened immune system.
Prognosis:
The expected outcome or course of the condition over time.
With prompt antibiotic treatment, prognosis is good, although complications such as hearing loss may occur.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Hearing loss, intellectual disability, seizures, and death if untreated.
Naegleria Infection and Primary Amebic Meningoencephalitis (PAM)
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
severe headache; fever; nausea; vomiting; stiff neck; seizures; altered mental status; hallucinations; coma
Root Cause:
Infection caused by the amoeba Naegleria fowleri, which invades the brain through the nasal passages, often following freshwater exposure.
How it's Diagnosed: videos
Analysis of cerebrospinal fluid (CSF) through lumbar puncture, identification of Naegleria in CSF via microscopy, polymerase chain reaction (PCR), or antigen testing; brain imaging (MRI or CT) for inflammation.
Treatment:
Aggressive antimicrobial therapy including amphotericin B (intravenous and intrathecal), supportive care for cerebral edema, and experimental medications like miltefosine.
Medications:
Amphotericin B (antifungal), miltefosine (antiparasitic), rifampin (antibiotic), fluconazole (antifungal), and azithromycin (antibiotic). These medications aim to target the amoeba directly and reduce associated inflammation.
Prevalence:
How common the health condition is within a specific population.
Rare; fewer than 150 cases reported in the United States over several decades. Occurs more frequently in warm climates with freshwater exposure.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Freshwater swimming or diving, particularly in warm lakes or hot springs; use of untreated water for nasal irrigation.
Prognosis:
The expected outcome or course of the condition over time.
Poor, with a mortality rate exceeding 97%; early diagnosis and treatment are critical for the few known survivors.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Rapidly progressing brain inflammation, brain herniation, coma, and death.
Neonatal Meningitis
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
fever; lethargy; poor feeding; irritability; seizures; bulging fontanel; stiff neck; vomiting; difficulty breathing
Root Cause:
Bacterial or viral infection in the meninges of the brain and spinal cord, often caused by pathogens like Group B Streptococcus, E. coli, or Listeria monocytogenes.
How it's Diagnosed: videos
Lumbar puncture for CSF analysis (elevated white cells, protein, decreased glucose), blood cultures, neuroimaging (MRI or CT), and specific PCR tests for pathogens.
Treatment:
Intravenous broad-spectrum antibiotics (e.g., ampicillin and gentamicin) followed by pathogen-specific therapy; antiviral medications for viral causes; supportive care for seizures and hydration.
Medications:
Antibiotics such as ampicillin (penicillin class), gentamicin (aminoglycoside), cefotaxime (cephalosporin), and acyclovir (antiviral for suspected herpes infection).
Prevalence:
How common the health condition is within a specific population.
Occurs in 1-3 cases per 1,000 live births in developed countries, higher prevalence in low-resource settings.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Premature birth, maternal infection, prolonged labor, low birth weight, and exposure to group B strep during delivery.
Prognosis:
The expected outcome or course of the condition over time.
Variable; high risk of mortality (10-15%) and neurodevelopmental sequelae in survivors (e.g., hearing loss, cerebral palsy).
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Sepsis, brain abscesses, hydrocephalus, and developmental delays.
Staphylococcal Meningitis
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
fever; severe headache; neck stiffness; nausea; vomiting; altered mental status; seizures
Root Cause:
Infection of the meninges caused by Staphylococcus aureus or other staphylococcal species, often following surgery, trauma, or bacteremia.
How it's Diagnosed: videos
Lumbar puncture with CSF analysis; Gram staining and culture; blood cultures.
Treatment:
Intravenous antibiotics tailored to culture sensitivity.
Medications:
Empiric therapy often includes vancomycin (glycopeptide) combined with ceftriaxone or meropenem (carbapenem). Adjusted based on susceptibility.
Prevalence:
How common the health condition is within a specific population.
Rare; higher in healthcare-associated settings.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Neurosurgery, trauma, immunosuppression, systemic staphylococcal infections.
Prognosis:
The expected outcome or course of the condition over time.
Good with early treatment; poor in untreated or advanced cases.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Brain abscesses, hearing loss, neurological deficits, septic shock.
Tuberculous Meningitis
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
headache; fever; nausea; vomiting; stiff neck; altered mental status; seizures
Root Cause:
Infection of the meninges by Mycobacterium tuberculosis, leading to inflammation and increased intracranial pressure.
How it's Diagnosed: videos
Lumbar puncture with CSF analysis (increased protein, low glucose, and lymphocytic predominance), imaging (MRI or CT), and microbiological tests for M. tuberculosis.
Treatment:
Long-term combination antitubercular therapy (e.g., isoniazid, rifampin, pyrazinamide, ethambutol), corticosteroids to reduce inflammation, and supportive care.
Medications:
First-line antitubercular drugs (e.g., isoniazid , rifampin ); corticosteroids (e.g., dexamethasone ) to manage inflammation.
Prevalence:
How common the health condition is within a specific population.
More common in areas with high TB burden; rare in developed countries.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
HIV infection, immunosuppression, close contact with TB patients, malnutrition.
Prognosis:
The expected outcome or course of the condition over time.
With early treatment, survival is possible, but delayed therapy can result in high morbidity and mortality.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Hydrocephalus, stroke, cranial nerve palsies, cognitive deficits, and death if untreated.
Venezuelan Equine Encephalitis
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
fever; headache; nausea; vomiting; seizures; confusion; weakness; photophobia
Root Cause:
Caused by the Venezuelan equine encephalitis virus, transmitted by mosquitoes, leading to inflammation of the brain.
How it's Diagnosed: videos
Serologic tests for viral antibodies (e.g., ELISA), PCR for viral RNA, and CSF analysis.
