Background

Comprehensive Symptom Navigator™

Your health assistant, simplified.

Disclaimer: This is just an assistant. It should not be used for diagnosing patients without a doctor's discretion.

Symptoms:

Number of Conditions: 151

Food Allergies

Specialty: Internal Medicine

Category: Allergic and Immunological Conditions

Symptoms:
hives; swelling of lips, face, or tongue; abdominal pain; vomiting; diarrhea; itchy throat; anaphylaxis (severe cases)

Root Cause:
Immune system overreaction to specific proteins in foods (e.g., nuts, shellfish, eggs).

How it's Diagnosed: videos
Clinical history, skin prick testing, blood tests for specific IgE antibodies, oral food challenge (under supervision).

Treatment:
Avoidance of trigger foods, emergency treatment for severe reactions.

Medications:
Antihistamines (e.g., diphenhydramine ) for mild symptoms, epinephrine autoinjector for anaphylaxis.

Prevalence: How common the health condition is within a specific population.
Affects about 6–8% of children and 2–3% of adults globally.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Family history, other allergies (e.g., asthma, eczema), early exposure to allergens.

Prognosis: The expected outcome or course of the condition over time.
Good with strict avoidance; children may outgrow some allergies.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Anaphylaxis, nutritional deficiencies if dietary restrictions are poorly managed.

Celiac Disease

Specialty: Allergies and Immunology

Category: Immunologic Disorders

Sub-category: Autoimmune Disorders

Symptoms:
diarrhea; abdominal pain; bloating; weight loss; iron deficiency anemia; fatigue; dermatitis herpetiformis (skin rash)

Root Cause:
Autoimmune reaction to gluten, causing damage to the small intestine lining and nutrient malabsorption.

How it's Diagnosed: videos
Blood tests for anti-tTG or EMA antibodies, endoscopic biopsy of the small intestine.

Treatment:
Strict lifelong gluten-free diet.

Medications:
Gluten-free diet and supplements for nutrient deficiencies.

Prevalence: How common the health condition is within a specific population.
Affects approximately 1% of the population globally.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Genetic predisposition (HLA-DQ2/DQ8), family history, other autoimmune disorders.

Prognosis: The expected outcome or course of the condition over time.
Good with adherence to a gluten-free diet; untreated cases can lead to serious complications.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Malnutrition, osteoporosis, infertility, small intestinal cancer, other autoimmune disorders.

Crohn’s Disease

Specialty: Gastrointestinal

Category: Large Intestine (Colon) Disorders

Sub-category: Inflammatory Bowel Diseases (IBD)

Symptoms:
abdominal pain; persistent diarrhea; fatigue; weight loss; fever; mouth sores; blood in stool; reduced appetite

Root Cause:
Chronic inflammation affecting any part of the gastrointestinal tract, most commonly the ileum and colon, caused by an abnormal immune response to intestinal microbiota.

How it's Diagnosed: videos
Clinical history, colonoscopy with biopsy, capsule endoscopy, CT or MRI enterography, blood tests (e.g., CRP, anemia, hypoalbuminemia), and stool tests.

Treatment:
Treatment involves anti-inflammatory medications, immune modulators, biologic therapies, dietary management, and, in some cases, surgical resection of affected bowel segments.

Medications:
Aminosalicylates (e.g., sulfasalazine , mesalamine ) for mild disease; corticosteroids (e.g., budesonide , prednisone ) for acute flares; immunomodulators (e.g., methotrexate , azathioprine ); biologics (e.g., adalimumab , ustekinumab ) targeting TNF or interleukins; antibiotics (e.g., metronidazole , ciprofloxacin ) for secondary infections or complications.

Prevalence: How common the health condition is within a specific population.
Affects about 780,000 people in the United States; incidence is rising globally, especially in developed nations.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Family history, smoking, urban lifestyle, Western diet, use of nonsteroidal anti-inflammatory drugs (NSAIDs), and younger age (typically diagnosed between 15-30 years).

Prognosis: The expected outcome or course of the condition over time.
Chronic condition with variable severity; periods of remission and exacerbation; not curable but manageable; surgery is often needed in severe cases.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Bowel obstruction, fistulas, abscesses, malnutrition, increased risk of colorectal cancer, osteoporosis, and extraintestinal manifestations like skin disorders and joint inflammation.

Ulcerative Colitis

Specialty: Gastrointestinal

Category: Large Intestine (Colon) Disorders

Sub-category: Inflammatory Bowel Diseases (IBD)

Symptoms:
persistent diarrhea; abdominal pain; rectal bleeding; urgency to defecate; fatigue; weight loss; fever

Root Cause:
Chronic inflammation and ulceration of the mucosal lining of the colon and rectum, likely due to an autoimmune response triggered by environmental and genetic factors.

How it's Diagnosed: videos
Clinical history, colonoscopy with biopsy, stool tests, blood tests (e.g., CRP, ESR), and imaging studies like CT or MRI enterography.

Treatment:
Treatment includes anti-inflammatory drugs, immune system suppressors, dietary changes, and in severe cases, surgery (proctocolectomy with ileostomy or ileal pouch-anal anastomosis).

Medications:
Aminosalicylates (e.g., mesalamine , sulfasalazine ) to reduce inflammation; corticosteroids (e.g., prednisone ) for acute flares; immunomodulators (e.g., azathioprine ) to suppress the immune response; biologics (e.g., infliximab , adalimumab ) targeting specific inflammatory pathways.

Prevalence: How common the health condition is within a specific population.
Affects approximately 1-2 million people in the United States, with incidence rates rising in many developed countries.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Family history, Caucasian or Ashkenazi Jewish ethnicity, living in urban or industrialized areas, younger age (usually diagnosed before age 30).

Prognosis: The expected outcome or course of the condition over time.
Chronic condition with periods of remission and flare-ups; manageable with treatment; surgery can be curative but has associated risks.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Increased risk of colon cancer, toxic megacolon, perforation, severe bleeding, malnutrition, and extraintestinal manifestations like arthritis and uveitis.

Hepatitis (A, B, C, Autoimmune)

Specialty: Pediatrics

Category: Gastrointestinal Disorders

Sub-category: Infectious and Autoimmune Disorders

Symptoms:
jaundice; fatigue; abdominal pain; dark urine; light-colored stool; nausea; vomiting

Root Cause:
Liver inflammation caused by viral infections (Hepatitis A, B, C) or immune-mediated attack on liver cells (Autoimmune Hepatitis).

How it's Diagnosed: videos
Blood tests (liver enzymes, viral serology, autoimmune markers), liver ultrasound, and sometimes liver biopsy.

Treatment:
Hepatitis A

Medications:
Antivirals (e.g., tenofovir , entecavir for Hepatitis B; sofosbuvir , ribavirin for Hepatitis C), corticosteroids (e.g., prednisone for Autoimmune Hepatitis), and immunosuppressants (e.g., azathioprine ).

Prevalence: How common the health condition is within a specific population.
Hepatitis A and B

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Poor hygiene (Hepatitis A), unvaccinated status (Hepatitis B), needle sharing (Hepatitis C), genetic predisposition (Autoimmune Hepatitis).

Prognosis: The expected outcome or course of the condition over time.
Hepatitis A

Complications: Additional problems or conditions that may arise as a result of the original condition.
Chronic liver disease, cirrhosis, hepatocellular carcinoma, liver failure.

Diabetic Ketoacidosis (DKA)

Specialty: Diabetes and Endocrinology

Category: Diabetes Mellitus and Related Disorders

Sub-category: Acute Complications

Symptoms:
excessive thirst; frequent urination; nausea; vomiting; abdominal pain; shortness of breath; fruity-smelling breath; confusion

Root Cause:
Insulin deficiency leads to uncontrolled hyperglycemia, lipolysis, and ketone production, causing metabolic acidosis.

How it's Diagnosed: videos
Blood tests showing high blood glucose, ketonemia, low bicarbonate, and arterial blood pH < 7.3; urine tests for ketones.

Treatment:
Intravenous fluids, insulin therapy, electrolyte replacement (potassium), and treating underlying causes (e.g., infection).

Medications:
Regular insulin administered intravenously to reduce blood glucose and ketone levels.

Prevalence: How common the health condition is within a specific population.
Common in individuals with type 1 diabetes; can occur in type 2 diabetes during severe stress.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Poor diabetes management, infection, trauma, surgery, or missed insulin doses.

Prognosis: The expected outcome or course of the condition over time.
Early treatment leads to recovery; delayed treatment may result in coma or death.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Cerebral edema, hypokalemia, arrhythmias, and death.

Adrenal insufficiency (e.g., Addison’s disease)

Specialty: Pediatrics

Category: Endocrine Disorders

Sub-category: Other Endocrine Issues

Symptoms:
fatigue; weight loss; low blood pressure; hyperpigmentation of the skin; abdominal pain; nausea; vomiting; salt cravings; hypoglycemia

Root Cause:
Insufficient production of cortisol and/or aldosterone by the adrenal glands, often due to autoimmune destruction, infection, or adrenal gland damage.

How it's Diagnosed: videos
Blood tests measuring cortisol and ACTH levels, ACTH stimulation test, electrolyte panels, and imaging studies (e.g., CT or MRI of the adrenal glands).

Treatment:
Hormone replacement therapy, including glucocorticoids (e.g., hydrocortisone) and mineralocorticoids (e.g., fludrocortisone), along with lifestyle adjustments and emergency injectable hydrocortisone for adrenal crises.

Medications:
Hydrocortisone or prednisone (glucocorticoids) replace cortisol; fludrocortisone (a mineralocorticoid) replaces aldosterone. Glucocorticoids are corticosteroids, while fludrocortisone is a mineralocorticoid.

Prevalence: How common the health condition is within a specific population.
Rare, affecting approximately 1 in 10,000 to 20,000 people globally.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Autoimmune conditions (e.g., autoimmune polyendocrine syndrome), family history, infections (e.g., tuberculosis), adrenal gland damage due to trauma or surgery.

Prognosis: The expected outcome or course of the condition over time.
With appropriate treatment, patients can lead normal lives; however, untreated adrenal insufficiency can be life-threatening.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Adrenal crisis (acute life-threatening condition), electrolyte imbalances, hypoglycemia, and increased susceptibility to stress-related illnesses.

Wilms' Tumor (Nephroblastoma)

Specialty: Pediatrics

Category: Hematologic and Oncologic Disorders

Sub-category: Oncologic Conditions

Symptoms:
abdominal mass or swelling; abdominal pain; blood in the urine (hematuria); fever; nausea; loss of appetite; high blood pressure

Root Cause:
Malignant tumor originating from embryonal kidney cells, typically affecting one kidney but occasionally bilateral.

How it's Diagnosed: videos
Imaging studies (ultrasound, CT, MRI), biopsy or surgical removal of the tumor for histopathological examination, and blood/urine tests.

Treatment:
Surgery (nephrectomy), chemotherapy, and in some cases, radiation therapy.

Medications:
Chemotherapy agents include actinomycin D (antitumor antibiotic), vincristine (microtubule inhibitor), and doxorubicin (anthracycline).

Prevalence: How common the health condition is within a specific population.
Occurs in approximately 1 in 10,000 children, most commonly diagnosed in children aged 3 to 4 years.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Genetic syndromes (e.g., WAGR syndrome, Beckwith-Wiedemann syndrome, Denys-Drash syndrome), family history of Wilms' tumor, and certain congenital abnormalities.

Prognosis: The expected outcome or course of the condition over time.
Favorable in most cases; 5-year survival rates exceed 90% with prompt and appropriate treatment.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Complications include metastasis (commonly to the lungs), kidney dysfunction, recurrence, and long-term effects of chemotherapy or radiation.

Food allergies

Specialty: Pediatrics

Category: Immunologic and Rheumatologic Disorders

Sub-category: Allergic Disorders

Symptoms:
hives; swelling of lips, face, tongue, or throat; difficulty breathing; vomiting; diarrhea; abdominal pain; anaphylaxis (severe, life-threatening allergic reaction)

Root Cause:
The immune system mistakenly identifies certain proteins in food as harmful and releases chemicals like histamine to protect the body, triggering an allergic reaction.

How it's Diagnosed: videos
Diagnosis typically involves a detailed medical history, skin prick tests, blood tests for allergen-specific IgE antibodies, and food challenge tests under medical supervision.

Treatment:
The main treatment is avoiding the allergenic food. In case of accidental exposure, antihistamines can be used for mild reactions, while epinephrine (adrenaline) is prescribed for severe reactions or anaphylaxis.

Medications:
Common medications include antihistamines (e.g., cetirizine , loratadine , which are antihistamines used to reduce allergic reactions) and epinephrine (e.g., epinephrine auto-injectors like EpiPen or Auvi-Q for emergency treatment of anaphylaxis). Antihistamines are classified as H1 receptor antagonists, and epinephrine is a sympathomimetic drug.

Prevalence: How common the health condition is within a specific population.
Food allergies affect about 8% of children, with some studies showing a growing trend in allergic reactions, especially to peanuts, eggs, milk, and shellfish.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Family history of allergies, other allergic conditions (e.g., eczema or allergic rhinitis), early exposure to allergens, and living in urban areas with less exposure to diverse environmental microbes.

Prognosis: The expected outcome or course of the condition over time.
Many children outgrow food allergies as they age, though some food allergies (e.g., peanuts, tree nuts, fish, and shellfish) tend to persist into adulthood.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Anaphylaxis, which can be fatal if untreated, chronic allergic reactions leading to eczema or other skin conditions, and the psychological impact of living with food restrictions.

Vasculitis (e.g., Henoch-Schönlein Purpura)

Specialty: Pediatrics

Category: Immunologic and Rheumatologic Disorders

Sub-category: Autoimmune Disorders

Symptoms:
purple spots on the skin (purpura); abdominal pain; joint pain; kidney involvement (hematuria); vomiting; diarrhea

Root Cause:
Vasculitis in Henoch-Schönlein purpura (HSP) occurs when the body's immune system mistakenly attacks small blood vessels, leading to inflammation and leakage of blood into the skin and other organs.

How it's Diagnosed: videos
Diagnosis is based on clinical presentation (rash, joint pain, abdominal symptoms) and laboratory tests (e.g., urine analysis for kidney involvement, elevated ESR/CRP).

Treatment:
Treatment is typically supportive, including NSAIDs for joint pain and corticosteroids for more severe cases or to prevent kidney damage.

Medications:
NSAIDs (e.g., ibuprofen ) for pain and inflammation, corticosteroids (such as prednisone ) for more severe symptoms or kidney involvement.

Prevalence: How common the health condition is within a specific population.
HSP is the most common form of vasculitis in children, with an incidence of 10-20 per 100,000 children per year.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Typically follows an upper respiratory infection (e.g., streptococcal infection), genetic predisposition.

Prognosis: The expected outcome or course of the condition over time.
Most children recover fully without long-term consequences; however, kidney damage can occur in a small percentage, leading to chronic kidney disease.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Kidney involvement (e.g., glomerulonephritis), gastrointestinal bleeding, and long-term joint pain.

Urinary tract infections (UTIs)

Specialty: Pediatrics

Category: Miscellaneous Conditions

Sub-category: Renal and Urologic Disorders

Symptoms:
pain or burning during urination; frequent urination; urgent need to urinate; cloudy or foul-smelling urine; fever; abdominal pain; bedwetting in children; irritability in infants

Root Cause:
Caused by bacterial infections, most commonly Escherichia coli, entering the urinary tract and proliferating.

How it's Diagnosed: videos
Diagnosed through a urinalysis (checking for white blood cells, nitrites, or bacteria in urine) and urine culture to identify the causative organism.

Treatment:
Antibiotics are prescribed based on the sensitivity of the causative bacteria. Increased fluid intake and pain relievers may be recommended.

Medications:
Antibiotics such as amoxicillin-clavulanate, cephalexin (cephalosporins), or trimethoprim-sulfamethoxazole (sulfonamide class) are commonly prescribed. In more severe cases, intravenous antibiotics like ceftriaxone (third-generation cephalosporin) may be used.

Prevalence: How common the health condition is within a specific population.
Affects about 3–5% of children annually; more common in girls than boys after the neonatal period.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Female anatomy, improper wiping, constipation, urinary stasis, previous UTI, and vesicoureteral reflux (VUR).

Prognosis: The expected outcome or course of the condition over time.
Excellent with timely treatment; most children recover completely without complications.

Complications: Additional problems or conditions that may arise as a result of the original condition.
If untreated, can lead to kidney infection (pyelonephritis), sepsis, or long-term kidney damage such as scarring.

Wilms’ tumor

Specialty: Pediatrics

Category: Miscellaneous Conditions

Sub-category: Renal and Urologic Disorders

Symptoms:
abdominal swelling or mass; abdominal pain; fever; blood in the urine (hematuria); nausea or vomiting; loss of appetite; high blood pressure

Root Cause:
A rare kidney cancer arising from embryonic kidney cells, often associated with genetic mutations or syndromes like WAGR syndrome or Beckwith-Wiedemann syndrome.

How it's Diagnosed: videos
Diagnosed using imaging (abdominal ultrasound, CT, or MRI), blood tests, urinalysis, and biopsy to confirm the diagnosis.

Treatment:
Treatment includes surgery to remove the tumor (nephrectomy), followed by chemotherapy and sometimes radiation therapy.

Medications:
Chemotherapy drugs such as vincristine , dactinomycin , and doxorubicin are commonly used in combination.

Prevalence: How common the health condition is within a specific population.
Affects approximately 1 in 10,000 children, typically diagnosed between ages 3–4 years.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Family history of Wilms’ tumor, genetic syndromes (e.g., Beckwith-Wiedemann), and congenital anomalies like aniridia.

Prognosis: The expected outcome or course of the condition over time.
Prognosis is excellent with early diagnosis and treatment; 5-year survival rates exceed 90%.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Potential for metastasis (to lungs or liver), chronic kidney disease post-treatment, and complications from chemotherapy or radiation.

Internal Bleeding

Specialty: Emergency and Urgent Care

Category: Trauma and Injuries

Sub-category: Internal Organ Trauma

Symptoms:
abdominal pain; swelling; pallor; dizziness; fainting; rapid heartbeat; low blood pressure

Root Cause:
Damage to blood vessels or organs resulting in bleeding within the body, often due to trauma or rupture of blood vessels.

How it's Diagnosed: videos
Imaging studies (ultrasound, CT scan), blood tests (hemoglobin/hematocrit), and clinical signs.

Treatment:
Stabilization, fluid resuscitation, blood transfusions, and surgical intervention to stop bleeding.

Medications:
Antifibrinolytics (e.g., tranexamic acid) in certain trauma cases.

Prevalence: How common the health condition is within a specific population.
Common in severe trauma cases and certain medical conditions (e.g., aortic aneurysm rupture).

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
High-impact trauma, anticoagulant therapy, and coagulopathies.

Prognosis: The expected outcome or course of the condition over time.
Depends on the source and volume of bleeding; timely treatment is crucial.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Hemorrhagic shock, organ failure, and death if untreated.

Intestinal Obstruction

Specialty: Gastrointestinal

Category: Small Intestine Disorders

Sub-category: Structural Disorders

Symptoms:
abdominal pain; bloating; nausea and vomiting; inability to pass stool or gas; abdominal distension

Root Cause:
Partial or complete blockage of the intestinal lumen, caused by adhesions, tumors, hernias, or impacted stool.

How it's Diagnosed: videos
Clinical examination, abdominal X-rays, CT scan, ultrasound, and blood tests to check for dehydration or infection.

Treatment:
Non-surgical management includes IV fluids, nasogastric tube decompression, and bowel rest; surgery is required for complete obstructions, strangulation, or ischemia.

Medications:
Pain management with opioids (e.g., morphine ), antiemetics for nausea (e.g., ondansetron ), and antibiotics (e.g., metronidazole , ceftriaxone ) if infection or peritonitis is suspected.

Prevalence: How common the health condition is within a specific population.
Accounts for 20% of emergency hospital admissions for acute abdominal pain.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Prior abdominal or pelvic surgery, intestinal adhesions, hernias, tumors, and inflammatory bowel diseases.

Prognosis: The expected outcome or course of the condition over time.
Good with timely treatment, but delayed management can result in bowel ischemia, perforation, and sepsis.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Bowel ischemia, perforation, sepsis, and death if left untreated.

Upper GI Bleed (e.g., Variceal Bleed, Peptic Ulcer)

Specialty: Emergency and Urgent Care

Category: Gastrointestinal Emergencies

Sub-category: Gastrointestinal Bleeding

Symptoms:
hematemesis (vomiting blood); melena (black, tarry stools); abdominal pain; lightheadedness; pallor; fatigue; shock in severe cases

Root Cause:
Bleeding from the upper gastrointestinal tract, often due to peptic ulcers, varices, or tears in the esophageal lining (Mallory-Weiss tears).

How it's Diagnosed: videos
Endoscopy (gold standard), blood tests (CBC, coagulation profile), nasogastric lavage, imaging (if needed).

Treatment:
Resuscitation with fluids/blood products, endoscopic interventions (e.g., banding, sclerotherapy), pharmacologic therapy to reduce bleeding, and surgical interventions in refractory cases.

Medications:
Proton pump inhibitors (e.g., pantoprazole ) to reduce stomach acid; octreotide or vasopressin for variceal bleeding; antibiotics (e.g., ceftriaxone ) in variceal bleeding to prevent infections; hemostatic agents such as tranexamic acid (if indicated).

Prevalence: How common the health condition is within a specific population.
Approximately 50-150 cases per 100,000 people annually; more common in older adults.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Helicobacter pylori infection, NSAID use, alcohol abuse, liver cirrhosis, anticoagulant or antiplatelet use, smoking.

Prognosis: The expected outcome or course of the condition over time.
Varies depending on the cause and severity; high success rate with early intervention but increased mortality in severe cases or with comorbidities.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Hypovolemic shock, rebleeding, aspiration, multiorgan failure, death.

Diabetic ketoacidosis (DKA)

Specialty: Emergency and Urgent Care

Category: Endocrine and Metabolic Emergencies

Sub-category: Diabetes-Related Emergencies

Symptoms:
nausea; vomiting; abdominal pain; rapid breathing; fruity-scented breath; confusion; excessive thirst; frequent urination

Root Cause:
DKA occurs due to insufficient insulin, leading to uncontrolled hyperglycemia, ketone production, and metabolic acidosis.

How it's Diagnosed: videos
Clinical evaluation, laboratory tests showing hyperglycemia (blood glucose >250 mg/dL), ketonemia, ketonuria, low bicarbonate levels (<18 mEq/L), and an elevated anion gap metabolic acidosis.

Treatment:
Immediate fluid resuscitation (IV fluids), insulin therapy, electrolyte replacement (especially potassium), and addressing precipitating factors (e.g., infections).

Medications:
Regular insulin (short-acting insulin for IV infusion to lower blood glucose and suppress ketone production), potassium supplements (for electrolyte correction), bicarbonate (in severe acidosis cases, though used cautiously).

Prevalence: How common the health condition is within a specific population.
Common in individuals with type 1 diabetes and occasionally in type 2 diabetes under stress or illness.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Poor diabetes management, infections, physical or emotional stress, skipping insulin doses, undiagnosed diabetes.

Prognosis: The expected outcome or course of the condition over time.
Favorable if treated promptly; mortality is low with appropriate intervention but rises if untreated.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Cerebral edema (especially in children), hypokalemia, cardiac arrhythmias, hypoglycemia, and multi-organ failure in severe cases.

Testicular Torsion

Specialty: Emergency and Urgent Care

Category: Renal and Urologic Emergencies

Sub-category: Urologic Conditions

Symptoms:
sudden, severe testicular pain; swelling in the scrotum; abdominal pain; nausea and vomiting; high-riding testicle

Root Cause:
Twisting of the spermatic cord, cutting off blood supply to the testicle, often due to inadequate fixation of the testicle in the scrotum.

How it's Diagnosed: videos
Clinical exam (e.g., absence of cremasteric reflex), scrotal ultrasound with Doppler for blood flow assessment, and surgical exploration.

Treatment:
Immediate surgical detorsion and fixation (orchidopexy); removal (orchiectomy) if testicle is nonviable.

Medications:
Pain management (e.g., NSAIDs or acetaminophen ); antibiotics if infection coexists but typically not primary treatment.

Prevalence: How common the health condition is within a specific population.
Most common in males aged 12–18 but can occur at any age, including neonates.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Bell-clapper deformity, trauma, or sudden testicular movement.

Prognosis: The expected outcome or course of the condition over time.
Excellent if treated within 6 hours; testicular viability decreases significantly after 12 hours.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Testicular necrosis, infertility, and psychological distress.

Acetaminophen overdose

Specialty: Emergency and Urgent Care

Category: Toxicology and Overdose

Sub-category: Drug Overdoses

Symptoms:
nausea; vomiting; abdominal pain; confusion; jaundice (late stage); elevated liver enzymes

Root Cause:
Excessive acetaminophen overwhelms the liver's ability to conjugate and detoxify NAPQI (toxic metabolite), causing hepatocellular damage.

How it's Diagnosed: videos
History of overdose, serum acetaminophen levels, and liver function tests (LFTs); use of the Rumack-Matthew nomogram for risk assessment.

Treatment:
N-acetylcysteine (NAC) administration (oral or IV) to replenish glutathione, activated charcoal if within 1-2 hours of ingestion, and supportive care.

Medications:
N-acetylcysteine (antidote for acetaminophen toxicity) and activated charcoal (gastric decontaminant).

Prevalence: How common the health condition is within a specific population.
Acetaminophen toxicity is one of the most common causes of drug overdoses globally and a leading cause of acute liver failure in the U.S.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Chronic acetaminophen use, concurrent alcohol consumption, pre-existing liver disease, and taking higher-than-recommended doses.

Prognosis: The expected outcome or course of the condition over time.
Good with early treatment; delayed treatment increases the risk of liver failure, necessitating a liver transplant.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Acute liver failure, metabolic acidosis, encephalopathy, and death.

Spider Bites - Black Widow

Specialty: Emergency and Urgent Care

Category: Toxicology and Overdose

Sub-category: Envenomations

Symptoms:
severe muscle cramps; abdominal pain; sweating; high blood pressure; restlessness

Root Cause:
Spider venom contains toxins that affect the nervous system (black widow) or cause local tissue destruction and systemic inflammation (brown recluse).

How it's Diagnosed: videos
Clinical history, observation of the bite area, identification of the spider (if possible), and symptom correlation.

