Background

Comprehensive Symptom Navigator™

Your health assistant, simplified.

Disclaimer: This is just an assistant. It should not be used for diagnosing patients without a doctor's discretion.

Symptoms:

Number of Conditions: 130

Sinusitis

Specialty: Internal Medicine

Category: Respiratory Conditions

Symptoms:
facial pain or pressure; nasal congestion; runny nose; headache; fever; tooth pain; postnasal drip

Root Cause:
Inflammation or infection of the sinuses, often caused by a viral, bacterial, or fungal infection or allergies.

How it's Diagnosed: videos
Clinical examination, imaging (e.g., CT scan) if chronic or recurrent.

Treatment:
Symptomatic relief for viral cases (hydration, nasal irrigation, decongestants), antibiotics for bacterial infections, surgery for severe chronic cases.

Medications:
Nasal corticosteroids (e.g., fluticasone ), antibiotics (e.g., amoxicillin ) if bacterial, decongestants (e.g., pseudoephedrine ).

Prevalence: How common the health condition is within a specific population.
Common, with millions of cases annually; can be acute or chronic.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Allergies, smoking, nasal polyps, previous respiratory infections.

Prognosis: The expected outcome or course of the condition over time.
Usually resolves in a few weeks with appropriate treatment; chronic cases may require long-term management.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Chronic sinusitis, orbital cellulitis, brain abscess (rare).

Upper Respiratory Tract Infections (URTIs)

Specialty: Internal Medicine

Category: Infectious Diseases

Symptoms:
runny or stuffy nose; sore throat; cough; sneezing; mild fever; fatigue; headache

Root Cause:
Viral infections affecting the nasal passages, sinuses, pharynx, or larynx, commonly caused by rhinoviruses, coronaviruses, or adenoviruses.

How it's Diagnosed: videos
Clinical history and symptoms; no specific tests unless bacterial complications are suspected.

Treatment:
Supportive care (rest, hydration, symptomatic relief).

Medications:
OTC decongestants (e.g., pseudoephedrine ), pain relievers (e.g., ibuprofen , acetaminophen ), throat lozenges.

Prevalence: How common the health condition is within a specific population.
Very common; adults experience 2–4 episodes annually, while children have more frequent infections.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Close contact with infected individuals, colder seasons, weakened immune system.

Prognosis: The expected outcome or course of the condition over time.
Excellent; most cases resolve within 7–10 days.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Sinusitis, otitis media, secondary bacterial infections.

Mononucleosis (Glandular Fever)

Specialty: Internal Medicine

Category: Infectious Diseases

Symptoms:
fever; sore throat; swollen lymph nodes; fatigue; enlarged spleen; headache; muscle aches

Root Cause:
Infection by Epstein-Barr virus (EBV), spread through saliva ("kissing disease").

How it's Diagnosed: videos
Clinical symptoms, blood tests (monospot test, EBV antibodies).

Treatment:
Supportive care (hydration, rest, symptom relief); avoid physical activity to prevent spleen rupture.

Medications:
Pain relievers (e.g., acetaminophen , ibuprofen ) for fever and pain.

Prevalence: How common the health condition is within a specific population.
Common in adolescents and young adults; about 90% of adults are infected with EBV by adulthood.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Close contact with infected individuals, sharing drinks or utensils.

Prognosis: The expected outcome or course of the condition over time.
Excellent; symptoms resolve in 2–4 weeks, though fatigue may persist.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Spleen rupture, secondary infections, prolonged fatigue.

Chickenpox

Specialty: Pediatrics

Category: Infectious Diseases

Sub-category: Viral Exanthems

Symptoms:
itchy rash with fluid-filled blisters; fever; fatigue; loss of appetite; headache

Root Cause:
Infection with Varicella-zoster virus (VZV).

How it's Diagnosed: videos
Clinical diagnosis based on rash appearance; PCR testing or serologic testing in atypical cases.

Treatment:
Symptomatic relief (e.g., antihistamines, acetaminophen); antiviral therapy (e.g., acyclovir) in high-risk cases.

Medications:
Acyclovir (antiviral medication) may be prescribed for severe cases or immunocompromised patients. Antihistamines or calamine lotion may be used to manage itching.

Prevalence: How common the health condition is within a specific population.
Before widespread vaccination, almost universal in children; now much less common in vaccinated populations.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Lack of vaccination, exposure to infected individuals, immunosuppression.

Prognosis: The expected outcome or course of the condition over time.
Typically resolves without complications in healthy children; serious complications can occur in high-risk groups.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Secondary bacterial skin infections, pneumonia, encephalitis, or reactivation as shingles later in life.

Hydrocephalus

Specialty: Neurology

Category: Congenital and Genetic Disorders

Symptoms:
headache; nausea and vomiting; blurred or double vision; balance issues; cognitive impairments; irritability (in infants); bulging fontanel (in infants); sleepiness; seizures

Root Cause:
Accumulation of cerebrospinal fluid (CSF) in the brain's ventricles, causing increased intracranial pressure.

How it's Diagnosed: videos
Diagnosed using brain imaging (e.g., CT or MRI) to detect enlarged ventricles.

Treatment:
Treated with surgical placement of a ventriculoperitoneal (VP) shunt or endoscopic third ventriculostomy (ETV).

Medications:
Medications like acetazolamide or furosemide may be used temporarily to reduce CSF production; these are carbonic anhydrase inhibitors and diuretics, respectively.

Prevalence: How common the health condition is within a specific population.
Approximately 1-2 in 1,000 live births, with a higher prevalence in older adults with normal pressure hydrocephalus.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Congenital brain malformations, premature birth, brain infections, traumatic brain injury, intraventricular hemorrhage.

Prognosis: The expected outcome or course of the condition over time.
Variable; with timely treatment, many patients have good outcomes, but delays or complications can result in significant morbidity.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Infection or malfunction of the shunt, over-drainage of CSF, developmental delays, persistent neurological deficits.

Strep Throat

Specialty: Pediatrics

Category: Infectious Diseases

Sub-category: Common Pediatric Infections

Symptoms:
sore throat; painful swallowing; fever; swollen tonsils; white patches or streaks on the tonsils; swollen lymph nodes; headache; nausea or vomiting (in children)

Root Cause:
Bacterial infection caused by Streptococcus pyogenes (Group A Streptococcus).

How it's Diagnosed: videos
Rapid antigen detection test (RADT); throat culture for confirmation.

Treatment:
Antibiotic therapy to reduce symptoms and prevent complications, along with supportive care for symptom relief.

Medications:
Penicillin or amoxicillin (beta-lactam antibiotics) are the first-line treatments. In penicillin-allergic individuals, macrolides (e.g., azithromycin ) or cephalosporins may be prescribed.

Prevalence: How common the health condition is within a specific population.
Common in school-aged children; peaks during late fall and early spring.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Close contact with infected individuals, crowded environments (e.g., schools), young age (5–15 years).

Prognosis: The expected outcome or course of the condition over time.
Excellent with prompt treatment; symptoms typically resolve within 3–5 days.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Rheumatic fever, post-streptococcal glomerulonephritis, peritonsillar abscess, or scarlet fever.

Polio (Poliomyelitis)

Specialty: Pediatrics

Category: Infectious Diseases

Sub-category: Vaccination-Preventable Diseases

Symptoms:
fever; fatigue; headache; stiff neck; limb pain; paralysis in severe cases

Root Cause:
Caused by the poliovirus (a single-stranded RNA virus in the Picornaviridae family); spreads through fecal-oral transmission or respiratory droplets.

How it's Diagnosed: videos
Confirmed by detecting the virus in stool or throat samples using PCR, or serology for poliovirus-specific antibodies.

Treatment:
No cure; treatment focuses on supportive care, including physical therapy and assistive devices for paralysis.

Medications:
No antiviral drugs for polio; pain relief can include analgesics (e.g., acetaminophen or ibuprofen ).

Prevalence: How common the health condition is within a specific population.
Eradicated in many countries due to vaccination but still present in some regions (e.g., Afghanistan and Pakistan).

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Lack of vaccination, poor sanitation, and travel to areas with active transmission.

Prognosis: The expected outcome or course of the condition over time.
Good for non-paralytic cases, but paralysis can result in lifelong disability or death if respiratory muscles are affected.

Complications: Additional problems or conditions that may arise as a result of the original condition.
paralysis; post-polio syndrome (late complications); respiratory failure; death

Concussion and Traumatic Brain Injury (TBI)

Specialty: Emergency and Urgent Care

Category: Trauma and Injuries

Sub-category: Blunt Trauma

Symptoms:
headache; confusion; dizziness; nausea; vomiting; temporary loss of consciousness; difficulty concentrating; memory problems; sleep disturbances; mood changes

Root Cause:
Disruption in normal brain function due to a direct blow, jolt, or penetrating injury to the head causing mechanical damage to brain tissue.

How it's Diagnosed: videos
Clinical evaluation, Glasgow Coma Scale (GCS), neurological exam, imaging studies (CT scan or MRI).

Treatment:
Rest, symptom management, physical and cognitive rehabilitation, and monitoring for complications.

Medications:
Pain relievers (acetaminophen ), anti-nausea medications, and sometimes anticonvulsants (e.g., phenytoin ) or diuretics (e.g., mannitol ) to reduce intracranial pressure.

Prevalence: How common the health condition is within a specific population.
Millions of cases worldwide annually, with mild TBI (concussion) being the most common.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Sports injuries, motor vehicle accidents, falls, and assaults.

Prognosis: The expected outcome or course of the condition over time.
Most mild TBIs resolve with proper care; severe TBIs may result in lasting neurological deficits or disability.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Post-concussion syndrome, chronic traumatic encephalopathy (CTE), seizures, and long-term cognitive or psychological impairments.

Encephalitis

Specialty: Emergency and Urgent Care

Category: Neurological Emergencies

Sub-category: Infectious Neurological Conditions

Symptoms:
fever; headache; altered consciousness; seizures; confusion; weakness; speech difficulties

Root Cause:
Inflammation of brain parenchyma, often caused by viral infections (e.g., herpes simplex virus) or autoimmune processes.

How it's Diagnosed: videos
Clinical history, imaging (MRI), lumbar puncture (CSF analysis), EEG, and PCR testing for viral DNA/RNA.

Treatment:
Antiviral therapy, immunomodulatory therapy (if autoimmune), supportive care for seizures and intracranial pressure.

Medications:
Acyclovir (antiviral for herpes simplex encephalitis ), corticosteroids or intravenous immunoglobulin (IVIG) for autoimmune encephalitis .

Prevalence: How common the health condition is within a specific population.
5–10 cases per 100,000 annually worldwide.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Immunosuppression, travel to endemic areas, mosquito or tick bites, young or elderly age.

Prognosis: The expected outcome or course of the condition over time.
Variable; early treatment improves outcomes, but neurological sequelae may persist in severe cases.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Cognitive deficits, motor dysfunction, seizures, and death in severe cases.

Hyponatremia

Specialty: Nephrology

Category: Electrolyte and Acid-Base Disorders

Symptoms:
nausea; vomiting; confusion; headache; seizures; fatigue; restlessness; muscle weakness or spasms; coma in severe cases

Root Cause:
Low sodium concentration in the blood, often caused by excessive water retention, sodium loss, or a combination of both.

How it's Diagnosed: videos
Blood tests measuring serum sodium levels (<135 mEq/L), urine sodium and osmolality, and clinical evaluation of symptoms.

Treatment:
Treatment focuses on addressing the underlying cause, restricting fluid intake, or administering sodium supplementation. Severe cases may require hypertonic saline.

Medications:
Tolvaptan or conivaptan (vasopressin receptor antagonists), diuretics like loop diuretics (e.g., furosemide ) for certain cases, and sodium chloride for supplementation.

Prevalence: How common the health condition is within a specific population.
Common, particularly in hospitalized patients; estimated at 15–30% in such settings.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Heart failure, liver cirrhosis, kidney disease, SIADH, use of diuretics, excessive water intake, and advanced age.

Prognosis: The expected outcome or course of the condition over time.
Generally good if treated promptly, but severe hyponatremia can lead to permanent neurological damage or death if untreated.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Cerebral edema, seizures, coma, central pontine myelinolysis (from overly rapid correction).

Carbon Monoxide Poisoning

Specialty: Emergency and Urgent Care

Category: Toxicology and Overdose

Sub-category: Chemical Exposures

Symptoms:
headache; dizziness; nausea; shortness of breath; confusion; loss of consciousness; chest pain; seizures

Root Cause:
Carbon monoxide binds to hemoglobin with a higher affinity than oxygen, reducing oxygen delivery to tissues and causing hypoxia.

How it's Diagnosed: videos
Measurement of carboxyhemoglobin levels in blood using co-oximetry, pulse CO-oximeter, or arterial blood gas analysis. Symptoms and exposure history also aid diagnosis.

Treatment:
Immediate removal from the CO exposure source, 100% oxygen therapy through a non-rebreather mask, or hyperbaric oxygen therapy in severe cases.

Medications:
No direct medications, but 100% oxygen therapy and hyperbaric oxygen are the main treatments. Hyperbaric oxygen is classified as a high-pressure oxygen delivery treatment.

Prevalence: How common the health condition is within a specific population.
A leading cause of poisoning-related deaths worldwide, with an estimated 50,000 emergency department visits annually in the U.S.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Poorly ventilated spaces, faulty heating systems, exposure to fires, and use of charcoal or gas grills indoors.

Prognosis: The expected outcome or course of the condition over time.
Good with timely treatment; delayed or severe exposure may lead to long-term neurological complications.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Neurological sequelae (e.g., memory loss, difficulty concentrating), myocardial ischemia, arrhythmias, and death.

Cyanide Poisoning

Specialty: Emergency and Urgent Care

Category: Toxicology and Overdose

Sub-category: Chemical Exposures

Symptoms:
shortness of breath; confusion; headache; nausea; seizures; loss of consciousness; cardiac arrest

Root Cause:
Cyanide inhibits cytochrome oxidase in mitochondria, blocking cellular respiration and leading to rapid tissue hypoxia.

How it's Diagnosed: videos
Clinical suspicion based on exposure history, measurement of cyanide levels in blood, arterial blood gas showing metabolic acidosis with high lactate.

Treatment:
Administration of specific antidotes (e.g., hydroxocobalamin, sodium thiosulfate) and supportive care, including oxygen therapy and mechanical ventilation if needed.

Medications:
Hydroxocobalamin (binds cyanide to form cyanocobalamin , excreted in urine), Sodium thiosulfate (enhances cyanide metabolism to thiocyanate), and Nitrites (to induce methemoglobin formation, binding cyanide). These are classified as antidotes.

Prevalence: How common the health condition is within a specific population.
Rare in the general population but associated with industrial exposures, smoke inhalation from fires, and deliberate ingestion.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Exposure to industrial chemicals, smoke inhalation from fires, ingestion of cyanogenic compounds (e.g., amygdalin in apricot seeds).

Prognosis: The expected outcome or course of the condition over time.
Excellent with early and appropriate treatment; poor prognosis in delayed or severe cases without intervention.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Hypoxic brain injury, multi-organ failure, and death.

Preeclampsia and Eclampsia

Specialty: Nephrology

Category: Other Renal-Associated Conditions

Sub-category: Pregnancy-Related Kidney Conditions

Symptoms:
high blood pressure; proteinuria; swelling in hands and face; headache; visual disturbances; upper abdominal pain; nausea or vomiting; shortness of breath; seizures in eclampsia

Root Cause:
Abnormal placental development leading to systemic endothelial dysfunction, causing hypertension, proteinuria, and other organ damage.

How it's Diagnosed: videos
Blood pressure measurement (greater than or equal to 140/90 mmHg), urine tests for proteinuria, blood tests for liver function, kidney function, and platelet count, and fetal ultrasound for growth assessment.

Treatment:
Blood pressure management, magnesium sulfate to prevent seizures, corticosteroids to accelerate fetal lung maturity if delivery is anticipated, and delivery of the baby as the definitive treatment.

Medications:
Antihypertensives such as labetalol (beta-blocker), hydralazine (vasodilator), or nifedipine (calcium channel blocker); magnesium sulfate (anticonvulsant) for seizure prevention.

Prevalence: How common the health condition is within a specific population.
Affects 2-8% of pregnancies globally, more common in first-time pregnancies.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
First pregnancy, history of preeclampsia, multiple pregnancies (twins or more), obesity, pre-existing hypertension or diabetes, maternal age <20 or >35, and certain genetic factors.

Prognosis: The expected outcome or course of the condition over time.
With timely treatment, outcomes are generally good; however, severe cases can lead to long-term health issues for both mother and baby.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Eclampsia (seizures), HELLP syndrome, liver or kidney failure, placental abruption, preterm delivery, maternal or fetal death.

Heatstroke

Specialty: Senior Health and Geriatrics

Category: Miscellaneous Age-Related Conditions

Sub-category: Thermoregulatory Disorders

Symptoms:
high body temperature (above 104°f or 40°c); altered mental state (confusion, agitation, delirium); hot, dry skin; rapid heartbeat; shallow breathing; nausea or vomiting; headache; muscle cramps

Root Cause:
The body’s thermoregulation system becomes overwhelmed in extremely hot environments, causing a dangerous increase in body temperature. In older adults, the ability to regulate body temperature may be impaired due to decreased sweating, dehydration, or underlying medical conditions.

How it's Diagnosed: videos
Diagnosis is typically clinical, based on symptoms such as elevated body temperature and altered mental status. Laboratory tests (blood tests, urinalysis) may help assess the severity of organ dysfunction, dehydration, and electrolyte imbalances.

Treatment:
The primary treatment for heatstroke involves immediate cooling of the body, such as immersing the person in cool water, applying ice packs to areas like the neck, armpits, and groin, and using cooling blankets. Intravenous fluids are given to rehydrate the person and correct electrolyte imbalances. In severe cases, hospitalization is necessary for organ support.

Medications:
No specific medications are typically used to treat heatstroke, but medications such as intravenous fluids (saline or Ringer's lactate) are used to correct dehydration and electrolyte imbalances. Antipyretics like acetaminophen or ibuprofen are not recommended because they may mask symptoms and interfere with body cooling. In cases of seizures, anticonvulsant medications (e.g., lorazepam ) may be given.

Prevalence: How common the health condition is within a specific population.
Heatstroke is more common in older adults, especially during heatwaves, as their ability to regulate body temperature decreases with age. It can be fatal without prompt treatment.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Advanced age, dehydration, chronic medical conditions (e.g., heart disease, diabetes), use of certain medications (e.g., diuretics, anticholinergics), and exposure to high temperatures, especially in humid environments.

Prognosis: The expected outcome or course of the condition over time.
Heatstroke is a medical emergency, and prognosis depends on the speed of intervention. With immediate treatment, recovery is possible, but the risk of long-term organ damage or death increases with delayed treatment.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Organ failure (especially kidney and liver), heat-related brain damage, seizures, shock, and death are possible in severe cases if treatment is not initiated quickly.

Giant Cell Arteritis (Temporal Arteritis)

Specialty: Cardiovascular

Category: Vascular Diseases

Sub-category: Vasculitis

Symptoms:
headache; jaw claudication (pain while chewing); scalp tenderness; vision loss; fever; fatigue; weight loss

Root Cause:
Inflammation of large- and medium-sized arteries, especially the temporal arteries, due to an immune-mediated process.

How it's Diagnosed: videos
Clinical symptoms; elevated ESR and CRP; temporal artery biopsy (showing granulomatous inflammation); Doppler ultrasound of the temporal artery

Treatment:
High-dose corticosteroids to reduce inflammation and prevent complications, followed by a gradual tapering.

Medications:
Corticosteroids such as prednisone (anti-inflammatory), tocilizumab (an IL-6 receptor antagonist for refractory cases), and aspirin (antiplatelet therapy to reduce vascular complications).

Prevalence: How common the health condition is within a specific population.
Affects approximately 200 per 100,000 people aged over 50; more common in women and people of Northern European descent.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Age >50 years; female sex; genetic predisposition (HLA-DR4); Northern European ancestry

Prognosis: The expected outcome or course of the condition over time.
Good with early treatment; untreated cases risk permanent vision loss or aortic aneurysm.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Permanent vision loss; aortic aneurysm; stroke; vascular stenosis

Mal de Debarquement Syndrome (MdDS)

Specialty: Ear

Category: Balance and Vestibular Disorders

Sub-category: Motion Sensitivity Disorders

Symptoms:
persistent sensation of rocking, swaying, or bobbing (often described as feeling ‘like being on a boat’); fatigue; difficulty concentrating (‘brain fog’); headache; dizziness; anxiety or depression (as a result of the chronic symptoms)

Root Cause:
MdDS is believed to occur due to the brain's inability to readjust its perception of movement and balance after prolonged exposure to passive motion, such as on a boat, airplane, or train. The exact neurological mechanism is not well understood.

How it's Diagnosed: videos
Diagnosed clinically by a sensation of rocking after travel.

Treatment:
Vestibular rehabilitation therapy, motion desensitization techniques, cognitive-behavioral therapy, and in some cases, medications.

Medications:
Medications may help alleviate symptoms. Commonly prescribed drugs include benzodiazepines or antidepressants to manage symptoms.

Prevalence: How common the health condition is within a specific population.
Exact prevalence is unknown but considered rare. More common among middle-aged women and individuals after prolonged motion exposure.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Female gender (particularly middle-aged women). Prolonged exposure to passive motion (e.g., cruises, long flights, car rides). History of motion sensitivity or migraines.