Treatment:
Supportive care (e.g., hydration, antipyretics, and seizure control); no specific antiviral treatment available.
Medications:
Antipyretics (e.g., acetaminophen for fever); anticonvulsants (e.g., phenytoin or valproic acid for seizures).
Prevalence:
How common the health condition is within a specific population.
Sporadic outbreaks in Central and South America; rare in humans, more common in equines.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Living or working in endemic areas, exposure to mosquitoes, and outdoor activities.
Prognosis:
The expected outcome or course of the condition over time.
Most recover fully, but severe cases may lead to neurological deficits or death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Long-term neurological sequelae (e.g., cognitive deficits, epilepsy), and in severe cases, death.
Viral Encephalitis
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
fever; headache; confusion; seizures; nausea; vomiting; altered mental status; photophobia
Root Cause:
Brain inflammation caused by viral infections (e.g., herpes simplex virus, arboviruses), leading to neuronal damage.
How it's Diagnosed: videos
Clinical evaluation, CSF analysis, PCR for viral DNA/RNA, and neuroimaging (e.g., MRI).
Treatment:
Antiviral therapy for specific viruses (e.g., acyclovir for herpes simplex virus); supportive care for other viral causes.
Medications:
Acyclovir (for herpes simplex); antipyretics (e.g., ibuprofen for fever); anticonvulsants (e.g., levetiracetam for seizures).
Prevalence:
How common the health condition is within a specific population.
Varies; common in areas with high mosquito-borne virus activity or sporadic herpes outbreaks.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Immunosuppression, unvaccinated status, and mosquito exposure.
Prognosis:
The expected outcome or course of the condition over time.
Depends on the cause and severity; early treatment improves outcomes, but severe cases may result in lasting deficits.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Long-term neurological damage, seizures, cognitive deficits, and death if untreated.
Viral Meningitis
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
headache; fever; neck stiffness; photophobia; nausea; vomiting
Root Cause:
Inflammation of the meninges caused by viral infections (e.g., enteroviruses, herpesviruses), leading to non-purulent inflammation.
How it's Diagnosed: videos
CSF analysis (increased lymphocytes, normal glucose, elevated protein), PCR for viral pathogens.
Treatment:
Supportive care (hydration, pain relief, antipyretics); antiviral therapy for specific causes (e.g., herpesvirus).
Medications:
Acyclovir (for herpes-related cases); over-the-counter analgesics (e.g., acetaminophen for headache and fever).
Prevalence:
How common the health condition is within a specific population.
Common; most cases are mild and self-limiting.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Exposure to infected individuals, immunosuppression, and travel to endemic regions.
Prognosis:
The expected outcome or course of the condition over time.
Excellent in most cases; severe outcomes are rare.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Rare; may include chronic headaches or recurrent symptoms.
Western Equine Encephalitis (WEE)
Specialty: Infectious Diseases
Category: CNS Infections
Symptoms:
fever; headache; nausea; vomiting; seizures; altered mental status; muscle weakness
Root Cause:
Caused by the Western equine encephalitis virus, transmitted by mosquitoes, leading to inflammation of the brain and central nervous system.
How it's Diagnosed: videos
Serologic testing for viral antibodies (e.g., IgM ELISA), PCR for viral RNA, and CSF analysis.
Treatment:
Supportive care (e.g., intravenous fluids, fever control, seizure management); no specific antiviral therapy available.
Medications:
Antipyretics (e.g., ibuprofen for fever and discomfort); anticonvulsants (e.g., diazepam or levetiracetam for seizure control).
Prevalence:
How common the health condition is within a specific population.
Rare; found in North and South America, with sporadic outbreaks in rural areas.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Exposure to mosquitoes in endemic regions, outdoor activities, and lack of mosquito control.
Prognosis:
The expected outcome or course of the condition over time.
Most cases are mild and resolve without long-term effects; severe cases can lead to neurological deficits or death, particularly in children and the elderly.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Long-term neurological deficits (e.g., cognitive impairment, motor dysfunction), seizures, and death in severe cases.
Cryptococcosis
Specialty: Infectious Diseases
Category: Fungal Infections
Sub-category: Opportunistic Mycoses
Symptoms:
fever; headache; nausea; vomiting; altered mental status; neck stiffness in meningitis; cough; chest pain
Root Cause:
Infection by Cryptococcus neoformans or Cryptococcus gattii, typically through inhalation of spores, often affecting immunocompromised individuals.
How it's Diagnosed: videos
India ink staining, cryptococcal antigen testing, fungal cultures, or molecular diagnostics.
Treatment:
Induction therapy with amphotericin B and flucytosine, followed by maintenance therapy with fluconazole.
Medications:
Amphotericin B (polyenes), flucytosine (antifungal antimetabolite), and fluconazole (azole antifungal). These target fungal membranes or DNA synthesis.
Prevalence:
How common the health condition is within a specific population.
Common opportunistic infection in HIV/AIDS patients, with significant global burden in low-resource settings.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
HIV/AIDS, organ transplantation, corticosteroid use, and other immunosuppressive conditions.
Prognosis:
The expected outcome or course of the condition over time.
Early treatment significantly improves outcomes, though CNS involvement can lead to high mortality (up to 70% in severe untreated cases).
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Cryptococcal meningitis, hydrocephalus, vision loss, and neurological deficits.
Bacterial Gastroenteritis
Specialty: Infectious Diseases
Category: Gastrointestinal Tract and Intra-abdominal Infections
Symptoms:
diarrhea (often watery or bloody); abdominal cramps; fever; nausea; vomiting; dehydration
Root Cause:
Infection of the gastrointestinal tract caused by pathogenic bacteria like Salmonella, Shigella, Escherichia coli, or Campylobacter.
