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Sub-Category:

Hereditary Pancreatitis

Sub-category: Genetic Pancreatic Disorders

Symptoms:
recurrent episodes of abdominal pain; nausea; vomiting; jaundice; steatorrhea; chronic fatigue; weight loss

Root Cause:
Genetic mutations (e.g., PRSS1, SPINK1, CFTR) leading to abnormal pancreatic enzyme activity and recurrent inflammation of the pancreas.

How it's Diagnosed: videos
Genetic testing, family history, imaging studies (CT or MRI), and endoscopic retrograde cholangiopancreatography (ERCP).

Treatment:
Pain management, pancreatic enzyme replacement therapy (PERT), dietary modifications, and in severe cases, total pancreatectomy with islet cell autotransplantation.

Medications:
Analgesics (acetaminophen , NSAIDs, or opioids for severe pain), pancreatic enzyme supplements, antioxidants to reduce inflammation.

Prevalence: How common the health condition is within a specific population.
Rare condition, accounting for less than 1% of chronic pancreatitis cases; higher prevalence in families with known mutations.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Positive family history, specific genetic mutations (e.g., PRSS1 mutation).

Prognosis: The expected outcome or course of the condition over time.
Variable; depends on frequency and severity of episodes. Higher risk of developing diabetes and pancreatic cancer over time.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Chronic pancreatitis, pancreatic insufficiency, diabetes mellitus, pancreatic cancer.