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Sub-Category:

Vasculitis-Associated Glomerulonephritis

Number of Conditions: 1

Cryoglobulinemic Glomerulonephritis

Specialty: Nephrology

Category: Glomerular Diseases

Sub-category: Vasculitis-Associated Glomerulonephritis

Symptoms:
blood in the urine; foamy urine; swelling in legs and feet; fatigue; purpura (skin rash)

Root Cause:
Immune complex deposition in the kidneys caused by cryoglobulins, proteins that precipitate at low temperatures.

How it's Diagnosed: videos
Diagnosed with kidney biopsy and detection of cryoglobulins in blood.

Treatment:
Treated with antiviral therapy for hepatitis C, corticosteroids, plasmapheresis, and rituximab for severe cases.

Medications:
Antiviral therapy for hepatitis C (e.g., direct-acting antivirals), corticosteroids, and rituximab .

Prevalence: How common the health condition is within a specific population.
Rare; often associated with chronic hepatitis C.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Chronic hepatitis C infection, autoimmune diseases, and lymphoproliferative disorders.

Prognosis: The expected outcome or course of the condition over time.
Variable; treatment of underlying causes improves outcomes. Without treatment, may lead to chronic kidney disease or end-stage renal disease.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Chronic kidney disease, kidney failure, and systemic vasculitis affecting other organs.