How it's Diagnosed: videos
Stool cultures, stool antigen tests, and molecular testing (PCR) to identify bacterial pathogens; clinical history of recent travel or food exposure.
Treatment:
Rehydration therapy (oral or intravenous), dietary adjustments, and in severe cases, antibiotics depending on the pathogen.
Medications:
Antibiotics like ciprofloxacin (fluoroquinolone) or azithromycin (macrolide) are used for severe infections. Oral rehydration solutions (ORS) and zinc supplementation help manage dehydration.
Prevalence:
How common the health condition is within a specific population.
A common cause of morbidity worldwide, particularly in low-resource settings; affects millions annually, especially children under five.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Contaminated food or water, poor hygiene, travel to endemic areas, and immunocompromised states.
Prognosis:
The expected outcome or course of the condition over time.
Usually self-limiting; severe cases may lead to complications without prompt treatment.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Severe dehydration, hemolytic uremic syndrome (HUS), and reactive arthritis.
Hepatitis A
Specialty: Infectious Diseases
Category: Liver Infections
Sub-category: Acute Viral Hepatitis
Symptoms:
fatigue; nausea; vomiting; abdominal pain; jaundice; dark urine; pale stools; fever
Root Cause:
Infection with the Hepatitis A virus (HAV) causing inflammation of the liver; spread primarily through contaminated food and water.
How it's Diagnosed: videos
Blood tests detecting HAV-specific IgM antibodies, liver function tests.
Treatment:
Primarily supportive care (rest, hydration, avoiding alcohol); no specific antiviral therapy.
Medications:
No antiviral medications; symptomatic relief with antipyretics (e.g., acetaminophen for fever) or antiemetics for nausea.
Prevalence:
How common the health condition is within a specific population.
Common in areas with poor sanitation; estimated 1.4 million cases worldwide annually.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Travel to endemic regions, consuming contaminated food or water, close contact with an infected person.
Prognosis:
The expected outcome or course of the condition over time.
Full recovery in most cases within weeks to months; no chronic infection.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Rare, but can include fulminant hepatitis in older adults or those with pre-existing liver conditions.
Pancreatic Necrosis and Pancreatic Abscess
Specialty: Infectious Diseases
Category: Gastrointestinal Tract and Intra-abdominal Infections
Symptoms:
severe abdominal pain; fever; nausea; vomiting; abdominal tenderness; tachycardia; jaundice in severe cases
Root Cause:
Pancreatic necrosis involves the death of pancreatic tissue due to severe inflammation or infection, often following acute pancreatitis. Pancreatic abscess is a collection of pus resulting from infected necrotic tissue or fluid accumulation.
How it's Diagnosed: videos
Diagnosed through clinical evaluation, imaging studies (CT scan or MRI), and blood tests including elevated white blood cell count, CRP, and amylase/lipase levels. Fine-needle aspiration (FNA) may confirm infection.
Treatment:
Treatment includes supportive care, drainage of abscesses, and, in severe cases, surgical debridement or necrosectomy. Antibiotics are used to manage infections.
Medications:
Antibiotics such as carbapenems (e.g., meropenem ), third-generation cephalosporins (e.g., ceftriaxone ), or fluoroquinolones (e.g., ciprofloxacin ) combined with metronidazole to cover anaerobes. These are classified as broad-spectrum antibiotics. Pain management includes opioids like morphine or hydromorphone .
Prevalence:
How common the health condition is within a specific population.
Rare but occurs in 10-20% of cases of severe acute pancreatitis.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Alcohol abuse, gallstones, hyperlipidemia, pancreatic trauma, and delayed or inadequate treatment of acute pancreatitis.
Prognosis:
The expected outcome or course of the condition over time.
Prognosis depends on early diagnosis and treatment. Mortality rates can reach 30-50% in cases of infected necrosis or untreated abscesses.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Sepsis, multiorgan failure, hemorrhage, diabetes mellitus, and chronic pancreatitis.
Salmonella Infection (Salmonellosis)
Specialty: Infectious Diseases
Category: Gastrointestinal Tract and Intra-abdominal Infections
Symptoms:
diarrhea; fever; abdominal cramps; nausea; vomiting; headache
Root Cause:
Infection by Salmonella bacteria, typically via contaminated food, water, or contact with infected animals.
How it's Diagnosed: videos
Stool culture, blood culture in severe cases, and molecular testing (PCR) to identify Salmonella species.
Treatment:
Supportive care with fluids and electrolytes; antibiotics (only for severe cases).
Medications:
Antibiotics like ciprofloxacin , azithromycin , or ceftriaxone for severe or systemic infections. These are classified as fluoroquinolones, macrolides, and third-generation cephalosporins, respectively.
Prevalence:
How common the health condition is within a specific population.
Common worldwide; significant in developing regions due to poor sanitation.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Consumption of contaminated food, immunosuppression, and travel to endemic regions.
Prognosis:
The expected outcome or course of the condition over time.
Self-limited in most cases; good with appropriate treatment for severe cases.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Dehydration, bacteremia, reactive arthritis, and localized infections (e.g., osteomyelitis).
Small Intestinal Diverticulosis
Specialty: Infectious Diseases
Category: Gastrointestinal Tract and Intra-abdominal Infections
Symptoms:
abdominal discomfort; bloating; nausea; vomiting; diarrhea or constipation; occult gastrointestinal bleeding in some cases
Root Cause:
Formation of diverticula (small pouches) in the small intestine, often due to increased intraluminal pressure or connective tissue weakness.