Treatment:
Wound care, supportive care, muscle relaxants for black widow bites, and possibly antivenom. Surgical debridement may be needed for necrotic wounds.

Medications:
Antivenom

Prevalence: How common the health condition is within a specific population.
Exact prevalence unknown; bites are more common in specific geographic areas where these spiders are endemic.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Working in or near woodpiles, attics, or basements; outdoor activities; handling debris.

Prognosis: The expected outcome or course of the condition over time.
Typically good with prompt treatment; severe complications are rare but may include long-term tissue damage.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Systemic toxicity (black widow), extensive necrosis (brown recluse), secondary infections.

Esophageal or Gastrointestinal Obstruction

Specialty: Emergency and Urgent Care

Category: Miscellaneous Emergencies

Sub-category: Foreign Body Ingestion/Inhalation

Symptoms:
difficulty swallowing (dysphagia); chest pain; drooling; regurgitation; vomiting; abdominal pain; inability to pass gas or stool (in cases of complete obstruction)

Root Cause:
A blockage in the esophagus or gastrointestinal tract caused by ingested foreign objects, strictures, tumors, or impacted food.

How it's Diagnosed: videos
Clinical history, physical examination, imaging studies (X-ray, CT scan, or ultrasound), endoscopy for direct visualization. Contrast studies may be used in some cases.

Treatment:
Removal of the obstruction via endoscopy, surgery for severe cases, and supportive care such as IV fluids or pain management. If caused by food impaction, smooth muscle relaxants or enzymatic agents may be used.

Medications:
Glucagon - Smooth muscle relaxant to assist with food impaction. Proton pump inhibitors (e.g., omeprazole ) - Reduce acid and prevent mucosal damage in prolonged obstructions. Antiemetics (e.g., ondansetron ) - To control vomiting during treatment.

Prevalence: How common the health condition is within a specific population.
Common among young children (due to foreign object ingestion) and adults with esophageal disorders such as strictures or motility issues.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Age (young children and elderly), neurological disorders, dental issues, alcohol intoxication, and eating too quickly.

Prognosis: The expected outcome or course of the condition over time.
Good if treated promptly; delayed intervention can result in perforation, infection, or permanent damage to the gastrointestinal tract.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Perforation, infection (mediastinitis or peritonitis), aspiration pneumonia, esophageal stricture formation, or death in severe cases.

Lymphangioleiomyomatosis (LAM)

Specialty: Pulmonology

Category: Restrictive Lung Diseases

Sub-category: Interstitial Lung Diseases (ILD)

Symptoms:
shortness of breath; chest pain; cough; fatigue; pneumothorax; hemoptysis; abdominal pain

Root Cause:
Abnormal growth of smooth muscle cells in the lungs and lymphatic system, leading to cystic destruction of the lung tissue and airway obstruction. Most common in women of reproductive age and often associated with tuberous sclerosis complex.

How it's Diagnosed: videos
HRCT showing characteristic cystic lesions, pulmonary function tests showing restrictive lung pattern, and genetic testing for tuberous sclerosis (if suspected).

Treatment:
No definitive cure; treatment focuses on symptom management, including oxygen therapy and management of pneumothorax. In some cases, lung transplantation may be considered.

Medications:
Rapamycin (sirolimus ), an immunosuppressant, may be used to slow disease progression, particularly in tuberous sclerosis-associated LAM.

Prevalence: How common the health condition is within a specific population.
Rare; affects about 1-2 women per 1,000,000 annually.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Genetic predisposition, specifically in individuals with tuberous sclerosis complex.

Prognosis: The expected outcome or course of the condition over time.
Progressive with variable severity; lung transplantation may be necessary in advanced cases.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Pneumothorax, pulmonary hypertension, respiratory failure, and renal tumors associated with tuberous sclerosis.

Polyarteritis Nodasa

Specialty: Cardiovascular

Category: Vascular Diseases

Sub-category: Vasculitis

Symptoms:
fever; weight loss; abdominal pain; muscle aches; skin rashes; neuropathy; hypertension

Root Cause:
Necrotizing vasculitis affecting medium-sized arteries, leading to tissue ischemia and organ damage.

How it's Diagnosed: videos
Biopsy of affected tissue; angiography; elevated ESR/CRP; hepatitis B serology (associated in some cases)

Treatment:
Corticosteroids and immunosuppressive drugs for inflammation control. Treat underlying hepatitis B if present.

Medications:
Prednisone (corticosteroid), cyclophosphamide (immunosuppressant), and antiviral therapy if hepatitis B is involved.

Prevalence: How common the health condition is within a specific population.
Incidence is 2–9 per million annually; more common in men aged 40–60 years.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Hepatitis B infection; male sex; middle age

Prognosis: The expected outcome or course of the condition over time.
Can be life-threatening without treatment but good with early intervention.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Renal failure; intestinal perforation; stroke; peripheral neuropathy

Primary (Addison’s Disease)

Specialty: Diabetes and Endocrinology

Category: Adrenal Disorders

Sub-category: Adrenal Insufficiency

Symptoms:
fatigue; weight loss; muscle weakness; low blood pressure; salt cravings; hyperpigmentation of the skin; nausea; vomiting; abdominal pain; hypoglycemia

Root Cause:
Destruction or dysfunction of the adrenal cortex leads to insufficient production of cortisol and, often, aldosterone.

How it's Diagnosed: videos
Diagnosis involves clinical evaluation, blood tests showing low cortisol and high ACTH levels, and confirmation with an ACTH stimulation test. Electrolyte imbalances (e.g., hyponatremia, hyperkalemia) and low aldosterone may also be observed.

Treatment:
Lifelong hormone replacement therapy with glucocorticoids and mineralocorticoids, stress management, and patient education on managing adrenal crises.

Medications:
Medications include hydrocortisone or prednisone (glucocorticoids) to replace cortisol and fludrocortisone (a mineralocorticoid) to replace aldosterone. These are classified as corticosteroid replacement therapies.

Prevalence: How common the health condition is within a specific population.
Rare; approximately 1 in 100,000 people are affected, with equal distribution across genders.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Autoimmune diseases (e.g., autoimmune polyendocrine syndrome), infections (e.g., tuberculosis), adrenal hemorrhage, or genetic predisposition.

Prognosis: The expected outcome or course of the condition over time.
With proper treatment, individuals can live normal lives, but they must manage the risk of adrenal crises, especially during stress or illness.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Adrenal crisis (life-threatening), severe hypotension, electrolyte imbalances, and hypoglycemia.

Adrenal Adenomas (Functional and Non-Functional)

Specialty: Diabetes and Endocrinology

Category: Adrenal Disorders

Sub-category: Adrenal Tumors

Symptoms:
abdominal pain; unexplained weight gain or loss; hypertension; fatigue; weakness; hormonal imbalances such as excess cortisol, aldosterone, or androgens (in functional adenomas); asymptomatic (in non-functional adenomas)

Root Cause:
Benign tumors in the adrenal gland, which may or may not produce excess hormones, leading to varied clinical presentations.

How it's Diagnosed: videos
Blood and urine tests for hormone levels, imaging studies such as CT or MRI to identify the size and location of the adenoma, and adrenal vein sampling in specific cases.

Treatment:
Treatment depends on whether the adenoma is functional or non-functional. Functional adenomas typically require surgical removal, whereas non-functional adenomas may be monitored for growth and changes.

Medications:
Medications to manage symptoms include antihypertensives for blood pressure control, spironolactone for aldosterone-related issues, and ketoconazole or metyrapone to reduce cortisol production in Cushing’s syndrome. These medications are classified as antihypertensives, mineralocorticoid receptor antagonists, and steroidogenesis inhibitors, respectively.

Prevalence: How common the health condition is within a specific population.
Found in approximately 3–5% of adults, with prevalence increasing with age.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Older age, obesity, hypertension, and family history of adrenal tumors or hormone disorders.

Prognosis: The expected outcome or course of the condition over time.
Generally good if the adenomas are treated or monitored appropriately; functional adenomas can lead to complications if untreated.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Potential complications include Cushing's syndrome, primary aldosteronism, metabolic syndrome, cardiovascular diseases, or malignant transformation (rare).

Adrenal Carcinoma

Specialty: Diabetes and Endocrinology

Category: Adrenal Disorders

Sub-category: Adrenal Tumors

Symptoms:
abdominal pain; unexplained weight loss; hypertension; virilization or feminization (due to androgen or estrogen secretion); cushingoid features (from excess cortisol); weakness; palpable abdominal mass

Root Cause:
A rare and aggressive cancer arising from the adrenal cortex, often associated with excess production of adrenal hormones.

How it's Diagnosed: videos
Blood and urine tests to assess hormone secretion, imaging studies like CT or MRI to identify tumor size and spread, and biopsy or surgical pathology for definitive diagnosis.

Treatment:
Treatment often involves surgical removal of the tumor (adrenalectomy), radiation therapy, and chemotherapy, depending on the stage and spread.

Medications:
Mitotane , an adrenalytic agent, is commonly used to reduce hormone production and target cancer cells. Additional chemotherapy agents include etoposide , doxorubicin , and cisplatin .

Prevalence: How common the health condition is within a specific population.
Extremely rare, with an incidence of 1–2 cases per million annually.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Genetic syndromes such as Li-Fraumeni syndrome, Beckwith-Wiedemann syndrome, and MEN1; family history of adrenal cancers; and certain environmental exposures.

Prognosis: The expected outcome or course of the condition over time.
Variable; early-stage tumors have a better prognosis, with a 5-year survival rate of approximately 50–60%. Advanced-stage adrenal carcinoma has a much poorer prognosis.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Metastasis to other organs (lungs, liver, or bones), severe hormonal imbalances, and recurrence after treatment.

Somatostatinoma

Specialty: Diabetes and Endocrinology

Category: Pancreatic Endocrine Disorders

Symptoms:
diabetes; gallstones; steatorrhea (fatty stools); abdominal pain; weight loss; diarrhea; nausea

Root Cause:
Overproduction of somatostatin, usually due to a rare neuroendocrine tumor in the pancreas or duodenum, leading to inhibition of other hormone secretions.

How it's Diagnosed: videos
Blood tests (elevated somatostatin levels), imaging studies (CT, MRI, or octreotide scans), and biopsy of the tumor.

Treatment:
Surgical resection of the tumor, somatostatin analogs for symptom control, and supportive therapy for nutritional issues.

Medications:
Somatostatin analogs such as octreotide or lanreotide may be used to manage symptoms.

Prevalence: How common the health condition is within a specific population.
Extremely rare; incidence is estimated to be less than 1 per million people annually.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Often sporadic but may be associated with genetic syndromes like MEN1 or von Hippel-Lindau disease.

Prognosis: The expected outcome or course of the condition over time.
Variable; early detection and treatment improve outcomes, but metastatic disease has a poor prognosis.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Metastasis, severe malnutrition due to malabsorption, and hormonal imbalances.

MEN Type 1 - Hypercalcemia

Specialty: Diabetes and Endocrinology

Category: Rare Endocrine Disorders

Sub-category: Multiple Endocrine Neoplasia (MEN) Syndromes

Symptoms:
fatigue; kidney stones; bone pain; abdominal pain

Root Cause:
Genetic mutation in the MEN1 gene leads to tumor formation in endocrine glands (parathyroid, pituitary, pancreas).

How it's Diagnosed: videos
Genetic testing for MEN1 mutation. Hormonal blood tests (calcium, PTH, prolactin, growth hormone, insulin). Imaging studies (MRI or CT scans of the pituitary, pancreas, and parathyroid glands).

Treatment:
Surgical removal of tumors (e.g., parathyroidectomy, pituitary surgery). Medical management for hormone overproduction (e.g., somatostatin analogs for pancreatic tumors). Regular monitoring for tumor progression.

Medications:
Calcimimetics (e.g., cinacalcet ) for hyperparathyroidism. Dopamine agonists (e.g., cabergoline , bromocriptine ) for prolactinomas. Somatostatin analogs (e.g., octreotide , lanreotide ) for pancreatic neuroendocrine tumors. Proton pump inhibitors (e.g., omeprazole ) for gastrinomas.

Prevalence: How common the health condition is within a specific population.
Approximately 1 in 30,000 individuals worldwide.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Family history of MEN1 syndrome, autosomal dominant inheritance.

Prognosis: The expected outcome or course of the condition over time.
Generally good with early detection and treatment, though tumor recurrence is possible; life expectancy may be reduced without management.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Recurrent or metastatic tumors. Severe hypercalcemia leading to kidney damage. Hormonal crises, such as insulinoma-induced hypoglycemia.

Gastritis (Acute and Chronic)

Specialty: Gastrointestinal

Category: Stomach Disorders

Sub-category: Inflammatory Disorders

Symptoms:
abdominal pain; nausea; vomiting; loss of appetite; bloating; belching; indigestion; dark stools (if bleeding occurs)

Root Cause:
Inflammation of the stomach lining caused by factors such as Helicobacter pylori infection, excessive alcohol consumption, NSAID use, or autoimmune disorders.

How it's Diagnosed: videos
Through patient history, physical examination, endoscopy with biopsy, and testing for H. pylori (urea breath test, stool antigen test, or blood antibody test).

Treatment:
Addressing the underlying cause (e.g., H. pylori eradication, reducing NSAID use), lifestyle modifications, and symptomatic relief.

Medications:
Proton pump inhibitors (PPIs) like omeprazole or lansoprazole to reduce stomach acid. H2-receptor antagonists such as ranitidine or famotidine to reduce acid production. Antibiotics (if H. pylori is present) like amoxicillin , clarithromycin , and metronidazole for bacterial eradication. Antacids for temporary relief of symptoms.

Prevalence: How common the health condition is within a specific population.
Common worldwide; chronic gastritis is prevalent in up to 50% of the global population, with higher rates in developing countries due to H. pylori.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Chronic H. pylori infection, long-term NSAID use, excessive alcohol intake, smoking, stress, autoimmune conditions, older age.

Prognosis: The expected outcome or course of the condition over time.
Good with appropriate treatment; acute cases often resolve quickly, while chronic cases require ongoing management to prevent complications.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Peptic ulcers, gastric bleeding, anemia, increased risk of gastric cancer (especially in chronic cases linked to H. pylori).

Gastroparesis (Delayed Gastric Emptying)

Specialty: Gastrointestinal

Category: Stomach Disorders

Sub-category: Structural and Functional Disorders

Symptoms:
nausea; vomiting; bloating; early satiety; abdominal pain; unintentional weight loss; heartburn

Root Cause:
Impaired motility of the stomach muscles prevents proper emptying of stomach contents into the small intestine, often associated with vagus nerve damage or autonomic dysfunction.

How it's Diagnosed: videos
Diagnosed through gastric emptying studies (scintigraphy), upper gastrointestinal (GI) endoscopy to rule out obstruction, and breath tests (e.g., carbon-labeled meal breath test).

Treatment:
Dietary changes (small, low-fat meals), medications to improve gastric motility, and in severe cases, gastric electrical stimulation or feeding tubes.

Medications:
Metoclopramide (dopamine antagonist) is often prescribed to improve stomach contractions. Domperidone (dopamine antagonist) is another option available in some regions. Erythromycin (macrolide antibiotic) can enhance gastric motility as a side effect. Antiemetics such as ondansetron or promethazine may be used to manage nausea.

Prevalence: How common the health condition is within a specific population.
Affects approximately 0.2% of the general population; higher prevalence among individuals with diabetes or post-surgical complications.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Diabetes mellitus, prior gastric surgery, systemic diseases like scleroderma, infections, and certain medications (e.g., opioids, anticholinergics).

Prognosis: The expected outcome or course of the condition over time.
Varies; many cases improve with dietary changes and medications, but severe cases may lead to malnutrition and require surgical interventions.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Malnutrition, dehydration, bezoars (hardened masses of undigested food), and severe weight loss.

Gastric Adenocarcinoma

Specialty: Gastrointestinal

Category: Stomach Disorders

Sub-category: Stomach Cancer

Symptoms:
abdominal pain; unexplained weight loss; nausea; vomiting; loss of appetite; early satiety; blood in stool; fatigue

Root Cause:
Malignant transformation of the gastric mucosal cells, often associated with chronic inflammation, H. pylori infection, genetic predisposition, or dietary carcinogens.

How it's Diagnosed: videos
Endoscopy with biopsy, imaging studies (CT scan, MRI, PET), blood tests for tumor markers (e.g., CEA, CA 19-9), and staging procedures.

Treatment:
Surgical resection (gastrectomy), chemotherapy, radiation therapy, targeted therapy (e.g., HER2 inhibitors for HER2-positive tumors).

Medications:
Treatment may include chemotherapy drugs such as 5-fluorouracil (5-FU) (antimetabolite), cisplatin (platinum-based alkylating agent), and trastuzumab (HER2-targeted monoclonal antibody) for HER2-positive cases.

Prevalence: How common the health condition is within a specific population.
One of the most common types of stomach cancer, with higher rates in East Asia, Eastern Europe, and South America.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
H. pylori infection, smoking, high salt intake, diet low in fruits and vegetables, chronic gastritis, family history of gastric cancer, genetic syndromes (e.g., Lynch syndrome).

Prognosis: The expected outcome or course of the condition over time.
Prognosis depends on the stage at diagnosis; early detection improves survival rates significantly, but advanced cases have poorer outcomes.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Metastasis to other organs (liver, lungs, peritoneum), gastrointestinal bleeding, obstruction, and malnutrition.

Gastrointestinal Stromal Tumors (GISTs)

Specialty: Gastrointestinal

Category: Stomach Disorders

Sub-category: Stomach Tumors

Symptoms:
abdominal pain; gastrointestinal bleeding; early satiety; nausea; vomiting; unexplained weight loss

Root Cause:
Tumors arising from the interstitial cells of Cajal in the gastrointestinal tract, often due to mutations in the KIT or PDGFRA genes.

How it's Diagnosed: videos
Endoscopy, biopsy with immunohistochemistry (testing for KIT/CD117 positivity), CT scan, MRI, and PET scan for staging.

Treatment:
Surgical resection for localized tumors, tyrosine kinase inhibitors (TKIs) like imatinib for advanced or metastatic cases.

Medications:
Imatinib (a tyrosine kinase inhibitor) is the first-line treatment for advanced or metastatic GISTs. Other options include sunitinib and regorafenib for imatinib-resistant cases.

Prevalence: How common the health condition is within a specific population.
Relatively rare, accounting for less than 1% of gastrointestinal cancers, with a higher incidence in adults over 50.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Family history of GISTs, genetic mutations, age over 50, and association with neurofibromatosis type 1 (NF1).

Prognosis: The expected outcome or course of the condition over time.
Excellent prognosis for localized GISTs treated surgically; variable outcomes for advanced cases depending on response to TKI therapy.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Tumor rupture, peritoneal spread, liver metastases, and gastrointestinal obstruction or perforation.

Lymphoma of the Stomach

Specialty: Gastrointestinal

Category: Stomach Disorders

Sub-category: Stomach Lymphomas

Symptoms:
abdominal pain; bloating; weight loss; nausea; vomiting; fatigue; fever; night sweats; loss of appetite

Root Cause:
Malignant proliferation of lymphoid tissue in the stomach, often linked to chronic H. pylori infection or immune suppression.

How it's Diagnosed: videos
Endoscopy with biopsy, histopathology, immunohistochemistry, imaging (CT, PET scan), and bone marrow biopsy for staging.

Treatment:
Eradication of H. pylori with antibiotics if associated, chemotherapy, radiation therapy, immunotherapy (e.g., rituximab), or a combination depending on the lymphoma type.

Medications:
Antibiotics (for H. pylori-associated cases, e.g., amoxicillin and clarithromycin ), rituximab (CD20 monoclonal antibody), and chemotherapy agents like cyclophosphamide , doxorubicin , vincristine , and prednisone (CHOP regimen).

Prevalence: How common the health condition is within a specific population.
Represents less than 5% of all stomach cancers, with a higher prevalence in individuals with chronic H. pylori infection.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
H. pylori infection, autoimmune disorders, immunosuppression, and family history of lymphoma.

Prognosis: The expected outcome or course of the condition over time.
Varies by type and stage; early-stage cases have a good prognosis, particularly with H. pylori eradication, while advanced cases depend on response to chemotherapy.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Gastrointestinal bleeding, obstruction, perforation, and spread to lymph nodes or other organs.

Zollinger-Ellison Syndrome (Gastrinoma)

Specialty: Gastrointestinal

Category: Other Stomach Conditions

Sub-category: Stomach Cancer

Symptoms:
abdominal pain; diarrhea; nausea; vomiting; weight loss; heartburn; gastric ulcers; gastrointestinal bleeding

Root Cause:
Excessive secretion of gastrin due to a gastrin-secreting tumor (gastrinoma), leading to increased stomach acid production.

How it's Diagnosed: videos
Blood tests to measure gastrin levels, secretin stimulation test, imaging studies (CT, MRI, or somatostatin receptor scintigraphy) to locate gastrinoma, and endoscopic examination.

Treatment:
Proton pump inhibitors (PPIs) to reduce acid production, surgical removal of the gastrinoma, and chemotherapy or targeted therapy for metastatic disease.

Medications:
Proton pump inhibitors (e.g., omeprazole or esomeprazole ) to reduce gastric acid secretion; somatostatin analogs (e.g., octreotide ) to inhibit gastrin release; chemotherapeutic agents (e.g., streptozocin and doxorubicin ) for advanced cases.

Prevalence: How common the health condition is within a specific population.
Rare; occurs in approximately 1–3 individuals per million annually.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Associated with multiple endocrine neoplasia type 1 (MEN1), family history of endocrine tumors.

Prognosis: The expected outcome or course of the condition over time.
Varies; curable if localized gastrinoma is surgically removed, but prognosis worsens with metastatic disease.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Peptic ulcers, perforation of the stomach or intestines, gastrointestinal bleeding, severe diarrhea, and malnutrition.

Lactose Intolerance

Specialty: Gastrointestinal

Category: Small Intestine Disorders

Sub-category: Malabsorption Syndromes

Symptoms:
diarrhea; bloating; gas; abdominal pain; nausea after consuming dairy products

Root Cause:
Insufficient production of lactase enzyme in the small intestine, leading to inability to digest lactose, a sugar found in milk and dairy products.

How it's Diagnosed: videos
Lactose tolerance test, hydrogen breath test, stool acidity test for infants and children.

Treatment:
Dietary management by avoiding lactose-containing foods or using lactase enzyme supplements.

Medications:
Lactase enzyme supplements (e.g., Lactaid) can help digest lactose.

Prevalence: How common the health condition is within a specific population.
Affects approximately 65% of the global population, with higher prevalence in Asian, African, and Native American populations.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Genetic predisposition, age-related decline in lactase production, gastrointestinal diseases (e.g., celiac disease, Crohn's disease) affecting the small intestine.

Prognosis: The expected outcome or course of the condition over time.
Excellent with appropriate dietary adjustments; symptoms resolve when lactose is avoided or enzymatically digested.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Nutritional deficiencies (e.g., calcium, vitamin D) if dairy products are not replaced with alternative sources.

Small Intestinal Bacterial Overgrowth (SIBO)

Specialty: Gastrointestinal

Category: Small Intestine Disorders

Sub-category: Digestive Disorders

Symptoms:
bloating; diarrhea; abdominal pain; flatulence; unintended weight loss; malnutrition symptoms like fatigue and anemia

Root Cause:
Excessive growth of bacteria in the small intestine, disrupting normal digestion and nutrient absorption. Often linked to motility disorders, structural abnormalities, or changes in gut flora.

How it's Diagnosed: videos
Diagnosed using breath tests (e.g., hydrogen/methane levels) or small bowel aspirate cultures.

Treatment:
Treated with dietary changes, probiotics, and antibiotics such as rifaximin or metronidazole.

Medications:
Antibiotics like rifaximin or metronidazole are commonly prescribed to reduce bacterial overgrowth. Prokinetics (e.g., erythromycin or prucalopride ) may be used to improve motility, and nutritional supplements are given for deficiencies.

Prevalence: How common the health condition is within a specific population.
Exact prevalence is unknown but more common in individuals with conditions like irritable bowel syndrome (IBS), diabetes, or previous gastrointestinal surgery.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Conditions that impair small intestinal motility (e.g., scleroderma, diabetes), anatomical abnormalities (e.g., diverticula), or previous surgery (e.g., gastric bypass).

Prognosis: The expected outcome or course of the condition over time.
Good with appropriate treatment; relapses are common if the underlying condition isn’t addressed.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Chronic malnutrition, fat-soluble vitamin deficiencies (A, D, E, K), osteoporosis, and small intestine damage if left untreated.

Meckel’s Diverticulum

Specialty: Gastrointestinal

Category: Small Intestine Disorders

Sub-category: Structural Disorders

Symptoms:
painless rectal bleeding; abdominal pain; intestinal obstruction; signs of anemia in chronic cases

Root Cause:
Congenital remnant of the omphalomesenteric duct, forming a small pouch in the small intestine that may harbor ectopic tissue (e.g., gastric or pancreatic).

How it's Diagnosed: videos
Meckel’s scan using technetium-99m, abdominal CT, MRI, or exploratory surgery.

Treatment:
Surgical resection (diverticulectomy or segmental bowel resection) if symptomatic.

Medications:
Post-surgical antibiotics (e.g., cefazolin , metronidazole ) to prevent infection, and pain management with acetaminophen or NSAIDs.

Prevalence: How common the health condition is within a specific population.
Present in 2% of the population; symptomatic cases are rare, occurring in approximately 4–6% of affected individuals.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Male sex, younger age (most symptomatic cases occur in children under 10), and ectopic tissue presence.

Prognosis: The expected outcome or course of the condition over time.
Excellent after surgical treatment; asymptomatic cases may remain undetected for life.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Intestinal obstruction, volvulus, perforation, and gastrointestinal bleeding.

Whipple’s Disease

Specialty: Gastrointestinal

Category: Small Intestine Disorders

Sub-category: Infectious Disorders

Symptoms:
chronic diarrhea; abdominal pain; weight loss; arthritis; fever; lymphadenopathy; neurological symptoms (e.g., cognitive changes)

Root Cause:
Caused by Tropheryma whipplei, a Gram-positive bacterium that affects the small intestine and other organs, leading to systemic inflammation and malabsorption.

How it's Diagnosed: videos
Small bowel biopsy showing periodic acid–Schiff (PAS)-positive macrophages, PCR testing for Tropheryma whipplei, and blood or cerebrospinal fluid tests if systemic involvement is suspected.

