Condition Lookup
Category:
Hematologic-Related Kidney Conditions
Number of Conditions: 1
Kidney Involvement in Multiple Myeloma (Myeloma Kidney)
Specialty: Nephrology
Category: Hematologic-Related Kidney Conditions
Symptoms:
fatigue; swelling in legs; decreased urine output; bone pain; frequent infections; nausea and vomiting
Root Cause:
Deposition of light chains in the kidney tubules due to excessive production by malignant plasma cells, leading to tubular obstruction and renal damage.
How it's Diagnosed: videos
Blood tests (serum protein electrophoresis, serum free light chains), urine tests (Bence-Jones protein), kidney biopsy, and imaging (X-rays, MRI, or PET scans for bone lesions).
Treatment:
Management of multiple myeloma with chemotherapy, stem cell transplantation, and supportive measures for kidney function, such as avoiding nephrotoxic drugs and adequate hydration.
Medications:
Medications include bortezomib (proteasome inhibitor), lenalidomide (immunomodulatory drug), and dexamethasone (corticosteroid). These are classified as targeted therapies and supportive treatments.
Prevalence:
How common the health condition is within a specific population.
Kidney involvement occurs in approximately 20-50% of multiple myeloma cases.
Risk Factors:
Factors or behaviors that increase the likelihood of developing the condition.
Multiple myeloma diagnosis, advanced age, male sex, African-American ethnicity.
Prognosis:
The expected outcome or course of the condition over time.
Prognosis depends on the stage of multiple myeloma and kidney function at the time of diagnosis; early intervention improves outcomes.
Complications:
Additional problems or conditions that may arise as a result of the original condition.
Chronic kidney disease, electrolyte imbalances, anemia, and an increased risk of infections.