How it's Diagnosed: videos
Radiographic imaging (CT scan, small bowel follow-through, or capsule endoscopy) and incidental findings during evaluations for other conditions.
Treatment:
Mostly asymptomatic; dietary modifications and antibiotics for diverticulitis. Surgery in cases of complications like perforation.
Medications:
Antibiotics such as ciprofloxacin and metronidazole for diverticulitis. Prokinetics may be used for motility issues.
Prevalence:
How common the health condition is within a specific population.
Rare; increases with age.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Older age, connective tissue disorders, and motility disorders.
Prognosis:
The expected outcome or course of the condition over time.
Good in asymptomatic cases; complications may worsen outcomes.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Diverticulitis, perforation, fistula, and small bowel obstruction.
Viral Gastroenteritis
Specialty: Infectious Diseases
Category: Gastrointestinal Tract and Intra-abdominal Infections
Symptoms:
watery diarrhea; nausea; vomiting; fever; abdominal cramps; dehydration
Root Cause:
Inflammation of the stomach and intestines caused by viral infections (e.g., norovirus, rotavirus, adenovirus).
How it's Diagnosed: videos
Clinical diagnosis based on symptoms; stool PCR or antigen tests in specific cases.
Treatment:
Supportive care, including rehydration and electrolyte replacement. Antiemetics may be used for severe nausea.
Medications:
No specific antiviral treatment; oral rehydration solutions (ORS) and antiemetics like ondansetron may be used.
Prevalence:
How common the health condition is within a specific population.
Very common worldwide, especially in children and in areas with poor sanitation.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Close contact with infected individuals, contaminated food or water, poor hand hygiene.
Prognosis:
The expected outcome or course of the condition over time.
Excellent in most cases with supportive care; severe dehydration can be life-threatening without treatment.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Dehydration, electrolyte imbalances, and in rare cases, kidney injury.
Yellow Fever
Specialty: Infectious Diseases
Category: Gastrointestinal Tract and Intra-abdominal Infections
Symptoms:
fever; headache; muscle pain; nausea; vomiting; jaundice; abdominal pain; bleeding (e.g., from the gums or nose); organ failure in severe cases
Root Cause:
Yellow fever is caused by the yellow fever virus, a flavivirus transmitted by infected mosquitoes (primarily Aedes aegypti). It leads to systemic infection, liver damage, and subsequent jaundice and bleeding tendencies in severe cases.
How it's Diagnosed: videos
Diagnosed through serologic tests or PCR.
Treatment:
Treated supportively, as no specific antiviral therapy exists, with vaccination as a key preventive measure.
Medications:
No antiviral medications are available for yellow fever. Supportive medications include antipyretics like acetaminophen (avoid NSAIDs like ibuprofen or aspirin to reduce bleeding risks) and intravenous fluids for dehydration. Hemostatic agents may be used in cases of severe bleeding.
Prevalence:
How common the health condition is within a specific population.
Yellow fever is endemic in tropical areas of Africa and South America. Annually, it causes an estimated 200,000 cases and 30,000 deaths globally, with most cases unreported.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Traveling to or living in endemic areas, lack of vaccination, and exposure to mosquito bites.
Prognosis:
The expected outcome or course of the condition over time.
In mild cases, recovery occurs within days to weeks without long-term effects. Severe cases with complications like liver failure or bleeding have a mortality rate of 20–50%. Survivors of severe cases typically recover fully but may require prolonged convalescence.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Hepatic failure, renal failure, shock, disseminated intravascular coagulation (DIC), multi-organ failure, and death in severe cases.
Pyonephrosis
Specialty: Infectious Diseases
Category: Genitourinary Tract Infections
Symptoms:
fever; flank pain; chills; nausea; vomiting; cloudy or foul-smelling urine
Root Cause:
Accumulation of pus in the renal collecting system, often caused by an obstructive uropathy combined with infection.
How it's Diagnosed: videos
Ultrasound or CT imaging to detect hydronephrosis with echogenic debris; urine culture to identify infection; blood tests to check for systemic infection.
Treatment:
Drainage of pus through percutaneous nephrostomy or surgery; broad-spectrum antibiotics followed by culture-guided antibiotics.
Medications:
Broad-spectrum antibiotics such as piperacillin-tazobactam (beta-lactam/beta-lactamase inhibitor), carbapenems (e.g., meropenem ), or fluoroquinolones (e.g., ciprofloxacin ).
Prevalence:
How common the health condition is within a specific population.
Rare; more common in patients with urinary obstruction or immunocompromised states.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Kidney stones, urinary tract obstruction, diabetes, immunosuppression, prior urinary infections.
Prognosis:
The expected outcome or course of the condition over time.
Good with timely drainage and appropriate antibiotics; untreated cases can lead to sepsis and renal failure.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Sepsis, renal abscess, permanent kidney damage, or renal failure.
CNS Cryptococcosis in HIV
Specialty: Infectious Diseases
Category: Central Nervous System Complications in HIV
Symptoms:
headache; fever; nausea; vomiting; stiff neck; photophobia; altered mental status
Root Cause:
Opportunistic fungal infection caused by Cryptococcus neoformans or Cryptococcus gattii in immunocompromised individuals.
How it's Diagnosed: videos
CSF analysis with India ink staining, cryptococcal antigen test, fungal culture, and MRI/CT imaging for associated findings.
Treatment:
Initial treatment with amphotericin B and flucytosine for induction therapy, followed by fluconazole for consolidation and maintenance therapy; concurrent ART for HIV management.
Medications:
Amphotericin B (antifungal polyene), flucytosine (antifungal antimetabolite), fluconazole (azole antifungal).
Prevalence:
How common the health condition is within a specific population.