Treatment:
Long-term antibiotic therapy, starting with intravenous ceftriaxone or penicillin, followed by oral trimethoprim-sulfamethoxazole for 1–2 years.

Medications:
Ceftriaxone or penicillin (initial intravenous treatment) followed by trimethoprim-sulfamethoxazole (a sulfonamide combination for extended therapy).

Prevalence: How common the health condition is within a specific population.
Rare, affecting approximately 1–3 cases per million people annually, typically seen in middle-aged Caucasian males.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Unknown; may include genetic predisposition or environmental exposure.

Prognosis: The expected outcome or course of the condition over time.
Good if treated early; without treatment, the disease is usually fatal. Relapses are possible and require monitoring.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Systemic involvement affecting the heart (endocarditis), central nervous system, and joints, potentially leading to life-threatening outcomes if untreated.

Small Bowel Adenocarcinoma

Specialty: Gastrointestinal

Category: Small Intestine Disorders

Sub-category: Tumors

Symptoms:
abdominal pain; nausea; vomiting; unexplained weight loss; intestinal obstruction; anemia; blood in stool

Root Cause:
Uncontrolled growth of malignant epithelial cells originating in the small intestine, often due to genetic mutations or chronic inflammation.

How it's Diagnosed: videos
Imaging studies (CT scans, MRI, PET scans), endoscopy, biopsy, blood tests (including tumor markers like CEA or CA19-9).

Treatment:
Surgery to remove the tumor, chemotherapy, and in some cases, targeted therapy.

Medications:
Chemotherapy drugs such as 5-fluorouracil (antimetabolite), oxaliplatin (platinum-based agent), or capecitabine (oral antimetabolite). Targeted therapies like pembrolizumab (immune checkpoint inhibitor) may also be used.

Prevalence: How common the health condition is within a specific population.
Rare, accounting for approximately 3-5% of gastrointestinal cancers and less than 1% of all cancers.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Family history of gastrointestinal cancers, genetic syndromes (e.g., Lynch syndrome, familial adenomatous polyposis), chronic inflammation (e.g., Crohn’s disease), and diet high in red or processed meat.

Prognosis: The expected outcome or course of the condition over time.
Varies by stage; localized tumors have a better prognosis (5-year survival rate ~65%), while advanced/metastatic disease has a poor prognosis (~10-20% 5-year survival).

Complications: Additional problems or conditions that may arise as a result of the original condition.
Intestinal obstruction, perforation, metastasis to the liver or lymph nodes, and paraneoplastic syndromes.

Carcinoid Tumors

Specialty: Oncology

Category: Sarcomas

Sub-category: Rare Cancers

Symptoms:
flushing; diarrhea; abdominal pain; wheezing; heart valve problems; weight loss; fatigue

Root Cause:
Carcinoid tumors arise from neuroendocrine cells, which produce hormones such as serotonin and other chemicals. These tumors often grow slowly and can secrete hormones that affect various body systems.

How it's Diagnosed: videos
Diagnosis is typically through imaging studies such as CT scans, MRIs, or PET scans, and blood tests measuring elevated levels of serotonin or 5-HIAA (a serotonin metabolite). Biopsy and histopathological examination confirm the diagnosis.

Treatment:
Treatment may include surgery to remove the tumor, somatostatin analogs (like octreotide) to control symptoms, chemotherapy, and in some cases, liver-directed therapies (such as ablation or embolization) if the tumors have spread to the liver.

Medications:
Somatostatin analogs (e.g., octreotide and lanreotide ) are often prescribed to control symptoms and inhibit hormone secretion. These medications are classified as peptide receptor drugs and can help reduce flushing and diarrhea. Chemotherapy agents may also be used, depending on the tumor's progression, such as streptozocin and temozolomide , which are alkylating agents.

Prevalence: How common the health condition is within a specific population.
Carcinoid tumors are rare, accounting for about 0.5% of all cancers, but the incidence of neuroendocrine tumors is rising, with an estimated prevalence of 2-5 cases per 100,000 people per year.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Risk factors include age (more common in older adults), a family history of neuroendocrine tumors, certain inherited genetic syndromes (such as MEN1 and von Hippel-Lindau syndrome), and conditions that affect the gastrointestinal tract like Crohn's disease.

Prognosis: The expected outcome or course of the condition over time.
The prognosis depends on the location and spread of the tumor. Localized tumors have a relatively good prognosis with surgery, but metastatic or advanced cases can be more challenging to treat. The 5-year survival rate for localized carcinoid tumors is around 80%, while it drops significantly with distant metastases.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Potential complications include carcinoid syndrome (which leads to flushing, diarrhea, and heart valve problems), liver metastasis, and malnutrition due to nutrient malabsorption from the gastrointestinal symptoms.

Lymphoma of the Small Intestine

Specialty: Gastrointestinal

Category: Small Intestine Disorders

Sub-category: Tumors

Symptoms:
abdominal pain; nausea; weight loss; diarrhea; intestinal obstruction; fever; night sweats

Root Cause:
Malignant proliferation of lymphocytes in the small intestine, often associated with immune dysregulation or infections.

How it's Diagnosed: videos
Endoscopic biopsy, imaging (CT scans, PET scans), blood tests, bone marrow biopsy, and immunophenotyping.

Treatment:
Chemotherapy, radiation therapy, and immunotherapy; surgery may be required in some cases of localized disease.

Medications:
Chemotherapy agents like CHOP regimen (cyclophosphamide , doxorubicin , vincristine , prednisone ), and monoclonal antibodies such as rituximab (anti-CD20 agent).

Prevalence: How common the health condition is within a specific population.
Rare; accounts for 1-4% of gastrointestinal malignancies and 30-40% of primary gastrointestinal lymphomas.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Immunodeficiency (e.g., HIV/AIDS, post-transplant), chronic inflammatory diseases (e.g., celiac disease), and infections (e.g., Helicobacter pylori, Epstein-Barr virus).

Prognosis: The expected outcome or course of the condition over time.
Depends on subtype and stage; indolent types have a good prognosis (5-year survival rate ~80%), while aggressive types have lower survival rates (~30-50%).

Complications: Additional problems or conditions that may arise as a result of the original condition.
Intestinal perforation, obstruction, bleeding, malabsorption, and systemic spread to other lymphoid or non-lymphoid tissues.

Infectious Colitis (e.g., Viral, Bacterial, Parasitic)

Specialty: Gastrointestinal

Category: Large Intestine (Colon) Disorders

Sub-category: Infectious Disorders

Symptoms:
diarrhea (often with blood or mucus); abdominal pain; fever; nausea; vomiting; fatigue; dehydration; weight loss

Root Cause:
Infection of the colon by pathogens such as bacteria (e.g., Salmonella, Shigella, E. coli, Campylobacter), viruses (e.g., norovirus, rotavirus), or parasites (e.g., Entamoeba histolytica, Giardia). This leads to inflammation and damage to the intestinal lining.

How it's Diagnosed: videos
Stool tests for pathogens (culture, PCR, or antigen detection), blood tests for inflammatory markers, and colonoscopy in chronic or severe cases to assess mucosal damage.

Treatment:
Supportive care (hydration, electrolyte replacement) and pathogen-specific treatment. Antibiotics for bacterial infections, antiparasitic medications for parasitic infections, and sometimes antiviral therapy for severe viral infections.

Medications:
Antibiotics like ciprofloxacin or azithromycin for bacterial infections; metronidazole or tinidazole for parasitic infections like Giardia or Entamoeba; oral rehydration salts for dehydration. Antibiotics are categorized as antimicrobials, while antiparasitic drugs target protozoa.

Prevalence: How common the health condition is within a specific population.
Infectious colitis is a common cause of diarrhea worldwide, with bacterial pathogens accounting for 85% of foodborne outbreaks in developed countries.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Contaminated food or water, international travel, poor hygiene, immunosuppression, and exposure to infected individuals.

Prognosis: The expected outcome or course of the condition over time.
Most cases resolve within days to weeks with appropriate treatment, but severe infections can lead to prolonged illness or death, particularly in vulnerable populations.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Dehydration, electrolyte imbalances, hemolytic uremic syndrome (HUS, associated with E. coli O157:H7), chronic post-infectious irritable bowel syndrome, and intestinal perforation.

Viral Hepatitis (A, B, C, D, E)

Specialty: Gastrointestinal

Category: Liver Disorders

Sub-category: Hepatitis

Symptoms:
jaundice; fatigue; abdominal pain; nausea; vomiting; loss of appetite; dark urine; pale stools

Root Cause:
Infection of the liver caused by hepatitis viruses (A, B, C, D, or E), leading to liver inflammation and, in some cases, chronic liver disease.

How it's Diagnosed: videos
Blood tests to identify viral markers (e.g., HBsAg, anti-HCV, anti-HAV), liver function tests, imaging studies like ultrasound, and sometimes liver biopsy.

Treatment:
Treatment depends on the type of hepatitis. Includes antiviral medications, supportive care (hydration, rest), and, in severe cases, liver transplantation.

Medications:
Hepatitis B - Tenofovir (antiviral, nucleotide analog), Entecavir (antiviral, nucleoside analog). Hepatitis C - Sofosbuvir and Velpatasvir (direct-acting antiviral agents). Hepatitis A & E - No specific antiviral treatment; supportive care. Hepatitis D - Pegylated interferon-alpha (antiviral, immune modulator).

Prevalence: How common the health condition is within a specific population.
Affects millions globally; Hepatitis B and C are the most common chronic forms, with over 250 million and 70 million people affected worldwide, respectively.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Unprotected sex, intravenous drug use, sharing needles, blood transfusions, close contact with infected individuals, and poor sanitation.

Prognosis: The expected outcome or course of the condition over time.
Acute hepatitis often resolves with supportive care, but chronic hepatitis (especially B and C) can lead to cirrhosis, liver failure, or hepatocellular carcinoma if untreated.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Chronic liver disease, cirrhosis, liver cancer, and liver failure.

Alcoholic Hepatitis

Specialty: Infectious Diseases

Category: Gastrointestinal Tract and Intra-abdominal Infections

Symptoms:
jaundice; abdominal pain; nausea; vomiting; fever; weight loss; fatigue; anorexia

Root Cause:
Inflammation and liver cell damage caused by prolonged and excessive alcohol consumption leading to toxic metabolites.

How it's Diagnosed: videos
Clinical history of alcohol use, physical examination, liver function tests (elevated AST, ALT, and bilirubin levels), imaging (ultrasound/CT), and sometimes liver biopsy.

Treatment:
Cessation of alcohol, nutritional support, corticosteroids (for severe cases), and addressing complications like infections or ascites.

Medications:
Medications include corticosteroids (e.g., prednisolone ), which reduce inflammation; pentoxifylline , a phosphodiesterase inhibitor that may prevent complications like hepatorenal syndrome. Vitamin supplementation (e.g., thiamine and folate) is often provided for nutritional deficiencies.

Prevalence: How common the health condition is within a specific population.
Alcoholic hepatitis is most common in individuals with a history of chronic alcohol use, with a prevalence of approximately 1–2% of heavy drinkers annually.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Chronic heavy alcohol consumption, malnutrition, genetic predisposition, female gender (higher susceptibility), obesity, and prior liver disease.

Prognosis: The expected outcome or course of the condition over time.
Varies with severity; mild cases may recover with alcohol cessation, while severe cases have a high mortality rate without intervention.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Liver cirrhosis, portal hypertension, ascites, hepatic encephalopathy, and increased risk of infections.

Hepatocellular Carcinoma (HCC)

Specialty: Oncology

Category: Solid Tumors

Sub-category: Gastrointestinal Cancers

Symptoms:
abdominal pain; jaundice; fatigue; unexplained weight loss; swelling in the abdomen; loss of appetite

Root Cause:
Primary liver cancer arising from hepatocytes, often due to cirrhosis caused by chronic hepatitis B or C infection, or chronic liver damage.

How it's Diagnosed: videos
Imaging (CT scan, MRI, or ultrasound), AFP blood test, and liver biopsy in some cases.

Treatment:
Curative options include surgical resection or liver transplantation; other treatments include ablation, embolization, targeted therapy, and immunotherapy.

Medications:
Sorafenib and lenvatinib are first-line treatments; immunotherapy includes atezolizumab combined with bevacizumab . Regorafenib is used for advanced cases.

Prevalence: How common the health condition is within a specific population.
The most common primary liver cancer; accounts for about 75% of liver cancer cases globally.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Cirrhosis, hepatitis B or C infection, alcohol use, NAFLD, obesity, and diabetes.

Prognosis: The expected outcome or course of the condition over time.
Varies widely; 5-year survival rate is about 33% for localized cases but poor for advanced disease.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Liver failure, metastasis, and worsening cirrhosis.

Hemochromatosis

Specialty: Gastrointestinal

Category: Liver Disorders

Sub-category: Metabolic and Genetic Liver Disorders

Symptoms:
fatigue; joint pain; abdominal pain; bronze or gray skin discoloration; weakness; diabetes; irregular heartbeat; liver dysfunction

Root Cause:
Excessive iron absorption and accumulation in tissues due to a genetic mutation, typically in the HFE gene.

How it's Diagnosed: videos
Blood tests (serum ferritin, transferrin saturation), genetic testing, liver biopsy, MRI for iron quantification.

Treatment:
Regular therapeutic phlebotomy to remove excess iron, iron chelation therapy in cases where phlebotomy is not possible.

Medications:
Iron chelators such as deferoxamine , deferiprone , and deferasirox ; these are used to bind excess iron and promote its excretion in severe cases or when phlebotomy is not feasible.

Prevalence: How common the health condition is within a specific population.
Affects approximately 1 in 200-500 individuals of Northern European descent; more common in men than women.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Family history, genetic mutations (e.g., HFE C282Y and H63D mutations), being male (symptoms often manifest earlier in men).

Prognosis: The expected outcome or course of the condition over time.
Good with early diagnosis and management; untreated, it can lead to serious complications like liver cirrhosis, heart disease, and diabetes.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Liver cirrhosis, hepatocellular carcinoma, diabetes mellitus, heart failure, arthritis, hypothyroidism, and chronic fatigue.

Neuroendocrine Tumors (e.g., Insulinoma, Glucagonoma)

Specialty: Gastrointestinal

Category: Gallbladder and Biliary Tract Disorders

Sub-category: Pancreatic Tumors

Symptoms:
hypoglycemia symptoms such as sweating, palpitations, confusion, seizures (in insulinoma); hyperglycemia, weight loss, necrolytic migratory erythema (in glucagonoma); diarrhea; abdominal pain; flushing (in other nets)

Root Cause:
Tumors arising from the endocrine cells of the pancreas, often secreting hormones like insulin or glucagon in excess, leading to systemic metabolic effects.

How it's Diagnosed: videos
Hormone level measurement in blood (e.g., insulin, glucagon, gastrin); imaging such as CT, MRI, or somatostatin receptor scintigraphy (SRS); EUS-guided biopsy; functional imaging like DOTATATE PET scan

Treatment:
Array

Medications:
Somatostatin analogs (e.g., octreotide and lanreotide ) to control hormone secretion and tumor growth; everolimus (mTOR inhibitor) or sunitinib (tyrosine kinase inhibitor) for advanced or metastatic disease.

Prevalence: How common the health condition is within a specific population.
Rare; accounts for about 7% of all pancreatic cancers; incidence is approximately 1-5 per 100,000 population annually.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Genetic syndromes such as multiple endocrine neoplasia type 1 (MEN1); family history of NETs; chronic pancreatitis

Prognosis: The expected outcome or course of the condition over time.
Variable; depends on tumor type, size, and stage. Insulinomas typically have an excellent prognosis if surgically removed, while metastatic NETs have a median survival of 5-10 years with treatment.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Hormonal crises (e.g., severe hypoglycemia in insulinoma); metastasis to the liver or bone; nutritional deficiencies; intestinal obstruction or ischemia in advanced cases

Pancreatic Cysts

Specialty: Gastrointestinal

Category: Gallbladder and Biliary Tract Disorders

Sub-category: Other Pancreatic Disorders

Symptoms:
abdominal pain; nausea; vomiting; jaundice (if the cyst compresses the bile duct); unintended weight loss; palpable mass in the abdomen

Root Cause:
Fluid-filled sacs in the pancreas caused by a variety of conditions, such as pancreatitis, trauma, or neoplasms.

How it's Diagnosed: videos
Imaging studies like CT scan, MRI, or endoscopic ultrasound (EUS), combined with fine-needle aspiration for cyst fluid analysis.

Treatment:
Treatment depends on the type of cyst. Observation for benign or asymptomatic cysts, drainage, or surgical removal for symptomatic, infected, or potentially malignant cysts.

Medications:
Antibiotics like ciprofloxacin or metronidazole for infected cysts; proton pump inhibitors (PPIs) to reduce pancreatic inflammation in associated conditions.

Prevalence: How common the health condition is within a specific population.
Seen in approximately 10-20% of patients undergoing imaging for unrelated reasons; prevalence increases with age.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Acute or chronic pancreatitis, alcohol use, gallstones, abdominal trauma, family history of pancreatic cysts.

Prognosis: The expected outcome or course of the condition over time.
Generally good for benign cysts; malignant potential depends on the type (e.g., intraductal papillary mucinous neoplasm, or IPMN, has a higher risk).

Complications: Additional problems or conditions that may arise as a result of the original condition.
Risk of rupture, infection, hemorrhage, or transformation into pancreatic cancer.

Exocrine Pancreatic Insufficiency

Specialty: Gastrointestinal

Category: Pancreatic Disorders

Sub-category: Digestive Enzyme Deficiencies

Symptoms:
steatorrhea (fatty stools); diarrhea; weight loss; abdominal pain; bloating; malnutrition; vitamin deficiencies (a, d, e, k)

Root Cause:
Insufficient production of digestive enzymes by the pancreas, leading to impaired digestion and nutrient absorption.

How it's Diagnosed: videos
Fecal elastase-1 test, direct pancreatic function tests, imaging studies (CT or MRI) to identify underlying pancreatic pathology.

Treatment:
Pancreatic enzyme replacement therapy (PERT), dietary modifications (low-fat diet, supplementation of fat-soluble vitamins).

Medications:
Pancreatic enzyme supplements like pancrelipase (Creon, Zenpep, Pancrease); these contain lipase, protease, and amylase to aid digestion.

Prevalence: How common the health condition is within a specific population.
Estimated prevalence varies; more common in individuals with chronic pancreatitis, cystic fibrosis, or pancreatic surgery.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Chronic pancreatitis, cystic fibrosis, diabetes, pancreatic surgery, alcoholism.

Prognosis: The expected outcome or course of the condition over time.
Good with proper enzyme replacement and dietary management; untreated EPI can lead to severe malnutrition and quality-of-life impairment.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Malnutrition, osteoporosis, chronic diarrhea, increased risk of infections due to vitamin deficiencies.

Upper GI Bleeding (e.g., Varices, Peptic Ulcers)

Specialty: Gastrointestinal

Category: General and Miscellaneous GI Conditions

Sub-category: Gastrointestinal Bleeding

Symptoms:
hematemesis (vomiting blood); melena (black, tarry stools); weakness; dizziness; abdominal pain; shortness of breath; fatigue

Root Cause:
Bleeding from the upper gastrointestinal tract, commonly caused by peptic ulcers, gastric or esophageal varices, Mallory-Weiss tears, or erosive gastritis/esophagitis.

How it's Diagnosed: videos
Endoscopy (esophagogastroduodenoscopy), stool guaiac test, complete blood count (CBC) to check hemoglobin and hematocrit levels, and imaging if required.

Treatment:
Stabilization with intravenous fluids and blood transfusions if necessary, proton pump inhibitors (PPIs), endoscopic interventions (e.g., banding or sclerotherapy for varices, cauterization for ulcers), and in severe cases, surgery or transjugular intrahepatic portosystemic shunt (TIPS).

Medications:
Proton pump inhibitors (e.g., omeprazole , pantoprazole ) to reduce acid production, octreotide (a somatostatin analog) to control variceal bleeding, and antibiotics (e.g., ceftriaxone ) to prevent infections in variceal cases.

Prevalence: How common the health condition is within a specific population.
Affects 50-150 per 100,000 people annually; variceal bleeding is common in patients with liver cirrhosis.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Chronic use of NSAIDs, Helicobacter pylori infection, liver cirrhosis, alcohol abuse, coagulopathies, and high blood pressure in the portal vein.

Prognosis: The expected outcome or course of the condition over time.
With prompt treatment, most cases are manageable; however, recurrent bleeding and mortality are significant concerns, especially in variceal cases.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Hypovolemic shock, recurrent bleeding, organ failure, and in variceal cases, high mortality if untreated.

Gastroparesis

Specialty: Gastrointestinal

Category: General and Miscellaneous GI Conditions

Sub-category: Motility Disorders

Symptoms:
nausea; vomiting; early satiety; bloating; abdominal pain; weight loss; poor appetite

Root Cause:
Impaired gastric motility due to delayed emptying of the stomach without mechanical obstruction; often associated with nerve or muscle dysfunction.

How it's Diagnosed: videos
Gastric emptying studies (e.g., scintigraphy, breath tests), upper endoscopy to rule out obstruction, and imaging such as CT or MRI to assess anatomy.

Treatment:
Dietary modifications (small, low-fat, low-fiber meals), prokinetic medications, antiemetics, and in severe cases, interventions like gastric electrical stimulation or jejunal feeding tubes.

Medications:
Prokinetic agents such as metoclopramide (a dopamine antagonist) and erythromycin (a macrolide antibiotic) are prescribed to enhance gastric motility. Antiemetics, such as ondansetron (a serotonin 5-HT3 receptor antagonist) or promethazine (a phenothiazine derivative ), are used to control nausea and vomiting.

Prevalence: How common the health condition is within a specific population.
Affects an estimated 4% of the U.S. population, with higher prevalence in individuals with diabetes or post-surgical complications.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Diabetes mellitus (type 1 and 2), prior abdominal surgery, systemic disorders affecting nerves or muscles (e.g., Parkinson’s disease, scleroderma), and certain medications (e.g., opioids, anticholinergics).

Prognosis: The expected outcome or course of the condition over time.
Varies by severity; manageable with lifestyle changes and medications, but symptoms can persist and significantly affect quality of life.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Severe malnutrition, dehydration, bezoar formation, fluctuating blood glucose levels in diabetic patients, and impaired medication absorption.

Intestinal Pseudo-Obstruction

Specialty: Gastrointestinal

Category: General and Miscellaneous GI Conditions

Sub-category: Motility Disorders

Symptoms:
abdominal pain; bloating; nausea; vomiting; constipation; diarrhea; malnutrition; failure to thrive in children

Root Cause:
Abnormal motility of the intestines due to dysfunction of the smooth muscle or nerves; mimics a mechanical obstruction but without a physical blockage.

How it's Diagnosed: videos
Abdominal X-rays, CT scans, manometry to evaluate intestinal contractions, and full-thickness biopsies to examine underlying neuromuscular abnormalities.

Treatment:
Management focuses on treating symptoms with dietary adjustments (low-residue or elemental diets), enteral or parenteral nutrition, prokinetic agents, and in some cases, surgical decompression.

Medications:
Prokinetic agents such as neostigmine (a cholinesterase inhibitor) and metoclopramide (a dopamine antagonist) are used to enhance motility. Antispasmodics, such as hyoscine (an anticholinergic agent), may be used to manage painful cramping. Antibiotics, like rifaximin (a gut-specific antibiotic), may be prescribed for bacterial overgrowth.

Prevalence: How common the health condition is within a specific population.
Rare, with an estimated prevalence of fewer than 1 in 100,000 individuals; can occur as a primary (idiopathic) condition or secondary to systemic diseases.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Genetic predispositions, underlying conditions like scleroderma, systemic lupus erythematosus, neurological disorders, or prior abdominal surgery.

Prognosis: The expected outcome or course of the condition over time.
Chronic and often progressive; prognosis depends on the underlying cause and response to treatment. Early intervention with nutritional support can improve outcomes.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Severe malnutrition, intestinal perforation, bacterial overgrowth, sepsis, and dependency on parenteral nutrition in advanced cases.

Peritonitis (Spontaneous Bacterial or Secondary)

Specialty: Gastrointestinal

Category: General and Miscellaneous GI Conditions

Sub-category: Peritoneal Disorders

Symptoms:
abdominal pain; fever; nausea; vomiting; bloating; loss of appetite; rebound tenderness; altered mental status (in severe cases)

Root Cause:
Inflammation of the peritoneum caused by bacterial infection, either spontaneous (usually due to liver disease and ascites) or secondary to conditions like a perforated appendix or bowel injury.

How it's Diagnosed: videos
Clinical examination, imaging (CT scan or ultrasound), and diagnostic paracentesis (analysis of peritoneal fluid for white blood cell count, Gram stain, and culture).

Treatment:
Immediate treatment includes antibiotics to target causative bacteria, supportive care (IV fluids, pain management), and surgery (in secondary peritonitis) to repair the underlying source of infection.

Medications:
Broad-spectrum antibiotics such as cefotaxime or piperacillin-tazobactam (antibacterial). In cases of fungal involvement, antifungals like fluconazole may be used.

Prevalence: How common the health condition is within a specific population.
Spontaneous bacterial peritonitis occurs in 10-30% of patients with cirrhosis and ascites. Secondary peritonitis prevalence depends on underlying conditions like appendicitis or bowel perforation.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Chronic liver disease with ascites, peritoneal dialysis, abdominal surgery, gastrointestinal perforations, trauma, and immunosuppression.

Prognosis: The expected outcome or course of the condition over time.
Prognosis varies; spontaneous bacterial peritonitis has a 20-40% mortality rate, which improves with prompt treatment. Secondary peritonitis requires surgical intervention and can lead to serious complications without timely management.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Sepsis, multi-organ failure, abscess formation, and recurrent infections.

Peptic ulcer disease

Specialty: Senior Health and Geriatrics

Category: Chronic Diseases and Multimorbidity

Sub-category: Gastrointestinal and Hepatic Disorders

Symptoms:
abdominal pain; bloating; nausea; vomiting; heartburn; loss of appetite; weight loss

Root Cause:
Ulcers in the stomach lining or the first part of the small intestine caused by an imbalance between stomach acid and protective factors.

How it's Diagnosed: videos
Based on symptoms, endoscopy, and tests for H. pylori infection (blood, breath, or stool tests).

Treatment:
Proton pump inhibitors (PPIs), antibiotics for H. pylori infection, antacids, and sometimes surgery.

