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Sub-Category:

Non-Alcoholic Fatty Liver Disease (NAFLD)

Number of Conditions: 1

Non-Alcoholic Steatohepatitis (NASH)

Specialty: Gastrointestinal

Category: Liver Disorders

Sub-category: Non-Alcoholic Fatty Liver Disease (NAFLD)

Symptoms:
fatigue; mild abdominal discomfort; enlarged liver (hepatomegaly); jaundice (in advanced cases); asymptomatic in early stages

Root Cause:
Fat accumulation in the liver causing inflammation and damage, not related to alcohol use.

How it's Diagnosed: videos
Liver function tests, imaging (ultrasound, CT, or MRI), and liver biopsy.

Treatment:
Lifestyle changes (weight loss, healthy diet, exercise), management of comorbidities (diabetes, dyslipidemia).

Medications:
Vitamin E (antioxidant for non-diabetic patients). Pioglitazone (insulin sensitizer, for patients with type 2 diabetes). Obeticholic acid (under study for reducing liver inflammation and fibrosis).

Prevalence: How common the health condition is within a specific population.
Affects about 3–5% of the global population; more common in individuals with obesity or diabetes.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Obesity, type 2 diabetes, metabolic syndrome, dyslipidemia, sedentary lifestyle.

Prognosis: The expected outcome or course of the condition over time.
Variable; can remain stable with lifestyle modifications or progress to cirrhosis and liver failure if untreated.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Cirrhosis, liver failure, hepatocellular carcinoma, cardiovascular disease.