Prognosis: The expected outcome or course of the condition over time.
Symptoms often resolve within weeks to months but can persist for years in some cases. Prognosis is variable and depends on individual response to treatments.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Chronic fatigue and impaired quality of life. Anxiety and depression due to persistent symptoms. Potential difficulties with employment or daily functioning.

Mastoiditis

Specialty: Ear

Category: Infectious and Inflammatory Ear Conditions

Sub-category: Other Inflammatory Conditions

Symptoms:
ear pain; swelling behind the ear; fever; hearing loss; ear discharge; redness and tenderness behind the ear; headache; irritability in children

Root Cause:
Bacterial infection of the mastoid air cells in the temporal bone, often due to untreated or poorly managed otitis media (middle ear infection).

How it's Diagnosed: videos
Clinical examination (checking for swelling and redness behind the ear), imaging studies (CT scan of the temporal bone), and blood tests (to check for infection).

Treatment:
Intravenous antibiotics, drainage of abscess if present, and mastoidectomy in severe or refractory cases.

Medications:
Antibiotics such as ceftriaxone (a third-generation cephalosporin) or vancomycin (a glycopeptide antibiotic) may be prescribed. Antibiotic choice depends on culture results and bacterial resistance patterns.

Prevalence: How common the health condition is within a specific population.
Rare in developed countries due to effective treatment of otitis media; more common in regions with limited access to healthcare.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Untreated or recurrent otitis media, immunosuppression, poor access to healthcare, and chronic ear infections.

Prognosis: The expected outcome or course of the condition over time.
Good with prompt treatment; complications are rare if treated early. Delay in treatment can lead to life-threatening complications.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Brain abscess, meningitis, hearing loss, venous sinus thrombosis, and facial nerve paralysis.

Bacterial Sinusitis

Specialty: Nose and Throat

Category: Nasal Conditions

Sub-category: Infectious and Inflammatory Conditions

Symptoms:
facial pain or pressure; nasal congestion; green or yellow nasal discharge; reduced sense of smell; fever; tooth pain; headache; fatigue

Root Cause:
Inflammation and infection of the sinuses caused by bacterial pathogens (e.g., Streptococcus pneumoniae, Haemophilus influenzae). The infection usually follows a viral upper respiratory infection.

How it's Diagnosed: videos
Diagnosis is based on clinical history and symptoms. A nasal endoscopy or CT scan may be performed for recurrent or severe cases to confirm the diagnosis and rule out complications.

Treatment:
Treatment typically includes a 10-14 day course of antibiotics (e.g., amoxicillin, doxycycline). Decongestants, nasal corticosteroids, and saline irrigation may help alleviate symptoms.

Medications:
Antibiotics like amoxicillin (penicillin class) and doxycycline (tetracycline class) are used to treat the bacterial infection. Nasal corticosteroids (e.g., fluticasone , budesonide ) help reduce inflammation.

Prevalence: How common the health condition is within a specific population.
Affects about 10% of adults annually, with an increased incidence during the colder months.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Prior upper respiratory infections, allergies, nasal polyps, asthma, smoking, and anatomical nasal obstructions.

Prognosis: The expected outcome or course of the condition over time.
With appropriate treatment, bacterial sinusitis often resolves within a few weeks. Chronic or recurrent cases may require longer treatment or surgery.

Complications: Additional problems or conditions that may arise as a result of the original condition.
If untreated, it may lead to abscesses, meningitis, or chronic sinus problems.

Viral Sinusitis

Specialty: Nose and Throat

Category: Nasal Conditions

Sub-category: Infectious and Inflammatory Conditions

Symptoms:
nasal congestion; clear nasal discharge; sneezing; headache; mild facial pain or pressure; cough; sore throat

Root Cause:
Inflammation of the sinuses due to a viral infection, often following a cold or upper respiratory viral infection (e.g., rhinovirus, influenza).

How it's Diagnosed: videos
Diagnosis is typically clinical, with a history of a viral upper respiratory infection. Nasal cultures are generally not required unless there is a concern for bacterial superinfection.

Treatment:
Symptomatic treatment includes decongestants, nasal saline irrigation, and pain relievers (e.g., acetaminophen). Antibiotics are not used unless bacterial infection is suspected.

Medications:
Symptomatic relief can be achieved with decongestants (e.g., pseudoephedrine ) and pain relievers (e.g., acetaminophen ). Nasal saline irrigation may also be used.

Prevalence: How common the health condition is within a specific population.
Viral sinusitis is common, with most individuals experiencing it at least once in their lifetime, especially during cold and flu season.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Upper respiratory viral infections, smoking, allergies, and anatomical nasal blockages.

Prognosis: The expected outcome or course of the condition over time.
Generally resolves on its own within 7-10 days; however, symptoms can linger. Complications are rare unless bacterial sinusitis develops.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Can lead to bacterial superinfection, chronic sinusitis, or ear infections.

Fungal Sinusitis

Specialty: Infectious Diseases

Category: Fungal Infections

Symptoms:
nasal congestion; facial pain or pressure; nasal discharge (often thick and discolored); loss of smell; headache; fever (in severe cases)

Root Cause:
Fungal growth in the sinuses due to compromised immune function or environmental exposure.

How it's Diagnosed: videos
Nasal endoscopy, imaging studies (CT or MRI), and fungal culture or biopsy.

Treatment:
Surgical debridement of affected tissue, antifungal medications, and management of underlying conditions.

Medications:
Antifungal medications such as amphotericin B (polyene antifungal) or itraconazole (triazole antifungal).

Prevalence: How common the health condition is within a specific population.
Rare; higher prevalence in immunocompromised individuals or those with uncontrolled diabetes.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Immunosuppression, diabetes, use of corticosteroids, chronic sinusitis, environmental exposure to fungal spores.

Prognosis: The expected outcome or course of the condition over time.
Good with early diagnosis and treatment, but delays can lead to severe complications.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Orbital cellulitis, cavernous sinus thrombosis, intracranial abscess, and systemic fungal spread.

Pharyngitis (Viral - e.g., Adenovirus, EBV)

Specialty: Nose and Throat

Category: Throat (Pharyngeal and Laryngeal) Conditions

Sub-category: Infectious and Inflammatory Conditions

Symptoms:
sore throat; fever; fatigue; swollen lymph nodes; headache; cough

Root Cause:
Viral infections, such as adenovirus and Epstein-Barr virus (EBV), cause inflammation of the pharynx.

How it's Diagnosed: videos
Diagnosis is based on clinical symptoms and rapid tests for common viral infections (e.g., rapid strep test can help rule out bacterial causes). Throat swabs and blood tests may be used to confirm EBV.

Treatment:
Supportive care such as rest, hydration, pain relievers (e.g., acetaminophen, ibuprofen), and throat lozenges. EBV infection may require antiviral medications in severe cases.

Medications:
Over-the-counter analgesics (e.g., acetaminophen , ibuprofen ) for pain relief. In severe cases of EBV, antiviral drugs like acyclovir may be prescribed, though they are rarely used unless complications arise.

Prevalence: How common the health condition is within a specific population.
Common, especially in children and young adults. EBV is the cause of infectious mononucleosis, which affects approximately 1 in 4 young adults.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Close contact with infected individuals, weakened immune system, age (most common in children and young adults).

Prognosis: The expected outcome or course of the condition over time.
Generally good; viral pharyngitis resolves within a week or two. EBV-related mononucleosis can last longer but usually improves with supportive care.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Rare but can include secondary bacterial infections, such as a streptococcal infection, and complications from EBV, such as splenomegaly or hepatitis.

Pharyngitis (Bacterial - e.g., Streptococcal Pharyngitis)

Specialty: Nose and Throat

Category: Throat (Pharyngeal and Laryngeal) Conditions

Sub-category: Infectious and Inflammatory Conditions

Symptoms:
sore throat; fever; red and swollen tonsils; white patches on the tonsils; painful swallowing; headache

Root Cause:
Bacterial infection caused by Group A Streptococcus (GAS), leading to inflammation of the throat.

How it's Diagnosed: videos
Throat culture or rapid antigen test to identify the presence of Streptococcus bacteria.

Treatment:
Antibiotics (usually penicillin or amoxicillin) to treat the bacterial infection and prevent complications.

Medications:
Antibiotics such as penicillin, amoxicillin , or cephalosporins. Pain relievers like acetaminophen or ibuprofen may also be prescribed.

Prevalence: How common the health condition is within a specific population.
Streptococcal pharyngitis is most common in children, especially between the ages of 5-15. It is more common in the winter and early spring months.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Close contact with infected individuals, being in crowded environments (e.g., schools), age (children more susceptible), weakened immune system.

Prognosis: The expected outcome or course of the condition over time.
Excellent with prompt antibiotic treatment. If untreated, it can lead to complications like rheumatic fever or kidney problems.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Rheumatic fever, scarlet fever, glomerulonephritis, or peritonsillar abscess.

Coccidioidomycosis (Valley Fever)

Specialty: Pulmonology

Category: Infectious Diseases of the Respiratory System

Sub-category: Fungal Infections

Symptoms:
fever; cough; fatigue; chest pain; shortness of breath; rash; headache; joint pain

Root Cause:
Caused by inhaling spores of Coccidioides species, fungi found in desert soils in the southwestern United States and parts of Mexico and Central and South America.

How it's Diagnosed: videos
Blood tests for antibodies, antigen detection, fungal cultures, imaging (chest X-ray or CT scan), or biopsy of affected tissues.

Treatment:
Mild cases often resolve without treatment; antifungal therapy is required for severe or chronic cases.

Medications:
Fluconazole or itraconazole (triazole antifungals) for most cases; amphotericin B (a polyene antifungal) for severe or disseminated infections.

Prevalence: How common the health condition is within a specific population.
Endemic to arid regions; affects tens of thousands annually in the U.S., particularly in Arizona and California.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Living in or traveling to endemic areas, occupational exposure to dust, pregnancy, and immune suppression.

Prognosis: The expected outcome or course of the condition over time.
Good for acute cases; chronic or disseminated infections may require long-term treatment and carry a risk of complications.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Chronic pulmonary disease, disseminated infection affecting bones, skin, or meninges, and severe respiratory distress.

Influenza

Specialty: Infectious Diseases

Category: COVID-19 Reinfections

Symptoms:
fever; chills; headache; muscle aches; fatigue; sore throat; cough; runny nose

Root Cause:
Influenza is a viral infection that primarily affects the respiratory system. The virus causes inflammation of the airways, leading to systemic symptoms.

How it's Diagnosed: videos
Diagnosis is typically clinical, but can be confirmed with rapid antigen tests or PCR.

Treatment:
Antiviral medications such as oseltamivir or zanamivir can reduce symptom duration if taken early. Supportive care includes hydration, rest, and fever management.

Medications:
Oseltamivir (Tamiflu ) and zanamivir (Relenza ) are neuraminidase inhibitors used to treat influenza . These medications shorten the duration of illness if started within 48 hours of symptom onset.

Prevalence: How common the health condition is within a specific population.
Influenza affects millions worldwide each year, with seasonal outbreaks occurring mostly during fall and winter.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Young children, elderly adults, pregnant women, and individuals with chronic health conditions (e.g., asthma, diabetes) are at higher risk.

Prognosis: The expected outcome or course of the condition over time.
Most individuals recover within 1-2 weeks, but complications can occur, especially in high-risk populations.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Can lead to pneumonia, bronchitis, sinus infections, and worsening of underlying chronic diseases.

COVID-19

Specialty: Pulmonology

Category: Infectious Diseases of the Respiratory System

Sub-category: Viral Infections

Symptoms:
fever; dry cough; shortness of breath; fatigue; loss of taste or smell; sore throat; muscle aches; headache; chills; nausea or vomiting; diarrhea

Root Cause:
Caused by SARS-CoV-2, a novel coronavirus. Transmitted through respiratory droplets, aerosols, and contaminated surfaces.

How it's Diagnosed: videos
PCR testing, rapid antigen tests, and clinical evaluation of symptoms.

Treatment:
Supportive care, antiviral drugs, corticosteroids, and oxygen therapy in severe cases.

Medications:
Antiviral drugs such as remdesivir (RNA polymerase inhibitor) and paxlovid (combination of nirmatrelvir and ritonavir ) may be used. Severe cases may require corticosteroids like dexamethasone or monoclonal antibodies for immunomodulation.

Prevalence: How common the health condition is within a specific population.
Affects populations globally; widespread outbreaks occurred in 2020-2021 with continued endemic cases.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Advanced age, obesity, chronic medical conditions (e.g., diabetes, cardiovascular disease, COPD), immunosuppression.

Prognosis: The expected outcome or course of the condition over time.
Highly variable; mild cases recover in 1-2 weeks, while severe cases can lead to long-term complications or death.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Pneumonia, acute respiratory distress syndrome (ARDS), blood clots, multi-organ failure, "long COVID" (persistent symptoms).

Severe Acute Respiratory Syndrome (SARS)

Specialty: Infectious Diseases

Category: Lower Respiratory Tract Infections

Symptoms:
high fever; dry cough; shortness of breath; muscle pain; headache; chills; diarrhea; fatigue

Root Cause:
Viral infection caused by the SARS-CoV coronavirus, primarily transmitted through respiratory droplets or close contact. Severe cases involve acute respiratory distress syndrome (ARDS).

How it's Diagnosed: videos
Diagnosis involves PCR testing for SARS-CoV, chest imaging showing pneumonia or ARDS, and serologic tests for antibodies.

Treatment:
Supportive care, including oxygen therapy, mechanical ventilation in severe cases, and management of secondary infections. No specific antiviral treatment is universally accepted.

Medications:
Experimental - Ribavirin , corticosteroids, and interferons were used during the 2003 outbreak but with limited efficacy. Supportive medications - Antipyretics for fever, analgesics for pain, and bronchodilators for respiratory relief.

Prevalence: How common the health condition is within a specific population.
Emerged in 2002–2003 with approximately 8,000 cases globally and a mortality rate of about 9.6%.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Close contact with infected individuals, healthcare workers exposed to infected patients, and travelers to outbreak areas.

Prognosis: The expected outcome or course of the condition over time.
Early supportive care improves outcomes. Severe cases may lead to high mortality, especially in older adults or those with comorbidities.

Complications: Additional problems or conditions that may arise as a result of the original condition.
ARDS, septic shock, organ failure, and long-term pulmonary dysfunction in survivors.

Hypercapnic Respiratory Failure

Specialty: Pulmonology

Category: Respiratory Failure and Critical Care

Symptoms:
shortness of breath; confusion; headache; drowsiness; flushed skin; rapid breathing

Root Cause:
Hypercapnic respiratory failure occurs when the lungs are unable to remove enough carbon dioxide from the blood, often due to obstructive lung diseases such as COPD or severe asthma.

How it's Diagnosed: videos
Diagnosis is confirmed through ABG analysis showing elevated levels of carbon dioxide (PaCO2 > 45 mmHg), along with clinical symptoms of hypoventilation.

Treatment:
Management includes non-invasive positive pressure ventilation (NIPPV) or invasive mechanical ventilation, bronchodilators, corticosteroids, and addressing the underlying cause (e.g., COPD exacerbation).

Medications:
Bronchodilators (e.g., albuterol , ipratropium ) to open the airways, corticosteroids (e.g., methylprednisolone ), and respiratory stimulants (e.g., theophylline ) are commonly used. These medications are classified as bronchodilators, corticosteroids, and respiratory stimulants.

Prevalence: How common the health condition is within a specific population.
Common among patients with chronic obstructive pulmonary disease (COPD), emphysema, and severe asthma.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Chronic obstructive pulmonary disease (COPD), obesity, neuromuscular disorders, severe asthma, and drug overdose.

Prognosis: The expected outcome or course of the condition over time.
Prognosis depends on the underlying condition; with appropriate treatment, many patients can recover, although severe cases may have poor outcomes.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Respiratory acidosis, pulmonary hypertension, organ failure, and long-term respiratory impairment.

Arteriovenous Malformations (AVMs)

Specialty: Neurology

Category: Cerebrovascular Diseases

Symptoms:
headache; seizures; progressive neurological deficits; weakness or numbness; vision problems; dizziness

Root Cause:
Abnormal tangling of arteries and veins, bypassing capillaries, leading to weakened vessels prone to rupture.

How it's Diagnosed: videos
CT or MRI of the brain; cerebral angiography to confirm and map the AVM.

Treatment:
Surgical removal, endovascular embolization, or stereotactic radiosurgery, depending on size and location.

Medications:
Antiepileptics for seizure control; pain medications for symptom relief.

Prevalence: How common the health condition is within a specific population.
Rare; affects less than 1% of the population.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Congenital malformation; rarely familial.

Prognosis: The expected outcome or course of the condition over time.
Good if treated before rupture; untreated AVMs carry a 2-4% annual risk of hemorrhage.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Intracranial hemorrhage, permanent neurological damage, and seizures.

Cavernous Malformations

Specialty: Neurology

Category: Cerebrovascular Diseases

Symptoms:
seizures; progressive neurological deficits; headache; vision changes; difficulty speaking

Root Cause:
Cluster of abnormal, thin-walled blood vessels prone to leaking but less likely to cause massive hemorrhage.

How it's Diagnosed: videos
MRI with gradient-echo sequences for detection.

Treatment:
Monitoring for asymptomatic cases; surgical removal for symptomatic or accessible lesions.

Medications:
Antiepileptics for seizure control.

Prevalence: How common the health condition is within a specific population.
Affects 0.1-0.5% of the population; some cases are familial.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Genetic mutations, particularly in familial cases.

Prognosis: The expected outcome or course of the condition over time.
Variable; good with appropriate treatment.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Progressive neurological deficits, recurrent hemorrhage, and seizures.

Moyamoya Disease

Specialty: Neurology

Category: Cerebrovascular Diseases

Symptoms:
recurrent strokes or tias; headache; seizures; cognitive impairment; progressive weakness or numbness; speech difficulties

Root Cause:
Progressive narrowing of cerebral arteries, especially the internal carotid arteries, leading to the formation of collateral vessels (moyamoya vessels) that are fragile and prone to rupture or insufficient blood flow.

How it's Diagnosed: videos
MRI and MR angiography, CT angiography, cerebral angiography, and perfusion studies.

Treatment:
Surgical revascularization techniques such as direct bypass (e.g., STA-MCA bypass) or indirect bypass (e.g., encephaloduroarteriosynangiosis).

Medications:
Antiplatelet agents like aspirin to reduce stroke risk; anticonvulsants for seizure control.

Prevalence: How common the health condition is within a specific population.
Rare; higher prevalence in East Asian populations, particularly Japan and Korea.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Genetic predisposition, particularly in familial cases; associated with conditions like Down syndrome and neurofibromatosis type 1.

Prognosis: The expected outcome or course of the condition over time.
Good with surgical intervention; progressive without treatment, with a high risk of recurrent strokes.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Recurrent strokes, hemorrhages, cognitive decline, and seizure disorders.

Acute Disseminated Encephalomyelitis (ADEM)

Specialty: Infectious Diseases

Category: CNS Infections

Symptoms:
fever; headache; nausea; vomiting; confusion; seizures; motor weakness; vision problems; lethargy

Root Cause:
An autoimmune response often triggered by an infection or, less commonly, vaccination, causing inflammation and demyelination in the brain and spinal cord.

How it's Diagnosed: videos
Clinical evaluation, MRI of the brain (showing diffuse demyelination), lumbar puncture (to analyze cerebrospinal fluid), and exclusion of other conditions like multiple sclerosis.

Treatment:
High-dose corticosteroids (e.g., methylprednisolone), plasma exchange (plasmapheresis), intravenous immunoglobulin (IVIG), and supportive care.

Medications:
Corticosteroids (e.g., methylprednisolone for reducing inflammation), IVIG (immunomodulatory therapy), or plasmapheresis (used when steroids are insufficient). Corticosteroids are classified as anti-inflammatory agents.

Prevalence: How common the health condition is within a specific population.
Rare; estimated annual incidence is 0.4-0.8 per 100,000 people, more common in children than adults.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Recent viral or bacterial infections, recent vaccination, genetic predisposition, or underlying autoimmune disorders.

Prognosis: The expected outcome or course of the condition over time.
Good in most cases; symptoms often resolve with treatment, although some individuals may experience residual neurological deficits.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Long-term neurological impairment, recurrence (though rare), or progression to conditions like multiple sclerosis in some cases.

Meningitis (Bacterial, Viral, Fungal)

Specialty: Neurology

Category: Infections and Inflammatory Diseases

Symptoms:
fever; headache; neck stiffness; nausea; vomiting; sensitivity to light (photophobia); altered mental status; seizures

Root Cause:
Inflammation of the meninges, typically caused by bacterial, viral, or fungal infections.

How it's Diagnosed: videos
Lumbar puncture to analyze cerebrospinal fluid (CSF); blood cultures; imaging (CT/MRI) for complications or suspected mass lesions; PCR for viral causes.

Treatment:
Treatment depends on the cause. Bacterial meningitis requires prompt antibiotic therapy, while viral meningitis may resolve on its own or require supportive care. Fungal meningitis is treated with antifungals.

Medications:
For bacterial meningitis - Empiric antibiotics such as ceftriaxone and vancomycin , with targeted therapy after pathogen identification. Corticosteroids (e.g., dexamethasone ) may reduce inflammation. For viral meningitis - Antiviral drugs like acyclovir for herpes simplex virus. For fungal meningitis - Amphotericin B and flucytosine for Cryptococcus species.