Common in HIV patients with CD4 counts <100 cells/mm³, particularly in resource-limited settings.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Advanced HIV, environmental exposure to cryptococcal spores, lack of ART adherence.
Prognosis:
The expected outcome or course of the condition over time.
High mortality if untreated; with prompt therapy, survival rates improve, though neurological sequelae may persist.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Increased intracranial pressure, hydrocephalus, and long-term cognitive deficits.
Middle East Respiratory Syndrome (MERS)
Specialty: Infectious Diseases
Category: Lower Respiratory Tract Infections
Symptoms:
fever; cough; shortness of breath; muscle pain; nausea; vomiting; diarrhea; abdominal pain
Root Cause:
Caused by the MERS-CoV coronavirus, transmitted through respiratory droplets or contact with infected individuals or camels. Severe cases involve acute respiratory distress syndrome (ARDS).
How it's Diagnosed: videos
Diagnosis is based on PCR testing for MERS-CoV in respiratory samples, chest imaging to detect pneumonia or ARDS, and serologic tests.
Treatment:
Supportive care, including oxygen therapy, mechanical ventilation in severe cases, and treatment of secondary infections. No specific antiviral therapy is widely accepted.
Medications:
Experimental - Antivirals (e.g., ribavirin ) combined with interferon have been investigated but are not standard treatments. Supportive medications - Antipyretics for fever, and bronchodilators for respiratory relief.
Prevalence:
How common the health condition is within a specific population.
Outbreaks have primarily occurred in the Middle East. Limited cases in other regions due to travel-associated spread. Mortality rates range from 30-40%.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Close contact with camels, healthcare exposure to infected individuals, age over 50, pre-existing chronic diseases (e.g., diabetes, heart disease).
Prognosis:
The expected outcome or course of the condition over time.
Severe cases can progress to multi-organ failure and death, particularly in high-risk groups. Mild cases may resolve with symptomatic management.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
ARDS, septic shock, renal failure, and long-term pulmonary complications in survivors.
Psittacosis (Parrot Fever)
Specialty: Infectious Diseases
Category: Lower Respiratory Tract Infections
Symptoms:
fever; chills; headache; dry cough; muscle aches; shortness of breath; nausea; vomiting; fatigue
Root Cause:
Zoonotic infection caused by Chlamydia psittaci, typically transmitted through inhalation of dried droppings, secretions, or dust from infected birds.
How it's Diagnosed: videos
Diagnosis involves serologic testing for C. psittaci antibodies, PCR testing, and chest imaging to confirm pneumonia.
Treatment:
Antibiotic therapy is the primary treatment, often combined with supportive care for symptom relief.
Medications:
Antibiotics - Tetracyclines (e.g., doxycycline ) are the treatment of choice. Macrolides (e.g., azithromycin ) may be used as an alternative.
Prevalence:
How common the health condition is within a specific population.
Rare, primarily affecting individuals in close contact with birds, such as pet owners, veterinarians, and bird handlers.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Exposure to infected birds, handling bird droppings, or working in environments with birds.
Prognosis:
The expected outcome or course of the condition over time.
Good with appropriate treatment; most patients recover fully. Untreated cases can lead to severe complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Endocarditis, myocarditis, respiratory failure, and multi-organ dysfunction in severe cases.
Ascariasis
Specialty: Infectious Diseases
Category: Parasitic Infections
Symptoms:
abdominal pain; nausea; vomiting; malnutrition; intestinal blockage; cough (during larval migration)
Root Cause:
Infection with Ascaris lumbricoides, a roundworm transmitted through ingestion of eggs from contaminated soil or food.
How it's Diagnosed: videos
Stool analysis for eggs, imaging studies for intestinal obstruction, and sometimes ultrasound or CT for heavy infections.
Treatment:
Anthelmintic medications, sometimes surgery for complications.
Medications:
Albendazole or mebendazole are commonly prescribed; pyrantel pamoate is an alternative.
Prevalence:
How common the health condition is within a specific population.
Highly prevalent in tropical and subtropical regions, especially in areas with poor sanitation.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Contaminated soil or water, poor hygiene, and living in endemic areas.
Prognosis:
The expected outcome or course of the condition over time.
Excellent with treatment; severe cases with complications may require additional interventions.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Intestinal obstruction, malnutrition, growth retardation in children, and migration of worms to other organs.
Balantidiasis
Specialty: Infectious Diseases
Category: Parasitic Infections
Symptoms:
diarrhea; abdominal pain; nausea; vomiting; fever; weight loss
Root Cause:
Infection with Balantidium coli, a ciliate protozoan, typically acquired from contaminated food or water.
How it's Diagnosed: videos
Stool examination for trophozoites or cysts; rarely, colonoscopy and biopsy.
Treatment:
Antiprotozoal therapy.
Medications:
Tetracycline is the first-line treatment; metronidazole or iodoquinol are alternatives.
Prevalence:
How common the health condition is within a specific population.
Rare, typically found in areas with poor sanitation and exposure to swine.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Close contact with pigs, contaminated water, and poor hygiene.
Prognosis:
The expected outcome or course of the condition over time.
Good with treatment; untreated severe cases may lead to complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Perforation of the colon, peritonitis.
Cryptosporidiosis
Specialty: Infectious Diseases
Category: Parasitic Infections
Symptoms:
watery diarrhea; abdominal pain; nausea; vomiting; fever; weight loss; dehydration
Root Cause:
Infection with Cryptosporidium species, primarily transmitted through ingestion of contaminated water or food.
How it's Diagnosed: videos
Stool analysis using acid-fast staining, direct fluorescent antibody tests, or PCR for Cryptosporidium DNA.