Medications:
Proton pump inhibitors (e.g., lansoprazole ), H2 blockers (e.g., ranitidine), antibiotics (e.g., clarithromycin , amoxicillin for H. pylori), and antacids.

Prevalence: How common the health condition is within a specific population.
Affects 10-15% of people at some point in their lives, more common in those aged 55-70.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
H. pylori infection, long-term NSAID use, alcohol use, smoking, stress, and spicy foods.

Prognosis: The expected outcome or course of the condition over time.
With appropriate treatment, most ulcers heal within a few weeks; recurrence is common if risk factors are not managed.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Gastrointestinal bleeding, perforation, gastric cancer.

Diverticulosis/Diverticulitis

Specialty: Senior Health and Geriatrics

Category: Chronic Diseases and Multimorbidity

Sub-category: Gastrointestinal and Hepatic Disorders

Symptoms:
abdominal pain; fever; nausea; change in bowel habits; constipation or diarrhea; bloating; rectal bleeding

Root Cause:
Diverticulosis is the formation of small pouches in the colon; diverticulitis occurs when these pouches become inflamed or infected.

How it's Diagnosed: videos
Colonoscopy, CT scan, or abdominal ultrasound.

Treatment:
Antibiotics for infection, dietary modifications (high-fiber diet), and pain relief; in severe cases, surgery.

Medications:
Antibiotics (e.g., ciprofloxacin , metronidazole ), pain relievers (e.g., acetaminophen ), and antispasmodics (e.g., dicyclomine ).

Prevalence: How common the health condition is within a specific population.
Affects 50-60% of individuals aged 60 and older in Western populations.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Age, low-fiber diet, obesity, physical inactivity, and smoking.

Prognosis: The expected outcome or course of the condition over time.
Generally manageable with lifestyle changes, but recurrent episodes of diverticulitis may require surgical intervention.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Abscesses, perforation, peritonitis, fistulas, and bleeding.

Hepatitis (Chronic, e.g., Hepatitis C)

Specialty: Senior Health and Geriatrics

Category: Chronic Diseases and Multimorbidity

Sub-category: Gastrointestinal and Hepatic Disorders

Symptoms:
fatigue; jaundice; abdominal pain; dark urine; loss of appetite; nausea; itchy skin

Root Cause:
Chronic inflammation of the liver caused by the hepatitis C virus (HCV), leading to potential liver damage over time.

How it's Diagnosed: videos
Blood tests to detect HCV antibodies and RNA, liver function tests, and liver biopsy or elastography for assessing liver damage.

Treatment:
Antiviral medications such as direct-acting antivirals (DAAs), and lifestyle changes to manage symptoms.

Medications:
Direct-acting antivirals (DAAs) such as sofosbuvir , ledipasvir , glecaprevir /pibrentasvir , ribavirin in some cases.

Prevalence: How common the health condition is within a specific population.
Hepatitis C affects approximately 1-2% of the global population, with higher prevalence among older adults and those with a history of intravenous drug use.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
History of intravenous drug use, blood transfusions prior to 1992, needle sharing, unprotected sex, and tattoos or piercings in unsanitary conditions.

Prognosis: The expected outcome or course of the condition over time.
With appropriate antiviral therapy, the infection can be cured, but chronic infection can lead to cirrhosis, liver failure, or liver cancer if untreated.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Cirrhosis, liver failure, liver cancer (hepatocellular carcinoma), and portal hypertension.

Mastocytosis

Specialty: Allergies and Immunology

Category: Other Related Disorders

Sub-category: Mast Cell Disorders

Symptoms:
flushing; itching; skin lesions (urticaria pigmentosa); abdominal pain; diarrhea; low blood pressure; anaphylaxis

Root Cause:
Abnormal accumulation and activation of mast cells in the skin, bone marrow, or other organs, leading to excessive histamine release.

How it's Diagnosed: videos
Skin or bone marrow biopsy showing increased mast cells, blood tryptase levels, and genetic testing (e.g., KIT mutation).

Treatment:
Symptom management with antihistamines, leukotriene inhibitors, mast cell stabilizers (e.g., cromolyn sodium), and avoidance of triggers. Severe cases may require tyrosine kinase inhibitors.

Medications:
Antihistamines (e.g., Cetirizine , Diphenhydramine ), mast cell stabilizers (e.g., Cromolyn Sodium), and epinephrine for anaphylaxis.

Prevalence: How common the health condition is within a specific population.
Rare; estimated to affect 1 in 10,000 to 1 in 20,000 individuals.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Mutations in the KIT gene, certain environmental triggers, and other immune or systemic disorders.

Prognosis: The expected outcome or course of the condition over time.
Varies; indolent forms have a good prognosis, while aggressive forms can lead to organ dysfunction.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Osteoporosis, organ failure, and anaphylaxis due to mast cell degranulation.

Eosinophilic Esophagitis (EoE)

Specialty: Allergies and Immunology

Category: Other Related Disorders

Sub-category: Eosinophilic Disorders

Symptoms:
difficulty swallowing; food impaction; chest pain; heartburn; abdominal pain; vomiting in children; failure to thrive in children

Root Cause:
Chronic immune-mediated inflammation of the esophagus with eosinophil infiltration, often triggered by food allergens.

How it's Diagnosed: videos
Upper endoscopy with esophageal biopsy showing eosinophilic infiltration; allergy testing may identify triggers.

Treatment:
Elimination diets, proton pump inhibitors, corticosteroids (topical or systemic), and esophageal dilation for strictures.

Medications:
Proton pump inhibitors (e.g., Omeprazole ), topical corticosteroids (e.g., Fluticasone ), and elimination diets.

Prevalence: How common the health condition is within a specific population.
Approximately 1 in 2,000 individuals in the U.S.; more common in males.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Personal or family history of allergic diseases, including asthma, eczema, or food allergies.

Prognosis: The expected outcome or course of the condition over time.
Good with proper treatment, but symptoms often recur if treatment is stopped.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Esophageal strictures, food impaction, and chronic inflammation leading to fibrosis.

Eosinophilic Gastroenteritis

Specialty: Allergies and Immunology

Category: Other Related Disorders

Sub-category: Eosinophilic Disorders

Symptoms:
abdominal pain; nausea; diarrhea; vomiting; weight loss; fatigue; anemia

Root Cause:
Eosinophilic infiltration of the gastrointestinal tract, likely triggered by food or environmental allergens.

How it's Diagnosed: videos
Endoscopy with biopsy showing eosinophilic infiltration, imaging studies, and blood tests for eosinophilia.

Treatment:
Elimination diets, corticosteroids, and symptom management (e.g., anti-nausea medications).

Medications:
Corticosteroids (e.g., Prednisone ) and dietary modifications.

Prevalence: How common the health condition is within a specific population.
Rare; precise prevalence is unknown.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Allergic diseases, family history of eosinophilic disorders, and certain infections.

Prognosis: The expected outcome or course of the condition over time.
Chronic but manageable with treatment; symptoms may relapse without ongoing management.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Bowel obstruction, malabsorption, and perforation in severe cases.

Hereditary Angioedema (HAE)

Specialty: Allergies and Immunology

Category: Other Related Disorders

Symptoms:
swelling of the skin and mucosal tissues; abdominal pain; nausea; vomiting; difficulty breathing; laryngeal swelling that may lead to airway obstruction

Root Cause:
Genetic mutation leading to a deficiency or dysfunction of C1 esterase inhibitor (C1-INH), causing uncontrolled activation of the complement system and increased bradykinin production.

How it's Diagnosed: videos
Blood tests measuring C1-INH levels and function, complement component C4 levels, and genetic testing for mutations in the SERPING1 gene.

Treatment:
C1-INH replacement therapy, bradykinin receptor antagonists (e.g., icatibant), kallikrein inhibitors (e.g., lanadelumab), and prophylactic medications for preventing attacks.

Medications:
C1 esterase inhibitor replacement therapy, bradykinin receptor antagonists (e.g., Icatibant ), and androgens (e.g., Danazol ).

Prevalence: How common the health condition is within a specific population.
Estimated at 1 in 50,000 to 1 in 100,000 individuals worldwide.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Family history of HAE (autosomal dominant inheritance), stress, trauma, infections, hormonal changes, certain medications (e.g., ACE inhibitors).

Prognosis: The expected outcome or course of the condition over time.
With proper management, most patients can lead normal lives; untreated cases may result in life-threatening airway obstruction.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Potentially fatal laryngeal edema, psychological distress due to unpredictable swelling episodes, reduced quality of life, and delays in diagnosis.

Diaphragmatic rupture (from blunt or penetrating trauma)

Specialty: Trauma and Injuries

Category: Thoracic (Chest) Injuries

Sub-category: Diaphragmatic Injuries

Symptoms:
shortness of breath; chest pain; abdominal pain; respiratory distress; decreased breath sounds on the affected side; abdominal contents visible in the chest on imaging

Root Cause:
A tear in the diaphragm caused by blunt or penetrating trauma, allowing abdominal organs to herniate into the thoracic cavity.

How it's Diagnosed: videos
Physical examination, chest X-ray, CT scan, ultrasound (FAST scan), or diagnostic laparoscopy.

Treatment:
Surgical repair of the diaphragm, typically through thoracotomy or laparotomy. Emergency management may include stabilizing the patient’s airway, breathing, and circulation (ABCs).

Medications:
Pain relievers (e.g., acetaminophen , opioids), antibiotics to prevent infection if there is organ herniation or contamination (e.g., broad-spectrum antibiotics like ceftriaxone or metronidazole ). These medications are supportive and adjunct to surgical treatment.

Prevalence: How common the health condition is within a specific population.
Rare; occurs in approximately 5-7% of patients with significant blunt trauma to the chest or abdomen, and in a higher proportion of penetrating trauma cases.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
High-energy blunt trauma (e.g., motor vehicle collisions, falls from a height), penetrating injuries to the chest or abdomen, prior surgical or congenital diaphragmatic defects.

Prognosis: The expected outcome or course of the condition over time.
Good with timely surgical intervention. Delayed diagnosis can increase morbidity and mortality due to complications like strangulation of herniated organs or respiratory compromise.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Respiratory distress, herniation and strangulation of abdominal organs, infection, sepsis, multi-organ failure, recurrence of the rupture if not properly repaired.

Retroperitoneal Hematoma

Specialty: Trauma and Injuries

Category: Blunt Abdominal Trauma

Symptoms:
abdominal pain; flank pain; back pain; bruising around the flank (grey-turner's sign); hemodynamic instability (e.g., low blood pressure); nausea and vomiting; abdominal distension

Root Cause:
Blood accumulation in the retroperitoneal space due to trauma or injury to retroperitoneal structures (e.g., kidneys, adrenal glands, aorta, or major vessels). Causes may include blunt force trauma, pelvic fractures, or ruptured aneurysms.

How it's Diagnosed: videos
Diagnosis involves clinical examination and imaging studies. CT scan with contrast is the gold standard for visualizing retroperitoneal bleeding and identifying the source. Ultrasound (FAST) may provide initial clues in trauma settings. Blood tests may reveal anemia or coagulopathy.

Treatment:
Management depends on the severity and cause. Mild cases may involve monitoring and supportive care, while severe cases may require surgical intervention, such as exploratory laparotomy or angiographic embolization to control bleeding.

Medications:
Medications are supportive and may include - Blood transfusions (if anemia or severe blood loss occurs). IV fluids to maintain blood pressure. Pain relievers like acetaminophen or opioids for severe pain. Antibiotics if infection is suspected due to tissue necrosis or open injuries. Anticoagulant reversal agents (e.g., vitamin K, protamine sulfate) if bleeding is associated with anticoagulant use.

Prevalence: How common the health condition is within a specific population.
Exact prevalence is unknown but occurs most commonly in patients with blunt trauma, accounting for approximately 15% of abdominal injuries requiring imaging or intervention.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Blunt abdominal trauma; pelvic fractures; anticoagulant use; advanced age; vascular abnormalities (e.g., aneurysms); bleeding disorders; previous abdominal surgery

Prognosis: The expected outcome or course of the condition over time.
Prognosis depends on the severity of bleeding and the speed of intervention. Early diagnosis and treatment result in a good prognosis, but severe cases with delayed management can lead to significant morbidity and mortality.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Hemorrhagic shock; organ ischemia or failure; infection or abscess formation; compartment syndrome; death (in severe untreated cases)

Stab Wounds

Specialty: Trauma and Injuries

Category: Penetrating Abdominal Trauma

Symptoms:
visible open wound; abdominal pain; bleeding; shock (rapid pulse, low blood pressure); nausea or vomiting; rigidity or guarding of abdominal muscles

Root Cause:
Penetration of the abdominal wall by a sharp object, potentially damaging internal organs, blood vessels, or causing infection.

How it's Diagnosed: videos
Physical examination, imaging studies such as CT scan or ultrasound, diagnostic peritoneal lavage, and exploration during surgery.

Treatment:
Initial stabilization (control bleeding, fluid resuscitation), surgical exploration to assess and repair internal injuries, wound care, and infection prevention.

Medications:
Antibiotics (e.g., cefazolin , metronidazole ) to prevent infection; analgesics (e.g., opioids like morphine for severe pain); tetanus prophylaxis if needed.

Prevalence: How common the health condition is within a specific population.
Common in cases of violent assaults or accidents, with variations depending on geographic and social contexts.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
High-crime areas, carrying weapons, engaging in high-risk activities or disputes.

Prognosis: The expected outcome or course of the condition over time.
Dependent on the extent of the injury and timeliness of medical intervention; recovery is good if injuries are limited to superficial tissues.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Hemorrhage, infection (peritonitis or abscess), organ damage (e.g., liver, spleen, bowel), shock, and death if untreated.

Non-accidental trauma (child abuse-related injuries)

Specialty: Trauma and Injuries

Category: Pediatric Trauma

Sub-category: Common Pediatric Injuries

Symptoms:
unexplained bruises or burns; fractures in various healing stages; head injuries; abdominal pain; signs of neglect or poor hygiene

Root Cause:
Non-accidental trauma is caused by intentional harm or injury inflicted upon a child, often by a caregiver or family member.

How it's Diagnosed: videos
Diagnosis involves a careful history, physical examination, and imaging studies. Suspicion of non-accidental trauma leads to a multidisciplinary team assessment, including social work, radiology, and sometimes forensic evaluation.

Treatment:
Treatment focuses on immediate medical care for injuries, followed by ensuring the child’s safety and providing support to address the emotional and psychological consequences of abuse. Involves coordination with child protection services.

Medications:
Pain management with analgesics such as acetaminophen (Tylenol ) or ibuprofen (Advil) for physical injuries. Psychiatric medications may be used to treat anxiety, depression, or PTSD related to trauma.

Prevalence: How common the health condition is within a specific population.
Approximately 1 in 4 children will experience some form of abuse before the age of 18, and it is responsible for a significant proportion of pediatric injury hospitalizations.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Factors such as domestic violence, substance abuse, mental illness in caregivers, and poverty increase the risk of non-accidental trauma.

Prognosis: The expected outcome or course of the condition over time.
The prognosis varies depending on the severity of the injuries and the timing of intervention. Immediate medical and psychological support can improve long-term outcomes.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Long-term physical and psychological consequences such as developmental delays, emotional trauma, and physical disabilities are possible. In extreme cases, abuse can lead to death.

Atheroembolic Renal Disease

Specialty: Nephrology

Category: Vascular Kidney Diseases

Symptoms:
sudden kidney dysfunction; skin changes (blue toes or livedo reticularis); abdominal pain; fever; weight loss

Root Cause:
Cholesterol crystals or debris from atherosclerotic plaques embolize to the renal arteries, causing ischemia and inflammation in the kidneys.

How it's Diagnosed: videos
Kidney biopsy, imaging studies (angiography, CT), and lab tests (eosinophilia, elevated creatinine).

Treatment:
Supportive care, management of underlying atherosclerosis, and avoidance of anticoagulation if possible.

Medications:
Statins, antiplatelet agents (e.g., aspirin , clopidogrel ), and occasionally corticosteroids for inflammation.

Prevalence: How common the health condition is within a specific population.
Rare but increasing with the rise of cardiovascular interventions.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Atherosclerosis, recent vascular procedures, advanced age, and hypertension.

Prognosis: The expected outcome or course of the condition over time.
Poor if left untreated; progressive renal dysfunction is common.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Chronic kidney disease, end-stage renal disease, and systemic embolization.

Wilms Tumor (Nephroblastoma)

Specialty: Oncology

Category: Solid Tumors

Sub-category: Genitourinary Cancers

Symptoms:
abdominal swelling or mass; abdominal pain; fever; blood in urine; nausea or vomiting

Root Cause:
A rare kidney cancer in children caused by genetic mutations affecting kidney development.

How it's Diagnosed: videos
Ultrasound, CT or MRI, and biopsy; genetic testing may be performed.

Treatment:
Surgery (nephrectomy), chemotherapy, and radiation therapy (in advanced stages).

Medications:
Chemotherapeutic agents like vincristine , actinomycin D, and doxorubicin are used in combination therapy.

Prevalence: How common the health condition is within a specific population.
Wilms tumor affects about 1 in 10,000 children, making it the most common pediatric kidney cancer.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Family history of Wilms tumor, genetic syndromes (e.g., WAGR syndrome, Beckwith-Wiedemann syndrome).

Prognosis: The expected outcome or course of the condition over time.
Favorable prognosis with a 5-year survival rate exceeding 90% for localized cases.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Kidney function loss, metastases to lungs or liver, and complications from chemotherapy or radiation.

Peritoneal Dialysis Infections

Specialty: Nephrology

Category: Dialysis and Transplant-Related Conditions

Sub-category: Dialysis-Associated Complications

Symptoms:
abdominal pain; cloudy peritoneal dialysis fluid; fever; nausea; redness or drainage at catheter site

Root Cause:
Bacterial or fungal infection of the peritoneal cavity, often caused by contamination during the exchange process or catheter-related issues.

How it's Diagnosed: videos
Analysis of peritoneal dialysis fluid for elevated white blood cell count and culture to identify the causative organism.

Treatment:
Antibiotics or antifungal agents administered intraperitoneally or intravenously, catheter removal if the infection is severe or recurrent, and temporary cessation of peritoneal dialysis.

Medications:
First-line treatments include intraperitoneal antibiotics such as vancomycin (for Gram-positive organisms) and ceftazidime (for Gram-negative organisms). Antifungal agents like fluconazole may be prescribed for fungal infections.

Prevalence: How common the health condition is within a specific population.
Occurs in approximately 20-25% of peritoneal dialysis patients annually.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Poor hygiene during exchanges, diabetes, older age, use of a contaminated catheter, or a history of prior infections.

Prognosis: The expected outcome or course of the condition over time.
Good with early and appropriate treatment; untreated or severe cases can lead to peritonitis and necessitate a switch to hemodialysis.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Adhesions, loss of peritoneal membrane function, sepsis, and eventual requirement for a new dialysis modality.

Colorectal Cancer

Specialty: Oncology

Category: Solid Tumors

Sub-category: Gastrointestinal Cancers

Symptoms:
rectal bleeding; changes in bowel habits; abdominal pain; unexplained weight loss; fatigue; persistent bloating; iron-deficiency anemia; narrow stools

Root Cause:
Malignant tumor formation in the colon or rectum, often due to genetic mutations (e.g., APC gene mutations) or progression from adenomatous polyps.

How it's Diagnosed: videos
Colonoscopy with biopsy, stool-based tests (FIT, FOBT, or DNA tests), CT colonography, and imaging studies (CT or MRI) for staging.

Treatment:
Treatment depends on stage and includes surgery (colectomy), chemotherapy, targeted therapy, and radiation therapy (especially for rectal cancer).

Medications:
Common chemotherapy agents include oxaliplatin , capecitabine , and 5-fluorouracil; targeted therapies include bevacizumab (anti-VEGF) and cetuximab or panitumumab (anti-EGFR for RAS wild-type tumors). Immunotherapy, such as pembrolizumab , is used for MSI-high tumors.

Prevalence: How common the health condition is within a specific population.
Over 150,000 new cases diagnosed annually in the United States; the third most common cancer worldwide.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Family history, inflammatory bowel disease (IBD), obesity, sedentary lifestyle, high red/processed meat consumption, and low fiber intake.

Prognosis: The expected outcome or course of the condition over time.
Early detection leads to excellent outcomes (90% 5-year survival for localized cancer); advanced cancer has poorer outcomes.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Bowel obstruction, perforation, metastasis (commonly to liver and lungs), and recurrence after treatment.

Rectal Cancer

Specialty: Oncology

Category: Solid Tumors

Sub-category: Gastrointestinal Cancers

Symptoms:
rectal bleeding; narrow stools; bowel habit changes; abdominal pain; fatigue; iron-deficiency anemia

Root Cause:
Malignant tumors develop in the rectum, often due to genetic mutations or adenomatous polyps.

How it's Diagnosed: videos
Colonoscopy with biopsy, rectal ultrasound, CT/MRI for staging, and stool tests.

Treatment:
Surgery (low anterior resection or abdominoperineal resection), radiation therapy, chemotherapy, or targeted therapy.

Medications:
Medications include capecitabine and oxaliplatin for chemotherapy; targeted therapies like bevacizumab and cetuximab may also be used.

Prevalence: How common the health condition is within a specific population.
Around 45,000 cases diagnosed annually in the United States.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Similar to colon cancer, including family history, obesity, IBD, and poor diet.

Prognosis: The expected outcome or course of the condition over time.
Good for early-stage rectal cancer; worsens with advanced stages.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Bowel obstruction, fistulas, metastasis, and recurrence.

Fibrolamellar Hepatocellular Carcinoma

Specialty: Oncology

Category: Solid Tumors

Sub-category: Gastrointestinal Cancers

Symptoms:
abdominal pain; unexplained weight loss; fatigue; nausea; jaundice; lump in the abdomen

Root Cause:
Rare subtype of HCC occurring in young adults without underlying liver disease; linked to DNAJB1-PRKACA fusion mutation.

How it's Diagnosed: videos
Imaging (CT, MRI), biopsy, and liver function tests.

Treatment:
Surgical resection is the main treatment; systemic therapies are less effective, though some targeted therapies are under investigation.

Medications:
No established standard systemic therapy; clinical trials for targeted and immunotherapy drugs are ongoing.

Prevalence: How common the health condition is within a specific population.
Extremely rare, accounting for less than 1% of liver cancers.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Not associated with typical liver cancer risk factors; genetic mutations are implicated.

Prognosis: The expected outcome or course of the condition over time.
Better prognosis than typical HCC if treated early; 5-year survival rates vary based on resectability.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Recurrence after surgery, metastasis to other organs.

Bile Duct Cancer (Cholangiocarcinoma)

Specialty: Oncology

Category: Solid Tumors

Sub-category: Gastrointestinal Cancers

Symptoms:
jaundice; itchy skin; abdominal pain; dark urine; pale stools; unintended weight loss; fatigue

Root Cause:
Malignant growth in the bile ducts, often associated with chronic inflammation, bile duct abnormalities, or liver fluke infections.

How it's Diagnosed: videos
Imaging (MRI, CT, or MRCP), blood tests for tumor markers (CA 19-9, CEA), and biopsy.

Treatment:
Surgery (bile duct resection or liver transplantation), chemotherapy, radiation therapy, and targeted therapy.

Medications:
Common chemotherapy drugs include gemcitabine and cisplatin ; targeted therapies like ivosidenib (IDH1 inhibitor) are used for specific mutations.

Prevalence: How common the health condition is within a specific population.
Rare, with approximately 8,000 cases diagnosed annually in the United States.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Primary sclerosing cholangitis (PSC), bile duct abnormalities, liver fluke infections, chronic liver disease, and older age.

Prognosis: The expected outcome or course of the condition over time.
Poor prognosis, with a 5-year survival rate of about 10-15% overall, but better if caught early.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Biliary obstruction, liver failure, and metastasis.

Gastrointestinal Stromal Tumor (GIST)

Specialty: Oncology

Category: Solid Tumors

Sub-category: Gastrointestinal Cancers

Symptoms:
abdominal pain; nausea; vomiting; gastrointestinal bleeding; unintended weight loss; anemia; abdominal swelling

Root Cause:
Rare mesenchymal tumors arising from interstitial cells of Cajal in the gastrointestinal tract, often caused by mutations in the KIT or PDGFRA genes.

How it's Diagnosed: videos
Imaging (CT or MRI), endoscopy with biopsy, and molecular testing for KIT or PDGFRA mutations.

Treatment:
Surgery is the primary treatment for localized tumors; systemic therapy is used for advanced or metastatic cases.

Medications:
Targeted therapy with imatinib (tyrosine kinase inhibitor) is the first-line treatment; sunitinib and regorafenib are used for resistant or advanced cases.

Prevalence: How common the health condition is within a specific population.
Very rare, with an incidence of 4,000-6,000 cases annually in the United States.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
No strong environmental risk factors; some cases are linked to genetic syndromes like neurofibromatosis type 1.

Prognosis: The expected outcome or course of the condition over time.
Excellent for localized tumors treated surgically; 5-year survival rate for metastatic disease is about 50% with effective targeted therapy.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Tumor rupture leading to peritonitis, metastasis (commonly to the liver), and recurrence.

Germ Cell Tumors

Specialty: Oncology

Category: Sarcomas

Sub-category: Pediatric Cancers

Symptoms:
abdominal pain; swelling; mass or lump; difficulty breathing; chest pain

Root Cause:
Tumors originating from germ cells (cells that give rise to sperm and eggs) in the gonads or extragonadal sites.

How it's Diagnosed: videos
Imaging (CT, MRI, ultrasound), biopsy, blood tests (e.g., for tumor markers like AFP, hCG).

Treatment:
Surgery, chemotherapy, radiation therapy.

Medications:
Chemotherapy drugs such as cisplatin , etoposide , bleomycin .

Prevalence: How common the health condition is within a specific population.
Relatively rare, but germ cell tumors are the most common type of ovarian and testicular cancer in children.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Genetic syndromes, prior gonadal surgery.

Prognosis: The expected outcome or course of the condition over time.
Generally good prognosis with surgery and chemotherapy, particularly for localized tumors.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Recurrence, infertility, long-term effects of treatment.

Adrenal Cortical Carcinoma

Specialty: Oncology

Category: Solid Tumors

Sub-category: Endocrine Cancers

Symptoms:
abdominal pain; back pain; weight loss; hypertension; fatigue; excessive hair growth (in women)

Root Cause:
Rare and aggressive cancer of the adrenal cortex; often associated with mutations in the TP53 gene or familial syndromes like Li-Fraumeni syndrome.