Prevalence: How common the health condition is within a specific population.
Varies globally; bacterial meningitis is more common in low-income regions, while viral meningitis is more frequent in developed countries.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Close contact with infected individuals, weakened immune system, head injury, neurosurgical procedures, certain geographic areas (e.g., meningitis belt in Sub-Saharan Africa).

Prognosis: The expected outcome or course of the condition over time.
Bacterial meningitis can be life-threatening if untreated but has good outcomes with prompt treatment. Viral meningitis usually resolves without long-term effects. Fungal meningitis has a more guarded prognosis, especially in immunocompromised patients.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Brain damage, hearing loss, seizures, hydrocephalus, septic shock, death (especially in untreated bacterial cases).

Encephalitis (e.g., Herpes Simplex Encephalitis)

Specialty: Neurology

Category: Infections and Inflammatory Diseases

Symptoms:
fever; headache; altered mental status; seizures; focal neurological deficits; confusion; memory loss; personality changes

Root Cause:
Inflammation of the brain, often caused by viral infections (e.g., herpes simplex virus, arboviruses) or autoimmune mechanisms.

How it's Diagnosed: videos
MRI to detect brain inflammation; lumbar puncture for CSF analysis and PCR for viral DNA (e.g., HSV); EEG to evaluate for seizures; blood tests for autoimmune markers if suspected.

Treatment:
Depends on cause. Antiviral therapy for HSV (e.g., acyclovir), supportive care for arboviruses, and immunosuppressive treatment (e.g., corticosteroids, IVIG) for autoimmune causes.

Medications:
For HSV encephalitis - Acyclovir (antiviral agent). For autoimmune encephalitis - Corticosteroids, IVIG, plasmapheresis, or rituximab (a monoclonal antibody).

Prevalence: How common the health condition is within a specific population.
Herpes simplex encephalitis occurs in approximately 1 in 250,000 to 500,000 people annually. Prevalence varies for other causes.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Immunocompromised state, travel to areas with endemic arboviruses, exposure to infected individuals, autoimmune diseases.

Prognosis: The expected outcome or course of the condition over time.
Early treatment (especially for HSV) significantly improves outcomes. Delayed treatment can lead to permanent neurological damage or death.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Long-term neurological deficits (e.g., memory impairment, seizures, cognitive dysfunction), coma, death (if untreated).

Brain Abscess

Specialty: Infectious Diseases

Category: CNS Infections

Symptoms:
headache; fever; nausea; vomiting; neurological deficits; seizures; altered mental status

Root Cause:
Focal collection of pus in the brain tissue, often caused by bacterial or fungal infections entering through the bloodstream, contiguous spread, or trauma.

How it's Diagnosed: videos
MRI or CT scan with contrast, blood cultures, and biopsy of the abscess for microbiological testing.

Treatment:
Surgical drainage or aspiration, combined with broad-spectrum antibiotics tailored based on culture results.

Medications:
Antibiotics such as ceftriaxone (a cephalosporin) or metronidazole (an anti-anaerobic agent). For fungal infections, amphotericin B or fluconazole may be used.

Prevalence: How common the health condition is within a specific population.
Rare, with an estimated incidence of 0.3 to 1.3 cases per 100,000 people annually.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Immunocompromised status (HIV, organ transplantation), chronic sinusitis, otitis media, congenital heart defects, head trauma.

Prognosis: The expected outcome or course of the condition over time.
With prompt treatment, mortality rates are around 10–20%, but neurological deficits may persist.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Increased intracranial pressure, brain herniation, seizures, recurrence of infection, or neurological impairments.

Neurocysticercosis

Specialty: Infectious Diseases

Category: CNS Infections

Sub-category: Parasitic Infections

Symptoms:
seizures; headache; nausea; vomiting; vision problems; hydrocephalus; altered mental status

Root Cause:
Infection of the central nervous system by Taenia solium larvae (pork tapeworm), leading to cyst formation in the brain.

How it's Diagnosed: videos
Neuroimaging (MRI or CT) revealing cysts or calcifications, serologic tests for T. solium antibodies, and CSF analysis.

Treatment:
Antiparasitic therapy with albendazole or praziquantel, corticosteroids to reduce inflammation, anticonvulsants for seizure management, and surgical intervention in severe cases.

Medications:
Albendazole (antiparasitic), praziquantel (antiparasitic), dexamethasone (corticosteroid), and levetiracetam or phenytoin (anticonvulsants).

Prevalence: How common the health condition is within a specific population.
Leading cause of acquired epilepsy in developing countries; affects millions globally, particularly in regions with poor sanitation.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Consumption of undercooked pork, poor sanitation, close contact with infected individuals, and living in endemic areas.

Prognosis: The expected outcome or course of the condition over time.
Favorable with treatment in uncomplicated cases; long-term anticonvulsant therapy may be required for seizure control.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Chronic epilepsy, hydrocephalus, intracranial hypertension, and neurological deficits.

Concussion

Specialty: Neurology

Category: Traumatic Brain and Spinal Cord Injuries

Symptoms:
headache; confusion; dizziness; nausea; vomiting; blurred vision; sensitivity to light and noise; memory loss; difficulty concentrating; fatigue

Root Cause:
A mild traumatic brain injury caused by a sudden impact or jolt to the head, leading to temporary disruption of brain function.

How it's Diagnosed: videos
Clinical evaluation (patient history, symptom analysis, and physical examination), neurocognitive testing, imaging tests like CT or MRI (if severe symptoms or risk of complications).

Treatment:
Rest, gradual return to activities, symptom management, cognitive and physical rehabilitation if needed.

Medications:
Pain relievers like acetaminophen or ibuprofen for headaches. Prescription medications, such as amitriptyline (tricyclic antidepressant) or topiramate (antiepileptic), may be used for post-concussion headaches or migraines.

Prevalence: How common the health condition is within a specific population.
Common; estimated 1.6–3.8 million concussions occur annually in the U.S. related to sports and recreational activities.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Participation in contact sports, history of previous concussions, motor vehicle accidents, falls, younger age (children and adolescents).

Prognosis: The expected outcome or course of the condition over time.
Generally good, with most people recovering fully within weeks to months; symptoms may persist longer in post-concussion syndrome.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Post-concussion syndrome, second impact syndrome, chronic traumatic encephalopathy (CTE), persistent cognitive or emotional problems.

Traumatic Brain Injury (TBI)

Specialty: Neurology

Category: Traumatic Brain and Spinal Cord Injuries

Symptoms:
loss of consciousness; headache; confusion; memory loss; dizziness; vomiting; seizures; speech difficulties; weakness or numbness; changes in behavior

Root Cause:
Brain damage caused by external force, such as a blow to the head, penetration by an object, or violent shaking.

How it's Diagnosed: videos
Physical and neurological examinations, imaging tests like CT scans or MRIs, Glasgow Coma Scale assessment.

Treatment:
Emergency stabilization, surgical intervention if necessary (to relieve pressure or repair damage), physical and cognitive rehabilitation, supportive care.

Medications:
Diuretics (e.g., mannitol ) to reduce brain swelling; anticonvulsants (e.g., levetiracetam ) to prevent seizures; sedatives (e.g., propofol ) for agitation or to manage intracranial pressure.

Prevalence: How common the health condition is within a specific population.
About 2.8 million emergency department visits for TBI in the U.S. annually; common in all age groups, particularly young adults and the elderly.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Falls, vehicle accidents, sports injuries, physical violence, military combat exposure.

Prognosis: The expected outcome or course of the condition over time.
Varies widely; mild TBIs often resolve fully, while severe TBIs may result in long-term disabilities or death.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Seizures, infections, hydrocephalus, cognitive or emotional impairments, death.

Subdural Hematoma

Specialty: Neurology

Category: Traumatic Brain and Spinal Cord Injuries

Symptoms:
headache; confusion; drowsiness; vomiting; seizures; weakness; slurred speech; loss of consciousness

Root Cause:
Bleeding between the dura mater and the arachnoid membrane, typically caused by trauma to the head.

How it's Diagnosed: videos
Diagnosed through neuroimaging, primarily CT scans or MRI, to detect blood accumulation.

Treatment:
Treatment ranges from observation for mild cases to surgical intervention (craniotomy or burr hole drainage) for severe cases.

Medications:
Antiepileptic drugs (AEDs) such as levetiracetam or phenytoin may be prescribed to prevent seizures. Pain management medications like acetaminophen are also used.

Prevalence: How common the health condition is within a specific population.
Subdural hematomas are relatively common, especially among older adults and individuals on anticoagulant therapy.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Head trauma, older age, use of blood thinners, alcohol abuse, and brain atrophy.

Prognosis: The expected outcome or course of the condition over time.
Variable depending on severity and treatment; mild cases have a good prognosis, but severe cases can lead to permanent neurological impairment or death.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Increased intracranial pressure, brain herniation, chronic subdural hematoma, seizures, and cognitive deficits.

Epidural Hematoma

Specialty: Neurology

Category: Traumatic Brain and Spinal Cord Injuries

Symptoms:
brief loss of consciousness followed by a lucid interval; headache; vomiting; confusion; weakness; seizures; unequal pupil size; progressive loss of consciousness

Root Cause:
Accumulation of blood between the skull and dura mater, often due to the rupture of an artery, commonly the middle meningeal artery, from trauma.

How it's Diagnosed: videos
Diagnosed through CT scans or MRI to visualize blood collection.

Treatment:
Emergency surgical evacuation of the hematoma via craniotomy or burr hole surgery.

Medications:
Anticonvulsants like levetiracetam to prevent seizures and analgesics for pain management.

Prevalence: How common the health condition is within a specific population.
Less common than subdural hematomas but more frequently observed in younger patients with head trauma.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Skull fractures, head trauma, high-impact injuries, and anticoagulant therapy.

Prognosis: The expected outcome or course of the condition over time.
Good if treated promptly; untreated cases can lead to brain herniation and death.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Increased intracranial pressure, brain herniation, permanent neurological deficits, and death if untreated.

Pseudotumor Cerebri (Idiopathic Intracranial Hypertension)

Specialty: Neurology

Category: Other Neurological Disorders

Symptoms:
headache; blurred vision; double vision; papilledema (optic disc swelling); ringing in the ears synchronized with heartbeat

Root Cause:
Increased intracranial pressure without an identifiable mass or tumor, often linked to impaired CSF absorption.

How it's Diagnosed: videos
Fundoscopic exam for papilledema, lumbar puncture measuring elevated CSF pressure, and brain imaging to rule out other causes.

Treatment:
Weight loss, therapeutic lumbar punctures, optic nerve fenestration surgery, or CSF shunting if vision loss is severe.

Medications:
Acetazolamide (a carbonic anhydrase inhibitor) to reduce CSF production; furosemide (a diuretic) for adjunctive therapy; pain relievers for headaches.

Prevalence: How common the health condition is within a specific population.
Affects 1–2 per 100,000 people; higher incidence in obese women of childbearing age.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Obesity, female gender, certain medications (e.g., tetracycline, oral contraceptives, or corticosteroids), and hormonal changes.

Prognosis: The expected outcome or course of the condition over time.
Often manageable with treatment; untreated cases may lead to permanent vision loss.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Chronic headaches, severe vision impairment, and blindness.

Herpes zoster (shingles)

Specialty: Senior Health and Geriatrics

Category: Infectious Diseases

Sub-category: Chronic and Recurrent Infections

Symptoms:
painful, blistering rash typically on one side of the body; burning or tingling sensation; fever; headache; sensitivity to light; itching or numbness in the affected area

Root Cause:
Reactivation of the varicella-zoster virus (which causes chickenpox) in the nerve roots after a period of dormancy.

How it's Diagnosed: videos
Diagnosis is typically based on clinical presentation (painful rash, usually localized in a dermatome). Laboratory testing (e.g., PCR or direct fluorescent antibody tests) can confirm the presence of the varicella-zoster virus.

Treatment:
Antiviral medications (e.g., acyclovir, valacyclovir, famciclovir), pain management, and corticosteroids (for severe pain or inflammation). Vaccination with the shingles vaccine (Shingrix) can prevent future occurrences.

Medications:
Antiviral drugs such as acyclovir , valacyclovir , or famciclovir , which are antiviral agents used to inhibit the replication of the varicella-zoster virus. For pain management, analgesics such as acetaminophen or nonsteroidal anti-inflammatory drugs (NSAIDs) may be used, while more severe cases may require opioids or gabapentin for nerve pain.

Prevalence: How common the health condition is within a specific population.
Shingles affects about 1 in 3 people in their lifetime. The risk increases with age, particularly after 50.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Aging (older adults are at higher risk), weakened immune system (due to conditions like HIV, cancer treatments, or immunosuppressive medications), having had chickenpox (varicella) earlier in life.

Prognosis: The expected outcome or course of the condition over time.
The rash usually resolves within 2-4 weeks. However, postherpetic neuralgia (PHN), a complication involving long-term nerve pain, can persist for months or even years, especially in older adults.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Postherpetic neuralgia (PHN), vision loss (if the eye is affected), bacterial skin infections, neurological complications such as encephalitis, and facial paralysis (Ramsay Hunt syndrome).

Traumatic brain injury (TBI) from falls

Specialty: Senior Health and Geriatrics

Category: Falls, Mobility, and Frailty

Sub-category: Falls and Injuries

Symptoms:
headache; dizziness; nausea or vomiting; loss of consciousness; confusion; memory problems; difficulty concentrating; changes in mood or personality

Root Cause:
Injury to the brain caused by a blow or jolt to the head, often from falls, which may result in contusions, concussions, or more severe brain damage.

How it's Diagnosed: videos
Diagnosis is based on clinical symptoms, physical examination, and imaging studies such as CT scans or MRIs to detect brain injury.

Treatment:
Treatment varies based on the severity of the injury, ranging from observation and rest to surgical intervention for severe brain injury.

Medications:
Medications for TBI may include pain relievers (acetaminophen or ibuprofen ), anticonvulsants if seizures are present, and antidepressants if mood disorders develop. Antiemetics (e.g., ondansetron ) may be used for nausea.

Prevalence: How common the health condition is within a specific population.
TBI is a leading cause of injury-related morbidity in older adults, especially those with balance issues or frailty.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Age (especially over 65), previous history of TBI, frailty, falls, anticoagulant use, and environmental hazards.

Prognosis: The expected outcome or course of the condition over time.
Recovery from TBI can range from full recovery to long-term cognitive and physical impairments, depending on the severity of the injury. Older adults often have a slower recovery process.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Long-term complications can include cognitive impairment, memory loss, post-concussion syndrome, and an increased risk of dementia or other neurological disorders. There may also be an increased risk of recurrent falls.

Concussion (Mild Traumatic Brain Injury)

Specialty: Trauma and Injuries

Category: Head and Neck Injuries

Sub-category: Head Injuries

Symptoms:
headache; dizziness or balance problems; nausea and vomiting; sensitivity to light or noise; difficulty concentrating or memory problems; fatigue; sleep disturbances (sleeping more or less than usual); irritability or mood changes

Root Cause:
A concussion is a mild form of traumatic brain injury caused by a blow or jolt to the head, resulting in temporary disruption of brain function. This leads to altered brain activity but usually without structural damage.

How it's Diagnosed: videos
Diagnosis is primarily clinical, based on symptoms and history of head injury. A neurological exam and cognitive testing may be used. In some cases, CT or MRI scans may be used to rule out more serious brain injuries.

Treatment:
Treatment focuses on rest and gradual return to normal activity. Cognitive and physical rest is recommended in the first 24-48 hours, followed by a gradual increase in activity. It is important to avoid returning to sports or activities that may lead to further injury during the recovery period.

Medications:
Medications are typically used to manage symptoms, such as - Pain relievers like acetaminophen (Tylenol ) for headaches. (Class

Prevalence: How common the health condition is within a specific population.
Concussions are common, especially in sports and high-risk activities. It is estimated that there are about 3 million concussions in the U.S. each year.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Participation in contact sports (e.g., football, hockey), history of prior concussions, age (children and adolescents are more vulnerable), lack of protective equipment.

Prognosis: The expected outcome or course of the condition over time.
Most people recover fully within a few weeks. However, some may experience persistent symptoms (post-concussion syndrome) that last for months.

Complications: Additional problems or conditions that may arise as a result of the original condition.
In rare cases, concussions can lead to long-term complications, such as post-concussion syndrome (persistent symptoms), second-impact syndrome (a potentially fatal condition where the brain swells after a second concussion before the first has healed), or chronic traumatic encephalopathy (CTE), which can result from repeated concussions.

Subdural hematoma

Specialty: Trauma and Injuries

Category: Head and Neck Injuries

Sub-category: Traumatic intracranial hemorrhage

Symptoms:
headache; drowsiness or confusion; slurred speech; hemiparesis (weakness on one side); seizures; nausea and vomiting

Root Cause:
Bleeding between the dura mater and the arachnoid mater, often due to a tear in the bridging veins caused by trauma.

How it's Diagnosed: videos
CT scan of the head, showing a crescent-shaped hemorrhage that crosses sutures.

Treatment:
Surgical drainage (craniotomy or burr hole) for larger hematomas or if symptoms worsen. Observation in mild cases without significant mass effect.

Medications:
Pain relief with acetaminophen or opioids. Anticonvulsants (e.g., phenytoin or levetiracetam ) to prevent seizures. Mannitol to reduce ICP if necessary.

Prevalence: How common the health condition is within a specific population.
More common than epidural hematomas and seen in 10-20% of severe TBIs.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Advanced age (more fragile bridging veins). Use of anticoagulants or antiplatelet drugs. Alcoholism (increased likelihood of falls and liver dysfunction).

Prognosis: The expected outcome or course of the condition over time.
Prognosis depends on hematoma size, severity, and timeliness of surgical intervention. Elderly patients have a poorer prognosis due to slower recovery and increased comorbidities.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Brain herniation. Long-term neurological impairment. Post-traumatic epilepsy.

Depressed skull fractures

Specialty: Trauma and Injuries

Category: Head and Neck Injuries

Sub-category: Skull fractures

Symptoms:
visible depression in the skull; localized pain; possible swelling or bruising; headache; nausea or vomiting; signs of neurological impairment like confusion or loss of consciousness

Root Cause:
A depressed skull fracture occurs when a portion of the skull is pushed inward, typically from a direct blow to the head. This type of fracture can lead to brain injury.

How it's Diagnosed: videos
Diagnosis is made through physical examination and imaging studies, primarily CT scans or X-rays, to assess the depth of the depression and any brain involvement.

Treatment:
Treatment often requires surgery to lift the bone fragment and prevent further injury to the brain. Intracranial pressure monitoring and treatment may be necessary if there is brain damage.

Medications:
Analgesics such as acetaminophen or ibuprofen are commonly prescribed. In severe cases, corticosteroids like dexamethasone may be used to reduce swelling around the brain. These are anti-inflammatory and pain management medications.

Prevalence: How common the health condition is within a specific population.
Depressed skull fractures are less common than linear fractures but are more severe and are often associated with high-energy trauma such as falls or assaults.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Risk factors include high-impact head trauma, including motor vehicle accidents, physical altercations, or sports injuries.

Prognosis: The expected outcome or course of the condition over time.
The prognosis depends on the severity of the brain injury. With prompt treatment, patients can recover, though there may be lasting neurological effects depending on the extent of the injury.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Complications can include brain hemorrhage, infection, long-term neurological deficits, and seizures.

Basilar skull fractures

Specialty: Trauma and Injuries

Category: Head and Neck Injuries

Sub-category: Skull fractures

Symptoms:
raccoon eyes (bruising around the eyes); battle's sign (bruising behind the ear); bleeding from the nose, mouth, or ears; csf (cerebrospinal fluid) leakage from the ears or nose; dizziness; headache; loss of consciousness

Root Cause:
A basilar skull fracture is a break at the base of the skull, which can affect the brainstem and cranial nerves. It is often caused by high-impact trauma.

How it's Diagnosed: videos
Diagnosis is confirmed through imaging studies, such as CT scans or MRIs, as well as clinical symptoms like CSF leakage. Physical examination may show signs like raccoon eyes or Battle's sign.

Treatment:
Treatment focuses on managing the fracture and any associated brain injury. In some cases, surgery may be required to repair the skull and stop CSF leakage. Other treatments may include antibiotics to prevent infection.

Medications:
Medications like analgesics (acetaminophen or ibuprofen ) may be used for pain management. If there is infection risk (e.g., CSF leakage), antibiotics such as ceftriaxone (a broad-spectrum antibiotic) may be prescribed to prevent meningitis.

Prevalence: How common the health condition is within a specific population.
Basilar skull fractures are relatively rare but are typically associated with high-velocity impacts such as car accidents, falls from great heights, or physical assaults.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Risk factors include severe head trauma, particularly in motor vehicle accidents or falls.

Prognosis: The expected outcome or course of the condition over time.
The prognosis can vary. If brainstem injury occurs, the outcome may be poor, with potential for long-term neurological deficits or death. However, with timely intervention, many patients recover without permanent impairment.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Complications may include infection (such as meningitis), cranial nerve damage, hearing loss, vision problems, or long-term cognitive and physical deficits.

Subdural hematomas from falls

Specialty: Trauma and Injuries

Category: Geriatric Trauma

Sub-category: Common Geriatric Injuries

Symptoms:
headache; nausea and vomiting; confusion or altered mental status; seizures; weakness or numbness in limbs

Root Cause:
Subdural hematomas occur when blood vessels between the brain and the dura mater (the outermost layer of the brain) are torn, typically due to a head injury from a fall. In the elderly, the brain may shrink, increasing the risk of bleeding.

