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Category:

Disorders of Lymphocytic Function

Number of Conditions: 1

Pure B-Cell Disorders

Specialty: Hematology

Category: Disorders of Lymphocytic Function

Symptoms:
frequent bacterial infections; recurrent respiratory tract infections; poor response to vaccines; failure to thrive in infants

Root Cause:
Dysfunction or absence of B lymphocytes, leading to impaired production of antibodies.

How it's Diagnosed: videos
Blood tests for B-cell count, immunoglobulin levels, and specific antibody responses; genetic testing in some cases.

Treatment:
Immunoglobulin replacement therapy (intravenous or subcutaneous), prophylactic antibiotics, and bone marrow transplantation in severe cases.

Medications:
Immunoglobulin therapy (e.g., intravenous immunoglobulin [IVIG] or subcutaneous immunoglobulin [SCIG]), prophylactic antibiotics like trimethoprim-sulfamethoxazole (antibiotic), and antifungal agents if indicated.

Prevalence: How common the health condition is within a specific population.
Rare; exact prevalence depends on the specific type of B-cell disorder but can be as low as 1 in 100,000.

Risk Factors: Factors or behaviors that increase the likelihood of developing the condition.
Family history of immunodeficiencies, genetic mutations affecting B-cell development or function.

Prognosis: The expected outcome or course of the condition over time.
Variable; with treatment, many individuals can manage symptoms effectively, but severe cases may have life-threatening complications if untreated.

Complications: Additional problems or conditions that may arise as a result of the original condition.
Severe infections (e.g., pneumonia, meningitis), failure to thrive, and potential progression to life-threatening systemic infections.