Condition Lookup
Sub-Category:
Drug-Related Skin Reactions
Number of Conditions: 3
Stevens-Johnson Syndrome (SJS)
Specialty: Dermatology
Category: Other Dermatologic Conditions
Sub-category: Drug-Related Skin Reactions
Symptoms:
blisters and erosions on skin and mucous membranes; target-like lesions; fever and malaise
Root Cause:
Severe hypersensitivity reaction, often drug-induced, involving keratinocyte apoptosis.
How it's Diagnosed: videos
Clinical findings; biopsy to confirm.
Treatment:
Discontinuation of the offending drug; supportive care in severe cases.
Medications:
Corticosteroids or IVIG – for severe cases.
Prevalence:
How common the health condition is within a specific population.
Rare; 1–6 cases per million annually.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Certain medications, HIV infection, genetic predisposition (e.g., HLA-B*1502 in Asians).
Prognosis:
The expected outcome or course of the condition over time.
High morbidity; mortality ranges from 5–10%.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Sepsis; Organ failure; Scarring and chronic pain
Drug-Induced Rash
Specialty: Dermatology
Category: Other Dermatologic Conditions
Sub-category: Drug-Related Skin Reactions
Symptoms:
red, itchy rash; maculopapular or urticarial lesions; widespread distribution
Root Cause:
Hypersensitivity reaction to medications.
How it's Diagnosed: videos
Clinical history and elimination of suspected drug.
Treatment:
Discontinuation of the offending drug; antihistamines or corticosteroids for symptom relief.
Medications:
Antihistamines (e.g., diphenhydramine ). Systemic corticosteroids – for severe reactions.
Prevalence:
How common the health condition is within a specific population.
Common, especially with antibiotics or anticonvulsants.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Drug allergies, polypharmacy.
Prognosis:
The expected outcome or course of the condition over time.
Resolves upon drug discontinuation.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Progression to severe reactions (e.g., SJS/TEN)
Fixed Drug Eruption
Specialty: Dermatology
Category: Other Dermatologic Conditions
Sub-category: Drug-Related Skin Reactions
Symptoms:
recurrent, well-demarcated red patches; lesions often appear in the same location; may blister or darken over time
Root Cause:
Delayed hypersensitivity reaction to a drug.
How it's Diagnosed: videos
Clinical history; re-challenge with suspected drug if necessary.
Treatment:
Discontinuation of the offending drug; corticosteroids for active lesions.
Medications:
Topical corticosteroids (e.g., clobetasol ).
Prevalence:
How common the health condition is within a specific population.
Rare.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Previous reaction to a specific medication.
Prognosis:
The expected outcome or course of the condition over time.
Resolves after drug discontinuation; recurs with re-exposure.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Persistent pigmentation changes