How it's Diagnosed: videos
Diagnosis is made through imaging studies such as CT scans or MRIs of the brain to visualize the location and size of the hematoma.

Treatment:
Treatment often involves surgical intervention to drain the hematoma if it is large or causing significant pressure on the brain. Conservative management may include monitoring and medications to reduce swelling and control symptoms.

Medications:
Medications can include anticonvulsants (e.g., levetiracetam ) to prevent seizures, pain medications (opioids for severe pain), and corticosteroids (e.g., dexamethasone ) to reduce brain swelling. Anticonvulsants are classified as antiepileptic drugs, opioids are narcotic analgesics, and corticosteroids are anti-inflammatory drugs.

Prevalence: How common the health condition is within a specific population.
Subdural hematomas are common among elderly individuals who experience falls, with an estimated 10-30% of older adults with a head injury developing a subdural hematoma.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Risk factors include advanced age, use of anticoagulants or antiplatelet drugs, history of alcohol use, and prior brain injuries. A higher frequency of falls in the elderly also increases the risk.

Prognosis: The expected outcome or course of the condition over time.
The prognosis depends on the severity and size of the hematoma, as well as the speed of intervention. With prompt treatment, many individuals can recover, but severe cases can result in permanent neurological deficits or death.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Complications include long-term cognitive impairments, neurological deficits, seizures, and in some cases, death.

Metabolic Acidosis

Specialty: Nephrology

Category: Acid-Base Disorders

Symptoms:
rapid breathing (kussmaul respirations); fatigue; confusion; headache; nausea; vomiting; low blood pressure in severe cases

Root Cause:
Accumulation of acid or loss of bicarbonate in the body due to kidney dysfunction, increased acid production, or bicarbonate loss.

How it's Diagnosed: videos
Blood gas analysis (low pH, low bicarbonate), anion gap calculation, and electrolyte tests.

Treatment:
Address the underlying cause (e.g., correcting lactic acidosis or ketoacidosis), bicarbonate therapy in severe cases, and supportive care.

Medications:
Sodium bicarbonate (buffer agent), dichloroacetate (used experimentally in certain types of metabolic acidosis).

Prevalence: How common the health condition is within a specific population.
Common in hospitalized patients, particularly those in critical care settings.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Chronic kidney disease, diabetes (ketoacidosis), sepsis, and diarrhea.

Prognosis: The expected outcome or course of the condition over time.
Dependent on the underlying cause; prompt treatment generally leads to a favorable outcome.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Cardiac arrhythmias, shock, and multiorgan failure if untreated.

Respiratory Acidosis (secondary to renal issues)

Specialty: Nephrology

Category: Acid-Base Disorders

Symptoms:
confusion; fatigue; shortness of breath; headache; cyanosis; drowsiness; tremors

Root Cause:
Impaired CO2 elimination by the lungs, with kidneys unable to adequately compensate by increasing bicarbonate reabsorption.

How it's Diagnosed: videos
Blood gas analysis (low pH, elevated pCO2), kidney function tests, and imaging of the lungs.

Treatment:
Improve ventilation (mechanical ventilation if needed), treat underlying renal dysfunction, and correct any electrolyte imbalances.

Medications:
Bronchodilators (e.g., albuterol for reversible airway obstruction), bicarbonate therapy (in severe cases).

Prevalence: How common the health condition is within a specific population.
More common in patients with chronic lung disease and renal dysfunction.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Chronic obstructive pulmonary disease (COPD), renal failure, and neuromuscular disorders.

Prognosis: The expected outcome or course of the condition over time.
Dependent on the reversibility of the underlying causes; timely intervention improves outcomes.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Coma, cardiac arrhythmias, and respiratory failure.

HELLP Syndrome

Specialty: Nephrology

Category: Other Renal-Associated Conditions

Sub-category: Pregnancy-Related Kidney Conditions

Symptoms:
right upper abdominal pain; nausea; vomiting; headache; swelling; high blood pressure; fatigue; visual disturbances

Root Cause:
Severe form of preeclampsia characterized by hemolysis (H), elevated liver enzymes (EL), and low platelet count (LP). It reflects systemic endothelial dysfunction and microangiopathy.

How it's Diagnosed: videos
Blood tests showing hemolysis (schistocytes on blood smear), elevated liver enzymes (AST/ALT), low platelet count (<100,000/µL), and signs of end-organ damage; urine tests for proteinuria; imaging if indicated.

Treatment:
Delivery of the baby as the definitive treatment; supportive care with blood pressure management, magnesium sulfate for seizure prevention, and transfusions (platelets, red blood cells) if necessary.

Medications:
Antihypertensives such as labetalol or nifedipine , magnesium sulfate (anticonvulsant), and corticosteroids (e.g., dexamethasone ) to improve platelet count and fetal lung maturity.

Prevalence: How common the health condition is within a specific population.
Occurs in approximately 0.5-0.9% of pregnancies, often associated with severe preeclampsia.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
History of preeclampsia, multiple pregnancies, obesity, pre-existing hypertension, or autoimmune disorders.

Prognosis: The expected outcome or course of the condition over time.
Favorable with prompt delivery and management; however, maternal and fetal morbidity or mortality risk is higher without early intervention.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Disseminated intravascular coagulation (DIC), liver rupture, kidney failure, stroke, placental abruption, preterm delivery, or maternal and fetal death.

Internal Jugular Vein Thrombosis (IJVT)

Specialty: Hematology

Category: Coagulation, Hemostasis, and Disorders

Symptoms:
neck pain or tenderness; swelling along the neck; difficulty swallowing (dysphagia); visible neck vein distention; headache; fever if associated with infection; pulmonary symptoms in cases of embolism

Root Cause:
Formation of a blood clot in the internal jugular vein, often secondary to trauma, central venous catheterization, malignancy, infection, or hypercoagulable states. This can impair venous drainage and lead to complications like pulmonary embolism or septic thrombophlebitis.

How it's Diagnosed: videos
Ultrasound with Doppler imaging is the primary diagnostic tool. CT or MRI venography can be used for further assessment. Blood tests for D-dimer and hypercoagulable states may aid diagnosis.

Treatment:
Anticoagulation therapy with low-molecular-weight heparin (LMWH) or direct oral anticoagulants (DOACs) is the cornerstone of treatment. Antibiotics are added if infection is suspected. In rare cases, surgical intervention (thrombectomy) is needed.

Medications:
Anticoagulation Therapy - Low-Molecular-Weight Heparin (LMWH) (e.g., enoxaparin ) or unfractionated heparin (UFH) initially, Transition to oral anticoagulants like warfarin or Direct Oral Anticoagulants (DOACs) (e.g., rivaroxaban , apixaban ) for maintenance therapy. Antibiotics (if IJVT is associated with infection) - Broad-spectrum antibiotics are used, particularly if Lemierre’s syndrome (IJVT associated with Fusobacterium necrophorum) is suspected. Thrombolysis or Surgical Intervention - Considered in severe cases with extensive thrombosis or complications like pulmonary embolism.

Prevalence: How common the health condition is within a specific population.
Rare, with an estimated incidence of 0.2–1 per 100,000 people annually. It is more common in hospitalized patients with risk factors like central venous catheters or cancer.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Central venous catheterization, head and neck infections (e.g., Lemierre’s syndrome), malignancy, trauma, hypercoagulable disorders, and intravenous drug use.

Prognosis: The expected outcome or course of the condition over time.
Generally favorable with prompt treatment, although delayed diagnosis can lead to serious complications like pulmonary embolism or septicemia.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Pulmonary embolism, septic thrombophlebitis (Lemierre's syndrome), venous congestion, and, in rare cases, death.

Hyperviscosity Syndrome

Specialty: Hematology

Category: Blood Disorders

Symptoms:
blurred vision; headache; dizziness; nosebleeds; easy bruising; fatigue; altered mental status

Root Cause:
Increased blood viscosity due to elevated levels of proteins (e.g., IgM in Waldenström macroglobulinemia), red blood cells, or other components.

How it's Diagnosed: videos
Blood tests (e.g., serum viscosity levels, CBC), clinical symptoms, and testing for underlying disorders like monoclonal gammopathies.

Treatment:
Plasma exchange (plasmapheresis) to reduce viscosity, treatment of the underlying cause (e.g., chemotherapy for plasma cell disorders).

Medications:
Chemotherapy agents (e.g., rituximab for lymphoproliferative disorders), antiplatelet agents like aspirin (to reduce clotting risk).

Prevalence: How common the health condition is within a specific population.
Rare; associated with specific conditions like Waldenström macroglobulinemia and polycythemia vera.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Plasma cell dyscrasias, polycythemia vera, multiple myeloma, high serum protein levels.

Prognosis: The expected outcome or course of the condition over time.
Depends on the underlying cause; reversible with timely treatment but may lead to severe complications if untreated.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Retinal vein occlusion, stroke, organ ischemia, and heart failure.

Aplastic Anemia

Specialty: Hematology

Category: Red Blood Cells and Disorders

Symptoms:
fatigue; shortness of breath; frequent infections; unexplained or easy bruising; prolonged bleeding from cuts; pale skin; dizziness; headache; rapid or irregular heartbeat

Root Cause:
A rare condition in which the bone marrow fails to produce sufficient red blood cells, white blood cells, and platelets. Causes include autoimmune damage, exposure to toxic chemicals, certain medications, radiation, viral infections, or inherited conditions.

How it's Diagnosed: videos
Blood tests showing pancytopenia (low levels of all blood cells) and reticulocytopenia (low reticulocyte count). Bone marrow biopsy confirms hypocellular (empty) or fatty bone marrow.

Treatment:
Treatment depends on severity. Mild cases may involve supportive care, while severe cases often require immunosuppressive therapy, hematopoietic stem cell transplantation (bone marrow transplant), or blood transfusions.

Medications:
Immunosuppressants (e.g., antithymocyte globulin [ATG], cyclosporine , corticosteroids), hematopoietic growth factors (e.g., filgrastim or sargramostim ), androgens (e.g., danazol ) in certain cases, and antibiotics or antifungals to prevent or treat infections.

Prevalence: How common the health condition is within a specific population.
Rare, affecting approximately 1-2 individuals per million people annually worldwide, with higher incidence in Asia.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Exposure to toxic chemicals (e.g., benzene), radiation or chemotherapy, certain medications (e.g., chloramphenicol), viral infections (e.g., hepatitis, Epstein-Barr virus), autoimmune diseases, and genetic predisposition (e.g., Fanconi anemia).

Prognosis: The expected outcome or course of the condition over time.
With treatment, prognosis varies. Bone marrow transplantation offers a potential cure for eligible patients. Immunosuppressive therapy is effective for many, though relapses can occur. Without treatment, severe aplastic anemia is often fatal.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Life-threatening infections, severe bleeding, iron overload from repeated transfusions, progression to myelodysplastic syndrome or leukemia, and organ damage from iron overload.

Methemoglobinemia

Specialty: Hematology

Category: Red Blood Cells and Disorders

Symptoms:
cyanosis (bluish skin, especially lips and fingers); shortness of breath; fatigue; confusion; headache; dizziness; tachycardia; loss of consciousness in severe cases

Root Cause:
Elevated levels of methemoglobin (an oxidized form of hemoglobin that cannot bind oxygen effectively) in the blood, leading to reduced oxygen delivery to tissues.

How it's Diagnosed: videos
Arterial blood gas analysis showing low oxygen saturation despite normal oxygen levels, co-oximetry detecting elevated methemoglobin levels, and a chocolate-brown appearance of arterial blood.

Treatment:
Treatment depends on severity. Methylene blue (an antidote) is administered intravenously in severe cases. Ascorbic acid may also help in mild cases. Removal of the causative agent (e.g., drugs or toxins) is crucial.

Medications:
Methylene blue — a reducing agent to convert methemoglobin back to functional hemoglobin. Ascorbic acid (Vitamin C) — classified as an antioxidant, used in mild chronic cases.

Prevalence: How common the health condition is within a specific population.
Rare; often seen in people exposed to oxidizing agents (e.g., nitrates, dapsone, or benzocaine). Can also be congenital due to genetic mutations.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
exposure to oxidizing drugs or chemicals; genetic predisposition (e.g., cytochrome b5 reductase deficiency); infants under 6 months (due to immature enzyme systems); industrial exposure to nitrates

Prognosis: The expected outcome or course of the condition over time.
Prognosis is excellent with prompt treatment. Chronic or untreated cases may result in tissue hypoxia and severe complications.

Complications: Additional problems or conditions that may arise as a result of the original condition.
hypoxia; seizures; cardiovascular collapse; death in severe untreated cases

Essential Thrombocytosis

Specialty: Hematology

Category: Stem Cells and Disorders

Symptoms:
headache; dizziness; visual disturbances; burning pain in hands and feet; easy bruising; nosebleeds; blood clots

Root Cause:
Overproduction of platelets by megakaryocytes in the bone marrow, often due to mutations in the JAK2, CALR, or MPL genes.

How it's Diagnosed: videos
Blood tests showing elevated platelet count, bone marrow biopsy, and genetic testing for driver mutations.

Treatment:
Low-dose aspirin for symptom relief, cytoreductive therapy (e.g., hydroxyurea), or interferon-alpha for high-risk patients.

Medications:
Hydroxyurea (antineoplastic agent) to reduce platelet count and low-dose aspirin (antiplatelet agent) to prevent clotting.

Prevalence: How common the health condition is within a specific population.
Affects approximately 1-2 per 100,000 individuals annually, typically diagnosed in older adults.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Age > 50 years, female sex, and genetic mutations (e.g., JAK2, CALR, MPL).

Prognosis: The expected outcome or course of the condition over time.
Generally favorable with treatment; life expectancy close to normal in most cases.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Blood clots, bleeding, progression to myelofibrosis or acute leukemia.

Polycythemia Vera

Specialty: Hematology

Category: Stem Cells and Disorders

Symptoms:
headache; dizziness; itching (especially after a hot shower); fatigue; blurred vision; red or flushed skin; blood clots

Root Cause:
Mutation in the JAK2 gene leads to overproduction of red blood cells, white cells, and platelets.

How it's Diagnosed: videos
Complete blood count (CBC), JAK2 mutation test, bone marrow biopsy, erythropoietin level.

Treatment:
Phlebotomy, low-dose aspirin, cytoreductive therapy with hydroxyurea or ruxolitinib.

Medications:
Hydroxyurea (cytoreductive agent), ruxolitinib (JAK2 inhibitor), low-dose aspirin (antithrombotic).

Prevalence: How common the health condition is within a specific population.
Rare; approximately 1-2 cases per 100,000 annually.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Age over 60, family history, genetic predisposition.

Prognosis: The expected outcome or course of the condition over time.
Manageable with treatment; life expectancy approaches normal with proper therapy.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Blood clots, stroke, heart attack, progression to myelofibrosis or acute leukemia.

Secondary Polycythemia

Specialty: Hematology

Category: Stem Cells and Disorders

Symptoms:
headache; dizziness; flushing; itching after a warm bath; shortness of breath; fatigue

Root Cause:
Excess erythropoietin production due to chronic hypoxia, tumors, or other conditions that increase red blood cell production.

How it's Diagnosed: videos
CBC, erythropoietin levels, arterial blood gas, imaging to identify potential causes (e.g., tumors, lung disease).

Treatment:
Address underlying cause (e.g., oxygen therapy for hypoxia, surgical removal of tumors), phlebotomy if necessary.

Medications:
No specific medications for polycythemia itself; underlying conditions dictate treatment (e.g., erythropoiesis-stimulating agents are avoided).

Prevalence: How common the health condition is within a specific population.
More common than primary polycythemia; varies based on prevalence of causative factors like chronic lung disease.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Smoking, chronic obstructive pulmonary disease (COPD), high altitude, kidney tumors, sleep apnea.

Prognosis: The expected outcome or course of the condition over time.
Good if underlying cause is treatable; chronic cases require long-term management.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Increased risk of thrombosis, stroke, or heart attack due to elevated red blood cell count.

Cyanide poisoning

Specialty: Toxicology

Category: Acute Poisoning

Sub-category: Chemical Poisoning

Symptoms:
headache; confusion; seizures; shortness of breath; cardiac arrhythmias; cherry-red skin coloration (rare); metabolic acidosis; coma

Root Cause:
Inhibition of cytochrome c oxidase in the mitochondria, leading to cellular hypoxia and metabolic failure despite adequate oxygenation.

How it's Diagnosed: videos
Clinical history of exposure, symptoms presentation, blood cyanide levels, and arterial blood gases (showing metabolic acidosis).

Treatment:
Administration of hydroxocobalamin (binds cyanide to form cyanocobalamin), sodium thiosulfate (enhances cyanide detoxification), and supportive care (oxygen therapy).

Medications:
Hydroxocobalamin (cyanide antidote), sodium thiosulfate (sulfur donor for detoxification), amyl nitrite or sodium nitrite (optional, promotes methemoglobin formation).

Prevalence: How common the health condition is within a specific population.
Rare in industrialized countries but associated with fires, industrial exposure, and intentional poisoning.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Smoke inhalation from fires, occupational exposure (e.g., mining, metal plating), ingestion of cyanide-containing compounds.

Prognosis: The expected outcome or course of the condition over time.
Good with rapid intervention; delay in treatment can result in death.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Neurological damage, cardiopulmonary arrest, lactic acidosis.

Carbon monoxide poisoning

Specialty: Toxicology

Category: Acute Poisoning

Sub-category: Chemical Poisoning

Symptoms:
headache; dizziness; nausea; vomiting; confusion; chest pain; shortness of breath; loss of consciousness; seizures; coma

Root Cause:
Carbon monoxide binds to hemoglobin with greater affinity than oxygen, forming carboxyhemoglobin, which reduces oxygen delivery to tissues and causes cellular hypoxia.

How it's Diagnosed: videos
Clinical history, carboxyhemoglobin levels via blood gas analysis, pulse CO-oximetry (if available).

Treatment:
Removal from exposure source, administration of 100% oxygen, hyperbaric oxygen therapy in severe cases.

Medications:
No specific medications; 100% oxygen or hyperbaric oxygen therapy is the treatment of choice.

Prevalence: How common the health condition is within a specific population.
Common, particularly in poorly ventilated areas with gas heaters, car exhaust, or during fire incidents.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Indoor use of gas appliances, fires, motor vehicle exhaust, faulty heating systems.

Prognosis: The expected outcome or course of the condition over time.
Excellent with early treatment; delayed treatment can result in neurological sequelae or death.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Hypoxic brain injury, delayed neuropsychiatric syndrome (DNS), arrhythmias, myocardial ischemia.

Methanol Poisoning

Specialty: Toxicology

Category: Acute Poisoning

Sub-category: Alcohol-Related Toxicity

Symptoms:
headache; nausea; vomiting; blurred vision; metabolic acidosis; confusion; seizures; blindness; coma

Root Cause:
Metabolism of methanol to formic acid leads to severe metabolic acidosis and optic nerve toxicity.

How it's Diagnosed: videos
Measurement of serum methanol levels, metabolic acidosis with increased anion and osmolal gap, and clinical symptoms.

Treatment:
Administration of fomepizole or ethanol to inhibit alcohol dehydrogenase, correction of acidosis with bicarbonate, and hemodialysis to remove methanol and formic acid.

Medications:
Fomepizole or ethanol (alcohol dehydrogenase inhibitors); sodium bicarbonate for acidosis.

Prevalence: How common the health condition is within a specific population.
Rare; occurs due to ingestion of adulterated alcohol or industrial exposure.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Access to methanol-containing products, substance misuse, occupational hazards.

Prognosis: The expected outcome or course of the condition over time.
With early treatment, prognosis is good; delayed treatment can result in blindness or death.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Permanent blindness, multi-organ failure, death.

Pesticide Poisoning (Chronic Exposure)

Specialty: Toxicology

Category: Chronic Toxicity and Long-Term Exposures

Sub-category: Occupational and Environmental Exposures

Symptoms:
headache; nausea; fatigue; memory loss; mood changes; peripheral neuropathy; respiratory issues; dermatitis

Root Cause:
Chronic exposure to pesticides leads to bioaccumulation, oxidative stress, and neurotoxicity, potentially affecting multiple organ systems.

How it's Diagnosed: videos
Patient history, blood/urine analysis for pesticide metabolites, and neurological assessments.

Treatment:
Removing the source of exposure, supportive care, antioxidant therapy, and chelation therapy in some cases.

Medications:
Atropine (an anticholinergic) and pralidoxime (a cholinesterase reactivator) are used for organophosphate poisoning. Antioxidants like vitamin E and N-acetylcysteine may mitigate oxidative damage.

Prevalence: How common the health condition is within a specific population.
Prevalent among agricultural workers and individuals in areas of high pesticide use.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Occupational exposure, inadequate protective equipment, and prolonged exposure.

Prognosis: The expected outcome or course of the condition over time.
Varies based on severity and duration of exposure; long-term effects can include neurological deficits and chronic respiratory conditions.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Neurological disorders, endocrine disruption, infertility, and cancer.

Polycyclic Aromatic Hydrocarbons (PAHs) Exposure

Specialty: Toxicology

Category: Chronic Toxicity and Long-Term Exposures

Sub-category: Occupational and Environmental Exposures

Symptoms:
skin irritation; respiratory issues; fatigue; headache; nausea; chronic cough

Root Cause:
Bioactivation of PAHs into reactive metabolites causes DNA damage, oxidative stress, and inflammation.