Treatment:
Supportive care to prevent dehydration; specific antiparasitic therapy for immunocompromised individuals.
Medications:
Nitazoxanide (antiprotozoal) is the primary treatment. Antidiarrheal agents may be used for symptom control.
Prevalence:
How common the health condition is within a specific population.
Common worldwide, especially in children and immunocompromised individuals in low-resource settings.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Contaminated water sources, poor sanitation, immunosuppression (e.g., HIV/AIDS).
Prognosis:
The expected outcome or course of the condition over time.
Good for immunocompetent individuals; chronic or severe disease in immunosuppressed patients.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Severe dehydration, malnutrition, and chronic diarrhea in immunocompromised individuals.
Cystoisosporiasis
Specialty: Infectious Diseases
Category: Parasitic Infections
Symptoms:
watery diarrhea; abdominal pain; cramping; nausea; vomiting; weight loss; fever
Root Cause:
Infection with Cystoisospora belli (formerly known as Isospora belli), a parasitic protozoan that invades the epithelial cells of the small intestine.
How it's Diagnosed: videos
Microscopic examination of stool samples to detect oocysts; acid-fast staining or molecular tests (e.g., PCR) may be used.
Treatment:
Primarily with antiparasitic medication and supportive care (rehydration and nutritional support).
Medications:
Trimethoprim-sulfamethoxazole (antibiotic combination, also known as Bactrim ) is the first-line treatment. For sulfa-allergic patients, pyrimethamine with leucovorin (folic acid) may be used.
Prevalence:
How common the health condition is within a specific population.
Rare in developed countries; more common in tropical and subtropical regions and in immunocompromised individuals (e.g., HIV/AIDS).
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Immunosuppression, travel to or residence in endemic areas, poor sanitation, consumption of contaminated food or water.
Prognosis:
The expected outcome or course of the condition over time.
Good with prompt treatment; chronic or recurrent infections may occur in immunocompromised patients.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic diarrhea, malabsorption, dehydration, and significant weight loss, especially in immunocompromised individuals.
Echinococcosis (Hydatid Cyst)
Specialty: Infectious Diseases
Category: Parasitic Infections
Symptoms:
abdominal pain; nausea; vomiting; cyst-related pressure effects; allergic reactions if the cyst ruptures
Root Cause:
Infection with Echinococcus granulosus or Echinococcus multilocularis, causing cystic or alveolar echinococcosis, respectively.
How it's Diagnosed: videos
Imaging studies (ultrasound, CT, or MRI), serological tests (ELISA, Western blot), and histopathological examination.
Treatment:
Surgical removal of cysts, percutaneous aspiration (PAIR technique), or antiparasitic drug therapy for inoperable cases.
Medications:
Albendazole and mebendazole (anthelmintics) are used to reduce cyst size or as adjuncts to surgery.
Prevalence:
How common the health condition is within a specific population.
Endemic in sheep-raising regions such as the Middle East, Central Asia, South America, and parts of Africa.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Contact with infected dogs, livestock farming, poor hygiene practices.
Prognosis:
The expected outcome or course of the condition over time.
Variable; excellent with early intervention, but alveolar echinococcosis can be life-threatening if untreated.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Cyst rupture leading to anaphylaxis, secondary bacterial infections, or dissemination of the infection.
Malaria
Specialty: Infectious Diseases
Category: Parasitic Infections
Symptoms:
fever; chills; headache; nausea; vomiting; muscle pain; anemia; sweating; enlarged spleen
Root Cause:
Infection by Plasmodium parasites (e.g., P. falciparum, P. vivax) transmitted by infected Anopheles mosquitoes.
How it's Diagnosed: videos
Microscopy (blood smears), rapid diagnostic tests (RDTs), and polymerase chain reaction (PCR).
Treatment:
Antimalarial medications, supportive care for complications (e.g., blood transfusions for severe anemia).
Medications:
Artemisinin-based combination therapies (ACTs, e.g., artemether-lumefantrine), chloroquine (for chloroquine-sensitive strains), primaquine (for liver-stage hypnozoites), atovaquone-proguanil, and quinine .
Prevalence:
How common the health condition is within a specific population.
Affects 240 million people annually, with the highest burden in sub-Saharan Africa.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Living in endemic areas, lack of insecticide-treated bed nets, poverty, and pregnancy.
Prognosis:
The expected outcome or course of the condition over time.
Treatable, but severe malaria can cause death if untreated, especially in children and pregnant women.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Cerebral malaria, severe anemia, organ failure, and hypoglycemia.
Malaria Organism-Specific Therapy
Specialty: Infectious Diseases
Category: Parasitic Infections
Symptoms:
fever; chills; sweating; headache; nausea; vomiting; muscle aches; anemia
Root Cause:
Infection caused by specific Plasmodium species (P. falciparum, P. vivax, P. ovale, P. malariae, or P. knowlesi). Treatment tailored to the infecting species, drug resistance, and location.
How it's Diagnosed: videos
Microscopy, species-specific rapid diagnostic tests (RDTs), and PCR.
Treatment:
Therapy varies by species; includes addressing blood-stage parasites and dormant liver stages (P. vivax and P. ovale).
Medications:
P. falciparum - Artemisinin-based combination therapies (ACTs, e.g., artemether-lumefantrine). P. vivax - Chloroquine or ACTs for blood-stage; primaquine or tafenoquine for liver-stage hypnozoites. P. malariae and P. ovale - Similar to P. vivax protocols. P. knowlesi - Treated with ACTs or chloroquine .
Prevalence:
How common the health condition is within a specific population.
Regional variations; P. falciparum most common in Africa, P. vivax predominant outside sub-Saharan Africa.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Traveling or living in endemic areas, lack of preventive measures (e.g., bed nets, prophylaxis).