How it's Diagnosed: videos
Imaging (CT, MRI), blood tests for hormone levels (cortisol, aldosterone, etc.), biopsy, and genetic testing for mutations.

Treatment:
Surgical resection, adjuvant chemotherapy (etoposide, doxorubicin), and mitotane (a drug used to treat adrenal cancer).

Medications:
Mitotane (adrenal cytotoxic drug), etoposide (chemotherapy), doxorubicin (chemotherapy).

Prevalence: How common the health condition is within a specific population.
Very rare, accounting for less than 0.5% of all cancers.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Genetic conditions such as Li-Fraumeni syndrome, Beckwith-Wiedemann syndrome, and familial adenomatous polyposis.

Prognosis: The expected outcome or course of the condition over time.
Prognosis is poor with a 5-year survival rate of 15–40% for localized disease; survival rates drop significantly for advanced cases.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Metastasis to liver, lungs, and lymph nodes; recurrence after treatment; and hormonal imbalances leading to Cushing's syndrome, Conn's syndrome, or virilization.

Wilms Tumor

Specialty: Oncology

Category: Sarcomas

Sub-category: Pediatric Cancers

Symptoms:
abdominal mass; abdominal pain; fever; blood in urine; high blood pressure; poor appetite; weight loss

Root Cause:
A type of kidney cancer that primarily affects children, usually involving one kidney, but can occasionally involve both.

How it's Diagnosed: videos
Ultrasound, CT scan, MRI, biopsy, blood and urine tests.

Treatment:
Surgery, chemotherapy, radiation therapy.

Medications:
Chemotherapy agents like vincristine , actinomycin D, and doxorubicin ; pain relievers such as ibuprofen or morphine for post-surgical pain management.

Prevalence: How common the health condition is within a specific population.
Occurs in about 7-10% of childhood cancers, with around 500 cases diagnosed annually in the U.S.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Genetic conditions like WAGR syndrome, Beckwith-Wiedemann syndrome, or Li-Fraumeni syndrome.

Prognosis: The expected outcome or course of the condition over time.
90% survival rate in localized cases; survival rates decrease in cases with metastasis.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Recurrence, kidney damage, long-term effects from chemotherapy or radiation, high blood pressure.

Neuroendocrine Tumors (NETs)

Specialty: Oncology

Category: Sarcomas

Sub-category: Rare Cancers

Symptoms:
abdominal pain; diarrhea; flushing; wheezing; fatigue; unexplained weight loss; heart palpitations; skin rashes

Root Cause:
Neuroendocrine tumors are cancers that develop from neuroendocrine cells, which have characteristics of both nerve cells and hormone-producing cells. These tumors can occur in various parts of the body, most commonly the gastrointestinal tract, pancreas, and lungs. They can secrete hormones, leading to symptoms like flushing and diarrhea.

How it's Diagnosed: videos
Diagnosis is through imaging techniques such as CT scans, MRIs, or PET scans to locate the tumor, blood tests for elevated hormone levels (e.g., chromogranin A, serotonin), and biopsy for histological confirmation.

Treatment:
Treatment often involves surgical resection of the tumor, if localized, and medications such as somatostatin analogs (e.g., octreotide or lanreotide) to manage symptoms. Chemotherapy and targeted therapies (e.g., everolimus, sunitinib) may be used for advanced or metastatic disease. In some cases, liver-directed treatments (like embolization) or peptide receptor radionuclide therapy (PRRT) are used for metastases.

Medications:
Somatostatin analogs like octreotide and lanreotide help control the symptoms and reduce hormone secretion. These are classified as peptide receptor drugs. For advanced NETs, chemotherapy agents like temozolomide or streptozocin (alkylating agents) and targeted therapies like everolimus (an mTOR inhibitor) and sunitinib (a tyrosine kinase inhibitor) may be used.

Prevalence: How common the health condition is within a specific population.
The incidence of NETs has been increasing, with an estimated prevalence of around 2-3 cases per 100,000 individuals per year. NETs are rare but more common in older adults, with gastrointestinal and pancreatic NETs being the most frequent.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Risk factors include age (more common in people over 50), a family history of NETs, genetic conditions like multiple endocrine neoplasia type 1 (MEN1), von Hippel-Lindau syndrome, and neurofibromatosis type 1.

Prognosis: The expected outcome or course of the condition over time.
Prognosis varies based on tumor type, location, and stage at diagnosis. For localized NETs, the 5-year survival rate is generally favorable (70-80%), while advanced or metastatic NETs have a lower survival rate (around 30-40%).

Complications: Additional problems or conditions that may arise as a result of the original condition.
Complications include metastasis to the liver or other organs, carcinoid syndrome (which includes symptoms like flushing, diarrhea, and heart valve issues), hormonal imbalances, and malabsorption due to gastrointestinal involvement.

Small Intestine Cancer

Specialty: Oncology

Category: Sarcomas

Sub-category: Rare Cancers

Symptoms:
abdominal pain; unexplained weight loss; nausea; vomiting; jaundice; blood in stool; changes in bowel habits; fatigue

Root Cause:
Small intestine cancer develops in the cells of the small intestine, often affecting the epithelial or neuroendocrine cells. The exact cause is unknown, but genetic mutations and conditions like Crohn's disease, celiac disease, and Lynch syndrome can increase the risk.

How it's Diagnosed: videos
Diagnosis is typically through imaging studies like CT scans, MRIs, or endoscopy (e.g., capsule endoscopy or push enteroscopy). Biopsy is used to confirm the diagnosis through histological examination of the tumor tissue.

Treatment:
Treatment involves surgery to remove the tumor if detected early. Chemotherapy (e.g., 5-fluorouracil, capecitabine, or oxaliplatin) is often used for advanced disease. Radiation therapy may be used in some cases. Targeted therapy or immunotherapy may also be considered depending on tumor type.

Medications:
Chemotherapy drugs like 5-fluorouracil (an antimetabolite) and oxaliplatin (a platinum-based chemotherapy drug) are commonly used. Targeted therapies like bevacizumab (an anti-VEGF monoclonal antibody) and immunotherapies such as pembrolizumab (an immune checkpoint inhibitor) may be prescribed for advanced or metastatic cases.

Prevalence: How common the health condition is within a specific population.
Small intestine cancer is very rare, representing less than 2% of all gastrointestinal cancers. Its incidence is estimated to be about 2-3 cases per 100,000 people per year.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Risk factors include genetic conditions such as Lynch syndrome, familial adenomatous polyposis (FAP), and Crohn's disease. Celiac disease and a history of radiation therapy to the abdomen also increase risk.

Prognosis: The expected outcome or course of the condition over time.
The prognosis depends on the stage of the cancer at diagnosis. For localized small intestine cancer, the 5-year survival rate can be as high as 80%, while for metastatic disease, the prognosis is much poorer, with a 5-year survival rate closer to 30%.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Potential complications include bowel obstruction, bleeding, malnutrition, and metastasis to the liver or lymph nodes. In some cases, the cancer can lead to the development of secondary tumors or complications from chemotherapy.

Peritoneal Mesothelioma

Specialty: Oncology

Category: Sarcomas

Sub-category: Rare Cancers

Symptoms:
abdominal pain; swelling in the abdomen; unexplained weight loss; nausea; vomiting; loss of appetite; fatigue; bloating; constipation

Root Cause:
Peritoneal mesothelioma is a rare cancer that affects the peritoneum, the lining of the abdomen. It is most commonly caused by asbestos exposure, which leads to the development of malignant cells that grow and invade the peritoneal lining.

How it's Diagnosed: videos
Diagnosis typically involves imaging studies such as CT scans, MRIs, or ultrasounds to detect fluid buildup (ascites) and tumors in the abdomen. A biopsy is needed for definitive diagnosis, often performed through laparoscopy or peritoneal biopsy.

Treatment:
Treatment options include surgery (e.g., cytoreductive surgery) to remove as much of the tumor as possible, often followed by heated chemotherapy (HIPEC) to target remaining cancer cells. Chemotherapy (e.g., pemetrexed and cisplatin) is used for advanced cases, and radiation therapy may also be applied.

Medications:
Common chemotherapy drugs used to treat peritoneal mesothelioma include pemetrexed (an antifolate drug) and cisplatin (a platinum-based chemotherapy agent). These are used in combination to help shrink tumors and manage the disease. In some cases, targeted therapies or immunotherapy may be considered.

Prevalence: How common the health condition is within a specific population.
Peritoneal mesothelioma is extremely rare, accounting for approximately 10-20% of all mesothelioma cases. The overall incidence is low, with an estimated 300-500 new cases diagnosed annually in the United States.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
The primary risk factor is exposure to asbestos, particularly in occupations like construction, shipbuilding, and manufacturing. Other risk factors include genetic mutations and a history of prior radiation exposure.

Prognosis: The expected outcome or course of the condition over time.
The prognosis for peritoneal mesothelioma is poor, with a median survival rate of 12-24 months, depending on the stage at diagnosis. Patients who undergo cytoreductive surgery with HIPEC may have improved outcomes, but survival is still limited.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Complications include bowel obstruction, ascites (fluid buildup in the abdomen), malnutrition, and metastasis to other parts of the body, particularly the lungs. The treatment itself can also cause side effects like fatigue, nausea, and immune suppression.

Extragonadal Germ Cell Tumors

Specialty: Oncology

Category: Sarcomas

Sub-category: Rare Cancers

Symptoms:
abdominal pain; swelling or mass; chest pain; coughing; shortness of breath; unexplained weight loss; fever; night sweats

Root Cause:
Extragonadal germ cell tumors (EGCTs) arise from germ cells that are typically found in the gonads (ovaries or testes) but develop in areas outside of these organs, such as the mediastinum, retroperitoneum, or pineal gland. These tumors are believed to be the result of abnormal migration of germ cells during fetal development.

How it's Diagnosed: videos
Diagnosis typically involves imaging techniques such as CT scans, MRIs, or chest X-rays to locate the tumor. Blood tests to measure tumor markers like alpha-fetoprotein (AFP) and human chorionic gonadotropin (hCG) are also used. A biopsy is necessary for histological confirmation.

Treatment:
Treatment for extragonadal germ cell tumors often involves a combination of surgery, chemotherapy, and sometimes radiation therapy. The standard chemotherapy regimen includes bleomycin, etoposide, and cisplatin (BEP). Surgery is used to remove the primary tumor when feasible.

Medications:
Chemotherapy agents such as bleomycin (an antibiotic used as a chemotherapy agent), etoposide (a plant alkaloid), and cisplatin (a platinum-based chemotherapy drug) are used to treat extragonadal germ cell tumors. These drugs are classified as alkylating agents, antimetabolites, and plant alkaloids , respectively.

Prevalence: How common the health condition is within a specific population.
Extragonadal germ cell tumors are rare, representing about 1-5% of all germ cell tumors. The incidence is lower than gonadal germ cell tumors, with approximately 2-3 cases per million people per year.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Risk factors include age (most common in adolescents and young adults), history of gonadal germ cell tumors, and certain genetic syndromes like Klinefelter syndrome. In rare cases, a family history of germ cell tumors or other related conditions may increase risk.

Prognosis: The expected outcome or course of the condition over time.
The prognosis for extragonadal germ cell tumors depends on the tumor's location, stage at diagnosis, and response to treatment. If caught early and treated aggressively, the 5-year survival rate can be around 70-90%, but survival rates drop significantly for metastatic or advanced disease.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Potential complications include metastasis to the lungs, liver, or other organs, recurrence after treatment, and side effects of chemotherapy such as organ toxicity (e.g., to the lungs or kidneys), fertility issues, and secondary cancers.

Hypercalcemia of Malignancy

Specialty: Oncology

Category: Sarcomas

Sub-category: Paraneoplastic Syndromes

Symptoms:
nausea; vomiting; constipation; abdominal pain; fatigue; confusion; thirst; frequent urination; muscle weakness

Root Cause:
Malignant tumors release calcium into the bloodstream, often through secretion of parathyroid hormone-related protein (PTHrP) or osteolytic bone metastasis.

How it's Diagnosed: videos
Blood tests showing elevated calcium levels, alongside confirmation of underlying malignancy through imaging or biopsy.

Treatment:
Hydration, bisphosphonates (such as zoledronic acid), denosumab, corticosteroids, and calcitonin.

Medications:
Bisphosphonates (e.g., zoledronic acid) inhibit bone resorption, and denosumab , a monoclonal antibody, works by inhibiting osteoclast activity. Corticosteroids (e.g., dexamethasone ) may be used if there is an underlying hematologic malignancy. Calcitonin helps to lower calcium levels by inhibiting osteoclast function.

Prevalence: How common the health condition is within a specific population.
Affects approximately 10-20% of patients with advanced cancer.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Patients with lung, breast, or hematologic cancers, and those with extensive bone metastasis.

Prognosis: The expected outcome or course of the condition over time.
The prognosis depends on the underlying malignancy and the ability to control calcium levels. Treatment of the underlying cancer can improve the prognosis.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Severe hypercalcemia can cause kidney failure, arrhythmias, coma, and, if untreated, death.

Graft-versus-Host Disease (GVHD) after Stem Cell Transplant

Specialty: Oncology

Category: Sarcomas

Sub-category: Treatment-Related Complications

Symptoms:
skin rashes; diarrhea; liver dysfunction; jaundice; dry mouth; fatigue; abdominal pain; fever

Root Cause:
The immune cells from the donor (graft) attack the recipient's tissues (host) after stem cell transplantation.

How it's Diagnosed: videos
Clinical evaluation, biopsy of affected tissue (skin, liver, or gastrointestinal tract), and blood tests for liver enzymes and other markers of inflammation.

Treatment:
Immunosuppressive therapy (e.g., corticosteroids), antithymocyte globulin, and other agents to suppress the immune response.

Medications:
Prednisone (a corticosteroid used to reduce inflammation and suppress the immune system), Mycophenolate mofetil (an immunosuppressive drug), and Tacrolimus (a calcineurin inhibitor). These medications are classified as immunosuppressants.

Prevalence: How common the health condition is within a specific population.
Around 30-70% of allogeneic stem cell transplant recipients experience some form of GVHD.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Donor-recipient mismatching, younger age of the recipient, and prior history of GVHD.

Prognosis: The expected outcome or course of the condition over time.
With early treatment, GVHD can often be controlled, but it can lead to chronic disability and even death in severe cases.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Chronic GVHD can affect multiple organs, including the skin, liver, and gastrointestinal tract, leading to long-term disability.

Arsine Poisoning

Specialty: Hematology

Category: Coagulation, Hemostasis, and Disorders

Symptoms:
dark red urine (hemoglobinuria); jaundice; fatigue; shortness of breath; nausea and vomiting; abdominal pain; weakness

Root Cause:
Hemolysis (destruction of red blood cells) caused by exposure to arsine gas, a highly toxic compound.

How it's Diagnosed: videos
Diagnosed through history of exposure, symptoms, and laboratory findings of hemolysis (elevated lactate dehydrogenase, low haptoglobin, and hemoglobinuria).

Treatment:
Remove the patient from exposure, supportive care, and blood transfusions for severe hemolysis.

Medications:
Chelating agents

Prevalence: How common the health condition is within a specific population.
Extremely rare; typically occurs in industrial settings with accidental exposure to arsine gas.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Working in industries handling arsenic compounds, such as semiconductor manufacturing or metallurgical processes.

Prognosis: The expected outcome or course of the condition over time.
Recovery is possible with prompt treatment, but severe cases may lead to kidney failure or death.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Acute kidney injury, severe anemia, multi-organ failure, and death if untreated.

Acute Intermittent Porphyria (AIP)

Specialty: Hematology

Category: Heme Synthesis and Disorders

Symptoms:
abdominal pain; nausea; vomiting; constipation; muscle weakness; confusion; anxiety; seizures; dark-colored urine

Root Cause:
Deficiency of the enzyme porphobilinogen deaminase (PBGD), leading to the accumulation of heme precursors such as delta-aminolevulinic acid (ALA) and porphobilinogen (PBG).

How it's Diagnosed: videos
Measurement of urinary porphobilinogen (PBG) levels during an acute attack; genetic testing to confirm enzyme mutations.

Treatment:
Avoiding triggers (e.g., certain drugs, fasting, stress), intravenous administration of hemin, high carbohydrate intake during attacks.

Medications:
Hemin (a heme analog used to suppress heme synthesis); glucose infusions for mild attacks to inhibit ALA synthase.

Prevalence: How common the health condition is within a specific population.
Affects approximately 1 in 20,000 individuals; more common in women than men.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Female sex, hormonal fluctuations, certain medications (e.g., barbiturates, sulfa drugs), fasting, alcohol consumption.

Prognosis: The expected outcome or course of the condition over time.
With proper management, acute attacks are treatable; however, untreated attacks can lead to complications.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Permanent neurological damage, chronic pain, liver cancer (in rare cases).

Hereditary Coproporphyria (HCP)

Specialty: Hematology

Category: Heme Synthesis and Disorders

Symptoms:
abdominal pain; nausea; vomiting; neuropathy; photosensitivity; dark urine

Root Cause:
Deficiency of the enzyme coproporphyrinogen oxidase, leading to the accumulation of porphyrins in the liver and plasma.

How it's Diagnosed: videos
Elevated levels of coproporphyrins in urine and stool; genetic testing.

Treatment:
Avoiding triggers, administration of hemin for acute attacks, high carbohydrate intake during symptomatic episodes.

Medications:
Hemin (to inhibit ALA synthase); glucose infusions for mild attacks.

Prevalence: How common the health condition is within a specific population.
Rare, with a prevalence of approximately 1 in 1,000,000.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Family history, hormonal changes, fasting, certain medications (e.g., sulfonamides).

Prognosis: The expected outcome or course of the condition over time.
Treatable; acute episodes can be effectively managed.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Neurological damage, chronic pain, photosensitivity-related skin damage.

Porphyria Overview

Specialty: Hematology

Category: Heme Synthesis and Disorders

Symptoms:
abdominal pain; neuropathy; photosensitivity; dark urine; fatigue

Root Cause:
Disorders caused by defects in heme biosynthesis enzymes, leading to the accumulation of porphyrins or their precursors.

How it's Diagnosed: videos
Biochemical analysis of urine, stool, and blood for porphyrins; genetic testing to identify specific mutations.

Treatment:
Symptom management, avoidance of triggers, hemin administration, high carbohydrate diets for acute attacks.

Medications:
Hemin (to control attacks); beta-carotene for photosensitivity.

Prevalence: How common the health condition is within a specific population.
Varies widely among types; AIP is most common, with a prevalence of 1 in 20,000.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Family history, environmental factors, hormonal fluctuations.

Prognosis: The expected outcome or course of the condition over time.
Varies by type; manageable with appropriate treatment.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Neuropathy, chronic pain, liver cancer (in severe cases).

Eosinophilia

Specialty: Hematology

Category: Immune System and Disorders

Symptoms:
fatigue; rash; itching; fever; shortness of breath; abdominal pain

Root Cause:
Elevated eosinophil count in the blood or tissues, often due to allergic reactions, parasitic infections, autoimmune diseases, or malignancies.

How it's Diagnosed: videos
Complete blood count (CBC) with differential, evaluation of medical history, imaging studies, and testing for parasitic or autoimmune causes.

Treatment:
Treatment focuses on addressing the underlying cause (e.g., treating infections, managing allergies, or suppressing immune responses).

Medications:
Corticosteroids (e.g., prednisone , to reduce inflammation), antihistamines (for allergic symptoms), and antiparasitic agents (e.g., albendazole , ivermectin , for parasitic infections). Biologics like mepolizumab may be used for refractory cases.

Prevalence: How common the health condition is within a specific population.
Varies; higher in areas with endemic parasitic infections. Often occurs in individuals with allergies or asthma.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Allergic disorders, parasitic infections, autoimmune diseases, exposure to certain medications (e.g., antibiotics, NSAIDs).

Prognosis: The expected outcome or course of the condition over time.
Depends on the underlying cause; manageable with appropriate treatment but may require ongoing monitoring for chronic or severe cases.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Organ damage (e.g., heart, lungs, skin) in cases of hypereosinophilic syndrome; increased risk of infections if associated with immune dysfunction.

Paroxysmal Cold Hemoglobinuria (PCH)

Specialty: Hematology

Category: Hemolytic Disorders

Sub-category: Autoimmune Hemolytic Anemias

Symptoms:
dark urine after cold exposure; fatigue; pallor; jaundice; fever; abdominal pain; back pain

Root Cause:
Autoimmune destruction of red blood cells triggered by cold exposure; mediated by Donath-Landsteiner antibodies.

How it's Diagnosed: videos
Donath-Landsteiner test (for biphasic hemolysis), CBC with evidence of hemolysis (low hemoglobin, high reticulocytes), and urine tests for hemoglobinuria.

Treatment:
Avoidance of cold exposure, supportive care (e.g., transfusions), and immunosuppressive therapy in severe cases.

Medications:
Corticosteroids (e.g., prednisone ), immunosuppressants (e.g., rituximab for refractory cases).

Prevalence: How common the health condition is within a specific population.
Rare; primarily affects children following viral infections.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Recent viral infection, cold exposure, autoimmune predisposition.

Prognosis: The expected outcome or course of the condition over time.
Generally good; self-limited in post-infectious cases, but may require treatment in chronic or severe cases.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Severe anemia, kidney damage due to hemoglobinuria.

Systemic Mastocytosis

Specialty: Hematology

Category: Mast Cell Disorders

Symptoms:
flushing; abdominal pain; diarrhea; anaphylaxis; bone pain; itching; skin lesions

Root Cause:
Abnormal proliferation and accumulation of mast cells in multiple organs, often driven by mutations like KIT D816V.

How it's Diagnosed: videos
Bone marrow biopsy, KIT mutation analysis, serum tryptase levels, and clinical presentation.

Treatment:
Symptom management (antihistamines, mast cell stabilizers), cytoreductive therapy for advanced cases.

Medications:
H1 and H2 antihistamines (e.g., loratadine , ranitidine), leukotriene inhibitors (e.g., montelukast ), and tyrosine kinase inhibitors (e.g., midostaurin for advanced cases).

Prevalence: How common the health condition is within a specific population.
Rare; incidence estimated at 1 in 10,000–20,000 individuals.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Genetic mutations (e.g., KIT D816V), familial mastocytosis.

Prognosis: The expected outcome or course of the condition over time.
Variable; indolent forms have a good prognosis, while aggressive forms may have significant morbidity and mortality.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Organ dysfunction, osteoporosis, anaphylaxis, and increased risk of secondary malignancies.

Paroxysmal Nocturnal Hemoglobinuria (PNH)

Specialty: Hematology

Category: Red Blood Cells and Disorders

Symptoms:
dark-colored urine (often in the morning); fatigue; weakness; shortness of breath; abdominal pain; difficulty swallowing; blood clots; jaundice

Root Cause:
A rare acquired mutation in the PIGA gene, leading to defective complement regulation on red blood cells and resulting in hemolysis (destruction of red blood cells).

How it's Diagnosed: videos
Flow cytometry detecting absent GPI-anchored proteins (e.g., CD55, CD59) on blood cells, lactate dehydrogenase (LDH) elevation, and hemoglobinuria.

Treatment:
Eculizumab (a complement inhibitor) is the main treatment. Supportive therapies include blood transfusions, iron supplementation, and anticoagulation for thrombosis.

Medications:
Eculizumab (Soliris ) — classified as a complement inhibitor, reduces hemolysis and thrombosis risk. Ravulizumab — a longer-acting complement inhibitor. Anticoagulants — used to prevent or treat thrombosis.

Prevalence: How common the health condition is within a specific population.
Rare; affects 1-2 per million people annually. More common in young adults and associated with aplastic anemia or bone marrow failure syndromes.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
genetic predisposition; association with aplastic anemia; exposure to certain toxins; immune dysregulation

Prognosis: The expected outcome or course of the condition over time.
Improved significantly with complement inhibitors; however, untreated cases have a high risk of thrombosis and early mortality.

Complications: Additional problems or conditions that may arise as a result of the original condition.
thrombosis; kidney failure; chronic hemolysis; iron overload from transfusions; pulmonary hypertension

Transfusion-Induced Iron Overload

Specialty: Hematology

Category: Red Blood Cells and Disorders

Symptoms:
fatigue; joint pain; darkened skin; abdominal pain; heart palpitations; shortness of breath

Root Cause:
Repeated blood transfusions lead to excessive iron accumulation in tissues, as the body cannot excrete the excess iron.

How it's Diagnosed: videos
Serum ferritin levels, transferrin saturation, liver MRI to assess iron deposition, and liver biopsy in certain cases.

Treatment:
Iron chelation therapy to remove excess iron and minimize organ damage. Lifestyle modifications, such as reducing dietary iron intake.

Medications:
Deferoxamine (parenteral), deferasirox (oral), and deferiprone (oral). These are classified as iron chelators.

Prevalence: How common the health condition is within a specific population.
Common in patients receiving chronic transfusions for conditions such as thalassemia, sickle cell disease, and myelodysplastic syndromes.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Frequent blood transfusions, hereditary hemochromatosis, ineffective erythropoiesis.

Prognosis: The expected outcome or course of the condition over time.
Good with early detection and treatment, but untreated cases can lead to significant organ damage.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Organ damage (heart, liver, pancreas), diabetes, cirrhosis, and heart failure.

AIDS-Related Lymphomas

Specialty: Hematology

Category: Immune System Disorders

Symptoms:
swollen lymph nodes; night sweats; fever; weight loss; fatigue; abdominal pain; chest pain or shortness of breath

Root Cause:
Immunosuppression from HIV/AIDS leading to the proliferation of malignant lymphocytes, often associated with Epstein-Barr Virus (EBV).

How it's Diagnosed: videos
Lymph node biopsy, imaging (CT, PET), blood tests, HIV viral load, and EBV testing.

Treatment:
Combination chemotherapy (e.g., CHOP regimen), antiretroviral therapy (ART) for HIV, and targeted therapies (e.g., rituximab).

Medications:
Rituximab (anti-CD20 monoclonal antibody), doxorubicin (anthracycline), vincristine , and prednisone (corticosteroid).

Prevalence: How common the health condition is within a specific population.
Increased risk in people with untreated HIV/AIDS; accounts for 3–5% of all non-Hodgkin lymphomas.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Advanced HIV, low CD4 counts, and co-infection with EBV.