How it's Diagnosed: videos
Biomonitoring of PAHs metabolites in urine or blood, occupational and environmental history, and imaging studies for organ-specific symptoms.

Treatment:
Avoiding exposure, dietary antioxidants, symptomatic treatment, and monitoring for cancer development.

Medications:
No specific medications; supportive care and antioxidants like vitamin C and glutathione precursors may help reduce oxidative damage.

Prevalence: How common the health condition is within a specific population.
Common among industrial workers, smokers, and those living in polluted environments.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Exposure to combustion products, industrial processes, smoking, and dietary intake of charred foods.

Prognosis: The expected outcome or course of the condition over time.
Chronic exposure increases cancer risk (lung, skin, bladder). Early cessation of exposure improves outcomes.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Cancer, chronic respiratory diseases, and immune dysfunction.

Solvent Toxicity (e.g., Benzene, Toluene)

Specialty: Toxicology

Category: Chronic Toxicity and Long-Term Exposures

Sub-category: Occupational and Environmental Exposures

Symptoms:
headache; dizziness; confusion; memory loss; nausea; fatigue; respiratory distress; skin irritation

Root Cause:
Prolonged exposure to solvents causes central nervous system depression, bone marrow suppression, and organ toxicity.

How it's Diagnosed: videos
Blood tests for solvent levels or metabolites, bone marrow biopsy, and neurological assessments.

Treatment:
Avoidance of exposure, supportive care, and treating complications (e.g., bone marrow suppression).

Medications:
Chelating agents like dimercaprol or succimer may be used for heavy solvent exposure with metal components. Symptomatic treatments include antiemetics for nausea or anxiolytics for agitation.

Prevalence: How common the health condition is within a specific population.
Found in industrial settings (painting, printing, chemical production); exposure is common globally.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Occupational exposure, inadequate ventilation, improper handling of solvents.

Prognosis: The expected outcome or course of the condition over time.
Varies with exposure level; chronic exposure may lead to irreversible organ damage or cancer.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Leukemia (benzene exposure), kidney or liver damage, and neurological disorders.

Toxic effects of solvents (e.g., paint thinners, glues)

Specialty: Toxicology

Category: Acute and Chronic Toxicity

Sub-category: Industrial Chemicals and Solvents

Symptoms:
dizziness; headache; confusion; nausea; vomiting; dermatitis; irritation of the respiratory system; fatigue; memory impairment with chronic exposure

Root Cause:
Solvents cause toxicity through inhalation, ingestion, or skin absorption, leading to damage to the central nervous system, respiratory system, and skin. Chronic exposure can result in neurotoxicity.

How it's Diagnosed: videos
Diagnosis is based on exposure history, clinical symptoms, imaging (e.g., chest X-ray or MRI for neurological effects), and laboratory tests to detect solvent metabolites in blood or urine.

Treatment:
Immediate treatment involves removing the person from exposure, providing supportive care, oxygen therapy for respiratory distress, and treating systemic effects. Skin exposure requires thorough washing.

Medications:
Medications depend on symptoms

Prevalence: How common the health condition is within a specific population.
Common among industrial workers, painters, and individuals using glue for recreational inhalation ("huffing").

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Occupational exposure, recreational inhalant use, inadequate protective measures, and prolonged use in poorly ventilated spaces.

Prognosis: The expected outcome or course of the condition over time.
Acute exposures often resolve with appropriate care, but chronic exposure may lead to irreversible neurological damage.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Peripheral neuropathy, chronic headaches, liver damage, and kidney damage.

Scombroid Poisoning

Specialty: Toxicology

Category: Biological and Natural Toxins

Sub-category: Foodborne and Natural Toxins

Symptoms:
flushing; rash; headache; abdominal cramps; diarrhea; nausea; vomiting; burning or metallic taste

Root Cause:
Histamine accumulation in fish (typically tuna, mackerel, or sardines) due to improper storage or handling, leading to an allergic-like reaction.

How it's Diagnosed: videos
Diagnosis is based on clinical symptoms and history of eating improperly stored fish. Laboratory tests for elevated histamine levels in the fish can help confirm the diagnosis.

Treatment:
Antihistamines (e.g., diphenhydramine) for symptom relief, and in severe cases, epinephrine may be required for anaphylaxis-like reactions.

Medications:
Antihistamines (e.g., diphenhydramine , loratadine ) are typically prescribed. In some cases, corticosteroids or epinephrine may be used for severe reactions.

Prevalence: How common the health condition is within a specific population.
It is more common in warm climates, particularly in tropical and subtropical regions, affecting people who consume improperly stored or handled fish.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Consumption of poorly refrigerated or improperly stored scombroid fish species.

Prognosis: The expected outcome or course of the condition over time.
Generally good with prompt treatment. Symptoms often resolve within a few hours to a day.

Complications: Additional problems or conditions that may arise as a result of the original condition.
In severe cases, anaphylaxis may occur, requiring immediate medical attention.

Pesticide Residue Exposure

Specialty: Toxicology

Category: Toxic Effects of Environmental Pollutants

Sub-category: Soil and Agricultural Toxins

Symptoms:
nausea; vomiting; dizziness; headache; fatigue; skin irritation; respiratory issues

Root Cause:
Chronic or acute exposure to pesticide residues on food, in water, or in the environment leads to the accumulation of toxic substances in the body, potentially causing cellular and systemic damage.

How it's Diagnosed: videos
Diagnosed through patient history, physical examination, and laboratory tests, such as blood and urine tests to detect pesticide metabolites or biomarkers.

Treatment:
Immediate treatment involves removing the source of exposure, administering activated charcoal or gastric lavage (in acute cases), and providing supportive care for symptoms. Long-term management includes chelation therapy in severe cases and reducing exposure through dietary and environmental modifications.

Medications:
No specific antidotes for most pesticide exposures. Symptomatic treatments include atropine (anticholinergic for organophosphate poisoning), pralidoxime (cholinesterase reactivator for certain organophosphate toxicities), and anti-nausea medications such as ondansetron .

Prevalence: How common the health condition is within a specific population.
Common in agricultural regions; widespread globally due to the use of pesticides in farming. The World Health Organization estimates millions of cases of pesticide poisoning annually, with thousands of deaths.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Occupational exposure (farmers, agricultural workers), consuming non-organic produce, proximity to areas with heavy pesticide use, inadequate protective measures during pesticide application.

Prognosis: The expected outcome or course of the condition over time.
Prognosis depends on the level and duration of exposure. Acute poisoning has a good prognosis with timely treatment, but chronic exposure may result in long-term health effects, including neurological and endocrine disorders.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Chronic toxicity can lead to endocrine disruption, neurodegenerative diseases, cancer, reproductive issues, and developmental delays in children.

Accidental industrial chemical exposure

Specialty: Toxicology

Category: Occupational and Environmental Poisoning

Sub-category: Accidental Exposure

Symptoms:
skin irritation; respiratory distress; dizziness; nausea; burning sensation in eyes or throat; headache; confusion

Root Cause:
Unintended exposure to toxic chemicals (e.g., solvents, pesticides, cleaning agents) due to improper handling, leaks, or accidents in industrial settings.

How it's Diagnosed: videos
History of exposure, physical examination, toxicological screening, and air or substance sampling to identify specific chemicals.

Treatment:
Removal from exposure source, decontamination (e.g., flushing eyes or skin), supportive care (e.g., oxygen for respiratory distress), and specific antidotes if needed.

Medications:
Oxygen therapy, bronchodilators (e.g., albuterol for respiratory symptoms), corticosteroids for inflammation, or antidotes like atropine (for organophosphate poisoning). Atropine is an anticholinergic agent.

Prevalence: How common the health condition is within a specific population.
Highly variable; depends on workplace safety protocols and the type of industry. Common in agriculture, manufacturing, and chemical processing industries.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Poor industrial safety measures, lack of personal protective equipment (PPE), inadequate training on chemical handling.

Prognosis: The expected outcome or course of the condition over time.
Varies widely; mild exposures resolve with treatment, but severe cases (e.g., toxic inhalation or burns) can lead to long-term health issues or death.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Chronic lung disease, neurological impairment, organ damage, cancer (from long-term exposure to carcinogenic chemicals).

Heavy metal contamination in traditional remedies

Specialty: Toxicology

Category: Miscellaneous Toxicological Conditions

Sub-category: Herbal and Alternative Medicine Toxicity

Symptoms:
abdominal pain; nausea; vomiting; diarrhea; headache; fatigue; cognitive impairment; kidney dysfunction; anemia; peripheral neuropathy

Root Cause:
Presence of toxic heavy metals (e.g., lead, mercury, arsenic, cadmium) in traditional or alternative remedies due to contamination or intentional adulteration during manufacturing.

How it's Diagnosed: videos
Blood and urine tests to detect heavy metal levels; clinical history of remedy use; imaging or organ function tests for damage assessment.

Treatment:
Immediate discontinuation of the remedy; chelation therapy for heavy metal removal; supportive care for symptoms and organ damage management.

Medications:
Chelating agents such as dimercaprol (a chelating agent for arsenic , mercury, and lead poisoning), succimer (an oral chelator for lead poisoning), and calcium disodium EDTA (used for lead chelation therapy).

Prevalence: How common the health condition is within a specific population.
Prevalence varies geographically but is significant in regions with widespread use of unregulated traditional remedies.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Use of imported or locally made traditional remedies, lack of regulatory oversight, cultural reliance on alternative medicine, and socioeconomic factors limiting access to conventional healthcare.

Prognosis: The expected outcome or course of the condition over time.
Prognosis depends on the level and duration of exposure; early intervention improves outcomes, while delayed treatment may lead to irreversible organ damage or chronic health issues.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Chronic kidney disease, neurotoxicity, developmental delays in children, anemia, cardiovascular issues, and increased cancer risk (e.g., arsenic-related carcinogenesis).

CBRNE - Staphylococcal Enterotoxin B

Specialty: Infectious Diseases

Category: Bacterial Infections

Symptoms:
fever; chills; headache; nausea; vomiting; diarrhea; shortness of breath; potential septic shock

Root Cause:
Caused by exposure to Staphylococcus aureus enterotoxins, which act as superantigens triggering an exaggerated immune response.

How it's Diagnosed: videos
Clinical evaluation based on symptoms and potential exposure history. Laboratory confirmation by identifying enterotoxins in biological samples.

Treatment:
Supportive care (fluids, oxygen therapy). Antibiotics if secondary bacterial infection is suspected.

Medications:
Beta-lactam antibiotics such as cefazolin for secondary infections. Antipyretics like acetaminophen to reduce fever.

Prevalence: How common the health condition is within a specific population.
Rare; typically associated with bioterrorism events or foodborne outbreaks.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Occupational exposure, bioterrorism incidents, consumption of contaminated food.

Prognosis: The expected outcome or course of the condition over time.
Good with prompt supportive care; severe cases can result in complications or death if untreated.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Dehydration, respiratory failure, toxic shock syndrome.

Ehrlichiosis

Specialty: Infectious Diseases

Category: Bacterial Infections

Sub-category: Tick-Borne Diseases

Symptoms:
fever; headache; malaise; muscle aches; nausea; rash (less common)

Root Cause:
Infection by Ehrlichia species, transmitted by ticks, causing intracellular bacterial infection of white blood cells.

How it's Diagnosed: videos
Blood tests (PCR for Ehrlichia DNA, serology), complete blood count (CBC), and liver function tests.

Treatment:
Early initiation of antibiotic therapy and supportive care.

Medications:
Doxycycline (a tetracycline antibiotic) is the drug of choice.

Prevalence: How common the health condition is within a specific population.
Found primarily in areas with high tick populations, particularly in the southeastern and south-central United States.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Tick exposure, outdoor activities in endemic areas, and lack of tick precautions.

Prognosis: The expected outcome or course of the condition over time.
Excellent with prompt treatment; delays can lead to severe or fatal complications.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Respiratory distress syndrome, organ failure, and secondary infections.

Leptospirosis

Specialty: Infectious Diseases

Category: Bacterial Infections

Symptoms:
high fever; muscle pain; headache; vomiting; jaundice; red eyes; skin rash; abdominal pain

Root Cause:
Caused by infection with Leptospira species, transmitted through water contaminated by animal urine, often affecting the liver, kidneys, and lungs.

How it's Diagnosed: videos
Serology (e.g., microscopic agglutination test), polymerase chain reaction (PCR), or culture from blood, urine, or cerebrospinal fluid.

Treatment:
Antibiotics to clear the infection, supportive care for organ involvement, and management of complications such as kidney failure.

Medications:
Doxycycline or penicillin (for mild cases); intravenous ceftriaxone or penicillin G for severe cases.

Prevalence: How common the health condition is within a specific population.
Common in tropical and subtropical regions, particularly after heavy rainfall or flooding.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Exposure to contaminated water, working with animals, poor sanitation, recreational water activities.

Prognosis: The expected outcome or course of the condition over time.
Good with early treatment; severe cases (Weil's disease) have a higher risk of mortality.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Kidney damage, meningitis, liver failure, respiratory distress, and hemorrhage.

Mycoplasma Infections (Mycoplasma pneumoniae)

Specialty: Infectious Diseases

Category: Bacterial Infections

Sub-category: Atypical Pneumonia

Symptoms:
persistent dry cough; fever; sore throat; fatigue; headache; mild chest pain

Root Cause:
Caused by Mycoplasma pneumoniae, a bacterium lacking a cell wall, making it resistant to many antibiotics and leading to atypical pneumonia.

How it's Diagnosed: videos
Clinical presentation, chest X-ray, PCR for Mycoplasma DNA, or serologic testing for antibodies.

Treatment:
Antibiotic therapy effective against atypical organisms and symptomatic relief.

Medications:
Azithromycin (macrolide antibiotic), doxycycline (tetracycline-class antibiotic), or levofloxacin (fluoroquinolone antibiotic).

Prevalence: How common the health condition is within a specific population.
Responsible for 10–30% of community-acquired pneumonia cases; more common in younger populations, such as school-aged children and young adults.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Close contact in crowded settings (e.g., schools, dormitories), weakened immune system.

Prognosis: The expected outcome or course of the condition over time.
Generally good with treatment; most patients recover within a few weeks.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Severe pneumonia, encephalitis, hemolytic anemia, and skin rashes like Stevens-Johnson syndrome.

Plague

Specialty: Infectious Diseases

Category: Bacterial Infections

Symptoms:
fever; chills; headache; swollen lymph nodes (buboes); cough; shortness of breath; septic shock in severe cases

Root Cause:
Caused by Yersinia pestis, transmitted via flea bites or contact with infected animals.

How it's Diagnosed: videos
Confirmed by blood, sputum, or lymph node aspirate culture; rapid diagnostic tests for Yersinia pestis.

Treatment:
Early antibiotic therapy and supportive care are critical.

Medications:
Streptomycin (aminoglycoside) or gentamicin is the treatment of choice; alternatives include doxycycline or ciprofloxacin .

Prevalence: How common the health condition is within a specific population.
Rare in modern times but endemic in some regions of Africa, Asia, and the Americas.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Flea exposure, handling infected animals, or residing in endemic regions.

Prognosis: The expected outcome or course of the condition over time.
Good with prompt antibiotic treatment; high mortality in untreated cases.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Pneumonia, septicemia, and multi-organ failure.

Rickettsialpox

Specialty: Infectious Diseases

Category: Bacterial Infections

Sub-category: Rickettsial Diseases

Symptoms:
fever; rash; eschar at the bite site; chills; malaise; headache

Root Cause:
Caused by infection with Rickettsia akari, transmitted through bites of infected mites (rodent-associated).

How it's Diagnosed: videos
Clinical presentation, serologic tests, or PCR testing of eschar material.

Treatment:
Doxycycline is the drug of choice.

Medications:
Doxycycline (tetracycline antibiotic); chloramphenicol (alternative in cases of contraindications).

Prevalence: How common the health condition is within a specific population.
Sporadic outbreaks in urban environments with high rodent populations.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Contact with rodent-infested environments and mite bites.

Prognosis: The expected outcome or course of the condition over time.
Excellent with treatment; typically self-limiting without severe complications.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Rare; may include prolonged fever or secondary bacterial infections.

Rocky Mountain Spotted Fever (RMSF)

Specialty: Infectious Diseases

Category: Bacterial Infections

Sub-category: Rickettsial Diseases

Symptoms:
fever; headache; rash (starting on wrists and ankles); muscle aches; nausea; vomiting; confusion

Root Cause:
Caused by infection with Rickettsia rickettsii, transmitted by tick bites.

How it's Diagnosed: videos
Clinical presentation, serological testing, and PCR.

Treatment:
Immediate administration of doxycycline; treatment is started empirically based on suspicion.

Medications:
Doxycycline (tetracycline antibiotic); chloramphenicol (alternative for pregnant women in certain cases).

Prevalence: How common the health condition is within a specific population.
Endemic in the Americas, particularly in the southeastern United States.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Exposure to tick-infested areas, lack of protective clothing during outdoor activities.

Prognosis: The expected outcome or course of the condition over time.
Good with early treatment; delayed diagnosis can lead to severe complications or death.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Multi-organ failure, disseminated intravascular coagulation (DIC), or long-term neurological deficits.

Trench Fever

Specialty: Infectious Diseases

Category: Bacterial Infections

Symptoms:
recurrent fever; headache; muscle aches; bone pain (particularly in the shins); rash; fatigue

Root Cause:
Caused by Bartonella quintana, transmitted through body lice; bacteria infect endothelial cells and red blood cells.

How it's Diagnosed: videos
Blood tests to detect Bartonella quintana using PCR, serology, or culture; clinical history of exposure to lice.

Treatment:
Antibiotics such as doxycycline or erythromycin; supportive care for symptoms like fever and pain.

Medications:
Doxycycline (tetracycline class, broad-spectrum antibiotic); erythromycin (macrolide class, bacteriostatic antibiotic). Combination with gentamicin is sometimes recommended in severe cases.

Prevalence: How common the health condition is within a specific population.
Rare in developed nations but persists in settings with poor hygiene; seen among homeless populations and in war-torn areas.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Poor sanitation, exposure to lice, homelessness, military service in unsanitary conditions.

Prognosis: The expected outcome or course of the condition over time.
Typically good with treatment; symptoms can resolve within weeks, but chronic relapses may occur without appropriate care.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Endocarditis, chronic bacteremia, or recurrent episodes if untreated.

Typhoid Fever

Specialty: Infectious Diseases

Category: Bacterial Infections

Sub-category: Enteric Infections

Symptoms:
high fever; abdominal pain; diarrhea or constipation; headache; rash (rose spots); fatigue

Root Cause:
Caused by Salmonella enterica serotype Typhi, transmitted via contaminated food or water; bacteria invade intestinal lining and bloodstream.

How it's Diagnosed: videos
Blood, stool, or urine cultures; Widal test; PCR testing.

Treatment:
Antibiotics like ceftriaxone, azithromycin, or ciprofloxacin; hydration therapy.

Medications:
Ceftriaxone (third-generation cephalosporin, bactericidal); azithromycin (macrolide antibiotic); ciprofloxacin (fluoroquinolone class).

Prevalence: How common the health condition is within a specific population.
Endemic in regions with poor sanitation, especially South Asia, with millions of cases annually.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Ingesting contaminated food or water, poor sanitation, traveling to endemic areas.

Prognosis: The expected outcome or course of the condition over time.
Good with prompt antibiotic treatment; untreated cases have high mortality rates.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Intestinal perforation, sepsis, or chronic carrier state.

California Encephalitis

Specialty: Infectious Diseases

Category: CNS Infections

Symptoms:
fever; headache; nausea; vomiting; seizures; lethargy; meningeal irritation; neurological impairments in severe cases

Root Cause:
Viral infection caused by California serogroup viruses (e.g., La Crosse virus), primarily transmitted through mosquito bites.

How it's Diagnosed: videos
Clinical evaluation, lumbar puncture with cerebrospinal fluid (CSF) analysis, serologic or PCR testing for viral RNA.

Treatment:
Supportive care including antipyretics, anticonvulsants, and management of intracranial pressure.

Medications:
No specific antiviral therapy; symptomatic treatment includes antipyretics like acetaminophen and anticonvulsants like levetiracetam .

Prevalence: How common the health condition is within a specific population.
Rare; typically affects children and adolescents in endemic regions of the United States.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Exposure to mosquito bites, residence in or travel to endemic areas, outdoor activities during peak mosquito seasons.

Prognosis: The expected outcome or course of the condition over time.
Most cases resolve with supportive care, but severe cases may lead to neurological sequelae or death.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Seizures, cognitive impairment, behavioral changes, or chronic neurological deficits in severe cases.

CNS Whipple Disease

Specialty: Infectious Diseases

Category: CNS Infections

Sub-category: Rare Bacterial Infections

Symptoms:
cognitive dysfunction; ophthalmoplegia; seizures; ataxia; headache; weight loss; joint pain

Root Cause:
Caused by Tropheryma whipplei, a rare bacterial infection leading to systemic and neurological symptoms.

How it's Diagnosed: videos
PCR testing for Tropheryma whipplei in CSF or tissue biopsy, histopathology with PAS-positive macrophages, and endoscopic biopsy of the duodenum.

Treatment:
Long-term antibiotic therapy, typically starting with intravenous ceftriaxone followed by oral trimethoprim-sulfamethoxazole for one year.

Medications:
Ceftriaxone (IV beta-lactam antibiotic) followed by oral trimethoprim-sulfamethoxazole (a sulfonamide antimicrobial combination).

