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Sub-Category:

Vaccine Adjuvant Allergy

Sub-category: Vaccine-related Allergies

Symptoms:
redness and swelling at the injection site; urticaria; angioedema; anaphylaxis (rare); systemic symptoms (e.g., fever, malaise)

Root Cause:
Hypersensitivity to vaccine adjuvants (e.g., aluminum salts, polyethylene glycol), which are used to enhance the immune response.

How it's Diagnosed: videos
Diagnosed via clinical history and allergy testing (e.g., skin tests or blood tests for adjuvants).

Treatment:
Treated with desensitization protocols, alternative vaccines, or premedication strategies.

Medications:
Antihistamines (e.g., Cetirizine ) and corticosteroids (e.g., Prednisone ) for mild reactions, with avoidance strategies for severe cases.

Prevalence: How common the health condition is within a specific population.
Rare; exact rates are unknown.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
History of allergic reactions to medications or cosmetics; Multiple allergies; Previous vaccine reactions

Prognosis: The expected outcome or course of the condition over time.
Manageable with alternative vaccination strategies; reactions can often be prevented or minimized.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Missed vaccinations; Anaphylaxis (if undiagnosed); Reduced immunity to preventable diseases

PEG (Polyethylene Glycol) or Polysorbate Allergy

Specialty: Allergies and Immunology

Category: Other Related Disorders

Sub-category: Vaccine-related Allergies

Symptoms:
urticaria; angioedema; anaphylaxis; respiratory distress

Root Cause:
Hypersensitivity reaction to PEG or polysorbates, commonly used as excipients in medications, cosmetics, and vaccines.

How it's Diagnosed: videos
Skin testing, oral or intramuscular challenge under medical supervision, and review of reaction history.

Treatment:
Avoidance of PEG or polysorbate-containing products, use of alternative formulations, and epinephrine for anaphylactic reactions.

Medications:
Epinephrine for severe reactions and careful evaluation before re-exposure or alternative formulations.

Prevalence: How common the health condition is within a specific population.
Extremely rare; true prevalence is unknown but increasing awareness due to vaccine reactions.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Prior exposure to PEG or polysorbates, history of drug allergies, and atopic conditions.

Prognosis: The expected outcome or course of the condition over time.
Good with avoidance strategies and alternative therapies.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Severe allergic reactions with accidental exposure.