Prognosis: The expected outcome or course of the condition over time.
Highly variable depending on HIV control and lymphoma type; overall 5-year survival ~30–50%.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Opportunistic infections, relapse, and progression to other AIDS-defining illnesses.

Mucosa-Associated Lymphoid Tissue Lymphomas (MALTomas)

Specialty: Hematology

Category: Stem Cells and Disorders

Symptoms:
abdominal pain; indigestion; weight loss; fatigue; anemia-related symptoms; lymphadenopathy in extranodal sites

Root Cause:
Low-grade B-cell lymphoma arising from mucosa-associated lymphoid tissue, often linked to chronic infections like Helicobacter pylori in the stomach.

How it's Diagnosed: videos
Biopsy of affected tissue, endoscopy for gastric cases, and molecular testing for genetic translocations (e.g., t(11;18)).

Treatment:
Antibiotic therapy for H. pylori-related cases, localized radiation, chemotherapy, or targeted therapy.

Medications:
Antibiotics (amoxicillin , clarithromycin ) for H. pylori; rituximab (anti-CD20 antibody) for systemic disease. These include anti-infective agents and monoclonal antibodies.

Prevalence: How common the health condition is within a specific population.
Rare, comprising 5–8% of non-Hodgkin lymphomas; most common in older adults.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Chronic infection with H. pylori or other pathogens, autoimmune conditions (e.g., Sjögren’s syndrome), and genetic abnormalities.

Prognosis: The expected outcome or course of the condition over time.
Excellent with early treatment; five-year survival exceeds 90% for localized disease.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Progression to high-grade lymphoma and organ dysfunction.

Wilson disease (ATP7B gene mutation)

Specialty: Genetics

Category: Single-Gene Disorders (Mendelian Inheritance)

Sub-category: Autosomal Recessive Disorders

Symptoms:
jaundice; abdominal pain; swelling in legs and abdomen; neurological symptoms like tremors or poor coordination; psychiatric symptoms; kayser-fleischer rings in the eyes

Root Cause:
Mutations in the ATP7B gene impair copper transport, leading to copper accumulation in the liver, brain, and other tissues.

How it's Diagnosed: videos
Serum ceruloplasmin levels, 24-hour urine copper test, liver biopsy, genetic testing for ATP7B mutations, slit-lamp exam for Kayser-Fleischer rings.

Treatment:
Copper-chelating agents, dietary modifications to reduce copper intake, and liver transplantation in severe cases.

Medications:
Penicillamine (chelates copper), trientine (alternative chelating agent), zinc acetate (reduces copper absorption).

Prevalence: How common the health condition is within a specific population.
Affects 1 in 30,000 to 1 in 40,000 individuals worldwide.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Family history; no specific demographic predisposition.

Prognosis: The expected outcome or course of the condition over time.
Good with early treatment; untreated cases result in severe liver and neurological damage.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Liver failure, neurological impairment, psychiatric disorders.

Familial adenomatous polyposis (APC gene mutation)

Specialty: Genetics

Category: Cancer Genetics

Sub-category: Hereditary Cancer Syndromes

Symptoms:
hundreds to thousands of colorectal polyps; blood in stool; abdominal pain; early-onset colorectal cancer

Root Cause:
APC gene mutations cause unregulated cell growth in the colon and rectum, leading to polyp formation.

How it's Diagnosed: videos
Genetic testing for APC mutations, colonoscopy to identify and biopsy polyps.

Treatment:
Prophylactic colectomy, regular colonoscopy, and chemoprevention with NSAIDs.

Medications:
NSAIDs like sulindac or celecoxib (classified as COX-2 inhibitors) may reduce polyp burden.

Prevalence: How common the health condition is within a specific population.
Affects 1 in 7,000–22,000 individuals.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Family history of FAP or APC mutation.

Prognosis: The expected outcome or course of the condition over time.
Excellent with early detection and management; untreated, nearly 100% risk of colorectal cancer by age 40.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Colorectal cancer, duodenal cancer, desmoid tumors, complications from surgery.

Multiple Endocrine Neoplasia (MEN)

Specialty: Genetics

Category: Genetic Contributions to Common Diseases

Sub-category: Endocrine Disorders

Symptoms:
hypercalcemia; diarrhea; abdominal pain; flushing; fatigue; palpitations; headaches; unintended weight changes; tumors in endocrine glands

Root Cause:
Caused by genetic mutations (e.g., MEN1, RET) leading to overgrowth of endocrine tissues, which form benign or malignant tumors.

How it's Diagnosed: videos
Blood tests (e.g., hormone levels such as calcium, PTH, or gastrin), imaging (MRI, CT), genetic testing for MEN1 or RET mutations, and family history analysis.

Treatment:
Surgical removal of tumors, monitoring hormone levels, symptomatic management, and targeted therapies for malignant cases.

Medications:
Medications include proton pump inhibitors (PPIs, e.g., omeprazole ) to reduce gastric acid secretion in Zollinger-Ellison syndrome and somatostatin analogs (e.g., octreotide ) for hormone-secreting tumors. Tyrosine kinase inhibitors (e.g., vandetanib ) may be used for medullary thyroid carcinoma.

Prevalence: How common the health condition is within a specific population.
Rare; MEN1 affects 1 in 30,000 people, while MEN2 affects about 1 in 35,000 people.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Family history of MEN mutations, autosomal dominant inheritance.

Prognosis: The expected outcome or course of the condition over time.
Varies by subtype and treatment; early detection and management improve outcomes, but malignant forms may have a poorer prognosis.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Cancer (e.g., medullary thyroid carcinoma, pancreatic neuroendocrine tumors), metastasis, organ damage due to hormonal overproduction, and recurrence of tumors.

Acetaminophen (Paracetamol) Toxicity

Specialty: Toxicology

Category: Acute Poisoning

Sub-category: Pharmaceutical Overdoses

Symptoms:
nausea; vomiting; abdominal pain; jaundice; confusion; fatigue

Root Cause:
Excessive intake of acetaminophen overwhelms liver detoxification pathways, leading to toxic accumulation of N-acetyl-p-benzoquinone imine (NAPQI), a metabolite that causes liver damage.

How it's Diagnosed: videos
Diagnosed with serum acetaminophen levels and liver function tests.

Treatment:
Treated with N-acetylcysteine (NAC) to replenish glutathione and prevent liver damage.

Medications:
N-acetylcysteine (NAC) is the antidote for acetaminophen toxicity. It belongs to the class of mucolytics and glutathione precursors.

Prevalence: How common the health condition is within a specific population.
Acetaminophen toxicity is one of the most common causes of acute liver failure globally, with thousands of cases reported annually.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Overdose (intentional or accidental), chronic alcohol use, malnutrition, or concurrent use of medications that induce cytochrome P450 enzymes (e.g., certain anticonvulsants).

Prognosis: The expected outcome or course of the condition over time.
Good if treated promptly; severe cases can lead to acute liver failure and death if untreated.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Acute liver failure, hepatic encephalopathy, kidney injury, and death in severe cases.

Methanol and ethylene glycol poisoning

Specialty: Toxicology

Category: Acute Poisoning

Sub-category: Chemical Poisoning

Symptoms:
nausea; vomiting; abdominal pain; blurred vision; seizures; altered mental status; metabolic acidosis; renal failure

Root Cause:
Toxic metabolites (formic acid from methanol, oxalate crystals from ethylene glycol) cause metabolic acidosis and organ damage (e.g., optic nerve in methanol poisoning, kidneys in ethylene glycol poisoning).

How it's Diagnosed: videos
Clinical history, elevated anion gap metabolic acidosis, osmolar gap, specific blood levels of methanol or ethylene glycol.

Treatment:
Administration of fomepizole or ethanol (inhibits alcohol dehydrogenase), bicarbonate therapy for acidosis, hemodialysis for severe cases, folinic acid or pyridoxine (cofactors to detoxify metabolites).

Medications:
Fomepizole (alcohol dehydrogenase inhibitor), ethanol (alternative alcohol dehydrogenase substrate), bicarbonate (neutralizes acidosis), folinic acid (enhances formic acid detoxification in methanol poisoning).

Prevalence: How common the health condition is within a specific population.
Sporadic cases, commonly associated with accidental ingestion or intentional poisoning.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Ingestion of antifreeze, windshield washer fluid, or contaminated alcohol.

Prognosis: The expected outcome or course of the condition over time.
Good with early treatment; delays can lead to permanent blindness or renal damage.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Blindness (methanol), renal failure (ethylene glycol), metabolic acidosis, multi-organ failure.

Isopropanol Poisoning

Specialty: Toxicology

Category: Acute Poisoning

Sub-category: Alcohol-Related Toxicity

Symptoms:
drowsiness; vomiting; abdominal pain; fruity breath odor; hypotension; coma; respiratory depression

Root Cause:
Central nervous system and gastrointestinal toxicity caused by ingestion or inhalation of isopropanol, metabolized to acetone.

How it's Diagnosed: videos
Clinical history, serum isopropanol levels, elevated osmolal gap, and acetone presence in blood or urine.

Treatment:
Supportive care, intravenous fluids, airway protection, hemodialysis in severe cases.

Medications:
No antidote is available ; management focuses on supportive care and hemodialysis for severe toxicity.

Prevalence: How common the health condition is within a specific population.
Rare; typically occurs due to accidental ingestion or intentional overdose.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Access to isopropanol (e.g., rubbing alcohol), substance misuse, occupational exposure.

Prognosis: The expected outcome or course of the condition over time.
Generally good with prompt supportive care; severe cases can result in respiratory or cardiovascular failure.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Hemorrhagic gastritis, hypotension, multi-organ failure.

Ethylene Glycol Poisoning

Specialty: Toxicology

Category: Acute Poisoning

Sub-category: Alcohol-Related Toxicity

Symptoms:
nausea; vomiting; abdominal pain; metabolic acidosis; seizures; kidney failure; coma

Root Cause:
Metabolism of ethylene glycol to toxic metabolites (glycolic acid, oxalic acid) causes metabolic acidosis, renal toxicity, and crystalluria.

How it's Diagnosed: videos
Elevated anion and osmolal gap, presence of calcium oxalate crystals in urine, serum ethylene glycol levels.

Treatment:
Fomepizole or ethanol to inhibit alcohol dehydrogenase, bicarbonate for acidosis, and hemodialysis for severe poisoning.

Medications:
Fomepizole or ethanol (alcohol dehydrogenase inhibitors); pyridoxine and thiamine may support metabolism.

Prevalence: How common the health condition is within a specific population.
Uncommon; typically involves accidental or intentional ingestion of antifreeze.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Access to ethylene glycol-containing products, substance misuse, occupational exposure.

Prognosis: The expected outcome or course of the condition over time.
Good with early treatment; delayed or untreated cases often result in severe renal damage or death.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Acute kidney injury, metabolic acidosis, neurological damage, death.

Lead Poisoning

Specialty: Toxicology

Category: Chronic Toxicity and Long-Term Exposures

Sub-category: Heavy Metal Toxicity

Symptoms:
abdominal pain; constipation; fatigue; irritability; headaches; memory problems; joint and muscle pain; developmental delays in children; anemia

Root Cause:
Accumulation of lead in the body due to exposure from sources like lead-based paints, contaminated water, or industrial emissions; lead interferes with numerous enzymatic processes and causes oxidative stress.

How it's Diagnosed: videos
Diagnosis is made through blood lead level (BLL) tests, typically measured in micrograms per deciliter (µg/dL). Levels above 5 µg/dL in children or adults warrant further evaluation.

Treatment:
Treatment includes identifying and removing the source of lead exposure, chelation therapy for high BLL, and supportive care for symptoms such as anemia.

Medications:
Chelation therapy medications include dimercaprol (a chelating agent), calcium disodium EDTA (a chelating agent for severe poisoning), and succimer (an oral chelating agent, also known as DMSA, for moderate cases).

Prevalence: How common the health condition is within a specific population.
Lead poisoning is more common in developing countries and affects millions globally, especially children in low-income households.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Exposure to lead-based paints, contaminated water (e.g., through lead pipes), industrial emissions, occupational exposure (e.g., smelting, battery manufacturing), and poor nutritional status (low calcium and iron intake).

Prognosis: The expected outcome or course of the condition over time.
Early diagnosis and removal of exposure sources can lead to significant improvement, but severe poisoning may result in permanent neurological and cognitive deficits, especially in children.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Long-term complications include developmental delays, learning disabilities, kidney damage, hypertension, and encephalopathy in severe cases.

Arsenic Poisoning

Specialty: Toxicology

Category: Chronic Toxicity and Long-Term Exposures

Sub-category: Heavy Metal Toxicity

Symptoms:
nausea; vomiting; abdominal pain; diarrhea; darkened skin patches; thickened skin on palms and soles; fatigue; peripheral neuropathy; confusion; muscle cramps

Root Cause:
Accumulation of arsenic in the body due to exposure to contaminated drinking water, industrial processes, or arsenic-containing pesticides. Arsenic disrupts cellular metabolism, DNA repair, and oxidative processes.

How it's Diagnosed: videos
Diagnosis is made through urine arsenic levels (preferred for recent exposure) or hair and nail analysis for chronic exposure. Clinical symptoms and exposure history are also key.

Treatment:
Treatment includes cessation of exposure, supportive care for symptoms, and chelation therapy for severe cases. Ensuring access to safe water sources is critical.

Medications:
Chelating agents such as dimercaprol and succimer (DMSA) are used to bind arsenic and enhance excretion. The choice of medication depends on the severity of poisoning.

Prevalence: How common the health condition is within a specific population.
Arsenic poisoning is prevalent in regions with contaminated groundwater, particularly in South Asia (e.g., Bangladesh, India) and parts of South America.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Drinking arsenic-contaminated water, occupational exposure (e.g., smelting, mining), use of arsenic-based pesticides, and ingestion of contaminated food.

Prognosis: The expected outcome or course of the condition over time.
Early intervention and cessation of exposure can lead to symptom improvement. However, prolonged exposure can result in irreversible damage and increased cancer risk.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Long-term complications include skin lesions, peripheral neuropathy, cardiovascular diseases, diabetes, and increased risks of cancers (e.g., skin, lung, bladder).

Cadmium Poisoning

Specialty: Toxicology

Category: Chronic Toxicity and Long-Term Exposures

Sub-category: Heavy Metal Toxicity

Symptoms:
nausea; vomiting; abdominal pain; diarrhea; shortness of breath; cough; weakness; bone pain; renal dysfunction (proteinuria); osteomalacia

Root Cause:
Cadmium exposure occurs primarily through inhalation of fumes or dust (e.g., in industrial settings) or ingestion of contaminated food or water. Cadmium accumulates in the kidneys and bones, leading to oxidative stress, cellular damage, and impaired calcium metabolism.

How it's Diagnosed: videos
Diagnosis is made by measuring cadmium levels in blood or urine. Renal function tests (e.g., urinary protein levels) and bone density studies are often conducted to assess long-term damage.

Treatment:
Treatment includes removing the source of cadmium exposure, supportive care for symptoms, and chelation therapy in severe cases. Calcium and vitamin D supplementation may be recommended for bone health.

Medications:
Chelating agents like dimercaprol and EDTA (ethylenediaminetetraacetic acid) may be used in cases of severe poisoning. Chelation is less effective for chronic exposure due to cadmium's strong tissue binding.

Prevalence: How common the health condition is within a specific population.
Cadmium poisoning is more common in industrial workers (e.g., battery manufacturing, metal plating) and populations exposed to contaminated food or water, particularly in areas with poor environmental regulations.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Occupational exposure (e.g., smelting, welding), smoking (tobacco contains cadmium), consumption of cadmium-contaminated food (e.g., rice, shellfish), and living near industrial sites.

Prognosis: The expected outcome or course of the condition over time.
Early removal from exposure can improve outcomes, but chronic exposure may result in irreversible kidney damage, bone demineralization, and other complications.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Long-term complications include chronic kidney disease (CKD), osteoporosis, fractures, respiratory disorders (e.g., emphysema), and an increased risk of cancers (e.g., lung, prostate).

Chromium Toxicity

Specialty: Toxicology

Category: Chronic Toxicity and Long-Term Exposures

Sub-category: Heavy Metal Toxicity

Symptoms:
skin ulcers; rash; respiratory issues (cough, wheezing); abdominal pain; nausea; vomiting; fatigue; headaches; cognitive impairment; kidney damage; liver dysfunction

Root Cause:
Chromium toxicity occurs through inhalation of chromium-containing dust or fumes (commonly in industrial settings), or ingestion of contaminated food or water. Chromium (especially hexavalent chromium) is a potent carcinogen and irritates tissues, leading to cellular and organ damage.

How it's Diagnosed: videos
Diagnosis is based on measuring chromium levels in urine, blood, or sputum. Occupational history and clinical symptoms are key, particularly in those with chronic exposure.

Treatment:
Treatment involves removal from exposure, supportive care for symptoms, and possible chelation therapy for high chromium levels. Bronchodilators may be used for respiratory symptoms.

Medications:
Chelating agents like dimercaprol, EDTA, and penicillamine can be used to help remove chromium from the body in cases of severe poisoning. However, chromium toxicity primarily requires supportive management and removal of the exposure source.

Prevalence: How common the health condition is within a specific population.
Chromium toxicity is more common in individuals working in industries like metal plating, welding, and leather tanning, as well as those exposed to contaminated water sources.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Occupational exposure (e.g., metal plating, cement production, leather tanning), environmental contamination, living near industrial sites, and consuming water contaminated with hexavalent chromium.

Prognosis: The expected outcome or course of the condition over time.
The prognosis depends on the severity of exposure and the timeliness of medical intervention. Chronic exposure can lead to irreversible lung damage, kidney failure, and an increased risk of cancer.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Long-term complications include respiratory diseases (e.g., lung cancer, asthma), kidney and liver damage, skin ulcers, and gastrointestinal issues. Chronic exposure may also lead to an increased risk of cancers, particularly lung and gastrointestinal cancers.

Ricin poisoning (castor bean plant)

Specialty: Toxicology

Category: Biological and Natural Toxins

Sub-category: Plant Toxins

Symptoms:
nausea; vomiting; diarrhea; abdominal pain; severe dehydration; organ failure; difficulty breathing (if inhaled); seizures

Root Cause:
Ricin is a highly toxic protein that inhibits protein synthesis at the cellular level, causing cell death and widespread tissue damage.

How it's Diagnosed: videos
Clinical history of exposure (e.g., ingestion, inhalation, or injection of castor beans); confirmed with laboratory tests for ricin in blood, urine, or environmental samples.

Treatment:
Supportive care (IV fluids, mechanical ventilation for respiratory distress, medications to manage organ failure), decontamination (activated charcoal for ingestion), and symptomatic treatment.

Medications:
No specific antidote exists for ricin. Supportive treatments may include anti-seizure medications (benzodiazepines like lorazepam ), anti-inflammatory drugs, and oxygen therapy.

Prevalence: How common the health condition is within a specific population.
Rare; typically associated with accidental ingestion or intentional poisoning.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Handling or ingesting castor beans, occupational exposure (e.g., castor oil production).

Prognosis: The expected outcome or course of the condition over time.
Depends on dose and route of exposure; severe cases without prompt treatment can be fatal. Survival is possible with early supportive care.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Respiratory failure, kidney failure, multi-organ dysfunction, death in severe cases.

Foxglove (digitalis) toxicity

Specialty: Toxicology

Category: Biological and Natural Toxins

Sub-category: Plant Toxins

Symptoms:
nausea; vomiting; diarrhea; abdominal pain; confusion; visual disturbances (e.g., seeing halos around lights); irregular heart rhythms

Root Cause:
Digitalis compounds interfere with sodium-potassium ATPase in cardiac cells, leading to increased intracellular calcium and altered heart function.

How it's Diagnosed: videos
Clinical presentation, history of foxglove exposure or ingestion, and elevated serum digoxin levels.

Treatment:
Activated charcoal (if ingestion is recent), digoxin-specific antibody fragments (Digibind), and management of arrhythmias (e.g., with anti-arrhythmic drugs or temporary pacing).

Medications:
Digibind (digoxin-specific antibody fragments); anti-arrhythmics like lidocaine may be used for ventricular arrhythmias.

Prevalence: How common the health condition is within a specific population.
Rare in modern contexts; usually due to accidental ingestion or misuse of foxglove extracts.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Accidental ingestion, herbal remedy misuse, or overdose of digoxin-containing medications.

Prognosis: The expected outcome or course of the condition over time.
Good with early recognition and treatment; severe cases can be life-threatening.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Life-threatening arrhythmias, cardiac arrest, neurological complications (e.g., seizures).

Mycotoxin exposure (e.g., aflatoxins from mold)

Specialty: Toxicology

Category: Biological and Natural Toxins

Sub-category: Bacterial and Fungal Toxins

Symptoms:
nausea; vomiting; abdominal pain; fatigue; jaundice; liver damage; immunosuppression

Root Cause:
Mycotoxins, such as aflatoxins produced by molds (Aspergillus species), can contaminate food and cause toxic effects, especially on the liver.

How it's Diagnosed: videos
Diagnosis involves testing food or body fluids (e.g., urine, blood) for the presence of specific mycotoxins. Liver function tests may show signs of damage.

Treatment:
There is no specific antidote for mycotoxin poisoning. Treatment is supportive and involves addressing liver damage, detoxification, and managing symptoms.

Medications:
"Activated charcoal " (used in the treatment of poisonings, classified as an adsorbent to prevent toxin absorption), "liver protectants" (such as silymarin or N-acetylcysteine), "antioxidants" (to reduce oxidative damage).

Prevalence: How common the health condition is within a specific population.
Aflatoxins affect millions of people globally, especially in developing countries with poor agricultural practices, with exposure often through contaminated food like peanuts, maize, and grains.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Poor food storage, high humidity, warm temperatures, and poor agricultural practices leading to fungal contamination.

Prognosis: The expected outcome or course of the condition over time.
Long-term exposure to mycotoxins can lead to chronic liver damage, including cirrhosis and liver cancer, but acute poisoning may resolve with supportive care.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Chronic liver disease, immunosuppression, increased risk of liver cancer, and death in severe cases.

Ciguatera Fish Poisoning

Specialty: Toxicology

Category: Biological and Natural Toxins

Sub-category: Foodborne and Natural Toxins

Symptoms:
nausea; vomiting; diarrhea; abdominal pain; muscle weakness; numbness; tingling in limbs; temperature reversal (cold objects feel hot, and hot objects feel cold); fatigue

Root Cause:
Toxins (ciguatoxins) produced by marine dinoflagellates accumulate in certain fish species, causing symptoms after ingestion.

How it's Diagnosed: videos
Diagnosis is primarily clinical, based on history of fish consumption and characteristic symptoms. Confirmation is difficult, but urine or blood tests may detect ciguatoxins, though they are not routinely available.

Treatment:
Treatment is supportive, including hydration, pain management, and anti-nausea medications. There is no specific antidote for ciguatera poisoning.

Medications:
Symptomatic medications may include antihistamines, antiemetics (e.g., ondansetron ), and analgesics for pain relief (e.g., acetaminophen or ibuprofen ). In severe cases, intravenous fluids may be required. Some case reports suggest using mannitol (a diuretic) for neurological symptoms, though this is controversial.

Prevalence: How common the health condition is within a specific population.
Ciguatera poisoning is more common in tropical and subtropical regions, especially in the Pacific Islands, Caribbean, and coastal areas of Southeast Asia.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Consumption of large reef fish (e.g., barracuda, grouper, snapper), especially from tropical or subtropical waters.

Prognosis: The expected outcome or course of the condition over time.
Most people recover fully within weeks to months, but some may experience persistent neurological symptoms (e.g., temperature reversal) for months or years.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Long-term neurological effects, such as persistent numbness, tingling, and temperature sensation reversal. Rare cases may have cardiovascular complications such as arrhythmias.

Amanita Mushroom Poisoning

Specialty: Toxicology

Category: Biological and Natural Toxins

Sub-category: Foodborne and Natural Toxins

Symptoms:
nausea; vomiting; abdominal pain; diarrhea; jaundice; liver failure; renal failure; confusion; seizures

Root Cause:
The ingestion of Amanita mushrooms, especially species like Amanita phalloides (death cap), which contain potent toxins (amatoxins) that damage the liver and kidneys.

How it's Diagnosed: videos
Diagnosis is based on clinical history (ingestion of suspected mushrooms), clinical symptoms, and laboratory tests (e.g., liver function tests, mushroom identification). Detection of amatoxins in urine may confirm diagnosis.

Treatment:
Treatment involves supportive care (e.g., intravenous fluids, liver dialysis), and in severe cases, liver transplantation may be required. Antidotes like silibinin (milk thistle extract) and N-acetylcysteine may help.

Medications:
Antidotes such as silibinin (a liver protectant) and N-acetylcysteine (used for liver support) may be prescribed. In some cases, activated charcoal is used if the mushroom was ingested recently.

Prevalence: How common the health condition is within a specific population.
Amanita mushroom poisoning is rare but serious, often occurring during the mushroom-picking season, typically in temperate climates.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Mushroom foraging, especially by individuals who may confuse toxic species with edible ones. Lack of mushroom identification expertise.

Prognosis: The expected outcome or course of the condition over time.
If treated early, the prognosis may be improved. However, poisoning can lead to severe liver and kidney damage or death if not addressed promptly.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Liver failure, renal failure, long-term organ damage, and death in severe cases.

Herbicide Toxicity (e.g., Glyphosate)

Specialty: Toxicology

Category: Toxic Effects of Environmental Pollutants

Sub-category: Soil and Agricultural Toxins

Symptoms:
skin irritation; burning sensation in the throat; difficulty breathing; nausea; vomiting; abdominal pain; diarrhea

Root Cause:
Exposure to herbicides like glyphosate causes cellular damage through oxidative stress and disruption of enzyme systems critical for normal physiological function. Ingestion of concentrated formulations may lead to corrosive injury.

How it's Diagnosed: videos
Diagnosed through patient history, clinical presentation, and laboratory tests to detect glyphosate or its metabolites in blood or urine. Imaging studies may assess organ damage in severe cases.

Treatment:
Supportive care includes decontamination (removal of contaminated clothing, washing skin), gastric lavage for ingestion, intravenous fluids, and monitoring of respiratory and renal function. Activated charcoal may be administered to reduce absorption.

Medications:
No specific antidote is available . Symptomatic treatments include antiemetics (e.g., ondansetron ), proton pump inhibitors (e.g., omeprazole ) to reduce gastric irritation, and analgesics (e.g., acetaminophen ) for pain relief. Dialysis may be required for renal failure.