Prevalence: How common the health condition is within a specific population.
Extremely rare; precise prevalence is unknown but estimated at less than 1 per 1,000,000 people annually.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Middle-aged males, HLA-B27 positivity, and immunosuppression.

Prognosis: The expected outcome or course of the condition over time.
Early treatment can lead to full recovery, but delayed diagnosis increases the risk of irreversible neurological damage.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Cognitive impairment, seizures, motor dysfunction, and death if untreated.

Haemophilus Meningitis

Specialty: Infectious Diseases

Category: CNS Infections

Symptoms:
fever; stiff neck; headache; nausea; vomiting; sensitivity to light; altered mental status; seizures

Root Cause:
Bacterial infection caused by Haemophilus influenzae type b (Hib), leading to inflammation of the meninges.

How it's Diagnosed: videos
Lumbar puncture for cerebrospinal fluid analysis, Gram staining, and culture; PCR tests for Hib DNA.

Treatment:
Intravenous antibiotics and supportive care.

Medications:
Third-generation cephalosporins like ceftriaxone or cefotaxime are the antibiotics of choice. Adjunctive dexamethasone may be used to reduce inflammation.

Prevalence: How common the health condition is within a specific population.
Rare in countries with widespread Hib vaccination; still occurs in unvaccinated populations or areas with low vaccine coverage.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Lack of vaccination, young age (children under 5), weakened immune system.

Prognosis: The expected outcome or course of the condition over time.
With prompt antibiotic treatment, prognosis is good, although complications such as hearing loss may occur.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Hearing loss, intellectual disability, seizures, and death if untreated.

Herpes Simplex Encephalitis

Specialty: Infectious Diseases

Category: CNS Infections

Symptoms:
fever; headache; altered mental status; seizures; personality changes; weakness; memory disturbances

Root Cause:
Viral infection caused by herpes simplex virus (HSV-1 or HSV-2), leading to inflammation and damage to brain tissue.

How it's Diagnosed: videos
MRI showing temporal lobe abnormalities, CSF analysis with PCR to detect HSV DNA, and EEG.

Treatment:
Antiviral therapy with supportive care.

Medications:
Acyclovir (antiviral medication) is the first-line treatment.

Prevalence: How common the health condition is within a specific population.
Rare but serious, with an incidence of approximately 2–4 cases per million per year.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Prior HSV infections, immunosuppression, neonates (HSV-2), and older adults.

Prognosis: The expected outcome or course of the condition over time.
Without treatment, mortality exceeds 70%; with prompt antiviral therapy, mortality is reduced to around 20%, though neurological sequelae are common.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Persistent neurological deficits, cognitive impairments, seizures, and death if untreated.

Japanese Encephalitis

Specialty: Infectious Diseases

Category: CNS Infections

Symptoms:
fever; headache; nausea and vomiting; seizures; confusion; movement disorders; coma in severe cases

Root Cause:
Viral infection caused by the Japanese encephalitis virus (JEV), transmitted by Culex mosquitoes, leading to inflammation of the brain.

How it's Diagnosed: videos
Diagnosed through serological tests like IgM antibody capture ELISA (MAC-ELISA) in CSF or blood samples, and imaging (MRI).

Treatment:
Supportive care to manage symptoms, such as antipyretics for fever and anticonvulsants for seizures. No specific antiviral treatment.

Medications:
Supportive medications include anticonvulsants (e.g., phenytoin or levetiracetam ) and antipyretics (e.g., acetaminophen ). These are symptom-relieving drugs.

Prevalence: How common the health condition is within a specific population.
Endemic in parts of Asia and the Western Pacific; affects approximately 50,000–100,000 people annually.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Living in or traveling to endemic areas, exposure to mosquito bites, and lack of vaccination.

Prognosis: The expected outcome or course of the condition over time.
Mortality rate is 20–30%, and 30–50% of survivors have significant neurological or psychiatric sequelae.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Seizures, permanent neurological disabilities, movement disorders, and behavioral issues.

Neurological Sequelae of Infectious Endocarditis

Specialty: Infectious Diseases

Category: CNS Infections

Symptoms:
stroke-like symptoms; seizures; headache; altered mental status; focal neurological deficits; meningismus

Root Cause:
Embolic events or septic emboli originating from the infected cardiac valves can cause ischemic or hemorrhagic strokes, abscesses, and inflammation in the central nervous system (CNS).

How it's Diagnosed: videos
Clinical history, blood cultures to identify causative organism, imaging studies like MRI or CT to detect CNS involvement, echocardiography (transesophageal preferred) to assess for vegetations on heart valves.

Treatment:
Combination of prolonged intravenous antibiotics tailored to the causative organism, surgical intervention for infected valves if indicated, and supportive care for neurological complications.

Medications:
Antibiotics such as ceftriaxone , vancomycin , or gentamicin , depending on the identified pathogen (beta-lactams, glycopeptides, or aminoglycosides, respectively). Antiepileptics (e.g., levetiracetam ) if seizures occur.

Prevalence: How common the health condition is within a specific population.
Rare but significant; approximately 20–40% of patients with infectious endocarditis develop neurological complications.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Intravenous drug use, pre-existing heart valve disease, prosthetic heart valves, immunosuppression, poor dental hygiene.

Prognosis: The expected outcome or course of the condition over time.
Prognosis depends on promptness of treatment and severity of neurological complications; early intervention improves outcomes, but severe neurological deficits may persist.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Ischemic stroke, cerebral abscess, intracranial hemorrhage, meningitis, persistent neurological deficits, and risk of recurrent endocarditis.

St. Louis Encephalitis

Specialty: Infectious Diseases

Category: CNS Infections

Symptoms:
fever; headache; stiff neck; disorientation; tremors; seizures; coma in severe cases

Root Cause:
Viral infection caused by the St. Louis encephalitis virus (SLEV), transmitted by mosquitoes.

How it's Diagnosed: videos
Detection of SLEV-specific IgM antibodies in serum or cerebrospinal fluid (CSF) via ELISA; polymerase chain reaction (PCR).

Treatment:
Supportive care; no specific antiviral treatment.

Medications:
Symptomatic treatments, including antipyretics (e.g., acetaminophen ), anticonvulsants for seizures, and corticosteroids for severe inflammation (if indicated).

Prevalence: How common the health condition is within a specific population.
Sporadic outbreaks in North America, particularly in the summer and early fall.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Mosquito exposure, older age, immunosuppression, residing in endemic areas.

Prognosis: The expected outcome or course of the condition over time.
Varies; mild cases recover fully, while severe cases may have residual neurological deficits or mortality.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Persistent neurological issues, cognitive deficits, mortality in severe cases.

Tuberculous Meningitis

Specialty: Infectious Diseases

Category: CNS Infections

Symptoms:
headache; fever; nausea; vomiting; stiff neck; altered mental status; seizures

Root Cause:
Infection of the meninges by Mycobacterium tuberculosis, leading to inflammation and increased intracranial pressure.

How it's Diagnosed: videos
Lumbar puncture with CSF analysis (increased protein, low glucose, and lymphocytic predominance), imaging (MRI or CT), and microbiological tests for M. tuberculosis.

Treatment:
Long-term combination antitubercular therapy (e.g., isoniazid, rifampin, pyrazinamide, ethambutol), corticosteroids to reduce inflammation, and supportive care.

Medications:
First-line antitubercular drugs (e.g., isoniazid , rifampin ); corticosteroids (e.g., dexamethasone ) to manage inflammation.

Prevalence: How common the health condition is within a specific population.
More common in areas with high TB burden; rare in developed countries.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
HIV infection, immunosuppression, close contact with TB patients, malnutrition.

Prognosis: The expected outcome or course of the condition over time.
With early treatment, survival is possible, but delayed therapy can result in high morbidity and mortality.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Hydrocephalus, stroke, cranial nerve palsies, cognitive deficits, and death if untreated.

Venezuelan Equine Encephalitis

Specialty: Infectious Diseases

Category: CNS Infections

Symptoms:
fever; headache; nausea; vomiting; seizures; confusion; weakness; photophobia

Root Cause:
Caused by the Venezuelan equine encephalitis virus, transmitted by mosquitoes, leading to inflammation of the brain.

How it's Diagnosed: videos
Serologic tests for viral antibodies (e.g., ELISA), PCR for viral RNA, and CSF analysis.

Treatment:
Supportive care (e.g., hydration, antipyretics, and seizure control); no specific antiviral treatment available.

Medications:
Antipyretics (e.g., acetaminophen for fever); anticonvulsants (e.g., phenytoin or valproic acid for seizures).

Prevalence: How common the health condition is within a specific population.
Sporadic outbreaks in Central and South America; rare in humans, more common in equines.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Living or working in endemic areas, exposure to mosquitoes, and outdoor activities.

Prognosis: The expected outcome or course of the condition over time.
Most recover fully, but severe cases may lead to neurological deficits or death.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Long-term neurological sequelae (e.g., cognitive deficits, epilepsy), and in severe cases, death.

Viral Encephalitis

Specialty: Infectious Diseases

Category: CNS Infections

Symptoms:
fever; headache; confusion; seizures; nausea; vomiting; altered mental status; photophobia

Root Cause:
Brain inflammation caused by viral infections (e.g., herpes simplex virus, arboviruses), leading to neuronal damage.

How it's Diagnosed: videos
Clinical evaluation, CSF analysis, PCR for viral DNA/RNA, and neuroimaging (e.g., MRI).

Treatment:
Antiviral therapy for specific viruses (e.g., acyclovir for herpes simplex virus); supportive care for other viral causes.

Medications:
Acyclovir (for herpes simplex); antipyretics (e.g., ibuprofen for fever); anticonvulsants (e.g., levetiracetam for seizures).

Prevalence: How common the health condition is within a specific population.
Varies; common in areas with high mosquito-borne virus activity or sporadic herpes outbreaks.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Immunosuppression, unvaccinated status, and mosquito exposure.

Prognosis: The expected outcome or course of the condition over time.
Depends on the cause and severity; early treatment improves outcomes, but severe cases may result in lasting deficits.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Long-term neurological damage, seizures, cognitive deficits, and death if untreated.

Viral Meningitis

Specialty: Infectious Diseases

Category: CNS Infections

Symptoms:
headache; fever; neck stiffness; photophobia; nausea; vomiting

Root Cause:
Inflammation of the meninges caused by viral infections (e.g., enteroviruses, herpesviruses), leading to non-purulent inflammation.

How it's Diagnosed: videos
CSF analysis (increased lymphocytes, normal glucose, elevated protein), PCR for viral pathogens.

Treatment:
Supportive care (hydration, pain relief, antipyretics); antiviral therapy for specific causes (e.g., herpesvirus).

Medications:
Acyclovir (for herpes-related cases); over-the-counter analgesics (e.g., acetaminophen for headache and fever).

Prevalence: How common the health condition is within a specific population.
Common; most cases are mild and self-limiting.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Exposure to infected individuals, immunosuppression, and travel to endemic regions.

Prognosis: The expected outcome or course of the condition over time.
Excellent in most cases; severe outcomes are rare.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Rare; may include chronic headaches or recurrent symptoms.

West Nile Virus (WNV) Infection and Encephalitis (WNE)

Specialty: Infectious Diseases

Category: CNS Infections

Symptoms:
fever; headache; muscle weakness; fatigue; seizures; confusion; stiff neck

Root Cause:
Viral infection transmitted by mosquitoes, leading to inflammation of the brain and nervous system.

How it's Diagnosed: videos
PCR or serology for WNV in blood or CSF; neuroimaging may reveal inflammation.

Treatment:
Supportive care (hydration, pain management, seizure control); no specific antiviral therapy.

Medications:
Analgesics for pain relief (e.g., acetaminophen ); anticonvulsants (e.g., levetiracetam for seizures).

Prevalence: How common the health condition is within a specific population.
Found in many parts of the world, especially during mosquito season.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Outdoor activities, lack of mosquito control, immunosuppression.

Prognosis: The expected outcome or course of the condition over time.
Most recover, but severe cases may result in neurological deficits or death.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Chronic fatigue, cognitive impairment, and long-term neurological deficits in severe cases.

Western Equine Encephalitis (WEE)

Specialty: Infectious Diseases

Category: CNS Infections

Symptoms:
fever; headache; nausea; vomiting; seizures; altered mental status; muscle weakness

Root Cause:
Caused by the Western equine encephalitis virus, transmitted by mosquitoes, leading to inflammation of the brain and central nervous system.

How it's Diagnosed: videos
Serologic testing for viral antibodies (e.g., IgM ELISA), PCR for viral RNA, and CSF analysis.

Treatment:
Supportive care (e.g., intravenous fluids, fever control, seizure management); no specific antiviral therapy available.

Medications:
Antipyretics (e.g., ibuprofen for fever and discomfort); anticonvulsants (e.g., diazepam or levetiracetam for seizure control).

Prevalence: How common the health condition is within a specific population.
Rare; found in North and South America, with sporadic outbreaks in rural areas.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Exposure to mosquitoes in endemic regions, outdoor activities, and lack of mosquito control.

Prognosis: The expected outcome or course of the condition over time.
Most cases are mild and resolve without long-term effects; severe cases can lead to neurological deficits or death, particularly in children and the elderly.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Long-term neurological deficits (e.g., cognitive impairment, motor dysfunction), seizures, and death in severe cases.

Coccidioidomycosis and Valley Fever

Specialty: Infectious Diseases

Category: Fungal Infections

Sub-category: Endemic Mycoses

Symptoms:
fever; cough; chest pain; fatigue; headache; rash; joint pain

Root Cause:
Infection caused by Coccidioides species (C. immitis or C. posadasii) through inhalation of fungal spores, leading to localized or disseminated disease.

How it's Diagnosed: videos
Serologic testing (IgM and IgG antibodies), fungal cultures, histopathology, or PCR-based diagnostics.

Treatment:
Mild cases may resolve without treatment; moderate to severe cases require antifungal therapy, such as azoles or amphotericin B.

Medications:
Fluconazole or itraconazole for most cases. Amphotericin B is used for severe or disseminated disease. These drugs are systemic antifungal agents targeting fungal growth or membrane integrity.

Prevalence: How common the health condition is within a specific population.
Endemic in the southwestern U.S., northern Mexico, and parts of Central and South America; incidence rates vary but are increasing with climate change.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Residing or working in endemic areas, soil disturbance, immunosuppression, and pregnancy (third trimester).

Prognosis: The expected outcome or course of the condition over time.
Most cases are self-limited; severe or disseminated cases have variable outcomes, with mortality up to 30% in untreated disseminated infections.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Dissemination to skin, bones, or meninges; chronic pulmonary disease; and meningitis.

Cryptococcosis

Specialty: Infectious Diseases

Category: Fungal Infections

Sub-category: Opportunistic Mycoses

Symptoms:
fever; headache; nausea; vomiting; altered mental status; neck stiffness in meningitis; cough; chest pain

Root Cause:
Infection by Cryptococcus neoformans or Cryptococcus gattii, typically through inhalation of spores, often affecting immunocompromised individuals.

How it's Diagnosed: videos
India ink staining, cryptococcal antigen testing, fungal cultures, or molecular diagnostics.

Treatment:
Induction therapy with amphotericin B and flucytosine, followed by maintenance therapy with fluconazole.

Medications:
Amphotericin B (polyenes), flucytosine (antifungal antimetabolite), and fluconazole (azole antifungal). These target fungal membranes or DNA synthesis.

Prevalence: How common the health condition is within a specific population.
Common opportunistic infection in HIV/AIDS patients, with significant global burden in low-resource settings.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
HIV/AIDS, organ transplantation, corticosteroid use, and other immunosuppressive conditions.

Prognosis: The expected outcome or course of the condition over time.
Early treatment significantly improves outcomes, though CNS involvement can lead to high mortality (up to 70% in severe untreated cases).

Complications: Additional problems or conditions that may arise as a result of the original condition.
Cryptococcal meningitis, hydrocephalus, vision loss, and neurological deficits.

Mucormycosis (Zygomycosis)

Specialty: Infectious Diseases

Category: Fungal Infections

Symptoms:
facial pain or swelling; black or necrotic tissue in nasal passages; fever; headache; vision changes; sinus congestion or discharge

Root Cause:
Aggressive fungal infection caused by Mucorales species, often associated with compromised immune function or poorly controlled diabetes.

How it's Diagnosed: videos
Histopathology, fungal culture, and imaging studies (CT or MRI).

Treatment:
Aggressive surgical debridement and systemic antifungal therapy.

Medications:
Amphotericin B (polyene antifungal) as the first-line treatment, followed by posaconazole or isavuconazole (triazole antifungals) for maintenance therapy.

Prevalence: How common the health condition is within a specific population.
Rare; more common in immunocompromised individuals or those with uncontrolled diabetes or post-COVID-19 complications.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Diabetes, immunosuppression, organ transplant, iron overload, prolonged corticosteroid use.

Prognosis: The expected outcome or course of the condition over time.
Poor if not treated early; mortality rates are high due to rapid progression and complications.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Orbital cellulitis, cavernous sinus thrombosis, intracranial involvement, systemic fungal dissemination.

Salmonella Infection (Salmonellosis)

Specialty: Infectious Diseases

Category: Gastrointestinal Tract and Intra-abdominal Infections

Symptoms:
diarrhea; fever; abdominal cramps; nausea; vomiting; headache

Root Cause:
Infection by Salmonella bacteria, typically via contaminated food, water, or contact with infected animals.

How it's Diagnosed: videos
Stool culture, blood culture in severe cases, and molecular testing (PCR) to identify Salmonella species.

Treatment:
Supportive care with fluids and electrolytes; antibiotics (only for severe cases).

Medications:
Antibiotics like ciprofloxacin , azithromycin , or ceftriaxone for severe or systemic infections. These are classified as fluoroquinolones, macrolides, and third-generation cephalosporins, respectively.

Prevalence: How common the health condition is within a specific population.
Common worldwide; significant in developing regions due to poor sanitation.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Consumption of contaminated food, immunosuppression, and travel to endemic regions.

Prognosis: The expected outcome or course of the condition over time.
Self-limited in most cases; good with appropriate treatment for severe cases.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Dehydration, bacteremia, reactive arthritis, and localized infections (e.g., osteomyelitis).

Yellow Fever

Specialty: Infectious Diseases

Category: Gastrointestinal Tract and Intra-abdominal Infections

Symptoms:
fever; headache; muscle pain; nausea; vomiting; jaundice; abdominal pain; bleeding (e.g., from the gums or nose); organ failure in severe cases

Root Cause:
Yellow fever is caused by the yellow fever virus, a flavivirus transmitted by infected mosquitoes (primarily Aedes aegypti). It leads to systemic infection, liver damage, and subsequent jaundice and bleeding tendencies in severe cases.

How it's Diagnosed: videos
Diagnosed through serologic tests or PCR.

Treatment:
Treated supportively, as no specific antiviral therapy exists, with vaccination as a key preventive measure.

Medications:
No antiviral medications are available for yellow fever. Supportive medications include antipyretics like acetaminophen (avoid NSAIDs like ibuprofen or aspirin to reduce bleeding risks) and intravenous fluids for dehydration. Hemostatic agents may be used in cases of severe bleeding.

Prevalence: How common the health condition is within a specific population.
Yellow fever is endemic in tropical areas of Africa and South America. Annually, it causes an estimated 200,000 cases and 30,000 deaths globally, with most cases unreported.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Traveling to or living in endemic areas, lack of vaccination, and exposure to mosquito bites.

Prognosis: The expected outcome or course of the condition over time.
In mild cases, recovery occurs within days to weeks without long-term effects. Severe cases with complications like liver failure or bleeding have a mortality rate of 20–50%. Survivors of severe cases typically recover fully but may require prolonged convalescence.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Hepatic failure, renal failure, shock, disseminated intravascular coagulation (DIC), multi-organ failure, and death in severe cases.

Acute Rhinosinusitis Empiric Therapy

Specialty: Infectious Diseases

Category: HEENT Infections

Symptoms:
nasal congestion; purulent nasal discharge; facial pain/pressure; fever; headache; reduced or lost sense of smell

Root Cause:
Inflammation and infection of the paranasal sinuses, usually caused by viral or bacterial pathogens.

How it's Diagnosed: videos
Clinical history and physical examination; imaging (CT scan of sinuses) in complicated or atypical cases.

Treatment:
Supportive care, empiric antibiotics for suspected bacterial infection, and adjunctive therapies such as nasal saline irrigation and decongestants.

Medications:
First-line empiric antibiotics include amoxicillin-clavulanate (a penicillin-class antibiotic). Alternatives for penicillin-allergic patients may include doxycycline (a tetracycline-class antibiotic) or respiratory fluoroquinolones like levofloxacin or moxifloxacin .

Prevalence: How common the health condition is within a specific population.
Acute rhinosinusitis is highly common, affecting approximately 1 in 8 adults annually.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Allergies, recent upper respiratory infections, smoking, structural abnormalities (e.g., deviated septum).

Prognosis: The expected outcome or course of the condition over time.
Viral rhinosinusitis typically resolves in 7-10 days; bacterial cases improve with appropriate antibiotic therapy.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Orbital cellulitis, abscess formation, meningitis, or chronic rhinosinusitis in rare cases.

Acute Rhinosinusitis Organism-Specific Therapy

Specialty: Infectious Diseases

Category: HEENT Infections

Symptoms:
nasal congestion; purulent nasal discharge; facial pain/pressure; fever; headache; postnasal drip

Root Cause:
Infection of the sinuses by specific organisms, such as Streptococcus pneumoniae, Haemophilus influenzae, or Moraxella catarrhalis.