Prognosis:
The expected outcome or course of the condition over time.
Effective treatment reduces mortality; early diagnosis critical. Untreated cases can lead to severe complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Severe malaria, organ failure, cerebral malaria, hypoglycemia.
Microsporidiosis
Specialty: Infectious Diseases
Category: Parasitic Infections
Symptoms:
chronic diarrhea; abdominal pain; weight loss; nausea; vomiting; fever; ocular inflammation (in cases of eye involvement)
Root Cause:
Caused by microsporidia, intracellular parasites primarily affecting immunocompromised individuals.
How it's Diagnosed: videos
Microscopy (modified trichrome stain), PCR, and electron microscopy.
Treatment:
Antiparasitic medications, rehydration therapy, and managing underlying immunosuppression.
Medications:
Albendazole (a broad-spectrum antiparasitic) for systemic infections; fumagillin or topical agents for ocular infections.
Prevalence:
How common the health condition is within a specific population.
Found worldwide, particularly in HIV/AIDS patients and organ transplant recipients.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Immunosuppression (e.g., HIV/AIDS, chemotherapy), exposure to contaminated water or food.
Prognosis:
The expected outcome or course of the condition over time.
Treatable, but complications are more severe in immunocompromised individuals.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic malabsorption, systemic spread, and severe organ-specific infections.
Arenaviruses
Specialty: Infectious Diseases
Category: Viral Infections
Symptoms:
fever; headache; myalgia; nausea; vomiting; hemorrhagic symptoms in severe cases
Root Cause:
Caused by arenaviruses, which are RNA viruses transmitted through rodent hosts. Some species can cause hemorrhagic fevers.
How it's Diagnosed: videos
PCR testing, serological testing, and virus isolation in specialized laboratories.
Treatment:
Supportive care; ribavirin (an antiviral medication) may be used in some cases.
Medications:
Ribavirin , an antiviral agent classified as a nucleoside analog.
Prevalence:
How common the health condition is within a specific population.
Rare but can occur in endemic regions where rodent reservoirs are prevalent.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Exposure to infected rodents, living in endemic areas, poor sanitation.
Prognosis:
The expected outcome or course of the condition over time.
Depends on the specific arenavirus; Lassa fever has a case fatality rate of 1-15%. Early treatment improves outcomes.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Hemorrhagic fever, multi-organ failure, and death in severe cases.
Smallpox
Specialty: Infectious Diseases
Category: COVID-19 Reinfections
Symptoms:
high fever; rash that progresses from spots to fluid-filled blisters; headache; backache; vomiting; fatigue
Root Cause:
Caused by the variola virus, leading to severe systemic infection with a characteristic skin rash.
How it's Diagnosed: videos
Clinical diagnosis based on the characteristic rash and fever pattern; PCR testing can confirm the variola virus.
Treatment:
No specific antiviral treatment. Smallpox was eradicated in 1980 through vaccination. Supportive care for those affected.
Medications:
Antiviral treatments like tecovirimat (TPOXX), classified as an antiviral medication, are used in some cases under emergency protocols.
Prevalence:
How common the health condition is within a specific population.
Smallpox was eradicated in 1980 and is no longer a public health threat.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Lack of vaccination, close contact with infected individuals.
Prognosis:
The expected outcome or course of the condition over time.
Smallpox has been eradicated, but untreated infections historically had a high mortality rate.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Secondary bacterial infections, blindness, scarring, death.
Ebola Virus Infection
Specialty: Infectious Diseases
Category: Viral Hemorrhagic Fevers
Sub-category: Filoviruses
Symptoms:
fever; severe headache; muscle pain; fatigue; diarrhea; vomiting; abdominal pain; unexplained bleeding or bruising
Root Cause:
Systemic infection caused by the Ebola virus, leading to vascular damage, coagulopathy, and immune system dysregulation.
How it's Diagnosed: videos
PCR testing for Ebola RNA, enzyme-linked immunosorbent assay (ELISA), antigen detection tests, and clinical signs in endemic areas.
Treatment:
Supportive care including fluids, electrolyte management, oxygen therapy, and blood products; antivirals like Inmazeb (monoclonal antibody combination) may be used.
Medications:
Inmazeb (monoclonal antibody therapy), mAb114 (monoclonal antibody), and experimental antiviral drugs under trial during outbreaks.
Prevalence:
How common the health condition is within a specific population.
Outbreaks primarily in sub-Saharan Africa; rare outside endemic areas.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Contact with infected individuals, handling contaminated body fluids, exposure to bats or other reservoir species, and poor infection control practices.
Prognosis:
The expected outcome or course of the condition over time.
Mortality rates range from 25% to 90%, depending on the strain and access to medical care. Survivors often experience long-term complications.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Multiorgan failure, shock, disseminated intravascular coagulation (DIC), and long-term sequelae such as joint pain and vision problems.
Emergent Management of Pediatric Patients with Fever
Specialty: Infectious Diseases
Category: Pediatric Emergencies
Sub-category: Fever of Unknown Origin
Symptoms:
fever >38°c; irritability; lethargy; rash; vomiting; seizures (febrile); respiratory distress
Root Cause:
Fever in children may indicate an underlying infection, inflammatory condition, or other systemic issues requiring prompt evaluation.
How it's Diagnosed: videos
History and physical examination, blood tests (CBC, blood cultures), urinalysis, imaging studies (e.g., chest X-ray), lumbar puncture for meningitis suspicion.
Treatment:
Antipyretics, empiric antibiotics if bacterial infection is suspected, IV fluids for dehydration, and treatment of specific underlying conditions.