Prevalence: How common the health condition is within a specific population.
Herbicide exposure is common in agricultural communities and areas where herbicides are heavily used. Glyphosate is one of the most widely used herbicides globally. Accidental or occupational exposure affects thousands annually.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Occupational exposure, improper handling or storage of herbicides, lack of protective equipment during application, accidental ingestion, and contamination of drinking water or food.

Prognosis: The expected outcome or course of the condition over time.
Mild exposure typically resolves with supportive care. Severe exposure can lead to life-threatening complications but has a favorable prognosis with timely medical intervention.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Acute toxicity may cause corrosive injuries to the gastrointestinal tract, respiratory failure, renal impairment, and, in severe cases, cardiovascular collapse. Chronic exposure is associated with an increased risk of cancer, endocrine disruption, and developmental issues.

Porphyria-related toxicity

Specialty: Toxicology

Category: Endogenous Toxins

Sub-category: Hematologic Disorders

Symptoms:
abdominal pain; nausea; vomiting; constipation; dark urine; seizures; muscle weakness; anxiety; hallucinations

Root Cause:
Accumulation of porphyrins or their precursors due to a defect in the heme biosynthesis pathway, leading to neurotoxicity and other systemic effects.

How it's Diagnosed: videos
Urine and blood tests for porphyrins and precursors (e.g., aminolevulinic acid, porphobilinogen); genetic testing to identify specific mutations.

Treatment:
Glucose infusions or hemin administration to suppress heme biosynthesis, along with supportive care to manage symptoms. Avoidance of triggering factors such as certain medications or fasting.

Medications:
Hemin (synthetic heme, used to downregulate porphyrin production), glucose (for metabolic support).

Prevalence: How common the health condition is within a specific population.
Rare, with an estimated prevalence of 1 in 25,000 to 1 in 50,000 for acute porphyrias.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Family history, use of triggering medications (e.g., barbiturates, sulfonamides), alcohol consumption, hormonal changes (e.g., during menstruation).

Prognosis: The expected outcome or course of the condition over time.
With early diagnosis and management, symptoms are reversible, but severe attacks can lead to long-term complications or death.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Chronic pain, paralysis, kidney failure, liver damage, severe neurological deficits.

Suicide attempts via pharmaceutical or chemical agents

Specialty: Toxicology

Category: Deliberate and Accidental Poisoning

Sub-category: Intentional Overdoses

Symptoms:
altered mental status; respiratory depression; seizures; nausea; vomiting; abdominal pain; cardiac arrhythmias; coma

Root Cause:
Ingestion of toxic doses of medications (e.g., sedatives, opioids, antidepressants) or chemicals (e.g., household cleaners, industrial substances) causes systemic toxicity and organ dysfunction.

How it's Diagnosed: videos
Clinical history (when available), physical examination, toxicology screens (blood and urine), serum drug levels, and imaging studies (if structural damage is suspected).

Treatment:
Stabilization (airway, breathing, circulation), decontamination (e.g., activated charcoal if appropriate), specific antidotes (e.g., naloxone for opioids), symptomatic management (e.g., anti-seizure medications), and supportive care (e.g., IV fluids, mechanical ventilation).

Medications:
Antidotes such as naloxone (opioid antagonist), flumazenil (benzodiazepine antagonist), and N-acetylcysteine (for acetaminophen overdose); sedatives like benzodiazepines (anticonvulsants) for seizures; and IV fluids for dehydration and hypotension.

Prevalence: How common the health condition is within a specific population.
Suicide attempts via pharmaceutical or chemical agents account for approximately 10-20% of emergency toxicology cases worldwide, with variations depending on region and accessibility to medications or chemicals.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
History of mental health disorders (e.g., depression, anxiety), access to toxic substances, substance abuse, prior suicide attempts, and social stressors.

Prognosis: The expected outcome or course of the condition over time.
Prognosis depends on the type and amount of substance ingested, time to treatment, and overall health of the individual. With timely intervention, most cases are survivable. Delayed or inadequate treatment may lead to significant morbidity or mortality.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Organ failure (e.g., liver or kidney damage), aspiration pneumonia, prolonged hospital stays, chronic neurological deficits, and death.

Pediatric ingestions (e.g., iron supplements, cleaning agents)

Specialty: Toxicology

Category: Deliberate and Accidental Poisoning

Sub-category: Accidental Poisoning

Symptoms:
vomiting; abdominal pain; diarrhea; lethargy; seizures; respiratory distress; shock

Root Cause:
Accidental ingestion of toxic substances like medications, cleaning agents, or chemicals due to lack of proper storage or childproofing.

How it's Diagnosed: videos
Based on clinical history, symptoms, and laboratory tests, including blood levels of suspected toxins (e.g., serum iron levels, blood gas analysis).

Treatment:
Decontamination (e.g., activated charcoal), supportive care, specific antidotes if applicable (e.g., deferoxamine for iron toxicity).

Medications:
Antidotes such as deferoxamine (iron chelator), IV fluids for hydration, and antiemetics for symptom control. Deferoxamine is classified as an iron-chelating agent.

Prevalence: How common the health condition is within a specific population.
A common cause of pediatric emergency visits; exact prevalence depends on local safety measures and poisoning prevention efforts.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Lack of childproof containers, improper storage of medications or chemicals, inadequate supervision, high accessibility of toxic substances.

Prognosis: The expected outcome or course of the condition over time.
Good with prompt intervention, though severe cases (e.g., iron toxicity) can lead to long-term organ damage or death.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Organ failure (e.g., liver failure), metabolic acidosis, gastrointestinal damage, seizures, death.

Heavy metal contamination in traditional remedies

Specialty: Toxicology

Category: Miscellaneous Toxicological Conditions

Sub-category: Herbal and Alternative Medicine Toxicity

Symptoms:
abdominal pain; nausea; vomiting; diarrhea; headache; fatigue; cognitive impairment; kidney dysfunction; anemia; peripheral neuropathy

Root Cause:
Presence of toxic heavy metals (e.g., lead, mercury, arsenic, cadmium) in traditional or alternative remedies due to contamination or intentional adulteration during manufacturing.

How it's Diagnosed: videos
Blood and urine tests to detect heavy metal levels; clinical history of remedy use; imaging or organ function tests for damage assessment.

Treatment:
Immediate discontinuation of the remedy; chelation therapy for heavy metal removal; supportive care for symptoms and organ damage management.

Medications:
Chelating agents such as dimercaprol (a chelating agent for arsenic , mercury, and lead poisoning), succimer (an oral chelator for lead poisoning), and calcium disodium EDTA (used for lead chelation therapy).

Prevalence: How common the health condition is within a specific population.
Prevalence varies geographically but is significant in regions with widespread use of unregulated traditional remedies.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Use of imported or locally made traditional remedies, lack of regulatory oversight, cultural reliance on alternative medicine, and socioeconomic factors limiting access to conventional healthcare.

Prognosis: The expected outcome or course of the condition over time.
Prognosis depends on the level and duration of exposure; early intervention improves outcomes, while delayed treatment may lead to irreversible organ damage or chronic health issues.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Chronic kidney disease, neurotoxicity, developmental delays in children, anemia, cardiovascular issues, and increased cancer risk (e.g., arsenic-related carcinogenesis).

Bacteroides Infection

Specialty: Infectious Diseases

Category: Bacterial Infections

Symptoms:
abdominal pain; fever; abscess formation; diarrhea; foul-smelling discharge; skin infections

Root Cause:
Infection caused by Bacteroides species, obligate anaerobic bacteria commonly found in the gastrointestinal tract.

How it's Diagnosed: videos
Culture and sensitivity testing of infected tissue or fluids; imaging to detect abscesses.

Treatment:
Drainage of abscesses, surgical debridement, and targeted antibiotic therapy.

Medications:
Metronidazole (nitroimidazole), clindamycin (lincosamide), or beta-lactam/beta-lactamase inhibitors like amoxicillin-clavulanate.

Prevalence: How common the health condition is within a specific population.
Common in intra-abdominal infections, post-surgical infections, and pelvic inflammatory disease.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Abdominal surgery, trauma, or conditions causing gastrointestinal perforation.

Prognosis: The expected outcome or course of the condition over time.
Good with prompt treatment; untreated infections can be life-threatening.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Abscess formation, systemic spread (bacteremia), and chronic infections.

Campylobacter Infections

Specialty: Infectious Diseases

Category: Bacterial Infections

Symptoms:
diarrhea; abdominal pain; fever; nausea; vomiting

Root Cause:
Caused by Campylobacter jejuni or Campylobacter coli, often through contaminated food or water, leading to gastrointestinal inflammation.

How it's Diagnosed: videos
Stool cultures, molecular assays, and antigen tests.

Treatment:
Supportive care for mild cases; antibiotics for severe cases or immunocompromised patients.

Medications:
Azithromycin (macrolide antibiotic) or ciprofloxacin (fluoroquinolone antibiotic).

Prevalence: How common the health condition is within a specific population.
One of the most common causes of bacterial diarrhea worldwide, with an estimated 96 million cases annually.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Consumption of undercooked poultry, unpasteurized milk, contaminated water, and international travel.

Prognosis: The expected outcome or course of the condition over time.
Usually self-limiting within a week; antibiotics hasten recovery in severe cases.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Guillain-Barré syndrome, reactive arthritis, and bloodstream infections.

Group D Streptococcus (GDS) Infections

Specialty: Infectious Diseases

Category: Bacterial Infections

Symptoms:
fever; fatigue; abdominal pain; blood in stool; endocarditis symptoms (e.g., heart murmur); weight loss

Root Cause:
Caused by Streptococcus bovis or Streptococcus gallolyticus bacteria, often linked to colorectal cancer or endocarditis.

How it's Diagnosed: videos
Blood cultures, echocardiography (for endocarditis), and colonoscopy to screen for associated colorectal malignancy.

Treatment:
Prolonged antibiotic therapy; surgical intervention may be required for complications like valve damage.

Medications:
Penicillin G or ceftriaxone (a cephalosporin) for active infections. Vancomycin may be used for beta-lactam allergies.

Prevalence: How common the health condition is within a specific population.
Rare compared to other streptococcal infections; associated with 15–65% of colorectal cancer cases.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Age over 50, colorectal malignancies, valvular heart disease, or immunocompromised conditions.

Prognosis: The expected outcome or course of the condition over time.
Good with appropriate antibiotic treatment. However, prognosis may depend on the underlying colorectal malignancy or cardiac condition.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Endocarditis, septicemia, and undiagnosed colorectal cancer.

Helicobacter Pylori Infection

Specialty: Infectious Diseases

Category: Gastrointestinal Tract and Intra-abdominal Infections

Symptoms:
abdominal pain; nausea; vomiting; bloating; loss of appetite; unintentional weight loss; dark or tarry stools (indicating bleeding)

Root Cause:
Chronic infection caused by Helicobacter pylori bacteria, leading to inflammation of the stomach lining and increased risk of peptic ulcers and gastric cancer.

How it's Diagnosed: videos
Urea breath test, stool antigen test, blood test for antibodies, endoscopy with biopsy.

Treatment:
Combination of antibiotics to eradicate the bacteria and proton pump inhibitors (PPIs) to reduce stomach acid.

Medications:
Antibiotics (e.g., amoxicillin , clarithromycin , metronidazole ) to kill the bacteria. Proton pump inhibitors (PPIs, e.g., omeprazole , lansoprazole ) to reduce stomach acid and promote healing. Bismuth subsalicylate (part of quadruple therapy) to protect the stomach lining.

Prevalence: How common the health condition is within a specific population.
Affects approximately 50% of the global population; more common in developing countries due to poor sanitation.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Poor sanitation, contaminated food and water, close contact with an infected individual, family history of H. pylori infection.

Prognosis: The expected outcome or course of the condition over time.
Eradication is successful in most cases with appropriate therapy; untreated infections can lead to complications like ulcers or gastric cancer.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Peptic ulcers, gastric cancer, chronic gastritis, iron-deficiency anemia.

Klebsiella Infections

Specialty: Infectious Diseases

Category: Bacterial Infections

Symptoms:
fever; cough with thick sputum; shortness of breath; abdominal pain; urinary symptoms; chills; fatigue

Root Cause:
Infections caused by Klebsiella species, primarily Klebsiella pneumoniae, leading to pneumonia, urinary tract infections, sepsis, and liver abscesses.

How it's Diagnosed: videos
Blood cultures, sputum cultures, urine cultures, imaging (chest X-ray, CT scan) for pneumonia or abscesses.

Treatment:
Targeted antibiotic therapy based on susceptibility testing; supportive care for severe infections.

Medications:
Carbapenems (e.g., meropenem or imipenem ) for multidrug-resistant strains; cephalosporins (e.g., ceftriaxone ) or fluoroquinolones (e.g., ciprofloxacin ) for susceptible strains. Colistin or tigecycline for extensively drug-resistant strains.

Prevalence: How common the health condition is within a specific population.
Increasing incidence due to antibiotic resistance, particularly in healthcare settings.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Hospitalization, use of invasive devices (e.g., catheters), immunosuppression, diabetes, chronic lung disease.

Prognosis: The expected outcome or course of the condition over time.
Varies; good with early diagnosis and appropriate treatment, but mortality rates are high in severe, resistant infections.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Septic shock, lung abscesses, liver abscesses, and antibiotic resistance.

Leptospirosis

Specialty: Infectious Diseases

Category: Bacterial Infections

Symptoms:
high fever; muscle pain; headache; vomiting; jaundice; red eyes; skin rash; abdominal pain

Root Cause:
Caused by infection with Leptospira species, transmitted through water contaminated by animal urine, often affecting the liver, kidneys, and lungs.

How it's Diagnosed: videos
Serology (e.g., microscopic agglutination test), polymerase chain reaction (PCR), or culture from blood, urine, or cerebrospinal fluid.

Treatment:
Antibiotics to clear the infection, supportive care for organ involvement, and management of complications such as kidney failure.

Medications:
Doxycycline or penicillin (for mild cases); intravenous ceftriaxone or penicillin G for severe cases.

Prevalence: How common the health condition is within a specific population.
Common in tropical and subtropical regions, particularly after heavy rainfall or flooding.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Exposure to contaminated water, working with animals, poor sanitation, recreational water activities.

Prognosis: The expected outcome or course of the condition over time.
Good with early treatment; severe cases (Weil's disease) have a higher risk of mortality.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Kidney damage, meningitis, liver failure, respiratory distress, and hemorrhage.

Proteus Infections

Specialty: Infectious Diseases

Category: Bacterial Infections

Symptoms:
urinary tract infections (utis); fever; painful urination; abdominal pain; foul-smelling urine; wound infections; sepsis in severe cases

Root Cause:
Caused by the Proteus species, a genus of Gram-negative bacteria. Commonly associated with UTIs and hospital-acquired infections due to its ability to produce urease and form biofilms.

How it's Diagnosed: videos
Urine culture, blood culture, or wound culture; imaging (e.g., ultrasound or CT for abscesses or stones); antimicrobial susceptibility testing to identify effective antibiotics.

Treatment:
Antibiotic therapy based on culture sensitivity results; supportive care if systemic infection occurs; removal of infected devices or stones if present.

Medications:
Commonly prescribed antibiotics include ceftriaxone (third-generation cephalosporin), piperacillin-tazobactam (beta-lactam/beta-lactamase inhibitor), or ciprofloxacin (fluoroquinolone) for sensitive strains. Aminoglycosides like gentamicin may also be used for severe cases.

Prevalence: How common the health condition is within a specific population.
Proteus infections are a common cause of hospital-acquired infections and account for 1-2% of community-acquired UTIs.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Indwelling catheters, immunosuppression, prolonged hospitalization, structural abnormalities of the urinary tract, previous antibiotic use.

Prognosis: The expected outcome or course of the condition over time.
Good with prompt diagnosis and appropriate treatment. However, delays or resistance to treatment can lead to complications such as kidney stones, chronic infections, or sepsis.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Struvite stone formation, recurrent UTIs, abscesses, and sepsis.

Providencia Infections

Specialty: Infectious Diseases

Category: Bacterial Infections

Symptoms:
utis; fever; abdominal pain; burn wound infections; sepsis in immunocompromised patients

Root Cause:
Caused by Providencia species, Gram-negative bacteria with resistance to multiple antibiotics. Common in nosocomial infections and associated with biofilm formation.

How it's Diagnosed: videos
Urine, blood, or wound cultures; antimicrobial sensitivity testing.

Treatment:
Treatment with targeted antibiotics based on susceptibility results; removal of infected devices or management of underlying conditions.

Medications:
Effective antibiotics may include imipenem (carbapenem), amikacin (aminoglycoside), or cefepime (fourth-generation cephalosporin), depending on susceptibility.

Prevalence: How common the health condition is within a specific population.
Rare but increasingly identified in healthcare-associated infections, especially in patients with urinary catheters.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Immunosuppression, long-term catheter use, extended hospital stays, prior antibiotic use.

Prognosis: The expected outcome or course of the condition over time.
Can be challenging to treat due to multidrug resistance but favorable outcomes with appropriate antibiotic therapy.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Persistent UTIs, systemic infection, multi-organ failure in severe cases.

Pseudotuberculosis

Specialty: Infectious Diseases

Category: Bacterial Infections

Symptoms:
fever; abdominal pain; diarrhea; mesenteric lymphadenitis mimicking appendicitis

Root Cause:
Caused by Yersinia pseudotuberculosis, a Gram-negative bacterium that primarily affects the gastrointestinal tract.

How it's Diagnosed: videos
Stool culture, blood culture, or serological testing.

Treatment:
Antibiotics for severe infections; supportive care for mild cases.

Medications:
Doxycycline (tetracycline ) or trimethoprim-sulfamethoxazole (sulfonamide) for systemic cases.

Prevalence: How common the health condition is within a specific population.
Rare, with sporadic outbreaks often linked to contaminated food or water.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Consumption of contaminated food, exposure to infected animals, underlying immunodeficiency.

Prognosis: The expected outcome or course of the condition over time.
Excellent for uncomplicated cases with supportive care. Severe cases respond well to antibiotic therapy.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Reactive arthritis, septicemia, and erythema nodosum.

Spontaneous Bacterial Peritonitis (SBP)

Specialty: Infectious Diseases

Category: Bacterial Infections

Symptoms:
fever; abdominal pain; nausea; vomiting; altered mental status; diarrhea; low blood pressure; tachycardia

Root Cause:
Infection of the peritoneal fluid in patients with cirrhosis and ascites, often due to bacterial translocation from the gut.

How it's Diagnosed: videos
Diagnostic paracentesis showing ascitic fluid with polymorphonuclear leukocytes (PMN) >250 cells/mm³, positive bacterial cultures, and low protein levels in ascitic fluid.

Treatment:
Antibiotics, supportive care, and management of the underlying cirrhosis or liver disease.

Medications:
Empiric therapy typically includes third-generation cephalosporins (e.g., cefotaxime or ceftriaxone ). Fluoroquinolones (e.g., ciprofloxacin ) may be used for prophylaxis in high-risk patients.

Prevalence: How common the health condition is within a specific population.
Affects 10-30% of patients with cirrhosis and ascites.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Advanced liver cirrhosis, low protein concentration in ascitic fluid, gastrointestinal bleeding, prior episodes of SBP.

Prognosis: The expected outcome or course of the condition over time.
With prompt treatment, the mortality rate can be reduced, but the recurrence rate is high without prophylaxis.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Sepsis, hepatic encephalopathy, acute kidney injury, death.

Typhoid Fever

Specialty: Infectious Diseases

Category: Bacterial Infections

Sub-category: Enteric Infections

Symptoms:
high fever; abdominal pain; diarrhea or constipation; headache; rash (rose spots); fatigue

Root Cause:
Caused by Salmonella enterica serotype Typhi, transmitted via contaminated food or water; bacteria invade intestinal lining and bloodstream.

How it's Diagnosed: videos
Blood, stool, or urine cultures; Widal test; PCR testing.

Treatment:
Antibiotics like ceftriaxone, azithromycin, or ciprofloxacin; hydration therapy.

Medications:
Ceftriaxone (third-generation cephalosporin, bactericidal); azithromycin (macrolide antibiotic); ciprofloxacin (fluoroquinolone class).

Prevalence: How common the health condition is within a specific population.
Endemic in regions with poor sanitation, especially South Asia, with millions of cases annually.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Ingesting contaminated food or water, poor sanitation, traveling to endemic areas.

Prognosis: The expected outcome or course of the condition over time.
Good with prompt antibiotic treatment; untreated cases have high mortality rates.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Intestinal perforation, sepsis, or chronic carrier state.

Clostridioides (Clostridium) Difficile Colitis

Specialty: Infectious Diseases

Category: Gastrointestinal Tract and Intra-abdominal Infections

Symptoms:
watery diarrhea; abdominal pain; fever; nausea; loss of appetite; dehydration; foul-smelling stool

Root Cause:
Infection caused by Clostridioides difficile bacteria, leading to an overgrowth in the colon often triggered by antibiotic use that disrupts normal gut flora.

How it's Diagnosed: videos
Stool tests for C. difficile toxins or genetic material (PCR), colonoscopy to identify pseudomembranous colitis, and imaging (e.g., CT scan) in severe cases.

Treatment:
Discontinuation of the inciting antibiotic, initiation of specific antibiotics to target C. difficile, and, in severe cases, fecal microbiota transplantation (FMT).

Medications:
Vancomycin (oral, first-line treatment for severe cases, classified as glycopeptide antibiotics), Fidaxomicin (narrow-spectrum antibiotic targeting C. difficile), and Metronidazole (alternative treatment for mild to moderate cases, classified as a nitroimidazole antibiotic).

Prevalence: How common the health condition is within a specific population.
Affects about 500,000 people annually in the U.S.; more common in hospitalized or recently discharged patients.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Recent antibiotic use, advanced age, hospitalization, weakened immune system, gastrointestinal surgery, proton pump inhibitor use.

Prognosis: The expected outcome or course of the condition over time.
Good with appropriate treatment; however, recurrence occurs in approximately 20–25% of patients.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Severe dehydration, toxic megacolon, bowel perforation, sepsis, and death in extreme cases.

Hepatitis A

Specialty: Infectious Diseases

Category: Liver Infections

Sub-category: Acute Viral Hepatitis

Symptoms:
fatigue; nausea; vomiting; abdominal pain; jaundice; dark urine; pale stools; fever

Root Cause:
Infection with the Hepatitis A virus (HAV) causing inflammation of the liver; spread primarily through contaminated food and water.

How it's Diagnosed: videos
Blood tests detecting HAV-specific IgM antibodies, liver function tests.

Treatment:
Primarily supportive care (rest, hydration, avoiding alcohol); no specific antiviral therapy.

Medications:
No antiviral medications; symptomatic relief with antipyretics (e.g., acetaminophen for fever) or antiemetics for nausea.

Prevalence: How common the health condition is within a specific population.
Common in areas with poor sanitation; estimated 1.4 million cases worldwide annually.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Travel to endemic regions, consuming contaminated food or water, close contact with an infected person.

Prognosis: The expected outcome or course of the condition over time.
Full recovery in most cases within weeks to months; no chronic infection.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Rare, but can include fulminant hepatitis in older adults or those with pre-existing liver conditions.

Hepatitis B

Specialty: Infectious Diseases

Category: Liver Infections

Sub-category: Chronic Viral Hepatitis

Symptoms:
fatigue; loss of appetite; nausea; jaundice; dark urine; joint pain; abdominal pain

Root Cause:
Infection with the Hepatitis B virus (HBV), which can cause both acute and chronic liver inflammation, leading to liver damage.

How it's Diagnosed: videos
Blood tests for HBsAg (surface antigen), anti-HBc antibodies, and HBV DNA; liver function tests.

Treatment:
Treated with antiviral medications such as tenofovir or entecavir to suppress viral replication, alongside interferon therapy in select cases, and supportive care, with monitoring for liver function and complications.

Medications:
Nucleos(t)ide analogs (e.g., entecavir , tenofovir ) to inhibit viral replication. Interferon-alpha injections to boost the immune response.

Prevalence: How common the health condition is within a specific population.
Affects over 296 million people worldwide; common in Asia and Africa.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Unprotected sex, needle-sharing, perinatal transmission, healthcare worker exposure.

Prognosis: The expected outcome or course of the condition over time.
Acute cases often resolve; chronic cases may progress to cirrhosis or liver cancer without treatment.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Liver cirrhosis, hepatocellular carcinoma, liver failure.

Hepatitis C

Specialty: Infectious Diseases

Category: Liver Infections

Sub-category: Chronic Viral Hepatitis

Symptoms:
fatigue; nausea; loss of appetite; jaundice; dark urine; joint pain; abdominal pain

Root Cause:
Infection with the Hepatitis C virus (HCV), often leading to chronic liver inflammation and scarring.

How it's Diagnosed: videos
Blood tests for anti-HCV antibodies and HCV RNA, liver function tests.

Treatment:
Direct-acting antivirals (DAAs) to cure the infection.

Medications:
DAAs (e.g., sofosbuvir , ledipasvir , velpatasvir ) targeting viral proteins for replication. Ribavirin (in combination in certain cases).

Prevalence: How common the health condition is within a specific population.
Affects over 58 million people worldwide; common in intravenous drug users.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Needle-sharing, blood transfusions (before 1992), healthcare exposure, tattoos or piercings with unsterilized equipment.

Prognosis: The expected outcome or course of the condition over time.
Highly curable with DAAs in 8–12 weeks; untreated, it may progress to cirrhosis or liver cancer.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Liver cirrhosis, hepatocellular carcinoma, portal hypertension.

Hepatitis D

Specialty: Infectious Diseases

Category: Liver Infections

Sub-category: Chronic Viral Hepatitis

Symptoms:
fatigue; nausea; jaundice; dark urine; abdominal pain; joint pain

Root Cause:
Co-infection or superinfection with the Hepatitis D virus (HDV) in individuals already infected with Hepatitis B. HDV requires HBV to replicate.

How it's Diagnosed: videos
Blood tests for anti-HDV antibodies and HDV RNA, liver function tests.

Treatment:
Pegylated interferon-alpha; no specific antiviral therapy.

Medications:
Pegylated interferon-alpha to suppress viral replication; supportive care.

Prevalence: How common the health condition is within a specific population.
Estimated 5–10% of individuals with HBV are co-infected with HDV.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Same as Hepatitis B, especially intravenous drug use and unprotected sex.