How it's Diagnosed: videos
Clinical signs and symptoms, culture from sinus aspirate (in severe or recurrent cases).

Treatment:
Antibiotics tailored to the identified organism; supportive care as needed.

Medications:
For S. pneumoniae and H. influenzae, amoxicillin-clavulanate is commonly used. Alternatives include cefuroxime (a second-generation cephalosporin) or levofloxacin (a fluoroquinolone). For penicillin-allergic patients, clindamycin combined with a cephalosporin may be used.

Prevalence: How common the health condition is within a specific population.
Similar to empiric acute rhinosinusitis; bacterial cases occur in approximately 0.5-2% of viral sinusitis episodes.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Immunosuppression, incomplete resolution of prior infections, recurrent upper respiratory infections.

Prognosis: The expected outcome or course of the condition over time.
Good with appropriate antibiotic therapy; untreated bacterial infections may progress to complications.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Orbital cellulitis, abscesses, or intracranial infections.

Acute Sinusitis

Specialty: Infectious Diseases

Category: HEENT Infections

Symptoms:
nasal congestion; purulent nasal discharge; facial pressure; headache; tooth pain; postnasal drip

Root Cause:
Inflammation of the sinus lining due to viral, bacterial, or fungal pathogens.

How it's Diagnosed: videos
Based on clinical presentation; imaging studies (CT or MRI) in cases of suspected complications.

Treatment:
Supportive care for viral causes; antibiotics for bacterial cases; antifungals for fungal infections.

Medications:
First-line treatment involves amoxicillin-clavulanate for bacterial sinusitis. Alternatives for allergies or resistance include doxycycline , levofloxacin , or trimethoprim-sulfamethoxazole (a sulfonamide antibiotic).

Prevalence: How common the health condition is within a specific population.
Affects up to 1 in 7 adults annually in the U.S.; most cases are viral.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Allergic rhinitis, nasal polyps, dental infections, smoking, air pollution.

Prognosis: The expected outcome or course of the condition over time.
Most cases resolve without complications; bacterial cases respond well to antibiotics.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Chronic sinusitis, orbital or intracranial infections.

Chronic Rhinosinusitis Empiric Therapy

Specialty: Infectious Diseases

Category: HEENT Infections

Symptoms:
nasal congestion; nasal discharge; facial pain or pressure; loss of smell; postnasal drip; headache; fatigue

Root Cause:
Persistent inflammation of the paranasal sinuses lasting longer than 12 weeks, often due to a combination of infection, allergy, and immune dysfunction.

How it's Diagnosed: videos
Based on clinical presentation, physical examination, nasal endoscopy, and imaging studies (CT or MRI).

Treatment:
Initial treatment with empiric broad-spectrum antibiotics, nasal corticosteroids, saline irrigation, and sometimes oral steroids. Surgical intervention (e.g., functional endoscopic sinus surgery) for refractory cases.

Medications:
Empiric antibiotics like amoxicillin-clavulanate or doxycycline for bacterial infection; nasal corticosteroids (e.g., fluticasone or mometasone ); saline nasal irrigation.

Prevalence: How common the health condition is within a specific population.
Affects approximately 1-2% of the population globally, with higher prevalence in individuals with allergies or asthma.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Allergies, asthma, smoking, environmental pollutants, nasal polyps, immunodeficiency.

Prognosis: The expected outcome or course of the condition over time.
Often chronic but manageable with medical or surgical interventions; may require ongoing treatment.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Orbital cellulitis, abscess formation, intracranial infections, and osteomyelitis in severe cases.

Central Nervous System Lymphoma in HIV

Specialty: Infectious Diseases

Category: Central Nervous System Complications in HIV

Symptoms:
headache; seizures; confusion; focal neurological deficits; behavioral changes; vision problems

Root Cause:
Epstein-Barr Virus (EBV)-associated malignancy that occurs due to severe immunosuppression in HIV patients, leading to unregulated B-cell proliferation.

How it's Diagnosed: videos
MRI or CT scan showing mass lesions, CSF cytology for malignant cells, and EBV DNA detection in CSF. Brain biopsy may be needed for definitive diagnosis.

Treatment:
High-dose methotrexate-based chemotherapy combined with ART; corticosteroids to reduce cerebral edema; radiation therapy in selected cases.

Medications:
High-dose methotrexate (antimetabolite chemotherapy), rituximab (monoclonal antibody), and corticosteroids such as dexamethasone (anti-inflammatory).

Prevalence: How common the health condition is within a specific population.
Occurs in approximately 3–5% of HIV patients with advanced immunosuppression.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
CD4 count <50 cells/mm³, untreated or poorly controlled HIV, and EBV infection.

Prognosis: The expected outcome or course of the condition over time.
Poor without treatment; survival improves with ART and aggressive lymphoma treatment but remains limited due to recurrence and systemic complications.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Intracranial pressure, seizures, cognitive impairment, and recurrence of lymphoma.

CNS Cryptococcosis in HIV

Specialty: Infectious Diseases

Category: Central Nervous System Complications in HIV

Symptoms:
headache; fever; nausea; vomiting; stiff neck; photophobia; altered mental status

Root Cause:
Opportunistic fungal infection caused by Cryptococcus neoformans or Cryptococcus gattii in immunocompromised individuals.

How it's Diagnosed: videos
CSF analysis with India ink staining, cryptococcal antigen test, fungal culture, and MRI/CT imaging for associated findings.

Treatment:
Initial treatment with amphotericin B and flucytosine for induction therapy, followed by fluconazole for consolidation and maintenance therapy; concurrent ART for HIV management.

Medications:
Amphotericin B (antifungal polyene), flucytosine (antifungal antimetabolite), fluconazole (azole antifungal).

Prevalence: How common the health condition is within a specific population.
Common in HIV patients with CD4 counts <100 cells/mm³, particularly in resource-limited settings.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Advanced HIV, environmental exposure to cryptococcal spores, lack of ART adherence.

Prognosis: The expected outcome or course of the condition over time.
High mortality if untreated; with prompt therapy, survival rates improve, though neurological sequelae may persist.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Increased intracranial pressure, hydrocephalus, and long-term cognitive deficits.

CNS Toxoplasmosis in HIV

Specialty: Infectious Diseases

Category: Central Nervous System Complications in HIV

Symptoms:
headache; seizures; confusion; fever; focal neurological deficits; lethargy

Root Cause:
Reactivation of latent infection by Toxoplasma gondii due to profound immunosuppression.

How it's Diagnosed: videos
Brain imaging (MRI or CT) showing ring-enhancing lesions, positive Toxoplasma serology (IgG), and CSF PCR for Toxoplasma gondii DNA.

Treatment:
Combination of pyrimethamine, sulfadiazine, and leucovorin; ART to restore immune function.

Medications:
Pyrimethamine (antiparasitic), sulfadiazine (antibiotic), leucovorin (folinic acid to reduce bone marrow toxicity).

Prevalence: How common the health condition is within a specific population.
Occurs in 10–30% of HIV patients with CD4 counts <100 cells/mm³, especially in those not receiving prophylaxis.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Advanced HIV, exposure to Toxoplasma (e.g., undercooked meat, cat feces), and lack of prophylactic treatment.

Prognosis: The expected outcome or course of the condition over time.
Good if treated early; untreated cases have high mortality. Residual neurological deficits may occur.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Persistent neurological deficits, seizures, or progression to coma in severe cases.

Cytomegalovirus Encephalitis in HIV

Specialty: Infectious Diseases

Category: Central Nervous System Complications in HIV

Symptoms:
headache; fever; cognitive impairment; seizures; vision changes

Root Cause:
Reactivation of latent cytomegalovirus (CMV) in the setting of severe immunosuppression.

How it's Diagnosed: videos
MRI or CT imaging, CSF analysis via lumbar puncture, and CMV PCR testing.

Treatment:
Antiviral therapy with ganciclovir or valganciclovir; immune restoration through ART.

Medications:
Ganciclovir and valganciclovir are antivirals that target CMV DNA polymerase. Foscarnet may be used in resistant cases.

Prevalence: How common the health condition is within a specific population.
Occurs in 5–10% of untreated HIV/AIDS patients.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
CD4 count less than 50 cells/micro L, untreated HIV, prior CMV infection.

Prognosis: The expected outcome or course of the condition over time.
Poor if untreated; significant improvement with early diagnosis and therapy.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Permanent cognitive deficits, vision loss, or death.

Coronavirus Disease 2019 (COVID-19)

Specialty: Infectious Diseases

Category: Lower Respiratory Tract Infections

Symptoms:
fever; cough; shortness of breath; fatigue; loss of taste or smell; muscle aches; sore throat; headache; congestion or runny nose; nausea or vomiting; diarrhea

Root Cause:
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causing inflammation, immune response dysregulation, and damage to lung and other organ tissues.

How it's Diagnosed: videos
Diagnosis is made through a combination of clinical symptoms, polymerase chain reaction (PCR) testing for SARS-CoV-2 RNA, antigen tests, chest imaging (e.g., chest X-rays or CT scans showing ground-glass opacities), and blood tests indicating inflammation or coagulopathy.

Treatment:
Treatment focuses on managing symptoms, preventing complications, and supporting organ function. Includes antiviral medications, corticosteroids, anticoagulation therapy, and supportive care (e.g., oxygen therapy, mechanical ventilation if needed). Vaccination and post-exposure prophylaxis are also key preventive measures.

Medications:
Antiviral medications - Remdesivir (nucleotide analog), Paxlovid (combination of nirmatrelvir and ritonavir ), and molnupiravir (nucleoside analog). Corticosteroids - Dexamethasone is used to reduce inflammation in severe cases. Anticoagulants - Low-molecular-weight heparin or direct oral anticoagulants (DOACs) to prevent thromboembolism. Immunomodulators - Tocilizumab (IL-6 receptor antagonist) or baricitinib (JAK inhibitor) in severe inflammatory cases.

Prevalence: How common the health condition is within a specific population.
A global pandemic affecting hundreds of millions of people since its emergence in late 2019. Prevalence varies by region, vaccination rates, and public health measures.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Older age, comorbidities such as hypertension, diabetes, cardiovascular disease, obesity, immunosuppression, and being unvaccinated or undervaccinated.

Prognosis: The expected outcome or course of the condition over time.
The majority of cases are mild to moderate, with recovery expected in a few weeks. Severe or critical cases can lead to long-term complications or death. Prognosis is improved with early diagnosis, appropriate treatment, and vaccination.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Acute respiratory distress syndrome (ARDS), thromboembolic events (e.g., pulmonary embolism, deep vein thrombosis), myocarditis, long COVID (persistent symptoms lasting weeks to months), kidney injury, neurological complications, and secondary infections.

Hantavirus Pulmonary Syndrome

Specialty: Infectious Diseases

Category: Viral Lower Respiratory Tract Infections

Symptoms:
fever; muscle aches; headache; cough; difficulty breathing; rapidly progressive respiratory failure

Root Cause:
Severe viral infection caused by hantavirus, transmitted through inhalation of aerosolized rodent urine, feces, or saliva.

How it's Diagnosed: videos
Serology for hantavirus antibodies, reverse transcription PCR, clinical history of rodent exposure, and imaging studies showing pulmonary edema.

Treatment:
Supportive care, including mechanical ventilation for respiratory distress and fluid management.

Medications:
No specific antiviral medications; ribavirin is being studied for potential use in some cases.

Prevalence: How common the health condition is within a specific population.
Rare, primarily in rural areas of the Americas with exposure to rodent habitats.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Exposure to rodent droppings, occupational risks (e.g., farming, construction), and camping or hiking in endemic regions.

Prognosis: The expected outcome or course of the condition over time.
Mortality rate is around 35-50%; early supportive care improves outcomes.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Respiratory failure, hypotensive shock, and multi-organ failure.

Legionnaires' Disease

Specialty: Infectious Diseases

Category: Lower Respiratory Tract Infections

Symptoms:
high fever; chills; cough (productive or dry); shortness of breath; muscle aches; headache; diarrhea; nausea; confusion or mental changes in severe cases

Root Cause:
Caused by infection with Legionella bacteria, commonly Legionella pneumophila. Infection occurs through inhalation of aerosolized water droplets contaminated with the bacteria.

How it's Diagnosed: videos
Diagnosis involves chest X-rays to detect pneumonia, urine antigen tests for Legionella species, sputum culture, and PCR tests. Blood tests may show abnormalities indicating infection.

Treatment:
Treated primarily with antibiotics that target Legionella, supportive care for symptoms such as oxygen therapy for breathing difficulties, and hydration for fluid balance.

Medications:
Antibiotics - Fluoroquinolones (e.g., levofloxacin , ciprofloxacin ), macrolides (e.g., azithromycin ), or tetracyclines (e.g., doxycycline ) are commonly prescribed. These are bactericidal or bacteriostatic medications effective against Legionella.

Prevalence: How common the health condition is within a specific population.
Infrequent but can occur sporadically or in outbreaks, especially in settings with poorly maintained water systems. Affects approximately 1-2 cases per 100,000 people annually in the U.S.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Age over 50, smoking, chronic lung disease, weakened immune system, history of recent travel (hotels or cruise ships with poor water system maintenance).

Prognosis: The expected outcome or course of the condition over time.
Early treatment with antibiotics results in recovery in most cases; however, severe cases, particularly in immunocompromised individuals, may lead to complications and higher mortality rates (10-15%).

Complications: Additional problems or conditions that may arise as a result of the original condition.
Respiratory failure, septic shock, multi-organ failure, long-term lung scarring, and secondary bacterial infections.

Pneumococcal Infections (Streptococcus pneumoniae)

Specialty: Infectious Diseases

Category: Lower Respiratory Tract Infections

Symptoms:
fever; chills; cough (productive or dry); shortness of breath; chest pain; fatigue; headache; confusion in severe cases

Root Cause:
Infections caused by Streptococcus pneumoniae, including pneumonia, bacteremia, and meningitis, often following viral respiratory infections or in individuals with compromised immunity.

How it's Diagnosed: videos
Chest X-ray for pneumonia, blood cultures for bacteremia, lumbar puncture for meningitis, and rapid antigen testing for S. pneumoniae.

Treatment:
Antibiotic therapy based on severity and resistance patterns, supportive care, and vaccination for prevention.

Medications:
Antibiotics - Penicillin, ceftriaxone , or vancomycin for severe cases; macrolides (e.g., azithromycin ) or fluoroquinolones for milder presentations. Vaccination - Pneumococcal conjugate vaccine (PCV13) and pneumococcal polysaccharide vaccine (PPSV23) for prevention.

Prevalence: How common the health condition is within a specific population.
A leading cause of community-acquired pneumonia worldwide, particularly in children under 5 and adults over 65.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Age extremes, chronic diseases (e.g., diabetes, COPD), smoking, immunosuppression, and absence of vaccination.

Prognosis: The expected outcome or course of the condition over time.
Good with timely treatment, though severe cases can lead to complications. Mortality is higher in meningitis or bacteremia.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Empyema, sepsis, meningitis, and hearing loss in meningitis survivors.

Psittacosis (Parrot Fever)

Specialty: Infectious Diseases

Category: Lower Respiratory Tract Infections

Symptoms:
fever; chills; headache; dry cough; muscle aches; shortness of breath; nausea; vomiting; fatigue

Root Cause:
Zoonotic infection caused by Chlamydia psittaci, typically transmitted through inhalation of dried droppings, secretions, or dust from infected birds.

How it's Diagnosed: videos
Diagnosis involves serologic testing for C. psittaci antibodies, PCR testing, and chest imaging to confirm pneumonia.

Treatment:
Antibiotic therapy is the primary treatment, often combined with supportive care for symptom relief.

Medications:
Antibiotics - Tetracyclines (e.g., doxycycline ) are the treatment of choice. Macrolides (e.g., azithromycin ) may be used as an alternative.

Prevalence: How common the health condition is within a specific population.
Rare, primarily affecting individuals in close contact with birds, such as pet owners, veterinarians, and bird handlers.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Exposure to infected birds, handling bird droppings, or working in environments with birds.

Prognosis: The expected outcome or course of the condition over time.
Good with appropriate treatment; most patients recover fully. Untreated cases can lead to severe complications.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Endocarditis, myocarditis, respiratory failure, and multi-organ dysfunction in severe cases.

Viral Pneumonia

Specialty: Infectious Diseases

Category: Lower Respiratory Tract Infections

Symptoms:
fever; cough; shortness of breath; fatigue; muscle aches; chills; headache

Root Cause:
Lung infection caused by viruses, such as influenza, respiratory syncytial virus (RSV), or coronaviruses, leading to inflammation of lung tissues and impaired oxygen exchange.

How it's Diagnosed: videos
PCR or antigen testing for the causative virus, chest X-ray or CT scan showing diffuse infiltrates, and blood tests for markers of inflammation.

Treatment:
Supportive care, including oxygen therapy, hydration, fever management, and antivirals in some cases.

Medications:
Antivirals - Oseltamivir for influenza , ribavirin for RSV in severe cases. Supportive medications - Antipyretics and bronchodilators for symptom relief.

Prevalence: How common the health condition is within a specific population.
Common during viral outbreaks, such as seasonal influenza epidemics. RSV is particularly prevalent in young children and older adults.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Young age, advanced age, chronic diseases (e.g., asthma, COPD, heart disease), smoking, and immunosuppression.

Prognosis: The expected outcome or course of the condition over time.
Most cases are mild and self-limiting. Severe cases, particularly in immunocompromised individuals, can lead to high mortality.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Respiratory failure, bacterial superinfection, ARDS, and chronic respiratory problems.

African Trypanosomiasis (Sleeping Sickness)

Specialty: Infectious Diseases

Category: Parasitic Infections

Symptoms:
fever; headache; joint pain; itching; swelling of lymph nodes; confusion; personality changes; severe sleep disturbances; neurological impairments

Root Cause:
Caused by the protozoan Trypanosoma brucei species transmitted via tsetse fly bites, leading to systemic and central nervous system infection.

How it's Diagnosed: videos
Blood smear microscopy, serological tests, lumbar puncture to detect trypanosomes in cerebrospinal fluid (CSF).

Treatment:
Antiparasitic therapy, depending on the disease stage.

Medications:
Pentamidine (for early-stage T. brucei gambiense), suramin (for early-stage T. brucei rhodesiense), melarsoprol (for late-stage CNS involvement), eflornithine , or fexinidazole (recently approved oral treatment).

Prevalence: How common the health condition is within a specific population.
Endemic to sub-Saharan Africa, with periodic outbreaks. Cases have decreased due to control programs.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Living in or traveling to endemic areas, exposure to tsetse fly habitats, and lack of protective measures.

Prognosis: The expected outcome or course of the condition over time.
Early treatment leads to recovery; untreated cases are fatal.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Neurological damage, seizures, coma, and death in advanced stages.

Babesiosis

Specialty: Infectious Diseases

Category: Parasitic Infections

Symptoms:
fever; chills; sweats; fatigue; headache; anemia; dark urine

Root Cause:
Infection with Babesia protozoa transmitted by Ixodes tick bites, leading to red blood cell destruction.

How it's Diagnosed: videos
Blood smear for Babesia parasites, PCR testing, or serological assays.

Treatment:
Combination antimicrobial therapy.

Medications:
Atovaquone (antiprotozoal) combined with azithromycin (antibiotic), or clindamycin with quinine in severe cases.

Prevalence: How common the health condition is within a specific population.
Found in areas where Ixodes ticks are prevalent, such as the northeastern and upper midwestern United States.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Tick exposure, asplenia, advanced age, and immunosuppression.

Prognosis: The expected outcome or course of the condition over time.
Good for healthy individuals; severe disease in immunocompromised or splenectomized patients can be fatal without treatment.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Hemolytic anemia, organ failure, and death in severe cases.

Malaria

Specialty: Infectious Diseases

Category: Parasitic Infections

Symptoms:
fever; chills; headache; nausea; vomiting; muscle pain; anemia; sweating; enlarged spleen

Root Cause:
Infection by Plasmodium parasites (e.g., P. falciparum, P. vivax) transmitted by infected Anopheles mosquitoes.

How it's Diagnosed: videos
Microscopy (blood smears), rapid diagnostic tests (RDTs), and polymerase chain reaction (PCR).

Treatment:
Antimalarial medications, supportive care for complications (e.g., blood transfusions for severe anemia).

Medications:
Artemisinin-based combination therapies (ACTs, e.g., artemether-lumefantrine), chloroquine (for chloroquine-sensitive strains), primaquine (for liver-stage hypnozoites), atovaquone-proguanil, and quinine .

Prevalence: How common the health condition is within a specific population.
Affects 240 million people annually, with the highest burden in sub-Saharan Africa.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Living in endemic areas, lack of insecticide-treated bed nets, poverty, and pregnancy.

Prognosis: The expected outcome or course of the condition over time.
Treatable, but severe malaria can cause death if untreated, especially in children and pregnant women.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Cerebral malaria, severe anemia, organ failure, and hypoglycemia.

Malaria Organism-Specific Therapy

Specialty: Infectious Diseases

Category: Parasitic Infections

Symptoms:
fever; chills; sweating; headache; nausea; vomiting; muscle aches; anemia

Root Cause:
Infection caused by specific Plasmodium species (P. falciparum, P. vivax, P. ovale, P. malariae, or P. knowlesi). Treatment tailored to the infecting species, drug resistance, and location.