Medications:
Acetaminophen or ibuprofen for fever; empiric antibiotics such as ceftriaxone or ampicillin in suspected sepsis or meningitis; antiviral agents like acyclovir for herpes encephalitis .
Prevalence:
How common the health condition is within a specific population.
Fever is one of the most common presentations in pediatric emergencies worldwide.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Young age, incomplete vaccination status, recent illness or infection, and exposure to sick individuals.
Prognosis:
The expected outcome or course of the condition over time.
Good in most cases with timely diagnosis and treatment; prognosis depends on the underlying cause of the fever.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Febrile seizures, dehydration, sepsis, and delay in diagnosing life-threatening conditions.
Lymphocytic Choriomeningitis Virus (LCMV) Infection
Specialty: Infectious Diseases
Category: COVID-19 Reinfections
Symptoms:
fever; malaise; headache; nausea; vomiting; stiff neck; photophobia; confusion
Root Cause:
Infection caused by the LCMV, a rodent-borne arenavirus, leading to aseptic meningitis or meningoencephalitis in severe cases.
How it's Diagnosed: videos
Detection of LCMV-specific antibodies in cerebrospinal fluid (CSF) or blood, PCR for viral RNA, and history of exposure to rodents.
Treatment:
Supportive care, including pain management, anti-inflammatory medications, and fluid therapy; antivirals like ribavirin may be used experimentally.
Medications:
No FDA-approved specific treatment; ribavirin (antiviral) is sometimes used off-label for severe cases.
Prevalence:
How common the health condition is within a specific population.
Rare; exposure often occurs via infected rodents or their excreta, with occasional outbreaks in specific regions.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Exposure to rodents, handling pet hamsters, and living in environments with poor rodent control.
Prognosis:
The expected outcome or course of the condition over time.
Generally good with supportive care; severe cases can result in neurological complications or, rarely, death.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Neurological deficits, hydrocephalus, hearing loss, and miscarriage during pregnancy.
Norovirus
Specialty: Infectious Diseases
Category: COVID-19 Reinfections
Symptoms:
nausea; vomiting; diarrhea; abdominal cramps; fever; body aches; dehydration (in severe cases)
Root Cause:
Norovirus infection occurs when the virus infects the gastrointestinal tract, causing acute inflammation of the stomach and intestines. It is highly contagious and primarily spreads through contaminated food, water, surfaces, or direct contact.
How it's Diagnosed: videos
Diagnosis is usually clinical, based on symptoms and outbreak context. Laboratory testing (RT-PCR or enzyme immunoassay) can confirm norovirus presence in stool samples.
Treatment:
No specific antiviral treatment is available. Management focuses on supportive care, such as rehydration therapy (oral or IV) to replace lost fluids and electrolytes.
Medications:
There are no medications specifically targeting norovirus. Anti-nausea drugs like ondansetron (a serotonin 5-HT3 receptor antagonist) may be prescribed for severe vomiting. Oral rehydration salts (ORS) or electrolyte solutions help prevent dehydration.
Prevalence:
How common the health condition is within a specific population.
Norovirus causes approximately 685 million cases worldwide annually, with a significant impact on children under five years and older adults.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Close contact with infected individuals, consuming contaminated food or water, living in crowded environments (e.g., nursing homes, cruise ships), poor hand hygiene.
Prognosis:
The expected outcome or course of the condition over time.
Generally self-limiting; symptoms resolve within 1-3 days. Proper hydration ensures full recovery in most cases.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Severe dehydration, especially in young children, older adults, and immunocompromised individuals; rare cases of persistent gastrointestinal symptoms in vulnerable populations.
Reoviruses
Specialty: Infectious Diseases
Category: COVID-19 Reinfections
Symptoms:
fever; diarrhea; vomiting; respiratory symptoms; abdominal cramps
Root Cause:
Reoviruses, such as rotavirus, can cause gastrointestinal and respiratory infections, leading to dehydration and flu-like symptoms.
How it's Diagnosed: videos
Diagnosis is confirmed through stool samples (for rotavirus) or respiratory samples.
Treatment:
Treatment is supportive, focusing on hydration and managing symptoms like fever.
Medications:
Rehydration therapy (oral rehydration salts) and antipyretics (e.g., acetaminophen ).
Prevalence:
How common the health condition is within a specific population.
Reoviruses are common, particularly rotavirus, which affects infants and young children worldwide.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Poor sanitation, lack of vaccination, close contact with infected individuals.
Prognosis:
The expected outcome or course of the condition over time.
The infection is usually self-limiting, but severe dehydration can lead to complications if not treated.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Dehydration, electrolyte imbalances, and in severe cases, death, especially in young children.
Thogotoviruses/Bourbon Virus
Specialty: Infectious Diseases
Category: COVID-19 Reinfections
Symptoms:
fever; fatigue; muscle aches; headache; nausea; vomiting; rash
Root Cause:
Caused by the Bourbon virus, transmitted by ticks; results in systemic viral infection and immune response.
How it's Diagnosed: videos
Diagnosis is confirmed by PCR testing or serology to detect Bourbon virus antibodies.
Treatment:
Supportive care, including hydration, pain management, and fever control. No specific antiviral treatment.
Medications:
Acetaminophen (analgesic) and ibuprofen (anti-inflammatory) can be used to alleviate symptoms.
Prevalence:
How common the health condition is within a specific population.
Extremely rare, with only a handful of cases reported in the United States.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Tick exposure, rural areas, outdoor activities in tick-endemic regions.
Prognosis:
The expected outcome or course of the condition over time.
Generally mild to moderate disease; however, severe cases may lead to organ failure.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Organ failure, septic shock, death in severe cases.