Prognosis: The expected outcome or course of the condition over time.
Worse than HBV alone; higher risk of progression to cirrhosis and liver cancer.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Liver cirrhosis, hepatocellular carcinoma, liver failure.

Hepatitis E

Specialty: Infectious Diseases

Category: Liver Infections

Sub-category: Acute Viral Hepatitis

Symptoms:
fatigue; nausea; jaundice; dark urine; pale stools; abdominal pain; fever

Root Cause:
Infection with the Hepatitis E virus (HEV), often spread through contaminated water, leading to acute liver inflammation.

How it's Diagnosed: videos
Blood tests for anti-HEV antibodies (IgM), HEV RNA in serum or stool.

Treatment:
Supportive care; ribavirin in severe or chronic cases (e.g., immunocompromised patients).

Medications:
Ribavirin (antiviral, used selectively for chronic cases).

Prevalence: How common the health condition is within a specific population.
Affects over 20 million people annually, primarily in developing regions.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Contaminated water, poor sanitation, undercooked pork or wild game meat.

Prognosis: The expected outcome or course of the condition over time.
Full recovery in most cases; higher mortality in pregnant women.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Acute liver failure, particularly in pregnant women or immunocompromised individuals.

Strongyloidiasis

Specialty: Infectious Diseases

Category: Gastrointestinal Tract and Intra-abdominal Infections

Sub-category: Parasitic Infections

Symptoms:
abdominal pain; diarrhea; weight loss; itchy skin rash; cough or wheezing in disseminated cases

Root Cause:
Chronic intestinal infection caused by the parasitic nematode Strongyloides stercoralis, with potential for autoinfection and systemic dissemination.

How it's Diagnosed: videos
Stool examination, serological tests (antibody detection), or PCR. Larvae may also be identified in duodenal aspirates or sputum in disseminated cases.

Treatment:
Anti-parasitic therapy with ivermectin or albendazole.

Medications:
Ivermectin (first-line) or albendazole (alternative). Both are anti-helminthic drugs.

Prevalence: How common the health condition is within a specific population.
Common in tropical and subtropical regions; less frequent in temperate areas.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Poor sanitation, immunosuppression, corticosteroid use, and travel to endemic regions.

Prognosis: The expected outcome or course of the condition over time.
Excellent with timely treatment; life-threatening in disseminated strongyloidiasis.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Hyperinfection syndrome, sepsis, and respiratory distress in severe cases.

Yellow Fever

Specialty: Infectious Diseases

Category: Gastrointestinal Tract and Intra-abdominal Infections

Symptoms:
fever; headache; muscle pain; nausea; vomiting; jaundice; abdominal pain; bleeding (e.g., from the gums or nose); organ failure in severe cases

Root Cause:
Yellow fever is caused by the yellow fever virus, a flavivirus transmitted by infected mosquitoes (primarily Aedes aegypti). It leads to systemic infection, liver damage, and subsequent jaundice and bleeding tendencies in severe cases.

How it's Diagnosed: videos
Diagnosed through serologic tests or PCR.

Treatment:
Treated supportively, as no specific antiviral therapy exists, with vaccination as a key preventive measure.

Medications:
No antiviral medications are available for yellow fever. Supportive medications include antipyretics like acetaminophen (avoid NSAIDs like ibuprofen or aspirin to reduce bleeding risks) and intravenous fluids for dehydration. Hemostatic agents may be used in cases of severe bleeding.

Prevalence: How common the health condition is within a specific population.
Yellow fever is endemic in tropical areas of Africa and South America. Annually, it causes an estimated 200,000 cases and 30,000 deaths globally, with most cases unreported.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Traveling to or living in endemic areas, lack of vaccination, and exposure to mosquito bites.

Prognosis: The expected outcome or course of the condition over time.
In mild cases, recovery occurs within days to weeks without long-term effects. Severe cases with complications like liver failure or bleeding have a mortality rate of 20–50%. Survivors of severe cases typically recover fully but may require prolonged convalescence.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Hepatic failure, renal failure, shock, disseminated intravascular coagulation (DIC), multi-organ failure, and death in severe cases.

Middle East Respiratory Syndrome (MERS)

Specialty: Infectious Diseases

Category: Lower Respiratory Tract Infections

Symptoms:
fever; cough; shortness of breath; muscle pain; nausea; vomiting; diarrhea; abdominal pain

Root Cause:
Caused by the MERS-CoV coronavirus, transmitted through respiratory droplets or contact with infected individuals or camels. Severe cases involve acute respiratory distress syndrome (ARDS).

How it's Diagnosed: videos
Diagnosis is based on PCR testing for MERS-CoV in respiratory samples, chest imaging to detect pneumonia or ARDS, and serologic tests.

Treatment:
Supportive care, including oxygen therapy, mechanical ventilation in severe cases, and treatment of secondary infections. No specific antiviral therapy is widely accepted.

Medications:
Experimental - Antivirals (e.g., ribavirin ) combined with interferon have been investigated but are not standard treatments. Supportive medications - Antipyretics for fever, and bronchodilators for respiratory relief.

Prevalence: How common the health condition is within a specific population.
Outbreaks have primarily occurred in the Middle East. Limited cases in other regions due to travel-associated spread. Mortality rates range from 30-40%.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Close contact with camels, healthcare exposure to infected individuals, age over 50, pre-existing chronic diseases (e.g., diabetes, heart disease).

Prognosis: The expected outcome or course of the condition over time.
Severe cases can progress to multi-organ failure and death, particularly in high-risk groups. Mild cases may resolve with symptomatic management.

Complications: Additional problems or conditions that may arise as a result of the original condition.
ARDS, septic shock, renal failure, and long-term pulmonary complications in survivors.

Alveolar Echinococcosis (AE)

Specialty: Infectious Diseases

Category: Parasitic Infections

Symptoms:
abdominal pain; weight loss; jaundice; liver enlargement; nausea; weakness

Root Cause:
Caused by the larval stage of Echinococcus multilocularis, which forms invasive cysts, primarily in the liver.

How it's Diagnosed: videos
Imaging studies (ultrasound, CT, MRI), serological testing for Echinococcus antibodies, and biopsy for definitive diagnosis.

Treatment:
Surgical removal of the lesion when possible, long-term antiparasitic therapy.

Medications:
Albendazole (anthelmintic) is the primary medication; mebendazole is an alternative.

Prevalence: How common the health condition is within a specific population.
Rare, primarily found in the northern hemisphere, including parts of Europe, Asia, and North America.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Contact with infected animals (e.g., dogs, foxes), consuming contaminated food or water, and living in endemic regions.

Prognosis: The expected outcome or course of the condition over time.
Good with early detection and treatment; untreated cases have a poor prognosis due to invasive growth.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Liver failure, metastasis to other organs, secondary infections.

Amebiasis

Specialty: Infectious Diseases

Category: Parasitic Infections

Symptoms:
diarrhea; abdominal pain; cramping; bloody stools; fever; weight loss

Root Cause:
Infection with Entamoeba histolytica through ingestion of contaminated food or water, causing intestinal and, in some cases, extraintestinal infections such as liver abscesses.

How it's Diagnosed: videos
Stool examination for trophozoites or cysts, antigen detection tests, serological assays, imaging (ultrasound or CT) for liver abscesses.

Treatment:
Antiparasitic medications, drainage of liver abscesses if necessary.

Medications:
Metronidazole or tinidazole (antiprotozoal drugs) are used for tissue-invasive disease, followed by luminal agents like paromomycin or iodoquinol to eliminate cysts in the intestine.

Prevalence: How common the health condition is within a specific population.
Common in tropical and subtropical regions, particularly in areas with poor sanitation.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Poor hygiene, contaminated water supply, close contact with infected individuals.

Prognosis: The expected outcome or course of the condition over time.
Excellent with prompt treatment; severe cases can lead to complications if untreated.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Liver abscesses, perforation of the colon, peritonitis, and dissemination to other organs.

Ascariasis

Specialty: Infectious Diseases

Category: Parasitic Infections

Symptoms:
abdominal pain; nausea; vomiting; malnutrition; intestinal blockage; cough (during larval migration)

Root Cause:
Infection with Ascaris lumbricoides, a roundworm transmitted through ingestion of eggs from contaminated soil or food.

How it's Diagnosed: videos
Stool analysis for eggs, imaging studies for intestinal obstruction, and sometimes ultrasound or CT for heavy infections.

Treatment:
Anthelmintic medications, sometimes surgery for complications.

Medications:
Albendazole or mebendazole are commonly prescribed; pyrantel pamoate is an alternative.

Prevalence: How common the health condition is within a specific population.
Highly prevalent in tropical and subtropical regions, especially in areas with poor sanitation.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Contaminated soil or water, poor hygiene, and living in endemic areas.

Prognosis: The expected outcome or course of the condition over time.
Excellent with treatment; severe cases with complications may require additional interventions.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Intestinal obstruction, malnutrition, growth retardation in children, and migration of worms to other organs.

Balantidiasis

Specialty: Infectious Diseases

Category: Parasitic Infections

Symptoms:
diarrhea; abdominal pain; nausea; vomiting; fever; weight loss

Root Cause:
Infection with Balantidium coli, a ciliate protozoan, typically acquired from contaminated food or water.

How it's Diagnosed: videos
Stool examination for trophozoites or cysts; rarely, colonoscopy and biopsy.

Treatment:
Antiprotozoal therapy.

Medications:
Tetracycline is the first-line treatment; metronidazole or iodoquinol are alternatives.

Prevalence: How common the health condition is within a specific population.
Rare, typically found in areas with poor sanitation and exposure to swine.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Close contact with pigs, contaminated water, and poor hygiene.

Prognosis: The expected outcome or course of the condition over time.
Good with treatment; untreated severe cases may lead to complications.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Perforation of the colon, peritonitis.

Cryptosporidiosis

Specialty: Infectious Diseases

Category: Parasitic Infections

Symptoms:
watery diarrhea; abdominal pain; nausea; vomiting; fever; weight loss; dehydration

Root Cause:
Infection with Cryptosporidium species, primarily transmitted through ingestion of contaminated water or food.

How it's Diagnosed: videos
Stool analysis using acid-fast staining, direct fluorescent antibody tests, or PCR for Cryptosporidium DNA.

Treatment:
Supportive care to prevent dehydration; specific antiparasitic therapy for immunocompromised individuals.

Medications:
Nitazoxanide (antiprotozoal) is the primary treatment. Antidiarrheal agents may be used for symptom control.

Prevalence: How common the health condition is within a specific population.
Common worldwide, especially in children and immunocompromised individuals in low-resource settings.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Contaminated water sources, poor sanitation, immunosuppression (e.g., HIV/AIDS).

Prognosis: The expected outcome or course of the condition over time.
Good for immunocompetent individuals; chronic or severe disease in immunosuppressed patients.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Severe dehydration, malnutrition, and chronic diarrhea in immunocompromised individuals.

Cystoisosporiasis

Specialty: Infectious Diseases

Category: Parasitic Infections

Symptoms:
watery diarrhea; abdominal pain; cramping; nausea; vomiting; weight loss; fever

Root Cause:
Infection with Cystoisospora belli (formerly known as Isospora belli), a parasitic protozoan that invades the epithelial cells of the small intestine.

How it's Diagnosed: videos
Microscopic examination of stool samples to detect oocysts; acid-fast staining or molecular tests (e.g., PCR) may be used.

Treatment:
Primarily with antiparasitic medication and supportive care (rehydration and nutritional support).

Medications:
Trimethoprim-sulfamethoxazole (antibiotic combination, also known as Bactrim ) is the first-line treatment. For sulfa-allergic patients, pyrimethamine with leucovorin (folic acid) may be used.

Prevalence: How common the health condition is within a specific population.
Rare in developed countries; more common in tropical and subtropical regions and in immunocompromised individuals (e.g., HIV/AIDS).

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Immunosuppression, travel to or residence in endemic areas, poor sanitation, consumption of contaminated food or water.

Prognosis: The expected outcome or course of the condition over time.
Good with prompt treatment; chronic or recurrent infections may occur in immunocompromised patients.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Chronic diarrhea, malabsorption, dehydration, and significant weight loss, especially in immunocompromised individuals.

Dipylidiasis

Specialty: Infectious Diseases

Category: Parasitic Infections

Symptoms:
mild gastrointestinal discomfort; diarrhea; abdominal pain; anal pruritus; irritability in children

Root Cause:
Infection with Dipylidium caninum, a tapeworm transmitted through ingestion of infected fleas or flea larvae.

How it's Diagnosed: videos
Detection of proglottids in stool or around the perianal area; microscopic identification of egg packets in stool samples.

Treatment:
Anthelmintic medications combined with flea control measures to prevent reinfection.

Medications:
Praziquantel (anthelmintic) is the treatment of choice.

Prevalence: How common the health condition is within a specific population.
Sporadic cases globally; commonly associated with children and pet owners due to close contact with dogs and cats.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Exposure to infected pets or fleas, lack of flea control, and poor hygiene practices.

Prognosis: The expected outcome or course of the condition over time.
Excellent with treatment; minimal risk of complications.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Rare; potential reinfection if flea control is inadequate.

Echinococcosis (Hydatid Cyst)

Specialty: Infectious Diseases

Category: Parasitic Infections

Symptoms:
abdominal pain; nausea; vomiting; cyst-related pressure effects; allergic reactions if the cyst ruptures

Root Cause:
Infection with Echinococcus granulosus or Echinococcus multilocularis, causing cystic or alveolar echinococcosis, respectively.

How it's Diagnosed: videos
Imaging studies (ultrasound, CT, or MRI), serological tests (ELISA, Western blot), and histopathological examination.

Treatment:
Surgical removal of cysts, percutaneous aspiration (PAIR technique), or antiparasitic drug therapy for inoperable cases.

Medications:
Albendazole and mebendazole (anthelmintics) are used to reduce cyst size or as adjuncts to surgery.

Prevalence: How common the health condition is within a specific population.
Endemic in sheep-raising regions such as the Middle East, Central Asia, South America, and parts of Africa.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Contact with infected dogs, livestock farming, poor hygiene practices.

Prognosis: The expected outcome or course of the condition over time.
Variable; excellent with early intervention, but alveolar echinococcosis can be life-threatening if untreated.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Cyst rupture leading to anaphylaxis, secondary bacterial infections, or dissemination of the infection.

Hookworm Disease

Specialty: Infectious Diseases

Category: Parasitic Infections

Symptoms:
iron deficiency anemia; fatigue; abdominal pain; diarrhea; nausea; itching and rash at the site of skin penetration (ground itch)

Root Cause:
Infection with hookworms such as Ancylostoma duodenale or Necator americanus, which attach to the intestinal lining and feed on blood.

How it's Diagnosed: videos
Stool examination for eggs or larvae; molecular methods may confirm the species.

Treatment:
Anthelmintic medications and iron supplementation for anemia.

Medications:
Albendazole or mebendazole (anthelmintics) are the drugs of choice. Pyrantel pamoate can be used as an alternative.

Prevalence: How common the health condition is within a specific population.
Common in tropical and subtropical regions with poor sanitation.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Walking barefoot on contaminated soil, poor sanitation, and inadequate access to clean water.

Prognosis: The expected outcome or course of the condition over time.
Good with treatment; untreated infections may lead to severe anemia and developmental delays in children.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Chronic anemia, malnutrition, and growth retardation in children.

Intestinal Flukes

Specialty: Infectious Diseases

Category: Parasitic Infections

Symptoms:
abdominal pain; diarrhea; nausea; malabsorption; weakness

Root Cause:
Infection with trematodes such as Fasciolopsis buski, acquired through ingestion of raw or undercooked aquatic plants contaminated with metacercariae.

How it's Diagnosed: videos
Stool examination for eggs; imaging or serological tests may assist in diagnosis.

Treatment:
Anthelmintic medications and supportive care for symptoms.

Medications:
Praziquantel (anthelmintic) is the treatment of choice. Nitazoxanide may be considered in some cases.

Prevalence: How common the health condition is within a specific population.
Common in parts of Southeast Asia and India where aquatic plants are consumed.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Consumption of contaminated water plants (e.g., water chestnuts), poor sanitation, and exposure to infected water sources.

Prognosis: The expected outcome or course of the condition over time.
Good with appropriate treatment; complications are rare.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Chronic malabsorption and malnutrition if untreated.

Microsporidiosis

Specialty: Infectious Diseases

Category: Parasitic Infections

Symptoms:
chronic diarrhea; abdominal pain; weight loss; nausea; vomiting; fever; ocular inflammation (in cases of eye involvement)

Root Cause:
Caused by microsporidia, intracellular parasites primarily affecting immunocompromised individuals.

How it's Diagnosed: videos
Microscopy (modified trichrome stain), PCR, and electron microscopy.

Treatment:
Antiparasitic medications, rehydration therapy, and managing underlying immunosuppression.

Medications:
Albendazole (a broad-spectrum antiparasitic) for systemic infections; fumagillin or topical agents for ocular infections.

Prevalence: How common the health condition is within a specific population.
Found worldwide, particularly in HIV/AIDS patients and organ transplant recipients.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Immunosuppression (e.g., HIV/AIDS, chemotherapy), exposure to contaminated water or food.

Prognosis: The expected outcome or course of the condition over time.
Treatable, but complications are more severe in immunocompromised individuals.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Chronic malabsorption, systemic spread, and severe organ-specific infections.

Nematode Infections

Specialty: Infectious Diseases

Category: Parasitic Infections

Symptoms:
abdominal pain; diarrhea; malnutrition; anemia; skin rashes; itching; respiratory symptoms in some cases

Root Cause:
Caused by roundworms such as Ascaris lumbricoides, Ancylostoma duodenale (hookworms), and Strongyloides stercoralis.

How it's Diagnosed: videos
Stool examination for eggs or larvae, blood tests for eosinophilia, and PCR for species identification.

Treatment:
Antiparasitic medications and supportive care for malnutrition or anemia.

Medications:
Albendazole or mebendazole (broad-spectrum anti-helminthics), ivermectin (for strongyloidiasis), pyrantel pamoate (for specific nematodes).

Prevalence: How common the health condition is within a specific population.
Affects over 1.5 billion people worldwide, especially in tropical and subtropical regions.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Poor sanitation, contaminated water, lack of hygiene, barefoot walking in endemic areas.

Prognosis: The expected outcome or course of the condition over time.
Treatable, but chronic infections can cause growth retardation and severe complications in children.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Intestinal obstruction, nutritional deficiencies, and systemic infection (e.g., disseminated strongyloidiasis).

Pinworm (Enterobiasis)

Specialty: Infectious Diseases

Category: Parasitic Infections

Symptoms:
perianal itching; restlessness; irritability; abdominal pain; loss of appetite

Root Cause:
Caused by Enterobius vermicularis, a small intestinal nematode transmitted through ingestion of eggs.

How it's Diagnosed: videos
Visualization of worms or eggs on the perianal area using the "tape test."

Treatment:
Antiparasitic medications and hygiene measures to prevent reinfection.

Medications:
Mebendazole or albendazole (broad-spectrum anti-helminthics), pyrantel pamoate .

Prevalence: How common the health condition is within a specific population.
Common worldwide, especially among children in crowded settings.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Poor hygiene, close contact with infected individuals.

Prognosis: The expected outcome or course of the condition over time.
Easily treatable with medications and proper hygiene.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Rarely, chronic infections can cause appendicitis or other gastrointestinal issues.

Schistosomiasis (Bilharzia)

Specialty: Infectious Diseases

Category: Parasitic Infections

Symptoms:
rash or itchy skin; fever; chills; cough; abdominal pain; diarrhea; blood in urine or stool; fatigue

Root Cause:
Caused by infection with Schistosoma parasites, transmitted through contact with freshwater containing the larval form of the parasite.

How it's Diagnosed: videos
Stool or urine examination for eggs, serological tests, and imaging for organ involvement.

Treatment:
Antiparasitic medication is the main treatment, along with supportive care for complications.

Medications:
Praziquantel is the drug of choice, classified as an antiparasitic.

Prevalence: How common the health condition is within a specific population.
Affects over 200 million people worldwide, particularly in sub-Saharan Africa.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Exposure to freshwater in endemic areas, lack of clean water access, poor sanitation.

Prognosis: The expected outcome or course of the condition over time.
Good with early treatment; chronic cases may lead to long-term organ damage.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Liver fibrosis, bladder cancer, infertility, and increased risk of portal hypertension.

Tapeworm Infestation

Specialty: Infectious Diseases

Category: Parasitic Infections

Symptoms:
abdominal pain; nausea; diarrhea; weight loss; visible segments in stool

Root Cause:
Caused by ingestion of Taenia or other tapeworm species through undercooked meat or contaminated water.

How it's Diagnosed: videos
Stool sample analysis, serological tests for antibodies, and imaging for cysts.

Treatment:
Antiparasitic medication with symptomatic relief for gastrointestinal discomfort.

Medications:
Praziquantel and albendazole , classified as antiparasitics.

Prevalence: How common the health condition is within a specific population.
Common in regions with poor food safety and hygiene; global cases vary by tapeworm species.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Eating undercooked or raw meat, poor hygiene, and exposure to contaminated water or food.

Prognosis: The expected outcome or course of the condition over time.
Good with treatment, but untreated cases may lead to severe complications.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Intestinal blockage, cysticercosis, and neurocysticercosis (when cysts develop in the brain).

Toxocariasis

Specialty: Infectious Diseases

Category: Parasitic Infections

Symptoms:
fever; cough; abdominal pain; wheezing; blurred vision

Root Cause:
Caused by larvae of Toxocara species, transmitted via ingestion of soil contaminated with animal feces.

How it's Diagnosed: videos
Blood tests for antibodies, imaging for organ involvement, and clinical symptoms.

Treatment:
Antiparasitic drugs and corticosteroids for severe inflammation.

Medications:
Albendazole or mebendazole , both classified as antiparasitics.

Prevalence: How common the health condition is within a specific population.
Found worldwide; higher prevalence in areas with poor sanitation.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Contact with contaminated soil, owning pets not dewormed regularly.

Prognosis: The expected outcome or course of the condition over time.
Good with treatment; severe cases may result in long-term organ damage.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Ocular toxocariasis leading to vision loss, and visceral involvement causing organ damage.

Trematode Infection

Specialty: Infectious Diseases

Category: Parasitic Infections

Symptoms:
fever; abdominal pain; diarrhea; weight loss; jaundice (in liver fluke infections); cough and chest pain (in lung fluke infections)

Root Cause:
Trematode infections are caused by parasitic flatworms (flukes) that invade the gastrointestinal tract, liver, lungs, or blood, depending on the species.

How it's Diagnosed: videos
Stool or urine examination to detect eggs, serologic tests, imaging (e.g., ultrasound, CT, or MRI) for organ involvement, and biopsy in some cases.

Treatment:
Antiparasitic medication, supportive care for symptoms, and in severe cases, surgical intervention for organ damage.

Medications:
Praziquantel , an antiparasitic medication that disrupts the parasite's membrane , is the primary treatment.

Prevalence: How common the health condition is within a specific population.
Endemic in tropical and subtropical regions; common in areas with poor sanitation and close contact with freshwater sources.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Consumption of raw or undercooked freshwater fish, crabs, or plants; exposure to contaminated water; poor sanitation.

Prognosis: The expected outcome or course of the condition over time.
Generally good with early diagnosis and treatment, but untreated cases can lead to severe organ damage and complications.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Liver fibrosis, portal hypertension, cholangiocarcinoma, pulmonary complications, and secondary bacterial infections.

Bacterial Infections and Pregnancy

Specialty: Infectious Diseases

Category: Special Topics

Symptoms:
fever; abdominal pain; vaginal discharge; preterm labor; maternal sepsis; fetal distress

Root Cause:
Bacterial infections in pregnancy can result from common pathogens like Group B Streptococcus, Listeria, E. coli, or Chlamydia, affecting maternal and fetal health.

How it's Diagnosed: videos
Diagnosis involves clinical evaluation, culture tests (blood, urine, vaginal swabs), imaging (if necessary), and specific tests for pathogens (PCR or antigen-based tests).

Treatment:
Treatment includes targeted antibiotic therapy, managing maternal symptoms, and monitoring fetal health. Hospitalization may be required for severe cases.

Medications:
Antibiotics such as amoxicillin , azithromycin , ceftriaxone , or penicillin are commonly prescribed. These belong to beta-lactam antibiotics, macrolides, or cephalosporins, ensuring safety for the mother and fetus.

Prevalence: How common the health condition is within a specific population.
Approximately 10-30% of pregnant women may be carriers of Group B Streptococcus; other infections like Listeria are less common but significant due to potential complications.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
History of preterm delivery, poor hygiene, lack of prenatal care, unpasteurized food consumption, and untreated infections.

Prognosis: The expected outcome or course of the condition over time.
With early diagnosis and appropriate treatment, outcomes for mother and baby are generally favorable. Untreated infections can lead to severe complications, including sepsis or neonatal mortality.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Preterm labor, miscarriage, neonatal sepsis, maternal sepsis, or long-term developmental issues in the infant.

Ebola Virus Infection

Specialty: Infectious Diseases

Category: Viral Hemorrhagic Fevers

Sub-category: Filoviruses

Symptoms:
fever; severe headache; muscle pain; fatigue; diarrhea; vomiting; abdominal pain; unexplained bleeding or bruising

Root Cause:
Systemic infection caused by the Ebola virus, leading to vascular damage, coagulopathy, and immune system dysregulation.

How it's Diagnosed: videos
PCR testing for Ebola RNA, enzyme-linked immunosorbent assay (ELISA), antigen detection tests, and clinical signs in endemic areas.

Treatment:
Supportive care including fluids, electrolyte management, oxygen therapy, and blood products; antivirals like Inmazeb (monoclonal antibody combination) may be used.

Medications:
Inmazeb (monoclonal antibody therapy), mAb114 (monoclonal antibody), and experimental antiviral drugs under trial during outbreaks.

Prevalence: How common the health condition is within a specific population.
Outbreaks primarily in sub-Saharan Africa; rare outside endemic areas.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Contact with infected individuals, handling contaminated body fluids, exposure to bats or other reservoir species, and poor infection control practices.

Prognosis: The expected outcome or course of the condition over time.
Mortality rates range from 25% to 90%, depending on the strain and access to medical care. Survivors often experience long-term complications.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Multiorgan failure, shock, disseminated intravascular coagulation (DIC), and long-term sequelae such as joint pain and vision problems.