How it's Diagnosed: videos
Microscopy, species-specific rapid diagnostic tests (RDTs), and PCR.

Treatment:
Therapy varies by species; includes addressing blood-stage parasites and dormant liver stages (P. vivax and P. ovale).

Medications:
P. falciparum - Artemisinin-based combination therapies (ACTs, e.g., artemether-lumefantrine). P. vivax - Chloroquine or ACTs for blood-stage; primaquine or tafenoquine for liver-stage hypnozoites. P. malariae and P. ovale - Similar to P. vivax protocols. P. knowlesi - Treated with ACTs or chloroquine .

Prevalence: How common the health condition is within a specific population.
Regional variations; P. falciparum most common in Africa, P. vivax predominant outside sub-Saharan Africa.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Traveling or living in endemic areas, lack of preventive measures (e.g., bed nets, prophylaxis).

Prognosis: The expected outcome or course of the condition over time.
Effective treatment reduces mortality; early diagnosis critical. Untreated cases can lead to severe complications.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Severe malaria, organ failure, cerebral malaria, hypoglycemia.

Epidural Infections (Spinal Epidural Abscess) and Subdural Infections (Subdural Empyema)

Specialty: Infectious Diseases

Category: Skin and Soft-Tissue Infections

Symptoms:
fever; back pain; neurological deficits; headache; altered mental status; seizures; weakness or numbness

Root Cause:
Bacterial or fungal infection causing pus accumulation in the epidural or subdural space, often stemming from hematogenous spread, direct trauma, or nearby infections.

How it's Diagnosed: videos
MRI with gadolinium contrast, CT scan, blood cultures, lumbar puncture (caution due to potential complications).

Treatment:
Surgical drainage or decompression, intravenous antibiotics or antifungals, supportive care for any neurological impairments.

Medications:
Empirical antibiotic therapy typically includes vancomycin (a glycopeptide) combined with ceftriaxone (a third-generation cephalosporin). Antifungal agents like amphotericin B or fluconazole may be used for fungal infections.

Prevalence: How common the health condition is within a specific population.
Rare; exact incidence is unclear but occurs more commonly in immunocompromised individuals or those with recent spinal procedures.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Diabetes, intravenous drug use, recent spinal surgery or trauma, immunosuppression, localized infections (e.g., abscess or osteomyelitis).

Prognosis: The expected outcome or course of the condition over time.
Favorable with early detection and intervention; delayed treatment can result in permanent neurological deficits or death.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Paralysis, septicemia, chronic pain, recurrent infections, and death if untreated.

Mediterranean Spotted Fever (Boutonneuse Fever)

Specialty: Infectious Diseases

Category: Skin and Soft-Tissue Infections

Symptoms:
fever; rash resembling red spots; eschar at the site of tick bite; headache; muscle pain; nausea

Root Cause:
Caused by Rickettsia conorii, transmitted through the bite of an infected tick.

How it's Diagnosed: videos
Clinical presentation, history of tick exposure, and confirmed through serological testing (indirect immunofluorescence or PCR).

Treatment:
Antibiotic therapy, primarily doxycycline.

Medications:
Doxycycline (a tetracycline antibiotic) is the primary treatment. Chloramphenicol can be used as an alternative in some cases.

Prevalence: How common the health condition is within a specific population.
Occurs mainly in the Mediterranean region, Africa, and parts of Asia; seasonal prevalence tied to tick activity.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Exposure to tick-infested areas, outdoor activities, lack of tick prevention measures.

Prognosis: The expected outcome or course of the condition over time.
Good with prompt treatment; untreated cases may result in severe complications.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Severe multi-organ failure, septic shock, myocarditis, and neurological symptoms in untreated cases.

Arenaviruses

Specialty: Infectious Diseases

Category: Viral Infections

Symptoms:
fever; headache; myalgia; nausea; vomiting; hemorrhagic symptoms in severe cases

Root Cause:
Caused by arenaviruses, which are RNA viruses transmitted through rodent hosts. Some species can cause hemorrhagic fevers.

How it's Diagnosed: videos
PCR testing, serological testing, and virus isolation in specialized laboratories.

Treatment:
Supportive care; ribavirin (an antiviral medication) may be used in some cases.

Medications:
Ribavirin , an antiviral agent classified as a nucleoside analog.

Prevalence: How common the health condition is within a specific population.
Rare but can occur in endemic regions where rodent reservoirs are prevalent.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Exposure to infected rodents, living in endemic areas, poor sanitation.

Prognosis: The expected outcome or course of the condition over time.
Depends on the specific arenavirus; Lassa fever has a case fatality rate of 1-15%. Early treatment improves outcomes.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Hemorrhagic fever, multi-organ failure, and death in severe cases.

Smallpox

Specialty: Infectious Diseases

Category: COVID-19 Reinfections

Symptoms:
high fever; rash that progresses from spots to fluid-filled blisters; headache; backache; vomiting; fatigue

Root Cause:
Caused by the variola virus, leading to severe systemic infection with a characteristic skin rash.

How it's Diagnosed: videos
Clinical diagnosis based on the characteristic rash and fever pattern; PCR testing can confirm the variola virus.

Treatment:
No specific antiviral treatment. Smallpox was eradicated in 1980 through vaccination. Supportive care for those affected.

Medications:
Antiviral treatments like tecovirimat (TPOXX), classified as an antiviral medication, are used in some cases under emergency protocols.

Prevalence: How common the health condition is within a specific population.
Smallpox was eradicated in 1980 and is no longer a public health threat.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Lack of vaccination, close contact with infected individuals.

Prognosis: The expected outcome or course of the condition over time.
Smallpox has been eradicated, but untreated infections historically had a high mortality rate.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Secondary bacterial infections, blindness, scarring, death.

Chikungunya Virus Infection

Specialty: Infectious Diseases

Category: Viral Infections

Symptoms:
fever; severe joint pain; rash; headache; nausea

Root Cause:
Caused by Chikungunya virus, transmitted by Aedes mosquitoes, leading to systemic inflammation and viral replication.

How it's Diagnosed: videos
Diagnosed via PCR, serology (IgM/IgG antibodies), or viral culture.

Treatment:
Symptomatic treatment with NSAIDs, hydration, and rest; no specific antiviral available.

Medications:
NSAIDs like ibuprofen or acetaminophen for pain and fever.

Prevalence: How common the health condition is within a specific population.
Endemic in tropical and subtropical regions; outbreaks reported globally due to travel and mosquito spread.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Living in or traveling to endemic areas, exposure to mosquito bites, lack of vector control measures.

Prognosis: The expected outcome or course of the condition over time.
Generally self-limiting; joint pain may persist for months.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Chronic arthritis, encephalitis, myocarditis, and rarely death in vulnerable populations.

H1N1 Influenza (Swine Flu)

Specialty: Infectious Diseases

Category: Respiratory Infections

Sub-category: Seasonal Influenza Variants

Symptoms:
fever; cough; sore throat; runny or stuffy nose; myalgia; fatigue; chills; headache

Root Cause:
A strain of influenza A virus that causes respiratory infection with potential for severe pulmonary complications.

How it's Diagnosed: videos
Rapid influenza diagnostic tests (RIDTs), PCR for influenza RNA, clinical presentation during outbreak seasons.

Treatment:
Antiviral therapy (e.g., oseltamivir or zanamivir), supportive care (hydration, rest, antipyretics).

Medications:
Oseltamivir (neuraminidase inhibitor), zanamivir (neuraminidase inhibitor), antipyretics like acetaminophen or ibuprofen .

Prevalence: How common the health condition is within a specific population.
Responsible for the 2009 pandemic; seasonal outbreaks continue.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Young children, elderly individuals, pregnant women, and those with chronic medical conditions.

Prognosis: The expected outcome or course of the condition over time.
Excellent in mild cases with timely treatment; severe cases can result in hospitalization or death.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Pneumonia, acute respiratory distress syndrome (ARDS), secondary bacterial infections, and multi-organ failure in severe cases.

Human Cowpox Infection

Specialty: Infectious Diseases

Category: Viral Infections

Sub-category: Zoonotic Infections

Symptoms:
skin lesions; fever; headache; muscle aches; fatigue; swollen lymph nodes; blistering rash

Root Cause:
Infection with the cowpox virus, a zoonotic poxvirus primarily transmitted from animals (particularly rodents or cats) to humans through direct contact.

How it's Diagnosed: videos
Diagnosis is based on clinical presentation and confirmed with PCR or viral culture of the lesion.

Treatment:
Symptomatic treatment; in severe cases, antiviral drugs like tecovirimat (a smallpox drug) may be used.

Medications:
Tecovirimat (a drug used to treat orthopoxvirus infections like smallpox and cowpox) and cidofovir (an antiviral). Supportive care may include analgesics and wound care.

Prevalence: How common the health condition is within a specific population.
Rare, with most cases occurring in people with direct contact with infected animals.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Animal exposure, particularly handling infected rodents or pets with cowpox lesions.

Prognosis: The expected outcome or course of the condition over time.
Generally self-limiting, with most people recovering fully; however, complications can arise if untreated.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Secondary bacterial infections, scarring, or prolonged skin lesions in immunocompromised individuals.

Lymphocytic Choriomeningitis Virus (LCMV) Infection

Specialty: Infectious Diseases

Category: COVID-19 Reinfections

Symptoms:
fever; malaise; headache; nausea; vomiting; stiff neck; photophobia; confusion

Root Cause:
Infection caused by the LCMV, a rodent-borne arenavirus, leading to aseptic meningitis or meningoencephalitis in severe cases.

How it's Diagnosed: videos
Detection of LCMV-specific antibodies in cerebrospinal fluid (CSF) or blood, PCR for viral RNA, and history of exposure to rodents.

Treatment:
Supportive care, including pain management, anti-inflammatory medications, and fluid therapy; antivirals like ribavirin may be used experimentally.

Medications:
No FDA-approved specific treatment; ribavirin (antiviral) is sometimes used off-label for severe cases.

Prevalence: How common the health condition is within a specific population.
Rare; exposure often occurs via infected rodents or their excreta, with occasional outbreaks in specific regions.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Exposure to rodents, handling pet hamsters, and living in environments with poor rodent control.

Prognosis: The expected outcome or course of the condition over time.
Generally good with supportive care; severe cases can result in neurological complications or, rarely, death.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Neurological deficits, hydrocephalus, hearing loss, and miscarriage during pregnancy.

Monkeypox (Mpox)

Specialty: Infectious Diseases

Category: COVID-19 Reinfections

Symptoms:
fever; headache; lymphadenopathy; rash progressing from macules to pustules; fatigue; muscle aches

Root Cause:
Zoonotic viral infection caused by the monkeypox virus, closely related to the smallpox virus.

How it's Diagnosed: videos
PCR for monkeypox DNA from lesion samples, electron microscopy, or viral culture.

Treatment:
Supportive care, antivirals such as tecovirimat, and prevention of secondary infections.

Medications:
Tecovirimat (antiviral) is FDA-approved for treatment. Cidofovir and brincidofovir are alternatives in severe cases.

Prevalence: How common the health condition is within a specific population.
Endemic in parts of Central and West Africa; sporadic outbreaks reported globally.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Contact with infected animals, human-to-human transmission via respiratory droplets or skin lesions, and immunosuppression.

Prognosis: The expected outcome or course of the condition over time.
Favorable in most cases; higher risk of severe outcomes in immunocompromised individuals or young children.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Secondary bacterial infections, pneumonia, encephalitis, and corneal infection leading to vision loss.

Orbivirus

Specialty: Infectious Diseases

Category: COVID-19 Reinfections

Symptoms:
fever; headache; muscle pain; rash; swelling around eyes and mouth (in severe cases); neurological symptoms (rare)

Root Cause:
Orbivirus infections are caused by double-stranded RNA viruses in the Reoviridae family. The virus is transmitted by arthropod vectors like midges, mosquitoes, or ticks, affecting humans, livestock, and wildlife. It leads to systemic inflammation and vascular damage.

How it's Diagnosed: videos
Diagnosis involves PCR or ELISA testing to detect viral RNA or antibodies in blood samples. Clinical symptoms and recent exposure to vectors are also considered.

Treatment:
No specific antiviral treatment is available. Supportive care includes managing fever and pain with analgesics and antipyretics, along with fluid replacement if necessary.

Medications:
There are no targeted medications for Orbivirus. Acetaminophen (paracetamol) may be used for fever and pain. In severe cases, corticosteroids like dexamethasone (an anti-inflammatory) may be administered to manage systemic inflammation.

Prevalence: How common the health condition is within a specific population.
Found worldwide, but prevalence varies by region. Orbivirus-related diseases, like bluetongue in animals, are common in tropical and subtropical areas.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Exposure to arthropod vectors, living in or traveling to endemic regions, outdoor activities, weakened immune system.

Prognosis: The expected outcome or course of the condition over time.
Most cases resolve without complications, but severe cases (e.g., those involving neurological symptoms) may require hospitalization.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Neurological damage, secondary infections, and systemic inflammation leading to organ damage in severe cases.

Pharyngoconjunctival Fever (PCF)

Specialty: Infectious Diseases

Category: COVID-19 Reinfections

Symptoms:
sore throat; conjunctivitis (pink eye); fever; headache; cough; runny nose; mild swelling of lymph nodes

Root Cause:
Inflammation of the pharynx and conjunctiva caused by an adenovirus infection, often affecting children and adolescents.

How it's Diagnosed: videos
Diagnosis is primarily clinical based on symptoms; laboratory tests, such as PCR (Polymerase Chain Reaction) or viral culture, can confirm adenovirus infection.

Treatment:
Treatment is symptomatic and supportive. This includes hydration, rest, and the use of over-the-counter pain relievers (e.g., acetaminophen or ibuprofen) for fever and discomfort.

Medications:
There are no specific antiviral medications for PCF, but over-the-counter medications like acetaminophen or ibuprofen may be used to manage symptoms. These medications are classified as antipyretics and analgesics.

Prevalence: How common the health condition is within a specific population.
PCF is common, particularly in school-aged children and during outbreaks. It occurs worldwide.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Close contact with infected individuals, crowded environments like schools and daycare centers, and weakened immune systems increase susceptibility.

Prognosis: The expected outcome or course of the condition over time.
The condition is typically self-limited and resolves within 1-2 weeks without complications.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Rare, but potential complications may include secondary bacterial infections like bacterial conjunctivitis or otitis media. In very rare cases, adenovirus can lead to more severe outcomes such as pneumonia or encephalitis.

Picornavirus Infections

Specialty: Infectious Diseases

Category: COVID-19 Reinfections

Symptoms:
fever; muscle aches; headache; sore throat; runny nose; cough; gastrointestinal symptoms (vomiting, diarrhea)

Root Cause:
Picornaviruses (such as enteroviruses and rhinoviruses) cause a range of infections, affecting the respiratory and gastrointestinal systems.

How it's Diagnosed: videos
Diagnosis is confirmed by laboratory tests such as PCR or viral culture. Clinical evaluation is based on symptoms.

Treatment:
Symptomatic treatment is the main approach, including rest, hydration, and use of analgesics or antipyretics to alleviate fever and pain.

Medications:
Symptomatic treatment may include analgesics (e.g., acetaminophen ) and antipyretics (e.g., ibuprofen ) to manage fever and discomfort.

Prevalence: How common the health condition is within a specific population.
Picornavirus infections are common worldwide, especially in children.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Close contact with infected individuals, crowded living conditions, and compromised immune systems.

Prognosis: The expected outcome or course of the condition over time.
The infection is usually self-limiting and resolves within a week or two. Most individuals recover fully.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Severe complications are rare but may include meningitis, encephalitis, or respiratory failure, particularly in immunocompromised individuals.

Poliomyelitis

Specialty: Infectious Diseases

Category: COVID-19 Reinfections

Symptoms:
fever; fatigue; headache; muscle weakness; paralysis (in severe cases); neck stiffness

Root Cause:
Poliovirus infects the central nervous system, leading to inflammation of the spinal cord and motor neuron damage, potentially causing paralysis.

How it's Diagnosed: videos
Diagnosis is confirmed through PCR testing or viral culture from stool samples or throat swabs.

Treatment:
There is no specific antiviral treatment for polio. Supportive care, including mechanical ventilation in cases of respiratory failure, and physical therapy to manage muscle weakness, are part of the treatment.

Medications:
No antiviral medications are available for polio. Treatment involves supportive care and pain management (e.g., acetaminophen ).

Prevalence: How common the health condition is within a specific population.
Polio has been nearly eradicated globally due to vaccination, but outbreaks still occur in regions with low vaccination rates.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Unvaccinated individuals, particularly children in developing countries, are at the highest risk.

Prognosis: The expected outcome or course of the condition over time.
With early supportive care, the prognosis can be positive for those who do not develop paralysis. Permanent disability can occur in severe cases.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Paralysis, respiratory failure, and death are potential complications. Post-polio syndrome can also occur years after recovery.

Rabies

Specialty: Infectious Diseases

Category: COVID-19 Reinfections

Symptoms:
fever; headache; agitation; hydrophobia (fear of water); paralysis; confusion; delirium; seizures

Root Cause:
Rabies is caused by the rabies virus, which attacks the nervous system, leading to encephalitis and potentially fatal encephalopathy.

How it's Diagnosed: videos
Diagnosis is confirmed by laboratory tests, including PCR, antibody detection, or brain biopsy.

Treatment:
Once symptoms appear, rabies is almost universally fatal. However, post-exposure prophylaxis (PEP) with a rabies vaccine and immunoglobulin can prevent infection if administered promptly after exposure.

Medications:
Rabies vaccine and rabies immunoglobulin (RIG) for post-exposure prophylaxis, classified as immunizations.

Prevalence: How common the health condition is within a specific population.
Rabies remains a significant issue in developing countries, particularly in Asia and Africa, due to inadequate vaccination in animals.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Animal bites or scratches from infected animals (typically dogs, bats, raccoons).

Prognosis: The expected outcome or course of the condition over time.
Without treatment, rabies is nearly always fatal after symptoms appear. Early administration of PEP is highly effective.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Once clinical symptoms occur, complications include coma, paralysis, and death.

Rhinovirus (RV) Infection (Common Cold)

Specialty: Infectious Diseases

Category: COVID-19 Reinfections

Symptoms:
sore throat; runny nose; cough; sneezing; congestion; mild fever; headache; fatigue

Root Cause:
Rhinovirus infects the upper respiratory tract, causing inflammation and an immune response.

How it's Diagnosed: videos
Diagnosis is generally based on symptoms and clinical evaluation. Testing may be performed to confirm the presence of rhinovirus.

Treatment:
Symptomatic treatment with rest, hydration, and over-the-counter medications to relieve symptoms such as pain and congestion.

Medications:
Over-the-counter medications like acetaminophen (a pain reliever and fever reducer), ibuprofen (anti-inflammatory), and decongestants (pseudoephedrine ) can be prescribed to relieve symptoms. These medications fall under analgesics, anti-inflammatory drugs, and decongestants.

Prevalence: How common the health condition is within a specific population.
Very common, with millions of cases each year worldwide, especially in the fall and winter months.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Exposure to infected individuals, weak immune system, crowded environments, and cold weather.

Prognosis: The expected outcome or course of the condition over time.
Generally self-limiting with recovery within 7-10 days. Severe cases are rare.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Secondary bacterial infections like sinusitis, ear infections, and bronchitis; exacerbation of pre-existing respiratory conditions like asthma.

Thogotoviruses/Bourbon Virus

Specialty: Infectious Diseases

Category: COVID-19 Reinfections

Symptoms:
fever; fatigue; muscle aches; headache; nausea; vomiting; rash

Root Cause:
Caused by the Bourbon virus, transmitted by ticks; results in systemic viral infection and immune response.

How it's Diagnosed: videos
Diagnosis is confirmed by PCR testing or serology to detect Bourbon virus antibodies.

Treatment:
Supportive care, including hydration, pain management, and fever control. No specific antiviral treatment.

Medications:
Acetaminophen (analgesic) and ibuprofen (anti-inflammatory) can be used to alleviate symptoms.

Prevalence: How common the health condition is within a specific population.
Extremely rare, with only a handful of cases reported in the United States.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Tick exposure, rural areas, outdoor activities in tick-endemic regions.

Prognosis: The expected outcome or course of the condition over time.
Generally mild to moderate disease; however, severe cases may lead to organ failure.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Organ failure, septic shock, death in severe cases.

Upper Respiratory Tract Infection

Specialty: Infectious Diseases

Category: COVID-19 Reinfections

Symptoms:
sore throat; cough; nasal congestion; runny nose; fever; fatigue; headache

Root Cause:
Infection of the nose, sinuses, throat, or larynx, typically caused by viruses like rhinovirus, coronavirus, or influenza.

How it's Diagnosed: videos
Clinical diagnosis based on symptoms; further testing may be done to identify the specific pathogen.

Treatment:
Supportive care, including rest, hydration, and over-the-counter medications for symptom relief.

Medications:
Acetaminophen (analgesic), ibuprofen (anti-inflammatory), decongestants (pseudoephedrine ), and antihistamines (diphenhydramine ) can be used for symptom management.

Prevalence: How common the health condition is within a specific population.
Very common, with millions of cases annually worldwide.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Exposure to infected individuals, crowded environments, weak immune system.

Prognosis: The expected outcome or course of the condition over time.
Typically self-limiting, with symptoms resolving in 7-10 days.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Secondary bacterial infections like sinusitis, bronchitis, and pneumonia.